MCID: ATM011
MIFTS: 51

Autoimmune Hepatitis malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Liver diseases, Infectious diseases categories

Aliases & Classifications for Autoimmune Hepatitis

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 47Orphanet, 60UMLS, 43Novoseek, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Autoimmune Hepatitis, Aliases & Descriptions:

Name: Autoimmune Hepatitis 30 9 41 11 47
Autoimmune Hepatitis with Centrilobular Necrosis 9 60
Autoimmune Chronic Active Hepatitis 9
Chronic Autoimmune Hepatitis 47
 
Autoimmune Chronic Hepatitis 41
Hepatitis, Autoimmune 60
Hepatitis Autoimmune 43
Aih 41


Classifications:

Orphanet: 47 
Rare hepatic diseases


Characteristics (Orphanet epidemiological data):

47
autoimmune hepatitis:
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult


External Ids:

Disease Ontology9 DOID:2048
ICD9CM27 571.42
NCIt38 C27029
MeSH33 D019693
Orphanet47 2137
ICD10 via Orphanet26 K75.4
UMLS via Orphanet61 C0241910
ICD1025 K75.4

Summaries for Autoimmune Hepatitis

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NIH Rare Diseases:41 Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. this immune response causes inflammation of the liver, also called hepatitis. the disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. autoimmune hepatitis sometimes occurs in relatives of people with autoimmune diseases, suggesting a genetic cause. this disease is most common in young girls and women. last updated: 6/8/2011

MalaCards based summary: Autoimmune Hepatitis, also known as autoimmune hepatitis with centrilobular necrosis, is related to hepatitis and primary biliary cirrhosis. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are One carbon pool by folate and Metabolism. The compounds perhexiline and thiopurine have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and testes, and related mouse phenotypes are liver/biliary system and normal.

Disease Ontology:9 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia:63 Autoimmune Hepatitis, formerly called lupoid hepatitis, is a chronic disease of the liver that occurs... more...

Related Diseases for Autoimmune Hepatitis

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Diseases in the Hepatitis family:

Hepatitis C Virus autoimmune hepatitis
Hepatitis B Hepatitis C
Hepatitis D Hepatitis a
Hepatitis E Viral Hepatitis

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.2ARG1, SEPSECS
2primary biliary cirrhosis31.5AIRE, SEPSECS, CTLA4
3thyroiditis31.4CTLA4
4lupus erythematosus31.1C4A
5systemic lupus erythematosus31.1C4A
6thymoma30.5AIRE, CTLA4
7vasculitis30.4CTLA4, TPMT
8hashimoto thyroiditis30.4CTLA4, AIRE
9rheumatoid arthritis30.3TNFRSF6B, TPMT, FCRL3, CTLA4
10myasthenia gravis30.2CTLA4, AIRE
11graves' disease30.2CTLA4, FCRL3, AIRE
12addison's disease30.1AIRE, CYP2D6, CTLA4
13hepatitis a10.7
14cholangitis10.7
15sclerosing cholangitis10.6
16hepatitis c10.6
17hepatocellular carcinoma10.5
18celiac disease10.5
19liver disease10.5
20connective tissue disease10.4
21arthritis10.4
22mixed connective tissue disease10.4
23colitis10.4
24alopecia areata10.4AIRE
25ulcerative colitis10.4
26hepatitis c virus10.3
27acute liver failure10.3
28crohn's disease10.3
29hemolytic anemia10.3
30hepatitis b10.3
31adult-onset still's disease10.3
32purpura10.3
33polymyositis10.3
34wegener granulomatosis10.3TPMT, CTLA4
35autoimmune thyroiditis10.3
36autoimmune hemolytic anemia10.3
37viral hepatitis10.3
38inflammatory bowel disease10.3
39graft-versus-host disease, protection against10.3CTLA4, SEPSECS
40hypoparathyroidism10.2CTLA4, AIRE
41rheumatic disease10.2TPMT, CTLA4
42liver cirrhosis10.2
43thrombocytopenia10.2
44polyarteritis nodosa10.2
45pyoderma gangrenosum10.2
46visceral leishmaniasis10.2
47autoimmune polyendocrine syndrome10.2
48leishmaniasis10.2
49pyoderma10.2
50vitiligo-associated multiple autoimmune disease susceptibility 110.2CTLA4, AIRE

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to autoimmune hepatitis

Symptoms for Autoimmune Hepatitis

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Drugs & Therapeutics for Autoimmune Hepatitis

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Hepatitis

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Genetic Tests for Autoimmune Hepatitis

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Anatomical Context for Autoimmune Hepatitis

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MalaCards organs/tissues related to Autoimmune Hepatitis:

31
Liver, Testes, T cells, Thyroid, Bone marrow, Bone, Kidney, Pancreas, Smooth muscle, B cells, Neutrophil, Lymph node, Spleen, Heart, Skin, Myeloid

FMA organs/tissues related to Autoimmune Hepatitis:

14
Liver

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autoimmune Hepatitis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Hepatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7ARG1, CTLA4, ASIP, AIRE
2MP:00028737.9AIRE, PTPRCAP, ASIP, CTLA4, ARG1
3MP:00053977.8ARG1, CTLA4, ASIP, TPMT, PTPRCAP, AIRE

Publications for Autoimmune Hepatitis

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Articles related to Autoimmune Hepatitis:

(show top 50)    (show all 821)
idTitleAuthorsYear
1
Review article: the prevention and reversal of hepatic fibrosis in autoimmune hepatitis. (24387318)
2014
2
Anti-SLA/LP alone or in combination with anti-Ro52 and fine specificity of anti-Ro52 antibodies in patients with autoimmune hepatitis. (25113420)
2014
3
Regulatory T cells and autoimmune hepatitis: What happens in the liver stays in the liver. (25131772)
2014
4
Fetal intestinal perforation and meconium peritonitis associated with maternal autoimmune hepatitis. (24815708)
2014
5
Cytomegalovirus infection simulating an overlap syndrome: Autoimmune hepatitis -primary biliary cirrhosis. (25860689)
2014
6
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
7
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact? (23293207)
2013
8
Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis. (23178709)
2013
9
SPRi-Based Strategy to Identify Specific Biomarkers in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Autoimmune Hepatitis. (24376828)
2013
10
Autoimmune hepatitis on the rise. (24295874)
2013
11
Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: a nationwide, multicenter study. (23033899)
2013
12
Drug choices in autoimmune hepatitis: part A--Steroids. (23061711)
2012
13
Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence. (22345339)
2012
14
The CYP2D6 animal model: how to induce autoimmune hepatitis in mice. (22331063)
2012
15
Role of thiopurine metabolite measurement in the management of autoimmune hepatitis. (22589202)
2012
16
Clinical features and long term outcome of 102 treated autoimmune hepatitis patients. (22509185)
2012
17
Histopathology of de novo autoimmune hepatitis. (22378542)
2012
18
Hepatitis surface antigen clearance in a woman with liver cirrhosis and concomitant autoimmune hepatitis under immunosuppressive therapy. (23181542)
2012
19
Diagnosis and treatment of autoimmune hepatitis. (22179843)
2012
20
Autoimmune hepatitis in children: an overview of the disease focusing on current therapies. (22495399)
2012
21
Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population. (20977921)
2011
22
Optimizing management in autoimmune hepatitis with liver failure at initial presentation. (21547124)
2011
23
Advanced histology and impaired liver regeneration are associated with disease severity in acute-onset autoimmune hepatitis. (21401703)
2011
24
The benefit of animal models for autoimmune hepatitis. (22117631)
2011
25
Mycophenolate mofetil as a rescue therapy for autoimmune hepatitis patients who are not responsive to standard therapy. (21780898)
2011
26
Requirements and challenges of a preclinical autoimmune hepatitis mouse model. (21894011)
2011
27
Performance of the international classifications criteria for autoimmune hepatitis diagnosis in Mexican patients. (21875376)
2011
28
Seven cases of autoimmune hepatitis that developed after drug-induced liver injury. (21725992)
2011
29
Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus: review of literature. (21885954)
2011
30
Risk factors associated with relapse of type 1 autoimmune hepatitis in Japan. (21711423)
2011
31
Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl. (21596082)
2011
32
Another cause of autoimmune hepatitis. (20578154)
2010
33
Corticosteroid-induced mania in a patient with autoimmune hepatitis. (20220360)
2010
34
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
35
Clinical features of 107 autoimmune hepatitis patients and 30 of them with AIH-primary biliary cirrhosis overlap syndrome]. (18510851)
2008
36
Effects of serum aspartate aminotransferase levels in patients with autoimmune hepatitis influence disease course and outcome. (18840547)
2008
37
Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. (18200656)
2008
38
A functional Fas promoter polymorphism is associated with a severe phenotype in type 1 autoimmune hepatitis characterized by early development of cirrhosis. (17493146)
2007
39
Selenocysteine, soluble liver antigen/liver-pancreas, and autoimmune hepatitis. (17596869)
2007
40
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. (16876902)
2006
41
Scleroderma-like lesions in the course of autoimmune hepatitis. Case report]. (16334539)
2005
42
Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis. (16428159)
2005
43
Secondary IgA nephropathy presenting as nephrotic syndrome with glomerular crescentic changes and acute renal failure in a patient with autoimmune hepatitis. (15151269)
2004
44
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
45
HLA genotyping in type-I autoimmune hepatitis in Western India. (14719586)
2003
46
Anti-cytokeratin antibodies in sera of the patients with autoimmune hepatitis. (11529922)
2001
47
Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1. (11343230)
2001
48
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
49
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. (11092254)
2000
50
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999

Variations for Autoimmune Hepatitis

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Expression for genes affiliated with Autoimmune Hepatitis

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Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for genes affiliated with Autoimmune Hepatitis

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Pathways related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.8FTCD, TPMT
2
Show member pathways
8.4ARG1, FTCD, TPMT, TNFRSF6B, CYP2D6

Compounds for genes affiliated with Autoimmune Hepatitis

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Compounds related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 12)
idCompoundScoreTop Affiliating Genes
1perhexiline43 1211.0CYP2D6, TPMT
2thiopurine4310.0TPMT, CYP2D6
3halothane43 49 28 1213.0SEPSECS, CYP2D6
4Pyridoxal 5'-phosphate2410.0FTCD, SEPSECS
5uridine diphosphate4310.0TPMT, CYP2D6
6bortezomib43 49 1211.9CTLA4, CYP2D6
7mycophenolate mofetil43 49 1211.8CTLA4, SEPSECS, TPMT
8xanthine43 2410.7TPMT, CYP2D6
9isoleucine439.5CYP2D6, ARG1
10cyclosporin a43 28 5911.3CTLA4, SEPSECS, TPMT
11tyrosine438.7AIRE, CYP2D6, PTPRCAP, TPMT, CTLA4
12steroid438.7C4A, CTLA4, SEPSECS, TPMT, CYP2D6

GO Terms for genes affiliated with Autoimmune Hepatitis

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Products for genes affiliated with Autoimmune Hepatitis

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Sources for Autoimmune Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet