MCID: ATM010
MIFTS: 62

Autoimmune Hemolytic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Metabolic diseases categories
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Summaries for Autoimmune Hemolytic Anemia

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NIH Rare Diseases:42 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards based summary: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hemolytic anemia and thrombocytopenia, and has symptoms including An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Malaria and Creation of C4 and C2 activators. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds tuberculin and thiobarbituric acid have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:65 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM:46 205700

Aliases & Classifications for Autoimmune Hemolytic Anemia

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Autoimmune Hemolytic Anemia, Aliases & Descriptions:

Name: Autoimmune Hemolytic Anemia 8 42 10 44 62
Idiopathic Autoimmune Hemolytic Anemia 42 62
Familial Auto-Immune Hemolytic Anemia 42 62
Acquired Autoimmune Hemolytic Anemia 42 62
 
Autoimmune Haemolytic Anaemia 8 62
Anemia Hemolytic Autoimmune 42 62
Immuno-Hemolytic Anemia 42 62
Autoimmune Hemolytic Anemia Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:718
MeSH34 D000744
OMIM46 205700
ICD9CM27 283.0
NCIt39 C34378

Related Diseases for Autoimmune Hemolytic Anemia

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Diseases in the Autoimmune Hemolytic Anemia family:

Hemolytic Anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 232)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia31.8G6PD, HP, CD59, CD55
2thrombocytopenia31.4CD40LG, HP
3hepatitis c31.3CD40LG, HP
4chronic lymphocytic leukemia31.2CD55, CD59, CD40LG
5viral hepatitis31.1G6PD
6hereditary spherocytosis31.1GYPA, G6PD
7leukemia30.8GYPA, HP, CD40LG, CD59, CD55
8systemic lupus erythematosus30.7CD40LG, CD59, CD55
9congenital hemolytic anemia30.7G6PD, HP
10nephritis30.7CD55, CD40LG
11sickle cell disease30.6HP, G6PD
12glomerulonephritis30.6CD40LG, CD59, CD55
13pancytopenia30.5HP, CD55
14malaria30.4HP, GYPA, G6PD
15arthritis30.4CD55, CD59, HP
16myelodysplastic syndromes30.4GYPA, CD59, CD55
17lupus nephritis30.4CD55, CD40LG
18diabetes mellitus30.3CD40LG, HP, G6PD
19autoimmune thyroiditis30.2CD55, CD59
20graves' disease30.2CD59, CD55
21hemoglobinuria30.0G6PD, HP, CD59, CD55
22chronic myeloid leukemia30.0CD55, CD59, G6PD
23pancreatic cancer30.0CD55, CD59, HP
24rheumatoid arthritis29.8HP, CD40LG, CD59, CD55
25hepatitis11.0
26pure red-cell aplasia10.8
27purpura10.7
28mixed-type autoimmune hemolytic anemia10.7
29lupus erythematosus10.6
30primary biliary cirrhosis10.6
31hematopoietic stem cell transplantation10.6
32ulcerative colitis10.6
33antiphospholipid syndrome10.6
34evans' syndrome10.6
35colitis10.6
36drug-induced autoimmune hemolytic anemia10.6
37b-cell lymphomas10.5
38common variable immunodeficiency10.5
39hodgkin's lymphoma10.5
40hepatitis a10.5
41hepatitis c virus10.5
42autoimmune hepatitis10.5
43crohn's disease10.5
44diffuse large b-cell lymphoma10.5
45multiple myeloma10.5
46non-hodgkin lymphoma10.5
47splenic infarction10.5
48macroglobulinemia10.5
49cholangitis10.5
50myeloma10.5

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Symptoms for Autoimmune Hemolytic Anemia

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Clinical features from OMIM:

205700

HPO human phenotypes related to Autoimmune Hemolytic Anemia:

(show all 17)
id Description Frequency HPO Source Accession
1 pallor hallmark (90%) HP:0000980
2 muscle weakness hallmark (90%) HP:0001324
3 hemolytic anemia hallmark (90%) HP:0001878
4 migraine hallmark (90%) HP:0002076
5 respiratory insufficiency hallmark (90%) HP:0002093
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the liver typical (50%) HP:0001392
8 lymphoma typical (50%) HP:0002665
9 congestive heart failure occasional (7.5%) HP:0001635
10 splenomegaly occasional (7.5%) HP:0001744
11 abdominal pain occasional (7.5%) HP:0002027
12 abnormality of urine homeostasis occasional (7.5%) HP:0003110
13 abnormality of temperature regulation occasional (7.5%) HP:0004370
14 arrhythmia occasional (7.5%) HP:0011675
15 autosomal recessive inheritance HP:0000007
16 autoimmune hemolytic anemia HP:0001890
17 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Autoimmune Hemolytic Anemia

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Anatomical Context for Autoimmune Hemolytic Anemia

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MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

32
Testes, T cells, B cells, Liver, Bone marrow, Bone, Thyroid, Heart, Kidney, Brain, Pancreas, Myeloid, Nk cells, Neutrophil

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD55, CD59, CD40LG, HP, T
2MP:00053977.7CD55, CD59, CD40LG, HP, G6PD
3MP:00053767.1T, G6PD, HP, CD40LG, CD59, CD55
4MP:00107686.9T, G6PD, HP, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

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Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
2
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. (25096221)
2014
3
HBV and HCV Coinfection Associated with Warm-Type Autoimmune Hemolytic Anemia: A Case Report. (25330536)
2014
4
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
5
Autoimmune hemolytic anemia occurred in burn patient: A case report. (24045069)
2013
6
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
7
Megadose Methyl-Prednisolone (MDMP) for Autoimmune Hemolytic Anemia. (24385798)
2013
8
Rare coexistence of Rosai-Dorfman disease and nodal marginal zone lymphoma complicated by severe life-threatening autoimmune hemolytic anemia. (23270580)
2013
9
Autoimmune hemolytic anemia in a patient with Malaria. (24014948)
2013
10
A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child. (24046918)
2013
11
Megadose Methylprednisolone (MDMP) Treatment in a Patient with Autoimmune Hemolytic Anemia (AIHA) Resistant to Conventional Corticosteroid Administration: A Case Report. (24385786)
2013
12
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
13
B-cell receptor configuration and adverse cytogenetics are associated with autoimmune hemolytic anemia in chronic lymphocytic leukemia. (23115077)
2013
14
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
15
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
16
Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia. (22851939)
2012
17
IgA-induced autoimmune hemolytic anemia in a patient with antiphospholipid syndrome. (22988389)
2012
18
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
19
Autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia is associated with IgVH status. (20410184)
2010
20
Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. (20445515)
2010
21
Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study. (20625007)
2010
22
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
23
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
24
Primary Biliary Cirrhosis-Related Autoimmune Hemolytic Anemia: Three Case Reports and Review of the Literature. (21103282)
2009
25
Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. (19578637)
2009
26
Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly. (18452105)
2008
27
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
28
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
29
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
30
Living donor liver transplantion for primary biliary cirrhosis with autoimmune hemolytic anemia: a case report. (17415648)
2007
31
Cold agglutinin induced autoimmune hemolytic anemia and NK-cell leukemia: a new association. (17301976)
2007
32
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
33
Warm autoimmune hemolytic anemia is an IgM-IgG immune complex disease. (16242913)
2005
34
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
35
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
36
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
37
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
38
Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. (14563012)
2003
39
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
40
Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. (12483369)
2002
41
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
42
Autoimmune hemolytic anemia caused by IgG lambda-monotypic cold agglutinins of anti-Pr specificity after rubella infection. (11316899)
2001
43
Acute parvovirus B19 infection as a cause of autoimmune hemolytic anemia. (10980646)
2000
44
Open heart surgery in a patient with autoimmune hemolytic anemia. (10402776)
1999
45
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
46
High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia. (9267883)
1997
47
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
48
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
49
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
50
The role of anticardiolipin autoantibodies in the pathogenesis of autoimmune hemolytic anemia in systemic lupus erythematosus. (8014933)
1993

Variations for Autoimmune Hemolytic Anemia

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Expression for genes affiliated with Autoimmune Hemolytic Anemia

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Expression patterns in normal tissues for genes affiliated with Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

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Pathways related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, GYPA
2
Show member pathways
9.0CD55, CD59
3
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.0CD55, CD59
4
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.0CD59, CD55
58.6CD55, CD59, GYPA

Compounds for genes affiliated with Autoimmune Hemolytic Anemia

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Compounds related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1tuberculin4410.1CD40LG, HP
2thiobarbituric acid4410.0HP, G6PD
323-diphosphoglycerate4410.0G6PD, HP
4zinc protoporphyrin4410.0HP, G6PD
5sulfamethoxazole50 44 1111.9G6PD, CD40LG
6tocopherol449.9G6PD, HP
7starch449.9G6PD, HP
8cellulose acetate449.9HP, G6PD
9galalpha(1,3)gal449.9CD59, CD40LG
10glutaraldehyde449.8CD40LG, G6PD
11neopterin449.8CD40LG, HP
12hypoxanthine44 24 1111.7GYPA, G6PD
13sulfasalazine28 44 50 1112.6G6PD, HP, CD40LG
14ribavirin44 50 1111.6G6PD, CD40LG, HP
15lactose44 1110.6G6PD, CD40LG, HP
16vitamin b12449.6G6PD, HP, CD40LG
17polyethylene glycol449.6HP, CD40LG, G6PD
18malondialdehyde449.6HP, G6PD
19thyroxine44 2410.6CD40LG, G6PD, HP
20folate449.6G6PD, CD40LG, HP
21epinephrine44 24 1111.5CD40LG, HP, G6PD
22ascorbic acid44 2410.5G6PD, HP, CD40LG
23hirudin449.5CD40LG, CD55
24ganglioside449.4CD59, CD40LG
25fludarabine44 50 1111.4CD40LG, CD55
26fitc449.3CD59, CD55
27polysaccharide449.2CD40LG, HP, CD55
28anaphylatoxin449.1HP, CD55, CD59
29adenylate449.1G6PD, HP, CD40LG
30sucrose44 24 1111.0CD55, HP, CD59
31atorvastatin44 50 28 24 1113.0CD55, CD59, CD40LG
32glycolipid449.0CD59, CD55, GYPA
33aspirin44 50 28 2412.0CD59, HP, CD40LG, G6PD
34heparin44 28 24 1112.0HP, CD40LG, CD55
35lactate449.0CD40LG, HP, G6PD, CD59
36phospholipid449.0HP, CD59, CD55
37iron44 249.9CD59, CD55, HP
38cisplatin44 50 61 1111.9CD55, G6PD, CD40LG
39alanine448.8GYPA, CD40LG, HP, CD55
40actinomycin d448.8CD40LG, CD55, G6PD, HP
41creatinine448.8G6PD, HP, CD40LG, CD55
42aspartate448.8CD40LG, G6PD, HP, CD55
43rituximab44 50 1110.7CD40LG, HP, CD55, CD59
44estrogen448.7HP, CD55, G6PD, CD40LG
45cyclosporin a44 28 6110.7CD55, CD59, CD40LG, HP
46sialic acid448.7GYPA, CD59, HP, CD55
47atp44 289.5CD55, CD59, HP, G6PD
48glucose448.5CD55, HP, G6PD, CD59
49lipid448.1GYPA, HP, G6PD, CD59, CD55
50serine448.0CD40LG, HP, G6PD, CD55

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

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Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.1CD55, CD59, HP, G6PD

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.0CD55, CD59

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:0016189.2CD55, GYPA

Products for genes affiliated with Autoimmune Hemolytic Anemia

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Sources for Autoimmune Hemolytic Anemia

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3CDC
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14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet