Search MalaCards:
AIH
MCID: ATM011

Autoimmune Hepatitis malady
2 drugs, 126 genes, 8 tissues, 1148 related diseases, 21 phenotypes, 217 articles, clinical trials.

Summaries for Autoimmune Hepatitis

about this section
Sources:
6Disease Ontology, 30NIH Rare Diseases, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
NIH Rare Diseases: Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. This immune response causes inflammation of the liver, also called hepatitis. The disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. Autoimmune hepatitis sometimes occurs in relatives of people with autoimmune diseases, suggesting a genetic cause. This disease is most common in young girls and women.30

MalaCards: Autoimmune Hepatitis, also known as autoimmune hepatitis with centrilobular necrosis, is related to hepatitis and alcoholism. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways are Antigen processing and presentation and MHC class II antigen presentation. The drugs astragalus and astragalus extract and the compounds ivig and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related mouse phenotypes are respiratory system and renal/urinary system.

Disease Ontology: An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.6

Wikipedia: Autoimmune Hepatitis is a disease of the liver that occurs when the body\'s immune system attacks cells...44 more...

Aliases & Descriptions for Autoimmune Hepatitis

about this section
Sources:
6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 27NCIt, 40SNOMED-CT, 24MeSH
See all sources

Aliases & Descriptions:

autoimmune hepatitis 6 30 8
autoimmune hepatitis with centrilobular necrosis 6
autoimmune chronic active hepatitis 6
autoimmune hepatitis (disorder) 6
autoimmune chronic hepatitis 30
hepatitis, autoimmune 43
hepatitis autoimmune 32
hepatitis 43
aih 30

External Ids:

ICD9CM19 571.42

Related Diseases for Autoimmune Hepatitis

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Diseases related to autoimmune hepatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1145)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis39.7GPT, IFNA1, SLC17A5
2alcoholism36.2CNR1, IL1RN, GPT, TPMT, CYP2B6, ABCB7
3liver cirrhosis34.0RETN, CNR1, SEPSECS, UGT1A, CD14, GPT
4hepatitis e33.9CD40LG, GPT, IFNA1, IFNG, F2, ALB
5alcoholic hepatitis33.7IL10, F2, TNF
6hepatic encephalopathy33.1IL6, GPT, F2, ALB, TNF, SLC17A5
7hepatitis d32.4REXO1L1, CD40LG, GPT, IFNA1, F2, TNF
8colorectal cancer32.3VDR, UGT1A1, GSTM1, GSTT1, TNF, CYP2D6
9non-a-e hepatitis31.8GPT, F2, SLC17A5
10primary biliary cirrhosis31.8SEPSECS, VDR, VCP, CIITA, CD79A, CD40LG
11drug-induced hepatitis31.6UGT1A1, UGT1A6, B3GAT2, GSTM1, GSTT1, GPT
12porphyria cutanea tarda31.4SEPSECS, BMP6, GSTM1, GSTT1, IFNA1, ALB
13systemic lupus erythematosus31.0FOXP3, FCGR2B, CTLA4, C4A
14primary sclerosing cholangitis30.8GPT, AIRE, HLA-A, HLA-C, DLAT, GGT1
15sepsis30.7CD14, IL10, TNF, LTA
16hepatic tuberculosis30.2F2, ALB, ALPP, GGT1
17aplastic anemia30.0GZMB, GSTM1, GSTT1, FAS, IFNG, TRB@
18glycogen storage disease29.8BMP6, FTCD, CDKN3, F2, ALB, SOD1
19giant cell hepatitis29.6GOLM1, CYP1A2, CYP17A1, CYP21A2, GGT1
20citrin deficiency29.4GPT, F2, SLC17A5
21acute liver failure29.3GPT, F2, ALB, SLC17A5
22rheumatoid arthritis29.3CIITA, HLA-DRB1, NFKBIL1
23autoimmune thyroiditis29.3CIITA, IL2RA, IL4, FAS, IFNG, AIRE
24hepatitis c29.1CIITA, CD28, CD40LG, ASGR2, IL10, IL2
25polyarteritis nodosa29.1CD40LG, IL6, GPT, IFNA1
26cryoglobulinemia29.0REXO1L1, BMP6, CD79A, CD40LG, IL10, IL1B
27hodgkin's lymphoma28.9CD28, GZMB, IL1RN, IL2, IL2RA, HLA-A
28obstructive jaundice28.7GPT, ALPP, SLC17A5, GGT1
29portal vein thrombosis28.6IFNA1, F5, F2, ALB, CYP2C9, ABCB7
30nonalcoholic steatohepatitis28.6RETN, BMP6, IL1B, IL6, FAS, GPT
31primary hyperoxaluria28.6CD79A, GOT1, F2, ALB, ALPP, CYP2B6
32hemochromatosis28.5BMP6, UGT1A1, IL6, GPT, F5, F2
33portal hypertension28.5GPT, IFNA1, F2, ALB, TNF, NOS2
34gilbert syndrome28.4UGT1A, UGT1A1, TPMT
35autoimmune lymphoproliferative syndrome28.3IL10, IL2RA, FAS, IGHE, PTPRC
36b-cell lymphomas28.3CNR1, CIITA, BAX, CD14, GZMB, FCGR2B
37cystic echinococcosis28.2IL2RA, IGHE, HLA-B, HLA-DRB1
38chronic granulomatous disease28.2CD79A, CD14, CD40LG, GPT, IFNG, TNF
39type 2 diabetes mellitus28.1RETN, CNR1, ASIP, IL6, GPT, ALB
40iron overload28.1VDR, BMP6, UGT1A1, GSTM1, GPT, IFNA1
41galactosemia27.9GPT, F5, F2, ALB, ABCB7, SLC17A5
42liver cancer27.9BMP6, BAX, CEACAM3, CDKN3, IL2, IL6
43neonatal intrahepatic cholestasis caused by citrin deficiency27.9GPT, F2, SLC17A5
44hepatocellular cancer27.7BMP6, BAX, IL2RA, F2, SOD1
45reye syndrome27.7CES1, GPT, IFNG, GOT1, GOT2
46lymphoproliferative syndrome27.6CD40LG, IL10, IL2, IL2RA, FAS, IGHE
47alcoholic liver cirrhosis27.6GSTM1, GPT, F2, ALB, CYP2A6, SOD1
48typhus27.5CD40LG, GPT, ALPP, SLC17A5
49hypertriglyceridemia27.5CES1, IL1B, IL6, FAS, GPT, IFNA1
50insulin resistance27.5RETN, CNR1, VDR, BMP6, CD14, CD40LG

Graphical network of the top 20 diseases related to autoimmune hepatitis:



Graphical network of diseases related to autoimmune hepatitis

Clinical Features for Autoimmune Hepatitis

about this section

Drugs & Therapeutics for Autoimmune Hepatitis

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for autoimmune hepatitis

Drug clinical trials:

Search ClinicalTrials for autoimmune hepatitis

Search NIH Clinical Center for autoimmune hepatitis

Search CenterWatch for autoimmune hepatitis

Inferred drug relations via UMLS/NDF-RT:

43 28 astragalus, astragalus extract

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for autoimmune hepatitis:
Autologous hematopoietic stem cell transplantation for treatment of End-Stage Chronic Liver Disease
Umbilical cord-derived mesenchymal stem cells for treatment of hepatitis
Embryonic/Adult Cultured Cells Related to autoimmune hepatitis:
Peripheral blood/mobilized hematopoietic stem cells, PMIDs: 20587151

Genetic Tests for Autoimmune Hepatitis

about this section

Anatomical Context for Autoimmune Hepatitis

about this section
Sources:
21LifeMap Discovery™, 11FMA, 22MalaCards
See all sources

MalaCards organs/tissues related to autoimmune hepatitis:

22
Liver, Kidney, Bone marrow, Pancreas, Myeloid, T cells, B cells

FMA organs/tissues related to autoimmune hepatitis:

11
Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to autoimmune hepatitis:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Bone -> Bone Marrow -> Hematopoietic Stem Cells Potential therapeutic candidate

Phenotypes for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to autoimmune hepatitis:

25 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.4DBT, TBX21, PTPRC, FCGR2B, CD14
2renal/urinary system phenotypeMP:000536710.0DBT, DDC, PTPRC, GOLM1, FCGR2B, FH
3hematopoietic system phenotypeMP:00053979.8KRT8, TBX21, PTPRC, PTPRCAP, GZMB, ASIP
4no phenotypic analysisMP:00030129.4POMC, OPRD1, ACTB, SHANK3, CYP1A2, HLA-C
5endocrine/exocrine gland phenotypeMP:00053799.3GGT1, LTA, CTLA4, CYP1A2, AIRE, IFNG
6skeleton phenotypeMP:00053908.9AMELX, PTPRC, CTLA4, NR3C1, ACTA1, FAS
7digestive/alimentary phenotypeMP:00053818.7TBX21, CTLA4, NR3C1, NOS2, KRT8, CPE
8nervous system phenotypeMP:00036318.2LTA, NR3C1, DDC, TBX21, PTPRC, ABCB7
9integument phenotypeMP:00107718.2CTLA4, NR3C1, SHANK3, DBT, OPRD1, POMC
10liver/biliary system phenotypeMP:00053708.0SOD1, IL6, IL2, FCGR2B, ASIP, ASGR1
11normal phenotypeMP:00028737.7TRB@, HLA-DQB1, AIRE, CADM1, PTPRCAP, PTPRC
12reproductive system phenotypeMP:00053897.1CADM1, TNF, CYP11A1, NOS2, KRT8, ACTB
13growth/size phenotypeMP:00053786.7PDIA3, PHGDH, NR3C1, CYP11A1, PTPRC, TPO
14tumorigenesisMP:00020066.5TNF, PTPRC, TBX21, CYP1A2, NOS2, PHGDH
15vision/eye phenotypeMP:00053916.5TNF, NOS2, LTA, ACTA1, ACTB, SOD1
16immune system phenotypeMP:00053876.4PDIA3, CADM1, HSPG2, F2, IFNG, IL6
17mortality/agingMP:00107686.2KRT18, KRT8, PDLIM3, PDIA3, PHGDH, NOS2
18homeostasis/metabolism phenotypeMP:00053765.2NOS2, AIRE, HMGB1, HSPG2, ALB, F2
19behavior/neurological phenotypeMP:00053864.7NOS2, NR3C1, CYP17A1, CYP11A1, CYP1A2, TNF
20cardiovascular system phenotypeMP:00053854.7NOS2, NR3C1, CTLA4, CYP1A2, DDC, TBX21
21cellular phenotypeMP:00053843.6TBX21, PTPRC, PTPRCAP, TNFSF13B, TNFRSF18, TNF

Publications for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
35PubMed
See all sources

Articles related to autoimmune hepatitis:

(show top 50)    (show all 217)
idTitleAuthorsYearAffiliating Genes
1Characterisation and utility of thiopurine methyltran sferase and thiopurine metabolite measurements in autoimmune hepatitis. (19906459)Hindorf U.... Almer S.H.2010TPMT
2Novel autoimmune hepatitis-specific autoantigens iden tified using protein microarray technology. (19545157)Song Q.... Wu L.2010DUT
3Autoimmune hepatitis, HLA and extended haplotypes. (20933106)Oliveira L.C.... Goldberg A.C.2010TNF, LTA, HLA-DRB1
4SLA/LP/tRNP((Ser)Sec) antigen in autoimmune hepatitis : identification of the native protein in human hepatic cell extract. (19683415)Volkmann M.... Manns M.P.2010SEPSECS
5Autoantibodies to asialoglycoprotein receptor (ASGPR) measured by a novel ELISA--revival of a disease-activity marker in autoimmune hepatitis. (19576873)Hausdorf G.... Klein R.2009ASGR1, ASGR2
6Autoantibodies and their antigens in autoimmune hepat itis. (19675997)Bogdanos D.P.... Vergani D.2009SEPSECS
7Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis. (18773898)Mix H.... Rehermann B.2008SEPSECS
8Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese. (18371160)Umemura T.... Kiyosawa K.2008CTLA4, HLA-DRA, HLA-DRB1
9Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70-74 of the HLA-DRB1 molecule. (18022727)Lim Y.S.... Suh D.J.2008HLA-A, HLA-DQB1, HLA-DRB1
10mRNA expression of T-helper 1, T-helper 2 cytokines in autoimmune hepatitis in childhood. (18533937)Kawashima H.... Bergman K.2008ACTB, IL4, IFNG
11Progress in the diagnosis and treatment of autoimmune hepatitis. (19034254)Czaja A.J.2008SEPSECS
12Fulminant autoimmune hepatitis after successful interferon treatment in an HIV-HCV co-infected patient. (18397566)Coriat R.... Podevin P.2008IFNA1
13Human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis. (18753988)Boyella V.D.... Bergasa N.V.2008POMC, OPRD1
14Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2. (17559153)Longhi M.S.... Vergani D.2007CYP2D6
15Autoimmune hepatitis. Part B: diagnosis. (19072441)Czaja A.J.2007SEPSECS
16Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2. (16530525)Ma Y.... Vergani D.2006CYP2D6
17HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. (17050030)Djilali-Saiah I.... Alvarez F.2006HLA-DQB1, HLA-DRB1, HLA-DRB3
18Clinical significance of HLA DRB103-DRB104 in type 1 autoimmune hepatitis. (17105585)Montano-Loza A.J.... Czaja A.J.2006HLA-DRB1
19Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients. (17722299)Tanwandee T.... Chotiyaputta W.2006HLA-DQA1, HLA-DRB1
20A case of polyglandular autoimmune syndrome type III complicated with autoimmune hepatitis. (16946565)Oki K.... Kohno N.2006SLC17A5
21Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients. (17006990)Teufel A.... Kanzler S.2006HLA-B, SEPSECS, HLA-DRB3
22C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis. (15963758)Esteghamat F.... Zali M.R.2005PTPRC
23Autoimmune hepatitis type 1: safety and efficacy of p rolonged medical therapy. (15998423)Seela S.... Boyer J.L.2005GPT
24Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese. (15683428)Fan L.... Zhong R.2005VDR
25Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population. (15378793)Fan L.Y.... Zhong R.Q.2004CTLA4
26Heterogeneous nuclear ribonucleoprotein A2/B1 identified as an autoantigen in autoimmune hepatitis by proteome analysis. (15188401)Huguet S.... Ballot E.2004HNRNPA2B1
27Characterization of a lipoyl domain-independent B-cell autoepitope on the human branched-chain acyltransferase in primary biliary cirrhosis and overlap syndrome with autoimmune hepatitis. (14768949)Csepregi A.... Strassburg C.P.2003DLAT, DBT
28Pathogenesis of autoimmune hepatitis. (12362577)Vergani D.... Mieli-Vergani G.2002FAS
29Emerging treatments for autoimmune hepatitis. (14561179)Czaja A.J.2002IL2
30Erythema gyratum repens: drug reaction following azathioprine administration in a patient with type I autoimmune hepatitis (12168480)GA1nther R.... FAPlsch U.R.2002TPMT
31Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein. (11983223)Vitozzi S.... Alvarez F.2002CYP2D6, FTCD
32Relationship between type I autoimmune hepatitis and alleles of HLA-DRB1 in Chinese patients of Shanghai area (12392614)Qiu D.... Ma X.2002HLA-DRB1
33Autoimmune hepatitis and overlap syndrome: diagnosis (12233264)Berg P.A.... Klein R.2002AIRE, SEPSECS
34Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis. (11786968)Vogel A.... Manns M.P.2002VDR
35A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens. (12765476)Sugimura T.... Strassburg C.P.2002CYP2D6
36Enhanced intrahepatic inducible nitric oxide synthase expression and nitrotyrosine accumulation in primary biliary cirrhosis and autoimmune hepatitis. (12445411)Sanz-Cameno P.... Moreno-Otero R.2002NOS2
37A bioinformatical approach suggests the function of the autoimmune hepatitis target antigen soluble liver antigen/liver pancreas. (11481605)Kernebeck T.... Grotzinger J.2001SEPSECS, PDXP
38Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB*1301, a marker for pediatric autoimmune hepatitis. (11391541)Fainboim L.... Zelazko M.2001HLA-DRB1
39Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus. (11182227)Goldberg A.C.... Kalil J.2001HLA-DQA1, HLA-DQB1, HLA-DRB1
40Genetic susceptibilities for immune expression and liver cell injury in autoimmune hepatitis. (10807521)Czaja A.J.... Donaldson P.T.2000CTLA4
41Immunoreactivity to various human cytochrome P450 proteins of sera from patients with autoimmune hepatitis, chronic hepatitis B, and chronic hepatitis C. (11204250)Miyakawa H.... Kako M.2000CYP1A2
42Immunoreactivity to cytokeratin 8/18 in patients with soluble liver antigen (SLA) positive autoimmune hepatitis (AIH type 3) is not sufficient for diagnostic use. (10934580)Martin L.... Volkmann M.2000KRT18, KRT8, SEPSECS
43Overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis in two cases. (10833101)Griga T.... May B.2000GPT
44Is severe cryptogenic chronic hepatitis similar to autoimmune hepatitis? (9537867)Kaymakoglu S.... Okten A.1998GPT
45Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. (8942737)Strassburg C.P.... Manns M.P.1996UGT1A
46Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. (8700140)Lecoeur S.... Beaune P.H.1996CYP2C9
47Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. (8551001)Ben Ari Z.... Burroughs A.K.1995TPMT
48Demographics of anti-asialoglycoprotein receptor autoantibodies in autoimmune hepatitis. (8076767)Treichel U.... Freni M.A.1994ASGR2
49Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis. (7858109)Doherty D.G.... Williams R.1994HLA-DQB1, C4A
50Association of autoimmune hepatitis with HLA-Bw54 and DR4 in Japanese patients. (2175292)Seki T.... Ota M.1990HLA-A, HLA-DQB1

Expression for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Hepatitis

Pathways for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
20KEGG, 38Reactome, 41Thomson Reuters, 36QIAGEN, 10EMD Millipore, 34PharmGKB, 37R&D Systems
See all sources

Pathways related to autoimmune hepatitis according to GeneDecks:

(show top 50)    (show all 122)
idPathwayScoreTop Affiliating Genes
1Antigen processing and presentation2010.5HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-C
2MHC class II antigen presentation3810.5HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4
3Cell adhesion molecules (CAMs)2010.5CTLA4, CD28, PTPRC, HLA-DRA, HLA-DPB1, CADM1
4Immune response_NFAT in immune response4110.5HLA-DRB3, CD28, IGHE, HLA-DPB1, HLA-DRB4
5CTLA4 Signaling3610.5HLA-DRB3, CD28, HLA-DRB4, CTLA4, HLA-DQA1, HLA-DRA
6Immune response Antigen presentation by MHC class II1010.5HLA-DPB1, HLA-DQA1, HLA-DRA, HLA-DRB3, HLA-DRB4, TRB@
7Immune response_Antigen presentation by MHC class II4110.4HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB3, HLA-DRB4
8CTL Mediated Apoptosis3610.4HLA-C, HLA-DQB1, HLA-B, HLA-A, HLA-DRA, HLA-DQA1
9Phenytoin Pathway, Pharmacokinetics3410.3CYP2D6, CYP1A2, CYP2C9, UGT1A1, UGT1A6, CYP2B6
10Staphylococcus aureus infection2010.3HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
11CD28 Signaling in T-Helper Cell3610.3HLA-DRB3, CD28, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DQB1
12Immune response NFAT in immune response1010.3HLA-DQB1, HLA-DQA1, HLA-DPB1, CD79A, TRB@, HLA-DRB4
13G-protein signaling N-RAS regulation pathway1010.3HLA-DPB1, TRB@, HLA-DRB4, HLA-DRB3, HLA-DRA, HLA-DRB1
14Immune System3810.2CTLA4, PDIA3, FCGR2B, CIITA, CD79A, IFNG
15G-protein signaling_N-RAS regulation pathway4110.1HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-DQB1, HLA-DRB3, HLA-DRB4
16Viral myocarditis2010.1HLA-DRA, ACTB, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
17Phagosome2010.1HLA-DPB1, HLA-DQA1, HLA-C, CD14, HLA-A, FCGR2B
18Immune response T cell receptor signaling pathway1010.1HLA-DPB1, HLA-DQA1, PTPRC, TRB@, HLA-DRB4, HLA-DRB3
19Immune response_T cell receptor signaling pathway4110.0PTPRC, HLA-DRB4, HLA-DRB3, HLA-DRB1, TRB@, HLA-DQB1
20Drug metabolism - cytochrome P450209.7CYP2C9, CYP1A2, CYP2A6, CYP2B6, CYP2D6, UGT1A1
21Graft-versus-host disease209.6CD28, IL2, HLA-A, HLA-B, HLA-C, HLA-DPB1
22RAR-Gamma-RXR-Alpha Degradation369.5IL2, LTA, TNFSF13B
23ICos-ICosL Pathway in T-Helper Cell369.4HLA-DRA, IL2, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DRB4
24Immune response IL-22 signaling pathway109.4HLA-DPB1, TRB@, HLA-DRB4, HLA-DRB3, CD28, HLA-DRB1
25Immune response_IL-22 signaling pathway419.4HLA-DRA, HLA-DRB3, HLA-DRB1, TRB@, CD28, IL2
26Metabolic pathways209.3ALPP, PGAM1, GGT1, DBT, CES1, FTCD
27Systemic lupus erythematosus209.2C4A, CD28, CD40LG, FCGR2A, TNF, IFNG
28Asthma209.1HLA-DRB4, TNF, HLA-DRB3, HLA-DRB1, HLA-DRA, CD40LG
29Toxoplasmosis208.8IL10, NOS2, CIITA, TNF, HLA-DRB4, HLA-DRB3
30Rheumatoid arthritis208.8IL6, IFNG, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA
31Th1 Differentiation378.6IL2, CD28, LTA, IFNG, HLA-DRA, TNF
32IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types378.6FOXP3, IL10, TNF, IL2, IL2RA, FAS
33Influenza A208.4HLA-DQB1, HLA-DQA1, HLA-DPB1, ACTB, HLA-DRA, HLA-DRB1
34Hematopoietic cell lineage208.3CD14, IL2RA, IL4, IL6, HLA-DRA, HLA-DRB1
35Intestinal immune network for IgA production208.3HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1, IL6
36Autoimmune thyroid disease208.2GZMB, IL10, IL2, IL4, FAS, IFNA1
37Leishmaniasis208.2NOS2, FCGR2A, TNF, HLA-DRB4, HLA-DRB3, HLA-DRB1
38THC Differentiation Pathway368.0HLA-DRB1, CD28, IL10, IL2, IL2RA, IL4
39Type I diabetes mellitus207.9HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB3, HLA-DRB4, TNF
40Allograft rejection207.6CD40LG, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1
41Cytokine Network367.3IL10, IL1B, IL2, IL6, IFNA1, TNF
42Tuberculosis207.3NOS2, TNF, HLA-DRB4, CD14, BAX, CIITA
43MIF Regulation of Innate Immune Cells367.0CXCL10, BMP6, BAX, CD14, IL10, IL1B
44all-trans-Retinoic Acid Signaling in Brain367.0IL1B, IL10, IL2, TNF, TNFSF13B, LTA
45PEDF Induced Signaling367.0CXCL10, LTA, TNFSF13B, TNF, IL6, BMP6
46STAT3 Pathway366.9TNFSF13B, LTA, CXCL10, IL1B, CD28, TNFRSF18
47MIF Mediated Glucocorticoid Regulation366.8BAX, IL10, IL6, LTA, CXCL10, NR3C1
48Cytokine-cytokine receptor interaction206.7TNF, IL1B, IL10, TNFRSF6B, TNFSF13B, LTA
49PAK Pathway366.4TNFSF13B, IL1B, ACTB, CXCL10, BMP6, ACTA1
50Antioxidant Action of Vitamin-C366.0BAX, CD28, IL10, IL1B, IL2, IL2RA

Compounds for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
See all sources

Compounds related to autoimmune hepatitis according to GeneDecks:

(show top 50)    (show all 517)
idCompoundScoreTop Affiliating Genes
1ivig32 10.8SEPSECS, FCGR2B, LTA
2cyclophosphamide32 34 9 9 13.7TRB@, TPMT
3rifampicin32 9.9UGT1A, UGT1A1, UGT1A6, GPT, CYP1A2, CYP2A6
4endotoxin32 9.8RETN, CIITA, CD14, ARG1, F5, HSPD1
5nevirapine32 34 9 9 12.6GPT, HLA-C, CYP1A2, CYP2A6, CYP2B6, CYP2D6
6glutamate32 9.3CNR1, VDR, BMP6, FTCD, CD79A, CDKN3
7ursodeoxycholic acid32 9 18 9 12.3BMP6, CD40LG, GPT, IFNA1, F2, ALPP
8acetaminophen32 34 9 18 9 13.2UGT1A, UGT1A1, UGT1A6, GPT, IGHE, F5
9cysteine32 9.1VDR, CD79A, CD14, CD40LG, GZMB, GSTM1
10antipyrine32 9 9 10.9F5, F2, ALB, HLA-B, CYP1A2, CYP2A6
11ascorbic acid32 18 9.8VDR, CD40LG, GSTM1, GSTT1, IL2RA, FAS
12steroid32 8.5RETN, SEPSECS, CIITA, UGT1A, UGT1A1, CEACAM3
13estrogen32 8.4RETN, VDR, UGT1A, UGT1A1, CEACAM3, CES1
14oxygen32 18 9.4CIITA, BAX, CEACAM3, GZMB, FH, GSTM1
15vegf32 8.4RETN, CEACAM3, CD14, CD40LG, CDKN3, ARG1
16thyroxine32 18 9.2RETN, VDR, CIITA, UGT1A, UGT1A1, CEACAM3
17testosterone32 9 18 9 11.1VDR, UGT1A, UGT1A1, UGT1A6, CES1, CD79A
18tamoxifen32 34 9 9 11.0VDR, BMP6, UGT1A, UGT1A1, UGT1A6, BAX
19atorvastatin32 34 9 18 9 11.8RETN, BMP6, CES1, CD40LG, IL10, IL1RN
20mycophenolate mofetil32 9 9 9.7SEPSECS, UGT1A, UGT1A1, CD79A, CD40LG, IL10
21okt332 7.7BMP6, CD79A, CD40LG, IL10, IL2, IL2RA
22vitamin d32 7.6VDR, BMP6, CD79A, CD14, GSTM1, IL10
23arginine32 7.5CNR1, VDR, UGT1A1, CD79A, CD14, CD40LG
24creatinine32 7.5RETN, VDR, BMP6, CEACAM3, CD79A, CD14
25histamine32 18 8.5CNR1, BMP6, CD79A, CD14, CD40LG, FCGR2A
26rantes32 7.3BMP6, CIITA, CD14, CD40LG, GZMB, IL2
27polyinosinic-polycytidylic acid32 7.3CIITA, IL10, IL2, IL4, IL6, IFNA1
28infliximab32 9 9 9.3IL10, IL1B, IL1RN, IL2RA, IL4, IL6
29methotrexate32 34 42 9 9 11.3BMP6, CEACAM3, CD79A, GSTM1, IL10, IL1B
30simvastatin32 34 42 9 18 9 11.9BMP6, CIITA, CES1, IL10, IL1RN, IL4
31lipid32 6.8RETN, CNR1, VCP, CIITA, CES1, CD28
32pentoxifylline32 9 9 8.4BMP6, CD14, IL10, IL1B, IL1RN, IL2
33tyrosine32 6.2RETN, VCP, BMP6, CIITA, UGT1A1, CEACAM3
34thymidine32 18 7.2VDR, BMP6, CIITA, UGT1A1, CEACAM3, FCGR2B
35herbimycin a32 42 7.2BMP6, CD28, CD14, CD40LG, CDKN3, IL1B
36il 1032 6.1VDR, BMP6, IL10, IL1B, IL1RN, IL2
37neopterin32 6.1CD79A, CD14, CD40LG, GZMB, IL10, IL1B
38alanine32 6.1RETN, CNR1, VDR, BMP6, CIITA, UGT1A1
39nitric oxide32 9 18 9 9.0RETN, BMP6, CIITA, CEACAM3, FOXP3, GZMB
40lactate32 6.0BMP6, CEACAM3, CD79A, CD14, CD40LG, CDKN3
41genistein32 9 18 9 8.9VDR, UGT1A, UGT1A1, BAX, CD28, CD40LG
42serine32 5.8CNR1, SEPSECS, VDR, VCP, BMP6, CIITA
43actinomycin d32 5.6RETN, VDR, CIITA, UGT1A, BAX, CD40LG
44prednisolone32 9 9 7.5BMP6, CD79A, CD14, CDKN3, GZMB, GSTM1
45hydrocortisone32 9 9 7.3BMP6, CD14, IL10, IL1B, IL1RN, IL2
46retinoic acid32 42 18 7.1VDR, BMP6, UGT1A, UGT1A1, UGT1A6, BAX
47cyclosporin a32 42 5.5SEPSECS, VDR, BMP6, CIITA, CD28, CD79A
48indomethacin32 9 9 6.4CNR1, BMP6, UGT1A, UGT1A1, CES1, CD79A
49cycloheximide32 4.1RETN, VDR, BMP6, CIITA, UGT1A, BAX
50dexamethasone32 42 34 9 9 7.3RETN, VDR, BMP6, CIITA, UGT1A, UGT1A1

GO Terms for genes affiliated with Autoimmune Hepatitis

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to autoimmune hepatitis according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:04261310.4HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
2clathrin-coated endocytic vesicle membraneGO:03066910.4HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
3trans-Golgi network membraneGO:03258810.3HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
4transport vesicle membraneGO:03065810.3CPE, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
5endocytic vesicle membraneGO:03066610.3HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
6integral to lumenal side of endoplasmic reticulum membraneGO:07155610.2HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
7ER to Golgi transport vesicle membraneGO:01250710.2HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DQB1, HLA-DQA1
8lysosomal membraneGO:00576510.1SLC17A5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
9MHC class I protein complexGO:0426129.9HLA-C, HLA-B, HLA-A, MICA
10mitochondrial matrixGO:0057599.7DBT, NR3C1, CYP11A1, DLAT, HSPD1, GOT2
11integral to plasma membraneGO:0058878.8HLA-DRB1, HLA-DRB3, HLA-DRB4, TPO, TNF, TNFRSF18
12external side of plasma membraneGO:0098978.7HLA-DRB4, TNF, TNFRSF18, PTPRC, CTLA4, CXCL10
13plasma membraneGO:0058866.3TNFSF13B, TNF, TPO, HLA-DRB4, HLA-DRB3, HLA-DRB1
14extracellular spaceGO:0056154.7POMC, ALB, HSPG2, HSPD1, HMGB1, HMGB2

Biological processes related to autoimmune hepatitis according to GeneDecks:

(show top 50)    (show all 53)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.8HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
2humoral immune response mediated by circulating immunoglobulinGO:00245510.8HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
3inflammatory response to antigenic stimulusGO:00243710.8HLA-DRB4, HLA-DRB3, HLA-DRB1, HMGB1
4regulation of interleukin-10 secretionGO:200117910.8HLA-DRB4, HLA-DRB3, HLA-DRB1
5regulation of interleukin-4 productionGO:03267310.8HLA-DRB4, HLA-DRB3, HLA-DRB1
6detection of bacteriumGO:01604510.7HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-B, HLA-A
7cellular amino acid biosynthetic processGO:00865210.7GPT, GOT1, GOT2, PHGDH
8T cell costimulationGO:03129510.6CTLA4, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
9antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.6HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
10T cell receptor signaling pathwayGO:05085210.5PTPRC, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
11negative regulation of interferon-gamma productionGO:03268910.5HLA-DRB4, HLA-DRB3, HLA-DRB1, IL10, FOXP3
12heterocycle metabolic processGO:04648310.5CYP2D6, CYP1A2, UGT1A1
13negative regulation of T cell proliferationGO:04213010.5FOXP3, IL10, HLA-DRB1, HLA-DRB3, HLA-DRB4
14drug catabolic processGO:04273710.5CYP2C9, CYP2D6, CYP1A2
15cellular nitrogen compound metabolic processGO:03464110.5POMC, DBT, PHGDH, DDC, TPO, GOT2
16drug metabolic processGO:01714410.4CYP2C9, CYP2D6, CYP2B6, CYP2A6, CYP1A2, UGT1A1
17dibenzo-p-dioxin metabolic processGO:01889410.4CYP17A1, CYP11A1, CYP1A2
18exogenous drug catabolic processGO:04273810.4CYP2C9, CYP2B6, CYP2A6, CYP1A2
19monoterpenoid metabolic processGO:01609810.4CYP2C9, CYP2D6, CYP1A2
20steroid metabolic processGO:00820210.4CYP2C9, CYP21A2, CYP17A1, CYP11A1, CYP2D6, CYP2B6
21chronic inflammatory response to antigenic stimulusGO:00243910.2IL1B, IL1RN
22B cell proliferationGO:04210010.2PTPRC, HSPD1, IL10, CD40LG, CD79A
23interferon-gamma-mediated signaling pathwayGO:06033310.0SP100, CIITA, IFNG, HLA-A, HLA-B, HLA-C
24xenobiotic metabolic processGO:00680510.0GGT1, CYP2C9, CYP21A2, CYP17A1, CYP11A1, CYP2D6
25response to gamma radiationGO:0103329.9CXCL10, CYP11A1, PTPRC, IL1B, BAX
26cellular response to lipopolysaccharideGO:0712229.7NFKBIL1, NOS2, CYP17A1, CYP11A1, HMGB2, IFNG
27cell surface receptor signaling pathwayGO:0071669.7CXCL10, PTPRC, F2, IFNG, IL2RA, ASGR2
28positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.7TNF, PTPRC, LTA
29positive regulation of MHC class II biosynthetic processGO:0453489.6IFNG, IL4, IL10, CD40LG, CIITA
30B cell differentiationGO:0301839.6PTPRC, IL4, IL10, CD40LG, CD79A
31virus-host interactionGO:0190489.6KRT18, KRT8, SP100, HLA-C, HLA-B, HLA-A
32transformed cell apoptotic processGO:0069279.6TNF, BAX, FAS
33negative regulation of growth of symbiont in hostGO:0441309.6LTA, TNF, IFNG, IL10
34apoptotic DNA fragmentationGO:0063099.5SOD1, HMGB2, HMGB1, BAX
35positive regulation of calcidiol 1-monooxygenase activityGO:0605599.5IL1B, IFNG, TNF
36positive regulation of fever generationGO:0316229.4CNR1, IL1B, TNF
37humoral immune responseGO:0069599.3LTA, TNF, AIRE, IFNG, IL6, CD28
38positive regulation of isotype switching to IgG isotypesGO:0483049.2TBX21, PTPRC, IFNG, IL4, IL2
39cytokine-mediated signaling pathwayGO:0192219.1HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, SP100
40small molecule metabolic processGO:0442819.1CYP11A1, CYP2D6, CYP2B6, CYP2A6, CYP1A2, DDC
41positive regulation of chemokine biosynthetic processGO:0450809.0IL1B, IL4, IFNG, TNF
42positive regulation of T cell proliferationGO:0421029.0PTPRC, IFNG, IL6, IL4, IL1B, CD28
43positive regulation of apoptotic processGO:0430658.9SOD1, PDIA3, CTLA4, PTPRC, TNF, HMGB1
44response to glucocorticoid stimulusGO:0513848.8TNF, HMGB1, GOT1, FAS, IL6, IL1RN
45positive regulation of interferon-gamma productionGO:0327298.8LTA, TNF, HSPD1, IL2, IL1B, CD40LG
46response to drugGO:0424938.4SOD1, LTA, CYP17A1, CYP11A1, TNF, IFNG
47positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.4SP100, TNF, IL6, IL4, IL1B, IL10
48immune responseGO:0069558.2CTLA4, OPRD1, CXCL10, TNFSF13B, HLA-DRB4, HLA-DRB3
49anti-apoptosisGO:0069168.0SOD1, NR3C1, TNFRSF6B, TNFRSF18, TNF, FAS
50positive regulation of transcription from RNA polymerase II promoterGO:0459446.9IFNG, HMGB1, HMGB2, AIRE, TNF, POMC

Molecular functions related to autoimmune hepatitis according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.5HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1, HLA-DQA1
2oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.2CYP1A2, CYP2A6, CYP2B6
3pyridoxal phosphate bindingGO:03017010.0DDC, ALB, GOT2, GOT1, GPT, SEPSECS
4electron carrier activityGO:0090559.9CYP21A2, CYP2C9, PHGDH, PDIA3, CYP17A1, CYP11A1
5iron ion bindingGO:0055069.5NOS2, CYP2C9, CYP21A2, CYP17A1, CYP11A1, CYP2D6
6heme bindingGO:0200379.5NOS2, CYP2C9, CYP21A2, CYP17A1, CYP11A1, CYP2D6
7receptor bindingGO:0051029.2POMC, CXCL10, LTA, NOS2, TNFSF13B, HLA-B
8growth factor activityGO:0080837.3F2, AMELX, IL6, IL4, IL2, IL1B
9cytokine activityGO:0051256.9BMP6, LTA, TNFSF13B, TNF, HMGB1, IFNG
10protein bindingGO:0055155.4SP100, DDX39B, DDC, DLAT, PTPRC, DUT

Sources for Autoimmune Hepatitis

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z