MCID: ATM022
MIFTS: 39

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 46

Classifications:



Summaries for Autoimmune Myocarditis

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NIH Rare Diseases:46 Autoimmune myocarditis is an autoimmune disease that affects the heart. the condition is characterized by inflammation of the heart muscle (myocardium). some people with autoimmune myocarditis have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. the exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. treatment is based on the signs and symptoms present in each person. in some cases, medications that suppress the immune system may be recommended. last updated: 2/23/2016

MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and panner disease. An important gene associated with Autoimmune Myocarditis is TNF (Tumor Necrosis Factor), and among its related pathways are Malaria and MSP-RON Signaling. Affiliated tissues include heart, t cells and bone, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis11.0
2panner disease10.5IFNG, TNF
3baetz-greenwalt syndrome10.5IFNG, TNF
4graft-versus-host disease, protection against10.5IFNG, TNF
5primary systemic mycosis10.5IFNG, TNF
6gonococcal synovitis10.5IFNG, TNF
7addison's disease10.5IFNG, TNF
8pasteurellosis10.5IFNG, TNF
9lymphocytic colitis10.5IFNG, TNF
10primary orthostatic tremor10.5IFNG, TNF
11amyotrophic lateral sclerosis type 410.5IFNG, TNF
12steatorrhea10.5IFNG, TNF
13hernia of ovary and fallopian tube10.5IFNG, TNF
14lipodermatosclerosis10.5IFNG, TNF
15stampe sorensen syndrome10.5IFNG, TNF
16meninges hemangiopericytoma10.5IFNG, TNF
17orbital lymphangioma10.5IFNG, TNF
18pseudoretinitis pigmentosa10.5IFNG, TNF
19potter's syndrome10.5IFNG, TNF
20pneumonic tularemia10.5IFNG, TNF
21renal cell carcinoma 410.5IFNG, TNF
22sensorineural hearing loss10.5IFNG, TNF
23scn8a encephalopathy10.5IFNG, TNF
24atrichia with papular lesions10.5IFNG, TNF
25psychologic dyspareunia10.5IFNG, TNF
26mastocytosis cutaneous with short stature conductive hearing loss and microtia10.5IFNG, TNF
27hemophagocytic lymphohistiocytosis10.5IFNG, TNF
28bolivian hemorrhagic fever10.5IFNG, TNF
29leukostasis10.5IFNG, TNF
30malignant histiocytosis10.5IFNG, TNF
31fibrous histiocytoma10.5IFNG, TNF
32dementia - subcortical10.5IFNG, TNF
33hypospadias10.5IFNG, TNF
34oesophagostomiasis10.5IFNG, TNF
35bartonellosis10.5IFNG, TNF
36binocular vision disease10.5IFNG, TNF
37lacrimal system cancer10.5IFNG, TNF
38gastric dilatation10.5IFNG, TNF
39bile duct signet ring cell carcinoma10.5IFNG, TNF
40louping ill10.5IFNG, TNF
41ehlers-danlos syndrome, musculocontractural type10.5IFNG, TNF
42chronic conjunctivitis10.5IFNG, TNF
43orbital periostitis10.5IFNG, TNF
44corneal intraepithelial neoplasm10.5IFNG, TNF
45reproductive system disease10.5IFNG, TNF
46subendocardial infarction acute myocardial infarction10.5IFNG, TNF
47common cold10.5IFNG, TNF
48esophagus melanoma10.5IFNG, TNF
49sarcoid meningitis10.5IFNG, TNF
50cutaneous porphyria10.5IFNG, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
infliximab364170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
2
Etanercept391185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
3
Certolizumab pegol119428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
4
adalimumab466331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) InfectionNot yet recruitingNCT02787382Phase 3
2Myocardial Inflammation in Systemic Lupus ErythematosusRecruitingNCT01761422
3RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

34
Heart, T cells, Bone, Monocytes, B cells, Lung, Thymus

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7IFNG, PPARG, SPP1, TNF
2MP:00030128.7CD274, IFNG, PPARG, TNF
3MP:00020068.5IFNG, PPARG, SPP1, TNF
4MP:00107718.1CD274, IFNG, PPARG, SPP1, TNF
5MP:00053678.1IFNG, NPPA, PPARG, SPP1
6MP:00053698.0IFNG, NPPA, PPARG, SPP1, TNF
7MP:00053857.7IFNG, NPPA, PPARG, SPP1, TNF
8MP:00053907.6CD274, IFNG, PPARG, SPP1, TNF
9MP:00053977.3CD274, IFNG, NPPA, PPARG, SPP1, TNF
10MP:00053766.8CD274, IFNG, NPPA, PPARG, SPP1, TNF

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Recent advances in the management of autoimmune myocarditis: insights from animal studies. (26696255)
2016
2
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. (27342875)
2016
3
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. (26621778)
2016
4
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. (27501378)
2016
5
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. (27440853)
2016
6
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
7
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. (26768489)
2015
8
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. (24447632)
2014
9
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease. (25191648)
2014
10
Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5. (25431156)
2014
11
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse. (24998332)
2014
12
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013
13
The periodontal pathogen aggregatibacter actinomycetemcomitans affects experimental autoimmune myocarditis in mice. (24309453)
2013
14
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
15
Correlation of left ventricular wall thickness, heart mass, serological parameters and late gadolinium enhancement in cardiovascular magnetic resonance imaging of myocardial inflammation in an experimental animal model of autoimmune myocarditis. (22327939)
2012
16
Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis. (23099153)
2012
17
Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. (21927577)
2011
18
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
19
Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis. (18608177)
2009
20
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
21
CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. (18250481)
2008
22
Genetic complexity of autoimmune myocarditis. (18190873)
2008
23
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
24
Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides. (17235437)
2007
25
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
26
Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. (17060028)
2006
27
A cyclooxygenase-2 inhibitor alters Th1/Th2 cytokine balance and suppresses autoimmune myocarditis in rats. (16499924)
2006
28
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
29
Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells. (15972947)
2005
30
Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. (15698832)
2005
31
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
32
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
33
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
34
Monomethoxypolyethylene glycol-modified cardiac myosin treatment blocks the active and passive induction of experimental autoimmune myocarditis. (14745151)
2004
35
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
36
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
37
Time course of gene expression in rat experimental autoimmune myocarditis. (12444915)
2002
38
cis Element decoy against nuclear factor-kappaB attenuates development of experimental autoimmune myocarditis in rats. (11701617)
2001
39
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. (11748115)
2001
40
Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation. (11535562)
2001
41
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
42
Experimental autoimmune myocarditis and its pathomechanism. (10904852)
2000
43
Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. (9008468)
1997
44
Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity. (7869033)
1995
45
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
46
Cardiac muscle cell damage through autoimmune mechanism--can cardiac proteins provoke autoimmune myocarditis? (1749072)
1991
47
Muscarinic cholinergic antibody in experimental autoimmune myocarditis regulates cardiac function. (2175437)
1990
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.2CD274, IFNG, TNF
2extracellular spaceGO:00056158.3IFNG, NPPA, SPP1, TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
4positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
5humoral immune responseGO:000695910.1IFNG, TNF
6protein import into nucleus, translocationGO:000006010.1IFNG, TNF
7extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
8regulation of insulin secretionGO:005079610.0IFNG, TNF
9positive regulation of osteoclast differentiationGO:004567210.0IFNG, TNF
10negative regulation of growth of symbiont in hostGO:004413010.0IFNG, TNF
11positive regulation of cell adhesionGO:004578510.0IFNG, TNF
12negative regulation of smooth muscle cell proliferationGO:00486629.9IFNG, PPARG
13regulation of blood pressureGO:00082179.6NPPA, PPARG
14positive regulation of nitric oxide biosynthetic processGO:00454299.6IFNG, TNF
15positive regulation of T cell proliferationGO:00421029.1CD274, IFNG
16positive regulation of apoptotic processGO:00430659.1IFNG, PPARG, TNF
17response to organic substanceGO:00100338.8PPARG, SPP1, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.8IFNG, SPP1, TNF

Sources for Autoimmune Myocarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet