Autoimmune Hemolytic Anemia malady

NIH Rare Diseases: Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions.³⁰

MalaCards: Autoimmune Hemolytic Anemia, also known as familial auto-immune hemolytic anemia (subtype), is related to hemolytic anemia and hepatitis. An important gene associated with Autoimmune Hemolytic Anemia is CD59 (CD59 molecule, complement regulatory protein), and among its related pathways are RIG-I-like receptor signaling pathway and OX40 Pathway. The drugs cyclophosphamide and globulin,immune (iv) and the compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, monocytes and t cells, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Disease Ontology: An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.⁶

Wikipedia: Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed...⁴⁴ more...

Aliases & Descriptions:

autoimmune hemolytic anemia 6 30 8 32 43 familial auto-immune hemolytic anemia (subtype) 30 autoimmune hemolytic anemia nos (disorder) 6 idiopathic autoimmune hemolytic anemia 30 autoimmune hemolytic anemia (disorder) 6 acquired autoimmune hemolytic anemia 30

autoimmune haemolytic anaemias 6 autoimmune haemolytic anaemia 6 autoimmune hemolytic anemias 6 anemia hemolytic autoimmune 30 immuno-hemolytic anemia 30

Diseases related to autoimmune hemolytic anemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 732)

id	Related Disease	Score	Top Affiliating Genes
1	hemolytic anemia	35.3	PIGA, VWF, CD59, CD47, CD55, APOH
2	hepatitis	32.2	IFNA1, IFNA2, IFNB1, CR1
3	chronic lymphocytic leukemia	31.4	CD59, CD40LG, CD52, CD55, IL2, IL2RA
4	acquired von willebrand syndrome	30.3	VWF, CD40LG, F3
5	spherocytosis	30.2	CD47, GYPA, F5, HP, RHD, G6PD
6	pure red-cell aplasia	29.6	CD79A, CD40LG, IL2, IL2RA, IFNA1, HP
7	non-hodgkin lymphoma	29.2	MYC, CD59, CD52, CD55, IL2, IL2RA
8	crescentic glomerulonephritis	29.0	MPO, CD79A, IL2RA, F3, TNF, DST
9	angioedema	28.5	SERPING1, IL2, IL5, IGHE, IFNA2, F5
10	antiphospholipid syndrome	27.9	VWF, CD79A, CD40LG, APOH, IGHE, F5
11	diffuse large b-cell lymphoma	27.8	MYC, CD79A, CD40LG, IL10, IL2, IL2RA
12	crohn's disease	27.8	T, MPO, IL10, IL17A, IL4, IFNG
13	renal cell carcinoma	27.4	LAG3, CD59, IL2, IL2RA, IL4, IFNA1
14	churg-strauss syndrome	26.9	MPO, IL10, IL2, IL2RA, IL4, IL5
15	b-cell lymphomas	26.6	MYC, MPO, CD79A, CD59, CD40LG, CD55
16	pemphigus	25.5	CD79A, CD40LG, IL10, IL2, IL4, IL5
17	hepatitis a	25.1	CD79A, CD40LG, GYPA, IL10, IL2, IL2RA
18	systemic lupus erythematosus	24.7	VWF, MPO, CD79A, CD59, CD40LG, CD55
19	lymphocytic leukemia	24.7	MYC, LAG3, MPO, CD79A, CD59, CD40LG
20	anemia	24.0	PIGA, VWF, SERPING1, MYC, LAG3, T
21	thrombocytopenia	23.8	PIGA, VWF, CD79A, CD40LG, CD47, IL10
22	glomerulonephritis	21.8	VWF, SERPING1, MPO, CD79A, CD59, CD40LG
23	lupus erythematosus	21.7	VWF, SERPING1, MYC, MPO, CD79A, CD59
24	purpura	21.6	VWF, MPO, CD79A, CD40LG, IL10, IL17A
25	hodgkin's lymphoma	21.6	SERPING1, MYC, LAG3, MPO, CD79A, CD59
26	leukemia	20.0	PIGA, VWF, SERPING1, MYC, LAG3, T
27	carcinoma	18.5	VWF, SERPING1, MYC, LAG3, T, MPO
28	anhaptoglobinemia	13.7	HP, HPR
29	congenital dyserythropoietic anemia	13.7	CD55, RHD, SLC4A1
30	fetal erythroblastosis	13.7	CD55, RHCE, RHD, G6PD
31	hereditary elliptocytosis	13.7	RHD, G6PD, SLC4A1
32	transverse myelitis	13.7	CD40LG, IL17A, APOH
33	heme oxygenase-1 deficiency	13.6	HP, HMOX1
34	elliptocytosis	13.6	HP, RHD, G6PD, SLC4A1
35	neonatal jaundice	13.6	HMOX1, RHD, G6PD
36	dyserythropoietic anemia with thrombocytopenia	13.6	PIGA, CD59, CD55, IFNA1
37	congenital toxoplasmosis	13.6	CD79A, CD40LG
38	bilirubin metabolic disorder	13.5	HP, HMOX1, G6PD
39	hereditary spherocytosis	13.5	CD47, GYPA, RHD, G6PD, SLC4A1
40	fournier gangrene	13.5	CD40LG, IGHE, F3
41	typhus	13.5	CD40LG, IL17A, F3, G6PD
42	myelitis	13.5	CD40LG, IL17A, APOH, IFNB1
43	kernicterus	13.5	RHCE, RHD, G6PD
44	granulomatous hepatitis	13.5	IFNA1, IFNA2
45	bullous skin disease	13.5	IL5, DSG1, DST
46	acquired angioedema	13.5	SERPING1, F5, C1S
47	immunodeficiency with hyper igm	13.4	CD79A, CD40LG, IGHE
48	herpes gestationis	13.4	CD79A, DSG1, DST
49	mondor disease	13.4	APOH, F5
50	cd40 ligand deficiency	13.4	CD79A, CD40LG, IGHE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclophosphamide, globulin,immune (iv)

MalaCards organs/tissues related to autoimmune hemolytic anemia:

²²

MGI Mouse Phenotypes related to autoimmune hemolytic anemia:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.2	CD55, DST, SLC4A1
2	liver/biliary system phenotype	MP:0005370	9.5	SIRPA, IFNG, IL2
3	skeleton phenotype	MP:0005390	9.3	STIM1, IFNB1, IL17A, CD47, MYC, PIGA
4	hematopoietic system phenotype	MP:0005397	9.2	PIGA, SIRPA, STIM1, DST, RHD, IGHE
5	no phenotypic analysis	MP:0003012	9.1	DST, IFNB1, IL17A, CD79A, T, MYC
6	digestive/alimentary phenotype	MP:0005381	8.8	DST, IFNG, IL17A, T, MYC, VWF
7	reproductive system phenotype	MP:0005389	8.0	TNF, IFNG, IL4, IL10, CD59, PIGA
8	growth/size phenotype	MP:0005378	7.9	F3, DST, STIM1, SLC4A1, SIRPA, IL5
9	integument phenotype	MP:0010771	7.7	F3, DST, STIM1, SLC4A1, F5, IFNG
10	immune system phenotype	MP:0005387	7.5	TNF, STIM1, SLC4A1, SIRPA, IFNG, IFNB1
11	muscle phenotype	MP:0005369	7.5	SLC4A1, DST, TNF, HMOX1, F3, IL10
12	tumorigenesis	MP:0002006	6.9	TNF, HP, F3, IFNG, IFNB1, IL5
13	mortality/aging	MP:0010768	6.9	F3, HP, HMOX1, ODC1, G6PD, DST
14	homeostasis/metabolism phenotype	MP:0005376	6.2	IFNB1, F5, F3, HP, HMOX1, RHD
15	cardiovascular system phenotype	MP:0005385	5.6	F3, HP, HMOX1, TNF, G6PD, STIM1
16	behavior/neurological phenotype	MP:0005386	5.3	F5, F3, HMOX1, TNF, DST, SIRPA
17	cellular phenotype	MP:0005384	5.0	IFNB1, IFNG, F3, HP, HMOX1, TNF

Articles related to autoimmune hemolytic anemia:

(show all 40)

id	Title	Authors	Year	Affiliating Genes
1	Naturally occurring regulatory T cells and interleuki ns 10 and 12 in the pathogenesis of idiopathic warm autoimmune hemolytic anemia . (21721376)	Ahmad E.... Ibrahim H.	2011	IL10
2	Change and significance of Th17 cells and its secret ive IL-17 in patients with autoimmune hemolytic anemia]. (21651870)	He H.S.... Xie Y.H.	2011	IL17A
3	Autoimmune hemolytic anemia as a paraneoplastic pheno menon in solid tumors: A critical analysis of 52 cases reported in the literatu re. (20503022)	Puthenparambil J.... Kornek G.	2010	C1S
4	Severe autoimmune hemolytic anemia associated with Ig M warm auto-antibodies in primary SjAPgren's syndrome. (20374393)	Shinoda K.... Tobe K.	2010	CD40LG
5	Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia. (18954403)	Barros M.M.... Bordin J.O.	2009	CR1, CD55, CD59
6	Serologic findings in autoimmune hemolytic anemia associated with immunoglobulin M warm autoantibodies. (18980619)	Arndt P.A.... Garratty G.	2009	CD40LG
7	Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia. (17761830)	Ward F.J.... Barker R.N.	2008	T, LAG3
8	Autoimmune hemolytic anemia. (18537006)	Gupta V.... Bhatia B.D.	2008	G6PD
9	Membrane autoantibodies in systemic lupus erythematosus: a case of autoimmune hemolytic anemia, antiphospholipid antibodies, and transient acquired activated protein C resistance. (18673345)	Staropoli J.F.... Makar R.S.	2008	F3, F5
10	Etiology of hemolysis in two patients with hepatitis A infection: glucose-6-phosphate dehydrogenase deficiency or autoimmune hemolytic anemia. (18320220)	Ozbay Hosnut F.... Ozbek N.	2008	G6PD
11	Chronic lymphocytic leukemia cells bind and present the erythrocyte protein band 3: possible role as initiators of autoimmune hemolytic anemia. (18714043)	Galletti J.... Giordano M.	2008	SLC4A1
12	Treatment of severe refractory autoimmune hemolytic anemia in B-cell chronic lymphocytic leukemia with alemtuzumab (humanized CD52 monoclonal antibody). (17215854)	Karlsson C.... Lundin J.	2007	CD52
13	Marked hyperbilirubinemia associated with the heme oxygenase-1 gene promoter microsatellite polymorphism in a boy with autoimmune hemolytic anemia. (17325212)	Immenschuh S.... Bonkovsky H.L.	2007	HMOX1
14	Primary diffuse large B-cell lymphoma of the bone marrow complicated with autoimmune hemolytic anemia and erythroid hypoplasia (17695307)	Sumi M.... Kobayashi H.	2007	HP
15	Autoimmune hemolytic anemia in HCV/HIV coinfected pat ients during treatment with pegylated alpha-2a interferon plus ribavirin. (18200424)	Vilar F.C.... Figueiredo J.F.	2007	IFNA2
16	De novo CD5-positive diffuse large B-cell lymphoma associated with autoimmune hemolytic anemia presenting as erythroid hypoplasia (16910573)	Kuroda H.... Niitsu Y.	2006	HP
17	IL-10 and the cytokine network in the pathogenesis of human autoimmune hemolytic anemia. (16126942)	Toriani-Terenzi C.... Fagiolo E.	2005	IL2, IL4, IFNG
18	Aortic valve replacement for a patient with glucose-6-phosphate dehydrogenase deficiency and autoimmune hemolytic anemia. (15985145)	Tas S.... Yakut C.	2005	G6PD
19	Coombs-positive autoimmune hemolytic anemia in Crohn' s disease. (15879729)	Plikat K.... SchAPlmerich J.	2005	TNF
20	Acquired von Willebrand syndrome with autoimmune hemolytic anemia (15103936)	Sakai M.... Shirahata A.	2004	VWF
21	Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. (14563012)	Fagiolo E.... Toriani-Terenzi C.	2003	IL4
22	Regulation of the immune response by natural IgM: lessons from warm autoimmune hemolytic anemia. (12871191)	Stahl D.... Sibrowski W.	2003	CD40LG
23	Quantitation of red cell-bound IgG, IgA, and IgM in patients with autoimmune hemolytic anemia and blood donors by enzyme-linked immunosorbent assay. (15373694)	Bencomo A.A.... Alfonso M.E.	2003	CD40LG
24	Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia. (11699422)	Katayama H.... Takahashi K.	2001	HP
25	Crescentic glomerulonephritis with positive antineutrophil cytoplasmic autoantibody specific for myeloperoxidase associated with autoimmune hemolytic anemia and thrombocytopenic purpura. (10939540)	Ohhashi J.... Miyazaki Y.	2000	MPO
26	Autoimmune hemolytic anemia in a patient with chronic lymphocytic leukemia and renal cell carcinoma after treatment with high-dose intravenous bolus interleukin-2. (10916762)	Schlegel P.J.... Ward J.H.	2000	IL2
27	Application of the gel test using and anti-IgA antiglobulin for the immunologic diagnosis of autoimmune hemolytic anemia with a negative direct Coombs test (10472686)	Meyer F.... Rigal D.	1999	CD40LG
28	Fatal autoimmune hemolytic anemia in a child due to warm-reactive immunoglobulin M antibody. (9787330)	Friedmann A.M.... Casella J.F.	1998	CD40LG
29	Hemostatic disorders as a complication of autoimmune hemolytic anemia in dogs (9499627)	Mischke R.	1998	F3
30	Ovarian dermoid cyst-associated autoimmune hemolytic anemia: a case report with emphasis on pathogenic mechanisms. (8623764)	Cobo F.... Rozman C.	1996	ODC1
31	A case of herpetiform pemphigus associated with autoimmune hemolytic anemia: detection of autoantibodies against multiple epidermal antigens. (8829509)	Shimizu K.... Nishikawa T.	1996	DSG1, DST
32	Successful control of refractory and life-threatening autoimmune hemolytic anemia with intravenous immunoglobulins in a man with the primary antiphospholipid syndrome. (8959944)	Vandenberghe P.... Verhoef G.E.	1996	APOH
33	Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome). (8867725)	Kojima K.... Harada M.	1996	IL4, IL5, IGHE
34	Aggressive CD5-positive diffuse large B cell lymphoma showing c-myc rearrangements developed in a patient with autoimmune hemolytic anemia. (8713579)	Sonoki T.... Takatsuki K.	1996	MYC
35	Autoimmune hemolytic anemia during alpha interferon treatment in nine patients with hematological diseases. (8767532)	Andriani A.... Rotoli B.	1996	IFNA1
36	A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis. (8606041)	Kazuta Y.... Kasukawa R.	1995	IFNB1, IFNA1
37	Autoimmune hemolytic anemia reactivated by alpha-interferon therapy in a case of chronic active C-type hepatitis (7783339)	Katayama T.... Kobayashi M.	1995	IFNA1
38	High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)	Fagiolo E.... Pozzetto U.	1994	IL2RA, IL2, IL4
39	The role of anticardiolipin autoantibodies in the pathogenesis of autoimmune hemolytic anemia in systemic lupus erythematosus. (8014933)	Sthoeger Z.... Geltner D.	1993	APOH
40	Angioedema due to acquired complement-C1-inhibitor deficiency in a female patient with non-Hodgkin lymphoma and autoimmune hemolytic anemia (1862309)	Beretta K.R.... Cavalli F.	1991	SERPING1

Genes related to autoimmune hemolytic anemia according to GeneCards:

(show all 49)

id	Symbol	Description	Score	GeneCards Section Context
1	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
2	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
3	HP	haptoglobin	11.0	Publications
4	GYPA	glycophorin A (MNS blood group)	11.0
5	CD40LG	CD40 ligand	11.0	Publications
6	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
7	IGHV3-11	immunoglobulin heavy variable 3-11 (gene/pseudogene)	11.0	Disorders
8	IGHV4-59	immunoglobulin heavy variable 4-59	11.0	Disorders
9	CD52	CD52 molecule	11.0	Publications
10	CHAD	chondroadherin	11.0
11	LAG3	lymphocyte-activation gene 3	11.0	Publications
12	WRB	tryptophan rich basic protein	11.0
13	T	T, brachyury homolog (mouse)	11.0	Publications
14	HPR	haptoglobin-related protein	11.0
15	KEL	Kell blood group, metallo-endopeptidase	11.0
16	C1S	complement component 1, s subcomponent	11.0	Publications
17	SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	11.0	Publications
18	CD47	CD47 molecule	11.0	Publications
19	SIRPA	signal-regulatory protein alpha	11.0	Publications
20	DSG1	desmoglein 1	11.0	Publications
21	PIGA	phosphatidylinositol glycan anchor biosynthesis, class A	11.0
22	GYPE	glycophorin E (MNS blood group)	11.0
23	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications
24	RHCE	Rh blood group, CcEe antigens	11.0
25	RHD	Rh blood group, D antigen	11.0
26	STIM1	stromal interaction molecule 1	11.0
27	IL17A	interleukin 17A	11.0	Publications
28	ODC1	ornithine decarboxylase 1	11.0	Publications
29	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
30	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
31	DST	dystonin	11.0	Publications
32	MPO	myeloperoxidase	11.0	Publications
33	IFNA2	interferon, alpha 2	11.0	Publications
34	IFNA1	interferon, alpha 1	11.0	Publications
35	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
36	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
37	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
38	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
39	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
40	IL4	interleukin 4	11.0	Publications
41	VWF	von Willebrand factor	11.0	Publications
42	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0
43	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
44	IL10	interleukin 10	11.0	Publications
45	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
46	IL2	interleukin 2	11.0	Publications
47	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
48	TNF	tumor necrosis factor	11.0	Publications
49	IFNG	interferon, gamma	11.0	Publications

Pathways related to autoimmune hemolytic anemia according to GeneDecks:

(show all 46)

id	Pathway	Score	Top Affiliating Genes
1	RIG-I-like receptor signaling pathway20	10.4	IFNB1
2	OX40 Pathway36	10.3	IL5, IL4
3	Immune response Lectin Induced complement pathway10	10.3	CR1, CD55, SERPING1
4	Lymphocyte Signaling3	10.2	IL2RA, HMOX1
5	Immune response_Lectin induced complement pathway41	10.2	CR1, CD55, CD59, SERPING1
6	Immune response Classic complement pathway10	10.1	C1S, CR1, CD55, CD59, SERPING1
7	Immune response_Classical complement pathway41	10.1	C1S, CR1, CD55, CD59, SERPING1
8	Immune response IL-2 activation and signaling pathway10	10.1	SIRPA, MYC
9	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.0	IL2, IL2RA
10	RAR-Gamma-RXR-Alpha Degradation36	10.0	IL2
11	Immune response_Alternative complement pathway41	9.8	CR1, CD55, CD59
12	NFAT Signaling and Lymphocyte Interactions36	9.7	IL2, IL4, IL5
13	PGC1Alpha Pathway36	9.7	IL5, IL4, IL2
14	Immune response Alternative complement pathway10	9.6	CR1, CD55, CD59
15	Immune response_IL-2 activation and signaling pathway41	9.3	SIRPA, IL2RA, IL2, MYC
16	Intestinal immune network for IgA production20	9.3	IL5, IL4, IL2, IL10, CD40LG
17	Pertussis20	9.0	C1S, TNF, IL10, SERPING1
18	Asthma20	9.0	TNF, IL5, IL4, IL10, CD40LG
19	African trypanosomiasis20	9.0	TNF, HPR, IFNG, IL10
20	Complement and coagulation cascades20	9.0	C1S, CR1, F3, F5, CD55, CD59
21	IL-10 Pathway36	8.9	MYC, IL10, HMOX1, TNF
22	Autoimmune thyroid disease20	8.9	IFNA2, IFNA1, IL5, IL4, IL2, IL10
23	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.8	IL10, IL2, IL2RA, TNF
24	Systemic lupus erythematosus20	8.8	C1S, TNF, IFNG, IL10, CD40LG
25	Natural killer cell mediated cytotoxicity20	8.8	TNF, IFNG, IFNB1, IFNA2, IFNA1
26	Measles20	8.6	IFNG, IFNB1, IFNA2, IFNA1, IL4, IL2RA
27	Hematopoietic cell lineage20	8.6	CR1, TNF, IL5, IL4, IL2RA, GYPA
28	Malaria20	8.6	CR1, TNF, IFNG, IL10, GYPA, CD40LG
29	Th1 Differentiation37	8.5	TNF, IFNG, IL2, IL10
30	MIF Mediated Glucocorticoid Regulation36	8.5	TNF, IL5, IL4, IL2, IL10
31	MIF Regulation of Innate Immune Cells36	8.4	TNF, IL5, IL4, IL2, IL10
32	Leishmaniasis20	8.4	CR1, TNF, IFNG, IL4, IL10
33	Chagas disease (American trypanosomiasis)20	8.3	TNF, IFNG, IFNB1, IL2, IL10
34	all-trans-Retinoic Acid Signaling in Brain36	8.3	TNF, IL5, IL4, IL2, IL10
35	PEDF Induced Signaling36	8.3	TNF, IL5, IL4, IL2, IL10
36	Tuberculosis20	8.1	CR1, TNF, IFNG, IFNB1, IFNA2, IFNA1
37	THC Differentiation Pathway36	8.0	TNF, IFNG, IL4, IL2RA, IL2, IL10
38	IL-6 Pathway36	8.0	TNF, IL5, IL4, IL2, IL10, MYC
39	Allograft rejection20	8.0	TNF, IFNG, IL5, IL4, IL2, IL10
40	T cell receptor signaling pathway20	8.0	TNF, IFNG, IL5, IL4, IL2, IL10
41	Endothelin-1 Signaling Pathway36	7.9	TNF, IL5, IL4, IL2, IL10, MYC
42	STAT3 Pathway36	7.8	TNF, IL5, IL4, IL2RA, IL2, IL10
43	Jak-STAT signaling pathway20	7.5	IFNG, IFNB1, IFNA2, IFNA1, IL5, IL4
44	JAK-STAT Pathway36	7.5	IFNG, IFNB1, IFNA2, IFNA1, IL5, IL4
45	Cytokine Network36	7.5	IL10, TNF, IFNG, IFNB1, IFNA2, IFNA1
46	Cytokine-cytokine receptor interaction20	6.9	IFNA1, IFNA2, IFNB1, IFNG, TNF, IL5

Compounds related to autoimmune hemolytic anemia according to GeneDecks:

(show top 50)    (show all 283)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	APOH, PIGA
2	ivig32	10.3	IFNB1, DSG1, VWF
3	polyethylene glycol32	10.1	G6PD, HMOX1, HP, IFNA2, MPO
4	pge232	9.9	ODC1, HMOX1, IL5, IL17A, HP
5	ascorbic acid32 18	10.6	ODC1, CD40LG, IFNA2, G6PD, IL2RA, IGHE
6	aspartate32	9.6	IFNB1, RHD, HP, F5, CD55, CD40LG
7	n acetylcysteine32	9.4	ODC1, IGHE, IL2RA, VWF, CD79A
8	heparin32 9 18 9	12.3	VWF, MPO, CR1, HP, F3, CD55
9	endotoxin32	9.1	F5, APOH, CR1, IFNB1, F3, HP
10	phosphatidylserine32 9 9	11.1	VWF, WRB, GYPE, CD47, CD79A, F5
11	rituximab32 34 9 9	11.8	DSG1, C1S, IL2RA, IL2, CD59, CD79A
12	glatiramer acetate32 9 9	10.4	IFNA1, IL10, IL2, IL4, IL5, IFNB1
13	cysteine32	8.4	CD55, WRB, SLC4A1, HPR, IFNG, IL5
14	ribavirin32 34 9 9	11.3	IL10, CD40LG, IFNG, IL2, IL4, G6PD
15	thyroxine32 18	9.3	IFNB1, G6PD, HP, VWF, IFNA2, IGHE
16	azathioprine32 34 9 9	11.3	G6PD, IFNB1, CD79A, CD59, IL10, IL2
17	vegf32	8.2	VWF, F3, HP, HMOX1, F5, IFNB1
18	imiquimod32 42 9 9	11.1	IFNA2, IFNB1, TNF, IFNG, IFNA1, IL5
19	aspirin32 34 18	10.1	F5, G6PD, C1S, HMOX1, ODC1, HP
20	con a32	7.9	IL5, IL2RA, CD79A, IL10, IL2, HP
21	folate32	7.8	VWF, MYC, CD40LG, IL2RA, APOH, IGHE
22	polysaccharide32	7.8	IGHE, IL2RA, HP, F3, IFNB1, CD52
23	mycophenolate mofetil32 9 9	9.8	IFNA1, IL2RA, CD79A, CD40LG, IL2, F5
24	il-1232	7.7	IFNA1, CD40LG, IL5, IL4, TNF, IL2
25	infliximab32 9 9	9.7	IFNG, TNF, IGHE, IFNA2, IL2RA, APOH
26	chloroquine32 34 9 9	10.6	TNF, G6PD, HP, IFNB1, CD79A, IL4
27	taurine chloramine32	7.6	HMOX1, MPO, IL2, TNF, F5, IFNG
28	okt332	7.5	TNF, CD79A, IL10, IL2, IL2RA, IL4
29	polyinosinic-polycytidylic acid32	7.5	IL10, IFNA1, IFNB1, IFNG, TNF, IL4
30	phospholipid32	7.5	SLC4A1, HP, VWF, CD59, F3, F5
31	pentoxifylline32 9 9	9.4	IL10, IL2, IL2RA, IL4, IFNG, F3
32	thalidomide32 42 9 9	10.4	IL2, IL10, CD40LG, IL5, IFNA1, IFNA2
33	creatinine32	7.4	IGHE, APOH, HP, F3, F5, G6PD
34	il 1032	7.3	TNF, IFNG, IL5, IL4, IL2RA, IL2
35	lactate32	7.1	CD40LG, SLC4A1, HP, ODC1, TNF, HMOX1
36	2,5-oligoadenylate32	7.1	ODC1, TNF, IFNG, IFNB1, IFNA2, IFNA1
37	neopterin32	6.9	TNF, HP, IFNG, IFNB1, IFNA2, IFNA1
38	alanine32	6.9	IFNA2, HP, IFNB1, IFNA1, HPR, HMOX1
39	herbimycin a32 42	7.8	IFNB1, TNF, IFNG, IL5, IL4, IL2
40	cyclosporin a32 42	7.7	ODC1, HMOX1, HP, IFNA1, IGHE, IL5
41	actinomycin d32	6.5	IFNA1, IGHE, IL4, IL2, IL17A, CD55
42	indomethacin32 9 9	8.1	MYC, MPO, CD79A, CD40LG, IL17A, IL2
43	nitric oxide32 9 18 9	9.1	ODC1, TNF, F5, CR1, C1S, HMOX1
44	histamine32 18	6.9	VWF, MPO, CD79A, CD55, ODC1, TNF
45	tacrolimus32 34 9 9	8.7	IL2, IL17A, IL10, CD79A, MYC, IL2RA
46	cycloheximide32	5.6	MYC, ODC1, DST, CR1, HMOX1, F3
47	prednisolone32 9 9	7.5	IFNA2, CR1, TNF, IFNA1, IGHE, APOH
48	serine32	5.5	G6PD, DSG1, RHD, ODC1, HPR, HP
49	dexamethasone32 42 34 9 9	9.3	TNF, HMOX1, HPR, HP, IFNG, IFNB1
50	retinoic acid32 42 18	7.0	F5, IFNA1, IFNA2, IFNB1, IGHE, CD47

Cellular components related to autoimmune hemolytic anemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	7.8	SLC4A1, STIM1, RHD, RHCE, CR1, TNF
2	external side of plasma membrane	GO:009897	7.7	TNF, IFNG, IL4, IL17A, CD40LG, CD79A
3	extracellular region	GO:005576	7.4	IFNB1, IFNG, F5, HP, IFNA2, IL5
4	extracellular space	GO:005615	5.4	MPO, TNF, HMOX1, HP, F3, F5

Biological processes related to autoimmune hemolytic anemia according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of T-helper 2 cell cytokine production	GO:2000552	10.3	IFNB1, IFNA2
2	blood coagulation, intrinsic pathway	GO:007597	10.1	VWF, SERPING1, APOH
3	complement activation, classical pathway	GO:006958	10.1	C1S, CR1, CD55, SERPING1
4	regulation of isotype switching	GO:045191	10.0	IL4, IL10
5	B cell proliferation	GO:042100	9.8	IFNB1, IL10, CD40LG, CD79A
6	B cell differentiation	GO:030183	9.6	CD79A, CD40LG, IL10, IL4
7	positive regulation of B cell proliferation	GO:030890	9.6	IL5, IL4, IL2, CD40LG
8	positive regulation of B cell apoptotic process	GO:002904	9.6	IL10, MYC
9	positive regulation of MHC class II biosynthetic process	GO:045348	9.5	CD40LG, IL10, IL4, IFNG
10	positive regulation of isotype switching to IgG isotypes	GO:048304	9.5	IL2, IL4, IFNG
11	cell surface receptor signaling pathway	GO:007166	9.4	IFNG, IFNB1, IFNA2, IL2RA, CD59, LAG3
12	positive regulation of podosome assembly	GO:071803	9.4	IL5, TNF
13	positive regulation of vitamin D biosynthetic process	GO:060557	9.4	TNF, IFNG
14	positive regulation of osteoclast differentiation	GO:045672	9.2	TNF, IFNG, IL17A
15	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.0	TNF, IFNG
16	negative regulation of growth of symbiont in host	GO:044130	9.0	TNF, IFNG, IL10
17	positive regulation of chemokine biosynthetic process	GO:045080	9.0	TNF, HMOX1, IFNG, IL4
18	receptor biosynthetic process	GO:032800	8.9	TNF, IL10
19	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.9	IL10, IL4, IL5, TNF
20	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	8.8	TNF, F3, IFNB1, MYC
21	response to virus	GO:009615	8.7	ODC1, TNF, IFNG, IFNB1, IFNA2
22	blood coagulation	GO:007596	8.6	SIRPA, STIM1, F3, F5, IFNB1, IFNA2
23	inflammatory response	GO:006954	8.6	TNF, IFNA2, IL5, IL17A, IL10, CD40LG
24	anti-apoptosis	GO:006916	8.3	TNF, HMOX1, F3, IL2, IL10, CD40LG

Molecular functions related to autoimmune hemolytic anemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	7.0	CD40LG, IFNG, IFNB1, IFNA2, IL5, IL4