MCID: ATM022
MIFTS: 38

Autoimmune Myocarditis malady

Rare diseases, Cardiovascular diseases categories

Summaries for Autoimmune Myocarditis

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34MalaCards
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MalaCards: Autoimmune Myocarditis is related to myocarditis and thyroiditis. An important gene associated with Autoimmune Myocarditis is ICOS (inducible T-cell co-stimulator), and among its related pathways are B Cell Receptor Signaling Pathway and ICos-ICosL Pathway in T-Helper Cell. The compounds polyacrylamide and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells, heart and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Autoimmune Myocarditis

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

autoimmune myocarditis 44


Related Diseases for Autoimmune Myocarditis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.9MYH6, IL12RB1, CIITA
2thyroiditis30.1CIITA, CTLA4
3autoimmune thyroiditis30.1CTLA4, CIITA
4celiac disease30.1CIITA, CTLA4
5dilated cardiomyopathy10.4
6myocardial infarction10.2
7periodontitis10.2
8common variable immune deficiency10.1ICOS
9paracoccidioidomycosis10.1CTLA4
10rheumatic heart disease10.0
11acute myocarditis10.0
12hyperthyroidism10.0
13pneumonia10.0
14severe combined immunodeficiency10.0
15klebsiella10.0
16hypoxia10.0
17autoimmune hepatitis10.0CD274, CTLA4
18hepatitis b10.0CTLA4, CD274
19allergic asthma10.0CTLA4, IL12RB1
20hypothyroidism10.0MYH6, CTLA4
21atopic dermatitis10.0IL12RB1, CTLA4
22lupus nephritis10.0CIITA, CD274
23wegener's granulomatosis10.0CTLA4, CIITA
24vitiligo10.0CTLA4, CIITA
25primary biliary cirrhosis10.0CIITA, CTLA4
26encephalomyelitis10.0CTLA4, CIITA
27hepatitis c10.0CTLA4, CIITA
28ulcerative colitis10.0IL12RB1, CTLA4
29graves' disease10.0CTLA4, CIITA
30systemic scleroderma10.0CTLA4, CIITA
31type 1 diabetes mellitus10.0CTLA4, CIITA
32inflammatory bowel disease10.0CTLA4, CIITA
33multiple sclerosis10.0CD274, CIITA, CTLA4
34kidney cancer10.0CD274, CTLA4, CIITA
35viral infectious disease10.0CD274, CIITA, CTLA4
36immunodeficiency with hyper igm type 29.9CIITA, CD274
37asthma9.9IL12RB1, CTLA4, CIITA
38melanoma9.9CTLA4, CIITA, CD274
39systemic lupus erythematosus9.9IL12RB1, ICOS, CIITA, CTLA4
40rheumatoid arthritis9.9IL12RB1, CIITA, CD274, CTLA4
41hypersensitivity reaction type ii disease9.9IL12RB1, ICOS, CD274, CTLA4, CIITA

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Autoimmune Myocarditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Myocarditis

Search NIH Clinical Center for Autoimmune Myocarditis

Search CenterWatch for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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34MalaCards
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MalaCards organs/tissues related to Autoimmune Myocarditis:

34
T cells, Heart, Bone, Monocytes, B cells, Thymus, Thyroid

Animal Models for Autoimmune Myocarditis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CTLA4, CD274, IL12RB1, ICOS, CIITA
2MP:00053977.4CIITA, ICOS, IL12RB1, CD274, CTLA4
3MP:00053767.0CTLA4, CD274, IL12RB1, ICOS, MYH6, CIITA

Publications for Autoimmune Myocarditis

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53PubMed
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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 315)
idTitleAuthorsYear
1
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
2
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013
3
Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis. (22617620)
2012
4
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
5
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. (21928275)
2011
6
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
7
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
8
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
9
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. (18760191)
2008
10
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. (18403598)
2008
11
Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis. (18782607)
2008
12
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
13
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
14
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. (16698032)
2006
15
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
16
Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. (17060028)
2006
17
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
18
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
19
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. (16316965)
2005
20
Delayed contrast-enhanced magnetic resonance imaging for the detection of autoimmune myocarditis and long-term follow-up. (15881537)
2005
21
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
22
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
23
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
24
Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis. (15061762)
2004
25
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
26
Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. (14499870)
2003
27
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
28
Modern methods of treatment of autoimmune myocarditis. (12717549)
2003
29
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
30
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression. (12123771)
2002
31
Levels of MCP-1 and GM-CSF mRNA correlated with inflammatory cytokines mRNA levels in experimental autoimmune myocarditis in rats. (12071442)
2002
32
Contribution of the innate immune system to autoimmune myocarditis: a role for complement. (11477411)
2001
33
The transition from viral to autoimmune myocarditis. (11908774)
2001
34
Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis. (11438446)
2001
35
Role of cytokines in autoimmune myocarditis and cardiomyopathy. (11908773)
2001
36
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
37
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
38
Increases in cyclic AMP levels couple to H1 receptors in atria from autoimmune myocarditis mice. (8593244)
1995
39
A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells. (7633659)
1995
40
Anti-alpha beta T cell receptor antibody prevents the progression of experimental autoimmune myocarditis. (8004817)
1994
41
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
42
Effect of histamine in autoimmune myocarditis mice. (7806431)
1994
43
Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice. (18475540)
1993
44
Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. (8335952)
1993
45
Anitschkow cells in experimental autoimmune myocarditis. (1423981)
1992
46
Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis. (1639508)
1992
47
Beta-adrenergic cardiac antibody in autoimmune myocarditis. (2562378)
1989
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN, 56Reactome
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Compounds for genes affiliated with Autoimmune Myocarditis

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46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1polyacrylamide469.3CTLA4, MYH6
2glatiramer acetate46 1210.3CTLA4, CIITA
3enterotoxin469.2CTLA4, CIITA
4allergens469.2CIITA, CTLA4
5ionomycin469.2IL12RB1, CD274, CTLA4
6ganglioside469.1CTLA4, CIITA
7thyroxine46 259.9MYH6, CIITA
8dexamethasone46 52 30 1211.4CTLA4, CD274, IL12RB1, CIITA
9glucose468.2CIITA, MYH6, CTLA4

GO Terms for genes affiliated with Autoimmune Myocarditis

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17Gene Ontology
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Cellular components related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CTLA4, CD274, IL12RB1, ICOS

Biological processes related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell proliferationGO:0421309.2CTLA4, CD274
2cytokine-mediated signaling pathwayGO:0192219.1IL12RB1, CIITA
3T cell costimulationGO:0312959.0ICOS, CTLA4, CD274
4immune responseGO:0069558.3CTLA4, CD274, ICOS, CIITA

Products for genes affiliated with Autoimmune Myocarditis

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  • Antibodies
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Sources for Autoimmune Myocarditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet