ALPS1A
MCID: ATM006
MIFTS: 71

Autoimmune Lymphoproliferative Syndrome (ALPS1A) malady

Categories: Genetic diseases, Rare diseases, Blood diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Autoimmune Lymphoproliferative Syndrome

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 37MedGen, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet, 70UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Autoimmune Lymphoproliferative Syndrome:

Name: Autoimmune Lymphoproliferative Syndrome 52 11 23 48 24 25 54 27 50 39 13 68
Canale-Smith Syndrome 11 23 48 24 25 54 70
Alps 11 23 48 24 25 54
Autoimmune Lymphoproliferative Syndrome, Type Ia 52 24 12 68
Autoimmune Lymphoproliferative Syndrome, Type Ib 52 24 68
Autoimmune Lymphoproliferative Syndrome Type Ib 70 27
Autoimmune Lymphoproliferative Syndrome Type Ia 70 27
Fas Deficiency 48 54
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant 48
 
Autoimmune Lymphoproliferative Syndrome 1b 70
Autoimmune Lymphoproliferative Syndrome 1a 70
Alps Ia 24
Alps Ib 24
Alps 1b 24
Alps 1a 24
Alps1b 70
Alps1a 70
Css 70

Characteristics:

Orphanet epidemiological data:

54
autoimmune lymphoproliferative syndrome:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: All ages

HPO:

64
autoimmune lymphoproliferative syndrome:
Inheritance: autosomal dominant inheritance

GeneReviews:

23
Penetrance: alps-fas. a distinction needs to be made between the penetrance of the cellular phenotype (defective fas-mediated apoptosis) and the penetrance of the clinical phenotype (i.e., alps)...


Classifications:



External Ids:

OMIM52 601859
Disease Ontology11 DOID:6688
ICD1030 D47.9, D89.82
ICD9CM32 279.41
MeSH39 D056735
NCIt45 C37864
SNOMED-CT62 702444009
Orphanet54 ORPHA3261
MESH via Orphanet40 D056735
UMLS via Orphanet69 C1328840
ICD10 via Orphanet31 D47.9

Summaries for Autoimmune Lymphoproliferative Syndrome

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NIH Rare Diseases:48 Autoimmune lymphoproliferative syndrome (alps) is a disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). this results in the overproduction of lymphocytes, which build up and cause enlargement of the lymph nodes, liver and spleen. affected individuals have an increased risk of developing cancer of the immune system cells (lymphoma) and may be at increased risk for other cancers. they can also have a variety of autoimmune disorders, most of which damage the blood cells. some of the autoimmune disorders associated with alps can also damage the kidneys, liver, eyes, nerves, or connective tissues. other signs and symptoms may include skin rashes, panniculitis, arthritis, inflammation of blood vessels (vasculitis), mouth sores, premature ovarian failure, and the development of neurological damage. alps is caused by mutations in the fas gene in about 75% of cases. it is usually inherited in an autosomal dominant manner, although a small number of cases are inherited in an autosomal recessive manner. some cases are also believed to arise from a mutation in the lymphocytes that is not inherited, but instead occurs during the course of an individual's lifetime. this type of alteration is called a somatic mutation. treatment may include steroids or other medications, blood transfusions, and/or splenectomy depending on the severity of the disorder. last updated: 8/16/2016

MalaCards based summary: Autoimmune Lymphoproliferative Syndrome, also known as canale-smith syndrome, is related to hepatitis and autoimmune lymphoproliferative syndrome, type ii, and has symptoms including urticaria, splenomegaly and eosinophilia. An important gene associated with Autoimmune Lymphoproliferative Syndrome is FASLG (Fas Ligand), and among its related pathways are Nanoparticle triggered regulated necrosis and African trypanosomiasis. Affiliated tissues include spleen, liver and lymph node, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and pigmentation.

Disease Ontology:11 A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

Genetics Home Reference:25 Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). ALPS is characterized by the production of an abnormally large number of lymphocytes (lymphoproliferation). Accumulation of excess lymphocytes results in enlargement of the lymph nodes (lymphadenopathy), the liver (hepatomegaly), and the spleen (splenomegaly).

OMIM:52 Autoimmune lymphoproliferative syndrome is a heritable disorder of apoptosis, resulting in the accumulation of... (601859) more...

UniProtKB/Swiss-Prot:70 Autoimmune lymphoproliferative syndrome 1A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Wikipedia:71 Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome, is a form of... more...

GeneReviews for NBK1108

Related Diseases for Autoimmune Lymphoproliferative Syndrome

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Diseases in the Lymphoproliferative Syndrome family:

Autoimmune Lymphoproliferative Syndrome, Type V Autoimmune Lymphoproliferative Syndrome, Type Iii
Lymphoproliferative Syndrome 1 autoimmune lymphoproliferative syndrome
Lymphoproliferative Syndrome 2 Autoimmune Lymphoproliferative Syndrome, Type Iib
Autoimmune Lymphoproliferative Syndrome, Type Ii Autoimmune Lymphoproliferative Syndrome Due to Ctla4 Haploinsuffiency
Casp10-Related Autoimmune Lymphoproliferative Syndrome Fas-Related Autoimmune Lymphoproliferative Syndrome
Faslg-Related Autoimmune Lymphoproliferative Syndrome Prkcd-Related Autoimmune Lymphoproliferative Syndrome
Autoimmune Lymphoproliferative Syndrome, Type 0 Autosomal Recessive Lymphoproliferative Disease

Diseases related to Autoimmune Lymphoproliferative Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis29.7CTLA4, IL10, IL2
2autoimmune lymphoproliferative syndrome, type ii12.5
3autoimmune lymphoproliferative syndrome, type iii12.4
4autoimmune lymphoproliferative syndrome, type v12.3
5autoimmune lymphoproliferative syndrome, type iib12.3
6autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency12.0
7prkcd-related autoimmune lymphoproliferative syndrome12.0
8casp10-related autoimmune lymphoproliferative syndrome11.9
9fas-related autoimmune lymphoproliferative syndrome11.9
10faslg-related autoimmune lymphoproliferative syndrome11.9
11autoimmune lymphoproliferative syndrome, type 011.9
12ras-associated autoimmune leukoproliferative disorder11.8
13eosinophilic granulomatosis with polyangiitis11.4
14churg-strauss syndrome11.2
15dianzani autoimmune lymphoproliferative disease11.2
16coffin-siris syndrome11.0
17infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations10.9
18allergic angiitis10.8
19lymphoproliferative syndrome10.8
20hereditary motor and sensory neuropathy, okinawa type10.3CASP10, FASLG, PRKCD
21pseudo-meigs syndrome10.3FAS, FASLG, IL10
22primary ciliary dyskinesia10.2CASP8, FADD, IL10
23vaginal yolk sac tumor10.2CTLA4, HRAS, NRAS
24retroperitoneal leiomyosarcoma10.2CTLA4, HRAS, NRAS
25immunoglobulin g deficiency10.2FASLG, IL10, IL2RA
26newcastle disease10.2CASP10, FAS, IL2
27chronic thromboembolic pulmonary hypertension10.2CTLA4, IL10, IL2
28non-amyloid monoclonal immunoglobulin deposition disease10.2FAS, IL2RA
29severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive10.2IL10, IL2, IL2RA
30abnormal retinal correspondence10.2CTLA4, IL10, IL2
31cyclosporiasis10.2IL10, IL2, IL2RA
32mental retardation, autosomal dominant 610.2KRAS, NRAS, PRKCD
33lymphoma10.1
34autoimmune hemolytic anemia10.1CTLA4, FASLG, IL2
35hereditary ataxia10.1FAS, IL10, IL2RA, UNC13D
36hyperaldosteronism, familial, type ii10.1FASLG, IL2, IL2RA
37malignant skin fibrous histiocytoma10.1HRAS, KRAS
38erythrocyte lactate transporter defect10.1HRAS, KRAS, NRAS
39melanocytic nevus syndrome, congenital, somatic10.1HRAS, KRAS, NRAS
40mansonelliasis10.1CTLA4, IL10, IL2
41adenylosuccinase lyase deficiency10.1FASLG, IL2, STAT3
42myiasis10.1IL10, IL2, IL2RA
43periodontosis10.1CTLA4, FASLG, IL2, IL2RA
44articulation disorder10.1CTLA4, FAS, IL10, IL2
45ossifying fibromyxoid tumor10.1HRAS, KRAS, NRAS
46heart conduction disease10.1IL10, IL2, IL2RA
47carnitine-acylcarnitine translocase deficiency10.1CASP10, FAS, IL2, PTPRC
48acute myeloid leukemia with recurrent genetic anomaly10.1FASLG, IL10, IL2, IL2RA
49spongiotic dermatitis10.1HRAS, KRAS, NRAS
50causalgia10.1IL10, IL2, IL2RA

Graphical network of the top 20 diseases related to Autoimmune Lymphoproliferative Syndrome:



Diseases related to autoimmune lymphoproliferative syndrome

Symptoms & Phenotypes for Autoimmune Lymphoproliferative Syndrome

About this section

Symptoms by clinical synopsis from OMIM:

601859

Clinical features from OMIM:

601859

Human phenotypes related to Autoimmune Lymphoproliferative Syndrome:

 64 (show all 26)
id Description HPO Frequency HPO Source Accession
1 urticaria64 HP:0001025
2 splenomegaly64 HP:0001744
3 eosinophilia64 HP:0001880
4 autoimmune hemolytic anemia64 HP:0001890
5 iron deficiency anemia64 HP:0001891
6 autoimmune neutropenia64 HP:0001904
7 autoimmune thrombocytopenia64 HP:0001973
8 hepatomegaly64 HP:0002240
9 vasculitis64 HP:0002633
10 follicular hyperplasia64 HP:0002729
11 chronic noninfectious lymphadenopathy64 HP:0002730
12 decreased lymphocyte apoptosis64 HP:0002731
13 increased number of peripheral cd3+ t cells64 HP:0002845
14 increased number of cd4-/cd8- t cells expressing alpha/beta t-cell receptors64 HP:0002851
15 increased proportion of hla dr+ and cd57+ t cells64 HP:0002853
16 rheumatoid factor positive64 HP:0002923
17 reduced delayed hypersensitivity64 HP:0002972
18 increased igg level64 HP:0003237
19 increased iga level64 HP:0003261
20 smooth muscle antibody positivity64 HP:0003262
21 antineutrophil antibody positivity64 HP:0003453
22 platelet antibody positive64 HP:0003454
23 antinuclear antibody positivity64 HP:0003493
24 increased igm level64 HP:0003496
25 antiphospholipid antibody positivity64 HP:0003613
26 coombs-positive hemolytic anemia64 HP:0004844

GenomeRNAi Phenotypes related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-17.0BCL2L11, CASP8, FADD, FAS, FASLG, IL10

MGI Mouse Phenotypes related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

41 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.4BCL2L11, CTLA4, FAS, KRAS, NRAS
2MP:00053828.5FAS, HRAS, IL10, KRAS, NRAS, SPP1
3MP:00053918.4FAS, FASLG, IL10, IL2, IL2RA, KRAS
4MP:00030128.0BCL2L11, FADD, HRAS, IL10, IL2, KRAS
5MP:00028737.8BCL2L11, CTLA4, FAS, FASLG, HRAS, IL10
6MP:00053677.6BCL2L11, CASP8, FAS, FASLG, HRAS, KRAS
7MP:00053817.5CTLA4, FADD, FAS, FASLG, IL10, IL2
8MP:00020067.1BCL2L11, CASP8, FAS, FASLG, HRAS, IL10
9MP:00053907.1CTLA4, FADD, FAS, FASLG, HRAS, IL10
10MP:00107717.1BCL2L11, CASP8, CTLA4, FAS, FASLG, HRAS
11MP:00053886.8CASP8, CTLA4, FAS, FASLG, HRAS, IL10
12MP:00053846.8BCL2L11, CASP8, FADD, FAS, FASLG, IL10
13MP:00053706.5CASP8, CTLA4, FADD, FAS, FASLG, IL10
14MP:00053796.4BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
15MP:00053856.4BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
16MP:00053786.3BCL2L11, CASP8, FADD, FAS, HRAS, IL10
17MP:00036316.2BCL2L11, CASP8, FADD, FAS, FASLG, HRAS
18MP:00107685.9BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
19MP:00053765.7BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
20MP:00053875.6BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
21MP:00053975.4BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG

Drugs & Therapeutics for Autoimmune Lymphoproliferative Syndrome

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Drugs for Autoimmune Lymphoproliferative Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 99)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cyclophosphamideapproved, investigationalPhase 4, Phase 3, Phase 2, Early Phase 1293550-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
2
Prednisoneapproved, vet_approvedPhase 4, Phase 3, Phase 2139853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3
Methylprednisoloneapproved, vet_approvedPhase 4, Phase 2119383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
4
MethotrexateapprovedPhase 4, Phase 215511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
5
AzathioprineapprovedPhase 4, Phase 3, Early Phase 1177446-86-62265
Synonyms:
446-86-6
55774-33-9 (hydrochloride salt)
6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]
6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine
6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine
6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
6-(Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(Methyl-p-nitro-5-imidazolyl)thiopurine
6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine
6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine
6-[(1-Methyl-4-nitroimidazol-5-yl)- thio] purine
6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
A 4638
A2593_SIAL
A4638_SIAL
A4638_SIGMA
AB00443544
AB00443544-03
AC-4230
AC1L1DAL
AC1Q3Z1F
AI-981/34845012
AI3-50290
Azamun
Azamun [Czech]
Azanin
Azasan
Azasan (TN)
Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine
Azathioprin
Azathioprine (JP15/USP/INN)
Azathioprine Sodium
Azathioprine [USAN:INN:BAN:JAN]
Azathioprine sodium
Azathioprinum
Azathioprinum [INN-Latin]
Azathiopurine
Azatioprin
Azatioprina
Azatioprina [INN-Spanish]
Azothioprine
B. W. 57-322
BPBio1_000054
BRD-K32821942-001-05-6
BRD-K60324116-001-01-5
BSPBio_000048
BSPBio_001876
BW 57-322
BW 57322
BW-57-322
C06837
C9H7N7O2S
CAS-446-86-6
CBDivE_013132
CCRIS 62
CHEBI:2948
CHEMBL1542
CID2265
CPD000427366
Ccucol
ChemDiv1_002659
Cytostatics
D00238
DB00993
DivK1c_000586
EINECS 207-175-4
EU-0100027
FT-0083532
HMS1568C10
HMS1920E17
 
HMS2091K19
HMS501N08
HMS594I19
HSDB 7084
IDI1_000586
Immuran
Imuran
Imuran (TN)
Imuran (tn)
Imurek
Imurel
KBio1_000586
KBio2_000464
KBio2_002427
KBio2_003032
KBio2_004995
KBio2_005600
KBio2_007563
KBio3_001376
KBio3_002906
KBioGR_000646
KBioGR_002427
KBioSS_000464
KBioSS_002433
LS-123
Lopac-A-4638
Lopac0_000027
MLS001049307
Methylnitroimidazolylmercaptopurine
MolPort-000-745-914
MolPort-000-764-262
MolPort-003-665-485
Muran
NCGC00015060-01
NCGC00015060-02
NCGC00015060-04
NCGC00015060-12
NCGC00090836-01
NCGC00090836-02
NCGC00090836-03
NCGC00090836-04
NCGC00090836-05
NCGC00090836-06
NCGC00094593-01
NCGC00094593-02
NCGC00094593-03
NCI-C03474
NINDS_000586
NSC 39084
NSC-39084
NSC39084
Oprea1_375441
Oprea1_533384
Oprea1_633462
Prestwick0_000094
Prestwick1_000094
Prestwick2_000094
Prestwick3_000094
Prestwick_41
S1721_Selleck
SAM002589938
SDCCGMLS-0065415.P001
SMR000427366
SPBio_000255
SPBio_001987
SPECTRUM1500133
STK831906
STOCK1S-20293
STOCK1S-27186
Spectrum2_000068
Spectrum3_000308
Spectrum4_000243
Spectrum5_000848
Spectrum_000064
Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl)
UNII-MRK240IY2L
WLN: T56 BM DN FN HNJ IS- ET5N CNJ A1 DNW
ZINC04258316
[Methyl(nitroimidazolyl)mercaptopurine]
azathioprine
azatiopr in
cMAP_000046
6
Prednisoloneapproved, vet_approvedPhase 4, Phase 2119350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
7
Mycophenolate mofetilapproved, investigationalPhase 4, Phase 2952128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
8
Mycophenolic acidapprovedPhase 4, Phase 295224280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
9
rituximabapprovedPhase 4, Phase 3, Phase 2, Early Phase 11692174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
10
leucovorinapproved, NutraceuticalPhase 4, Phase 2, Phase 1323558-05-954575, 6560146, 143
Synonyms:
(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolate
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
5-Formyltetrahydrofolate
5-Formyltetrahydrofolic acid
5-Formyltetrahydropteroylglutamate
5-Formyltetrahydropteroylglutamic acid
5-formyltetrahydrofolic acid
Acide folinique
Calcium citrovorum factor
Calcium folinate
Citrovorum factor
Folinate
Folinic acid
Folinic acid calcium salt
 
Folinic acid calcium salt USP27
Folinic acid-SF
L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
L-Leucovorin
L-N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-Glutamic acid
L-leucovorin
Leucal
Leucovorin calcium
Leucovorin folinic acid
Leucovorinum
Leukovorin
Levoleucovorin
N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
N5-Formyl-5,6,7,8-tetrahydrofolate
N5-Formyl-5,6,7,8-tetrahydrofolic acid
N5-Formyl-THF
N5-Formyltetrahydrofolate
N5-Formyltetrahydrofolic acid
Welcovorin
Wellcovorin
folinate
11
Folic Acidapproved, nutraceutical, vet_approvedPhase 4, Phase 2, Phase 1439259-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
12Methylprednisolone HemisuccinatePhase 4, Phase 21193
13Methylprednisolone acetatePhase 4, Phase 21193
14Alkylating AgentsPhase 4, Phase 3, Phase 24827
15Neuroprotective AgentsPhase 41716
16Prednisolone phosphatePhase 4, Phase 21193
17Vitamin B ComplexPhase 4, Phase 2, Phase 14337
18Prednisolone acetatePhase 4, Phase 21193
19Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 213168
20Nucleic Acid Synthesis InhibitorsPhase 4, Phase 24962
21Peripheral Nervous System AgentsPhase 4, Phase 323689
22Protective AgentsPhase 47443
23Prednisolone hemisuccinatePhase 4, Phase 21193
24Immunosuppressive AgentsPhase 4, Phase 3, Phase 2, Phase 113086
25AntimetabolitesPhase 4, Phase 3, Phase 212054
26Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110729
27Antirheumatic AgentsPhase 4, Phase 3, Phase 2, Phase 110956
28Antineoplastic Agents, AlkylatingPhase 4, Phase 3, Phase 24603
29HormonesPhase 4, Phase 3, Phase 214415
30Antimetabolites, AntineoplasticPhase 4, Phase 3, Phase 27361
31Antineoplastic Agents, HormonalPhase 4, Phase 3, Phase 25592
32AntiemeticsPhase 4, Phase 34022
33Gastrointestinal AgentsPhase 4, Phase 3, Phase 1, Phase 28402
34glucocorticoidsPhase 4, Phase 3, Phase 25103
35Hormone AntagonistsPhase 4, Phase 3, Phase 213180
36Autonomic AgentsPhase 4, Phase 310150
37Folic Acid AntagonistsPhase 4, Phase 2, Phase 12257
38Dermatologic AgentsPhase 4, Phase 2, Phase 15806
39Anti-Bacterial AgentsPhase 4, Phase 2, Phase 111226
40Antibiotics, AntitubercularPhase 4, Phase 2, Phase 17180
41Vitamin B9NutraceuticalPhase 4, Phase 2, Phase 14392
42FolateNutraceuticalPhase 4, Phase 2, Phase 14392
43
Dexamethasoneapproved, investigational, vet_approvedPhase 3217150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
44Dexamethasone acetatePhase 321711177-87-3
45
protease inhibitorsPhase 35471
Synonyms:
 
protease inhibitors
46HIV Protease InhibitorsPhase 35470
47Dexamethasone 21-phosphatePhase 32171
48BB 1101Phase 32171
49
Miconazoleapproved, investigational, vet_approvedPhase 1, Phase 2370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
50
Valproic Acidapproved, investigationalPhase 1, Phase 232799-66-13121
Synonyms:
(N-C3H7)2CHCOOH
(S)-2-propyl-4-pentanoate
(S)-2-propyl-4-pentanoic acid
2 PP (base)
2-N-Propyl-N-valeric acid
2-Propyl-Pentanoate
2-Propyl-Pentanoic acid
2-Propylpentanoate
2-Propylpentanoic Acid
2-Propylpentanoic acid
2-Propylvaleric Acid
2-Propylvaleric acid
2-n-Propyl-n-valeric acid
2-n-propyl-n-valeric acid
2-propyl-pentanoic acid
2-propylvaleric acid
4-Heptanecarboxylic acid
4-heptanecarboxylic acid
76584-70-8 (hydrochloride salt (2:1))
99-66-1
AC1L1F7T
AC1Q2ULA
AI3-10500
APO-divalproex
Abbott 44090
Acide valproique
Acide valproique [INN-French]
Acide valproique [inn-french]
Acido valproico
Acido valproico [INN-Spanish]
Acido valproico [inn-spanish]
Acidum valproicum
Acidum valproicum [INN-Latin]
Acidum valproicum [inn-latin]
Alti-Valproic
Alti-valproic
Apo-valproic
Apo-valproic syrup
Avugane
BIDD:GT0858
BRN 1750447
Baceca
C07185
CHEBI:39867
CHEMBL109
CID3121
CPD000499581
Convulex
Convulsofin
D00399
DB00313
DOM-divalproex
DOM-valproic
DOM-valproic acid E.C.
DPA
Delepsine
Depacon
Depakene
Depakene (TN)
Depakin
Depakin chrono
Depakine
Depakine chrono
Depakote
Depakote (TM)
Deproic
Di-N-propylacetic acid
Di-N-propylessigsaure
Di-N-propylessigsaure [german]
Di-n-propylacetic acid
Di-n-propylessigsaeure
Di-n-propylessigsaure
Di-n-propylessigsaure [German]
Di-n-propylessigsäure
Dipropyl Acetate
Dipropylacetate
Dipropylacetic acid
DivK1c_000273
Divalproex
Dom-Valproic
Dom-valproate
Dom-valproic acid
Dom-valproic acid syrup
EINECS 202-777-3
Epiject I.V.
Epilex
Epilim
Epival
Epival er
Ergenyl
G2M-777
Gen-divalproex
HMS2089J06
HSDB 3582
I04-0211
InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
KBio1_000273
KBio2_001001
KBio2_002277
KBio2_003569
KBio2_004845
 
KBio2_006137
KBio2_007413
KBio3_002626
KBio3_002757
KBioGR_000871
KBioGR_002277
KBioSS_001001
KBioSS_002278
Kyselina 2-propylvalerova
Kyselina 2-propylvalerova [Czech]
LS-161170
LS-2068
MLS001076682
MLS001335927
MLS001335928
MLS002415770
Med Valproic
Med valproic
MolPort-001-791-895
Mylproin
Myproate
Myproic Acid
Myproic acid
N-DPA
N-Dipropylacetic acid
NCGC00091149-01
NCGC00091149-02
NCGC00091149-03
NCGC00091149-04
NINDS_000273
NSC 93819
NSC93819
Novo-Valproic
Novo-Valproic - ECC
Novo-divalproex
Novo-valproic
Novo-valproic soft gel cap
Nu-Valproic
Nu-valproic
P0823
P6273_SIGMA
PEAC
PHL-valproate
PHL-valproic acid
PHL-valproic acid E.C.
PMS-Divalproex
PMS-Valproic Acid
PMS-valproate
PMS-valproic acid
PMS-valproic acid E.C.
Penta-Valproic
Penta-valproic
Propylvaleric acid
Ratio-Valproic - ECC
S(-)-4-En-valproate
S(-)-4-En-valproic acid
S-2-N-Propyl-4-pentenoate
S-2-N-Propyl-4-pentenoic acid
SAM002564230
SBB065764
SMR000499581
SPBio_000912
Sandoz valproic
Savicol
Semisodium Valproate
Sodium hydrogen divalproate
Spectrum2_000946
Spectrum3_001733
Spectrum4_000376
Spectrum_000521
Sprinkle
Stavzor
UNII-614OI1Z5WI
VALPROIC ACID
VPA
Valcote
Valparin
Valproate
Valproate semisodique [French]
Valproate semisodium
Valproato semisodico [Spanish]
Valproatum seminatricum [Latin]
Valproic Acid, Sodium Salt (2:1)
Valproic acid
Valproic acid (USP)
Valproic acid USP
Valproic acid USP24
Valproic acid [USAN:INN:BAN]
Valproic acid [usan:ban:inn]
Valproinsaeure
Valproinsäure
Vupral
WLN: QVY3 & 3
acide valproïque
acidum valproicum
di-n-propylacetic acid
n-DPA
n-Dipropylacetic acid
nchembio.79-comp4
nchembio815-comp21
valproate
valproic acid
ácido valproico

Interventional clinical trials:

(show all 50)
idNameStatusNCT IDPhase
1CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis FactorsUnknown statusNCT00399399Phase 4
2Treatment of Necrotizing Vasculitides for Patients Older Than 65 YearsCompletedNCT00307671Phase 4
3Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.Not yet recruitingNCT03164473Phase 4
4Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)CompletedNCT00647166Phase 3
5A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With PolyangiitisCompletedNCT02020889Phase 3
6Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic PurpuraCompletedNCT00657410Phase 3
7Rituximab in Eosinophilic Granulomatosis With PolyangiitisRecruitingNCT02807103Phase 3
8Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing VasculitidesUnknown statusNCT00751517Phase 2
9Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)CompletedNCT00605657Phase 1, Phase 2
10Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss SyndromeCompletedNCT00527566Phase 1, Phase 2
11Safety and Efficacy Study of Mepolizumab in Churg Strauss SyndromeCompletedNCT00716651Phase 2
12Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic SyndromeCompletedNCT00266565Phase 1, Phase 2
13Immune Disorder HSCT ProtocolRecruitingNCT01821781Phase 2
14Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCTRecruitingNCT01962415Phase 2
15Pilot Trial of Allogeneic Blood or Marrow Transplanation for Primary ImmunodeficienciesRecruitingNCT02579967Phase 2
16Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) StudyRecruitingNCT03010436Phase 2
17Sirolimus for Autoimmune Disease of Blood CellsActive, not recruitingNCT00392951Phase 1, Phase 2
18Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) StudyNot yet recruitingNCT02947945Phase 2
19Rituxan in Churg Strauss Syndrome With Renal InvolvementTerminatedNCT00424749Phase 2
20Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous DiseaseTerminatedNCT00325078Phase 1, Phase 2
21Safety Study of Anti LewisY Chimeric Antigen Receptor in Myeloma, Acute Myeloid Leukemia or Myelodysplastic SyndromeUnknown statusNCT01716364Phase 1
22Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative SyndromeCompletedNCT00013689Phase 1
23Pyrimethamine to Treat Autoimmune Lymphoproliferative SyndromeCompletedNCT00065390Phase 1
24Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive CancerCompletedNCT00060372Phase 1
25Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesUnknown statusNCT00006055
26PRO Development for ANCA Associated VasculitisUnknown statusNCT01729624
27Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) to Evaluate Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-associated LymphomaCompletedNCT00068146
28Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
29RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing VasculitidesCompletedNCT00307593
30Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
31Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
32The ANCA Vasculitis Questionnaire (AAV-PRO©)CompletedNCT02507024
33Study of Autoimmune Lymphoproliferative Syndrome (ALPS)RecruitingNCT00001350
34VCRC Tissue RepositoryRecruitingNCT02967068
35Pediatric Vasculitis InitiativeRecruitingNCT02006134
36Eosinophilic Granulomatosis With Polyangiitis CohortRecruitingNCT03036670
37Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersRecruitingNCT01758042
38American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
39One-Time DNA Study for VasculitisRecruitingNCT01241305
40Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)RecruitingNCT00315380
41Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995RecruitingNCT02116764
42Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune SystemRecruitingNCT01063309
43Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995RecruitingNCT02082353
44Vasculitis Pregnancy RegistryRecruitingNCT02593565
45Clinical Transcriptomics in Systemic Vasculitis (CUTIS)RecruitingNCT03004326
46Investigation of Immune Disorders and DeficienciesActive, not recruitingNCT01981785
47Comparative Autoantibody and Immunologic Cell Marker StudyEnrolling by invitationNCT02422875
48VCRC Patient Contact Registry Patient-Reported Data Validation StudyEnrolling by invitationNCT02190942
49Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss SyndromeNot yet recruitingNCT02728271Early Phase 1
50Fluorodeoxyglucose Imaging Studies to Detect LymphomaWithdrawnNCT01672918

Search NIH Clinical Center for Autoimmune Lymphoproliferative Syndrome


Cochrane evidence based reviews: autoimmune lymphoproliferative syndrome

Genetic Tests for Autoimmune Lymphoproliferative Syndrome

About this section

Genetic tests related to Autoimmune Lymphoproliferative Syndrome:

id Genetic test Affiliating Genes
1 Autoimmune Lymphoproliferative Syndrome27 24 FASLG
2 Autoimmune Lymphoproliferative Syndrome, Type 1b27
3 Autoimmune Lymphoproliferative Syndrome, Type 1a27
4 Autoimmune Lymphoproliferative Syndrome, Type Ia24
5 Autoimmune Lymphoproliferative Syndrome, Type Ib24

Anatomical Context for Autoimmune Lymphoproliferative Syndrome

About this section

MalaCards organs/tissues related to Autoimmune Lymphoproliferative Syndrome:

36
Spleen, Liver, Lymph node, T cells, Kidney, Eye, Skin

Publications for Autoimmune Lymphoproliferative Syndrome

About this section

Articles related to Autoimmune Lymphoproliferative Syndrome:

(show top 50)    (show all 194)
idTitleAuthorsYear
1
IgG4-related disease in autoimmune lymphoproliferative syndrome. (28478106)
2017
2
Autoimmune lymphoproliferative syndrome caused by homozygous FAS mutations with normal or residual protein expression. (28087326)
2017
3
Use of Sirolimus (Rapamycin) for Treatment of Cytopenias and Lymphoproliferation Linked to Autoimmune Lymphoproliferative Syndrome (ALPS). Two Case Reports. (28234735)
2017
4
A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. (27770190)
2017
5
TCF1 deficiency ameliorates autoimmune lymphoproliferative syndrome (ALPS)-like phenotypes of lpr/lpr mice. (28349581)
2017
6
Erratum to: A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. (28101633)
2017
7
Differential regulation of miR-146a/FAS and miR-21/FASLG axes in autoimmune lymphoproliferative syndrome due to FAS mutation (ALPS-FAS). (27060458)
2016
8
Abnormal thymic maturation and lymphoproliferation in MRL-Faslpr/lpr mice can be partially reversed by synthetic oligonucleotides: implications for systemic lupus erythematosus and autoimmune lymphoproliferative syndrome. (27837196)
2016
9
Bone marrow findings in autoimmune lymphoproliferative syndrome with germline FAS mutation. (27846610)
2016
10
Pulmonary Manifestations of the Autoimmune Lymphoproliferative Syndrome. A Retrospective Study of a Unique Patient Cohort. (27268092)
2016
11
Ocular Inflammatory Disorders in Autoimmune Lymphoproliferative Syndrome (ALPS). (27229379)
2016
12
CORRIGENDUM to Abnormal thymic maturation and lymphoproliferation in MRL-Faslpr/lpr mice can be partially reversed by synthetic oligonucleotides: implications for systemic lupus erythematosus and autoimmune lymphoproliferative syndrome. (27940897)
2016
13
Unexplained lymphadenopathies: autoimmune lymphoproliferative syndrome in an adult patient. (27979843)
2016
14
Hyperactive mTOR pathway promotes lymphoproliferation and abnormal differentiation in autoimmune lymphoproliferative syndrome. (27099149)
2016
15
Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome. (27789675)
2016
16
Optimal Management of Autoimmune Lymphoproliferative Syndrome in Children. (27139496)
2016
17
Disturbed B-lymphocyte selection in autoimmune lymphoproliferative syndrome. (26907631)
2016
18
Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome. (27845235)
2016
19
Atypical presentation of autoimmune lymphoproliferative syndrome due to CASP10 mutation. (27378136)
2016
20
Autoimmune lymphoproliferative syndrome due to somatic FAS mutation (ALPS-sFAS) combined with a germline caspase-10 (CASP10) variation. (26323380)
2016
21
Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome. (27579193)
2016
22
Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS). (25663566)
2015
23
Decreased activation-induced cell death by EBV-transformed B cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation. (26334989)
2015
24
Autoimmune lymphoproliferative syndrome-like disease in patients with LRBA mutation. (25931386)
2015
25
Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS). (26453583)
2015
26
FAS Haploinsufficiency Caused by Extracellular Missense Mutations Underlying Autoimmune Lymphoproliferative Syndrome. (26563159)
2015
27
Adult onset autoimmune lymphoproliferative syndrome due to somatic FAS mutation. (25827517)
2015
28
Approaches to Managing Autoimmune Cytopenias in Novel Immunological Disorders with Genetic Underpinnings Like Autoimmune Lymphoproliferative Syndrome. (26258116)
2015
29
Deregulation of Fas ligand expression as a novel cause of autoimmune lymphoproliferative syndrome-like disease. (26113417)
2015
30
Gray platelet syndrome can mimic autoimmune lymphoproliferative syndrome. (26472737)
2015
31
Autoimmune Lymphoproliferative Syndrome with Red Cell Aplasia. (25972287)
2015
32
Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly. (26456038)
2015
33
A novel homozygous Fas ligand mutation leads to early protein truncation, abrogation of death receptor and reverse signaling and a severe form of the autoimmune lymphoproliferative syndrome. (25451160)
2014
34
Autoimmune lymphoproliferative syndrome in pregnancy: A case of favorable mother-fetal outcome in a well-controlled disease. (25302402)
2014
35
Autoimmune lymphoproliferative syndrome: an update and review of the literature. (25086580)
2014
36
IL-10/Janus kinase/signal transducer and activator ofA transcription 3 signaling dysregulates Bim expression inA autoimmune lymphoproliferative syndrome. (25174872)
2014
37
Association of severe myoclonic epilepsy of infancy (SMEI) with probable autoimmune lymphoproliferative syndrome-variant. (25669891)
2014
38
Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. (24398331)
2014
39
Autoimmune lymphoproliferative syndrome with neonatal onset. (24906264)
2014
40
Autoimmune Lymphoproliferative Syndrome and Epstein-Barr Virus-Associated Lymphoma: An Adjunctive Diagnostic Role for Monitoring EBV Viremia? (25374737)
2013
41
Autoimmune lymphoproliferative syndrome and non-Hodgkin lymphoma: What (18)F-fluorodeoxyglucose positron emission tomography/computed tomography can do in the management of these patients? Suggestions from a case report. (23845452)
2013
42
Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome. (23840885)
2013
43
Investigation of common variable immunodeficiency patients and healthy individuals using autoimmune lymphoproliferative syndrome biomarkers. (23993982)
2013
44
Tubulointerstitial nephritis in a patient with probable autoimmune lymphoproliferative syndrome. (23588339)
2013
45
Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells. (23645835)
2013
46
Erythematous rash following romiplostim administration in a patient with autoimmune lymphoproliferative syndrome. (23300150)
2013
47
Diagnosis of autoimmune lymphoproliferative syndrome caused by FAS deficiency in adults. (22983577)
2013
48
Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation. (22857792)
2013
49
Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis. (24101757)
2013
50
Somatic loss of heterozygosity, but not haploinsufficiency alone, leads to full-blown autoimmune lymphoproliferative syndrome in 1 of 12 family members with FAS start codon mutation. (23524443)
2013

Variations for Autoimmune Lymphoproliferative Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Autoimmune Lymphoproliferative Syndrome:

70 (show all 23)
id Symbol AA change Variation ID SNP ID
1FASLGp.Cys202SerVAR_075568
2FASp.Thr28AlaVAR_013417
3FASp.Cys82ArgVAR_013418
4FASp.Arg121TrpVAR_013419rs121913078
5FASp.Tyr232CysVAR_013423rs121913079
6FASp.Thr241LysVAR_013424rs201072885
7FASp.Thr241ProVAR_013425rs121913076
8FASp.Arg250ProVAR_013426rs121913080
9FASp.Arg250GlnVAR_013427
10FASp.Ala257AspVAR_013428
11FASp.Asp260GlyVAR_013429
12FASp.Asp260TyrVAR_013430rs121913086
13FASp.Asp260ValVAR_013431rs28929498
14FASp.Thr270IleVAR_013433rs121913081
15FASp.Glu272GlyVAR_013434
16FASp.Glu272LysVAR_013435
17FASp.Ile310SerVAR_013438
18FASp.Ile262SerVAR_058910
19FASp.Val249LeuVAR_065128
20FASp.Gly253AspVAR_065129
21FASp.Gly253SerVAR_065130
22FASp.Ile259ArgVAR_065131
23FASp.Thr270LysVAR_065132

Clinvar genetic disease variations for Autoimmune Lymphoproliferative Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FASLGNM_ 000639.2(FASLG): c.263delT (p.Phe88Serfs)deletionPathogenicrs587776450GRCh37Chr 1, 172628604: 172628604
2FASLGNM_ 000639.2(FASLG): c.466A> G (p.Arg156Gly)SNVPathogenicrs80358238GRCh37Chr 1, 172634776: 172634776

Expression for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Search GEO for disease gene expression data for Autoimmune Lymphoproliferative Syndrome.

Pathways for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Pathways related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idSuper pathwaysScoreTop Affiliating Genes
110.0CASP8, FADD
29.9FAS, FASLG, IL10
39.8CASP10, CASP8, FADD
49.8CASP8, FADD, PRKCD
59.8FAS, FASLG, HRAS
6
Show member pathways
9.7BCL2L11, CASP8, FAS
7
Show member pathways
9.7CASP10, CASP8, FAS, FASLG
89.7CTLA4, IL10, IL2RA
99.7CASP8, FADD, FAS, FASLG
109.7CASP10, CASP8, FADD, FAS
119.7IL10, IL2, PTPRC
12
Show member pathways
9.6FASLG, IL2, IL2RA
13
Show member pathways
9.6FASLG, IL2, IL2RA
149.6CASP10, CASP8, FADD, IL10
159.6CASP8, PRKCD, STAT3
169.6IL10, IL2, IL2RA
179.6IL10, PTPRC, STAT3
189.5HRAS, PRKCD, STAT3
19
Show member pathways
9.5HRAS, IL2, IL2RA
20
Show member pathways
9.5CASP10, CASP8, FADD, FAS, FASLG
21
Show member pathways
9.5CASP10, CASP8, FADD, FAS, FASLG
22
Show member pathways
9.5CASP8, FADD, IL2, PRKCD
23
Show member pathways
9.4HRAS, KRAS, NRAS
24
Show member pathways
9.4HRAS, KRAS, NRAS
259.4HRAS, KRAS, NRAS
269.4HRAS, KRAS, NRAS
279.4HRAS, KRAS, NRAS
289.4HRAS, KRAS, NRAS
299.4HRAS, KRAS, NRAS
309.4HRAS, KRAS, NRAS
319.4HRAS, KRAS, NRAS
329.4HRAS, KRAS, NRAS
339.4HRAS, KRAS, NRAS
34
Show member pathways
9.4HRAS, KRAS, NRAS
359.4HRAS, KRAS, NRAS
369.4HRAS, KRAS, NRAS
379.4HRAS, KRAS, NRAS
389.4HRAS, KRAS, NRAS
39
Show member pathways
9.4HRAS, KRAS, NRAS
409.4BCL2L11, KRAS, PRKCD
419.4BCL2L11, FAS, FASLG, IL2
42
Show member pathways
9.4CTLA4, FASLG, IL2, IL2RA
439.4IL10, IL2, IL2RA, PTPRC
449.4IL10, IL2, IL2RA, PTPRC
459.4IL2, IL2RA, STAT3
46
Show member pathways
9.3BCL2L11, CASP8, FADD, FAS, FASLG
479.3BCL2L11, CASP8, FADD, FAS, FASLG
489.2HRAS, KRAS, NRAS, PRKCD
49
Show member pathways
9.2HRAS, KRAS, NRAS, PRKCD
509.2HRAS, KRAS, NRAS, PRKCD

GO Terms for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Cellular components related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:003126410.5CASP8, FADD, FAS
2CD95 death-inducing signaling complexGO:003126510.3CASP10, CASP8, FADD, FAS
3external side of plasma membraneGO:000989710.0CTLA4, FAS, FASLG, IL2RA, PTPRC
4ripoptosomeGO:00973429.8CASP10, CASP8, FADD
5membrane raftGO:00451219.1CASP8, FADD, FAS, FASLG, KRAS, PTPRC

Biological processes related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.9FAS, FASLG
2activation of cysteine-type endopeptidase activityGO:009720210.8CASP8, FADD
3motor neuron apoptotic processGO:009704910.8FADD, FAS
4death-inducing signaling complex assemblyGO:007155010.8CASP8, FADD
5activation-induced cell death of T cellsGO:000692410.8FAS, IL2RA
6regulation of necroptotic processGO:006054410.7CASP8, FADD
7execution phase of apoptosisGO:009719410.7CASP10, CASP8, PRKCD
8extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.7FADD, FAS, FASLG
9positive regulation of protein homooligomerizationGO:003246410.7BCL2L11, FAS
10necroptotic signaling pathwayGO:009752710.6FADD, FAS, FASLG
11cellular response to mechanical stimulusGO:007126010.6CASP8, FADD, FAS
12B cell proliferationGO:004210010.6IL10, PRKCD, PTPRC
13negative regulation of lymphocyte proliferationGO:005067210.6IL2, IL2RA
14negative regulation of T cell proliferationGO:004213010.5CTLA4, IL10, IL2RA
15activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.5CASP8, FADD, FAS, FASLG
16activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.5CASP8, FADD, FAS, FASLG
17regulation of T cell homeostatic proliferationGO:004601310.5IL2, IL2RA
18extrinsic apoptotic signaling pathwayGO:009719110.5CASP8, FADD, FAS, FASLG
19negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.4CASP8, FADD, FAS, FASLG
20positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.4CASP10, CASP8, FADD, FASLG
21regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.3CASP8, FADD, FAS, FASLG
22positive regulation of activated T cell proliferationGO:004210410.3FADD, IL2, IL2RA
23response to isolation stressGO:003590010.3HRAS, KRAS
24response to lipopolysaccharideGO:003249610.3CASP8, FAS, FASLG, IL10
25apoptotic signaling pathwayGO:009719010.3CASP10, CASP8, FADD, FAS, FASLG
26positive regulation of T cell proliferationGO:004210210.3IL2, IL2RA, PTPRC
27spleen developmentGO:004853610.3BCL2L11, FADD, FAS
28positive regulation of interferon-gamma productionGO:003272910.3FADD, HRAS, IL2
29epidermal growth factor receptor signaling pathwayGO:000717310.2HRAS, KRAS, NRAS
30ERBB2 signaling pathwayGO:003812810.2HRAS, KRAS, NRAS
31response to glucocorticoidGO:005138410.2FAS, IL10, KRAS
32negative regulation of inflammatory responseGO:005072810.2IL10, IL2, IL2RA, PRKCD
33Ras protein signal transductionGO:000726510.1HRAS, KRAS, NRAS
34extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.1BCL2L11, FADD, FAS, IL2
35TRAIL-activated apoptotic signaling pathwayGO:003646210.0CASP8, FADD
36positive regulation of apoptotic processGO:004306510.0BCL2L11, CTLA4, FADD, FAS, FASLG
37regulation of apoptotic processGO:004298110.0BCL2L11, CASP10, CASP8, FADD, FAS
38neutrophil degranulationGO:00433129.9NRAS, PRKCD, PTPRC, TCN1, UNC13D
39cell surface receptor signaling pathwayGO:00071669.8CASP10, CASP8, FADD, HRAS, IL2RA, PTPRC
40positive regulation of protein phosphorylationGO:00019349.8FAS, HRAS, IL2, KRAS
41immune responseGO:00069559.8CTLA4, FAS, FASLG, IL10, IL2, IL2RA
42stimulatory C-type lectin receptor signaling pathwayGO:00022239.7HRAS, KRAS, NRAS, PRKCD
43MAPK cascadeGO:00001659.5HRAS, IL2, IL2RA, KRAS, NRAS
44inflammatory responseGO:00069549.5FAS, IL10, IL2RA, SPP1, STAT3
45T cell homeostasisGO:00430299.4BCL2L11, FADD, FAS, IL2RA
46positive regulation of cell proliferationGO:00082849.4FASLG, HRAS, IL2, KRAS, STAT3
47apoptotic processGO:00069159.2BCL2L11, CASP10, CASP8, FADD, FAS, FASLG

Molecular functions related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009719910.7CASP10, CASP8
2cysteine-type endopeptidase activity involved in execution phase of apoptosisGO:009720010.7CASP10, CASP8
3death receptor bindingGO:000512310.5CASP8, FADD, FASLG
4death effector domain bindingGO:003587710.5CASP10, CASP8, FADD
5tumor necrosis factor receptor bindingGO:00051649.9CASP8, FADD, FASLG
6cytokine activityGO:00051259.7FASLG, IL10, IL2, SPP1
7protein complex bindingGO:00324039.7CASP8, FADD, KRAS, NRAS

Sources for Autoimmune Lymphoproliferative Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet