MCID: ATM010
MIFTS: 60

Autoimmune Hemolytic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases categories

Summaries for Autoimmune Hemolytic Anemia

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9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hemolytic anemia and leukemia. An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Malaria and Creation of C4 and C2 activators. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds tuberculin and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:9 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:66 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM:48 205700

Aliases & Classifications for Autoimmune Hemolytic Anemia

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 48OMIM, 59SNOMED-CT, 28ICD9CM, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

autoimmune hemolytic anemia 9 44 11 46 63
idiopathic autoimmune hemolytic anemia 44
familial auto-immune hemolytic anemia 44
acquired autoimmune hemolytic anemia 44
autoimmune hemolytic anemia nos 9
autoimmune haemolytic anaemias 9
autoimmune haemolytic anaemia 9
autoimmune hemolytic anemias 9
anemia hemolytic autoimmune 44
immuno-hemolytic anemia 44


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Disease Ontology9 DOID:718
MeSH36 D000744
OMIM48 205700
ICD9CM28 283.0
NCIt41 C34378

Related Diseases for Autoimmune Hemolytic Anemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hemolytic Anemia family:

autoimmune hemolytic anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia32.2G6PD, HP, CD59, CD55
2leukemia31.3GYPA, HP, CD40LG, CD59, CD55
3chronic lymphocytic leukemia31.3CD55, CD59, CD40LG
4thrombocytopenia31.2CD40LG, HP
5hepatitis c31.1CD40LG, HP
6systemic lupus erythematosus30.9CD40LG, CD59, CD55
7hereditary spherocytosis30.8GYPA, G6PD
8glomerulonephritis30.7CD40LG, CD59, CD55
9nephritis30.6CD55, CD40LG
10viral hepatitis30.6G6PD
11arthritis30.4CD55, CD59, HP
12myelodysplastic syndromes30.4GYPA, CD59, CD55
13graves' disease30.4CD59, CD55
14hemoglobinuria30.4G6PD, HP, CD59, CD55
15congenital hemolytic anemia30.4G6PD, HP
16sickle cell disease30.3HP, G6PD
17pancytopenia30.3HP, CD55
18malaria30.3HP, GYPA, G6PD
19lupus nephritis30.3CD55, CD40LG
20diabetes mellitus30.3CD40LG, HP, G6PD
21autoimmune thyroiditis30.2CD55, CD59
22chronic myeloid leukemia30.2CD55, CD59, G6PD
23pancreatic cancer30.2CD55, CD59, HP
24rheumatoid arthritis30.1HP, CD40LG, CD59, CD55
25paroxysmal nocturnal hemoglobinuria30.1CD55, CD59, HP, G6PD
26hepatitis11.0
27pure red-cell aplasia10.7
28purpura10.7
29mixed-type autoimmune hemolytic anemia10.7
30lupus erythematosus10.6
31primary biliary cirrhosis10.6
32evans' syndrome10.6
33antiphospholipid syndrome10.6
34ulcerative colitis10.6
35b-cell chronic lymphocytic leukemia10.6
36drug-induced autoimmune hemolytic anemia10.6
37common variable immunodeficiency10.5
38hepatitis c virus10.5
39crohn's disease10.5
40splenic infarction10.5
41autoimmune hepatitis10.5
42hepatitis a10.5
43diffuse large b-cell lymphoma10.5
44hodgkin's lymphoma10.5
45non-hodgkin lymphoma10.5
46b-cell lymphomas10.5
47warm antibody hemolytic anemia10.5
48hematopoietic stem cell transplantation10.5
49hemophagocytic lymphohistiocytosis10.4
50hepatitis e10.4

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Symptoms for Autoimmune Hemolytic Anemia

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Sources:
48OMIM
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Clinical features from OMIM:

205700

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Search CenterWatch for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Autoimmune Hemolytic Anemia

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Anatomical Context for Autoimmune Hemolytic Anemia

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34MalaCards
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MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

34
Testes, T cells, B cells, Liver, Bone marrow, Bone, Thyroid, Kidney, Heart, Nk cells, Monocytes, Myeloid, Colon, Brain, Pancreas

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD55, CD59, CD40LG, HP, T
2MP:00053977.7CD55, CD59, CD40LG, HP, G6PD
3MP:00053767.1T, G6PD, HP, CD40LG, CD59, CD55
4MP:00107686.9T, G6PD, HP, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

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53PubMed
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Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
2
Autoimmune hemolytic anemia occurred in burn patient: A case report. (24045069)
2013
3
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
4
Megadose Methyl-Prednisolone (MDMP) for Autoimmune Hemolytic Anemia. (24385798)
2013
5
Rare coexistence of Rosai-Dorfman disease and nodal marginal zone lymphoma complicated by severe life-threatening autoimmune hemolytic anemia. (23270580)
2013
6
Autoimmune hemolytic anemia in a patient with Malaria. (24014948)
2013
7
A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child. (24046918)
2013
8
Megadose Methylprednisolone (MDMP) Treatment in a Patient with Autoimmune Hemolytic Anemia (AIHA) Resistant to Conventional Corticosteroid Administration: A Case Report. (24385786)
2013
9
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
10
B-cell receptor configuration and adverse cytogenetics are associated with autoimmune hemolytic anemia in chronic lymphocytic leukemia. (23115077)
2013
11
Characterization of direct antiglobulin test-negative autoimmune hemolytic anemia: a study of 154 cases. (23169533)
2013
12
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
13
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
14
Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia. (22851939)
2012
15
IgA-induced autoimmune hemolytic anemia in a patient with antiphospholipid syndrome. (22988389)
2012
16
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
17
Autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia is associated with IgVH status. (20410184)
2010
18
Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. (20445515)
2010
19
Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study. (20625007)
2010
20
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
21
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
22
Primary Biliary Cirrhosis-Related Autoimmune Hemolytic Anemia: Three Case Reports and Review of the Literature. (21103282)
2009
23
Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. (19578637)
2009
24
Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. (18954403)
2009
25
Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly. (18452105)
2008
26
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
27
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
28
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
29
Living donor liver transplantion for primary biliary cirrhosis with autoimmune hemolytic anemia: a case report. (17415648)
2007
30
Cold agglutinin induced autoimmune hemolytic anemia and NK-cell leukemia: a new association. (17301976)
2007
31
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
32
Warm autoimmune hemolytic anemia is an IgM-IgG immune complex disease. (16242913)
2005
33
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
34
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
35
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
36
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
37
Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. (14563012)
2003
38
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
39
Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. (12483369)
2002
40
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
41
Autoimmune hemolytic anemia caused by IgG lambda-monotypic cold agglutinins of anti-Pr specificity after rubella infection. (11316899)
2001
42
Acute parvovirus B19 infection as a cause of autoimmune hemolytic anemia. (10980646)
2000
43
Open heart surgery in a patient with autoimmune hemolytic anemia. (10402776)
1999
44
Warm autoimmune hemolytic anemia associated with an IgM autoanti-Ge. (15377210)
1998
45
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
46
High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia. (9267883)
1997
47
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
48
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
49
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
50
The role of anticardiolipin autoantibodies in the pathogenesis of autoimmune hemolytic anemia in systemic lupus erythematosus. (8014933)
1993

Variations for Autoimmune Hemolytic Anemia

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Expression for genes affiliated with Autoimmune Hemolytic Anemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

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Sources:
51PathCards, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 58SinoBiological
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Pathways related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, GYPA
2
Show member pathways
9.0CD55, CD59
3
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.0CD55, CD59
4
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.0CD55, CD59
58.6GYPA, CD55, CD59

Compounds for genes affiliated with Autoimmune Hemolytic Anemia

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1tuberculin4610.1CD40LG, HP
223-diphosphoglycerate4610.0G6PD, HP
3thiobarbituric acid4610.0G6PD, HP
4zinc protoporphyrin4610.0G6PD, HP
5sulfamethoxazole52 46 1211.9CD40LG, G6PD
6tocopherol469.9HP, G6PD
7starch469.9HP, G6PD
8cellulose acetate469.9HP, G6PD
9galalpha(1,3)gal469.9CD40LG, CD59
10glutaraldehyde469.8CD40LG, G6PD
11hypoxanthine46 25 1211.7GYPA, G6PD
12neopterin469.7CD40LG, HP
13malondialdehyde469.6HP, G6PD
14sulfasalazine30 46 52 1212.6CD40LG, HP, G6PD
15lactose46 1210.6CD40LG, HP, G6PD
16ribavirin46 52 1211.6CD40LG, HP, G6PD
17vitamin b12469.6G6PD, HP, CD40LG
18polyethylene glycol469.6CD40LG, HP, G6PD
19thyroxine46 2510.6CD40LG, HP, G6PD
20folate469.6CD40LG, HP, G6PD
21epinephrine46 25 1211.5G6PD, HP, CD40LG
22ascorbic acid46 2510.5CD40LG, HP, G6PD
23hirudin469.5CD40LG, CD55
24ganglioside469.4CD59, CD40LG
25fludarabine46 52 1211.4CD55, CD40LG
26fitc469.3CD55, CD59
27polysaccharide469.2CD55, CD40LG, HP
28anaphylatoxin469.1CD55, CD59, HP
29adenylate469.1G6PD, HP, CD40LG
30sucrose46 25 1211.0HP, CD59, CD55
31atorvastatin46 52 30 25 1213.0CD55, CD59, CD40LG
32glycolipid469.0GYPA, CD59, CD55
33aspirin46 52 30 2512.0G6PD, HP, CD40LG, CD59
34heparin46 30 25 1212.0CD55, CD40LG, HP
35lactate469.0G6PD, HP, CD40LG, CD59
36phospholipid469.0HP, CD59, CD55
37iron46 259.9CD55, CD59, HP
38cisplatin46 52 62 1211.9G6PD, CD40LG, CD55
39alanine468.8CD55, CD40LG, HP, GYPA
40actinomycin d468.8CD55, CD40LG, HP, G6PD
41creatinine468.8G6PD, HP, CD40LG, CD55
42aspartate468.8G6PD, HP, CD40LG, CD55
43rituximab46 52 1210.7CD55, CD59, CD40LG, HP
44estrogen468.7G6PD, HP, CD40LG, CD55
45cyclosporin a46 30 6210.7HP, CD40LG, CD59, CD55
46sialic acid468.7GYPA, HP, CD59, CD55
47atp46 309.5G6PD, HP, CD59, CD55
48glucose468.5G6PD, HP, CD59, CD55
49lipid468.1CD55, CD59, HP, GYPA, G6PD
50serine468.0CD55, CD40LG, HP, G6PD

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

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17Gene Ontology
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Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1CD55, CD59, HP, G6PD

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.0CD55, CD59

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.2CD55, GYPA

Products for genes affiliated with Autoimmune Hemolytic Anemia

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  • Antibodies
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Sources for Autoimmune Hemolytic Anemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet