MCID: ATM022
MIFTS: 34

Autoimmune Myocarditis malady

Rare diseases, Cardiovascular diseases, Muscle diseases categories

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 45


Classifications:



Summaries for Autoimmune Myocarditis

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MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and cardiomyopathy. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon, Gamma), and among its related pathways are MSP-RON Signaling and Cellular Transformation by HTLV1. Affiliated tissues include t cells, heart and monocytes, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis11.3
2cardiomyopathy10.6
3dilated cardiomyopathy10.5
4myocardial infarction10.2
5periodontitis10.2
6stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features10.2IFNG, TNF
7best1 retinopathy10.2IFNG, TNF
8scleroderma10.2IFNG, TNF
9opisthorchiasis10.2IFNG, TNF
10testicular leukemia10.2IFNG, TNF
11pneumonic tularemia10.2IFNG, TNF
12echinostomiasis10.2IFNG, TNF
13microsporidiosis10.2IFNG, TNF
14polycythemia10.2IFNG, TNF
15pulmonary valve agenesis - fallot's tetralogy - absence of ductus arteriosus10.2IFNG, TNF
16benign lymphoepithelial lesion of salivary gland10.2IFNG, TNF
17neonatal thyrotoxicosis10.2IFNG, TNF
18colitis10.2IFNG, TNF
19sternum cancer10.2IFNG, TNF
20cytoplasmic body myopathy10.2IFNG, TNF
21hemorrhagic proctocolitis10.2IFNG, TNF
22fibrogenesis imperfecta ossium10.2IFNG, TNF
23cutis laxa10.2IFNG, TNF
24lip cancer10.2IFNG, TNF
25early-onset, autosomal dominant alzheimer disease10.2IFNG, TNF
26hemolytic anemia10.2IFNG, TNF
27childhood disintegrative disease10.2IFNG, TNF
28powassan encephalitis10.2IFNG, TNF
29epiphora due to insufficient drainage10.2IFNG, TNF
30female reproductive organ cancer10.2IFNG, TNF
31rasmussen johnsen thomsen syndrome10.2IFNG, TNF
32dawson disease10.2IFNG, TNF
33alopecia universalis10.2IFNG, TNF
34eye accommodation disease10.2IFNG, TNF
35breast fibroadenosis10.2IFNG, TNF
36acute leukemia of ambiguous lineage10.2IFNG, TNF
37soft tissue sarcoma childhood10.2IFNG, TNF
38congenital heart disease10.2IFNG, TNF
39baritosis10.2IFNG, TNF
40herpangina10.2IFNG, TNF
41blastomycosis10.2IFNG, TNF
42ectropion10.2IFNG, TNF
43hemorrhoid10.2IFNG, TNF
44pneumoconiosis10.2IFNG, TNF
45spotted fever10.2IFNG, TNF
46cd3delta deficiency10.2IFNG, TNF
47integrative agnosia10.2IFNG, TNF
48lumbar plexus neoplasm10.2IFNG, TNF
49mesenteric vascular occlusion10.2IFNG, TNF
50bubonic plague10.1IFNG, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Infliximabapproved327170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
2
Certolizumab pegolapproved109428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
Cimzia
D03441
3
Adalimumabapproved411331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
4TNFR-Fc fusion protein367

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Inflammation in Systemic Lupus ErythematosusRecruitingNCT01761422
2RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

33
T cells, Heart, Monocytes, Bone, B cells, Thyroid, Thymus

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9ICOS, IFNG, PPARG, TNF
2MP:00053708.7IFNG, PPARG, SPP1, TNF
3MP:00053698.7IFNG, PPARG, SPP1, TNF
4MP:00053678.4AGTR1, IFNG, PPARG, SPP1
5MP:00020067.9ICOS, IFNG, PPARG, SPP1, TNF
6MP:00053977.9ICOS, IFNG, PPARG, SPP1, TNF
7MP:00053857.8AGTR1, IFNG, PPARG, SPP1, TNF
8MP:00053767.0AGTR1, ICOS, IFNG, PPARG, SPP1, TNF
9MP:00053876.8AGTR1, ICOS, IFNG, PPARG, SPP1, TNF

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 333)
idTitleAuthorsYear
1
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
2
Localization of CD8 T cell epitope within cardiac myosin heavy chain-I+334-352 that induces autoimmune myocarditis in A/J mice. (26422020)
2015
3
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. (25297507)
2014
4
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
5
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013
6
Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis. (22617620)
2012
7
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
8
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
9
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
10
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
11
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. (18760191)
2008
12
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. (18403598)
2008
13
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
14
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
15
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. (16698032)
2006
16
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
17
Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. (17060028)
2006
18
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
19
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
20
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. (16316965)
2005
21
Delayed contrast-enhanced magnetic resonance imaging for the detection of autoimmune myocarditis and long-term follow-up. (15881537)
2005
22
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
23
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
24
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
25
Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis. (15061762)
2004
26
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
27
Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. (14499870)
2003
28
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
29
Modern methods of treatment of autoimmune myocarditis. (12717549)
2003
30
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
31
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression. (12123771)
2002
32
Levels of MCP-1 and GM-CSF mRNA correlated with inflammatory cytokines mRNA levels in experimental autoimmune myocarditis in rats. (12071442)
2002
33
Contribution of the innate immune system to autoimmune myocarditis: a role for complement. (11477411)
2001
34
The transition from viral to autoimmune myocarditis. (11908774)
2001
35
Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis. (11438446)
2001
36
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
37
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
38
Increases in cyclic AMP levels couple to H1 receptors in atria from autoimmune myocarditis mice. (8593244)
1995
39
A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells. (7633659)
1995
40
Anti-alpha beta T cell receptor antibody prevents the progression of experimental autoimmune myocarditis. (8004817)
1994
41
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
42
Effect of histamine in autoimmune myocarditis mice. (7806431)
1994
43
Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice. (18475540)
1993
44
Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. (8335952)
1993
45
Anitschkow cells in experimental autoimmune myocarditis. (1423981)
1992
46
Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis. (1639508)
1992
47
Beta-adrenergic cardiac antibody in autoimmune myocarditis. (2562378)
1989
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNG, TNF
2
Show member pathways
9.5IFNG, TNF
39.5IFNG, TNF
4
Show member pathways
9.5IFNG, TNF
5
Show member pathways
9.5IFNG, TNF
69.5IFNG, TNF
7
Show member pathways
9.5IFNG, TNF
89.5IFNG, TNF
99.5IFNG, TNF
109.5PPARG, TNF
11
Show member pathways
9.1IFNG, PPARG, TNF
129.1IFNG, PPARG, TNF
13
B cell receptor signaling pathway (KEGG)
Show member pathways
9.0IFNG, PPARG, TNF
148.9IFNG, SPP1, TNF
158.9IFNG, SPP1, TNF
16
Show member pathways
8.7AGTR1, IFNG, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0ICOS, IFNG, TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:004508010.1IFNG, TNF
4positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IFNG, TNF
5protein import into nucleus, translocationGO:000006010.1IFNG, TNF
6extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
7humoral immune responseGO:000695910.0IFNG, TNF
8negative regulation of smooth muscle cell proliferationGO:004866210.0IFNG, PPARG
9negative regulation of growth of symbiont in hostGO:00441309.9IFNG, TNF
10positive regulation of osteoclast differentiationGO:00456729.8IFNG, TNF
11cellular response to organic cyclic compoundGO:00714079.6PPARG, TNF
12neutrophil chemotaxisGO:00305939.6IFNG, SPP1
13positive regulation of cell adhesionGO:00457859.5IFNG, TNF
14positive regulation of nitric oxide biosynthetic processGO:00454299.5IFNG, TNF
15immune responseGO:00069558.9ICOS, IFNG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.9IFNG, SPP1, TNF

Sources for Autoimmune Myocarditis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet