AIH
MCID: ATM011
MIFTS: 60

Autoimmune Hepatitis (AIH) malady

Categories: Rare diseases, Gastrointestinal diseases, Liver diseases, Immune diseases, Genetic diseases, Skin diseases, Infectious diseases

Aliases & Classifications for Autoimmune Hepatitis

Aliases & Descriptions for Autoimmune Hepatitis:

Name: Autoimmune Hepatitis 38 12 50 56 14
Hepatitis, Autoimmune 42 69
Autoimmune Hepatitis with Centrilobular Necrosis 12
Autoimmune Chronic Active Hepatitis 12
Autoimmune Chronic Hepatitis 50
Chronic Autoimmune Hepatitis 56
Hepatitis Autoimmune 52
Aih 50

Characteristics:

Orphanet epidemiological data:

56
chronic autoimmune hepatitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Norway),1-5/10000 (Norway),1-9/1000000 (Sweden),1-5/10000 (New Zealand),1-9/1000000 (Spain),1-5/10000 (Spain),1-5/10000 (Sweden),1-9/1000000 (Israel),1-5/10000 (Israel),1-9/100000 (Denmark),1-5/10000 (Denmark),1-9/100000 (Singapore),1-9/100000; Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:2048
ICD10 33 K75.4
ICD9CM 35 571.42
MeSH 42 D019693
Orphanet 56 ORPHA2137
UMLS via Orphanet 70 C0241910
ICD10 via Orphanet 34 K75.4

Summaries for Autoimmune Hepatitis

NIH Rare Diseases : 50 autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. this immune response causes inflammation of the liver, also called hepatitis. the disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. it occurs more frequently in females. treatment typically includes corticosteroids and medications that suppress the immune system. in severe cases, a liver transplant may be needed. last updated: 10/1/2016

MalaCards based summary : Autoimmune Hepatitis, also known as hepatitis, autoimmune, is related to hepatitis and cryptococcosis. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Simvastatin and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include Blood and Umbilical Cord, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that results_in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia : 71 Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver... more...

Related Diseases for Autoimmune Hepatitis

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
id Related Disease Score Top Affiliating Genes
1 hepatitis 31.7 CTLA4 HLA-A HLA-DRB1
2 cryptococcosis 29.4 CD40LG HLA-DQB1 HLA-DRB1
3 amelogenesis imperfecta hypomaturation type 10.8
4 primary biliary cirrhosis 10.4
5 sacral nerve root cysts 10.3 HLA-A HLA-DRB1
6 celiac disease 3 10.3 CTLA4 HLA-DRB1
7 familial progressive hyperpigmentation 10.3 F2 GPT
8 apple allergy 10.3 HLA-DQB1 HLA-DRB1
9 non-amyloid monoclonal immunoglobulin deposition disease 10.3 FAS HLA-DRB1
10 hemoglobin d disease 10.3 HLA-DQB1 HLA-DRB1
11 autosomal dominant intermediate charcot-marie-tooth 10.3 CTLA4 HLA-DQB1 HLA-DRB1
12 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DQB1 HLA-DRB1
13 fetal hemoglobin quantitative trait locus 3 10.2 CYP2D6 FTCD SEPSECS
14 rete testis adenocarcinoma 10.2 HLA-A HLA-DQB1
15 learning disability 10.2 HLA-A HLA-DQB1 HLA-DRB1
16 immune deficiency, familial variable 10.2 HLA-DQB1 HLA-DRB1
17 bickerstaff brainstem encephalitis 10.2 HLA-A HLA-DQB1 HLA-DRB1
18 noonan-like syndrome with loose anagen hair 10.2 AIRE CTLA4
19 anaerobic meningitis 10.2 HLA-A HLA-DQB1 HLA-DRB1
20 folinic acid-responsive seizures 10.2 HLA-A HLA-DQB1 HLA-DRB1
21 lin-gettig syndrome 10.2 HLA-DQB1 HLA-DRB1
22 complement component 8 deficiency 10.2 AIRE CTLA4 HLA-DRB1
23 midline interhemispheric variant of holoprosencephaly 10.2 FAS HLA-DQB1 HLA-DRB1
24 ringed hair 10.2 GGT1 GPT
25 hepatitis a 10.2
26 cholangitis 10.2
27 periodontosis 10.2 AIRE CTLA4 HLA-A
28 choreatic disease 10.1 CD40LG HLA-DQB1 HLA-DRB1
29 low anorectal malformation 10.1 CTLA4 F2 HLA-DQB1 HLA-DRB1
30 pemphigus vulgaris, familial 10.1 CD40LG HLA-A HLA-DRB1
31 freiberg's disease 10.1 CD40LG F2
32 pseudohypoparathyroidism 10.1 CD40LG FAS HLA-DRB1
33 pneumoconiosis due to talc 10.1 FAS HLA-A
34 sclerosing cholangitis 10.1
35 hepatitis c 10.1
36 bile duct cystadenocarcinoma 10.1 F2 GGT1 GPT
37 anterior corneal pigmentation 10.1 FAS HLA-A HLA-DQB1 HLA-DRB1
38 gastrointestinal adenoma 10.1 F2 GGT1 GPT
39 paranasal sinus sarcoma 10.1 F2 GGT1 GPT
40 lubinsky syndrome 10.1 CD40LG F2
41 t-cell prolymphocytic leukemia 10.1 FAS HLA-DQB1
42 hereditary alpha tryptasemia syndrome 10.1 CD40LG F2 GPT HLA-DRB1
43 benign deep fibrous histiocytoma 10.1 CD40LG F2 GPT HLA-DRB1
44 parasitic helminthiasis infectious disease 10.1 CD40LG HLA-A HLA-DQB1 HLA-DRB1
45 autonomic peripheral neuropathy 10.1 CD40LG DLAT SEPSECS
46 depressed scar 10.0 CD40LG F2 HLA-A HLA-DRB1
47 inflammatory bowel disease 3 10.0 CD40LG CTLA4 HLA-A HLA-DQB1
48 maxillary sinusitis 10.0 CD40LG CYP2D6 F2 GPT
49 hereditary spastic paraplegia 10.0 CTLA4 F2 GGT1 GPT
50 hereditary hemorrhagic telangiectasia 10.0 F2 GGT1 GPT SEPSECS

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to Autoimmune Hepatitis

Symptoms & Phenotypes for Autoimmune Hepatitis

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.06 AIRE CD40LG CTLA4 F2 FAS GGT1
2 homeostasis/metabolism MP:0005376 10 AIRE CD40LG CTLA4 CYP1A2 F2 FAS
3 endocrine/exocrine gland MP:0005379 9.97 PDCD1 AIRE CD40LG CTLA4 CYP1A2 FAS
4 liver/biliary system MP:0005370 9.7 AIRE CTLA4 CYP1A2 FAS HLA-DQB1 KRT8
5 reproductive system MP:0005389 9.56 AIRE CD40LG F2 FAS GGT1 HLA-DQB1
6 respiratory system MP:0005388 9.17 AIRE CTLA4 CYP1A2 F2 FAS HLA-DQB1

Drugs & Therapeutics for Autoimmune Hepatitis

Drugs for Autoimmune Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved Phase 4 79902-63-9 54454
2
Ribavirin Approved Phase 4 36791-04-5 37542
3
Etanercept Approved, Investigational Phase 4,Phase 1,Phase 2 185243-69-0
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
6
chloroquine Approved, Vet_approved Phase 4 54-05-7 2719
7
Mycophenolic acid Approved Phase 4 24280-93-1 446541
8
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
9
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
10
Adalimumab Approved Phase 4 331731-18-1 16219006
11
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
12
Simeprevir Approved Phase 4 923604-59-5 66576988
13
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
14
Entecavir Approved, Investigational Phase 4,Phase 3 142217-69-4 153941
15
Ledipasvir Approved Phase 4 1256388-51-8 67505836
16 Prednisolone acetate Phase 4,Phase 3,Phase 2
17 Rosuvastatin Calcium Phase 4 147098-20-2
18 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
19 glucocorticoids Phase 4,Phase 3,Phase 2
20 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2
21 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
22 Hormone Antagonists Phase 4,Phase 3,Phase 2
23 Hormones Phase 4,Phase 3,Phase 2
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
26 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
27 Hypolipidemic Agents Phase 4
28 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
29 Prednisolone phosphate Phase 4,Phase 3,Phase 2
30 Anti-Infective Agents Phase 4,Phase 3
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2
32 Anticholesteremic Agents Phase 4
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
35 Lipid Regulating Agents Phase 4
36 Antimetabolites Phase 4,Phase 2
37 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
38 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
39 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
40 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
41 Antiviral Agents Phase 4,Phase 3
42 Calcium, Dietary Phase 4
43 Chloroquine diphosphate Phase 4 50-63-5
44 interferons Phase 4
45
protease inhibitors Phase 4
46 HIV Protease Inhibitors Phase 4
47 Anthelmintics Phase 4
48 Antimalarials Phase 4
49 Antimetabolites, Antineoplastic Phase 4,Phase 2
50 Antiparasitic Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 72)
id Name Status NCT ID Phase
1 Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status NCT00866229 Phase 4
2 Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial Completed NCT02463331 Phase 4
3 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4
4 CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS Completed NCT01980745 Phase 4
5 SMV + SOF With/Without RBV for IFN-II Patients With CHC Completed NCT02214420 Phase 4
6 Anti-TNF Agents for the Treatment of Rheumatoid Arthritis Completed NCT00837434 Phase 4
7 Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis Recruiting NCT02900443 Phase 4
8 Entecavir for Biological Agents Associated HBV Reactivation in Inflammatory Arthritis Patients Recruiting NCT01907230 Phase 4
9 Study to Investigate the Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination for 12 Weeks in Subjects With Chronic Genotype 1 and 4 HCV Infection With Autoimmune Disease Not yet recruiting NCT02691728 Phase 4
10 Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis Unknown status NCT01170351 Phase 3
11 Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis Completed NCT00838214 Phase 2, Phase 3
12 Clinical Trial in Patients Diagnosed With Immune Thrombocytopenic Purpura Completed NCT00699140 Phase 3
13 Eltrombopag Phase III Study In Chinese Chronic ITP Patients Active, not recruiting NCT01762761 Phase 3
14 Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis Not yet recruiting NCT02878863 Phase 3
15 Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial Not yet recruiting NCT02473341 Phase 3
16 Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFα Terminated NCT01694264 Phase 3
17 Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis Unknown status NCT01661842 Phase 1, Phase 2
18 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2
19 Oral Administration of Anti-CD3 Monoclonal Antibody in Non-responder Genotype-I Chronic Hepatitis C Subjects Unknown status NCT01459419 Phase 2
20 Evaluation of the Efficacy and Tolerability of Treatment With Interleukin-2 in Severe and Resistant Alopecia Areata Unknown status NCT01840046 Phase 1, Phase 2
21 LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis Completed NCT00608894 Phase 2
22 Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis. Completed NCT02265328 Phase 2
23 Liver Test Study of Using JKB-122 in AIH Patients Recruiting NCT02556372 Phase 2
24 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Recruiting NCT01548690 Phase 2
25 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2
26 Allogeneic Islet Cells Transplanted Onto the Omentum Recruiting NCT02213003 Phase 1, Phase 2
27 Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis Not yet recruiting NCT02704338 Phase 1, Phase 2
28 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Not yet recruiting NCT02997878 Phase 1, Phase 2
29 sPIF CLINICAL STUDY PROTOCOL FOR AUTOIMMUNE HEPATITIS Completed NCT02239562 Phase 1
30 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1
31 Study Of Eltrombopag in Healthy Subjects and Volunteers With Mild, Moderate or Severe Hepatic Impairment Completed NCT00359463 Phase 1
32 Autoimmune Hepatitis Study Terminated NCT00286663 Phase 1
33 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
34 Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis Unknown status NCT00160940
35 Acupuncture as an Adjunctive Treatment for Hepatitis C Patients Unknown status NCT01750515
36 Off-Label Use of Ribavirin in Management of Mucocutaneous Extrahepatic Manifestations of HCV Infection Unknown status NCT02261662
37 Sulfation of Bile Acids as a Biomarker for Hepatobiliary Diseases Unknown status NCT01200082
38 Breath Test for Patients With Acute Liver Disease for Early Detection of the Need for Transplant or Recovery Unknown status NCT01435421
39 Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis Completed NCT01655121
40 Transient Elastography in Autoimmune Hepatitis Completed NCT01905254
41 Immunogenicity and Safety of Vaccinations in Immunocompromised Persons Completed NCT01947465
42 Collections of Blood and Stool Samples in Patients With Acute Hepatitis Completed NCT00001879
43 Plasma Exchange for Autoimmune Autonomic Failure Completed NCT00359346
44 Metabolic Syndrome Feasibility Study Completed NCT02287766
45 Study to Investigate the Immune Response and Safety of Prophylactic Vaccines in Patients Treated for Multiple Sclerosis Completed NCT02275741
46 An Observational Study to Describe in Routine Clinical Practice the Treatment Patterns of Usage of Biological DMARDs in RA Patients. Completed NCT02590562
47 De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Recruiting NCT02056054
48 The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis Recruiting NCT02050646
49 Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis Recruiting NCT02950077
50 Study of the Clinical Features of Autoimmune Hepatitis Recruiting NCT02994537

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: hepatitis, autoimmune

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

MalaCards organs/tissues related to Autoimmune Hepatitis:

39
Liver, T Cells, Testes, Thyroid, Bone, Kidney, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Hepatitis:

18
Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
id Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Autoimmune Hepatitis

Articles related to Autoimmune Hepatitis:

(show top 50) (show all 933)
id Title Authors Year
1
Autoimmune Hepatitis Associated with Immune Thrombocytopenic Purpura. ( 28090042 )
2017
2
A Acute hepatitis E mimicking a flare of disease in a patient with chronic autoimmune hepatitis. ( 28051806 )
2017
3
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. ( 28491884 )
2017
4
CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-I^ production by CD4(+) T cells. ( 28065940 )
2017
5
Autoimmune hepatitis and eosinophilic granulomatosis with polyangiitis: a rare association. ( 28108440 )
2017
6
IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis. ( 27956525 )
2017
7
Imaging of autoimmune hepatitis and overlap syndromes. ( 27999888 )
2017
8
Prognostic value of clinical variables and liver histology for development of fibrosis and cirrhosis in autoimmune hepatitis. ( 27846740 )
2017
9
Influence of Liver Inflammation on Liver Stiffness Measurement in Patients with Autoimmune Hepatitis Evaluation by Combinational Elastography. ( 28056459 )
2017
10
Expert clinical management of autoimmune hepatitis in the real world. ( 28004405 )
2016
11
The Management of Autoimmune Hepatitis Patients with Decompensated Cirrhosis: Real-World Experience and a Comprehensive Review. ( 27515672 )
2016
12
Autoimmune hepatitis in a child presenting with hepatopulmonary syndrome (HPS). ( 26992455 )
2016
13
Low-grade elevation of fibrinogen-degradation products is an important parameter to identify acute presentation of autoimmune hepatitis. ( 27161820 )
2016
14
Autoimmune hepatitis: From mechanisms to therapy. ( 27161382 )
2016
15
Editorial: autoimmune hepatitis - identifying options forA treatment. Authors' reply. ( 27137726 )
2016
16
The Use of Tacrolimous in Refractory Autoimmune Hepatitis in Children and Adults: A Single Center Experience. ( 27633047 )
2016
17
Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis. ( 26744892 )
2016
18
Evaluate of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis. ( 27505153 )
2016
19
Autoimmune hepatitis following drug-induced liver injury in an elderly patient. ( 27170297 )
2016
20
Autoimmune hepatitis: an uncommon presentation of thymoma. ( 27079907 )
2016
21
Toxin-Induced Autoimmune Hepatitis Caused by Raw Cashew Nuts. ( 27807585 )
2016
22
Pregnancy with autoimmune hepatitis. ( 27458515 )
2016
23
Concurrent extrahepatic autoimmunity in autoimmune hepatitis: implications for diagnosis, clinical course and long-term outcomes. ( 27541063 )
2016
24
The induction of autoimmune hepatitis in the human leucocyte antigen-DR4 non-obese diabetic mice autoimmune hepatitis mouse model. ( 27414259 )
2016
25
Editorial: autoimmune hepatitis - identifying options for treatment. ( 27137725 )
2016
26
Case Report of Sweet's Syndrome Associated With Autoimmune Hepatitis. ( 27534778 )
2016
27
Anaerococcus urinomassiliensis sp. nov., isolated from a urine sample of a 17-year-old boy affected by autoimmune hepatitis and membranoproliferative glomerulonephritis. ( 27408746 )
2016
28
Contemporary issues and future directions in autoimmune hepatitis. ( 27215278 )
2016
29
The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes. ( 26890333 )
2016
30
Corrigendum to "Autoimmune Hepatitis: Progress from Global Immunosuppression to Personalised Regulatory T Cell Therapy". ( 27990413 )
2016
31
Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on DCs-CD8(+) T cells communication. ( 27639182 )
2016
32
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice. ( 27796295 )
2016
33
Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis. ( 27511737 )
2016
34
Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis. ( 27516526 )
2016
35
Protocol of a prospective study for the combination treatment of Shu-Gan-jian-Pi decoction and steroid standard therapy in autoimmune hepatitis patients. ( 27923369 )
2016
36
Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles. ( 27206238 )
2016
37
IL4 gene polymorphisms in Iranian patients with autoimmune hepatitis. ( 26735262 )
2016
38
Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. ( 27183637 )
2016
39
Nonalcoholic Fatty Liver Disease in Patients with Autoimmune Hepatitis: Further Reason for Teeth GNASHing? ( 27468739 )
2016
40
Increasing incidence of elderly-onset autoimmune hepatitis. ( 27531184 )
2016
41
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan. ( 27406031 )
2016
42
Autoimmune hepatitis in Pakistan. ( 27924956 )
2016
43
Strongyloides stercoralis hyperinfection in patient with autoimmune hepatitis and purpura fulminans. ( 26955218 )
2016
44
Evaluation of the effectiveness of treatment with prednisone and azathioprine of autoimmune hepatitis in children. ( 27110306 )
2016
45
Prevalence and Risk Factors of Diabetes Mellitus in Patients with Autoimmune Hepatitis. ( 27086799 )
2016
46
Difference in clinical presentation, immunology profile and treatment response of type 1 autoimmune hepatitis between United Kingdom and Singapore patients. ( 27101826 )
2016
47
The influence of genetic predisposition and autoimmune hepatitis inducing antigens in disease development. ( 27974250 )
2016
48
Soluble programmed death-1 levels are associated with disease activity and treatment response in patients with autoimmune hepatitis. ( 27604386 )
2016
49
Real-time shear wave elastrography and APRI index for evaluating autoimmune hepatitis fibrosis. ( 28078847 )
2016
50
Over-the-counter Drug Induced Autoimmune Hepatitis. ( 27181535 )
2016

Variations for Autoimmune Hepatitis

Expression for Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for Autoimmune Hepatitis

Pathways related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1 12.29 CD40LG CTLA4 FAS PDCD1
2
Show member pathways
12.17 CD40LG CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
3
Show member pathways
12.15 CD40LG CTLA4 FAS PDCD1
4
Show member pathways
12.09 CD40LG CTLA4 HLA-DQB1 HLA-DRB1
5
Show member pathways
11.69 HLA-DQB1 HLA-DRB1 PDCD1
6
Show member pathways
11.69 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
7 11.59 CTLA4 HLA-DQB1 HLA-DRB1
8 11.4 CTLA4 HLA-DQB1 HLA-DRB1
9 11.34 CD40LG CTLA4 PDCD1
10 11.26 CD40LG CTLA4 HLA-A HLA-DQB1 HLA-DRB1 PDCD1
11 11.2 CD40LG CTLA4 PDCD1

GO Terms for Autoimmune Hepatitis

Cellular components related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 F2 FAS FTCD GGT1 GPT HLA-A
2 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-DQB1 HLA-DRB1
3 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-A HLA-DQB1 HLA-DRB1
5 external side of plasma membrane GO:0009897 9.1 CD40LG CTLA4 F2 FAS HLA-DRB1 PDCD1

Biological processes related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.7 CYP1A2 CYP2D6 GGT1
2 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-DQB1 HLA-DRB1
3 antigen processing and presentation GO:0019882 9.63 HLA-A HLA-DQB1 HLA-DRB1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.55 HLA-DQB1 HLA-DRB1
5 hepatocyte apoptotic process GO:0097284 9.54 FAS KRT8
6 negative thymic T cell selection GO:0045060 9.51 AIRE FAS
7 immune response GO:0006955 9.5 AIRE CD40LG CTLA4 FAS HLA-A HLA-DQB1
8 oxidative demethylation GO:0070989 9.49 CYP1A2 CYP2D6
9 drug catabolic process GO:0042737 9.43 CYP1A2 CYP2D6
10 heterocycle metabolic process GO:0046483 9.4 CYP1A2 CYP2D6
11 monoterpenoid metabolic process GO:0016098 9.37 CYP1A2 CYP2D6
12 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.32 HLA-DQB1 HLA-DRB1
13 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.26 HLA-DQB1 HLA-DRB1
14 alkaloid metabolic process GO:0009820 9.16 CYP1A2 CYP2D6
15 T cell costimulation GO:0031295 9.02 CD40LG CTLA4 HLA-DQB1 HLA-DRB1 PDCD1

Molecular functions related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.16 CYP1A2 CYP2D6
2 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
3 peptide antigen binding GO:0042605 8.8 HLA-A HLA-DQB1 HLA-DRB1

Sources for Autoimmune Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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