MCID: ATM010
MIFTS: 55

Autoimmune Hemolytic Anemia malady

Immune, Genetic categories

Summaries for Autoimmune Hemolytic Anemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hepatitis c and thrombocytopenia. An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Classical antibody-mediated complement activation and Hematopoietic cell lineage. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds sulfasalazine and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:64 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM:47 205700

Aliases & Classifications for Autoimmune Hemolytic Anemia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 27ICD9CM, 57SNOMED-CT, 35MeSH, 47OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic
Anatomical: Immune


Aliases & Descriptions:

autoimmune hemolytic anemia 8 43 10 45 61
idiopathic autoimmune hemolytic anemia 43
familial auto-immune hemolytic anemia 43
acquired autoimmune hemolytic anemia 43
autoimmune hemolytic anemia nos 8
autoimmune haemolytic anaemias 8
autoimmune haemolytic anaemia 8
autoimmune hemolytic anemias 8
anemia hemolytic autoimmune 43
immuno-hemolytic anemia 43


External Ids:

Disease Ontology8 DOID:718
NCIt40 C34378
ICD9CM27 283.0
MeSH35 D000744
OMIM47 205700

Related Diseases for Autoimmune Hemolytic Anemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.3HP, CD40LG
2thrombocytopenia31.1PIGA, CD40LG, HP, HPR
3deficiency anemia30.9HPR, HP, CD55, CD59, PIGA, G6PD
4systemic lupus erythematosus30.9C1S, CD40LG, CD59, CD55, IL17A
5acute leukemia30.8IL17A
6hereditary spherocytosis30.7G6PD, GYPA
7nephritis30.6IL17A, CD55, CD40LG
8sickle cell anemia30.4HP, G6PD
9hemoglobinuria30.4G6PD, PIGA, CD59, CD55, HP
10arthritis30.4CD59, CD55, HP, HPR, IL17A
11thromboembolism30.3G6PD
12pancytopenia30.2HP, CD55
13paroxysmal nocturnal hemoglobinuria30.2G6PD, PIGA, CD59, CD55, HP
14chronic myeloid leukemia30.2SIRPA, CD55, CD59, G6PD
15sepsis30.2C1S, CD55, IL17A, SERPING1
16autoimmune hepatitis10.9
17hepatitis a10.9
18refractory anemia10.9
19autoimmune thrombocytopenic purpura10.7
20mixed-type autoimmune hemolytic anemia10.7
21warm antibody hemolytic anemia10.7
22t-cell leukemia10.6
23hepatitis e10.6
24primary biliary cirrhosis10.6
25leukemia, t-cell, chronic10.6
26antiphospholipid syndrome10.5
27ulcerative colitis10.5
28hepatitis c virus10.5
29drug-induced autoimmune hemolytic anemia10.5
30autoimmune hemolytic anemia, warm type10.5
31evans' syndrome10.5
32common variable immunodeficiency10.5
33macroglobulinemia10.5
34cold agglutinin disease10.5
35lymphoma, diffuse large cell10.5
36multicentric castleman disease10.5
37autoimmune thyroiditis10.4
38hemophagocytic lymphohistiocytosis10.4
39splenic infarction10.4
40hepatitis d10.4
41splenic marginal zone lymphoma10.4
42thyroiditis10.4
43tuberculosis10.4
44hematopoietic stem cell transplantation10.4
45rubella10.3
46ovarian lymphoma10.3
47thrombotic thrombocytopenic purpura10.3
48chronic mucocutaneous candidiasis10.3
49purine nucleoside phosphorylase deficiency10.3
50adult syndrome10.3

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Clinical Features for Autoimmune Hemolytic Anemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

205700

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Search CenterWatch for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Autoimmune Hemolytic Anemia

Anatomical Context for Autoimmune Hemolytic Anemia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

33
Bone marrow, Brain, Heart, Small intestine, Colon, Kidney, Liver, Pancreas, Thyroid, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0CD40LG, CD59, CD55, HP, IL17A, T
2MP:00053979.5LAG3, G6PD, PIGA, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

Sources:
51PubMed
See all sources

Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Humoral immune mechanism of liver injury in giant cell hepatitis with autoimmune hemolytic anemia. (23969541)
2014
2
Autoimmune hemolytic anemia occurred in burn patient: A case report. (24045069)
2013
3
A case of autoimmune hemolytic anemia with anti-D specificity in a 1-year-old child. (24046918)
2013
4
Autoimmune hemolytic anemia with gel-based immunohematology tests: neural network analysis. (24371011)
2013
5
Current approaches for the treatment of autoimmune hemolytic anemia. (23689532)
2013
6
C1-esterase inhibitor concentrate rescues erythrocytes from complement-mediated destruction in autoimmune hemolytic anemia. (23411737)
2013
7
Graves' disease causing pancytopenia and autoimmune hemolytic anemia at different time intervals: a case report and a review of the literature. (24319463)
2013
8
Splenic infarct in a patient with autoimmune hemolytic anemia. (24385738)
2012
9
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
10
Naturally occurring regulatory T cells and interleukins 10 and 12 in the pathogenesis of idiopathic warm autoimmune hemolytic anemia. (21721376)
2011
11
Interferon-Beta-1b Induced Autoimmune Hemolytic Anemia in a Patient with MS: A Case Report. (22737466)
2011
12
Change and significance of Th17 cells and its secretive IL-17 in patients with autoimmune hemolytic anemia]. (21651870)
2011
13
Geoepidemiology of autoimmune hemolytic anemia. (19932202)
2010
14
Dramatic response to rituximab in a child with severe cold autoimmune hemolytic anemia arising after allogeneic hematopoietic SCT. (19448677)
2010
15
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
16
Serologic findings in autoimmune hemolytic anemia associated with immunoglobulin M warm autoantibodies. (18980619)
2009
17
Autoimmune hemolytic anemia associated with ulcerative colitis: response to infliximab. (19727107)
2009
18
Posttransplant autoimmune hemolytic anemia and other autoimmune cytopenias are increased in very young infants undergoing unrelated donor umbilical cord blood transplantation. (18804040)
2008
19
Autoimmune hemolytic anemia in HIV-infected patients: a hospital based study. (19143163)
2008
20
Direct antiglobulin test reactive with complement only in warm type autoimmune hemolytic anemia. (18983301)
2008
21
Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab. (17918251)
2008
22
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
23
Red cell aplasia and autoimmune hemolytic anemia following immunosuppression with alemtuzumab, mycophenolate, and daclizumab in pancreas transplant recipients. (17640860)
2007
24
Chronic lymphocytic leukemia-associated autoimmune hemolytic anemia. (17577769)
2007
25
Autoimmune hemolytic anemia preceding T-ALL in a five-year-old girl. (16020103)
2005
26
Aortic valve replacement for a patient with glucose-6-phosphate dehydrogenase deficiency and autoimmune hemolytic anemia. (15985145)
2005
27
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
28
Successful treatment with rituximab for autoimmune hemolytic anemia concomitant with proliferation of Epstein-Barr virus and monoclonal gammopathy in a post-nonmyeloablative stem cell transplant patient. (14513283)
2004
29
Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia. (15264122)
2004
30
Successful treatment of refractory autoimmune hemolytic anemia with monthly rituximab following nonmyeloablative stem cell transplantation for sickle cell disease. (15111785)
2004
31
Levofloxacin-induced autoimmune hemolytic anemia. (12841809)
2003
32
Severe autoimmune hemolytic anemia caused by a warm IgA autoantibody directed against the third loop of band 3 (RBC anion-exchange protein 1). (12473132)
2002
33
High-dose cyclophosphamide for refractory autoimmune hemolytic anemia. (12091370)
2002
34
Erythrophagocytosis assay in patients with autoimmune hemolytic anemia. (11265623)
2001
35
Acute autoimmune hemolytic anemia following DTP vaccination: report of a fatal case and review of the literature. (11824181)
2001
36
Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia. (11699422)
2001
37
Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features. (10779422)
2000
38
Autoimmune hemolytic anemia: a history. (10914417)
2000
39
HIV-associated autoimmune hemolytic anemia complicated by pulmonary embolism following a red blood cell transfusion: case report and review of the literature. (9542286)
1998
40
Severe autoimmune hemolytic anemia in eight patients treated with fludarabine. (9698219)
1998
41
The leukemic cells of chronic lymphocytic leukemia patients with autoimmune hemolytic anemia produce isotype-switched immunoglobulins that are preferentially encoded by the 51p1 and DP-50 VH genes. (9186693)
1997
42
Autoimmune hemolytic anemia with warm antibodies complicated with an intercurrent attack of hemolysis with cold agglutinins in a case of WaldenstrAPm disease. (8908641)
1996
43
Case Report: a patient with primary biliary cirrhosis and autoimmune hemolytic anemia. (8924649)
1996
44
A case of autoimmune hemolytic anemia induced by IFN-beta therapy for type-C chronic hepatitis. (8606041)
1995
45
Autoimmune hemolytic anemia in chronic mucocutaneous candidiasis. (7496919)
1994
46
Pernicious anemia, Hashimoto's thyroiditis and SjAPgren's in a woman with SLE and autoimmune hemolytic anemia. (2746580)
1989
47
Acquired angioedema, autoimmune hemolytic anemia, and lymphoma: resolution after therapy. (6898468)
1980
48
Cellular immune deficiency with autoimmune hemolytic anemia in purine nucleoside phosphorylase deficiency. (111549)
1979
49
Leukemoid reaction: an unusual manifestation of autoimmune hemolytic anemia. (4808994)
1974
50
A case of autoimmune hemolytic anemia with circulating cold agglutinins presenting for many years as "hypersplenism" and terminating in leukemia. (13967250)
1963

Genetic Variations for Autoimmune Hemolytic Anemia

Expression for genes affiliated with Autoimmune Hemolytic Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

Sources:
54Reactome, 30KEGG, 52QIAGEN, 56SinoBiological, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Autoimmune Hemolytic Anemia

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1sulfasalazine45 29 50 1113.6G6PD, CD40LG, HP
2anaphylatoxin4510.6HP, CD55, CD59
3alemtuzumab45 1111.6CD52, CD40LG, PIGA
4glycolipid4510.6CD55, CD59, GYPA
5ribavirin45 50 1112.6G6PD, CD40LG, HP
6thiobarbituric acid4510.5HP, G6PD
7fludarabine45 1111.5CD40LG, CD55, CD52
8lactose45 1111.5G6PD, CD40LG, HP, HPR
9vitamin b124510.5HP, CD40LG, G6PD
1023-diphosphoglycerate4510.5HP, G6PD
11aspirin45 50 29 2413.5C1S, G6PD, CD40LG, CD59, HP
12sucrose45 11 2412.5HP, CD55, CD59, DSG1
13sialic acid4510.5GYPA, CD59, CD55, CD52, HP
14actinomycin d4510.5IL17A, HP, CD55, CD40LG, G6PD
15cyclosporin a45 29 6012.4CD40LG, CD59, CD55, HP, IL17A
16creatinine4510.4G6PD, CD40LG, CD55, HP, IL17A
17polyethylene glycol4510.4HP, CD40LG, G6PD
18zinc protoporphyrin4510.3HP, G6PD
19serine4510.3G6PD, DSG1, CD55, HP, HPR, SERPING1
20heparin45 29 11 2413.3C1S, CD40LG, CD55, HP, SERPING1
21polysaccharide4510.3CD40LG, CD55, CD52, HP
22rituximab45 50 1112.3HP, CD52, CD55, CD59, CD40LG, DSG1
23fructose-1,6-bisphosphate4510.3HPR, G6PD
24alanine4510.3GYPA, CD40LG, CD55, HP, HPR, SERPING1
25tuberculin4510.2CD40LG, HP
26estrogen4510.2G6PD, CD40LG, CD55, HP, HPR, IL17A
27lipid4510.1G6PD, WRB, GYPA, CD59, CD55, HP
28glucose4510.0G6PD, CD59, CD55, HP, HPR, SIRPA
29atorvastatin45 50 29 11 2414.0CD55, CD59, CD40LG

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.2LAG3, IL17A, CD40LG, GYPA

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory burstGO:04573010.3CD52, CD55
2complement activation, classical pathwayGO:0069589.9SERPING1, CD55, C1S

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.3HPR, HP

Products for genes affiliated with Autoimmune Hemolytic Anemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Hemolytic Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet