AIH
MCID: ATM011
MIFTS: 60

Autoimmune Hepatitis (AIH) malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Autoimmune Hepatitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. this immune response causes inflammation of the liver, also called hepatitis. the disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. autoimmune hepatitis sometimes occurs in relatives of people with autoimmune diseases, suggesting a genetic cause. this disease is most common in young girls and women. last updated: 6/8/2011

MalaCards: Autoimmune Hepatitis, also known as autoimmune hepatitis with centrilobular necrosis, is related to hepatitis and primary biliary cirrhosis. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways is Codeine and morphine metabolism. The compounds mycophenolate mofetil and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and thyroid, and related mouse phenotype hematopoietic system.

Disease Ontology:8 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia:63 Autoimmune Hepatitis is a disease of the liver that occurs when the body\'s immune system attacks cells... more...

Aliases & Classifications for Autoimmune Hepatitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Characteristics (Orphanet epidemiological data):

48
autoimmune hepatitis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

autoimmune hepatitis 8 42 10 48 30
autoimmune hepatitis with centrilobular necrosis 8
autoimmune chronic active hepatitis 8
chronic autoimmune hepatitis 48
autoimmune chronic hepatitis 42
hepatitis, autoimmune 60
hepatitis autoimmune 44
aih 42


External Ids:

Disease Ontology8 DOID:2048
MeSH34 D019693
ICD9CM27 571.42
NCIt39 C27029
ICD10 via Orphanet26 K75.4
SNOMED-CT via Orphanet57 408335007
ICD1025 K75.4

Related Diseases for Autoimmune Hepatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
autoimmune hepatitis Hepatitis D
Hepatitis a Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.0ARG1, GPT, SEPSECS, ASGR2
2primary biliary cirrhosis31.2CTLA4, AIRE, GPT, SEPSECS, ASGR2
3cholangitis30.9SEPSECS, GPT
4hepatitis c30.9CTLA4, CYP2D6, GPT, ASGR2
5sclerosing cholangitis30.9SEPSECS
6hepatocellular carcinoma30.7ASGR2, GPT, ARG1, CTLA4, TNFRSF6B
7lupus erythematosus30.7C4A
8hepatitis b30.6CTLA4, GPT, ASGR2
9systemic lupus erythematosus30.6C4A
10arthritis30.5CTLA4
11rheumatoid arthritis30.4TPMT, CTLA4, TNFRSF6B
12inflammatory bowel disease30.3TPMT
13graves' disease30.1CTLA4, HLA-DRB3, AIRE
14psoriasis30.1CTLA4, HLA-S, ARG1
15hypothyroidism30.1AIRE, CTLA4
16diabetes mellitus29.9GPT, AIRE, CTLA4
17multiple sclerosis29.9TPMT, CYP2D6, CTLA4
18addison's disease29.9CYP2D6, AIRE, CTLA4
19ipex syndrome29.9C4A, HLA-S, AIRE, CYP2D6, GPT
20hepatitis a11.1
21liver disease10.6
22drug-induced hepatitis10.5
23autoimmune thyroiditis10.4
24thyroiditis10.4
25celiac disease10.4
26liver cirrhosis10.4
27connective tissue disease10.3
28mixed connective tissue disease10.3
29ulcerative colitis10.3
30viral hepatitis10.3
31crohn's disease10.3
32autoimmune thrombocytopenic purpura10.3
33autoimmune hemolytic anemia10.3
34adult-onset still's disease10.3
35hemolytic anemia10.3
36purpura10.3
37acute liver failure10.2
38hepatitis d10.2
39bernard-soulier syndrome10.2
40visceral leishmaniasis10.2
41polyarteritis nodosa10.2
42leishmaniasis10.2
43thrombocytopenia10.2
44thymoma10.2
45membranous glomerulonephritis10.1
46evans' syndrome10.1
47epstein-barr virus hepatitis10.1
48pyoderma gangrenosum10.1
49osteoporosis10.1
50autoimmune polyendocrine syndrome10.1

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to autoimmune hepatitis

Clinical Features for Autoimmune Hepatitis

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Drugs & Therapeutics for Autoimmune Hepatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Hepatitis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hepatitis

Search NIH Clinical Center for Autoimmune Hepatitis

Search CenterWatch for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Genetic Tests for Autoimmune Hepatitis

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Anatomical Context for Autoimmune Hepatitis

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Sources:
30LifeMap Discovery™, 32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Autoimmune Hepatitis:

32
Liver, Thyroid, T cells, Bone marrow, Bone, Kidney, Pancreas, B cells, Smooth muscle, Testes, Myeloid, Skin, Salivary gland, Pancreatic islet, Heart, Spleen, Lymph node

FMA organs/tissues related to Autoimmune Hepatitis:

14
Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autoimmune Hepatitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Autoimmune Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.6TPMT, ASGR2, ASIP, ASGR1, PTPRCAP, AIRE

Publications for Autoimmune Hepatitis

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Sources:
50PubMed
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Articles related to Autoimmune Hepatitis:

(show top 50)    (show all 916)
idTitleAuthorsYear
1
Systematic review with meta-analysis: clinical manifestations and management of autoimmune hepatitis in the elderly. (24261965)
2014
2
Autoimmune hepatitis associated with leprosy in a child. (22331015)
2013
3
Hepatocellular carcinoma and other malignancies in autoimmune hepatitis. (23306849)
2013
4
Review article: the management of autoimmune hepatitis beyond consensus guidelines. (23808490)
2013
5
Non-invasive markers of inflammation in autoimmune hepatitis. (24011359)
2013
6
Acute presentation of autoimmune hepatitis: How to find and manage still remains unsolved. (23730706)
2013
7
Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10. (23902475)
2013
8
Myocardial performance in children with autoimmune hepatitis: Doppler tissue imaging study. (23812510)
2013
9
Giant cell hepatitis with autoimmune hemolytic anemia in a nine month old infant. (23671728)
2013
10
Autoimmune hepatitis in Mexican patients. (23388846)
2013
11
Autoimmune Hepatitis Triggered by Anti-TNF-I+ Therapy. (24082887)
2013
12
Diagnostic difficulties, therapeutic strategies, and performance of scoring systems in patients with autoimmune hepatitis and concurrent hepatitis B/C. (23448312)
2013
13
Drug choices in autoimmune hepatitis: part A--Steroids. (23061711)
2012
14
Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus; review of literature. (22027758)
2012
15
Diagnosis and treatment of autoimmune hepatitis. (22722441)
2012
16
Severe acute autoimmune hepatitis after natalizumab treatment. (22154948)
2012
17
Identification of new autoantigens by protein array indicates a role for IL4 neutralization in autoimmune hepatitis. (22997428)
2012
18
The benefit of animal models for autoimmune hepatitis. (22117631)
2011
19
Clinical expression of autoimmune hepatitis in a nine-year-old girl with visceral leishmaniasis. (21866471)
2011
20
Performance parameters of the conventional serological markers for autoimmune hepatitis. (21127976)
2011
21
Recognizing autoimmune hepatitis: scores help, but no more. (21093949)
2011
22
Overlap syndrome of autoimmune hepatitis and primary biliary cirrhosis triggered by fluvastatin. (21503830)
2011
23
De novo autoimmune hepatitis after liver transplantation. (21344352)
2011
24
Histological Remission during Corticosteroid Therapy of Overlapping Nonalcoholic Steatohepatitis and Autoimmune Hepatitis: Case Report and Literature Review. (22110414)
2011
25
A 50-year experience with autoimmune hepatitis: and where are we now? (21072544)
2011
26
Clinicopathological features of severe and fulminant forms of autoimmune hepatitis. (20821236)
2011
27
Autoimmune hepatitis in patients with primary SjAPgren's syndrome: a series of two-hundred and two patients. (20661405)
2010
28
Hepatic stellate cell activation and hepatic fibrosis in children with type 1 autoimmune hepatitis: an immunohistochemical study of paired liver biopsies before treatment and after clinical remission. (20009940)
2010
29
Successful living donor liver transplantation for severe hepatic GVHD histologically resembling autoimmune hepatitis after bone marrow transplantation from the same sibling donor. (20028495)
2010
30
Cloning and expression of 3-phosphoglycerate dehydrogenase gene and its correlative antibodies in diagnosis of autoimmune hepatitis]. (19497206)
2009
31
AIRE gene analysis in children with autoimmune hepatitis type I or II. (19322061)
2009
32
Autoantibodies and their antigens in autoimmune hepatitis. (19675997)
2009
33
Treatment of autoimmune thrombocytopenia in a case of chronic hepatitis C with ursodeoxycholic acid. (19801810)
2009
34
HLA class II association with autoimmune hepatitis in Latin America: a meta-analysis. (19041429)
2009
35
Etiology of hemolysis in two patients with hepatitis A infection: glucose-6-phosphate dehydrogenase deficiency or autoimmune hemolytic anemia. (18320220)
2008
36
A case of autoimmune hepatitis exacerbated by the administration of etanercept in the patient with rheumatoid arthritis. (18563514)
2008
37
Development of autoimmune hepatitis in a child with systemic-onset juvenile idiopathic arthritis during therapy with etanercept. (18824922)
2008
38
Clinical significance of HLA DRB103-DRB104 in type 1 autoimmune hepatitis. (17105585)
2006
39
Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: a case report. (16552828)
2006
40
A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis. (16946565)
2006
41
Nonstandard antibodies as prognostic markers in autoimmune hepatitis. (15497452)
2004
42
Characterization of the B cell response of patients with anti-liver cytosol autoantibodies in type 2 autoimmune hepatitis. (12811847)
2003
43
Autoimmune hepatitis and overlap syndrome: diagnosis]. (12233264)
2002
44
A patient with autoimmune hepatitis type I, Addison's disease, atrophic thyroiditis, atrophic gastritis, exocrine pancreatic insufficiency, and heterozygous alpha1-antitrypsin deficiency. (12003388)
2002
45
CTLA-4/CD 28 region polymorphisms in children from families with autoimmune hepatitis. (11756004)
2001
46
Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study. (10677250)
2000
47
A case of Graves' disease associated with autoimmune hepatitis and mixed connective tissue disease. (10426583)
1999
48
Effect of ursodeoxycholic acid on autoimmune-associated chronic hepatitis C. (10355503)
1999
49
Transforming growth factor-beta1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity. (9625315)
1998
50
Prolonged intrahepatic cholestasis in acute-onset, severe autoimmune hepatitis. (9213259)
1997

Genetic Variations for Autoimmune Hepatitis

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Expression for genes affiliated with Autoimmune Hepatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for genes affiliated with Autoimmune Hepatitis

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Sources:
37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CYP2D6, CYP2D7P1

Compounds for genes affiliated with Autoimmune Hepatitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1mycophenolate mofetil44 49 1112.8TPMT, SEPSECS, GPT, CTLA4
2cyclosporin a44 28 5912.8CTLA4, HLA-S, GPT, SEPSECS, TPMT
3Pyridoxal Phosphate1110.8PDXP, FTCD, GPT, SEPSECS
4methotrexate44 49 1112.8TPMT, GPT, HLA-S, CTLA4
5steroid4410.7TPMT, SEPSECS, CYP2D6, C4A, CTLA4
6perhexiline44 1111.7CYP2D6, TPMT
7bupivacaine44 28 1112.7GPT, CYP2D6
8efavirenz44 49 1112.6CYP2D6, GPT
96 mercaptopurine4410.5TPMT, GPT
10pyridoxal44 11 2412.5GPT, PDXP
11nevirapine44 49 1112.4GPT, CYP2D6
12thiopurine4410.2TPMT, CYP2D6

GO Terms for genes affiliated with Autoimmune Hepatitis

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Sources:
16Gene Ontology
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Molecular functions related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asialoglycoprotein receptor activityGO:00487310.5ASGR2, ASGR1

Products for genes affiliated with Autoimmune Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet