MCID: ATM007
MIFTS: 22

Autoimmune Disease of Central Nervous System malady

Neuronal category

Summaries for Autoimmune Disease of Central Nervous System

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 An autoimmune disease of the central nervous system.

MalaCards: Autoimmune Disease of Central Nervous System is related to malaria and dementia. An important gene associated with Autoimmune Disease of Central Nervous System is C3 (complement component 3), and among its related pathways are Leishmaniasis and B cell receptor signaling pathway. The compounds norepinephrine and indomethacin have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Aliases & Classifications for Autoimmune Disease of Central Nervous System

Sources:
8Disease Ontology
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

autoimmune disease of central nervous system 8


External Ids:

Disease Ontology8 DOID:0060004

Related Diseases for Autoimmune Disease of Central Nervous System

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the nervous system disease family:

autoimmune disease of central nervous system autoimmune disease of the nervous system
central nervous system disease congenital nervous system abnormality

Diseases related to Autoimmune Disease of Central Nervous System via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1malaria10.0AMBP
2dementia10.0AMBP
3hypothyroidism10.0TTR
4age related macular degeneration10.0C3
5myocardial infarction10.0APOA1
6thromboembolism10.0APOA1
7coronary heart disease10.0APOA1
8guillain-barre syndrome10.0CD40LG
9polycystic ovary syndrome10.0APOA1
10arteriosclerosis10.0APOA1
11essential hypertension10.0APOA1
12inflammatory bowel disease10.0CD79A
13purpura10.0CD79A
14pemphigus10.0CD79A
15sinusitis10.0CD79A
16otitis media10.0CD79A
17rhinitis10.0CD79A
18thyroiditis10.0CD79A
19prostatitis10.0CD79A
20conjunctivitis10.0CD79A
21bronchitis10.0CD79A
22pertussis10.0CD79A
23lyme disease10.0CD40LG
24peripheral vascular disease10.0CD79A
25brucellosis10.0CD79A
26mumps10.0CD79A
27psoriasis10.0IL17A
28myelodysplastic syndromes10.0TF
29hyperthyroxinemia10.0TTR
30collagenous colitis10.0NOS2
31endometriosis10.0IL17A
32allergic rhinitis10.0IL17A
33celiac disease10.0CD79A
34bronchiectasis10.0CD79A
35myocarditis10.0NOS2
36diabetic retinopathy10.0NOS2
37influenza10.0CD79A
38cd40 ligand deficiency10.0CD40LG
39gastrointestinal system disease10.0NOS2
40alcohol abuse10.0TF
41synovitis10.0IL17A
42wilson disease10.0TF
43gingivitis10.0IL17A
44uveitis10.0IL17A
45protein-losing enteropathy10.0TF
46candidiasis10.0CD79A
47cryptosporidiosis10.0CD79A
48eosinophilia10.0CD79A
49hyperglycemia10.0NOS2
50hepatitis10.0TTR, CD40LG

Graphical network of the top 20 diseases related to Autoimmune Disease of Central Nervous System:



Diseases related to autoimmune disease of central nervous system

Clinical Features for Autoimmune Disease of Central Nervous System

Drugs & Therapeutics for Autoimmune Disease of Central Nervous System

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Disease of Central Nervous System

Drug clinical trials:

Search ClinicalTrials for Autoimmune Disease of Central Nervous System

Search NIH Clinical Center for Autoimmune Disease of Central Nervous System

Search CenterWatch for Autoimmune Disease of Central Nervous System

Genetic Tests for Autoimmune Disease of Central Nervous System

Anatomical Context for Autoimmune Disease of Central Nervous System

Animal Models for Autoimmune Disease of Central Nervous System or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Autoimmune Disease of Central Nervous System:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.4APOA1, TF, CD40LG, CD79A, TTR, C3
2MP:00053677.6CD40LG, CD79A, IL17A, MMP9, NOS2, C3
3MP:00053847.0PRKAA1, CD40LG, CD79A, IL17A, MMP9, NOS2
4MP:00053876.9APOA1, PRKAA1, CD40LG, CD79A, IL17A, MMP9
5MP:00053976.7C3, APOA1, TF, PRKAA1, CD40LG, CD79A

Publications for Autoimmune Disease of Central Nervous System

Genetic Variations for Autoimmune Disease of Central Nervous System

Expression for genes affiliated with Autoimmune Disease of Central Nervous System

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Disease of Central Nervous System

Search GEO for disease gene expression data for Autoimmune Disease of Central Nervous System.

Pathways for genes affiliated with Autoimmune Disease of Central Nervous System

Sources:
30KEGG, 38NCBI BioSystems Database
See all sources

Pathways related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4C3, IL17A, CD40LG
2
Hide members
9.3IL17A, CD79A, CD40LG

Compounds for genes affiliated with Autoimmune Disease of Central Nervous System

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.6TTR
2indomethacin45 60 29 1113.5APOA1
3mannan4510.4CD79A
4pge24510.4MMP9
5estrogen4510.2CD79A, TTR
6glutamate4510.2CD40LG, APOA1
7stresson4510.1CD40LG, TTR
8alpha tocopherol4510.1TTR, TF
9sulfolipid i4510.1CD40LG, CD79A
10sandoglobulin4510.0CD79A, CD40LG
11tocopherol459.8TF, APOA1, TTR
12tacrolimus45 50 1111.6IL17A, CD79A, APOA1
13neopterin459.6CD40LG, CD79A, TTR, C3
14guanidine45 11 2411.5TTR, APOA1, NOS2
15valproate459.5APOA1, CD40LG, CD79A
16glutaraldehyde459.5TF, TTR, CD79A, CD40LG
17polyethylene glycol459.4APOA1, TF, CD40LG, CD79A
18dexamethasone45 50 29 1112.4CD40LG, C3, MMP9, CD79A
19aspirin45 50 29 2412.3CD79A, CD40LG, APOA1, TTR
20vitamin a45 11 2411.3APOA1, AMBP, MMP9
21formaldehyde45 2410.2MMP9, CD79A, CD40LG, APOA1
22ribavirin45 50 1111.2TF, CD40LG, MMP9
23vitamin b12459.2TF, CD40LG, CD79A, APOA1, TTR
24thyroxine45 2410.1APOA1, TTR, CD79A, CD40LG, TF
25ns 39845 6010.1MMP9, IL17A, NOS2
26aspartate459.1TTR, CD40LG, AMBP, APOA1
27agar459.0TF, CD40LG, TTR, CD79A
28fenofibrate45 50 1111.0CD40LG, MMP9, APOA1
29folate458.9CD40LG, MMP9, TTR, TF, CD79A
30epinephrine45 11 2410.9TTR, MMP9, CD79A, CD40LG, TF
31paraffin458.9CD40LG, TF, CD79A, MMP9, TTR
32methotrexate45 50 1110.8TF, MMP9, IL17A, CD79A
33dopamine45 29 11 2411.8CD40LG, CD79A, MMP9, TTR, TF
34l-nmma458.8IL17A, MMP9, NOS2
35nifedipine45 50 29 1111.8AMBP, TF, APOA1, MMP9
36genistein45 29 60 2 11 2413.7TTR, MMP9, CD40LG, APOA1, NOS2
37serine458.6PRKAA1, C3, MMP9, AMBP
38ascorbic acid45 249.5APOA1, CD40LG, CD79A, TTR, TF, NOS2
39hyaluronic acid45 249.5AMBP, MMP9, CD79A, CD40LG, TTR
40carbohydrates458.5TF, AMBP, PRKAA1, TTR, CD40LG
41adenylate458.3NOS2, TTR, MMP9, PRKAA1, CD40LG
42vegf458.1TF, CD79A, IL17A, NOS2, MMP9, CD40LG
43n acetylcysteine458.1MMP9, NOS2, CD40LG, CD79A, PRKAA1, TF
44cysteine458.1AMBP, CD40LG, CD79A, MMP9, C3, TTR
45retinoic acid45 249.0APOA1, AMBP, MMP9, CD40LG, CD79A, TTR
46alanine457.8CD79A, TF, APOA1, AMBP, TTR, MMP9
47cyclosporin a45 29 609.7AMBP, TF, CD79A, MMP9, TTR, IL17A
48fibrinogen457.5CD79A, AMBP, MMP9, APOA1, TF, TTR
49lactate457.5AMBP, CD40LG, APOA1, TF, TTR, C3
50creatinine456.6TF, APOA1, AMBP, PRKAA1, MMP9, CD40LG

GO Terms for genes affiliated with Autoimmune Disease of Central Nervous System

Sources:
16Gene Ontology
See all sources

Cellular components related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.4TF, APOA1
2external side of plasma membraneGO:0098979.3IL17A, CD79A, CD40LG
3extracellular regionGO:0055767.7AMBP, APOA1, TF, MMP9, TTR, C3
4extracellular spaceGO:0056157.4C3, AMBP, APOA1, CD40LG, IL17A, MMP9

Biological processes related to Autoimmune Disease of Central Nervous System according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:0421009.5CD79A, CD40LG
2platelet activationGO:0301689.4CD40LG, TF, APOA1
3inflammatory responseGO:0069548.7C3, NOS2, IL17A, CD40LG

Products for genes affiliated with Autoimmune Disease of Central Nervous System

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Disease of Central Nervous System

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet