MCID: ATM022
MIFTS: 40

Autoimmune Myocarditis malady

Summaries for Autoimmune Myocarditis

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33MalaCards
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MalaCards: Autoimmune Myocarditis is related to thyroiditis and celiac disease. An important gene associated with Autoimmune Myocarditis is ICOS (inducible T-cell co-stimulator), and among its related pathways are Rheumatoid arthritis and CD28 co-stimulation. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thymus and heart, and related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Autoimmune Myocarditis

Sources:
43NIH Rare Diseases
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Aliases & Descriptions:

autoimmune myocarditis 43


Related Diseases for Autoimmune Myocarditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the myocarditis family:

acute myocarditis autoimmune myocarditis
infectious myocarditis post-infectious myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis30.0CTLA4, CIITA
2celiac disease30.0CTLA4, CIITA
3autoimmune thyroiditis30.0CIITA, ITGB2, CTLA4
4acute myocarditis10.6
5giant cell myocarditis10.2
6rheumatic myocarditis10.0
7interstitial myocarditis10.0
8stress cardiomyopathy10.0
9klebsiella10.0
10m�ni�re disease10.0
11hypoxia10.0
12rheumatic disease10.0
13nephritis10.0LCN2
14hepatitis10.0CTLA4
15bronchopulmonary dysplasia10.0TXN
16myeloid leukemia10.0ITGB2
17goiter10.0CIITA
18allergic rhinitis10.0CTLA4
19adult t-cell leukemia10.0TXN
20kawasaki disease10.0CIITA
21glaucoma10.0TGFB2
22hypertrophic cardiomyopathy10.0MYH6
23cerebrovascular disease10.0AGTR1
24retinal detachment10.0TGFB2
25vascular disease10.0TXN, LCN2
26peritonitis10.0CXCL2, ITGB2
27alopecia areata10.0CIITA
28polycythemia10.0EPO
29hypertensive encephalopathy10.0EPO
30sjogren's syndrome10.0CIITA
31colorectal cancer10.0TXN, TGFB2
32addison's disease10.0CTLA4
33primary pulmonary hypertension10.0NPPA
34fatty liver disease10.0PPARA
35mitral valve disease10.0NPPA
36thalassemia10.0EPO
37pancreatic cancer10.0LCN2, TGFB2
38colon cancer10.0TXN, PPARA
39infertility10.0TGFB2
40myopathy10.0PPARA, MYH6
41nephrotic syndrome10.0NPPA
42obesity10.0LCN2, PPARA
43influenza10.0TXN, CIITA, TNFSF9
44diabetic retinopathy10.0TGFB2, AGTR1
45adenoma10.0PPARA, CTLA4
46uveitis10.0CTLA4, TGFB2
47lymphopenia10.0ITGB2, CIITA
48tuberculosis10.0IL12RB1, CIITA, ITGB2
49sarcoidosis10.0TGFB2, IL12RB1, TXN
50hypothyroidism10.0MYH6, CTLA4

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Clinical Features for Autoimmune Myocarditis

Drugs & Therapeutics for Autoimmune Myocarditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Myocarditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Myocarditis

Search NIH Clinical Center for Autoimmune Myocarditis

Search CenterWatch for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Autoimmune Myocarditis:

33
Bone marrow, Thymus, Heart, Thyroid, Monocytes, T cells, B cells, Fetal thyroid

Animal Models for Autoimmune Myocarditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Autoimmune Myocarditis

Sources:
51PubMed
See all sources

Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis. (24189626)
2014
2
Inhibition of NF-I_B activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation. (24097428)
2013
3
Immune-mediated and autoimmune myocarditis: clinical presentation, diagnosis and management. (23114995)
2013
4
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
5
Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling. (22145946)
2012
6
Hyperthyroidism induced autoimmune myocarditis. Evaluation by cardiovascular magnetic resonance and endomyocardial biopsy. (22592022)
2012
7
Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. (22542793)
2012
8
Suppressor of cytokine signaling 1 DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis. (22798678)
2012
9
Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4(+) T cells. (22774982)
2012
10
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. (21928275)
2011
11
Novel nonmajor histocompatibility complex-linked loci from mouse chromosome 17 confer susceptibility to viral-mediated chronic autoimmune myocarditis. (20729557)
2010
12
Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis. (18608177)
2009
13
Long-term carperitide treatment attenuates left ventricular remodeling in rats with heart failure after autoimmune myocarditis. (19668089)
2009
14
Effects of angiotensin-II receptor blockers on experimental autoimmune myocarditis. (19896742)
2009
15
Genetic complexity of autoimmune myocarditis. (18190873)
2008
16
Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer. (18441464)
2008
17
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
18
Fusidin ameliorates experimental autoimmune myocarditis in rats by inhibiting TNF-alpha production. (17663192)
2007
19
Resveratrol ameliorates experimental autoimmune myocarditis. (17322642)
2007
20
Erythropoietin attenuates the development of experimental autoimmune myocarditis. (17297593)
2007
21
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. (16698032)
2006
22
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis. (17039570)
2006
23
Immune tolerance to cardiac myosin induced by anti-CD4 monoclonal antibody in autoimmune myocarditis rats. (16783461)
2006
24
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. (16316965)
2005
25
Delayed contrast-enhanced magnetic resonance imaging for the detection of autoimmune myocarditis and long-term follow-up. (15881537)
2005
26
Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. (15698832)
2005
27
Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines. (15774858)
2005
28
Effect of hydrodynamics-based gene delivery of plasmid DNA encoding interleukin-1 receptor antagonist-Ig for treatment of rat autoimmune myocarditis: possible mechanism for lymphocytes and noncardiac cells. (15795329)
2005
29
Immunoglobulin treatment suppressed adoptively transferred autoimmune myocarditis in severe combined immunodeficient mice. (15308483)
2004
30
An in vivo model of autoimmune post-coxsackievirus B3 myocarditis in severe combined immunodeficiency mouse. (14613869)
2003
31
Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. (12566416)
2003
32
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. (11748115)
2001
33
Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction. (11136679)
2001
34
Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation. (11535562)
2001
35
The effect of intravenous immunoglobulins on the progression of experimental autoimmune myocarditis in the rat. (11502097)
2001
36
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
37
Expression of coxsackievirus and adenovirus receptor in hearts of rats with experimental autoimmune myocarditis. (10679478)
2000
38
Postpartum onset of acute heart failure possibly due to postpartum autoimmune myocarditis. A report of three cases. (10081523)
1999
39
An inhibitor of inducible nitric oxide synthase ameliorates experimental autoimmune myocarditis in Lewis rats. (9916888)
1998
40
The Fas/Fas ligand system is involved in the pathogenesis of autoimmune myocarditis in rats. (9794399)
1998
41
Cellular and molecular mechanisms of murine autoimmune myocarditis. (9063494)
1997
42
Induction of autoimmune myocarditis in interleukin-2-deficient mice. (9107162)
1997
43
Autoimmune myocarditis. (8803682)
1996
44
A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells. (7633659)
1995
45
Effects of 15-deoxyspergualin on experimental autoimmune giant cell myocarditis of the rat. (7850949)
1995
46
Experimental autoimmune myocarditis: a suitable model to study neuroimmune crosstalk. (8729293)
1995
47
Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice. (18475540)
1993
48
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. (8228830)
1993
49
Lymphocytes infiltration induces dysfunction in autoimmune myocarditis: role of SRS-A. (3260962)
1988
50
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987

Genetic Variations for Autoimmune Myocarditis

Expression for genes affiliated with Autoimmune Myocarditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

Sources:
30KEGG, 54Reactome, 52QIAGEN
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Pathways related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ITGB2, CTLA4
2
Hide members
9.9CD274, CTLA4, ICOS
3
Hide members
9.8ITGB2, CIITA, IL12RB1, TGFB2
49.7ICOS, CTLA4, ITGB2, CD274
5
Hide members
9.5IL12RB1, ICOS, CTLA4, ITGB2, CIITA, MYH6
6
Hide members
9.3TNFRSF9, TNFSF9, MYH6, CXCL2, IL12RB1, TGFB2
7
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9.2TNFRSF9, TNFSF9, ITGB2, CXCL2, IL12RB1, TGFB2
8
Hide members
9.2PSMC4, ITGB2, AGTR1, EPO, IL12RB1, TGFB2
9
Hide members
9.1TNFRSF9, TNFSF9, ITGB2, MYH6, CXCL2, IL12RB1
10
Hide members
9.0TNFRSF9, TNFSF9, PSMC4, PPARA, CXCL2, IL12RB1
11
Hide members
8.6TXN, ICOS, PSMC4, CTLA4, ITGB2, CIITA

Compounds for genes affiliated with Autoimmune Myocarditis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1pge24510.6CXCL2
2estrogen4510.5CXCL2, MYH6
3glutamate4510.3PPARA, ITGB2, AGTR1
4rantes4510.3ITGB2, CXCL2, CIITA
5mptp4510.3TXN
6enalapril45 50 1112.2NPPA, AGTR1, EPO
7h2o24510.2PPARA, ITGB2, CXCL2
8indomethacin45 60 29 1113.2PPARA, VASP, SPP1
9mycophenolate mofetil45 50 1112.1SPP1, EPO, CTLA4
108-oxo-dg4510.1TXN, AGTR1, CXCL2
11ibmx45 29 6012.1NPPA, ITGB2, CIITA, PPARA
12tgf beta14510.1AGTR1, CTLA4, TGFB2, SPP1
13simvastatin45 50 60 29 11 2415.0PPARA, ITGB2, CIITA, AGTR1
14glucose4510.0AGTR1, TGFB2, PSMC4, MYH6
15carnitine4510.0EPO, MYH6, PPARA, TXN
16isoproterenol45 1111.0MYH6, NPPA, ITGB2, AGTR1
17nicotinamide45 1111.0CIITA, EPO, TXN
18hyaluronic acid45 2411.0CXCL2, ITGB2, TGFB2, SPP1
19ionomycin459.9IL12RB1, ITGB2, TNFRSF9, CTLA4, CD274
20calcitriol45 60 11 2412.8PPARA, TGFB2, EPO, SPP1
21prostaglandin459.8NPPA, TGFB2, AGTR1, CXCL2
22prostacyclin459.8NPPA, VASP, PPARA, AGTR1
23cgmp45 2910.8VASP, AGTR1, NPPA, LCN2
24actinomycin d459.8PPARA, SPP1, AGTR1, CIITA, TXN
25cholesterol45 29 11 2412.7ITGB2, PPARA, CTLA4, CIITA, AGTR1, SPP1
26wortmannin459.7ITGB2, CTLA4, CXCL2, SPP1, PSMC4
27oligonucleotide459.6CIITA, CXCL2, MYH6, SPP1, ITGB2, TGFB2
28genistein45 29 60 2 11 2414.6PPARA, PSMC4, ITGB2, AGTR1, SPP1, TGFB2
29cyclosporin a45 29 6011.6ITGB2, CTLA4, PSMC4, TXN, CIITA, TGFB2
30vitamin a45 11 2411.6TGFB2, TXN, LCN2
31testosterone45 60 11 2412.5TXN, NPPA, SPP1, PPARA, EPO, TGFB2
32ly294002459.5SPP1, EPO, ITGB2, CTLA4, PSMC4, CXCL2
33oxygen45 2410.5CXCL2, MYH6, CIITA, TXN, EPO, PSMC4
34arginine459.5NPPA, TXN, ITGB2, AGTR1, MYH6, SPP1
35fibrinogen459.5AGTR1, LCN2, CXCL2, ITGB2, VASP, SPP1
36cisplatin45 50 60 1112.4PPARA, TXN, SPP1, EPO, AGTR1
37lactate459.4ITGB2, EPO, TXN, CXCL2, SPP1
38vitamin d459.3SPP1, PPARA, TXN, TGFB2, EPO, AGTR1
39phosphatidylinositol459.3PSMC4, ITGB2, TGFB2, SPP1, EPO, AGTR1
40superoxide45 2410.2SPP1, LCN2, AGTR1, TXN
41alanine459.2SPP1, PSMC4, TXN, AGTR1, PPARA, ITGB2
42dexamethasone45 50 29 1112.1SPP1, TGFB2, CXCL2, CIITA, TNFRSF9, ITGB2
43lipid459.0PPARA, ITGB2, CIITA, AGTR1, CXCL2, MYH6
44cysteine459.0AGTR1, CIITA, ITGB2, PSMC4, TXN, TNFRSF9
45creatinine459.0TGFB2, EPO, AGTR1, SPP1, ITGB2, PPARA
46vegf458.7TGFB2, SPP1, CXCL2, TXN, NPPA, PSMC4
47serine458.7MYH6, PPARA, PSMC4, VASP, AGTR1, CIITA
48nitric oxide45 11 2410.5VASP, AGTR1, CD274, NPPA, PSMC4, TGFB2
49tyrosine458.0TGFB2, CIITA, ITGB2, PSMC4, SPP1, CTLA4
50calcium45 50 11 2411.0AGTR1, VASP, LCN2, TNFRSF9, NPPA, PSMC4

GO Terms for genes affiliated with Autoimmune Myocarditis

Sources:
16Gene Ontology
See all sources

Cellular components related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2ICOS, TNFRSF9, CTLA4, CD274, IL12RB1
2extracellular regionGO:0055768.7LCN2, ICOS, NPPA, EPO, CXCL2, SPP1
3extracellular spaceGO:0056158.5TGFB2, LCN2, TNFRSF9, TNFSF9, NPPA, EPO

Biological processes related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil chemotaxisGO:03059310.0ITGB2, SPP1, TGFB2
2protein homotrimerizationGO:0702079.9TNFRSF9, LCN2
3T cell costimulationGO:0312959.8CD274, CTLA4, ICOS
4immune responseGO:0069559.3CXCL2, CD274, CIITA, CTLA4, TNFSF9, ICOS
5cell-cell signalingGO:0072679.3TXN, TNFSF9, ITGB2, TGFB2
6apoptotic processGO:0069158.9LCN2, TNFRSF9, TNFSF9, PSMC4, ITGB2, EPO

Products for genes affiliated with Autoimmune Myocarditis

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  • Proteins
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  • Antibodies

Sources for Autoimmune Myocarditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet