MCID: ATM022
MIFTS: 38

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 45

Classifications:



Summaries for Autoimmune Myocarditis

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NIH Rare Diseases:45 Autoimmune myocarditis is an autoimmune disease that affects the heart. the condition is characterized by inflammation of the heart muscle (myocardium). some people with autoimmune myocarditis have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. the exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. treatment is based on the signs and symptoms present in each person. in some cases, medications that suppress the immune system may be recommended. last updated: 2/23/2016

MalaCards based summary: Autoimmune Myocarditis is related to food allergy and motion sickness. An important gene associated with Autoimmune Myocarditis is TNF (Tumor Necrosis Factor), and among its related pathways are Downstream signaling in naive CD8+ T cells and TGF Beta Signaling Pathway. Affiliated tissues include heart, breast and t cells, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1food allergy30.3IFNG, TNF
2motion sickness30.1IFNG, TNF
3breast cancer10.3
4retinitis10.3
5leukemia10.3
6non-distal monosomy 10q10.3IFNG, TNF
7ethmoid sinus squamous cell carcinoma10.3IFNG, TNF
8parasitic ichthyosporea infectious disease10.3IFNG, TNF
9gonococcal bursitis10.3IFNG, TNF
10opisthorchiasis10.3IFNG, TNF
11collagenous colitis10.2IFNG, TNF
12atrichia with papular lesions10.2IFNG, TNF
13hypercementosis10.2IFNG, TNF
14early-onset, autosomal dominant alzheimer disease10.2IFNG, TNF
15soft tissue sarcoma childhood10.2IFNG, TNF
16hydronephrosis10.2IFNG, TNF
17argentine hemorrhagic fever10.2IFNG, TNF
18b cell deficiency10.2IFNG, TNF
19cytoplasmic body myopathy10.2IFNG, TNF
20hemorrhagic proctocolitis10.2IFNG, TNF
21dancing eyes-dancing feet syndrome10.2IFNG, TNF
22hemolytic anemia10.2IFNG, TNF
23cryptosporidiosis10.2IFNG, TNF
24central nervous system melanocytic neoplasm10.2IFNG, TNF
25proliferative fasciitis10.2IFNG, TNF
26soft palate cancer10.2IFNG, TNF
27chronic tic disorder10.2IFNG, TNF
28peripheral retinal degeneration10.2IFNG, TNF
29hepatoid adenocarcinoma10.2IFNG, TNF
30cervix melanoma10.2IFNG, TNF
31trench fever10.2IFNG, TNF
32acute leukemia of ambiguous lineage10.2IFNG, TNF
33meige syndrome10.2IFNG, TNF
34vagus nerve neoplasm10.2IFNG, TNF
35cryoglobulinemia10.2IFNG, TNF
36byssinosis10.2IFNG, TNF
37tracheal stenosis10.2IFNG, TNF
38tuberculoid leprosy10.2IFNG, TNF
39tethered spinal cord syndrome10.2IFNG, TNF
40adenocarcinoma10.2
41blastomycosis10.2IFNG, TNF
42acute orbital inflammation10.2IFNG, TNF
43leech infestation10.2IFNG, TNF
44colon sarcoma10.2IFNG, TNF
45conventional malignant hemangiopericytoma10.2IFNG, TNF
46porphyria10.2IFNG, TNF
47reflex sympathetic dystrophy10.2IFNG, TNF
48renal oncocytoma10.2IFNG, TNF
49miliary tuberculosis10.2IFNG, TNF
50acute gonococcal epididymo-orchitis10.2IFNG, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Infliximabapproved349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
2
Adalimumabapproved443331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
3
Etanerceptapproved, investigational383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
Certolizumab pegolapproved117428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
Cimzia
D03441
5Antirheumatic Agents8496
6Immunologic Factors18483
7Immunosuppressive Agents10422

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Inflammation in Systemic Lupus ErythematosusRecruitingNCT01761422
2RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

33
Heart, Breast, T cells, Lung, Thyroid, Endothelial, Testes

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6IFNG, PPARA, PPARG, TNF
2MP:00030128.1CD274, IFNG, PPARG, TNF
3MP:00053698.1IFNG, PPARA, PPARG, TNF
4MP:00107717.8CD274, IFNG, PPARA, PPARG, TNF
5MP:00053847.5CD274, IFNG, PPARA, PPARG, TNF
6MP:00053877.5CD274, IFNG, PPARA, PPARG, TNF

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 338)
idTitleAuthorsYear
1
The feasibility of progressive resistance training in women with polycystic ovary syndrome: a pilot randomized controlled trial. (27175282)
2016
2
Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1. (25738863)
2015
3
mRNA TLR2 AND TLR4 EXPRESSION IN THE ENDOMETRIUM TISSUE IN WOMEN WITH ENDOMETRIOSIS ASSOSIATED WITH INFERTILITY. (26177128)
2015
4
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. (26541605)
2015
5
Association Between Psoriasis and Asthma: A Population-Based Retrospective Cohort Analysis. (25385450)
2014
6
Resistance to inhibitors of cholinesterase (Ric)-8A and GI+i contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. (24466196)
2014
7
Effects of smoking on visual acuity of central serous chorioretinopathy patients. (23841829)
2013
8
Venous thromboembolism risk and erythropoiesis-stimulating agents for the treatment of cancer-associated anemia: a meta-analysis. (23959477)
2013
9
Self double-stranded (ds)DNA induces IL-1I^ production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies. (23315075)
2013
10
Sugammadex and general anaesthesia in a patient with Brugada syndrome. (23659415)
2013
11
A randomized controlled trial for the use of Thymus Honey in decreasing Salivary Gland Damage following Radioiodine Therapy for Thyroid cancer: research protocol. (24256334)
2013
12
Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction. (23846499)
2013
13
Motion and pain relief remain 23 years after manipulation under anesthesia for frozen shoulder. (22907476)
2013
14
MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7. (23435373)
2013
15
Flanking nucleotide specificity for DNA mismatch repair-deficient frameshifts within activin receptor 2 (ACVR2). (22001236)
2012
16
Cognitive decline as a consequence of essential hypertension. (21861834)
2011
17
Clinical presentation and treatment of atrial fibrillation in Wolff-Parkinson-White syndrome. (20207273)
2010
18
Prevalence and record of alcoholism among emergency department patients. (19142548)
2009
19
The core-aldehyde 9-oxononanoyl cholesterol increases the level of transforming growth factor beta1-specific receptors on promonocytic U937 cell membranes. (19302374)
2009
20
Expression of multidrug resistance-related protein (MRP-1), lung resistance-related protein (LRP) and topoisomerase-II (TOPO-II) in Wilms' tumor: immunohistochemical study using TMA methodology. (18795074)
2008
21
Proliferative diabetic retinopathy and hemovitreous: red flag for blindness. (18454250)
2008
22
X-ray repair cross-complementing group 4 (XRCC4) promoter -1394( *)T-related genotype, but not XRCC4 codon 247/intron 3 or xeroderma pigmentosum group D codon 312, 751/promoter -114, polymorphisms are correlated with higher susceptibility to myoma. (18177646)
2008
23
Autoimmune lymphoproliferative syndrome (ALPS): a rare cause of immune cytopenia. (18310796)
2008
24
Imatinib-induced Stevens-Johnson syndrome: recurrence after re-challenge with a lower dose. (17287945)
2007
25
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
2006
26
Morbus gaucher--a report of two cases]. (17252710)
2006
27
Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. (16815146)
2006
28
A post-partum hemolytic-uremic-like-syndrome in a patient with pre-eclampsia: description of a clinical case. (16427809)
2006
29
Changes in the RANK ligand/osteoprotegerin system are correlated to changes in bone mineral density in bisphosphonate-treated osteoporotic patients. (16435076)
2006
30
Extraordinarily high F-18 FDG uptake caused by a pleomorphic adenoma of the parotid gland. (16985375)
2006
31
Clinical presentation of McCune-Albright syndrome in males. (16789625)
2006
32
A Fontan completion through stage I bilateral pulmonary artery banding for hypoplastic left heart syndrome. (16256807)
2005
33
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. (15577914)
2004
34
Ovarian and uterine findings in pelvic sonography: comparison between prepubertal girls, girls with isolated thelarche, and girls with central precocious puberty. (12418765)
2002
35
Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformation. (11967310)
2002
36
Establishment of a consistent L929 bioassay system for TNF-alpha quantitation to evaluate the effect of lipopolysaccharide, phytomitogens and cytodifferentiation agents on cytotoxicity of TNF-alpha secreted by adherent human mononuclear cells. (11577996)
2001
37
HIV-1 NL4-3, but not IIIB, inhibits JAK3/STAT5 activation in CD4(+) T cells. (11485409)
2001
38
High-density lipoprotein composition and paraoxonase activity in Type I diabetes. (11724654)
2001
39
Binding of six chimeric analogs of omega-conotoxin MVIIA and MVIIC to N- and P/Q-type calcium channels. (10694509)
2000
40
A compartmentalised model for the estimation of the cost of coccidiosis to the world's chicken production industry. (10576573)
1999
41
Crystal structure of the S-nitroso form of liganded human hemoglobin. (9843411)
1998
42
Study of 2-(2-hydroxy-3-isopropylaminopropoxy)-5-(propoxymethyl) acetophenone--a potential adrenoreceptor beta blocker affecting the function of myocardial mitochondria after administration of isoprenaline]. (9600145)
1997
43
Identification of two candidate tumor suppressor genes on chromosome 17p13.3. (8616839)
1996
44
The age of human mutation: genealogical and linkage disequilibrium analysis of the CLN5 mutation in the Finnish population. (8644710)
1996
45
Efficacy of drug regimen exceeds electrostimulation in treatment of avian muscular dystrophy. (7665393)
1995
46
N-acetyl-beta-glucosaminidase (beta-NAG) in urine: a parameter for early detection of diabetogenic nephropathy in childhood]. (8367178)
1993
47
Thymidine phosphorylase activity and its relationship to trimethoprim in initial strains and thymidine-, thymine-dependent and trimethoprim-resistant mutants of plague microbe]. (1530352)
1992
48
Human glioblastoma cells release interleukin 6 in vivo and in vitro. (2208133)
1990
49
Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism, and multiple congenital anomalies. (3024486)
1986
50
Hemodynamic effects of trinitroglycerin in aortic and mitral valve disease. (6769780)
1980

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5IFNG, TNF
29.5IFNG, TNF
39.5IFNG, TNF
49.5IFNG, TNF
59.5IFNG, TNF
6
Show member pathways
9.5IFNG, TNF
79.5IFNG, TNF
89.5IFNG, TNF
99.5IFNG, TNF
109.5IFNG, TNF
119.5IFNG, TNF
129.5IFNG, TNF
13
Show member pathways
9.5IFNG, TNF
14
Show member pathways
9.5IFNG, TNF
159.5PPARA, TNF
169.4PPARG, TNF
17
Show member pathways
9.3PPARA, PPARG
18
Show member pathways
9.3PPARA, PPARG
199.3PPARA, PPARG
209.2CD274, TNF
21
Show member pathways
8.9IFNG, PPARG, TNF
228.9IFNG, PPARG, TNF
238.9PPARA, PPARG, TNF
24
Show member pathways
8.9PPARA, PPARG, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
4negative regulation of growth of symbiont in hostGO:004413010.1IFNG, TNF
5positive regulation of fatty acid oxidationGO:004632110.0PPARA, PPARG
6negative regulation of cholesterol storageGO:001088710.0PPARA, PPARG
7protein import into nucleus, translocationGO:000006010.0IFNG, TNF
8response to virusGO:000961510.0IFNG, TNF
9positive regulation of cell adhesionGO:00457859.9IFNG, TNF
10positive regulation of osteoclast differentiationGO:00456729.9IFNG, TNF
11negative regulation of receptor biosynthetic processGO:00108719.9PPARA, PPARG
12regulation of insulin secretionGO:00507969.9IFNG, TNF
13regulation of circadian rhythmGO:00427529.8PPARA, PPARG
14negative regulation of smooth muscle cell proliferationGO:00486629.8IFNG, PPARG
15extrinsic apoptotic signaling pathwayGO:00971919.8IFNG, TNF
16negative regulation of gene expressionGO:00106299.7IFNG, TNF
17positive regulation of apoptotic processGO:00430659.7PPARG, TNF
18lipid metabolic processGO:00066299.7PPARA, PPARG
19cellular response to lipopolysaccharideGO:00712229.6IFNG, TNF
20activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4PPARG, TNF
21defense response to bacteriumGO:00427429.4IFNG, TNF
22regulation of transcription, DNA-templatedGO:00063559.0IFNG, PPARA, PPARG
23immune responseGO:00069558.8CD274, IFNG, TNF
24positive regulation of transcription, DNA-templatedGO:00458938.8IFNG, PPARA, PPARG, TNF
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.4IFNG, PPARA, PPARG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.3PPARA, PPARG

Sources for Autoimmune Myocarditis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet