MCID: ATM010
MIFTS: 57

Autoimmune Hemolytic Anemia malady

Immune diseases, Genetic diseases categories

Summaries for Autoimmune Hemolytic Anemia

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Autoimmune hemolytic anemia (aiha) occurs when your immune system makes antibodies that attack your red blood cells. this causes a drop in the number of red blood cells, leading to hemolytic anemia. symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. aiha can be primary (idiopathic) or result from an underlying disease or medication. the condition may develop gradually or occur suddenly. there are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. last updated: 12/19/2012

MalaCards: Autoimmune Hemolytic Anemia, also known as idiopathic autoimmune hemolytic anemia, is related to hemolytic anemia and leukemia. An important gene associated with Autoimmune Hemolytic Anemia is HP (haptoglobin), and among its related pathways are Classical antibody-mediated complement activation and Hematopoietic cell lineage. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds sulfasalazine and anaphylatoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Disease Ontology:8 An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

Wikipedia:63 Autoimmune hemolytic anemia (or autoimmune haemolytic anaemia; AIHA) occurs when antibodies directed... more...

Description from OMIM:46 205700

Aliases & Classifications for Autoimmune Hemolytic Anemia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Immune diseases


Aliases & Descriptions:

autoimmune hemolytic anemia 8 42 10 44 60
idiopathic autoimmune hemolytic anemia 42
familial auto-immune hemolytic anemia 42
acquired autoimmune hemolytic anemia 42
autoimmune hemolytic anemia nos 8
autoimmune haemolytic anaemias 8
autoimmune haemolytic anaemia 8
autoimmune hemolytic anemias 8
anemia hemolytic autoimmune 42
immuno-hemolytic anemia 42


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Disease Ontology8 DOID:718
NCIt39 C34378
ICD9CM27 283.0
MeSH34 D000744
OMIM46 205700

Related Diseases for Autoimmune Hemolytic Anemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hemolytic Anemia family:

autoimmune hemolytic anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Autoimmune Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic anemia32.2PIGA, CD59, G6PD, HP, CD55
2leukemia31.4PIGA, SIRPA, IL17A, CD59, CD52, GYPA
3hepatitis31.4HP, CD40LG
4chronic lymphocytic leukemia31.3CD55, CD52, CD59, CD40LG
5thrombocytopenia31.1HP, PIGA, CD40LG, HPR
6hepatitis c31.0CD40LG, HP
7deficiency anemia31.0CD55, CD59, HP, HPR, PIGA, G6PD
8lupus erythematosus30.9C1S, CD40LG
9systemic lupus erythematosus30.9IL17A, CD55, CD59, CD40LG, C1S
10acute leukemia30.8IL17A
11glomerulonephritis30.7CD55, CD59, CD40LG
12non-hodgkin lymphoma30.6C1S, CD52, CD59, CD55
13hereditary spherocytosis30.6G6PD, GYPA
14pneumonia30.5IL17A, GYPA
15pancreatitis30.4C1S
16sickle cell anemia30.4HP, G6PD
17hemoglobinuria30.4CD59, CD55, HP, PIGA, G6PD
18arthritis30.4CD59, IL17A, HPR, CD55, HP
19pancytopenia30.2CD55, HP
20connective tissue disease30.2CD40LG, C1S
21congenital hemolytic anemia30.2HP, G6PD
22psoriasis30.2CD55, IL17A, CD59
23malaria30.2HP, GYPA, G6PD, HPR
24multiple sclerosis30.2CD59, CD55, CD52, IL17A
25pancreatic cancer30.2SIRPA, HP, CD59, CD55
26chronic myeloid leukemia30.2SIRPA, CD55, CD59, G6PD
27ovarian cancer30.2IL17A, HPR, HP, CD59
28rheumatoid arthritis30.2CD40LG, CD59, CD55, CD52, HP, C1S
29diabetes mellitus30.2HPR, HP, CD40LG, G6PD
30autoimmune hepatitis10.9
31hepatitis a10.7
32pure red-cell aplasia10.7
33autoimmune thrombocytopenic purpura10.7
34purpura10.7
35primary biliary cirrhosis10.6
36antiphospholipid syndrome10.5
37ulcerative colitis10.5
38evans' syndrome10.5
39common variable immunodeficiency10.5
40hodgkin's lymphoma10.5
41crohn's disease10.4
42macroglobulinemia10.4
43splenic infarction10.4
44diffuse large b-cell lymphoma10.4
45warm antibody hemolytic anemia10.4
46drug-induced autoimmune hemolytic anemia10.4
47autoimmune thyroiditis10.4
48hemophagocytic lymphohistiocytosis10.4
49hepatitis e10.4
50splenic marginal zone lymphoma10.4

Graphical network of the top 20 diseases related to Autoimmune Hemolytic Anemia:



Diseases related to autoimmune hemolytic anemia

Clinical Features for Autoimmune Hemolytic Anemia

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46OMIM
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Clinical features from OMIM:

205700

Drugs & Therapeutics for Autoimmune Hemolytic Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hemolytic Anemia

Search NIH Clinical Center for Autoimmune Hemolytic Anemia

Search CenterWatch for Autoimmune Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Autoimmune Hemolytic Anemia

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Anatomical Context for Autoimmune Hemolytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Hemolytic Anemia:

32
Testes, T cells, B cells, Liver, Bone marrow, Bone, Thyroid, Kidney, Heart, Nk cells, Monocytes, Myeloid, Brain, Colon, Pancreas

Animal Models for Autoimmune Hemolytic Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.0CD40LG, CD59, CD55, HP, IL17A, T
2MP:00053979.5LAG3, G6PD, PIGA, CD40LG, CD59, CD55

Publications for Autoimmune Hemolytic Anemia

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50PubMed
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Articles related to Autoimmune Hemolytic Anemia:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Rare coexistence of Rosai-Dorfman disease and nodal marginal zone lymphoma complicated by severe life-threatening autoimmune hemolytic anemia. (23270580)
2013
2
Neutrophil-erythrocyte rosettes in autoimmune hemolytic anemia. (22886729)
2013
3
Sustained response to low-dose rituximab in idiopathic autoimmune hemolytic anemia. (24033754)
2013
4
An infant with acute brucellosis presenting with coombs-positive autoimmune hemolytic anemia: is breastfeeding guilty for transmission? (23560724)
2013
5
MicroRNA expression in chronic lymphocytic leukemia developing autoimmune hemolytic anemia. (23286334)
2013
6
A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. (22450906)
2012
7
Successful treatment of autoimmune hemolytic anemia associated with multicentric Castleman disease by anti-interleukin-6 receptor antibody (tocilizumab) therapy. (21757886)
2011
8
Direct antiglobulin test-negative autoimmune hemolytic anemia associated with HLA-haploidentical stem cell transplantation. (21472396)
2011
9
Autoimmune hemolytic anemia associated with ulcerative colitis: the most important step is to induce complete remission. (20445515)
2010
10
Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice. (20079426)
2010
11
Autoimmune hemolytic anemia associated with a formulation of traditional Chinese medicines. (19767374)
2009
12
Pure red cell aplasia accompanied by autoimmune hemolytic anemia in a patient with type A viral hepatitis. (19483404)
2009
13
Severe autoimmune hemolytic anemia in a liver transplanted child. (18433411)
2008
14
Coomb's negative autoimmune hemolytic anemia: a diagnostic dilemma for the hematologist. (19008606)
2008
15
Primary diffuse large B-cell lymphoma of the bone marrow complicated with autoimmune hemolytic anemia and erythroid hypoplasia]. (17695307)
2007
16
Complete remission of multiple myeloma after autoimmune hemolytic anemia: possible association with interferon-alpha. (17236186)
2007
17
Alemtuzumab for giant cell hepatitis with autoimmune hemolytic anemia. (18030239)
2007
18
Autoimmune hemolytic anemia following allogeneic hematopoietic stem cell transplantation in adult patients. (17351645)
2007
19
Development of mixed-type autoimmune hemolytic anemia and Evans' syndrome following chicken pox infection in a case of low-titer cold agglutinin disease. (17050195)
2006
20
Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia. (16677361)
2006
21
Early-onset autoimmune hemolytic anemia after cladribine therapy for WaldenstrAPm's macroglobulinemia. (16398735)
2006
22
Severe autoimmune hemolytic anemia in a patient with chronic hepatitis C during treatment with peginterferon alfa-2a and ribavirin. (16785129)
2006
23
Plasma exchanges do not increase red blood cell transfusion efficiency in severe autoimmune hemolytic anemia: a retrospective case-control study. (16607631)
2006
24
Lenalidomide-induced warm autoimmune hemolytic anemia. (17158529)
2006
25
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
26
Coombs-positive autoimmune hemolytic anemia in Crohn's disease. (15879729)
2005
27
Multiple myeloma complicated by autoimmune hemolytic anemia. (15335188)
2004
28
Autoimmune hemolytic anemia with giant cell hepatitis: case report and review of the literature. (15591908)
2004
29
A case of atrial septal defect complicated by autoimmune hemolytic anemia. (15209556)
2004
30
Mechanisms of immunological tolerance loss versus erythrocyte self-antigens and autoimmune hemolytic anemia. (14563012)
2003
31
Autoimmune hemolytic anemia in a patient with acute myelocytic leukemia. (14508809)
2003
32
Concomitant anuric post-streptococcal glomerulonephritis and autoimmune hemolytic anemia. (12740696)
2003
33
Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. (12531800)
2003
34
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
35
Long lasting myelodysplastic syndrome complicated by autoimmune hemolytic anemia and non-Hodgkin's lymphoma. (11982620)
2002
36
Transfusion support with RBCs from an Mk homozygote in a case of autoimmune hemolytic anemia following diphtheria-pertussis-tetanus vaccination. (12084164)
2002
37
Mixed warm and cold autoimmune hemolytic anemia: complete recovery after 2 courses of rituximab treatment. (12001903)
2002
38
Intracardiac thrombus in a patient with autoimmune hemolytic anemia leading to a diagnosis of antiphospholipid syndrome. (11978938)
2002
39
Giant cell hepatitis with autoimmune hemolytic anemia and hemophagocytosis. (11345187)
2001
40
Autoimmune hemolytic anemia in treatment-naA^ve chronic hepatitis C infection. (11246355)
2001
41
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. (10587359)
1999
42
A persistent severe autoimmune hemolytic anemia despite apparent direct antiglobulin test negativization. (10553166)
1999
43
Mixed-type autoimmune hemolytic anemia following fludarabine treatment in a patient with chronic lymphocytic leukemia/small cell lymphoma. (9501412)
1998
44
Autoimmune hemolytic anemia and HLA-DQ6. (9754814)
1998
45
High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia. (9267883)
1997
46
Hypofibrinogenemia induced by prednisolone therapy in a patient with chronic lymphocytic leukemia complicated with autoimmune hemolytic anemia. (9256301)
1997
47
Autoimmune hemolytic anemia in multicentric Castleman's disease. (8900850)
1996
48
Characterization of autoantibodies in mixed-type autoimmune hemolytic anemia. (1905082)
1991
49
Autoimmune hemolytic anemia in Gaucher's disease. (2319738)
1990
50
Splenectomy for pure red-cell hypoplastic (aregenerative) anemia associated with autoimmune hemolytic disease; report of a case. (13214388)
1954

Genetic Variations for Autoimmune Hemolytic Anemia

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Expression for genes affiliated with Autoimmune Hemolytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Hemolytic Anemia

Search GEO for disease gene expression data for Autoimmune Hemolytic Anemia.

Pathways for genes affiliated with Autoimmune Hemolytic Anemia

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53Reactome, 29KEGG, 51QIAGEN, 55SinoBiological, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Autoimmune Hemolytic Anemia

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1sulfasalazine44 28 49 1113.6G6PD, CD40LG, HP
2anaphylatoxin4410.6HP, CD55, CD59
3alemtuzumab44 1111.6CD52, CD40LG, PIGA
4glycolipid4410.6CD55, CD59, GYPA
5ribavirin44 49 1112.6G6PD, CD40LG, HP
6thiobarbituric acid4410.5HP, G6PD
7fludarabine44 1111.5CD40LG, CD55, CD52
8lactose44 1111.5G6PD, CD40LG, HP, HPR
9vitamin b124410.5HP, CD40LG, G6PD
1023-diphosphoglycerate4410.5HP, G6PD
11aspirin44 49 28 2413.5C1S, G6PD, CD40LG, CD59, HP
12sucrose44 11 2412.5HP, CD55, CD59, DSG1
13sialic acid4410.5GYPA, CD59, CD55, CD52, HP
14actinomycin d4410.5IL17A, HP, CD55, CD40LG, G6PD
15cyclosporin a44 28 5912.4CD40LG, CD59, CD55, HP, IL17A
16creatinine4410.4G6PD, CD40LG, CD55, HP, IL17A
17polyethylene glycol4410.4HP, CD40LG, G6PD
18zinc protoporphyrin4410.3HP, G6PD
19serine4410.3G6PD, DSG1, CD55, HP, HPR, SERPING1
20heparin44 28 11 2413.3C1S, CD40LG, CD55, HP, SERPING1
21polysaccharide4410.3CD40LG, CD55, CD52, HP
22rituximab44 49 1112.3HP, CD52, CD55, CD59, CD40LG, DSG1
23fructose-1,6-bisphosphate4410.3HPR, G6PD
24alanine4410.3GYPA, CD40LG, CD55, HP, HPR, SERPING1
25tuberculin4410.2CD40LG, HP
26estrogen4410.2G6PD, CD40LG, CD55, HP, HPR, IL17A
27lipid4410.1G6PD, WRB, GYPA, CD59, CD55, HP
28glucose4410.0G6PD, CD59, CD55, HP, HPR, SIRPA
29atorvastatin44 49 28 11 2414.0CD55, CD59, CD40LG

GO Terms for genes affiliated with Autoimmune Hemolytic Anemia

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16Gene Ontology
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Cellular components related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.2LAG3, IL17A, CD40LG, GYPA

Biological processes related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1respiratory burstGO:04573010.3CD52, CD55
2complement activation, classical pathwayGO:0069589.9SERPING1, CD55, C1S

Molecular functions related to Autoimmune Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049210.3HPR, HP

Products for genes affiliated with Autoimmune Hemolytic Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet