MCID: ATM007
MIFTS: 38

Autoimmune Disease of Central Nervous System malady

Neuronal diseases category

Summaries for Autoimmune Disease of Central Nervous System

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 An autoimmune disease of the central nervous system.

MalaCards: Autoimmune Disease of Central Nervous System is related to malaria and dementia. An important gene associated with Autoimmune Disease of Central Nervous System is C3 (complement component 3), and among its related pathways are Leishmaniasis and B cell receptor signaling pathway. The compounds norepinephrine and indomethacin have been mentioned in the context of this disorder. Affiliated tissues include testes and t cells, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Aliases & Classifications for Autoimmune Disease of Central Nervous System

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8Disease Ontology
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autoimmune disease of central nervous system 8


External Ids:

Disease Ontology8 DOID:0060004

Related Diseases for Autoimmune Disease of Central Nervous System

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

autoimmune disease of central nervous system Autoimmune Disease of the Nervous System
Central Nervous System Disease Congenital Nervous System Abnormality

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1malaria10.0AMBP
2dementia10.0AMBP
3hypothyroidism10.0TTR
4age related macular degeneration10.0C3
5myocardial infarction10.0APOA1
6thromboembolism10.0APOA1
7coronary heart disease10.0APOA1
8guillain-barre syndrome10.0CD40LG
9polycystic ovary syndrome10.0APOA1
10arteriosclerosis10.0APOA1
11essential hypertension10.0APOA1
12inflammatory bowel disease10.0CD79A
13purpura10.0CD79A
14pemphigus10.0CD79A
15sinusitis10.0CD79A
16otitis media10.0CD79A
17rhinitis10.0CD79A
18thyroiditis10.0CD79A
19prostatitis10.0CD79A
20conjunctivitis10.0CD79A
21bronchitis10.0CD79A
22pertussis10.0CD79A
23lyme disease10.0CD40LG
24peripheral vascular disease10.0CD79A
25brucellosis10.0CD79A
26mumps10.0CD79A
27psoriasis10.0IL17A
28myelodysplastic syndromes10.0TF
29hyperthyroxinemia10.0TTR
30collagenous colitis10.0NOS2
31endometriosis10.0IL17A
32allergic rhinitis10.0IL17A
33celiac disease10.0CD79A
34bronchiectasis10.0CD79A
35myocarditis10.0NOS2
36diabetic retinopathy10.0NOS2
37influenza10.0CD79A
38cd40 ligand deficiency10.0CD40LG
39gastrointestinal system disease10.0NOS2
40alcohol abuse10.0TF
41synovitis10.0IL17A
42wilson disease10.0TF
43gingivitis10.0IL17A
44uveitis10.0IL17A
45protein-losing enteropathy10.0TF
46candidiasis10.0CD79A
47cryptosporidiosis10.0CD79A
48eosinophilia10.0CD79A
49hyperglycemia10.0NOS2
50hepatitis10.0TTR, CD40LG

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to autoimmune disease of central nervous system

Clinical Features for Autoimmune Disease of Central Nervous System

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Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Autoimmune Disease of Central Nervous System

Drug clinical trials:

Search ClinicalTrials for Autoimmune Disease of Central Nervous System

Search NIH Clinical Center for Autoimmune Disease of Central Nervous System

Search CenterWatch for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

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Anatomical Context for Autoimmune Disease of Central Nervous System

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Disease of Central Nervous System:

32
Testes, T cells

Animal Models for Autoimmune Disease of Central Nervous System or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Disease of Central Nervous System:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4APOA1, TF, CD40LG, CD79A, TTR, C3
2MP:00053677.6CD40LG, CD79A, IL17A, MMP9, NOS2, C3
3MP:00053847.0PRKAA1, CD40LG, CD79A, IL17A, MMP9, NOS2
4MP:00053876.9APOA1, PRKAA1, CD40LG, CD79A, IL17A, MMP9
5MP:00053976.7C3, APOA1, TF, PRKAA1, CD40LG, CD79A

Publications for Autoimmune Disease of Central Nervous System

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50PubMed
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Articles related to Autoimmune Disease of Central Nervous System:

idTitleAuthorsYear
1
High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. (19969379)
2010
2
Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system. (19657390)
2009
3
Chemokine-like receptor-1 expression by central nervous system-infiltrating leukocytes and involvement in a model of autoimmune demyelinating disease. (19864606)
2009
4
Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. (19494326)
2009
5
Statins in the treatment of central nervous system autoimmune disease. (16860400)
2006
6
Childhood autoimmune neurologic diseases of the central nervous system. (14743647)
2003
7
Complete proteinogram of cerebrospinal fluid and its contribution to the diagnostics of inflammatory and autoimmune diseases of the central nervous system. (14577135)
2003
8
The significance of in-situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. (8397714)
1993
9
T lymphocyte line-mediated experimental allergic encephalomyelitis--a pharmacologic model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease. (3497261)
1987
10
Congenic autoimmune murine models of central nervous system disease in connective tissue disorders. (6625539)
1983

Genetic Variations for Autoimmune Disease of Central Nervous System

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Expression for genes affiliated with Autoimmune Disease of Central Nervous System

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for genes affiliated with Autoimmune Disease of Central Nervous System

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Sources:
29KEGG, 37NCBI BioSystems Database
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Pathways related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4C3, IL17A, CD40LG
2
Hide members
9.3IL17A, CD79A, CD40LG

Compounds for genes affiliated with Autoimmune Disease of Central Nervous System

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.6TTR
2indomethacin44 59 28 1113.5APOA1
3mannan4410.4CD79A
4pge24410.4MMP9
5estrogen4410.2CD79A, TTR
6glutamate4410.2CD40LG, APOA1
7stresson4410.1CD40LG, TTR
8alpha tocopherol4410.1TTR, TF
9sulfolipid i4410.1CD40LG, CD79A
10sandoglobulin4410.0CD79A, CD40LG
11tocopherol449.8TF, APOA1, TTR
12tacrolimus44 49 1111.6IL17A, CD79A, APOA1
13neopterin449.6CD40LG, CD79A, TTR, C3
14guanidine44 11 2411.5TTR, APOA1, NOS2
15valproate449.5APOA1, CD40LG, CD79A
16glutaraldehyde449.5TF, TTR, CD79A, CD40LG
17polyethylene glycol449.4APOA1, TF, CD40LG, CD79A
18dexamethasone44 49 28 1112.4CD40LG, C3, MMP9, CD79A
19aspirin44 49 28 2412.3CD79A, CD40LG, APOA1, TTR
20vitamin a44 11 2411.3APOA1, AMBP, MMP9
21formaldehyde44 2410.2MMP9, CD79A, CD40LG, APOA1
22ribavirin44 49 1111.2TF, CD40LG, MMP9
23vitamin b12449.2TF, CD40LG, CD79A, APOA1, TTR
24thyroxine44 2410.1APOA1, TTR, CD79A, CD40LG, TF
25ns 39844 5910.1MMP9, IL17A, NOS2
26aspartate449.1TTR, CD40LG, AMBP, APOA1
27agar449.0TF, CD40LG, TTR, CD79A
28fenofibrate44 49 1111.0CD40LG, MMP9, APOA1
29folate448.9CD40LG, MMP9, TTR, TF, CD79A
30epinephrine44 11 2410.9TTR, MMP9, CD79A, CD40LG, TF
31paraffin448.9CD40LG, TF, CD79A, MMP9, TTR
32methotrexate44 49 1110.8TF, MMP9, IL17A, CD79A
33dopamine44 28 11 2411.8CD40LG, CD79A, MMP9, TTR, TF
34l-nmma448.8IL17A, MMP9, NOS2
35nifedipine44 49 28 1111.8AMBP, TF, APOA1, MMP9
36genistein44 28 59 2 11 2413.7TTR, MMP9, CD40LG, APOA1, NOS2
37serine448.6PRKAA1, C3, MMP9, AMBP
38ascorbic acid44 249.5APOA1, CD40LG, CD79A, TTR, TF, NOS2
39hyaluronic acid44 249.5AMBP, MMP9, CD79A, CD40LG, TTR
40carbohydrates448.5TF, AMBP, PRKAA1, TTR, CD40LG
41adenylate448.3NOS2, TTR, MMP9, PRKAA1, CD40LG
42vegf448.1TF, CD79A, IL17A, NOS2, MMP9, CD40LG
43n acetylcysteine448.1MMP9, NOS2, CD40LG, CD79A, PRKAA1, TF
44cysteine448.1AMBP, CD40LG, CD79A, MMP9, C3, TTR
45retinoic acid44 249.0APOA1, AMBP, MMP9, CD40LG, CD79A, TTR
46alanine447.8CD79A, TF, APOA1, AMBP, TTR, MMP9
47cyclosporin a44 28 599.7AMBP, TF, CD79A, MMP9, TTR, IL17A
48fibrinogen447.5CD79A, AMBP, MMP9, APOA1, TF, TTR
49lactate447.5AMBP, CD40LG, APOA1, TF, TTR, C3
50creatinine446.6TF, APOA1, AMBP, PRKAA1, MMP9, CD40LG

GO Terms for genes affiliated with Autoimmune Disease of Central Nervous System

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16Gene Ontology
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Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4TF, APOA1
2external side of plasma membraneGO:0098979.3IL17A, CD79A, CD40LG
3extracellular regionGO:0055767.7AMBP, APOA1, TF, MMP9, TTR, C3
4extracellular spaceGO:0056157.4C3, AMBP, APOA1, CD40LG, IL17A, MMP9

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:0421009.5CD79A, CD40LG
2platelet activationGO:0301689.4CD40LG, TF, APOA1
3inflammatory responseGO:0069548.7C3, NOS2, IL17A, CD40LG

Products for genes affiliated with Autoimmune Disease of Central Nervous System

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Disease of Central Nervous System

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet