AIED
MCID: ATM021
MIFTS: 31

Autoimmune Inner Ear Disease (AIED) malady

Categories: Rare diseases, Ear diseases

Aliases & Classifications for Autoimmune Inner Ear Disease

Aliases & Descriptions for Autoimmune Inner Ear Disease:

Name: Autoimmune Inner Ear Disease 50
Ocular Albinism, Type Ii 69
Aied 50

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Ear diseases


Summaries for Autoimmune Inner Ear Disease

MalaCards based summary : Autoimmune Inner Ear Disease, also known as ocular albinism, type ii, is related to androgen insensitivity and amelogenesis imperfecta. An important gene associated with Autoimmune Inner Ear Disease is MPO (Myeloperoxidase), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and NF-kappaB Signaling. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung and testes, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Wikipedia : 71 Autoimmune inner ear disease (AIED) was first defined by Dr. Brian McCabe in a landmark paper describing... more...

Related Diseases for Autoimmune Inner Ear Disease

Diseases related to Autoimmune Inner Ear Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 androgen insensitivity 11.7
2 amelogenesis imperfecta 11.7
3 aland island eye disease 11.5
4 adolescent idiopathic scoliosis 11.1
5 hereditary amyloidosis 11.1
6 pediatric arterial ischemic stroke 10.9
7 amelogenesis imperfecta, type ib 10.9
8 amish infantile epilepsy syndrome 10.7
9 aortic valve insufficiency 10.7
10 amelogenesis imperfecta, type 1e 10.7
11 inner ear disease 10.7
12 cerebritis 10.2
13 amyloidosis 10.1
14 neuronitis 10.1
15 alzheimer disease 10.1
16 atherosclerosis 10.0
17 artery disease 10.0
18 cerebral amyloid angiopathy 10.0
19 dementia 10.0
20 adenocarcinoma 10.0
21 coronary artery disease 10.0
22 labyrinthitis 10.0
23 mirizzi syndrome 10.0 MPO TNF
24 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.0 MPO TNF
25 uveitis 9.9 MPO TNF
26 parkinson disease 11 9.9 MPO TNF
27 dermatomycosis 9.9 MPO TNF
28 scalp dermatosis 9.9 MPO TNF
29 grix blankenship peterson syndrome 9.9 MPO TNF
30 astrocytoma 9.9 MPO TNF
31 endotheliitis 9.9
32 adenocarcinoma in situ 9.9
33 crohn's colitis 9.9 MPO TNF
34 urticaria 9.9 MPO TNF
35 strawberry gallbladder 9.9 MPO TNF
36 pericholangitis 9.9 MPO TNF
37 chordoid meningioma 9.9 MPO TNF
38 fasciitis 9.9 MPO TNF
39 familial renal papillary carcinoma 9.9 MPO TNF
40 bacterial meningitis 9.9 MPO TNF
41 bare lymphocyte syndrome, type i 9.9 MPO TNF
42 idiopathic scoliosis 9.9
43 scoliosis 9.9
44 uterine ligament clear cell adenocarcinoma 9.9 MPO TNF
45 acute kidney failure 9.9 MPO TNF
46 biliary cirrhosis, primary, 2 9.9 MPO TNF
47 acute chest syndrome 9.9 MPO TNF
48 chronic lymphocytic leukemia 9.9 MPO TNF
49 eating disorder 9.9 MPO TNF
50 major depressive disorder and accelerated response to antidepressant drug treatment 9.9 MPO TNF

Graphical network of the top 20 diseases related to Autoimmune Inner Ear Disease:



Diseases related to Autoimmune Inner Ear Disease

Symptoms & Phenotypes for Autoimmune Inner Ear Disease

GenomeRNAi Phenotypes related to Autoimmune Inner Ear Disease according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.23 CACNA1F
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.23 CACNA1F
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.23 CACNA1F
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.23 MPO
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.23 CACNA1F
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.23 CACNA1F MPO
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.23 CACNA1F

Drugs & Therapeutics for Autoimmune Inner Ear Disease

Drugs for Autoimmune Inner Ear Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
3
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
4
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Antirheumatic Agents Phase 3,Phase 1,Phase 2
7 Folic Acid Antagonists Phase 3
8 Nucleic Acid Synthesis Inhibitors Phase 3
9 Dermatologic Agents Phase 3
10 Vitamin B Complex Phase 3
11 Immunosuppressive Agents Phase 3
12 Antimetabolites Phase 3
13 Antimetabolites, Antineoplastic Phase 3
14 Folate Nutraceutical Phase 3
15 Vitamin B9 Nutraceutical Phase 3
16 Pharmaceutical Solutions Phase 2
17 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2
18 Immunoglobulins Phase 2
19 Antibodies, Monoclonal Phase 2
20 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Autoimmunity in Inner Ear Disease Terminated NCT00000361 Phase 3
2 A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease Completed NCT01267994 Phase 1, Phase 2
3 The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease Completed NCT01950312 Phase 2
4 Intratympanic Injection for Autoimmune Inner Ear Disease Terminated NCT01526174 Phase 1, Phase 2
5 Pilot Study of Raptiva to Treat Sjogren's Syndrome Terminated NCT00344448 Phase 2
6 Effects of Vestibular Rehabilitation on MS-related Fatigue: a Randomized Control Trial Completed NCT01216137
7 Quantified Balance Measures During Stance and Gait: Multiple Sclerosis Patients. A Longitudinal Clinical Study Recruiting NCT02142946
8 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
9 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
10 Strength Training on Pancreatic Cancer Withdrawn NCT01395563

Search NIH Clinical Center for Autoimmune Inner Ear Disease

Genetic Tests for Autoimmune Inner Ear Disease

Anatomical Context for Autoimmune Inner Ear Disease

MalaCards organs/tissues related to Autoimmune Inner Ear Disease:

39
Lung, Testes

Publications for Autoimmune Inner Ear Disease

Articles related to Autoimmune Inner Ear Disease:

(show top 50) (show all 67)
id Title Authors Year
1
Autoimmune inner ear disease in a melanoma patient treated with pembrolizumab. ( 26885370 )
2016
2
Paraneoplastic syndrome: a masquerade of autoimmune inner ear disease. ( 25427223 )
2015
3
N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients. ( 26392121 )
2015
4
Current understanding of the pathogenesis of autoimmune inner ear disease: a review. ( 25847404 )
2015
5
Systematic Review of Treatments for Autoimmune Inner Ear Disease. ( 26485595 )
2015
6
Diffuse systemic sclerosis presenting as Meniere's disease-like symptoms as part of autoimmune inner ear disease. ( 26040060 )
2015
7
Progression of autoimmune inner ear disease to labyrinthitis ossificans: clinical and radiologic correlation. ( 25738715 )
2015
8
IL-1I^ inhibition in autoimmune inner ear disease: can you hear me now? ( 25133418 )
2014
9
Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. ( 25133431 )
2014
10
An open label study to evaluate the safety and efficacy of intratympanic golimumab therapy in patients with autoimmune inner ear disease. ( 25203561 )
2014
11
Cochlin in autoimmune inner ear disease: Is the search for an inner ear autoantigen over? ( 25199741 )
2014
12
Cogan's syndrome: an autoimmune inner ear disease. ( 22846458 )
2013
13
Autoimmune inner ear disease: a retrospective review of forty-seven patients. ( 23817208 )
2013
14
Infliximab for autoimmune inner ear disease: case report and literature review. ( 24125068 )
2013
15
Autoimmune inner ear disease preliminary case report: audiometric findings following steroid treatments. ( 23800807 )
2013
16
Innate immune recognition of molds and homology to the inner ear protein, cochlin, in patients with autoimmune inner ear disease. ( 23912888 )
2013
17
Autoimmune inner ear disease in children. ( 21178803 )
2011
18
High dose combination pertussis toxin induces autoimmune inner ear disease in Sprague-Dawley rats. ( 21366505 )
2011
19
IL-1I^ is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. ( 21199898 )
2011
20
Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach. ( 20523038 )
2011
21
Labyrinthitis ossificans secondary to autoimmune inner ear disease: a previously unreported condition. ( 20416474 )
2010
22
Cochlear implantation in patients with autoimmune inner ear disease including cogan syndrome: a comparison with age- and sex-matched controls. ( 21082747 )
2010
23
Induction of tolerance by oral administration of beta-tubulin in an animal model of autoimmune inner ear disease. ( 19365153 )
2009
24
The diagnosis of autoimmune inner ear disease: evidence and critical pitfalls. ( 18777037 )
2009
25
Safety of high-dose corticosteroids for the treatment of autoimmune inner ear disease. ( 19395984 )
2009
26
Immunosuppressive therapy for autoimmune inner ear disease. ( 19885385 )
2009
27
Does the serological study for viral infection in autoimmune inner ear disease make sense? ( 18235201 )
2008
28
Autoimmune inner ear disease: clinical and laboratory findings and treatment outcome. ( 19128599 )
2008
29
Recurrent autoimmune inner ear disease (AIED) and polyarteritis nodosa in a patient with large cell lung carcinoma. ( 16552463 )
2007
30
Etanercept treatment for autoimmune inner ear disease: results of a pilot placebo-controlled study. ( 16151336 )
2005
31
Radiology quiz case 1. Autoimmune inner ear disease (AIED). ( 15967892 )
2005
32
Autoimmune inner ear disease. ( 15377956 )
2004
33
Autoimmune inner ear disease: diagnostic and therapeutic approaches in a multidisciplinary setting. ( 12940706 )
2003
34
Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease. ( 11913688 )
2002
35
Relationship between three inner ear antigens with different molecular weights and autoimmune inner ear disease. ( 11876599 )
2002
36
Autoimmune inner ear disease: diagnostic and advanced treatments. ( 12528256 )
2002
37
Clinical and experimental studies of autoimmune inner ear disease. ( 12211349 )
2002
38
COCH5B2 is a target antigen of anti-inner ear antibodies in autoimmune inner ear diseases. ( 11568667 )
2001
39
Autoimmune inner ear disease: steroid and cytotoxic drug therapy. ( 11816893 )
2001
40
Identification of beta-actin as a candidate autoantigen in autoimmune inner ear disease. ( 11122295 )
2000
41
[The role of heat shock protein 70 and its autoantibody in experimental autoimmune inner ear disease]. ( 12768679 )
2000
42
Sudden hearing loss and autoimmune inner ear disease. ( 10976497 )
2000
43
Autoimmune inner ear disease. ( 11123055 )
2000
44
Experimental autoimmune inner ear disease: an electrocochleographic and histophysiologic study. ( 10823474 )
2000
45
Utility of laboratory testing in autoimmune inner ear disease. ( 10569401 )
1999
46
Sulfoglucuronosyl glycolipids as putative antigens for autoimmune inner ear disease. ( 9628451 )
1998
47
Autoimmune inner ear disease--a real entity? ( 9316775 )
1997
48
Plasmapheresis in autoimmune inner ear disease: long-term follow-up. ( 9303152 )
1997
49
You're the flight surgeon: autoimmune inner ear disease. ( 9441590 )
1997
50
Guinea pig inner ear antigens: extraction and application to the study of human autoimmune inner ear disease. ( 8583855 )
1996

Variations for Autoimmune Inner Ear Disease

Expression for Autoimmune Inner Ear Disease

Search GEO for disease gene expression data for Autoimmune Inner Ear Disease.

Pathways for Autoimmune Inner Ear Disease

GO Terms for Autoimmune Inner Ear Disease

Biological processes related to Autoimmune Inner Ear Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.16 MPO TNF
2 defense response GO:0006952 8.96 MPO TNF
3 negative regulation of growth of symbiont in host GO:0044130 8.62 MPO TNF

Sources for Autoimmune Inner Ear Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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