MCID: ATM020
MIFTS: 30

Autoimmune Enteropathy malady

Rare diseases, Gastrointestinal diseases categories
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Summaries for Autoimmune Enteropathy

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Autoimmune enteropathy is a rare condition that happens usually to infants, young children and sometimes... more...

MalaCards: Autoimmune Enteropathy is related to arthritis and rheumatoid arthritis. An important gene associated with Autoimmune Enteropathy is USH1C (Usher syndrome 1C (autosomal recessive, severe)), and among its related pathways are Leishmaniasis and Cytokine production by Th17 cells in CF. The compounds nmda and sb 203580 have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and t cells, and related mouse phenotype integument.

Aliases & Classifications for Autoimmune Enteropathy

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Sources:
43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

autoimmune enteropathy 43 62


Related Diseases for Autoimmune Enteropathy

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Enteropathy family:

Autoimmune Enteropathy Type 3 Autoimmune Enteropathy Type 2

Diseases related to Autoimmune Enteropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.0CSN1S1, IL17A, FOXP3
2rheumatoid arthritis30.0IL17A, CSN1S1, FOXP3
3thymoma10.3
4hepatitis10.2
5vasculitis10.2
6venous thrombosis10.2
7autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome10.2
8severe immune-mediated enteropathy10.2
9autoimmune enteropathy type 310.2
10autoimmune enteropathy type 210.2
11hepatitis c10.1
12atrophic gastritis10.1
13celiac disease10.1
14bullous pemphigoid10.1
15autoimmune hepatitis10.1
16duodenitis10.1
17cerebritis10.1
18diarrhea10.1
19gastritis10.1
20glomerulonephritis10.1
21lymphopenia10.1
22schimke immunoosseous dysplasia10.1
23enteropathy-associated t-cell lymphoma10.1
24immunodysregulation, polyendocrinopathy and enteropathy x-linked10.1
25dermatitis10.0FOXP3, IL17A
26hypersensitivity reaction type ii disease10.0FOXP3, IL17A
27food allergy10.0CSN1S1, FOXP3
28allergic rhinitis10.0FOXP3, IL17A
29diphtheria10.0FOXP3, CSN1S1
30atopic dermatitis10.0IL17A, CSN1S1
31usher syndrome10.0USH1C, LNX1
32cholera10.0IL17A, CSN1S1
33cork-handlers' disease10.0CSN1S1, IL17A
34inflammatory bowel disease10.0IL17A, FOXP3
35multiple sclerosis10.0FOXP3, IL17A
36ulcerative colitis10.0CSN1S1, IL17A
37t-cell leukemia10.0FOXP3, LNX1
38asthma10.0IL17A, FOXP3, CSN1S1
39cystic fibrosis10.0IL17A, LNX1
40systemic lupus erythematosus10.0CSN1S1, IL17A

Graphical network of the top 20 diseases related to Autoimmune Enteropathy:



Diseases related to autoimmune enteropathy

Symptoms for Autoimmune Enteropathy

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Drugs & Therapeutics for Autoimmune Enteropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Autoimmune Enteropathy

Search NIH Clinical Center for Autoimmune Enteropathy

Genetic Tests for Autoimmune Enteropathy

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Anatomical Context for Autoimmune Enteropathy

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Sources:
33MalaCards
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MalaCards organs/tissues related to Autoimmune Enteropathy:

33
Kidney, Thyroid, T cells, Bone

Animal Models for Autoimmune Enteropathy or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Autoimmune Enteropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.7CSN1S1, FOXP3, USH1C

Publications for Autoimmune Enteropathy

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Sources:
52PubMed
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Articles related to Autoimmune Enteropathy:

(show top 50)    (show all 63)
idTitleAuthorsYear
1
Abatacept: a new treatment option for refractory adult autoimmune enteropathy. (24045285)
2014
2
Pediatric autoimmune enteropathy: an entity frequently associated with immunodeficiency disorders. (24051695)
2013
3
A Case of Isolated Autoimmune Enteropathy Associated with Autoantibodies to a Novel 28 kilodalton Duodenal Antigen. (23969534)
2013
4
Autoimmune enteropathy: a review and update of clinical management. (22810979)
2012
5
Enteropathy-associated T-cell lymphoma complicating an autoimmune enteropathy. (22226659)
2012
6
Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel intraepithelial lymphocytosis: case report and literature review. (22126605)
2011
7
Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. (19940509)
2010
8
Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy. (20537998)
2010
9
Cerebral venous thrombosis in autoimmune enteropathy. (20186248)
2010
10
Autoimmune enteropathy associated with cessation of interferon-alpha therapy in chronic hepatitis C. (19639409)
2010
11
Anti-goblet cell antibodies for the diagnosis of autoimmune enteropathy? (19956142)
2009
12
Autoimmune enteropathy in Swedish children, 1985-2002: a call for strict diagnostic criteria. (18609171)
2008
13
Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. (18420833)
2008
14
Adult autoimmune enteropathy. (18300339)
2008
15
Adult autoimmune enteropathy: Mayo Clinic Rochester experience. (17683994)
2007
16
Severe FOXP3+ and naA^ve T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency. (17484867)
2007
17
Association between thymoma and autoimmune enteropathy in adults. (16996380)
2006
18
Enteropathy with loss of enteroendocrine and paneth cells in a patient with immune dysregulation: a case of adult autoimmune enteropathy. (16613334)
2006
19
Autoimmune enteropathy and rheumatoid arthritis: a new association in the field of autoimmunity. (16920048)
2006
20
Adult-onset autoimmune enteropathy in the setting of thymoma successfully treated with infliximab. (15906770)
2005
21
Management of severe refractory adult autoimmune enteropathy with infliximab and tacrolimus. (15785040)
2005
22
Autoimmune enteropathy: molecular concepts. (15703687)
2004
23
Adult autoimmune enteropathy treated successfully with tacrolimus. (14581765)
2003
24
Remission of severe autoimmune enteropathy after treatment with high-dose cyclophosphamide. (12717089)
2003
25
Autoimmune enteropathy. (12952510)
2003
26
Autoimmune enteropathy and colitis in an adult patient. (12924654)
2003
27
Autoimmune enteropathy in an adult with autoimmune multisystemic involvement. (12374224)
2002
28
Mechanisms of villous atrophy in autoimmune enteropathy and coeliac disease. (11982595)
2002
29
Possible autoimmune enteropathy found in autistic children. (12020535)
2002
30
Autoimmune enteropathy in a child: response to infliximab therapy. (11964960)
2002
31
Simultaneous occurrence of autoimmune enteropathy and recurrent deep venous thrombosis. (10749421)
2000
32
Autoimmune enteropathy. (9841709)
1999
33
Thymoma-associated autoimmune enteropathy. A report of two cases. (10587704)
1999
34
Autoimmune enteropathy with distinct mucosal features in T-cell activation deficiency: the contribution of T cells to the mucosal lesion. (10204503)
1999
35
Autoimmune enteropathy with goblet cell antibodies. (10692917)
1999
36
Identification of an autoimmune enteropathy-related 75-kilodalton antigen. (10500064)
1999
37
Autoimmune enteropathy in infants. Pathological study of the disease in two familial cases. (9849864)
1998
38
A 75-kD autoantigen recognized by sera from patients with X-linked autoimmune enteropathy associated with nephropathy. (9528893)
1998
39
Autoimmune enteropathy in Schimke immunoosseous dysplasia. (9632175)
1998
40
Autoimmune enteropathy with severe atrophic gastritis and colitis in an adult: proposal of a generalized autoimmune disorder of the alimentary tract. (9712235)
1998
41
Autoimmune enteropathy in a pediatric patient: partial response to tacrolimus therapy. (9152557)
1997
42
Autoimmune enteropathy in adults. (9314894)
1997
43
Systemic vasculitis complicating infantile autoimmune enteropathy. (7618925)
1995
44
Clinical quiz. A 1.5 year-old boy with autoimmune enteropathy. (7742212)
1995
45
Autoimmune enteropathy with anti-goblet cell antibodies. (7557954)
1995
46
Familial autoimmune enteropathy with circulating anti-bullous pemphigoid antibodies and chronic autoimmune hepatitis. (7996356)
1994
47
Autoimmune enteropathy, anti-tubular basement membrane antibodies, and glomerulonephritis. (1552411)
1992
48
LFA-1 and ICAM-1 molecule expression in jejunal mucosa from children with autoimmune enteropathy. (1361864)
1992
49
Response to autoimmune enteropathy to cyclosporin A therapy. (1752480)
1991
50
Successful treatment of autoimmune enteropathy with cyclosporine. (2246696)
1990

Variations for Autoimmune Enteropathy

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Expression for genes affiliated with Autoimmune Enteropathy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Enteropathy

Search GEO for disease gene expression data for Autoimmune Enteropathy.

Pathways for genes affiliated with Autoimmune Enteropathy

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 55Reactome
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Pathways related to Autoimmune Enteropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3IL17A, FOXP3
2
Show member pathways
9.3IL17A, FOXP3

Compounds for genes affiliated with Autoimmune Enteropathy

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Autoimmune Enteropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nmda45 2910.1CSN1S1, LNX1
2sb 20358045 6110.1CSN1S1, IL17A
3pyrophosphate45 2410.0LNX1, CSN1S1
4ly294002458.7CSN1S1, IL17A
5pge2458.6CSN1S1, IL17A, FOXP3
6tyrosine458.5CSN1S1, IL17A, LNX1

GO Terms for genes affiliated with Autoimmune Enteropathy

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Products for genes affiliated with Autoimmune Enteropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Enteropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet