AIH
MCID: ATM011
MIFTS: 61

Autoimmune Hepatitis (AIH) malady

Rare diseases, Gastrointestinal diseases, Liver diseases, Immune diseases, Infectious diseases categories
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Summaries for Autoimmune Hepatitis

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NIH Rare Diseases:42 Autoimmune hepatitis is a disease in which the bodyÔÇÖs immune system attacks liver cells. this immune response causes inflammation of the liver, also called hepatitis.┬áthe disease┬ácan be┬áquite serious and, if not treated, gets worse over time, leading to┬ácirrhosis of the liver┬áand/or liver failure.┬áautoimmune hepatitis sometimes occurs in relatives of people with autoimmune diseases, suggesting a genetic cause. this disease is most common in young girls and women. last updated: 6/8/2011

MalaCards based summary: Autoimmune Hepatitis, also known as autoimmune hepatitis with centrilobular necrosis, is related to hepatitis and primary biliary cirrhosis. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are One carbon pool by folate and Metabolism. The compounds perhexiline and thiopurine have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells, and related mouse phenotypes are liver/biliary system and normal.

Disease Ontology:8 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia:65 Autoimmune Hepatitis is a disease of the liver that occurs when the body\'s immune system attacks cells... more...

Aliases & Classifications for Autoimmune Hepatitis

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 62UMLS, 44Novoseek, 34MeSH, 57SNOMED-CT, 39NCIt, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Autoimmune Hepatitis, Aliases & Descriptions:

Name: Autoimmune Hepatitis 30 8 42 10 48
Autoimmune Hepatitis with Centrilobular Necrosis 8 62
Autoimmune Chronic Active Hepatitis 8 62
Autoimmune Chronic Hepatitis 42 62
 
Chronic Autoimmune Hepatitis 48
Hepatitis, Autoimmune 62
Hepatitis Autoimmune 44
Aih 42


Classifications:

Orphanet: 48 
Rare hepatic diseases


Characteristics (Orphanet epidemiological data):

48
autoimmune hepatitis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:2048
MeSH34 D019693
NCIt39 C27029
ICD9CM27 571.42
ICD10 via Orphanet26 K75.4
UMLS via Orphanet63 C0241910
ICD1025 K75.4

Related Diseases for Autoimmune Hepatitis

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Diseases in the Hepatitis C family:

autoimmune hepatitis Hepatitis
Hepatitis B Hepatitis D
Hepatitis a Hepatitis E
Viral Hepatitis Hepatitis C Virus
Susceptibility to Hepatitis Due to Voriconazole Treatment Susceptibility to Hepatitis Due to Flucloxacilline Treatment

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.2ARG1, SEPSECS
2primary biliary cirrhosis31.5SEPSECS, AIRE, CTLA4
3thyroiditis31.4CTLA4
4lupus erythematosus31.2C4A
5systemic lupus erythematosus31.1C4A
6autoimmune thyroiditis30.6CTLA4, AIRE
7thymoma30.5AIRE, CTLA4
8vasculitis30.5TPMT, CTLA4
9rheumatoid arthritis30.4TNFRSF6B, CTLA4, FCRL3, TPMT
10vitiligo30.3AIRE, CTLA4
11myasthenia gravis30.2CTLA4, AIRE
12graves' disease30.2CTLA4, AIRE, FCRL3
13multiple sclerosis30.1CYP2D6, TPMT, CTLA4
14addison's disease30.1CTLA4, CYP2D6, AIRE
15diabetes mellitus29.9CTLA4, AIRE
16hepatitis a10.7
17cholangitis10.7
18sclerosing cholangitis10.6
19hepatitis c10.6
20primary sclerosing cholangitis10.6
21hepatocellular carcinoma10.5
22celiac disease10.5
23liver disease10.5
24arthritis10.4
25colitis10.4
26connective tissue disease10.4
27alopecia areata10.4AIRE
28ulcerative colitis10.4
29mixed connective tissue disease10.4
30acute liver failure10.3
31crohn's disease10.3
32hemolytic anemia10.3
33hepatitis b10.3
34adult-onset still's disease10.3
35purpura10.3
36polymyositis10.3
37hepatitis c virus10.3
38wegener's granulomatosis10.3CTLA4, TPMT
39autoimmune hemolytic anemia10.3
40viral hepatitis10.3
41inflammatory bowel disease10.3
42graft versus host disease10.3CTLA4, SEPSECS
43hypoparathyroidism10.2CTLA4, AIRE
44bernard-soulier syndrome10.2
45thrombocytopenia10.2
46polyarteritis nodosa10.2
47visceral leishmaniasis10.2
48pyoderma gangrenosum10.2
49leishmaniasis10.2
50pyoderma10.2

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to autoimmune hepatitis

Symptoms for Autoimmune Hepatitis

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Drugs & Therapeutics for Autoimmune Hepatitis

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Hepatitis

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Genetic Tests for Autoimmune Hepatitis

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Anatomical Context for Autoimmune Hepatitis

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MalaCards organs/tissues related to Autoimmune Hepatitis:

32
Liver, T cells, Thyroid, Bone marrow, Bone, Kidney, Pancreas, Smooth muscle, B cells, Neutrophil, Lymph node, Spleen, Heart, Skin, Testes, Myeloid

FMA organs/tissues related to Autoimmune Hepatitis:

14
Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autoimmune Hepatitis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Hepatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7ARG1, CTLA4, ASIP, AIRE
2MP:00028737.9ARG1, AIRE, PTPRCAP, ASIP, CTLA4
3MP:00053977.8ASIP, AIRE, PTPRCAP, TPMT, ARG1, CTLA4

Publications for Autoimmune Hepatitis

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Articles related to Autoimmune Hepatitis:

(show top 50)    (show all 791)
idTitleAuthorsYear
1
Review article: the prevention and reversal of hepatic fibrosis in autoimmune hepatitis. (24387318)
2014
2
Anti-SLA/LP alone or in combination with anti-Ro52 and fine specificity of anti-Ro52 antibodies in patients with autoimmune hepatitis. (25113420)
2014
3
Regulatory T cells and autoimmune hepatitis: What happens in the liver stays in the liver. (25131772)
2014
4
Fetal intestinal perforation and meconium peritonitis associated with maternal autoimmune hepatitis. (24815708)
2014
5
Hashimoto's thyroiditis concomitant with sequential autoimmune hepatitis, chorea and polyserositis: a new entity of autoimmune polyendocrine syndrome? (23318858)
2013
6
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact? (23293207)
2013
7
Infliximab as a rescue treatment in difficult-to-treat autoimmune hepatitis. (23178709)
2013
8
SPRi-Based Strategy to Identify Specific Biomarkers in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Autoimmune Hepatitis. (24376828)
2013
9
Autoimmune hepatitis on the rise. (24295874)
2013
10
Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: a nationwide, multicenter study. (23033899)
2013
11
Drug choices in autoimmune hepatitis: part A--Steroids. (23061711)
2012
12
Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence. (22345339)
2012
13
The CYP2D6 animal model: how to induce autoimmune hepatitis in mice. (22331063)
2012
14
Role of thiopurine metabolite measurement in the management of autoimmune hepatitis. (22589202)
2012
15
Clinical features and long term outcome of 102 treated autoimmune hepatitis patients. (22509185)
2012
16
Histopathology of de novo autoimmune hepatitis. (22378542)
2012
17
Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus; review of literature. (22027758)
2012
18
Hepatitis surface antigen clearance in a woman with liver cirrhosis and concomitant autoimmune hepatitis under immunosuppressive therapy. (23181542)
2012
19
Diagnosis and treatment of autoimmune hepatitis. (22179843)
2012
20
Autoimmune hepatitis in children: an overview of the disease focusing on current therapies. (22495399)
2012
21
Association of TBX21 promoter polymorphisms with type 1 autoimmune hepatitis in a Chinese population. (20977921)
2011
22
Optimizing management in autoimmune hepatitis with liver failure at initial presentation. (21547124)
2011
23
Advanced histology and impaired liver regeneration are associated with disease severity in acute-onset autoimmune hepatitis. (21401703)
2011
24
The benefit of animal models for autoimmune hepatitis. (22117631)
2011
25
Mycophenolate mofetil as a rescue therapy for autoimmune hepatitis patients who are not responsive to standard therapy. (21780898)
2011
26
Requirements and challenges of a preclinical autoimmune hepatitis mouse model. (21894011)
2011
27
Performance of the international classifications criteria for autoimmune hepatitis diagnosis in Mexican patients. (21875376)
2011
28
Seven cases of autoimmune hepatitis that developed after drug-induced liver injury. (21725992)
2011
29
Acquired haemophilia A in a woman with autoimmune hepatitis and systemic lupus erythematosus: review of literature. (21885954)
2011
30
Risk factors associated with relapse of type 1 autoimmune hepatitis in Japan. (21711423)
2011
31
Autoimmune hepatitis type 2 following anti-papillomavirus vaccination in a 11-year-old girl. (21596082)
2011
32
Another cause of autoimmune hepatitis. (20578154)
2010
33
Corticosteroid-induced mania in a patient with autoimmune hepatitis. (20220360)
2010
34
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
35
Clinical features of 107 autoimmune hepatitis patients and 30 of them with AIH-primary biliary cirrhosis overlap syndrome]. (18510851)
2008
36
Effects of serum aspartate aminotransferase levels in patients with autoimmune hepatitis influence disease course and outcome. (18840547)
2008
37
Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. (18200656)
2008
38
A functional Fas promoter polymorphism is associated with a severe phenotype in type 1 autoimmune hepatitis characterized by early development of cirrhosis. (17493146)
2007
39
Selenocysteine, soluble liver antigen/liver-pancreas, and autoimmune hepatitis. (17596869)
2007
40
Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. (16876902)
2006
41
Scleroderma-like lesions in the course of autoimmune hepatitis. Case report]. (16334539)
2005
42
Use of etanercept in treatment of pyoderma gangrenosum in a patient with autoimmune hepatitis. (16428159)
2005
43
Secondary IgA nephropathy presenting as nephrotic syndrome with glomerular crescentic changes and acute renal failure in a patient with autoimmune hepatitis. (15151269)
2004
44
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
45
HLA genotyping in type-I autoimmune hepatitis in Western India. (14719586)
2003
46
Anti-cytokeratin antibodies in sera of the patients with autoimmune hepatitis. (11529922)
2001
47
Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1. (11343230)
2001
48
Autoimmune cholangitis with features of autoimmune hepatitis: successful treatment with immunosuppressive agents and ursodeoxycholic acid. (10719755)
2000
49
The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. (11092254)
2000
50
Apoptosis and hepatic cell proliferation in autoimmune hepatitis and chronic viral hepatitis C in children: analysis of APO-1/Fas (CD95), bcl-2 and Ki67 expression]. (10910654)
1999

Variations for Autoimmune Hepatitis

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Expression for genes affiliated with Autoimmune Hepatitis

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Expression patterns in normal tissues for genes affiliated with Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for genes affiliated with Autoimmune Hepatitis

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Pathways related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.8FTCD, TPMT
2
Show member pathways
8.4ARG1, FTCD, TPMT, TNFRSF6B, CYP2D6

Compounds for genes affiliated with Autoimmune Hepatitis

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Compounds related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1perhexiline44 1111.0CYP2D6, TPMT
2thiopurine4410.0TPMT, CYP2D6
3halothane44 50 28 1113.0SEPSECS, CYP2D6
4Pyridoxal 5'-phosphate2410.0FTCD, SEPSECS
5uridine diphosphate4410.0TPMT, CYP2D6
6bortezomib44 50 1111.9CYP2D6, CTLA4
7mycophenolate mofetil44 50 1111.8TPMT, SEPSECS, CTLA4
8xanthine44 2410.7TPMT, CYP2D6
9isoleucine449.5CYP2D6, ARG1
10cyclosporin a44 28 6111.3TPMT, CTLA4, SEPSECS
11tyrosine448.7CYP2D6, AIRE, PTPRCAP, TPMT, CTLA4
12steroid448.7CYP2D6, TPMT, SEPSECS, CTLA4, C4A

GO Terms for genes affiliated with Autoimmune Hepatitis

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Products for genes affiliated with Autoimmune Hepatitis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Autoimmune Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet