MCID: ATM022
MIFTS: 39

Autoimmune Myocarditis malady

Rare diseases, Cardiovascular diseases, Muscle diseases categories
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Summaries for Autoimmune Myocarditis

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MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and thyroiditis. An important gene associated with Autoimmune Myocarditis is ICOS (inducible T-cell co-stimulator), and among its related pathways are B Cell Receptor Signaling Pathway and ICos-ICosL Pathway in T-Helper Cell. The compounds polyacrylamide and glatiramer acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells, heart and bone, and related mouse phenotypes are immune system and hematopoietic system.

Aliases & Classifications for Autoimmune Myocarditis

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Autoimmune Myocarditis, Aliases & Descriptions:

Name: Autoimmune Myocarditis 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Muscle diseases


Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 39)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis31.7MYH6, IL12RB1, CIITA
2thyroiditis30.2CIITA, CTLA4
3autoimmune thyroiditis30.1CTLA4, CIITA
4celiac disease30.1CIITA, CTLA4
5dilated cardiomyopathy10.5
6common variable immunodeficiency10.4ICOS
7paracoccidioidomycosis10.4CTLA4
8myocardial infarction10.2
9periodontitis10.2
10autoimmune hepatitis10.2CD274, CTLA4
11hepatitis b10.2CTLA4, CD274
12allergic asthma10.1CTLA4, IL12RB1
13hypothyroidism10.1MYH6, CTLA4
14severe combined immunodeficiency10.1
15acute myocarditis10.1
16hyperthyroidism10.1
17pneumonia10.1
18klebsiella10.1
19hypoxia10.1
20atopic dermatitis10.1IL12RB1, CTLA4
21lupus nephritis10.0CIITA, CD274
22wegener's granulomatosis10.0CTLA4, CIITA
23vitiligo10.0CTLA4, CIITA
24primary biliary cirrhosis10.0CIITA, CTLA4
25hepatitis c10.0CTLA4, CIITA
26ulcerative colitis10.0IL12RB1, CTLA4
27graves' disease10.0CTLA4, CIITA
28systemic scleroderma9.9CTLA4, CIITA
29type 1 diabetes mellitus9.9CTLA4, CIITA
30inflammatory bowel disease9.9CTLA4, CIITA
31multiple sclerosis9.8CD274, CIITA, CTLA4
32kidney cancer9.8CD274, CTLA4, CIITA
33viral infectious disease9.8CD274, CIITA, CTLA4
34immunodeficiency with hyper igm type 29.8CIITA, CD274
35asthma9.8IL12RB1, CTLA4, CIITA
36melanoma9.7CTLA4, CIITA, CD274
37systemic lupus erythematosus9.6IL12RB1, ICOS, CIITA, CTLA4
38rheumatoid arthritis9.6IL12RB1, CIITA, CD274, CTLA4
39hypersensitivity reaction type ii disease9.4IL12RB1, ICOS, CD274, CTLA4, CIITA

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Myocarditis

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

32
T cells, Heart, Bone, Monocytes, B cells, Thymus, Thyroid

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.7CIITA, ICOS, CD274, CTLA4, IL12RB1
2MP:00053977.4ICOS, IL12RB1, CD274, CTLA4, CIITA
3MP:00053767.0CTLA4, CIITA, MYH6, ICOS, IL12RB1, CD274

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 327)
idTitleAuthorsYear
1
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. (25297507)
2014
2
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
3
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013
4
Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis. (22617620)
2012
5
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
6
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. (21928275)
2011
7
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
8
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
9
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
10
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. (18760191)
2008
11
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. (18403598)
2008
12
Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis. (18782607)
2008
13
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
14
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
15
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. (16698032)
2006
16
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
17
Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. (17060028)
2006
18
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
19
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
20
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. (16316965)
2005
21
Delayed contrast-enhanced magnetic resonance imaging for the detection of autoimmune myocarditis and long-term follow-up. (15881537)
2005
22
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
23
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
24
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
25
Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis. (15061762)
2004
26
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
27
Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. (14499870)
2003
28
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
29
Modern methods of treatment of autoimmune myocarditis. (12717549)
2003
30
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
31
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression. (12123771)
2002
32
Levels of MCP-1 and GM-CSF mRNA correlated with inflammatory cytokines mRNA levels in experimental autoimmune myocarditis in rats. (12071442)
2002
33
Contribution of the innate immune system to autoimmune myocarditis: a role for complement. (11477411)
2001
34
The transition from viral to autoimmune myocarditis. (11908774)
2001
35
Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis. (11438446)
2001
36
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
37
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
38
Increases in cyclic AMP levels couple to H1 receptors in atria from autoimmune myocarditis mice. (8593244)
1995
39
A histological study on experimental autoimmune myocarditis with special reference to initiation of the disease and cardiac dendritic cells. (7633659)
1995
40
Anti-alpha beta T cell receptor antibody prevents the progression of experimental autoimmune myocarditis. (8004817)
1994
41
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
42
Effect of histamine in autoimmune myocarditis mice. (7806431)
1994
43
Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice. (18475540)
1993
44
Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. (8335952)
1993
45
Anitschkow cells in experimental autoimmune myocarditis. (1423981)
1992
46
Adoptively transferred anti-idiotype pulsed B cells mediate autoimmune myocarditis. (1639508)
1992
47
Beta-adrenergic cardiac antibody in autoimmune myocarditis. (2562378)
1989
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Expression patterns in normal tissues for genes affiliated with Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Compounds for genes affiliated with Autoimmune Myocarditis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 28IUPHAR
See all sources

Compounds related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1polyacrylamide449.3CTLA4, MYH6
2glatiramer acetate44 1110.3CTLA4, CIITA
3enterotoxin449.2CTLA4, CIITA
4allergens449.2CIITA, CTLA4
5ionomycin449.2IL12RB1, CD274, CTLA4
6ganglioside449.1CTLA4, CIITA
7thyroxine44 249.9MYH6, CIITA
8dexamethasone44 50 28 1111.4CTLA4, CD274, IL12RB1, CIITA
9glucose448.2CIITA, MYH6, CTLA4

GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.6CTLA4, CD274, IL12RB1, ICOS

Biological processes related to Autoimmune Myocarditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of T cell proliferationGO:0421309.2CTLA4, CD274
2cytokine-mediated signaling pathwayGO:0192219.1IL12RB1, CIITA
3T cell costimulationGO:0312959.0ICOS, CTLA4, CD274
4immune responseGO:0069558.3CTLA4, CD274, ICOS, CIITA

Products for genes affiliated with Autoimmune Myocarditis

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  • Antibodies
  • Proteins
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Sources for Autoimmune Myocarditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet