MCID: ATM010
MIFTS: 61

Autoimmune Hemolytic Anemia malady

Categories: Rare diseases, Immune diseases, Genetic diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Autoimmune Hemolytic Anemia

Aliases & Descriptions for Autoimmune Hemolytic Anemia:

Name: Autoimmune Hemolytic Anemia 12 50 52 14 69
Idiopathic Autoimmune Hemolytic Anemia 50 69
Anemia Hemolytic Autoimmune 50 29
Immuno-Hemolytic Anemia 50 69
Familial Auto-Immune Hemolytic Anemia 50
Acquired Autoimmune Hemolytic Anemia 50
Autoimmune Hemolytic Anemia Nos 12
Autoimmune Haemolytic Anaemia 12
Anemia, Hemolytic, Autoimmune 42

Characteristics:

HPO:

32
autoimmune hemolytic anemia:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:718
ICD9CM 35 283.0
MeSH 42 D000744
NCIt 47 C34378
UMLS 69 C0002880

Summaries for Autoimmune Hemolytic Anemia

NIH Rare Diseases : 50 autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 3/9/2016

MalaCards based summary : Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to tuberculosis and myeloid leukemia, and has symptoms including fatigue, dyspnea and fever. An important gene associated with Autoimmune Hemolytic Anemia is CD59 (CD59 Molecule (CD59 Blood Group)), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, b cells and t cells, and related phenotypes are hematopoietic system and cardiovascular system

Disease Ontology : 12 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia : 71 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Related Diseases for Autoimmune Hemolytic Anemia

Diseases in the Hemolytic Anemia family:

Congenital Hemolytic Anemia Autoimmune Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 29.8 CD40LG IL10 IL2 IL4
2 myeloid leukemia 29.6 APOH CD40LG
3 drug-induced autoimmune hemolytic anemia 12.4
4 mixed-type autoimmune hemolytic anemia 12.1
5 autoimmune hemolytic anemia, warm type 12.1
6 neonatal autoimmune hemolytic anemia 12.0
7 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 12.0
8 warm antibody hemolytic anemia 11.8
9 evans' syndrome 11.5
10 cold agglutinin disease 11.4
11 hemolytic anemia 11.1
12 immunodeficiency, common variable, 8, with autoimmunity 11.1
13 lymphoproliferative syndrome 1 10.9
14 autoimmune lymphoproliferative syndrome 10.9
15 immunodeficiency 10 10.9
16 ras-associated autoimmune leukoproliferative disorder 10.9
17 immunodeficiency due to purine nucleoside phosphorylase deficiency 10.9
18 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.9
19 autoimmune lymphoproliferative syndrome, type ii 10.9
20 idiopathic cd4-positive t-lymphocytopenia 10.9
21 leukemia 10.6
22 hepatitis 10.5
23 lymphoma 10.5
24 chronic lymphocytic leukemia 10.5
25 thrombocytopenia 10.3
26 pure red-cell aplasia 10.3
27 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 IL4
28 sarcoma 10.3 IL2 IL4
29 asymptomatic neurosyphilis 10.3 IL10 IL4
30 vulvar vestibulitis syndrome 10.3 IL2 IL4
31 lagophthalmos 10.3 IL10 IL4
32 ceroid lipofuscinosis, neuronal, 3 10.3 IL10 IL4
33 autosomal dominant deafness-onychodystrophy syndrome 10.3 IL2 IL4
34 conidiobolomycosis 10.3 IL10 IL4
35 mental retardation, x-linked, snyder-robinson type 10.3 CD55 CD59
36 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL10 IL2
37 purpura 10.2
38 tungiasis 10.2 IL10 IL4
39 muscular dystrophy limb girdle type 2a, erb type 10.2 CD55 CD59
40 hematopoietic stem cell transplantation 10.2
41 hepatitis c 10.2
42 acute myeloid leukemia with recurrent genetic anomaly 10.2 IL10 IL2 IL4
43 abnormal retinal correspondence 10.2 IL10 IL2 IL4
44 orbital osteomyelitis 10.2 IL10 IL2 IL4
45 periventricular heterotopia with microcephaly 10.2 CD55 CD59
46 hendra virus infection 10.2 APOH F3
47 dengue hemorrhagic fever 10.2 IL10 IL2 IL4
48 liver inflammatory pseudotumor 10.2 IL10 IL2 IL4
49 blue toe syndrome 10.2 IL10 IL2 IL4
50 systemic lupus erythematosus 10.2

Comorbidity relations with Autoimmune Hemolytic Anemia via Phenotypic Disease Network (PDN):


Acquired Thrombocytopenia Acute Cystitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Leukemia, B-Cell, Chronic
Neutropenia

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to Autoimmune Hemolytic Anemia

Symptoms & Phenotypes for Autoimmune Hemolytic Anemia

Human phenotypes related to Autoimmune Hemolytic Anemia:

32 (show all 18)
id Description HPO Frequency HPO Source Accession
1 fatigue 32 HP:0012378
2 dyspnea 32 HP:0002094
3 fever 32 HP:0001945
4 headache 32 HP:0002315
5 abdominal pain 32 HP:0002027
6 muscle weakness 32 HP:0001324
7 splenomegaly 32 HP:0001744
8 abnormality of metabolism/homeostasis 32 HP:0001939
9 arrhythmia 32 HP:0011675
10 immunodeficiency 32 HP:0002721
11 hemolytic anemia 32 HP:0001878
12 pallor 32 HP:0000980
13 congestive heart failure 32 HP:0001635
14 autoimmunity 32 HP:0002960
15 lymphoma 32 HP:0002665
16 abnormality of leukocytes 32 HP:0001881
17 abnormal urinary color 32 HP:0012086
18 autoimmune hemolytic anemia 32 HP:0001890

MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 IL10 IL2 IL4 SIRPA STIM1 CD40LG
2 cardiovascular system MP:0005385 9.86 SERPING1 SIRPA STIM1 CD40LG F3 HP
3 homeostasis/metabolism MP:0005376 9.65 APOH CD40LG CD59 F3 HP IL10
4 immune system MP:0005387 9.28 CD40LG CD5 F3 HP IL10 IL2

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

Drugs for Autoimmune Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
5
alemtuzumab Approved, Investigational Phase 2, Phase 3 216503-57-0
6
Fludarabine Approved Phase 3,Phase 2 21679-14-1, 75607-67-9 30751
7
Vidarabine Approved Phase 3,Phase 2 24356-66-9 32326 21704
8
Chlorambucil Approved Phase 3 305-03-3 2708
9 Antibodies Phase 3,Phase 2
10 Antiemetics Phase 3,Phase 2
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 Antineoplastic Agents, Hormonal Phase 3,Phase 2
13 Antirheumatic Agents Phase 3,Phase 2
14 Autonomic Agents Phase 3,Phase 2
15 Gastrointestinal Agents Phase 3,Phase 2
16 glucocorticoids Phase 3,Phase 2
17 Hormone Antagonists Phase 3,Phase 2
18 Hormones Phase 3,Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
20 Immunoglobulins Phase 3,Phase 2
21 Methylprednisolone acetate Phase 3,Phase 2
22 Methylprednisolone Hemisuccinate Phase 3,Phase 2
23 Neuroprotective Agents Phase 3,Phase 2
24 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
25 Prednisolone acetate Phase 3,Phase 2
26 Prednisolone hemisuccinate Phase 3,Phase 2
27 Prednisolone phosphate Phase 3,Phase 2
28 Protective Agents Phase 3,Phase 2
29 Alkylating Agents Phase 3,Phase 2
30 Anti-Infective Agents Phase 3,Phase 2,Phase 1
31 Antineoplastic Agents, Alkylating Phase 3,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Antibodies, Monoclonal Phase 3,Phase 2
34 Antimetabolites Phase 3,Phase 2
35 Antimetabolites, Antineoplastic Phase 3,Phase 2
36 Antiviral Agents Phase 3,Phase 2,Phase 1
37
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
38
Lenograstim Approved Phase 2 135968-09-1
39
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
40
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
41
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
42
Mechlorethamine Approved Phase 2 51-75-2 4033
43
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
44
Acetaminophen Approved Phase 2 103-90-2 1983
45
Diphenhydramine Approved Phase 2 58-73-1, 147-24-0 3100
46
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
47
Hydroxyurea Approved Phase 2 127-07-1 3657
48
Melphalan Approved Phase 2 148-82-3 4053 460612
49
Promethazine Approved Phase 2 60-87-7 4927
50
Thiotepa Approved Phase 2 52-24-4 5453

Interventional clinical trials:

(show all 34)
id Name Status NCT ID Phase
1 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3
2 Alemtuzumab and Rituximab in the Treatment of Refractory Autoimmune Cytopenias Completed NCT00749112 Phase 2, Phase 3
3 Rituximab in Auto-Immune Hemolytic Anemia Active, not recruiting NCT01181154 Phase 3
4 Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia Active, not recruiting NCT00824265 Phase 3
5 Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia Active, not recruiting NCT00748189 Phase 3
6 Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy Active, not recruiting NCT01039376 Phase 3
7 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2
8 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2
9 Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2
10 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2
11 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2
12 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2
13 Therapy of Chronic Cold Agglutinin Disease With Eculizumab Completed NCT01303952 Phase 2
14 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2
15 A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) Recruiting NCT02612558 Phase 2
16 Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Recruiting NCT02389231 Phase 1, Phase 2
17 Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT Recruiting NCT01962415 Phase 2
18 Short Course of Bortezomib in Anemic Patients With Refractory Cold Agglutinin Disease Active, not recruiting NCT01696474 Phase 2
19 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2
20 The Efficacy and Safety of Alemtuzumab in Auotoimmune Cytopenias Terminated NCT00472433 Phase 2
21 Treatment of Autoimmune Thrombocytopenia (AITP) Completed NCT00001630 Phase 1
22 Safety, Tolerability and Activity of TNT009 in Healthy Volunteers and Patients With Complement Mediated Disorders Recruiting NCT02502903 Phase 1
23 A Safety Study of SYNT001 in Subjects With Chronic, Stable Warm Autoimmune Hemolytic Anemia (WAIHA) Not yet recruiting NCT03075878 Phase 1
24 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055
25 Auto-antibodies Prevalence and CD1 Role in Gaucher Disease Completed NCT02650219
26 The RITAI Cohort: An Observational Study on Rituximab Off-label Use for Auto-immune Disorders Completed NCT00960713
27 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
28 Immunoglobulin Dosage and Administration Form in CIDP and MMN Completed NCT02111590
29 Study the Role of T Lymphocytes in Autoimmune Hemolytic Anemia Recruiting NCT02828670
30 Immunopathology of Autoimmune Hemolytic Anemia Recruiting NCT02158195
31 Microvascular and Fibrosis Imaging Study Recruiting NCT01758250
32 Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders Recruiting NCT01758042
33 Study of an Intervention to Improve Problem List Accuracy and Use Active, not recruiting NCT01105923
34 Single Incision Versus Standard Laparoscopic Splenectomy Withdrawn NCT01276561

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: anemia, hemolytic, autoimmune

Genetic Tests for Autoimmune Hemolytic Anemia

Genetic tests related to Autoimmune Hemolytic Anemia:

id Genetic test Affiliating Genes
1 Autoimmune Hemolytic Anemia 29

Anatomical Context for Autoimmune Hemolytic Anemia

MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

39
Testes, B Cells, T Cells, Liver, Heart, Bone, Bone Marrow

Publications for Autoimmune Hemolytic Anemia

Articles related to Autoimmune Hemolytic Anemia:

(show top 50) (show all 635)
id Title Authors Year
1
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
2
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
3
Simultaneous occurrence of autoimmune hemolytic anemia and pure red cell aplasia. ( 28090019 )
2016
4
IgG4-related Lung Disease Associated with Autoimmune Hemolytic Anemia: A Case Report and a Literature Review. ( 27580552 )
2016
5
"Clinical characteristics and outcome of patients with autoimmune hemolytic anemia (AIHA) uniformly defined as primary by a diagnostic work-up". ( 27059006 )
2016
6
Autoimmune Hemolytic Anemia as a Complication of Nivolumab Therapy. ( 27920704 )
2016
7
Risk factor analysis of autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation in children. ( 27861376 )
2016
8
Autoimmune Hemolytic Anemia Induced by Adalimumab. ( 26984100 )
2016
9
Burkitt Lymphoma Preceded by Autoimmune Hemolytic Anemia due to Anti-D Antibody. ( 27523004 )
2016
10
Bilateral Prefoveal Sub-Internal Limiting Membrane Hemorrhage in Autoimmune Hemolytic Anemia. ( 27977840 )
2016
11
Life-Threatening Autoimmune Hemolytic Anemia and Idhiopatic Thrombocytopenic Purpura. Successful Selective Splenic Artery Embolization. ( 27158433 )
2016
12
Giant cell hepatitis with autoimmune hemolytic anemia in a Korean infant. ( 26841192 )
2016
13
Identification of Stages of Erythroid Differentiation in Bone Marrow and Erythrocyte Subpopulations in Blood Circulation that Are Preferentially Lost in Autoimmune Hemolytic Anemia in Mouse. ( 27870894 )
2016
14
Pure Red Cell Aplasia and Autoimmune Hemolytic Anemia Sequentially Occurring in a Patient with Large Granular T-lymphocytic Leukemia. ( 27250059 )
2016
15
Diagnosis and treatment of autoimmune hemolytic anemia: classic approach and recent advances. ( 27382547 )
2016
16
Autoimmune hemolytic anemia in systemic lupus erythematosus at diagnosis: differences between pediatric and adult patients. ( 27821514 )
2016
17
Autoimmune Hemolytic Anemia in Individuals Aged 75 and Older: A Study of 10 Individuals. ( 27321629 )
2016
18
Autoimmune hemolytic anemia (AIHA) associated with chronic lymphocytic leukemia in the current era of targeted therapy. ( 27657651 )
2016
19
Cold autoimmune hemolytic anemia secondary to atypical pneumonia. ( 27597386 )
2016
20
Autoimmune Hemolytic Anemia Triggered by Infection with Human Parvovirus B19 after Total Abdominal Colectomy for Ulcerative Colitis. ( 26984090 )
2016
21
Autoimmune Hemolytic Anemia and Hodgkin's Disease: An Unusual Pediatric Association. ( 26904342 )
2016
22
Fatal warm autoimmune hemolytic anemia in a child due to IgM-type autoantibodies. ( 27273179 )
2016
23
Autoimmune Hemolytic Anemia in Children: Mayo Clinic Experience. ( 26925716 )
2016
24
Systemic lupus erythematosus presenting with mixed-type fulminant autoimmune hemolytic anemia. ( 26892457 )
2016
25
Response to ibrutinib of refractory life-threatening autoimmune hemolytic anemia occurring in a relapsed chronic lymphocytic leukemia patient with 17p deletion. ( 26999572 )
2016
26
Significant methemoglobinemia with bovine hemoglobin infusion in a case with severe autoimmune hemolytic anemia. ( 26954456 )
2016
27
Fulminant visceral disseminated varicella-zoster virus infection without skin involvement in a patient with autoimmune hemolytic anemia on prednisolone therapy. ( 27169452 )
2016
28
Management of refractory autoimmune hemolytic anemia via allogeneic stem cell transplantation. ( 27272445 )
2016
29
No evidence of splenic disease in patients with splenic marginal zone lymphoma undergoing splenectomy for autoimmune hemolytic anemia after monotherapy with rituximab. ( 27082039 )
2016
30
Blood Group Discrepancy-First Sign of Autoimmune Hemolytic Anemia after Hematopoietic Stem Cell Transplantation in a Child. ( 27408394 )
2016
31
A monocentric retrospective study comparing pulse cyclophosphamide therapy versus low dose rituximab in the treatment of refractory autoimmune hemolytic anemia in adults. ( 27376943 )
2016
32
Autoanti-C in a patient with primary sclerosing cholangitis and autoimmune hemolytic anemia: a rare presentation. ( 27834483 )
2016
33
Expression of activated molecules on CD5(+)B lymphocytes in autoimmune hemolytic anemia. ( 26968550 )
2016
34
Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells. ( 28028749 )
2016
35
Coombs-negative Autoimmune Hemolytic Anemia Followed by Anti-erythropoetin Receptor Antibody-associated Pure Red Cell Aplasia: A Case Report and Review of Literature. ( 26935373 )
2016
36
Blastic plasmacytoid dendritic cell neoplasm accompanied by autoimmune hemolytic anemia achieving complete remission with hydroxyurea and steroids. ( 26936199 )
2016
37
Autoimmune Hemolytic Anemia Induced by Adalimumab. ( 26984099 )
2016
38
Refractory IgG Warm Autoimmune Hemolytic Anemia Treated with Eculizumab: A Novel Application of Anticomplement Therapy. ( 27092282 )
2016
39
Difficult to swallow: warm autoimmune hemolytic anemia in a Jehovah's Witness treated with hemoglobin concentrate complicated by achalasia. ( 27062564 )
2016
40
Warm antibody autoimmune hemolytic anemia. ( 27913548 )
2016
41
Warm Autoimmune Hemolytic Anemia and Direct Antiglobulin Testing With a False-Negative Result in a 53-Year-Old Man: The DAT Will Set You Free. ( 27287943 )
2016
42
Clinical characteristics and treatment outcomes of primary autoimmune hemolytic anemia: a single center study from South India. ( 27382552 )
2016
43
AOHE: manuscript AOHE-D-16-00564 paroxysmal nocturnal hemoglobinuria with autoimmune hemolytic anemia following eculizumab therapy-with large granular lymphocytic leukemia. ( 27449072 )
2016
44
Pernicious Anemia with Autoimmune Hemolytic Anemia: A Case Report and Literature Review. ( 27559485 )
2016
45
Postoperative Recurrence of Invasive Thymoma with Cold Agglutinin Disease and Autoimmune Hemolytic Anemia. ( 27629968 )
2016
46
Neutrophil Erythrocyte Rosettes: An Unusual Manifestation of Autoimmune Hemolytic Anemia. ( 27408421 )
2016
47
Autoimmune hemolytic anemia after nivolumab treatment in Hodgkin lymphoma responsive to immunosuppressive treatment. A case report. ( 27539158 )
2016
48
Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia. ( 27077773 )
2016
49
An Unusual Presentation of Metastatic Breast Carcinoma as Cold Autoimmune Hemolytic Anemia. ( 25805683 )
2015
50
Fatal autoimmune hemolytic anemia due to immunoglobulin g autoantibody exacerbated by epstein-barr virus. ( 25617394 )
2015

Variations for Autoimmune Hemolytic Anemia

Expression for Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for Autoimmune Hemolytic Anemia

Pathways related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 CD40LG CD55 CD59 HP IL10 IL2
2
Show member pathways
13.13 APOH F3 IL2 SERPING1 SIRPA STIM1
3
Show member pathways
12.65 CD40LG CD55 IL10 IL2 IL4
4
Show member pathways
12.47 CD40LG IL10 IL2 IL4
5
Show member pathways
12.27 CD40LG IL10 IL2 IL4
6 12.15 CD40LG IL10 IL2 IL4 SIRPA
7
Show member pathways
11.98 IL10 IL2 IL4
8
Show member pathways
11.91 CD55 CD59 SERPING1
9 11.85 CD55 CD59 F3 SERPING1
10
Show member pathways
11.79 CD55 CD59 SERPING1
11 11.65 IL10 IL2 IL4
12
Show member pathways
11.6 CD40LG IL2 IL4
13 11.59 IL10 IL2 SIRPA
14 11.55 CD40LG IL10 IL4
15 11.47 CD40LG IL10 IL4
16 11.38 CD40LG CD5 IL10
17 11.28 IL10 IL2 IL4
18 11.24 CD5 CD55 CD59 IL4
19 11.09 CD5 CD59 IL10 IL2 IL4
20 11.06 CD40LG IL2 IL4
21 10.99 CD40LG IL10 IL2 IL4
22 10.97 IL10 IL2 IL4
23 10.75 IL10 IL2 IL4

GO Terms for Autoimmune Hemolytic Anemia

Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 APOH CD40LG CD55 CD59 F3 HP
2 cell surface GO:0009986 9.55 APOH CD40LG CD55 CD59 F3
3 extracellular space GO:0005615 9.28 APOH CD40LG CD59 F3 HP IL10

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 CD40LG CD59 IL10 IL2 IL4
2 regulation of complement activation GO:0030449 9.65 CD55 CD59 SERPING1
3 positive regulation of activated T cell proliferation GO:0042104 9.56 IL2 IL4
4 positive regulation of interleukin-10 production GO:0032733 9.55 CD40LG IL4
5 defense response to protozoan GO:0042832 9.54 IL10 IL4
6 B cell differentiation GO:0030183 9.54 CD40LG IL10 IL4
7 positive regulation of T cell differentiation GO:0045582 9.52 IL2 IL4
8 blood coagulation, intrinsic pathway GO:0007597 9.51 APOH SERPING1
9 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.49 IL2 IL4
10 negative regulation of nitric oxide biosynthetic process GO:0045019 9.46 IL10 IL4
11 positive regulation of isotype switching to IgG isotypes GO:0048304 9.43 IL2 IL4
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.4 IL10 IL4
13 type 2 immune response GO:0042092 9.26 IL10 IL4
14 regulation of isotype switching GO:0045191 9.16 IL10 IL4
15 negative regulation of T-helper 17 cell differentiation GO:2000320 8.96 IL2 IL4
16 positive regulation of T cell proliferation GO:0042102 8.92 CD40LG CD59 IL2 IL4

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 IL10 IL2 IL4
2 cytokine activity GO:0005125 8.92 CD40LG IL10 IL2 IL4

Sources for Autoimmune Hemolytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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