MCID: ATM011
MIFTS: 63

Autoimmune Hepatitis

Categories: Rare diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Autoimmune Hepatitis

MalaCards integrated aliases for Autoimmune Hepatitis:

Name: Autoimmune Hepatitis 37 12 72 49 55 36 14
Hepatitis, Autoimmune 41 69
Autoimmune Hepatitis with Centrilobular Necrosis 12
Autoimmune Chronic Active Hepatitis 12
Autoimmune Chronic Hepatitis 49
Chronic Autoimmune Hepatitis 55
Hepatitis Autoimmune 51
Aih 49

Characteristics:

Orphanet epidemiological data:

55
autoimmune hepatitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Norway),1-5/10000 (Norway),1-9/1000000 (Sweden),1-5/10000 (New Zealand),1-9/1000000 (Spain),1-5/10000 (Spain),1-5/10000 (Sweden),1-9/1000000 (Israel),1-5/10000 (Israel),1-9/100000 (Denmark),1-5/10000 (Denmark),1-9/100000 (Singapore),1-9/100000; Age of onset: Adult;

Classifications:

Orphanet: 55  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:2048
ICD10 32 K75.4
ICD9CM 34 571.42
MeSH 41 D019693
Orphanet 55 ORPHA2137
UMLS via Orphanet 70 C0241910
ICD10 via Orphanet 33 K75.4
KEGG 36 H01685

Summaries for Autoimmune Hepatitis

NIH Rare Diseases : 49 Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. This immune response causes inflammation of the liver, also called hepatitis. The disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. Autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. It occurs more frequently in females. Treatment typically includes corticosteroids and medications that suppress the immune system. In severe cases, a liver transplant may be needed. Last updated: 10/1/2016

MalaCards based summary : Autoimmune Hepatitis, also known as hepatitis, autoimmune, is related to hepatitis and autoimmune pancreatitis. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include Blood and Umbilical Cord, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that results_in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia : 72 Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver... more...

Related Diseases for Autoimmune Hepatitis

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.6 F2 GGT1 GPT SEPSECS
2 autoimmune pancreatitis 30.1 CTLA4 HLA-DQB1 HLA-DRB1
3 celiac disease 1 30.0 CD40LG CTLA4 HLA-A HLA-DQB1
4 hepatitis b 29.9 CTLA4 F2 GGT1 GPT
5 hashimoto thyroiditis 29.9 AIRE CTLA4 FAS
6 hepatitis e 29.8 CD40LG F2 GPT
7 liver cirrhosis 29.6 F2 GGT1 GPT KRT8
8 cholestasis 29.4 F2 GGT1 GPT
9 cholangitis 29.0 CD40LG DLAT F2 GGT1 GPT HLA-DRB1
10 cholangitis, primary sclerosing 29.0 AIRE DLAT GGT1 GPT HLA-A SEPSECS
11 diabetes mellitus 28.9 AIRE CTLA4 HLA-DQB1 HLA-DRB1
12 viral hepatitis 28.9 CD40LG F2 FAS GGT1 GPT SEPSECS
13 primary biliary cirrhosis 28.8 CD40LG CTLA4 DLAT F2 GGT1 GPT
14 systemic lupus erythematosus 28.7 CD40LG CTLA4 F2 FAS HLA-DQB1 HLA-DRB1
15 liver disease 28.5 DLAT F2 FAS GGT1 GPT KRT8
16 autoimmune disease 28.2 AIRE CD40LG CTLA4 FAS HLA-DQB1 HLA-DRB1
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 11.0
18 amelogenesis imperfecta hypomaturation type 10.9
19 limbic encephalitis with lgi1 antibodies 10.6 HLA-DQB1 HLA-DRB1
20 type 1 diabetes mellitus 12 10.5 CTLA4 HLA-DRB1
21 postherpetic neuralgia 10.5 HLA-A HLA-DRB1
22 metal allergy 10.5 HLA-DQB1 HLA-DRB1
23 focal epithelial hyperplasia 10.5 HLA-DQB1 HLA-DRB1
24 beryllium disease 10.5 HLA-DQB1 HLA-DRB1
25 lichen planopilaris 10.5 HLA-DQB1 HLA-DRB1
26 hepatoportal sclerosis 10.5 F2 GPT
27 idiopathic inflammatory myopathy 10.5 HLA-DQB1 HLA-DRB1
28 recurrent respiratory papillomatosis 10.5 HLA-DQB1 HLA-DRB1
29 biliary cirrhosis, primary, 1 10.4
30 chronic beryllium disease 10.4 HLA-DQB1 HLA-DRB1
31 pars planitis 10.4 HLA-A HLA-DRB1
32 anca-associated vasculitis 10.4 CTLA4 HLA-DRB1
33 caplan's syndrome 10.4 FAS HLA-A
34 amelogenesis imperfecta, type ie 10.4 CYP2D6 FTCD SEPSECS
35 pityriasis rosea 10.4 HLA-A HLA-DQB1 HLA-DRB1
36 idiopathic bronchiectasis 10.4 HLA-A HLA-DQB1 HLA-DRB1
37 geographic tongue 10.3 HLA-A HLA-DQB1 HLA-DRB1
38 qualitative platelet defect 10.3 F2 HLA-A
39 paraneoplastic pemphigus 10.3 HLA-A HLA-DQB1 HLA-DRB1
40 kwashiorkor 10.3 F2 GPT
41 lichen sclerosus 10.3 HLA-DQB1 HLA-DRB1
42 type 1 diabetes mellitus 17 10.3 AIRE CTLA4
43 hypersomnia 10.3 CYP2D6 HLA-DQB1 HLA-DRB1
44 type ii mixed cryoglobulinemia 10.3 FAS HLA-DQB1 HLA-DRB1
45 prostate squamous cell carcinoma 10.3 HLA-A KRT8
46 hepatitis a 10.3
47 autoimmune addison disease 10.3 AIRE CTLA4 HLA-DRB1
48 whipple disease 10.3 HLA-DQB1 HLA-DRB1
49 hepatic tuberculosis 10.2 F2 GGT1 GPT
50 fournier gangrene 10.2 CD40LG F2

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to Autoimmune Hepatitis

Symptoms & Phenotypes for Autoimmune Hepatitis

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 GGT1 AIRE CD40LG HLA-DQB1 KRT8 CTLA4
2 homeostasis/metabolism MP:0005376 10 FAS GGT1 AIRE CD40LG HLA-DQB1 KRT8
3 endocrine/exocrine gland MP:0005379 9.97 FAS GGT1 AIRE CD40LG HLA-DQB1 CTLA4
4 liver/biliary system MP:0005370 9.7 AIRE HLA-DQB1 CTLA4 KRT8 PDCD1 CYP1A2
5 reproductive system MP:0005389 9.56 FAS GGT1 AIRE CD40LG HLA-DQB1 KRT8
6 respiratory system MP:0005388 9.17 AIRE HLA-DQB1 CTLA4 PDCD1 CYP1A2 F2

Drugs & Therapeutics for Autoimmune Hepatitis

Drugs for Autoimmune Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
4
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
5
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
6
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
7
Mycophenolic acid Approved Phase 4 24280-93-1 446541
8 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
9 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3
11 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
13 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
14 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
15 glucocorticoids Phase 4,Phase 3,Phase 2
16 Hormone Antagonists Phase 4,Phase 3,Phase 2
17 Hormones Phase 4,Phase 3,Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
19 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Methylprednisolone acetate Phase 4,Phase 3
22 Methylprednisolone Hemisuccinate Phase 4,Phase 3
23 Prednisolone acetate Phase 4,Phase 3
24 Prednisolone hemisuccinate Phase 4,Phase 3
25 Prednisolone phosphate Phase 4,Phase 3
26 Anthelmintics Phase 4
27 Antimalarials Phase 4
28 Antimetabolites Phase 4,Phase 2
29 Antimetabolites, Antineoplastic Phase 4,Phase 2
30 Antiparasitic Agents Phase 4
31 Antiprotozoal Agents Phase 4
32 Chloroquine diphosphate Phase 4 50-63-5
33 Anti-Bacterial Agents Phase 4
34 Antibiotics, Antitubercular Phase 4
35 Antitubercular Agents Phase 4
36
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
37
Budesonide Approved Phase 2, Phase 3 51333-22-3 5281004 63006
38 Antiemetics Phase 3
39 Antifungal Agents Phase 3
40 Autonomic Agents Phase 3,Phase 2
41 Calcineurin Inhibitors Phase 3,Phase 2
42 Cyclosporins Phase 3
43 Dermatologic Agents Phase 3
44 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
45 Neuroprotective Agents Phase 3
46 Protective Agents Phase 3
47 Anti-Asthmatic Agents Phase 2, Phase 3
48 Bronchodilator Agents Phase 2, Phase 3
49 Respiratory System Agents Phase 2, Phase 3
50
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0

Interventional clinical trials:

(show all 36)

# Name Status NCT ID Phase Drugs
1 Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial Completed NCT02463331 Phase 4 Chloroquine diphosphate;prednisone;azathioprine
2 CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS Completed NCT01980745 Phase 4 Chloroquine diphosphate 250mg;Placebo
3 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4 Treatment with mycophenolat mofetil;Treatment with azathioprin
4 Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis Recruiting NCT02900443 Phase 4 Mycophenolate mofetil;Azathioprine
5 Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis Unknown status NCT01170351 Phase 3 Cyclosporine-A
6 Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis Completed NCT00838214 Phase 2, Phase 3 budesonide;prednisone
7 ADCC Mediated B-Cell dEpletion and BAFF-R Blockade Not yet recruiting NCT03217422 Phase 2, Phase 3
8 Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis Withdrawn NCT02878863 Phase 3 Paeoniflorin + phosphatidylcholine or silymarin;Phosphatidylcholine or silymarin
9 Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis Unknown status NCT01661842 Phase 1, Phase 2
10 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
11 LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis Completed NCT00608894 Phase 2 LCP-Tacro (tacrolimus);Azathioprine
12 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Completed NCT01548690 Phase 2 Ornithine phenylacetate
13 Liver Test Study of Using JKB-122 in AIH Patients Recruiting NCT02556372 Phase 2 JKB-122
14 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
15 Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis Not yet recruiting NCT02704338 Phase 1, Phase 2
16 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Not yet recruiting NCT02997878 Phase 1, Phase 2
17 sPIF CLINICAL STUDY PROTOCOL FOR AUTOIMMUNE HEPATITIS Completed NCT02239562 Phase 1 sPIF;Placebo
18 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1 ursodeoxycholic acid (UDCA)
19 Autoimmune Hepatitis Study Terminated NCT00286663 Phase 1
20 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
21 Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis Unknown status NCT00160940
22 Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis Completed NCT01655121
23 Transient Elastography in Autoimmune Hepatitis Completed NCT01905254
24 "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children" Completed NCT03069976 Metronidazole
25 De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Recruiting NCT02056054
26 Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis Recruiting NCT02950077
27 Study of the Clinical Features of Autoimmune Hepatitis Recruiting NCT02994537
28 The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis Recruiting NCT02050646
29 Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Recruiting NCT02936596 Ursodeoxycholic acid combination of immunosuppressive agents;Ursodeoxycholic Acid
30 Plasma Exchange Combination of Immunosuppressive Regimens for Auto-immune Hepatitis Recruiting NCT02874586
31 Swiss Autoimmune Hepatitis Cohort Study Recruiting NCT03146884
32 MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Recruiting NCT03175471
33 MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Recruiting NCT03178630
34 Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI Recruiting NCT03198104
35 The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis Recruiting NCT02461979
36 Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis Withdrawn NCT00587119 Budesonide

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: hepatitis, autoimmune

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Hepatitis:

18
Liver

MalaCards organs/tissues related to Autoimmune Hepatitis:

38
Liver, T Cells, Testes, Bone, Thyroid, B Cells, Bone Marrow
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Autoimmune Hepatitis

Articles related to Autoimmune Hepatitis:

(show top 50) (show all 984)
# Title Authors Year
1
Long-term observation of acute-onset autoimmune hepatitis presenting clinically and radiologically as acute hepatitis. ( 29450869 )
2018
2
Protective effects of Punica granatum (pomegranate) peel extract on concanavalin A-induced autoimmune hepatitis in mice. ( 29428670 )
2018
3
Autoimmune hepatitis as a complication of common variable immunodeficiency. ( 29368942 )
2018
4
Autoimmune Hepatitis in Children. ( 29446799 )
2018
5
Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1. ( 29396050 )
2018
6
Type 1 autoimmune hepatitis presenting with severe autoimmune neutropenia. ( 29333079 )
2018
7
Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis. ( 29349620 )
2018
8
Epigenetic changes and their implications in autoimmune hepatitis. ( 29383703 )
2018
9
Haploidentical stem cell transplantation cures autoimmune hepatitis and cerebrovascular disease in a patient with sickle cell disease. ( 29335630 )
2018
10
Two-step progression of varenicline-induced autoimmune hepatitis. ( 29383494 )
2018
11
Hepatotoxicity of immune checkpoint inhibitors: a histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury. ( 29403081 )
2018
12
Serum IL-17 level predicts inflammatory activity in patients with autoimmune hepatitis. ( 29363666 )
2018
13
Leveraging Social Networking Sites for an Autoimmune Hepatitis Genetic Repository: Pilot Study to Evaluate Feasibility. ( 29348111 )
2018
14
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. ( 29387758 )
2018
15
Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. ( 29380822 )
2018
16
Primary Biliary Cholangitis-A Autoimmune Hepatitis Overlap Syndrome. ( 29423670 )
2018
17
Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. ( 29336235 )
2018
18
Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis. ( 29352427 )
2018
19
Risk of malignancies in autoimmune hepatitis type 1 patients with a long-term follow-up in Japan. ( 28841782 )
2017
20
Course of hepatitis E infection in a patient with rheumatoid arthritis and autoimmune hepatitis: A case report. ( 29390558 )
2017
21
Methotrexate in the Treatment of Autoimmune Hepatitis. ( 28844782 )
2017
22
Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis. ( 29252180 )
2017
23
Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients. ( 28809732 )
2017
24
Management of Autoimmune Hepatitis in Pregnant Women. ( 28867984 )
2017
25
Serum microRNA profiles in patients with chronic hepatitis B, chronic hepatitis C, primary biliary cirrhosis, autoimmune hepatitis, nonalcoholic steatohepatitis, or drug-induced liver injury. ( 28823616 )
2017
26
Safety and Efficacy of 6-thioguanine as a Second-line Treatment for Autoimmune Hepatitis. ( 28782666 )
2017
27
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. ( 28491884 )
2017
28
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding. ( 29358858 )
2017
29
Influence of Liver Inflammation on Liver Stiffness Measurement in Patients with Autoimmune Hepatitis Evaluation by Combinational Elastography. ( 28056459 )
2017
30
rs10499194 polymorphism in the tumor necrosis factor-I+ inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population. ( 28448618 )
2017
31
Acute-on-chronic hepatitis. A case report of autoimmune hepatitis/primary sclerosing cholangitis/ulcerative colitis overlap syndrome in a 15-year-old patient. ( 28856287 )
2017
32
Population-based prevalence, incidence, and disease burden of autoimmune hepatitis in South Korea. ( 28771543 )
2017
33
Imaging of autoimmune hepatitis and overlap syndromes. ( 27999888 )
2017
34
Seropositivity and Titers of Anti-Smooth Muscle Actin Antibody Are Associated with Relapse of Type 1 Autoimmune Hepatitis. ( 28822993 )
2017
35
The therapeutic effects of Yongdamsagan-tang on autoimmune hepatitis models. ( 28763748 )
2017
36
Review article: next-generation transformative advances in the pathogenesis and management of autoimmune hepatitis. ( 28901565 )
2017
37
IgG4-related sclerosing cholangitis overlapping with autoimmune hepatitis: Report of a case. ( 28238541 )
2017
38
HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype. ( 29088299 )
2017
39
Polyparaneoplastic Manifestations of Malignant Thymoma: A Unique Case of Myasthenia, Autoimmune Hepatitis, Pure Red Cell Aplasia, and Keratoconjunctivitis Sicca. ( 28744421 )
2017
40
Histological improvement of liver fibrosis in well-treated patients with autoimmune hepatitis: A cohort study. ( 28834875 )
2017
41
Xanthoma Striatum Palmare in a Patient of Primary Biliary Cirrhosis with Autoimmune Hepatitis. ( 28566919 )
2017
42
Association of autoimmune hepatitis type 1 in a child with Evans syndrome. ( 28878866 )
2017
43
Autoimmune hepatitis and eosinophilic granulomatosis with polyangiitis: a rare association. ( 28108440 )
2017
44
CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-I^ production by CD4(+) T cells. ( 28065940 )
2017
45
Autoimmune Hepatitis - Primary Biliary Cirrhosis Overlap Syndrome. ( 28892963 )
2017
46
Autoimmune Hepatitis Associated with Immune Thrombocytopenic Purpura. ( 28090042 )
2017
47
New Presentation of Autoimmune Hepatitis with Erythema Multiforme. ( 29059460 )
2017
48
Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis. ( 28871464 )
2017
49
Autoimmune hepatitis in the setting of human immunodeficiency virus infection: A case series. ( 29359021 )
2017
50
Sodium butyrate ameliorates S100/FCA-induced autoimmune hepatitis through regulation of intestinal tight junction and toll-like receptor 4 signaling pathway. ( 28811235 )
2017

Variations for Autoimmune Hepatitis

Expression for Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for Autoimmune Hepatitis

Pathways related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 12.31 CD40LG CTLA4 FAS PDCD1
2
Show member pathways
12.17 CD40LG CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
3
Show member pathways
12.15 CD40LG CTLA4 FAS PDCD1
4
Show member pathways
12.09 CD40LG CTLA4 HLA-DQB1 HLA-DRB1
5
Show member pathways
11.69 HLA-DQB1 HLA-DRB1 PDCD1
6
Show member pathways
11.69 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
7 11.59 CTLA4 HLA-DQB1 HLA-DRB1
8 11.4 CTLA4 HLA-DQB1 HLA-DRB1
9 11.32 CD40LG CTLA4 PDCD1
10 11.26 CD40LG CTLA4 HLA-A HLA-DQB1 HLA-DRB1 PDCD1
11 11.2 CD40LG CTLA4 PDCD1

GO Terms for Autoimmune Hepatitis

Cellular components related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 F2 FAS FTCD GGT1 GPT HLA-A
2 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-DQB1 HLA-DRB1
3 MHC class II protein complex GO:0042613 9.32 HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-A HLA-DQB1 HLA-DRB1
5 external side of plasma membrane GO:0009897 9.02 CD40LG CTLA4 F2 HLA-DRB1 PDCD1

Biological processes related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.69 CYP1A2 CYP2D6 GGT1
2 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.52 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation GO:0019882 9.5 HLA-A HLA-DQB1 HLA-DRB1
5 immune response GO:0006955 9.5 AIRE CD40LG CTLA4 FAS HLA-A HLA-DQB1
6 oxidative demethylation GO:0070989 9.49 CYP1A2 CYP2D6
7 heterocycle metabolic process GO:0046483 9.46 CYP1A2 CYP2D6
8 drug catabolic process GO:0042737 9.43 CYP1A2 CYP2D6
9 monoterpenoid metabolic process GO:0016098 9.4 CYP1A2 CYP2D6
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
11 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.26 HLA-DQB1 HLA-DRB1
12 alkaloid metabolic process GO:0009820 9.16 CYP1A2 CYP2D6
13 T cell costimulation GO:0031295 9.02 CD40LG CTLA4 HLA-DQB1 HLA-DRB1 PDCD1

Molecular functions related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP1A2 CYP2D6
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-A HLA-DQB1 HLA-DRB1

Sources for Autoimmune Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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