MCID: ATM022
MIFTS: 30

Autoimmune Myocarditis malady

Summaries for Autoimmune Myocarditis

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32MalaCards
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MalaCards: Autoimmune Myocarditis is related to myocarditis and dilated cardiomyopathy. An important gene associated with Autoimmune Myocarditis is ICOS (inducible T-cell co-stimulator), and among its related pathways are Rheumatoid arthritis and CD28 co-stimulation. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are renal/urinary system and integument.

Aliases & Classifications for Autoimmune Myocarditis

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42NIH Rare Diseases
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Aliases & Descriptions:

autoimmune myocarditis 42


Related Diseases for Autoimmune Myocarditis

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17GeneCards, 18GeneDecks
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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.9TXN, CIITA, MYH6, IL12RB1
2dilated cardiomyopathy30.6TXN, NPPA, MYH6
3myocardial infarction30.2NPPA, CIITA, AGTR1
4thyroiditis30.0CTLA4, CIITA
5celiac disease30.0CIITA, CTLA4
6autoimmune thyroiditis30.0CIITA, ITGB2, CTLA4
7pneumonia30.0TXN, PPARA, CXCL2, TGFB2
8acute myocarditis10.6
9periodontitis10.2
10rheumatic myocarditis10.0
11interstitial myocarditis10.0
12hyperthyroidism10.0
13severe combined immunodeficiency10.0
14t cell deficiency10.0
15nephritis10.0LCN2
16hepatitis10.0CTLA4
17bronchopulmonary dysplasia10.0TXN
18myeloid leukemia10.0ITGB2
19goiter10.0CIITA
20allergic rhinitis10.0CTLA4
21adult t-cell leukemia10.0TXN
22kawasaki disease10.0CIITA
23glaucoma10.0TGFB2
24hypertrophic cardiomyopathy10.0MYH6
25cerebrovascular disease10.0AGTR1
26retinal detachment10.0TGFB2
27vascular disease10.0LCN2, TXN
28peritonitis10.0CXCL2, ITGB2
29alopecia areata10.0CIITA
30polycythemia10.0EPO
31hypertensive encephalopathy10.0EPO
32sjogren's syndrome10.0CIITA
33colorectal cancer10.0TGFB2, TXN
34addison's disease10.0CTLA4
35primary pulmonary hypertension10.0NPPA
36fatty liver disease10.0PPARA
37mitral valve disease10.0NPPA
38alpha thalassemia10.0EPO
39pancreatic cancer10.0LCN2, TGFB2
40colon cancer10.0PPARA, TXN
41infertility10.0TGFB2
42myopathy10.0MYH6, PPARA
43nephrotic syndrome10.0NPPA
44obesity10.0LCN2, PPARA
45influenza10.0TXN, TNFSF9, CIITA
46diabetic retinopathy10.0TGFB2, AGTR1
47adenoma10.0PPARA, CTLA4
48uveitis10.0CTLA4, TGFB2
49lymphopenia10.0CIITA, ITGB2
50tuberculosis10.0IL12RB1, CIITA, ITGB2

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Clinical Features for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Autoimmune Myocarditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Myocarditis

Search NIH Clinical Center for Autoimmune Myocarditis

Search CenterWatch for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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Animal Models for Autoimmune Myocarditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.6TGFB2, SPP1, AGTR1, LCN2
2MP:00107719.2TNFRSF9, CTLA4, PPARA, ITGB2, SPP1
3MP:00053858.4NPPA, CTLA4, PPARA, ITGB2, AGTR1, MYH6
4MP:00053977.7LCN2, ICOS, TNFRSF9, NPPA, PSMC4, CTLA4
5MP:00053847.7CTLA4, TNFRSF9, ICOS, LCN2, TXN, PPARA
6MP:00053877.7TGFB2, LCN2, ICOS, TNFRSF9, TNFSF9, PSMC4
7MP:00053767.6ITGB2, PPARA, CTLA4, NPPA, ICOS, LCN2
8MP:00107687.3PPARA, CTLA4, PSMC4, TNFRSF9, LCN2, TXN

Publications for Autoimmune Myocarditis

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Genetic Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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29KEGG, 53Reactome, 51QIAGEN
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Pathways related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1ITGB2, CTLA4
2
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9.9CD274, CTLA4, ICOS
3
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9.8ITGB2, CIITA, IL12RB1, TGFB2
49.7ICOS, CTLA4, ITGB2, CD274
5
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9.5IL12RB1, ICOS, CTLA4, ITGB2, CIITA, MYH6
6
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9.3TNFRSF9, TNFSF9, MYH6, CXCL2, IL12RB1, TGFB2
7
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9.2TNFRSF9, TNFSF9, ITGB2, CXCL2, IL12RB1, TGFB2
8
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9.2PSMC4, ITGB2, AGTR1, EPO, IL12RB1, TGFB2
9
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9.1TNFRSF9, TNFSF9, ITGB2, MYH6, CXCL2, IL12RB1
10
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9.0TNFRSF9, TNFSF9, PSMC4, PPARA, CXCL2, IL12RB1
11
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8.6TXN, ICOS, PSMC4, CTLA4, ITGB2, CIITA

Compounds for genes affiliated with Autoimmune Myocarditis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

(show top 50)    (show all 78)
idCompoundScoreTop Affiliating Genes
1pge24410.6CXCL2
2estrogen4410.5CXCL2, MYH6
3glutamate4410.3PPARA, ITGB2, AGTR1
4rantes4410.3ITGB2, CXCL2, CIITA
5mptp4410.3TXN
6enalapril44 49 1112.2NPPA, AGTR1, EPO
7h2o24410.2PPARA, ITGB2, CXCL2
8indomethacin44 59 28 1113.2PPARA, VASP, SPP1
9mycophenolate mofetil44 49 1112.1SPP1, EPO, CTLA4
108-oxo-dg4410.1TXN, AGTR1, CXCL2
11ibmx44 28 5912.1NPPA, ITGB2, CIITA, PPARA
12tgf beta14410.1AGTR1, CTLA4, TGFB2, SPP1
13simvastatin44 49 59 28 11 2415.0PPARA, ITGB2, CIITA, AGTR1
14glucose4410.0AGTR1, TGFB2, PSMC4, MYH6
15carnitine4410.0EPO, MYH6, PPARA, TXN
16isoproterenol44 1111.0MYH6, NPPA, ITGB2, AGTR1
17nicotinamide44 1111.0CIITA, EPO, TXN
18hyaluronic acid44 2411.0CXCL2, ITGB2, TGFB2, SPP1
19ionomycin449.9IL12RB1, ITGB2, TNFRSF9, CTLA4, CD274
20calcitriol44 59 11 2412.8PPARA, TGFB2, EPO, SPP1
21prostaglandin449.8NPPA, TGFB2, AGTR1, CXCL2
22prostacyclin449.8NPPA, VASP, PPARA, AGTR1
23cgmp44 2810.8VASP, AGTR1, NPPA, LCN2
24actinomycin d449.8PPARA, SPP1, AGTR1, CIITA, TXN
25cholesterol44 28 11 2412.7ITGB2, PPARA, CTLA4, CIITA, AGTR1, SPP1
26wortmannin449.7ITGB2, CTLA4, CXCL2, SPP1, PSMC4
27oligonucleotide449.6CIITA, CXCL2, MYH6, SPP1, ITGB2, TGFB2
28genistein44 28 59 2 11 2414.6PPARA, PSMC4, ITGB2, AGTR1, SPP1, TGFB2
29cyclosporin a44 28 5911.6ITGB2, CTLA4, PSMC4, TXN, CIITA, TGFB2
30vitamin a44 11 2411.6TGFB2, TXN, LCN2
31testosterone44 59 11 2412.5TXN, NPPA, SPP1, PPARA, EPO, TGFB2
32ly294002449.5SPP1, EPO, ITGB2, CTLA4, PSMC4, CXCL2
33oxygen44 2410.5CXCL2, MYH6, CIITA, TXN, EPO, PSMC4
34arginine449.5NPPA, TXN, ITGB2, AGTR1, MYH6, SPP1
35fibrinogen449.5AGTR1, LCN2, CXCL2, ITGB2, VASP, SPP1
36cisplatin44 49 59 1112.4PPARA, TXN, SPP1, EPO, AGTR1
37lactate449.4ITGB2, EPO, TXN, CXCL2, SPP1
38vitamin d449.3SPP1, PPARA, TXN, TGFB2, EPO, AGTR1
39phosphatidylinositol449.3PSMC4, ITGB2, TGFB2, SPP1, EPO, AGTR1
40superoxide44 2410.2SPP1, LCN2, AGTR1, TXN
41alanine449.2SPP1, PSMC4, TXN, AGTR1, PPARA, ITGB2
42dexamethasone44 49 28 1112.1SPP1, TGFB2, CXCL2, CIITA, TNFRSF9, ITGB2
43lipid449.0PPARA, ITGB2, CIITA, AGTR1, CXCL2, MYH6
44cysteine449.0AGTR1, CIITA, ITGB2, PSMC4, TXN, TNFRSF9
45creatinine449.0TGFB2, EPO, AGTR1, SPP1, ITGB2, PPARA
46vegf448.7TGFB2, SPP1, CXCL2, TXN, NPPA, PSMC4
47serine448.7MYH6, PPARA, PSMC4, VASP, AGTR1, CIITA
48nitric oxide44 11 2410.5VASP, AGTR1, CD274, NPPA, PSMC4, TGFB2
49tyrosine448.0TGFB2, CIITA, ITGB2, PSMC4, SPP1, CTLA4
50calcium44 49 11 2411.0AGTR1, VASP, LCN2, TNFRSF9, NPPA, PSMC4

GO Terms for genes affiliated with Autoimmune Myocarditis

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16Gene Ontology
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Cellular components related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2ICOS, TNFRSF9, CTLA4, CD274, IL12RB1
2extracellular regionGO:0055768.7LCN2, ICOS, NPPA, EPO, CXCL2, SPP1
3extracellular spaceGO:0056158.5TGFB2, LCN2, TNFRSF9, TNFSF9, NPPA, EPO

Biological processes related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil chemotaxisGO:03059310.0ITGB2, SPP1, TGFB2
2protein homotrimerizationGO:0702079.9TNFRSF9, LCN2
3T cell costimulationGO:0312959.8CD274, CTLA4, ICOS
4immune responseGO:0069559.3CXCL2, CD274, CIITA, CTLA4, TNFSF9, ICOS
5cell-cell signalingGO:0072679.3TXN, TNFSF9, ITGB2, TGFB2
6apoptotic processGO:0069158.9LCN2, TNFRSF9, TNFSF9, PSMC4, ITGB2, EPO

Products for genes affiliated with Autoimmune Myocarditis

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  • Antibodies
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  • Antibodies

Sources for Autoimmune Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet