MCID: ATM010
MIFTS: 57

Autoimmune Hemolytic Anemia malady

Genetic diseases, Rare diseases, Immune diseases, Blood diseases, Metabolic diseases categories

Aliases & Classifications for Autoimmune Hemolytic Anemia

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Autoimmune Hemolytic Anemia, Aliases & Descriptions:

Name: Autoimmune Hemolytic Anemia 9 41 11 43 60
Idiopathic Autoimmune Hemolytic Anemia 41 60
Immuno-Hemolytic Anemia 41 60
Familial Auto-Immune Hemolytic Anemia 41
Acquired Autoimmune Hemolytic Anemia 41
 
Autoimmune Hemolytic Anemia Nos 9
Autoimmune Haemolytic Anaemia 9
Anemia Hemolytic Autoimmune 41
Aiha 41
Aha 41


Classifications:



External Ids:

Disease Ontology9 DOID:718
MeSH33 D000744
NCIt38 C34378
ICD9CM27 283.0

Summaries for Autoimmune Hemolytic Anemia

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NIH Rare Diseases:41 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards based summary: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hemolytic anemia and thrombocytopenia, and has symptoms including pallor, muscle weakness and hemolytic anemia. An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Malaria and Creation of C4 and C2 activators. The drugs cyclophosphamide and immunoglobulins, intravenous and the compounds tuberculin and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include testes, b cells and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:9 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:63 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Related Diseases for Autoimmune Hemolytic Anemia

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Diseases in the Hemolytic Anemia family:

autoimmune hemolytic anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia31.8G6PD, HP, CD59, CD55
2thrombocytopenia31.4CD40LG, HP
3hepatitis c31.3HP, CD40LG
4chronic lymphocytic leukemia31.2CD59, CD55, CD40LG
5viral hepatitis31.2G6PD
6hereditary spherocytosis31.1GYPA, G6PD
7glucose-6-phosphate dehydrogenase deficiency30.9HP, G6PD
8leukemia30.8GYPA, CD55, CD59, CD40LG, HP
9systemic lupus erythematosus30.7CD40LG, CD59, CD55
10congenital hemolytic anemia30.7G6PD, HP
11nephritis30.7CD55, CD40LG
12malaria30.6HP, G6PD
13sickle cell disease30.6HP, G6PD
14glomerulonephritis30.6CD59, CD55, CD40LG
15pancytopenia30.5HP, CD55
16arthritis30.4CD55, CD59, HP
17myelodysplastic syndrome30.4GYPA, CD55, CD59
18lupus nephritis30.4CD55, CD40LG
19graves' disease30.2CD59, CD55
20hemoglobinuria30.0HP, G6PD, CD59, CD55
21pancreatic cancer29.9CD55, CD59, HP
22rheumatoid arthritis29.8CD55, HP, CD40LG, CD59
23paroxysmal nocturnal hemoglobinuria29.7CD59, HP, G6PD, CD55
24hepatitis11.0
25pure red-cell aplasia10.8
26mixed-type autoimmune hemolytic anemia10.7
27purpura10.7
28hodgkin lymphoma10.7
29lupus erythematosus10.6
30drug-induced autoimmune hemolytic anemia10.6
31hematopoietic stem cell transplantation10.6
32primary biliary cirrhosis10.6
33ulcerative colitis10.6
34evans' syndrome10.6
35antiphospholipid syndrome10.6
36colitis10.6
37warm antibody hemolytic anemia10.6
38hepatitis c virus10.5
39b-cell lymphomas10.5
40common variable immunodeficiency10.5
41crohn's disease10.5
42hepatitis a10.5
43multiple myeloma10.5
44autoimmune hepatitis10.5
45diffuse large b-cell lymphoma10.5
46thalassemia10.5
47splenic infarction10.5
48macroglobulinemia10.5
49cholangitis10.5
50myeloma10.5

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Symptoms for Autoimmune Hemolytic Anemia

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HPO human phenotypes related to Autoimmune Hemolytic Anemia:

(show all 17)
id Description Frequency HPO Source Accession
1 pallor hallmark (90%) HP:0000980
2 muscle weakness hallmark (90%) HP:0001324
3 hemolytic anemia hallmark (90%) HP:0001878
4 migraine hallmark (90%) HP:0002076
5 respiratory insufficiency hallmark (90%) HP:0002093
6 autoimmunity hallmark (90%) HP:0002960
7 abnormality of the liver typical (50%) HP:0001392
8 lymphoma typical (50%) HP:0002665
9 congestive heart failure occasional (7.5%) HP:0001635
10 splenomegaly occasional (7.5%) HP:0001744
11 abdominal pain occasional (7.5%) HP:0002027
12 abnormality of urine homeostasis occasional (7.5%) HP:0003110
13 abnormality of temperature regulation occasional (7.5%) HP:0004370
14 arrhythmia occasional (7.5%) HP:0011675
15 autosomal recessive inheritance HP:0000007
16 autoimmune hemolytic anemia HP:0001890
17 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Autoimmune Hemolytic Anemia

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Anatomical Context for Autoimmune Hemolytic Anemia

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MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

31
Testes, B cells, T cells, Liver, Heart, Bone marrow, Bone, Thyroid, Kidney, Brain, Colon, Pancreas, Breast, Myeloid, Monocytes, Nk cells, Neutrophil

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.7CD55, CD59, CD40LG, HP, T
2MP:00053977.7CD55, CD59, CD40LG, HP, G6PD
3MP:00053767.1T, G6PD, HP, CD40LG, CD59, CD55
4MP:00107686.9T, G6PD, HP, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

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Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
2
Coombs negative autoimmune hemolytic anemia in Crohn's disease. (25488633)
2014
3
Anti-erythropoietin receptor antibody-associated pure red cell aplasia accompanied by Coombs-negative autoimmune hemolytic anemia in a patient with T cell/histiocyte-rich large B cell lymphoma. (25096221)
2014
4
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
5
Autoimmune hemolytic anemia occurred in burn patient: A case report. (24045069)
2013
6
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
7
Megadose Methyl-Prednisolone (MDMP) for Autoimmune Hemolytic Anemia. (24385798)
2013
8
Rare coexistence of Rosai-Dorfman disease and nodal marginal zone lymphoma complicated by severe life-threatening autoimmune hemolytic anemia. (23270580)
2013
9
Autoimmune hemolytic anemia in a patient with Malaria. (24014948)
2013
10
A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child. (24046918)
2013
11
Megadose Methylprednisolone (MDMP) Treatment in a Patient with Autoimmune Hemolytic Anemia (AIHA) Resistant to Conventional Corticosteroid Administration: A Case Report. (24385786)
2013
12
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
13
B-cell receptor configuration and adverse cytogenetics are associated with autoimmune hemolytic anemia in chronic lymphocytic leukemia. (23115077)
2013
14
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
15
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
16
Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia. (22851939)
2012
17
IgA-induced autoimmune hemolytic anemia in a patient with antiphospholipid syndrome. (22988389)
2012
18
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
19
Autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia is associated with IgVH status. (20410184)
2010
20
Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. (20445515)
2010
21
Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study. (20625007)
2010
22
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
23
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
24
Primary Biliary Cirrhosis-Related Autoimmune Hemolytic Anemia: Three Case Reports and Review of the Literature. (21103282)
2009
25
Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia: case report and literature review. (19578637)
2009
26
Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly. (18452105)
2008
27
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
28
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
29
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
30
Living donor liver transplantion for primary biliary cirrhosis with autoimmune hemolytic anemia: a case report. (17415648)
2007
31
Cold agglutinin induced autoimmune hemolytic anemia and NK-cell leukemia: a new association. (17301976)
2007
32
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
33
Warm autoimmune hemolytic anemia is an IgM-IgG immune complex disease. (16242913)
2005
34
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
35
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
36
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
37
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
38
Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. (14563012)
2003
39
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
40
Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. (12483369)
2002
41
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
42
Autoimmune hemolytic anemia caused by IgG lambda-monotypic cold agglutinins of anti-Pr specificity after rubella infection. (11316899)
2001
43
Acute parvovirus B19 infection as a cause of autoimmune hemolytic anemia. (10980646)
2000
44
Open heart surgery in a patient with autoimmune hemolytic anemia. (10402776)
1999
45
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
46
High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia. (9267883)
1997
47
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
48
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
49
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
50
The role of anticardiolipin autoantibodies in the pathogenesis of autoimmune hemolytic anemia in systemic lupus erythematosus. (8014933)
1993

Variations for Autoimmune Hemolytic Anemia

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Expression for genes affiliated with Autoimmune Hemolytic Anemia

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Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

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Pathways related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CD40LG, GYPA
2
Show member pathways
9.0CD55, CD59
3
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.0CD55, CD59
4
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.0CD55, CD59
58.6GYPA, CD55, CD59

Compounds for genes affiliated with Autoimmune Hemolytic Anemia

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Compounds related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1tuberculin4310.1CD40LG, HP
223-diphosphoglycerate4310.0G6PD, HP
3thiobarbituric acid4310.0G6PD, HP
4zinc protoporphyrin4310.0G6PD, HP
5sulfamethoxazole49 43 1211.9CD40LG, G6PD
6tocopherol439.9HP, G6PD
7starch439.9HP, G6PD
8cellulose acetate439.9HP, G6PD
9galalpha(1,3)gal439.9CD40LG, CD59
10glutaraldehyde439.8CD40LG, G6PD
11hypoxanthine43 24 1211.7GYPA, G6PD
12neopterin439.7CD40LG, HP
13malondialdehyde439.6HP, G6PD
14sulfasalazine28 43 49 1212.6CD40LG, HP, G6PD
15lactose43 1210.6CD40LG, HP, G6PD
16ribavirin43 49 1211.6CD40LG, HP, G6PD
17vitamin b12439.6G6PD, HP, CD40LG
18polyethylene glycol439.6CD40LG, HP, G6PD
19thyroxine43 2410.6CD40LG, HP, G6PD
20folate439.6CD40LG, HP, G6PD
21epinephrine43 24 1211.5G6PD, HP, CD40LG
22ascorbic acid43 2410.5CD40LG, HP, G6PD
23hirudin439.5CD40LG, CD55
24ganglioside439.4CD59, CD40LG
25fludarabine43 49 1211.4CD55, CD40LG
26fitc439.3CD55, CD59
27polysaccharide439.2CD55, CD40LG, HP
28anaphylatoxin439.1CD55, CD59, HP
29adenylate439.1G6PD, HP, CD40LG
30sucrose43 24 1211.0HP, CD59, CD55
31atorvastatin43 49 28 24 1213.0CD55, CD59, CD40LG
32glycolipid439.0GYPA, CD59, CD55
33aspirin43 49 28 2412.0G6PD, HP, CD40LG, CD59
34heparin43 28 24 1212.0CD55, CD40LG, HP
35lactate439.0G6PD, HP, CD40LG, CD59
36phospholipid439.0HP, CD59, CD55
37iron43 249.9CD55, CD59, HP
38cisplatin43 49 59 1211.9G6PD, CD40LG, CD55
39alanine438.8CD55, CD40LG, HP, GYPA
40actinomycin d438.8CD55, CD40LG, HP, G6PD
41creatinine438.8G6PD, HP, CD40LG, CD55
42aspartate438.8G6PD, HP, CD40LG, CD55
43rituximab43 49 1210.7CD55, CD59, CD40LG, HP
44estrogen438.7G6PD, HP, CD40LG, CD55
45cyclosporin a43 28 5910.7HP, CD40LG, CD59, CD55
46sialic acid438.7GYPA, HP, CD59, CD55
47atp43 289.5G6PD, HP, CD59, CD55
48glucose438.5G6PD, HP, CD59, CD55
49lipid438.1CD55, CD59, HP, GYPA, G6PD
50serine438.0CD55, CD40LG, HP, G6PD

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

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Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700628.1CD55, CD59, HP, G6PD

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:00304499.0CD55, CD59

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.2CD55, GYPA

Products for genes affiliated with Autoimmune Hemolytic Anemia

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Sources for Autoimmune Hemolytic Anemia

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
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46OMIM via Orphanet
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51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet