AIH
MCID: ATM011
MIFTS: 56

Autoimmune Hepatitis (AIH) malady

Gastrointestinal, Liver categories

Summaries for Autoimmune Hepatitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

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NIH Rare Diseases:43 Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. this immune response causes inflammation of the liver, also called hepatitis. the disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. autoimmune hepatitis sometimes occurs in relatives of people with autoimmune diseases, suggesting a genetic cause. this disease is most common in young girls and women. last updated: 6/8/2011

MalaCards: Autoimmune Hepatitis, also known as autoimmune hepatitis with centrilobular necrosis, is related to hepatitis c and hepatitis b. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase), and among its related pathways is Codeine and morphine metabolism. The compounds mycophenolate mofetil and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and liver, and related mouse phenotype hematopoietic system.

Disease Ontology:8 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia:64 Autoimmune Hepatitis is a disease of the liver that occurs when the body\'s immune system attacks cells... more...

Aliases & Classifications for Autoimmune Hepatitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Liver


Characteristics (Orphanet epidemiological data):

49
autoimmune hepatitis:
Inheritance: Sporadic; Prevalence: 1-9/1000000; Age of onset: Adulthood


Aliases & Descriptions:

autoimmune hepatitis 8 43 10 49 31
autoimmune hepatitis with centrilobular necrosis 8
autoimmune chronic active hepatitis 8
chronic autoimmune hepatitis 49
autoimmune chronic hepatitis 43
hepatitis, autoimmune 61
hepatitis autoimmune 45
aih 43


External Ids:

Disease Ontology8 DOID:2048
MeSH35 D019693
ICD9CM27 571.42
NCIt40 C27029
ICD10 via Orphanet26 K75.4
ICD1025 K75.4

Related Diseases for Autoimmune Hepatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hepatitis c family:

hepatitis e hepatitis b
autoimmune hepatitis hepatitis d
hepatitis a hepatitis
viral hepatitis hepatitis c virus

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.9CTLA4, ASGR2, GPT, CYP2D6
2hepatitis b31.5GPT, ASGR2, CTLA4
3primary biliary cirrhosis31.2AIRE, ASGR2, SEPSECS, GPT, CTLA4
4sclerosing cholangitis30.9SEPSECS
5primary sclerosing cholangitis30.8AIRE, GPT
6systemic lupus erythematosus30.7C4A
7arthritis30.5CTLA4
8graves' disease30.1CTLA4, HLA-DRB3, AIRE
9ipex syndrome29.9AIRE, GPT, CYP2D6, HLA-S, C4A
10hepatitis a11.4
11hepatitis d11.1
12hepatitis e11.0
13drug-induced hepatitis10.5
14autoimmune thyroiditis10.4
15celiac disease10.4
16thyroiditis10.4
17hepatitis c virus10.4
18mixed connective tissue disease10.3
19ulcerative colitis10.3
20viral hepatitis10.3
21autoimmune thrombocytopenic purpura10.3
22autoimmune hemolytic anemia10.3
23adult-onset still's disease10.3
24polymyositis10.3
25acute liver failure10.2
26conn's syndrome10.2
27n syndrome10.2
28bernard-soulier syndrome10.2
29crohn's disease10.2
30visceral leishmaniasis10.2
31polyarteritis nodosa10.2
32thrombocytopenia10.2
33thymoma10.2
34char syndrome10.2
35membranous glomerulonephritis10.1
36evans' syndrome10.1
37epstein-barr virus hepatitis10.1
38pyoderma gangrenosum10.1
39osteoporosis10.1
40autoimmune polyendocrine syndrome10.1
41vasculitis10.1
42hypothyroidism, autoimmune10.1
43hepatitis b virus infection10.1
44amelogenesis imperfecta hypomaturation type10.0
45galactosemia10.0TPMT, GPT, CYP2D6, ASGR2, CTLA4, SEPSECS
46hepatitis10.0ASGR2, ARG1, SEPSECS, GPT
47diabetes mellitus10.0AIRE, GPT, CTLA4
48rheumatoid arthritis10.0CTLA4, TPMT, TNFRSF6B
49congenital generalized lipodystrophy type 310.0GPT, SEPSECS, ASGR2
50hepatocellular carcinoma10.0CTLA4, ASGR2, GPT, ARG1, TNFRSF6B

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to autoimmune hepatitis

Clinical Features for Autoimmune Hepatitis

Drugs & Therapeutics for Autoimmune Hepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Hepatitis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Hepatitis

Search NIH Clinical Center for Autoimmune Hepatitis

Search CenterWatch for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

Sources:
31LifeMap Discovery™, 33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Autoimmune Hepatitis:

33
Skin, Liver, Kidney, Lymph node, Spleen, Bone marrow, Heart, Smooth muscle, Pancreas, Thyroid, Myeloid, T cells, B cells

FMA organs/tissues related to Autoimmune Hepatitis:

14
Liver

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autoimmune Hepatitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.6TPMT, ASGR2, ASIP, ASGR1, PTPRCAP, AIRE

Publications for Autoimmune Hepatitis

Sources:
51PubMed
See all sources

Articles related to Autoimmune Hepatitis:

(show top 50)    (show all 882)
idTitleAuthorsYear
1
Co-development of autoimmune hepatitis and SjAPgren's syndrome triggered by the administration of herbal medicines. (24133669)
2013
2
Autoimmune hepatitis associated with leprosy in a child. (22331015)
2013
3
Autoimmune hepatitis in association with ramelteon. (23632362)
2013
4
Combination Therapy of Ursodeoxycholic Acid and Corticosteroids for Primary Biliary Cirrhosis with Features of Autoimmune Hepatitis: A Meta-Analysis. (24369456)
2013
5
Review article: autoimmune hepatitis -- current management and challenges. (24010812)
2013
6
Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence. (22345339)
2012
7
Histopathology of de novo autoimmune hepatitis. (22378542)
2012
8
Nonstandard drugs and feasible new interventions for autoimmune hepatitis: part I. (22563779)
2012
9
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1. (22187167)
2012
10
Immunohistochemical phenotyping of the inflammatory infiltrate in de novo autoimmune hepatitis after liver transplantation in children. (22672703)
2012
11
Autoimmunity in inflammatory bowel disease: a case of ulcerative colitis with diabetes mellitus, autoimmune hepatitis and autoimmune hypothyroidism. (23692793)
2012
12
Autoimmune hepatitis and hepatic arteritis. (22554732)
2012
13
Autoantibody-negative autoimmune hepatitis. (22187100)
2012
14
Autoimmune hepatitis: current knowledge. (22521122)
2012
15
Drug choices in autoimmune hepatitis: part B--Nonsteroids. (23061712)
2012
16
SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection. (22829702)
2012
17
Antimitochondrial antibody -M2 positive autoimmune hepatitis during standard of care for chronic hepatitis C. (22443693)
2012
18
De novo autoimmune hepatitis associated with PTH(1-34) and PTH(1-84) administration for severe osteoporosis in a liver transplant patient. (22120908)
2012
19
Performance parameters of the conventional serological markers for autoimmune hepatitis. (21127976)
2011
20
Proposal of autoimmune hepatitis presenting with acute hepatitis, severe hepatitis and acute liver failure. (21554505)
2011
21
Autoimmune hepatitis and antigen-specific T regulatory cells: when can we send in the regulators? (21274860)
2011
22
Warm autoimmune haemolytic anaemia and autoimmune hepatitis in an asymptomatic carrier of hepatitis B virus. (22204196)
2011
23
Coinfection of hepatitis A virus genotype IA and IIIA complicated with autoimmune hemolytic anemia, prolonged cholestasis, and false-positive immunoglobulin M anti-hepatitis E virus: a case report. (22310798)
2011
24
Evaluation of risk factors for the development of cirrhosis in autoimmune hepatitis: Japanese NHO-AIH prospective study. (21042923)
2011
25
Genetic background of autoimmune hepatitis in Japan. (20957499)
2011
26
Ornidazole-induced autoimmune hepatitis. (22234756)
2011
27
A case of adult autoimmune hepatitis with histological features of giant cell hepatitis. (21325763)
2011
28
Pregnancy outcome in women with autoimmune hepatitis. (20577751)
2011
29
Systemic lupus erythematosus and autoimmune hepatitis. (20665028)
2011
30
Autoimmune hepatitis. (21167232)
2011
31
Another cause of autoimmune hepatitis. (20578154)
2010
32
A Case of Autoimmune Hepatitis Treated with Rituximab. (21151634)
2010
33
Psychological stress is associated with relapse in type 1 autoimmune hepatitis. (20849437)
2010
34
Alpers syndrome presenting with anatomopathological features of fulminant autoimmune hepatitis. (20582478)
2010
35
Treatment response in patients with autoimmune hepatitis. (20815018)
2010
36
The development of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome during the course of connective tissue diseases: report of three cases and review of the literature. (19826950)
2010
37
Significant association of HLA-DQ5 with autoimmune hepatitis in Taiwan. (18194915)
2007
38
Autoimmune hemolytic anemia in an infant with giant cell hepatitis. (16493610)
2006
39
Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation. (15838910)
2005
40
Gastric autoimmune disorders in patients with chronic hepatitis C before, during and after interferon-alpha therapy. (12854147)
2003
41
Autoimmune hepatitis and overlap syndrome: therapy]. (12233265)
2002
42
Peripheral B-cell CD5 expansion and CD81 overexpression and their association with disease severity and autoimmune markers in chronic hepatitis C virus infection. (11985527)
2002
43
Pathogenesis of autoimmune hepatitis. (12362577)
2002
44
Autoimmune hepatitis and overlap syndrome: diagnosis]. (12233264)
2002
45
A major CYP2D6 autoepitope in autoimmune hepatitis type 2 and chronic hepatitis C is a three-dimensional structure homologous to other cytochrome P450 autoantigens. (12765476)
2002
46
Glutathione-S-Transferase M1 null genotype in autoimmune hepatitis. (11680579)
2001
47
Increase in CD95 (Fas/APO-1)-positive CD4+ and CD8+ T cells in peripheral blood derived from patients with autoimmune hepatitis or chronic hepatitis C with autoimmune phenomena. (10719750)
2000
48
Anti asialoglycoprotein receptor antibodies and soluble interleukin-2 receptor levels as marker for inflammation in autoimmune hepatitis. (9123953)
1997
49
Autoimmune mechanisms in chronic hepatitis B and delta virus infections. (8590155)
1995
50
Case of mixed connective tissue disease associated with autoimmune hepatitis. (3180986)
1988

Genetic Variations for Autoimmune Hepatitis

Expression for genes affiliated with Autoimmune Hepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for genes affiliated with Autoimmune Hepatitis

Sources:
38NCBI BioSystems Database, 50PharmGKB
See all sources

Pathways related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5CYP2D6, CYP2D7P1

Compounds for genes affiliated with Autoimmune Hepatitis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1mycophenolate mofetil45 50 1112.8CTLA4, GPT, SEPSECS, TPMT
2cyclosporin a45 29 6012.8TPMT, GPT, HLA-S, CTLA4, SEPSECS
3Pyridoxal Phosphate1110.8PDXP, SEPSECS, GPT, FTCD
4methotrexate45 50 1112.8CTLA4, HLA-S, GPT, TPMT
5steroid4510.7TPMT, SEPSECS, CYP2D6, C4A, CTLA4
6perhexiline45 1111.7CYP2D6, TPMT
7bupivacaine45 29 1112.7GPT, CYP2D6
8efavirenz45 50 1112.6GPT, CYP2D6
96 mercaptopurine4510.5TPMT, GPT
10pyridoxal45 11 2412.5PDXP, GPT
11thiopurine4510.4CYP2D6, TPMT
12nevirapine45 50 1112.2GPT, CYP2D6

GO Terms for genes affiliated with Autoimmune Hepatitis

Sources:
16Gene Ontology
See all sources

Molecular functions related to Autoimmune Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asialoglycoprotein receptor activityGO:00487310.5ASGR2, ASGR1

Products for genes affiliated with Autoimmune Hepatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Hepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet