MCID: ATM006
MIFTS: 71

Autoimmune Lymphoproliferative Syndrome malady

Categories: Genetic diseases, Rare diseases, Blood diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Autoimmune Lymphoproliferative Syndrome

About this section
Sources:
11Disease Ontology, 12diseasecard, 13DISEASES, 23GeneReviews, 24GeneTests, 25Genetics Home Reference, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 36MedGen, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
See all MalaCards sources

Aliases & Descriptions for Autoimmune Lymphoproliferative Syndrome:

Name: Autoimmune Lymphoproliferative Syndrome 51 11 23 47 24 25 53 26 49 38 13 67
Canale-Smith Syndrome 11 23 47 24 25 53 69
Alps 11 23 47 24 25 53
Autoimmune Lymphoproliferative Syndrome, Type Ia 51 24 12 67
Autoimmune Lymphoproliferative Syndrome, Type Ib 51 24 67
Autoimmune Lymphoproliferative Syndrome Type Ia 69 26
Autoimmune Lymphoproliferative Syndrome Type Ib 69 26
Fas Deficiency 47 53
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant 47
Autoimmune Lymphoproliferative Syndrome 1b 69
 
Autoimmune Lymphoproliferative Syndrome 1a 69
Coffin-Siris Syndrome 67
Alps Ia 24
Alps Ib 24
Alps 1a 24
Alps 1b 24
Alps1a 69
Alps1b 69
Css 69

Characteristics:

Orphanet epidemiological data:

53
autoimmune lymphoproliferative syndrome:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: All ages

HPO:

63
autoimmune lymphoproliferative syndrome:
Inheritance: autosomal dominant inheritance

GeneReviews:

23
Penetrance: alps-fas. a distinction needs to be made between the penetrance of the cellular phenotype (defective fas-mediated apoptosis) and the penetrance of the clinical phenotype (i.e., alps)...


Classifications:



External Ids:

OMIM51 601859
Disease Ontology11 DOID:6688
ICD1029 D47.9, D89.82
ICD9CM31 279.41
MeSH38 D056735
NCIt44 C37864
SNOMED-CT61 702444009
Orphanet53 ORPHA3261
MESH via Orphanet39 D056735
UMLS via Orphanet68 C1328840
ICD10 via Orphanet30 D47.9

Summaries for Autoimmune Lymphoproliferative Syndrome

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NIH Rare Diseases:47 Autoimmune lymphoproliferative syndrome (ALPS) is a disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). This results in the overproduction of lymphocytes, which build up and cause enlargement of the lymph nodes, liver and spleen. Affected individuals have an increased risk of developing cancer of the immune system cells (lymphoma) and may be at increased risk for other cancers. They can also have a variety of autoimmune disorders, most of which damage the blood cells. Some of the autoimmune disorders associated with ALPS can also damage the kidneys, liver, eyes, nerves, or connective tissues. Other signs and symptoms may include skin rashes, panniculitis, arthritis, inflammation of blood vessels (vasculitis), mouth sores, premature ovarian failure, and the development of neurological damage. ALPS is caused by mutations in the FAS gene in about 75% of cases. It is usually inherited in an autosomal dominant manner, although a small number of cases are inherited in an autosomal recessive manner. Some cases are also believed to arise from a mutation in the lymphocytes that is not inherited, but instead occurs during the course of an individual's lifetime. This type of alteration is called a somatic mutation. Treatment may include steroids or other medications, blood transfusions, and/or splenectomy depending on the severity of the disorder. Last updated: 8/16/2016

MalaCards based summary: Autoimmune Lymphoproliferative Syndrome, also known as canale-smith syndrome, is related to systemic lupus erythematosus and autoimmune lymphoproliferative syndrome, type ii, and has symptoms including urticaria, splenomegaly and eosinophilia. An important gene associated with Autoimmune Lymphoproliferative Syndrome is FASLG (Fas Ligand), and among its related pathways are African trypanosomiasis and TNF signaling pathway. Affiliated tissues include lymph node, spleen and liver, and related mouse phenotypes are no phenotypic analysis and renal/urinary system.

Disease Ontology:11 A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

Genetics Home Reference:25 Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). ALPS is characterized by the production of an abnormally large number of lymphocytes (lymphoproliferation). Accumulation of excess lymphocytes results in enlargement of the lymph nodes (lymphadenopathy), the liver (hepatomegaly), and the spleen (splenomegaly).

OMIM:51 Autoimmune lymphoproliferative syndrome is a heritable disorder of apoptosis, resulting in the accumulation of... (601859) more...

UniProtKB/Swiss-Prot:69 Autoimmune lymphoproliferative syndrome 1A: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Wikipedia:70 Autoimmune lymphoproliferative syndrome (ALPS), also known as Canale-Smith syndrome, is a form of... more...

GeneReviews for NBK1108

Related Diseases for Autoimmune Lymphoproliferative Syndrome

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Diseases in the Lymphoproliferative Syndrome family:

Autoimmune Lymphoproliferative Syndrome, Type V Autoimmune Lymphoproliferative Syndrome, Type Iii
Lymphoproliferative Syndrome 1 autoimmune lymphoproliferative syndrome
Lymphoproliferative Syndrome 2 Autoimmune Lymphoproliferative Syndrome, Type Iib
Autoimmune Lymphoproliferative Syndrome, Type Ii Autoimmune Lymphoproliferative Syndrome Due to Ctla4 Haploinsuffiency
Casp10-Related Autoimmune Lymphoproliferative Syndrome Fas-Related Autoimmune Lymphoproliferative Syndrome
Faslg-Related Autoimmune Lymphoproliferative Syndrome Prkcd-Related Autoimmune Lymphoproliferative Syndrome
Autoimmune Lymphoproliferative Syndrome, Type 0 Autosomal Recessive Lymphoproliferative Disease

Diseases related to Autoimmune Lymphoproliferative Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus28.8CTLA4, FAS, FASLG, IL10, IL2, IL2RA
2autoimmune lymphoproliferative syndrome, type ii12.5
3autoimmune lymphoproliferative syndrome, type iii12.4
4autoimmune lymphoproliferative syndrome, type v12.3
5autoimmune lymphoproliferative syndrome, type iib12.3
6autoimmune lymphoproliferative syndrome due to ctla4 haploinsuffiency12.0
7prkcd-related autoimmune lymphoproliferative syndrome12.0
8casp10-related autoimmune lymphoproliferative syndrome11.9
9fas-related autoimmune lymphoproliferative syndrome11.9
10faslg-related autoimmune lymphoproliferative syndrome11.9
11autoimmune lymphoproliferative syndrome, type 011.9
12ras-associated autoimmune leukoproliferative disorder11.8
13eosinophilic granulomatosis with polyangiitis11.4
14churg-strauss syndrome11.2
15dianzani autoimmune lymphoproliferative disease11.1
16coffin-siris syndrome11.0
17infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations10.9
18allergic angiitis10.8
19lymphoproliferative syndrome10.8
20pediatric systemic lupus erythematosus10.5FAS, FASLG
2112p12.1 microdeletion syndrome10.5FAS, FASLG, IL10
22granulomatous gastritis10.5FAS, FASLG
23asbestosis10.5CASP8, FAS, FASLG
24hashimoto thyroiditis10.5CTLA4, FAS, FASLG
25eye accommodation disease10.4IL10, IL2RA
26primary biliary cirrhosis10.4CASP8, FADD, IL10
27melanocytic nevus syndrome, congenital, somatic10.3HRAS, NRAS
28benign adult familial myoclonic epilepsy10.3FAS, IL10, IL2RA
29retroperitoneal fibrosis10.3FASLG, IL10, IL2RA
30demyelinating polyneuropathy10.3HRAS, NRAS
31esophagus leiomyosarcoma10.2CTLA4, HRAS, NRAS
32childhood choriocarcinoma of the testis10.2CTLA4, FAS, FASLG, IL2RA
33sublingual gland adenoid cystic carcinoma10.2HRAS, NRAS
34lacrimal system cancer10.2CASP10, FAS, IL2
35epidermal nevus, somatic10.1HRAS, NRAS
36lymphoma10.1
37laryngeal cancer, childhood10.1IL2RA, STAT3
38eczematous dermatitis of eyelid10.1FAS, FASLG, IL2
39cerebellar disease10.1FASLG, HRAS, IL10
40neurotic disorder10.1HRAS, NRAS, PTPRC
41schimmelpenning-feuerstein-mims syndrome, somatic mosaic10.1HRAS, NRAS
42calcifying epithelial odontogenic tumor10.1CTLA4, IL10, IL2
43papillary serous adenocarcinoma10.1CASP8, IL2, NRAS
44gastric ulcer10.1CTLA4, IL10, IL2
45coloboma of macula and skeletal anomalies10.1HRAS, NRAS
46chronic inflammatory demyelinating polyradiculoneuropathy10.1HRAS, NRAS
47kernicterus10.0FAS, IL10, IL2
48hereditary conventional renal cell carcinoma10.0CTLA4, IL10, IL2
49blood group incompatibility10.0CTLA4, IL10, IL2
50myelofibrosis10.0CTLA4, IL10, IL2

Graphical network of the top 20 diseases related to Autoimmune Lymphoproliferative Syndrome:



Diseases related to autoimmune lymphoproliferative syndrome

Symptoms for Autoimmune Lymphoproliferative Syndrome

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Symptoms by clinical synopsis from OMIM:

601859

Clinical features from OMIM:

601859

Human phenotypes related to Autoimmune Lymphoproliferative Syndrome:

 63 (show all 26)
id Description HPO Frequency HPO Source Accession
1 urticaria63 HP:0001025
2 splenomegaly63 HP:0001744
3 eosinophilia63 HP:0001880
4 autoimmune hemolytic anemia63 HP:0001890
5 iron deficiency anemia63 HP:0001891
6 autoimmune neutropenia63 HP:0001904
7 autoimmune thrombocytopenia63 HP:0001973
8 hepatomegaly63 HP:0002240
9 vasculitis63 HP:0002633
10 follicular hyperplasia63 HP:0002729
11 chronic noninfectious lymphadenopathy63 HP:0002730
12 decreased lymphocyte apoptosis63 HP:0002731
13 increased number of peripheral cd3+ t cells63 HP:0002845
14 increased number of cd4-/cd8- t cells expressing alpha/beta t-cell receptors63 HP:0002851
15 increased proportion of hla dr+ and cd57+ t cells63 HP:0002853
16 rheumatoid factor positive63 HP:0002923
17 reduced delayed hypersensitivity63 HP:0002972
18 increased igg level63 HP:0003237
19 increased iga level63 HP:0003261
20 smooth muscle antibody positivity63 HP:0003262
21 antineutrophil antibody positivity63 HP:0003453
22 platelet antibody positive63 HP:0003454
23 antinuclear antibody positivity63 HP:0003493
24 increased igm level63 HP:0003496
25 antiphospholipid antibody positivity63 HP:0003613
26 coombs-positive hemolytic anemia63 HP:0004844

UMLS symptoms related to Autoimmune Lymphoproliferative Syndrome:


seizures, joint laxity, hepatomegaly, pain of lymph node

Drugs & Therapeutics for Autoimmune Lymphoproliferative Syndrome

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Drugs for Autoimmune Lymphoproliferative Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 99)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cyclophosphamideapproved, investigationalPhase 4, Phase 3, Phase 2, Early Phase 1282950-18-0, 6055-19-22907
Synonyms:
(+-)-Cyclophosphamide
(-)-Cyclophosphamide
(RS)-Cyclophosphamide
1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine
1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin
2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide
4-Hydroxy-cyclophosphan-mamophosphatide
50-18-0
60007-95-6
6055-19-2 (monohydrate)
75526-90-8
AC1L1EQQ
AI3-26198
ASTA
ASTA B518
Anhydrous cyclophosphamide
Asta B 518
B 518
B-518
BRN 0011744
BSPBio_002099
Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester
C 0768
C07888
C7H15Cl2N2O2P
CB 4564
CB-4564
CCRIS 188
CHEBI:4027
CHEMBL32520
CHEMBL88
CID2907
CP
CPA
CTX
CY
Ciclofosfamida
Ciclofosfamida [INN-Spanish]
Ciclofosfamide
Ciclophosphamide
Ciclophosphamide [INN]
Clafen
Claphene
Cycloblastin
Cyclophosphamid
Cyclophosphamide
Cyclophosphamide (INN)
Cyclophosphamide (TN)
Cyclophosphamide (anhydrous form)
Cyclophosphamide (anhydrous)
Cyclophosphamide Monohydrate
Cyclophosphamide Sterile
Cyclophosphamide anhydrous
Cyclophosphamide, (+-)-Isomer
Cyclophosphamides
Cyclophosphamidum
Cyclophosphamidum [INN-Latin]
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclophosphoramide
Cyclostin
Cyklofosfamid
Cyklofosfamid [Czech]
Cytophosphan
Cytophosphane
Cytoxan
Cytoxan (TN)
Cytoxan Lyoph
D,L-Cyclophosphamide
D07760
 
DB00531
DivK1c_000246
EINECS 200-015-4
EU-0100238
Endoxan
Endoxan R
Endoxan-Asta
Endoxana
Endoxanal
Endoxane
Enduxan
Genoxal
HMS2090A12
HSDB 3047
Hexadrin
IDI1_000246
KBio1_000246
KBio2_001338
KBio2_003906
KBio2_006474
KBio3_001319
KBioGR_000888
KBioSS_001338
LS-1302
LS-99787
Ledoxina
Lopac-C-0768
Lopac0_000238
Lyophilized Cytoxan
Mitoxan
MolPort-001-783-420
N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
NCGC00015209-01
NCGC00015209-03
NCGC00015209-06
NCGC00091741-02
NCGC00091741-03
NCI-C04900
NCI60_002097
NINDS_000246
NSC 26271
NSC-26271
NSC26271
NSC273033
NSC273034
Neosar
Occupation, cyclophosphamide exposure
Procytox
RCRA waste no. U058
Rcra Waste Number U058
Rcra waste number U058
Revimmune
S1217_Selleck
SK 20501
SPBio_001071
STK177249
STOCK2S-91217
Semdoxan
Sendoxan
Senduxan
Spectrum2_001146
Spectrum3_000370
Spectrum4_000304
Spectrum5_000795
Spectrum_000858
UNII-6UXW23996M
WLN: T6MPOTJ BO BN2G2G
Zyklophosphamid
Zyklophosphamid [German]
bis(2-Chloroethyl)phosphami de cyclic propanolamide
bis(2-Chloroethyl)phosphamide cyclic propanolamide ester
cyclophosphamide
2
Prednisoloneapproved, vet_approvedPhase 4, Phase 2115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3
Prednisoneapproved, vet_approvedPhase 4, Phase 3, Phase 2135953-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
4
AzathioprineapprovedPhase 4, Phase 3, Early Phase 1165446-86-62265
Synonyms:
446-86-6
55774-33-9 (hydrochloride salt)
6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]
6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine
6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine
6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
6-(Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(Methyl-p-nitro-5-imidazolyl)thiopurine
6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine
6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine
6-[(1-Methyl-4-nitroimidazol-5-yl)- thio] purine
6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
A 4638
A2593_SIAL
A4638_SIAL
A4638_SIGMA
AB00443544
AB00443544-03
AC-4230
AC1L1DAL
AC1Q3Z1F
AI-981/34845012
AI3-50290
Azamun
Azamun [Czech]
Azanin
Azasan
Azasan (TN)
Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine
Azathioprin
Azathioprine (JP15/USP/INN)
Azathioprine Sodium
Azathioprine [USAN:INN:BAN:JAN]
Azathioprine sodium
Azathioprinum
Azathioprinum [INN-Latin]
Azathiopurine
Azatioprin
Azatioprina
Azatioprina [INN-Spanish]
Azothioprine
B. W. 57-322
BPBio1_000054
BRD-K32821942-001-05-6
BRD-K60324116-001-01-5
BSPBio_000048
BSPBio_001876
BW 57-322
BW 57322
BW-57-322
C06837
C9H7N7O2S
CAS-446-86-6
CBDivE_013132
CCRIS 62
CHEBI:2948
CHEMBL1542
CID2265
CPD000427366
Ccucol
ChemDiv1_002659
Cytostatics
D00238
DB00993
DivK1c_000586
EINECS 207-175-4
EU-0100027
FT-0083532
HMS1568C10
HMS1920E17
 
HMS2091K19
HMS501N08
HMS594I19
HSDB 7084
IDI1_000586
Immuran
Imuran
Imuran (TN)
Imuran (tn)
Imurek
Imurel
KBio1_000586
KBio2_000464
KBio2_002427
KBio2_003032
KBio2_004995
KBio2_005600
KBio2_007563
KBio3_001376
KBio3_002906
KBioGR_000646
KBioGR_002427
KBioSS_000464
KBioSS_002433
LS-123
Lopac-A-4638
Lopac0_000027
MLS001049307
Methylnitroimidazolylmercaptopurine
MolPort-000-745-914
MolPort-000-764-262
MolPort-003-665-485
Muran
NCGC00015060-01
NCGC00015060-02
NCGC00015060-04
NCGC00015060-12
NCGC00090836-01
NCGC00090836-02
NCGC00090836-03
NCGC00090836-04
NCGC00090836-05
NCGC00090836-06
NCGC00094593-01
NCGC00094593-02
NCGC00094593-03
NCI-C03474
NINDS_000586
NSC 39084
NSC-39084
NSC39084
Oprea1_375441
Oprea1_533384
Oprea1_633462
Prestwick0_000094
Prestwick1_000094
Prestwick2_000094
Prestwick3_000094
Prestwick_41
S1721_Selleck
SAM002589938
SDCCGMLS-0065415.P001
SMR000427366
SPBio_000255
SPBio_001987
SPECTRUM1500133
STK831906
STOCK1S-20293
STOCK1S-27186
Spectrum2_000068
Spectrum3_000308
Spectrum4_000243
Spectrum5_000848
Spectrum_000064
Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl)
UNII-MRK240IY2L
WLN: T56 BM DN FN HNJ IS- ET5N CNJ A1 DNW
ZINC04258316
[Methyl(nitroimidazolyl)mercaptopurine]
azathioprine
azatiopr in
cMAP_000046
5
Methylprednisoloneapproved, vet_approvedPhase 4, Phase 2115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
6
MethotrexateapprovedPhase 4, Phase 215181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
7
Mycophenolate mofetilapproved, investigationalPhase 4, Phase 2939128794-94-55281078
Synonyms:
115007-34-6
128794-94-5
140401-05-4
2-Morpholinoethyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-Morpholinoethyl (e)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoate
2-morpholin-4-ylethyl (4E)-6-[4-hydroxy-7-methyl-6-(methyloxy)-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoate
2-morpholin-4-ylethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methylhex-4-enoate
4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl -3-oxo-5-isobenzofuranyl)-4-methyl-, 2-(4-morpholinyl)ethyl ester, (4E)
AC-1562
AC1NQXZW
AC1Q6O6X
AR-1J6939
BB_NC-2566
C07908
C23H31NO7
CHEMBL1456
CID5281078
CellCept
CellCept, RS 61443, TM-MMF, Mycophenolate mofetil
Cellcept
Cellcept (TN)
D00752
DB00688
HMS2090A03
 
HSDB 7436
I01-0898
I06-1947
LS-172272
LS-75572
ME-MPA
MMF
MMF CellCept(TM)
MolPort-000-883-800
Munoloc
Mycophenolate mofetil (JAN/USAN)
Mycophenolic acid morpholinoethyl ester
Mycophenylate mofetil
NCGC00159459-02
NCGC00159459-03
NSC724229
R-99
RS 61443
RS-61443
RS-61443-190
S1501_Selleck
TL8000648
TM-MMF
UNII-9242ECW6R0
ZINC21297660
mycophenolate mofetil
8
Mycophenolic acidapprovedPhase 4, Phase 293924280-93-1446541
Synonyms:
(e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
Acide mycophenolique
Acido micofenolico
Acidum mycophenolicum
 
Melbex
Micofenolico acido
Mycophenoic acid
Mycophenolate
Mycophenolsäure
Myfortic
9
Folic Acidapproved, nutraceutical, vet_approvedPhase 4, Phase 2, Phase 1427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
10Methylprednisolone HemisuccinatePhase 4, Phase 21153
11Methylprednisolone acetatePhase 4, Phase 21153
12Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 3, Phase 212767
13Peripheral Nervous System AgentsPhase 4, Phase 322776
14Protective AgentsPhase 47190
15Vitamin B ComplexPhase 4, Phase 2, Phase 14229
16Alkylating AgentsPhase 4, Phase 3, Phase 24694
17Prednisolone phosphatePhase 4, Phase 21153
18Prednisolone hemisuccinatePhase 4, Phase 21153
19Nucleic Acid Synthesis InhibitorsPhase 4, Phase 24855
20HormonesPhase 4, Phase 3, Phase 213979
21Neuroprotective AgentsPhase 41672
22Prednisolone acetatePhase 4, Phase 21153
23Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 2, Phase 110355
24Antineoplastic Agents, HormonalPhase 4, Phase 3, Phase 25407
25AntiemeticsPhase 4, Phase 33888
26Hormone AntagonistsPhase 4, Phase 3, Phase 212778
27Antirheumatic AgentsPhase 4, Phase 3, Phase 2, Phase 110627
28AntimetabolitesPhase 4, Phase 3, Phase 211774
29Autonomic AgentsPhase 4, Phase 39774
30Dermatologic AgentsPhase 4, Phase 2, Phase 15674
31Gastrointestinal AgentsPhase 4, Phase 3, Phase 1, Phase 28109
32glucocorticoidsPhase 4, Phase 3, Phase 24920
33Antimetabolites, AntineoplasticPhase 4, Phase 3, Phase 27171
34Folic Acid AntagonistsPhase 4, Phase 2, Phase 12200
35Antineoplastic Agents, AlkylatingPhase 4, Phase 3, Phase 24474
36Immunosuppressive AgentsPhase 4, Phase 3, Phase 2, Phase 112770
37Antibiotics, AntitubercularPhase 4, Phase 2, Phase 16972
38Anti-Bacterial AgentsPhase 4, Phase 2, Phase 110884
39Folinic AcidNutraceuticalPhase 4, Phase 2, Phase 13150
40Vitamin B9NutraceuticalPhase 4, Phase 2, Phase 14279
41FolateNutraceuticalPhase 4, Phase 2, Phase 14279
42
rituximabapprovedPhase 3, Phase 2, Early Phase 11654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
43
Dexamethasoneapproved, investigational, vet_approvedPhase 3208450-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
44HIV Protease InhibitorsPhase 35319
45
protease inhibitorsPhase 35320
Synonyms:
 
protease inhibitors
46Dexamethasone acetatePhase 320841177-87-3
47Dexamethasone 21-phosphatePhase 32084
48BB 1101Phase 32084
49
Miconazoleapproved, investigational, vet_approvedPhase 1, Phase 2362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
50
InfliximabapprovedPhase 1, Phase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade

Interventional clinical trials:

(show all 48)
idNameStatusNCT IDPhase
1CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis FactorsUnknown statusNCT00399399Phase 4
2Treatment of Necrotizing Vasculitides for Patients Older Than 65 YearsCompletedNCT00307671Phase 4
3Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome)CompletedNCT00647166Phase 3
4A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With PolyangiitisCompletedNCT02020889Phase 3
5Rituximab in Eosinophilic Granulomatosis With PolyangiitisRecruitingNCT02807103Phase 3
6Prednisone or Dexamethasone in Newly Diagnosed, Previously Untreated Primary Immune Thrombocytopenic PurpuraActive, not recruitingNCT00657410Phase 3
7Mepolizumab As a Steroid-Sparing Treatment Option in the Churg Strauss SyndromeUnknown statusNCT00527566Phase 1, Phase 2
8Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing VasculitidesUnknown statusNCT00751517Phase 2
9Valproic Acid (Depakote[Registered Trademark]) to Treat Autoimmune Lymphoproliferative Syndrome (ALPS)CompletedNCT00605657Phase 1, Phase 2
10Safety and Efficacy Study of Mepolizumab in Churg Strauss SyndromeCompletedNCT00716651Phase 2
11Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic SyndromeCompletedNCT00266565Phase 1, Phase 2
12Immune Disorder HSCT ProtocolRecruitingNCT01821781Phase 2
13Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCTRecruitingNCT01962415Phase 2
14Pilot Trial of Allogeneic Blood or Marrow Transplanation for Primary ImmunodeficienciesRecruitingNCT02579967Phase 2
15Sirolimus for Autoimmune Disease of Blood CellsActive, not recruitingNCT00392951Phase 1, Phase 2
16Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) StudyNot yet recruitingNCT03010436Phase 2
17Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) StudyNot yet recruitingNCT02947945Phase 2
18Rituxan in Churg Strauss Syndrome With Renal InvolvementTerminatedNCT00424749Phase 2
19Infliximab to Treat Crohn'S-like Inflammatory Bowel Disease in Chronic Granulomatous DiseaseTerminatedNCT00325078Phase 1, Phase 2
20Safety Study of Anti LewisY Chimeric Antigen Receptor in Myeloma, Acute Myeloid Leukemia or Myelodysplastic SyndromeUnknown statusNCT01716364Phase 1
21Pyrimethamine and Sulfadoxine for Treatment of Autoimmune Lymphoproliferative SyndromeCompletedNCT00013689Phase 1
22Pyrimethamine to Treat Autoimmune Lymphoproliferative SyndromeCompletedNCT00065390Phase 1
23Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive CancerCompletedNCT00060372Phase 1
24Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune DiseasesUnknown statusNCT00006055
25Fluorodeoxyglucose-Positron Emission Tomography (FDG-PET) to Evaluate Autoimmune Lymphoproliferative Syndrome (ALPS) and ALPS-associated LymphomaCompletedNCT00068146
26Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
27RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing VasculitidesCompletedNCT00307593
28Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
29Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
30Study of Autoimmune Lymphoproliferative Syndrome (ALPS)RecruitingNCT00001350
31VCRC Tissue RepositoryRecruitingNCT02967068
32Pediatric Vasculitis InitiativeRecruitingNCT02006134
33Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood DisordersRecruitingNCT01758042
34American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
35One-Time DNA Study for VasculitisRecruitingNCT01241305
36Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)RecruitingNCT00315380
37Analysis of Patients Treated for Chronic Granulomatous Disease Since January 1, 1995RecruitingNCT02116764
38Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune SystemRecruitingNCT01063309
39Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995RecruitingNCT02082353
40Vasculitis Pregnancy RegistryRecruitingNCT02593565
41Investigation of Immune Disorders and DeficienciesActive, not recruitingNCT01981785
42PRO Development for ANCA Associated VasculitisActive, not recruitingNCT01729624
43The ANCA Vasculitis Questionnaire (AAV-PRO©)Active, not recruitingNCT02507024
44Comparative Autoantibody and Immunologic Cell Marker StudyEnrolling by invitationNCT02422875
45VCRC Patient Contact Registry Patient-Reported Data Validation StudyEnrolling by invitationNCT02190942
46Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss SyndromeNot yet recruitingNCT02728271Early Phase 1
47Clinical Transcriptomics in Systemic Vasculitis (CUTIS)Not yet recruitingNCT03004326
48Fluorodeoxyglucose Imaging Studies to Detect LymphomaWithdrawnNCT01672918

Search NIH Clinical Center for Autoimmune Lymphoproliferative Syndrome


Cochrane evidence based reviews: autoimmune lymphoproliferative syndrome

Genetic Tests for Autoimmune Lymphoproliferative Syndrome

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Genetic tests related to Autoimmune Lymphoproliferative Syndrome:

id Genetic test Affiliating Genes
1 Autoimmune Lymphoproliferative Syndrome26 24 FASLG
2 Autoimmune Lymphoproliferative Syndrome, Type 1b26
3 Autoimmune Lymphoproliferative Syndrome, Type 1a26
4 Autoimmune Lymphoproliferative Syndrome, Type Ia24
5 Autoimmune Lymphoproliferative Syndrome, Type Ib24

Anatomical Context for Autoimmune Lymphoproliferative Syndrome

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MalaCards organs/tissues related to Autoimmune Lymphoproliferative Syndrome:

35
Lymph node, Spleen, Liver, Kidney, T cells, Eye, Skin

Animal Models for Autoimmune Lymphoproliferative Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Lymphoproliferative Syndrome:

40 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.1BCL2L11, FADD, HRAS, IL10, IL2, NRAS
2MP:00053677.8BCL2L11, CASP8, FAS, FASLG, HRAS, PRKCD
3MP:00107717.7BCL2L11, CASP8, CTLA4, FAS, FASLG, HRAS
4MP:00053887.6CASP8, CTLA4, FAS, FASLG, HRAS, IL10
5MP:00028737.6BCL2L11, CTLA4, FAS, FASLG, HRAS, IL10
6MP:00053907.6CTLA4, FADD, FAS, FASLG, HRAS, IL10
7MP:00053707.4CASP8, CTLA4, FADD, FAS, FASLG, IL10
8MP:00053847.2BCL2L11, CASP8, FADD, FAS, FASLG, IL10
9MP:00020067.2BCL2L11, CASP8, FAS, FASLG, HRAS, IL10
10MP:00036316.9BCL2L11, CASP8, FADD, FAS, FASLG, HRAS
11MP:00053816.8CTLA4, FADD, FAS, FASLG, IL10, IL2
12MP:00053796.4BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
13MP:00053786.3BCL2L11, CASP8, FADD, FAS, HRAS, IL10
14MP:00053856.3BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
15MP:00053876.1BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
16MP:00053976.0BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
17MP:00107685.8BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG
18MP:00053765.7BCL2L11, CASP8, CTLA4, FADD, FAS, FASLG

Publications for Autoimmune Lymphoproliferative Syndrome

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Articles related to Autoimmune Lymphoproliferative Syndrome:

(show top 50)    (show all 190)
idTitleAuthorsYear
1
Unexplained lymphadenopathies: autoimmune lymphoproliferative syndrome in an adult patient. (27979843)
2016
2
Pulmonary Manifestations of the Autoimmune Lymphoproliferative Syndrome. A Retrospective Study of a Unique Patient Cohort. (27268092)
2016
3
Autoimmune Lymphoproliferative Syndrome: A Rare Cause of Disappearing HDL Syndrome. (27579193)
2016
4
Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome. (27845235)
2016
5
FAS Haploinsufficiency Caused by Extracellular Missense Mutations Underlying Autoimmune Lymphoproliferative Syndrome. (26563159)
2015
6
Approaches to Managing Autoimmune Cytopenias in Novel Immunological Disorders with Genetic Underpinnings Like Autoimmune Lymphoproliferative Syndrome. (26258116)
2015
7
Decreased activation-induced cell death by EBV-transformed B cells from a patient with autoimmune lymphoproliferative syndrome caused by a novel FASLG mutation. (26334989)
2015
8
Autoimmune lymphoproliferative syndrome-like disease in patients with LRBA mutation. (25931386)
2015
9
Adult onset autoimmune lymphoproliferative syndrome due to somatic FAS mutation. (25827517)
2015
10
Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS). (25663566)
2015
11
Autoimmune lymphoproliferative syndrome with neonatal onset. (24906264)
2014
12
Autoimmune lymphoproliferative syndrome in pregnancy: A case of favorable mother-fetal outcome in a well-controlled disease. (25302402)
2014
13
Variations of the UNC13D gene in patients with autoimmune lymphoproliferative syndrome. (23840885)
2013
14
Autoimmune pancreatitis in the autoimmune lymphoproliferative syndrome (ALPS): a sheep in wolves' clothing? (23407489)
2013
15
Tubulointerstitial nephritis in a patient with probable autoimmune lymphoproliferative syndrome. (23588339)
2013
16
A missense mutation in the extracellular domain of Fas: the most common change in Argentinean patients with autoimmune lymphoproliferative syndrome represents a founder effect. (22752343)
2012
17
Thymic functions and gene expression profile distinct double-negative cells from single positive cells in the autoimmune lymphoproliferative syndrome. (22273982)
2012
18
Elevated vitamin Ba88a88 levels in autoimmune lymphoproliferative syndrome attributable to elevated haptocorrin in lymphocytes. (22306884)
2012
19
New advances in the diagnosis and treatment of autoimmune lymphoproliferative syndrome. (22157362)
2012
20
A survey of 90 patients with autoimmune lymphoproliferative syndrome related to TNFRSF6 mutation. (21885602)
2011
21
Pentostatin for treatment of refractory autoimmune lymphoproliferative syndrome. (21495163)
2011
22
Accessory spleen: differential diagnosis for lymphoma in autoimmune lymphoproliferative syndrome. (20162683)
2010
23
Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome. (20227752)
2010
24
Advances in the management and understanding of autoimmune lymphoproliferative syndrome (ALPS). (19930184)
2010
25
Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation. (18948840)
2009
26
Use of rituximab for refractory cytopenias associated with autoimmune lymphoproliferative syndrome (ALPS). (19214977)
2009
27
Autoimmune lymphoproliferative syndrome (ALPS): a rare cause of immune cytopenia. (18310796)
2008
28
Autoimmune lymphoproliferative syndrome (ALPS) caused by Fas (CD95) mutation mimicking sarcoidosis. (18223337)
2008
29
Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS). (16757690)
2006
30
Causes and consequences of the autoimmune lymphoproliferative syndrome. (16522544)
2006
31
Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS). (15542578)
2005
32
Histologic features of sinus histiocytosis with massive lymphadenopathy in patients with autoimmune lymphoproliferative syndrome. (15958855)
2005
33
Positron emission tomography scan findings of autoimmune lymphoproliferative syndrome. (15193245)
2004
34
Autoimmune lymphoproliferative syndrome with somatic Fas mutations. (15459302)
2004
35
Common expression of an unusual CD45 isoform on T cells from patients with large granular lymphocyte leukaemia and autoimmune lymphoproliferative syndrome. (12492582)
2003
36
Dominant expression of interleukin 10 but not interferon gamma in CD4(-)CD8(-)alphabetaT cells of autoimmune lymphoproliferative syndrome. (12406097)
2002
37
A composite picture of TcR alpha/beta(+) CD4(-)CD8(-) T Cells (alpha/beta-DNTCs) in humans with autoimmune lymphoproliferative syndrome. (12139944)
2002
38
Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations. (11918552)
2002
39
Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome. (11588044)
2001
40
Autoimmune lymphoproliferative syndrome type III: an indefinite disorder. (11342357)
2001
41
Diffuse large B-cell non-Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome. (11380411)
2001
42
The autoimmune lymphoproliferative syndrome. A disorder of human lymphocyte apoptosis. (11269222)
2001
43
Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression. (11342444)
2001
44
Autoimmune lymphoproliferative syndrome (ALPS) in a child from consanguineous parents: a dominant or recessive disease? (10709732)
2000
45
Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. (10802504)
2000
46
Expression in transgenic mice of dominant interfering Fas mutations: a model for human autoimmune lymphoproliferative syndrome. (10497009)
1999
47
An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome. (10189330)
1999
48
Autoimmune lymphoproliferative syndrome, a disorder of apoptosis. (10590910)
1999
49
Reversible monoclonal lymphadenopathy in autoimmune lymphoproliferative syndrome with functional FAS (CD95/APO-1) deficiency. (10403307)
1999
50
Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. (9028321)
1997

Variations for Autoimmune Lymphoproliferative Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Autoimmune Lymphoproliferative Syndrome:

69 (show all 23)
id Symbol AA change Variation ID SNP ID
1FASLGp.Cys202SerVAR_075568
2FASp.Thr28AlaVAR_013417
3FASp.Cys82ArgVAR_013418
4FASp.Arg121TrpVAR_013419rs121913078
5FASp.Tyr232CysVAR_013423rs121913079
6FASp.Thr241LysVAR_013424rs201072885
7FASp.Thr241ProVAR_013425rs121913076
8FASp.Arg250ProVAR_013426rs121913080
9FASp.Arg250GlnVAR_013427
10FASp.Ala257AspVAR_013428
11FASp.Asp260GlyVAR_013429
12FASp.Asp260TyrVAR_013430rs121913086
13FASp.Asp260ValVAR_013431rs28929498
14FASp.Thr270IleVAR_013433rs121913081
15FASp.Glu272GlyVAR_013434
16FASp.Glu272LysVAR_013435
17FASp.Ile310SerVAR_013438
18FASp.Ile262SerVAR_058910
19FASp.Val249LeuVAR_065128
20FASp.Gly253AspVAR_065129
21FASp.Gly253SerVAR_065130
22FASp.Ile259ArgVAR_065131
23FASp.Thr270LysVAR_065132

Clinvar genetic disease variations for Autoimmune Lymphoproliferative Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FASLGNM_000639.2(FASLG): c.263delT (p.Phe88Serfs)deletionPathogenicrs587776450GRCh37Chr 1, 172628604: 172628604
2FASLGNM_000639.2(FASLG): c.466A> G (p.Arg156Gly)SNVPathogenicrs80358238GRCh37Chr 1, 172634776: 172634776

Expression for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Search GEO for disease gene expression data for Autoimmune Lymphoproliferative Syndrome.

Pathways for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Pathways related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 44)
idSuper pathwaysScoreTop Affiliating Genes
19.8FAS, FASLG, IL10
29.5CASP10, CASP8, FADD, FAS
3
Show member pathways
9.3CASP10, CASP8, FADD, FAS, FASLG
49.3CASP10, CASP8, FADD, FAS, FASLG
59.2CASP8, HRAS, NRAS, PRKCD
69.1BCL2L11, CASP8, FADD, FAS, FASLG
7
Show member pathways
9.0CASP10, CASP8, HRAS, NRAS, PRKCD
8
Show member pathways
9.0CTLA4, FASLG, IL2, IL2RA
99.0IL2, IL2RA, STAT3
108.9HRAS, NRAS, PRKCD, STAT3
11
Show member pathways
8.9BCL2L11, CASP10, CASP8, FADD, FAS, FASLG
12
Show member pathways
8.9BCL2L11, CASP8, FADD, FAS, FASLG, PRKCD
138.9IL10, IL2, IL2RA, PTPRC
148.9IL10, IL2, IL2RA, PTPRC
158.8CASP8, FAS, FASLG, HRAS, NRAS, PRKCD
16
Show member pathways
8.8FAS, FASLG, IL10, IL2, IL2RA
17
Show member pathways
8.8FASLG, IL2, IL2RA, STAT3
188.8FAS, FASLG, HRAS, NRAS, STAT3
19
Show member pathways
8.7CASP10, CASP8, FADD, HRAS, NRAS, PRKCD
20
Show member pathways
8.7CASP8, IL2, IL2RA, STAT3
21
Show member pathways
8.7FAS, FASLG, HRAS, IL2, NRAS
22
Show member pathways
8.6CTLA4, IL2, IL2RA, PRKCD, PTPRC
23
Show member pathways
8.6CASP10, CASP8, FADD, FAS, FASLG, HRAS
24
Show member pathways
8.5FAS, FASLG, HRAS, NRAS, PRKCD, STAT3
25
Show member pathways
8.5FAS, FASLG, HRAS, NRAS, PRKCD, STAT3
268.4IL10, IL2, IL2RA, PRKCD, STAT3
278.3CASP8, FADD, FAS, FASLG, HRAS, NRAS
28
Show member pathways
8.2BCL2L11, FASLG, HRAS, IL10, NRAS, STAT3
29
Show member pathways
8.1BCL2L11, CASP10, CASP8, FADD, FAS, FASLG
30
Show member pathways
8.0CASP8, FADD, FAS, FASLG, IL2, IL2RA
31
Show member pathways
8.0CASP10, CASP8, FADD, FAS, FASLG, HRAS
328.0BCL2L11, FASLG, HRAS, IL2, IL2RA, NRAS
33
Show member pathways
8.0CASP10, CASP8, HRAS, IL2, IL2RA, NRAS
34
Show member pathways
7.8CASP8, CTLA4, FADD, FAS, FASLG, IL10
35
Show member pathways
7.7CTLA4, FAS, HRAS, IL10, IL2, NRAS
367.6CTLA4, FAS, FASLG, IL10, IL2, IL2RA
37
Show member pathways
7.6HRAS, IL10, IL2, IL2RA, NRAS, PRKCD
38
Show member pathways
7.1CASP10, CASP8, FADD, FAS, FASLG, HRAS
39
Show member pathways
7.0FADD, FAS, FASLG, HRAS, IL10, IL2
40
Show member pathways
7.0CASP10, CASP8, FAS, FASLG, HRAS, IL10
41
Show member pathways
6.9BCL2L11, CASP10, CASP8, FADD, FAS, FASLG
42
Show member pathways
6.8CASP10, CASP8, FAS, FASLG, HRAS, IL10
43
Show member pathways
6.4CASP10, CASP8, CTLA4, FADD, FASLG, HRAS
44
Show member pathways
6.1BCL2L11, CASP10, CASP8, FADD, FAS, FASLG

GO Terms for genes affiliated with Autoimmune Lymphoproliferative Syndrome

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Cellular components related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:003126410.4CASP8, FADD, FAS
2ripoptosomeGO:009734210.4CASP10, CASP8, FADD
3CD95 death-inducing signaling complexGO:003126510.2CASP10, CASP8, FADD, FAS
4external side of plasma membraneGO:00098979.4CTLA4, FAS, FASLG, IL2RA, PTPRC
5membrane raftGO:00451219.4CASP8, FADD, FAS, FASLG, PTPRC
6plasma membraneGO:00058866.9CTLA4, FADD, FAS, FASLG, HRAS, IL2RA

Biological processes related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.8FAS, FASLG
2motor neuron apoptotic processGO:009704910.8FADD, FAS
3TRAIL-activated apoptotic signaling pathwayGO:003646210.6CASP8, FADD
4death-inducing signaling complex assemblyGO:007155010.6CASP8, FADD
5positive regulation of macrophage differentiationGO:004565110.6CASP8, FADD
6activation of cysteine-type endopeptidase activityGO:009720210.5CASP8, FADD
7necroptotic signaling pathwayGO:009752710.5FADD, FAS, FASLG
8positive regulation of protein homooligomerizationGO:003246410.5BCL2L11, FAS
9negative regulation of B cell proliferationGO:003088910.4CTLA4, IL10
10negative regulation of immune responseGO:005077710.4CTLA4, IL2RA
11cellular response to mechanical stimulusGO:007126010.3CASP8, FADD, FAS
12activation-induced cell death of T cellsGO:000692410.3FAS, IL2RA
13regulation of T cell homeostatic proliferationGO:004601310.2IL2, IL2RA
14negative regulation of lymphocyte proliferationGO:005067210.2IL2, IL2RA
15activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.2CASP8, FADD, FAS, FASLG
16B cell proliferationGO:004210010.2IL10, PRKCD, PTPRC
17regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.2CASP8, FADD, FAS, FASLG
18extrinsic apoptotic signaling pathwayGO:009719110.2CASP8, FADD, FAS, FASLG
19spleen developmentGO:004853610.1BCL2L11, FADD, FAS
20negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.1CASP8, FADD, FAS, FASLG
21positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.1CASP10, CASP8, FADD, FASLG
22positive regulation of T cell differentiationGO:004558210.0IL2, IL2RA
23stimulatory C-type lectin receptor signaling pathwayGO:000222310.0HRAS, NRAS, PRKCD
24protein heterooligomerizationGO:005129110.0CASP8, FADD, HRAS
25response to lipopolysaccharideGO:003249610.0CASP8, FAS, FASLG, IL10
26negative regulation of T cell proliferationGO:00421309.9CTLA4, IL10, IL2RA
27extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.9CASP10, FADD, FAS, FASLG
28activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.9CASP8, FADD, FAS, FASLG
29positive regulation of activated T cell proliferationGO:00421049.9FADD, IL2, IL2RA
30T cell homeostasisGO:00430299.8BCL2L11, FADD, FAS, IL2RA
31positive regulation of interferon-gamma productionGO:00327299.7FADD, HRAS, IL2
32positive regulation of T cell proliferationGO:00421029.5IL2, IL2RA, PTPRC
33negative regulation of inflammatory responseGO:00507289.5IL10, IL2, IL2RA, PRKCD
34extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.5BCL2L11, FADD, FAS, IL2
35apoptotic signaling pathwayGO:00971909.2CASP10, CASP8, FADD, FAS, FASLG
36positive regulation of apoptotic processGO:00430659.1BCL2L11, CTLA4, FADD, FAS, FASLG
37MAPK cascadeGO:00001658.8HRAS, IL2, IL2RA, NRAS
38cell surface receptor signaling pathwayGO:00071668.8CASP10, CASP8, FADD, HRAS, IL2RA, PTPRC
39immune responseGO:00069558.7CTLA4, FAS, FASLG, IL10, IL2, IL2RA
40apoptotic processGO:00069157.8BCL2L11, CASP10, CASP8, FADD, FAS, FASLG

Molecular functions related to Autoimmune Lymphoproliferative Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009719910.4CASP10, CASP8
2death effector domain bindingGO:003587710.2CASP10, CASP8, FADD
3tumor necrosis factor receptor bindingGO:000516410.2CASP8, FADD, FASLG
4death receptor bindingGO:000512310.0CASP8, FADD, FASLG
5protein complex bindingGO:00324039.5CASP8, FADD, FAS, NRAS

Sources for Autoimmune Lymphoproliferative Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet