MCID: ATM007
MIFTS: 25

Autoimmune Disease of Central Nervous System malady

Categories: Neuronal diseases, Immune diseases

Aliases & Classifications for Autoimmune Disease of Central Nervous System

Aliases & Descriptions for Autoimmune Disease of Central Nervous System:

Name: Autoimmune Disease of Central Nervous System 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:0060004

Summaries for Autoimmune Disease of Central Nervous System

Disease Ontology : 12 An autoimmune disease of the central nervous system.

MalaCards based summary : Autoimmune Disease of Central Nervous System is related to white piedra and aortic valve prolapse. An important gene associated with Autoimmune Disease of Central Nervous System is CNTNAP1 (Contactin Associated Protein 1), and among its related pathways/superpathways are L1CAM interactions and Cell adhesion molecules (CAMs). The drugs Prednisone and Azathioprine have been mentioned in the context of this disorder.

Related Diseases for Autoimmune Disease of Central Nervous System

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 white piedra 10.0 CNTN1 NFASC
2 aortic valve prolapse 9.9 CNTN1 NFASC
3 trabecular follicular adenocarcinoma 9.8 CD86 TNFSF8
4 fruit allergy 9.2 CD1E CNTN1 CNTNAP1 DDX41 NFASC TNFSF8
5 cd3zeta deficiency 8.9 CD1E CD86 CNTN1 CNTNAP1 DDX41 NFASC

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to Autoimmune Disease of Central Nervous System

Symptoms & Phenotypes for Autoimmune Disease of Central Nervous System

Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

Drugs for Autoimmune Disease of Central Nervous System (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 650)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
2
Azathioprine Approved Phase 4,Phase 3,Phase 2 446-86-6 2265
3
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
alemtuzumab Approved, Investigational Phase 4,Phase 3,Phase 2 216503-57-0
5
Amitriptyline Approved Phase 4 50-48-6 2160
6
Cyclobenzaprine Approved Phase 4 303-53-7 2895
7
Everolimus Approved Phase 4,Phase 3,Phase 2,Phase 1 159351-69-6 6442177
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
9
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
10
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
11
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
12
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
13
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
14
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
15
4-Aminopyridine Approved Phase 4,Phase 2,Phase 3 504-24-5 1727
16
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 185243-69-0
17
Interferon beta-1b Approved Phase 4,Phase 3,Phase 2,Phase 1 145155-23-3
18
Hydroxychloroquine Approved Phase 4,Phase 3,Phase 2,Phase 1 118-42-3 3652
19
Infliximab Approved Phase 4,Phase 3,Phase 2 170277-31-3
20
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
21
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 3 16590-41-3 5360515
22
Sulfasalazine Approved Phase 4,Phase 3 599-79-1 5353980 5359476
23
Glatiramer Acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147245-92-9 3081884
24
Abatacept Approved Phase 4,Phase 2 332348-12-6 10237
25
Adalimumab Approved Phase 4,Phase 3 331731-18-1 16219006
26
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
27
Interferon beta-1a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 145258-61-3 6438354
28
Dronabinol Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 1972-08-3 16078 2978
29
Ethanol Approved Phase 4,Phase 3,Phase 2 64-17-5 702
30
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 1,Early Phase 1 50-78-2 2244
31
Armodafinil Approved, Investigational Phase 4,Phase 3,Phase 2 112111-43-0
32
Modafinil Approved, Investigational Phase 4,Phase 3,Phase 2 68693-11-8 4236
33
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
34
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 79217-60-0, 59865-13-3 5284373 6435893
35
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
36
Memantine Approved, Investigational Phase 4,Phase 2,Phase 3 19982-08-2 4054
37
Citalopram Approved Phase 4,Phase 3 59729-33-8 2771
38
Iron Approved Phase 4,Early Phase 1 7439-89-6 23925
39
Mitoxantrone Approved, Investigational Phase 4,Phase 2 65271-80-9 4212
40
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
41
Dimethyl fumarate Approved, Investigational Phase 4,Phase 3,Phase 2 624-49-7 637568 5271565
42
Milnacipran Approved Phase 4 92623-85-3 65833
43
Gabapentin Approved, Investigational Phase 4,Phase 2 60142-96-3 3446
44
Nabilone Approved, Investigational Phase 4 51022-71-0 5284592
45
Oxybutynin Approved, Investigational Phase 4 5633-20-5 4634
46
Menthol Approved Phase 4 2216-51-5 16666
47
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
48
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
49
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
50
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073

Interventional clinical trials:

(show top 50) (show all 1229)
id Name Status NCT ID Phase
1 Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis Unknown status NCT01400464 Phase 4
2 CHUSPAN PAN BP Treatment of Polyarteritis Nodosa and Microscopic Polyangiitis Without Poor-Prognosis Factors Unknown status NCT00400075 Phase 4
3 Alemtuzumab for ANCA Associated Refractory Vasculitis Unknown status NCT01405807 Phase 4
4 Immune Response After Human Papillomavirus Vaccination in Patients With Autoimmune Disease Unknown status NCT00815282 Phase 4
5 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4
6 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4
7 A Phase IV Trial of Neuroprotection With ACTH in Acute Optic Neuritis Unknown status NCT01838174 Phase 4
8 Efficacy of Dalfampridine on Upper Extremity Function in Patients With MS Unknown status NCT02259361 Phase 4
9 Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis Unknown status NCT01287715 Phase 4
10 Colecalciferol as an Add-on Treatment to Interferon-beta-1b for Treatment of Multiple Sclerosis (MS) Unknown status NCT01339676 Phase 4
11 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4
12 Phase IV Study, Betaseron Versus Copaxone for Relapsing Remitting or CIS Forms of MS Using Triple Dose Gad 3 T MRI Unknown status NCT00176592 Phase 4
13 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
14 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4
15 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4
16 Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial Completed NCT01085318 Phase 4
17 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4
18 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4
19 Pharmacokinetics of DMF and the Effects of DMF on Exploratory Biomarkers Completed NCT02683863 Phase 4
20 Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis Completed NCT01207453 Phase 4
21 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4
22 6-year Antibody Check After Third Vaccination Against Japanese Encephalitis Completed NCT02039440 Phase 4
23 Short Term Efficacy of a Starting Dose of 12.5 mg of Prednisone in Polymyalgia Rheumatica Patients Completed NCT01169597 Phase 4
24 Efficacy and Safety Evaluation of Nabilone as Adjunctive Therapy to Gabapentin for the Management of Neuropathic Pain in Multiple Sclerosis Completed NCT00480181 Phase 4
25 Anti-TNF Agents for the Treatment of Rheumatoid Arthritis Completed NCT00837434 Phase 4
26 Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications Completed NCT01834586 Phase 4
27 Clinical Study of Solifenacin Succinate in Patients With Bladder Symptoms Due to Spinal Cord Injury or Multiple Sclerosis Completed NCT00629642 Phase 4
28 A Study to Evaluate the Impact on Skin (Injection Site) Reactions of Using Alcohol Wipes Prior to Daily Injections of Copaxone®. Completed NCT00220922 Phase 4
29 Evaluation of the Efficacy of Cesamet™ for the Treatment of Pain in Patients With Multiple Sclerosis Completed NCT00381264 Phase 4
30 A Study of the Effect on Pain Control of Treatment With Fentanyl, Administered Through the Skin, in Patients With Rheumatoid Arthritis or Osteoarthritis Completed NCT00524160 Phase 4
31 ULTRACET (Tramadol Hydrochloride and Acetaminophen) for the Treatment of Rheumatoid Arthritis Pain. Completed NCT00246168 Phase 4
32 Efficacy and Safety of Buprenorphine Transdermal Patch in Non-cancer Pain of Moderate Intensity Completed NCT02519387 Phase 4
33 Evaluation Of Efficacy And Safety Of Norspan In Moderate To Severe Pain Due To Osteoarthritis, Rheumatoid Arthritis, Joint/Muscle Pain Completed NCT01961271 Phase 4
34 Influence of Diabetes on Tramadol Pharmacokinetics Completed NCT02246712 Phase 4
35 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4
36 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4
37 Levetiracetam in Central Pain in Multiple Sclerosis(MS) Completed NCT00423527 Phase 4
38 A Study Comparing Shared Solutions® Plus MS Center Support Versus Shared Solutions® Alone Completed NCT00240006 Phase 4
39 A 12 -Month, Open-label, Multi-center Study to Explore the Health Outcomes of FTY720 Completed NCT01578330 Phase 4
40 AVONEX® Combination Trial - "ACT" Completed NCT00112034 Phase 4
41 Safety/Effectiveness of Adding Monthly Dexamethasone to Weekly Avonex for MS Completed NCT00232193 Phase 4
42 Evaluation of Patient Reported Outcomes in RRMS Patients Candidates for MS Therapy Change and Transitioned to Fingolimod 0.5 mg (EPOC) Completed NCT01534182 Phase 4
43 Is IFN-beta Treatment in MS Useful After a Washout Period in Patients With Neutralizing Antibodies to Interferon Beta Completed NCT00493116 Phase 4
44 A Study to Evaluate the Long Term Safety and Effectiveness of Novantrone Therapy Followed by Copaxone Treatment for Multiple Sclerosis Completed NCT00203086 Phase 4
45 Safety of Xeomin for Lower Limb Spasticity in Multiple Sclerosis Patients Completed NCT01968902 Phase 4
46 Fingolimod -Response According to Coping - Evaluation Completed NCT01420055 Phase 4
47 Safety and Efficacy Study of Doxycycline in Combination With Interferon-B-1a to Treat Multiple Sclerosis Completed NCT00246324 Phase 4
48 A 6-month, Randomized, Open-label, Patient OutComes, Safety and Tolerability Study of Fingolimod (FTY720) 0.5 mg/Day vs. Comparator in Patients With Relapsing Forms of Multiple Sclerosis Completed NCT01216072 Phase 4
49 Patients With Relapse Remitting Multiple Sclerosis (RRMS): Candidates for MS Therapy Change Completed NCT01317004 Phase 4
50 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4

Search NIH Clinical Center for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

Anatomical Context for Autoimmune Disease of Central Nervous System

Publications for Autoimmune Disease of Central Nervous System

Variations for Autoimmune Disease of Central Nervous System

Expression for Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for Autoimmune Disease of Central Nervous System

Pathways related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.23 CNTN1 CNTNAP1 NFASC
2 11.09 CD86 CNTN1 CNTNAP1 NFASC
3 10.93 CD86 TNFSF8

GO Terms for Autoimmune Disease of Central Nervous System

Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.7 CD1E CD86 CNTN1 CNTNAP1 DDX41 NFASC
2 myelin sheath GO:0043209 9.13 CNTN1 CNTNAP1 NFASC
3 paranode region of axon GO:0033270 8.62 CNTNAP1 NFASC

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.5 CNTN1 CNTNAP1 NFASC
2 immune response GO:0006955 9.33 CD1E CD86 TNFSF8
3 neuron projection development GO:0031175 9.26 CNTN1 CNTNAP1
4 paranodal junction assembly GO:0030913 8.96 CNTNAP1 NFASC
5 protein localization to paranode region of axon GO:0002175 8.62 CNTNAP1 NFASC

Sources for Autoimmune Disease of Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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