AIED
MCID: ATM021
MIFTS: 32

Autoimmune Inner Ear Disease (AIED) malady

Rare diseases, Ear diseases categories

Summaries for Autoimmune Inner Ear Disease

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Autoimmune inner ear disease is a suspected autoimmune disease characterized by rapidly progressive... more...

MalaCards: Autoimmune Inner Ear Disease, also known as AIED, is related to coronary artery disease and influenza. An important gene associated with Autoimmune Inner Ear Disease is COCH (cochlin), and among its related pathways are Parkin-Ubiquitin Proteasomal System pathway and Allograft rejection. The compounds delta-12-pgj2 and geranylgeranylacetone have been mentioned in the context of this disorder. Affiliated tissues include lung and testes.

Aliases & Classifications for Autoimmune Inner Ear Disease

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Sources:
44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Ear diseases


Aliases & Descriptions:

autoimmune inner ear disease 44
aied 44


Related Diseases for Autoimmune Inner Ear Disease

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Autoimmune Inner Ear Disease:



Diseases related to autoimmune inner ear disease

Symptoms for Autoimmune Inner Ear Disease

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Drugs & Therapeutics for Autoimmune Inner Ear Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Autoimmune Inner Ear Disease

Drug clinical trials:

Search ClinicalTrials for Autoimmune Inner Ear Disease

Search NIH Clinical Center for Autoimmune Inner Ear Disease

Search CenterWatch for Autoimmune Inner Ear Disease

Genetic Tests for Autoimmune Inner Ear Disease

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Anatomical Context for Autoimmune Inner Ear Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Autoimmune Inner Ear Disease:

34
Lung, Testes

Animal Models for Autoimmune Inner Ear Disease or affiliated genes

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Publications for Autoimmune Inner Ear Disease

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53PubMed
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Articles related to Autoimmune Inner Ear Disease:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. (23912888)
2013
2
Autoimmune inner ear disease: a retrospective review of forty-seven patients. (23817208)
2013
3
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. (23800807)
2013
4
Infliximab for autoimmune inner ear disease: case report and literature review. (24125068)
2013
5
Cogan's syndrome: an autoimmune inner ear disease. (22846458)
2013
6
Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach. (20523038)
2011
7
Autoimmune inner ear disease in children. (21178803)
2011
8
IL-1I^ is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. (21199898)
2011
9
Cochlear implantation in patients with autoimmune inner ear disease including cogan syndrome: a comparison with age- and sex-matched controls. (21082747)
2010
10
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. (19395984)
2009
11
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. (19365153)
2009
12
Immunosuppressive therapy for autoimmune inner ear disease. (19885385)
2009
13
The diagnosis of autoimmune inner ear disease: evidence and critical pitfalls. (18777037)
2009
14
Autoimmune inner ear disease: clinical and laboratory findings and treatment outcome. (19128599)
2008
15
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. (16552463)
2007
16
Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study. (16151336)
2005
17
Autoimmune inner ear disease. (15377956)
2004
18
Autoimmune inner ear disease: diagnostic and therapeutic approaches in a multidisciplinary setting. (12940706)
2003
19
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease. (11913688)
2002
20
Autoimmune inner ear disease: diagnostic and advanced treatments. (12528256)
2002
21
Clinical and experimental studies of autoimmune inner ear disease. (12211349)
2002
22
Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease. (11876599)
2002
23
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. (11568667)
2001
24
Autoimmune inner ear disease: steroid and cytotoxic drug therapy. (11816893)
2001
25
Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. (11122295)
2000
26
Sudden hearing loss and autoimmune inner ear disease. (10976497)
2000
27
Experimental autoimmune inner ear disease: an electrocochleographic and histophysiologic study. (10823474)
2000
28
Autoimmune inner ear disease. (11123055)
2000
29
Utility of laboratory testing in autoimmune inner ear disease. (10569401)
1999
30
Sulfoglucuronosyl glycolipids as putative antigens for autoimmune inner ear disease. (9628451)
1998
31
Plasmapheresis in autoimmune inner ear disease: long-term follow-up. (9303152)
1997
32
You're the flight surgeon: autoimmune inner ear disease. (9441590)
1997
33
Autoimmune inner ear disease--a real entity? (9316775)
1997
34
Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. (8583855)
1996
35
Myelin protein Po as a potential autoantigen in autoimmune inner ear disease. (9002556)
1996
36
Autoimmune inner ear disease. (8649900)
1996
37
An observation on otoacoustic emission and ultrastructure of cochlea in experimental autoimmune inner ear disease. (9206068)
1996
38
The MRL-lpr/lpr mouse: a potential model of autoimmune inner ear disease. (8475729)
1993
39
Azathioprine in combination with steroids in the treatment of autoimmune inner-ear disease. (8112477)
1993
40
Biological and clinical aspects of autoimmune inner ear disease. (1509781)
1992
41
Autoimmune inner ear disease: fact or fantasy? (1927721)
1991
42
Autoimmune inner ear disease and ulcerative colitis. (2026952)
1991
43
Autoimmune inner ear disease: a review of basic mechanisms and clinical correlates. (1870168)
1991
44
Autoimmune inner ear disease: results of therapy. (1927720)
1991
45
Theoretical and practical implications for plasmapheresis in autoimmune inner ear disease. (2811552)
1989
46
Experimental autoimmune inner ear disease. (2643744)
1989
47
Autoimmune inner ear disease: therapy. (2750868)
1989
48
Effect of anti-inflammatory drugs on collagen-induced autoimmune inner ear disease. (3281543)
1988
49
Practical versus theoretical management of autoimmune inner ear disease. (6374341)
1984
50
Antibody activity in perilymph from rats with type II collagen-induced autoimmune inner ear disease. (6435494)
1984

Variations for Autoimmune Inner Ear Disease

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Expression for genes affiliated with Autoimmune Inner Ear Disease

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Inner Ear Disease

Search GEO for disease gene expression data for Autoimmune Inner Ear Disease.

Pathways for genes affiliated with Autoimmune Inner Ear Disease

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN
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Compounds for genes affiliated with Autoimmune Inner Ear Disease

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Autoimmune Inner Ear Disease according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1delta-12-pgj2469.6HSPA4, HSPA8
2geranylgeranylacetone469.6HSPA4, HSPA8
3cyclopentenone469.6HSPA4, HSPA8
4cdcl2469.6HSPA8, HSPA4
5phenylbutyrate469.6HSPA4, HSPA8
68-oxo-dg469.6HSPA4, HSPA8
7manumycin469.6HSPA8, HSPA4
8radicicol46 62 1211.6HSPA4, HSPA8
917-(allylamino)-17-demethoxygeldanamycin469.6HSPA4, HSPA8
10sodium arsenite469.6HSPA8, HSPA4
113-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.6HSPA4, HSPA8
12rotenone469.6HSPA4, HSPA8
13manganese superoxide469.6HSPA8, HSPA4
14salicylic acid46 3010.5HSPA4, HSPA8
15cadmium46 2510.5HSPA4, HSPA8
164-hydroxynonenal46 2510.5HSPA8, HSPA4
17silver469.5HSPA8, HSPA4
18adpribose469.5HSPA4, HSPA8
19geldanamycin46 52 62 1212.5HSPA4, HSPA8
20alpha tocopherol469.5HSPA8, HSPA4
21sodium nitroprusside469.5HSPA4, HSPA8
22mannitol46 1210.5HSPA4, HSPA8
23adriamycin469.5HSPA8, HSPA4
24mg 13246 6210.5HSPA4, HSPA8
25agarose469.5HSPA4, HSPA8
26herbimycin a46 6210.5HSPA8, HSPA4
27quercetin46 62 25 1212.5HSPA4, HSPA8
28curcumin469.5HSPA4, HSPA8
29arsenite46 2510.5HSPA8, HSPA4
30prostaglandin469.5HSPA4, HSPA8
31glycerol46 25 1211.5HSPA4, HSPA8
32polyacrylamide469.5HSPA8, HSPA4
33n acetylcysteine469.5HSPA4, HSPA8
34butyrate469.4HSPA4, HSPA8
35methionine469.4HSPA8, HSPA4
36nmda46 3010.4HSPA4, HSPA8
37acetylcholine46 52 30 25 1213.4HSPA4, HSPA8
38doxorubicin46 52 1211.4HSPA8, HSPA4
39potassium46 25 1211.4HSPA4, HSPA8
40paraffin469.4HSPA4, HSPA8
41glutamine469.4HSPA8, HSPA4
42iron46 2510.3HSPA4, HSPA8
43hydrogen46 2510.3HSPA4, HSPA8
44fatty acid469.3HSPA8, HSPA4
45lactate469.2HSPA4, HSPA8
46dopamine46 30 25 1212.2HSPA4, HSPA8
47superoxide46 2510.1HSPA8, HSPA4
48heparin46 30 25 1212.1HSPA4, HSPA8
49sodium46 2510.0HSPA4, HSPA8
50creatinine468.8HSPA4, HSPA8

GO Terms for genes affiliated with Autoimmune Inner Ear Disease

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Sources:
17Gene Ontology
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Biological processes related to Autoimmune Inner Ear Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to unfolded proteinGO:0069869.1HSPA4, HSPA8

Products for genes affiliated with Autoimmune Inner Ear Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Inner Ear Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet