MCID: ATM010
MIFTS: 57

Autoimmune Hemolytic Anemia malady

Immune diseases, Genetic diseases categories

Summaries for Autoimmune Hemolytic Anemia

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hemolytic anemia and leukemia. An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Classical antibody-mediated complement activation and Hematopoietic cell lineage. The drugs cyclophosphamide and immunoglobulins, intravenous and the compounds sulfasalazine and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:63 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM:46 205700

Aliases & Classifications for Autoimmune Hemolytic Anemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Immune diseases


Aliases & Descriptions:

autoimmune hemolytic anemia 8 42 10 44 60
idiopathic autoimmune hemolytic anemia 42
familial auto-immune hemolytic anemia 42
acquired autoimmune hemolytic anemia 42
autoimmune hemolytic anemia nos 8
autoimmune haemolytic anaemias 8
autoimmune haemolytic anaemia 8
autoimmune hemolytic anemias 8
anemia hemolytic autoimmune 42
immuno-hemolytic anemia 42


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Disease Ontology8 DOID:718
NCIt39 C34378
ICD9CM27 283.0
MeSH34 D000744
OMIM46 205700

Related Diseases for Autoimmune Hemolytic Anemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hemolytic Anemia family:

autoimmune hemolytic anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia32.2PIGA, CD59, G6PD, HP, CD55
2leukemia31.4PIGA, SIRPA, IL17A, CD59, CD52, GYPA
3hepatitis31.4HP, CD40LG
4chronic lymphocytic leukemia31.3CD55, CD52, CD59, CD40LG
5thrombocytopenia31.1HP, PIGA, CD40LG, HPR
6hepatitis c31.0CD40LG, HP
7deficiency anemia31.0CD55, CD59, HP, HPR, PIGA, G6PD
8lupus erythematosus30.9C1S, CD40LG
9systemic lupus erythematosus30.9IL17A, CD55, CD59, CD40LG, C1S
10acute leukemia30.8IL17A
11glomerulonephritis30.7CD55, CD59, CD40LG
12non-hodgkin lymphoma30.6C1S, CD52, CD59, CD55
13hereditary spherocytosis30.6G6PD, GYPA
14pneumonia30.5IL17A, GYPA
15pancreatitis30.4C1S
16sickle cell anemia30.4HP, G6PD
17hemoglobinuria30.4CD59, CD55, HP, PIGA, G6PD
18arthritis30.4CD59, IL17A, HPR, CD55, HP
19pancytopenia30.2CD55, HP
20connective tissue disease30.2CD40LG, C1S
21congenital hemolytic anemia30.2HP, G6PD
22psoriasis30.2CD55, IL17A, CD59
23malaria30.2HP, GYPA, G6PD, HPR
24multiple sclerosis30.2CD59, CD55, CD52, IL17A
25pancreatic cancer30.2SIRPA, HP, CD59, CD55
26chronic myeloid leukemia30.2SIRPA, CD55, CD59, G6PD
27ovarian cancer30.2IL17A, HPR, HP, CD59
28rheumatoid arthritis30.2CD40LG, CD59, CD55, CD52, HP, C1S
29diabetes mellitus30.2HPR, HP, CD40LG, G6PD
30autoimmune hepatitis10.9
31hepatitis a10.7
32pure red-cell aplasia10.7
33autoimmune thrombocytopenic purpura10.7
34purpura10.7
35primary biliary cirrhosis10.6
36antiphospholipid syndrome10.5
37ulcerative colitis10.5
38evans' syndrome10.5
39common variable immunodeficiency10.5
40hodgkin's lymphoma10.5
41crohn's disease10.4
42macroglobulinemia10.4
43splenic infarction10.4
44diffuse large b-cell lymphoma10.4
45warm antibody hemolytic anemia10.4
46drug-induced autoimmune hemolytic anemia10.4
47autoimmune thyroiditis10.4
48hemophagocytic lymphohistiocytosis10.4
49hepatitis e10.4
50splenic marginal zone lymphoma10.4

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Clinical Features for Autoimmune Hemolytic Anemia

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Sources:
46OMIM
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Clinical features from OMIM:

205700

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Search CenterWatch for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Autoimmune Hemolytic Anemia

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Anatomical Context for Autoimmune Hemolytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

32
Testes, T cells, B cells, Liver, Bone marrow, Bone, Thyroid, Kidney, Heart, Nk cells, Monocytes, Myeloid, Brain, Colon, Pancreas

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0CD40LG, CD59, CD55, HP, IL17A, T
2MP:00053979.5LAG3, G6PD, PIGA, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

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50PubMed
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Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
2
Megadose Methyl-Prednisolone (MDMP) for Autoimmune Hemolytic Anemia. (24385798)
2013
3
Primary SjAPgren syndrome presenting with hemolytic anemia and pure red cell aplasia following delivery due to Coombs-negative autoimmune hemolytic anemia and hemophagocytosis. (24126397)
2013
4
Proliferative glomerulonephritis with monoclonal IgG deposits in a patient with autoimmune hemolytic anemia. (23725649)
2013
5
Demyelinating neuropathy and autoimmune hemolytic anemia in a patient with pancreatic cancer. (23903509)
2013
6
Warm autoimmune hemolytic anemia secondary to Plasmodium ovale infection: a case report and review of the literature. (24148713)
2013
7
Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant. (23671728)
2013
8
Autoimmune hemolytic anemia with gel-based immunohematology tests. (23525616)
2013
9
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
10
IgA-induced autoimmune hemolytic anemia in a patient with antiphospholipid syndrome. (22988389)
2012
11
Critical role of Th17 cells in development of autoimmune hemolytic anemia. (22960264)
2012
12
Production of the effector cytokine interleukin-17, rather than interferon-I^, is more strongly associated with autoimmune hemolytic anemia. (22419580)
2012
13
Autoimmune hemolytic anemia due to auto anti-N in a patient with sepsis. (22985536)
2012
14
New insights into childhood autoimmune hemolytic anemia: a French national observational study of 265 children. (21228033)
2011
15
Mycoplasma pneumoniae associated with severe autoimmune hemolytic anemia in a child with homozygous beta-thalassemia. (21780047)
2011
16
IgA-mediated autoimmune hemolytic anemia in an infant. (21370419)
2011
17
Severe autoimmune hemolytic anemia associated with IgM warm auto-antibodies in primary SjAPgren's syndrome. (20374393)
2010
18
Brucellosis-induced autoimmune hemolytic anemia treated with rituximab. (20823278)
2010
19
Tolosa-Hunt syndrome in a patient with autoimmune hemolytic anemia. (20718692)
2010
20
Clinical significance of serologic markers related to red blood cell autoantibodies production after red blood cell transfusion-severe autoimmune hemolytic anemia occurring after transfusion and alloimmunization: successful treatment with rituximab. (19374728)
2009
21
Severe autoimmune hemolytic anemia complicated with liver decompensation and invasive aspergillosis in a patient with chronic hepatitis C during treatment with peg-interferon-a and ribavirin. (19337648)
2009
22
A case report of refractory warm autoimmune hemolytic anemia treated with plasmapheresis and rituximab. (18387171)
2008
23
Non-autoimmune hemolytic anemia with clostridium ramosum bacteremia. (24179346)
2008
24
A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura. (18166805)
2008
25
Large granular lymphocyte leukemia (LGL) in a child with hyper IgM syndrome and autoimmune hemolytic anemia. (16767728)
2008
26
Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia. (17709498)
2007
27
Treatment of severe refractory autoimmune hemolytic anemia in B-cell chronic lymphocytic leukemia with alemtuzumab (humanized CD52 monoclonal antibody). (17215854)
2007
28
Two-step mechanism of virus-induced autoimmune hemolytic anemia. (17785301)
2007
29
Transient thrombocytopenia after incompatible red blood transfusion in an infant girl with autoimmune hemolytic anemia. (16641534)
2006
30
Autoimmune hemolytic anemia in India: clinico-hematological spectrum of 79 cases. (16522555)
2006
31
Autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia and gastric cancer appeared in a patient with myasthenia gravis. (16679706)
2006
32
Chronic eosinophilic leukemia presenting with autoimmune hemolytic anemia and erythrophagocytosis by eosinophils. (16680737)
2006
33
CD4+CD25+ regulatory T cells control induction of autoimmune hemolytic anemia. (15637139)
2005
34
Autoimmune hemolytic anemia: magnetic resonance findings. (15528003)
2004
35
Autoimmune hemolytic anemia associated with benign ovarian cyst: a case report and review of literature. (14646159)
2003
36
Investigation of the mechanism of drug-induced autoimmune hemolytic anemia in cynomolgus monkeys elicited by a repeated-dose of a humanized monoclonal antibody drug. (12974605)
2003
37
Red blood cell transfusion in autoimmune hemolytic anemia. (14564173)
2003
38
Rituximab for immune cytopenia in adults: idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and Evans syndrome. (14601692)
2003
39
Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. (11986200)
2002
40
Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice. (12093879)
2002
41
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
42
HIV-associated autoimmune hemolytic anemia: an update. (11359664)
2001
43
Severe cytomegalovirus-triggered autoimmune hemolytic anemia complicating vertically acquired HIV infection. (10706183)
2000
44
Erythropoiesis: Splenic Immunoglobulin Variable Region Genes Encoding Red Blood Cell Binding Fab Fragments in Autoimmune Hemolytic Anemia. (11399561)
1999
45
Comparative response to splenectomy in Coombs-positive autoimmune hemolytic anemia with or without associated disease. (10367787)
1999
46
Eosinophilic fasciitis following idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia and Hashimoto's disease. (10592421)
1999
47
Autoimmune hemolytic anemia. (9773255)
1998
48
Anti-red blood cell autoantibody transgenic mice: murine model of autoimmune hemolytic anemia. (8850293)
1996
49
Intravenous immunoglobulin therapy in an infant with autoimmune hemolytic anemia associated with necrotic hepatitis and peliosis. (8788295)
1996
50
Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome). (8867725)
1996

Genetic Variations for Autoimmune Hemolytic Anemia

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Expression for genes affiliated with Autoimmune Hemolytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

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53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 55SinoBiological
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Compounds for genes affiliated with Autoimmune Hemolytic Anemia

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1sulfasalazine44 28 49 1113.6G6PD, CD40LG, HP
2anaphylatoxin4410.6HP, CD55, CD59
3alemtuzumab44 1111.6CD52, CD40LG, PIGA
4glycolipid4410.6CD55, CD59, GYPA
5ribavirin44 49 1112.6G6PD, CD40LG, HP
6thiobarbituric acid4410.5HP, G6PD
7fludarabine44 1111.5CD40LG, CD55, CD52
8lactose44 1111.5G6PD, CD40LG, HP, HPR
9vitamin b124410.5HP, CD40LG, G6PD
1023-diphosphoglycerate4410.5HP, G6PD
11aspirin44 49 28 2413.5C1S, G6PD, CD40LG, CD59, HP
12sucrose44 11 2412.5HP, CD55, CD59, DSG1
13sialic acid4410.5GYPA, CD59, CD55, CD52, HP
14actinomycin d4410.5IL17A, HP, CD55, CD40LG, G6PD
15cyclosporin a44 28 5912.4CD40LG, CD59, CD55, HP, IL17A
16creatinine4410.4G6PD, CD40LG, CD55, HP, IL17A
17polyethylene glycol4410.4HP, CD40LG, G6PD
18zinc protoporphyrin4410.3HP, G6PD
19serine4410.3G6PD, DSG1, CD55, HP, HPR, SERPING1
20heparin44 28 11 2413.3C1S, CD40LG, CD55, HP, SERPING1
21polysaccharide4410.3CD40LG, CD55, CD52, HP
22rituximab44 49 1112.3HP, CD52, CD55, CD59, CD40LG, DSG1
23fructose-1,6-bisphosphate4410.3HPR, G6PD
24alanine4410.3GYPA, CD40LG, CD55, HP, HPR, SERPING1
25tuberculin4410.2CD40LG, HP
26estrogen4410.2G6PD, CD40LG, CD55, HP, HPR, IL17A
27lipid4410.1G6PD, WRB, GYPA, CD59, CD55, HP
28glucose4410.0G6PD, CD59, CD55, HP, HPR, SIRPA
29atorvastatin44 49 28 11 2414.0CD55, CD59, CD40LG

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

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16Gene Ontology
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Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.2LAG3, IL17A, CD40LG, GYPA

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory burstGO:04573010.3CD52, CD55
2complement activation, classical pathwayGO:0069589.9SERPING1, CD55, C1S

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.3HPR, HP

Products for genes affiliated with Autoimmune Hemolytic Anemia

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  • Antibodies
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Sources for Autoimmune Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet