MCID: ATM022
MIFTS: 42

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 48

Classifications:



Summaries for Autoimmune Myocarditis

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NIH Rare Diseases:48 Autoimmune myocarditis is an autoimmune disease that affects the heart. the condition is characterized by inflammation of the heart muscle (myocardium). some people with autoimmune myocarditis have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. the exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. treatment is based on the signs and symptoms present in each person. in some cases, medications that suppress the immune system may be recommended. last updated: 2/23/2016

MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and tubular renal disease-cardiomyopathy syndrome. An important gene associated with Autoimmune Myocarditis is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways are Transcription factor regulation in adipogenesis and Interleukin-10 signaling. Affiliated tissues include heart, t cells and bone, and related mouse phenotypes are craniofacial and renal/urinary system.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis10.9
2tubular renal disease-cardiomyopathy syndrome10.2IL4, TNF
3lagophthalmos10.1IL4, TNF
4conidiobolomycosis10.1IL4, TNF
5vestibule of mouth cancer10.1IL4, TNF
6cardiomyopathy10.1
7intracranial arteriosclerosis10.1SPP1, TNF
8congenital hypothyroidism10.1IL4, TNF
9mikulicz disease10.1IL4, TNF
10myoglobinuria recurrent10.1IFNG, IL4
11asymptomatic neurosyphilis10.1IFNG, IL4
12gonococcal endophthalmia10.1IL4, TNF
13stocco dos santos syndrome10.1IFNG, TNF
14distal trisomy 14q10.1IFNG, TNF
15tungiasis10.1IFNG, IL4
16autosomal recessive type iv ehlers-danlos syndrome10.1IL4, TNF
17crustacean allergy10.1IFNG, IL4
18leydig cell hypoplasia10.1SPP1, TNF
19aniseikonia10.1IFNG, TNF
20centronuclear myopathy 510.1IFNG, IL4
21esophagus lymphoma10.1IFNG, TNF
22acute gonococcal prostatitis10.1IFNG, IL4
23spastic paraplegia 110.1IFNG, TNF
24parkinson disease 1110.1IFNG, TNF
25myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr110.1IFNG, TNF
26cutaneous fibrous histiocytoma10.1IFNG, IL4
27ovarian papillary cystadenoma10.1IFNG, IL4
28isolated klippel-feil syndrome10.1IFNG, IL4
29glucose intolerance10.1IFNG, TNF
30senile reticular retinal degeneration10.1IFNG, TNF
31conduct disorder10.1IFNG, TNF
32pancreatic signet ring cell adenocarcinoma10.1IFNG, TNF
33hyperinsulinism due to glutamodehydrogenase deficiency10.1IFNG, IL4
34pulpitis10.1IFNG, TNF
35hypertropia10.1IFNG, TNF
36immune-complex glomerulonephritis10.1IFNG, IL4
37hereditary alpha tryptasemia syndrome10.1IFNG, TNF
38rickettsialpox10.1IFNG, TNF
39erb-duchenne and dejerine-klumpke palsies10.1IFNG, TNF
40benign deep fibrous histiocytoma10.1IFNG, TNF
41plummer's disease10.1IFNG, TNF
42peripheral artery disease10.0IL4, TNF
43hydrophthalmos10.0IFNG, IL4
44steatitis10.0IL2, TNF
45loiasis10.0IFNG, IL4
46sarcoma10.0IL2, IL4
47vulvar vestibulitis syndrome10.0IL2, IL4
48disease of mental health10.0IFNG, TNF
49dilated cardiomyopathy10.0
50thymic neuroendocrine carcinoma10.0IL2, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

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MGI Mouse Phenotypes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

41 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9IFNG, IL4, SPP1, TNF
2MP:00053678.8IFNG, IL4, PPARG, SPP1
3MP:00053908.2IFNG, IL4, PPARG, SPP1, TNF
4MP:00020068.1IFNG, IL2, PPARG, SPP1, TNF
5MP:00107717.9IFNG, IL4, PPARG, SPP1, TNF
6MP:00053917.9IFNG, IL2, IL4, PPARG, TNF
7MP:00053857.8IFNG, IL2, PPARG, SPP1, TNF
8MP:00053797.6IFNG, IL2, IL4, PPARG, TNF
9MP:00053887.6IFNG, IL2, IL4, SPP1, TNF
10MP:00030127.6IFNG, IL2, IL4, PPARG, TNF
11MP:00053897.5IFNG, IL2, IL4, PPARG, SPP1, TNF
12MP:00053767.4IFNG, IL2, IL4, PPARG, SPP1, TNF
13MP:00107687.4IFNG, IL2, IL4, PPARG, SPP1, TNF
14MP:00053847.3IFNG, IL2, IL4, PPARG, SPP1, TNF
15MP:00053787.3IFNG, IL2, IL4, PPARG, SPP1, TNF
16MP:00053877.3IFNG, IL2, IL4, PPARG, SPP1, TNF
17MP:00053977.0IFNG, IL2, IL4, PPARG, SPP1, TNF
18MP:00053706.8IFNG, IL2, IL4, PPARG, SPP1, TNF

Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
InfliximabapprovedPhase 4392170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
2
MethotrexateapprovedPhase 415511959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
3
Etanerceptapproved, investigationalPhase 4403185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
Certolizumab pegolapprovedPhase 4127428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
5
AdalimumabapprovedPhase 4494331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
6Antirheumatic AgentsPhase 410956

Interventional clinical trials:

idNameStatusNCT IDPhase
1RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768Phase 4
2Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) InfectionNot yet recruitingNCT02787382Phase 3
3Myocardial Inflammation in Systemic Lupus ErythematosusUnknown statusNCT01761422
4Cardiac and Laboratory Findings in Patients With Systemic Lupus ErythematosusNot yet recruitingNCT03179046

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Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

36
Heart, T cells, Bone, Monocytes, B cells, Lung, Thymus

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. (27922195)
2017
2
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. (27099262)
2016
3
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. (27440853)
2016
4
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. (27615269)
2016
5
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. (26696258)
2016
6
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. (27342875)
2016
7
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. (27501378)
2016
8
Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice. (27818491)
2016
9
Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats. (26946470)
2016
10
Cacao polyphenols ameliorate autoimmune myocarditis in mice. (26657007)
2016
11
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. (27502060)
2016
12
Recent advances in the management of autoimmune myocarditis: insights from animal studies. (26696255)
2016
13
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. (26772776)
2016
14
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. (27288745)
2016
15
Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder. (27095924)
2016
16
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. (26899795)
2016
17
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. (26660726)
2016
18
Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM). (27501319)
2016
19
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. (26621778)
2016
20
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. (26658748)
2016
21
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. (27044832)
2016
22
Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. (27052830)
2016
23
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. (27390159)
2016
24
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. (27184135)
2016
25
Mouse Models of Autoimmune Diseases - Autoimmune Myocarditis. (25777763)
2015
26
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
27
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. (26475067)
2015
28
Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis. (25596465)
2015
29
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. (26768489)
2015
30
Anti-inflammatory Role of Obestatin in Autoimmune myocarditis. (26426263)
2015
31
A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice. (25768281)
2015
32
Intravital microscopy -A novel toolin characterizing congestive heart failurein experimental autoimmune myocarditis. (26484717)
2015
33
Localization of CD8 T cell epitope within cardiac myosin heavy chain-I+334-352 that induces autoimmune myocarditis in A/J mice. (26422020)
2015
34
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis. (24269624)
2014
35
Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease. (24732212)
2014
36
N-Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide. (25147347)
2014
37
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis. (24189626)
2014
38
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. (25297507)
2014
39
Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5. (25431156)
2014
40
Blocking the receptor for advanced glycation end product activation attenuates autoimmune myocarditis. (24599045)
2014
41
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease. (25191648)
2014
42
Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. (24205804)
2014
43
Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy. (25551279)
2014
44
Mortality and Morbidity in Different Immunization Protocols for Experimental Autoimmune Myocarditis in Rats. (24410878)
2014
45
Tenascin-C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation. (25376187)
2014
46
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse. (24998332)
2014
47
Experimental drugs for treatment of autoimmune myocarditis. (25146626)
2014
48
A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4(+) T and macrophage infiltration and NADPH oxidase 2/4 expression in mice. (24879505)
2014
49
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. (24447632)
2014
50
Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction. (21684025)
2013

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathwaysScoreTop Affiliating Genes
19.5PPARG, TNF
29.4IL4, TNF
39.3IFNG, TNF
49.3IFNG, TNF
5
Show member pathways
9.3IFNG, TNF
69.3IFNG, TNF
79.0IFNG, IL2
89.0IL4, SPP1, TNF
98.9IFNG, PPARG, TNF
10
Show member pathways
8.9IFNG, SPP1, TNF
118.9IFNG, SPP1, TNF
128.8IFNG, IL4, TNF
13
Show member pathways
8.8IFNG, IL4, TNF
14
Show member pathways
8.8IFNG, IL4, TNF
15
Show member pathways
8.8IFNG, IL4, TNF
168.7IL2, IL4, SPP1
178.6IL2, IL4, TNF
188.5IFNG, IL2, TNF
19
Show member pathways
8.5IFNG, IL2, TNF
20
Show member pathways
8.5IFNG, IL2, TNF
21
Show member pathways
8.5IFNG, IL2, TNF
22
Show member pathways
8.5IFNG, IL2, TNF
23
Show member pathways
8.5IFNG, IL2, TNF
248.5IFNG, IL2, TNF
258.5IFNG, IL2, TNF
268.5IFNG, IL2, IL4
27
Show member pathways
8.5IFNG, IL2, IL4
288.5IFNG, IL2, IL4
298.5IFNG, IL2, IL4
30
Show member pathways
8.5IFNG, IL2, IL4
318.5IFNG, IL2, IL4
32
Show member pathways
8.1IFNG, IL2, SPP1, TNF
33
Show member pathways
8.0IFNG, IL2, IL4, TNF
34
Show member pathways
8.0IFNG, IL2, IL4, TNF
35
Show member pathways
8.0IFNG, IL2, IL4, TNF
368.0IFNG, IL2, IL4, TNF
378.0IFNG, IL2, IL4, TNF
388.0IFNG, IL2, IL4, TNF
398.0IFNG, IL2, IL4, TNF
40
Show member pathways
8.0IFNG, IL2, IL4, TNF
41
Show member pathways
8.0IFNG, IL2, IL4, TNF
42
Show member pathways
8.0IFNG, IL2, IL4, TNF
43
Show member pathways
8.0IFNG, IL2, IL4, TNF
448.0IFNG, IL2, IL4, TNF
45
Show member pathways
8.0IFNG, IL2, IL4, TNF
46
Show member pathways
7.6IFNG, IL2, IL4, PPARG, TNF
47
Show member pathways
7.5IFNG, IL2, IL4, SPP1, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6IFNG, IL4, TNF
2extracellular regionGO:00055768.3IFNG, IL2, IL4, SPP1, TNF
3extracellular spaceGO:00056157.5IFNG, IL2, IL4, SPP1, TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of acute inflammatory responseGO:000267410.3IL4, PPARG
2negative regulation of smooth muscle cell proliferationGO:004866210.2IFNG, PPARG
3positive regulation of mononuclear cell migrationGO:007167710.2IL4, TNF
4extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
5defense response to protozoanGO:004283210.1IFNG, IL4
6humoral immune responseGO:000695910.1IFNG, TNF
7negative regulation of growth of symbiont in hostGO:004413010.1IFNG, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:006055910.1IFNG, TNF
9positive regulation of cell adhesionGO:004578510.1IFNG, TNF
10positive regulation of membrane protein ectodomain proteolysisGO:005104410.1IFNG, TNF
11positive regulation of nitric oxide biosynthetic processGO:004542910.1IFNG, TNF
12positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
13positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
14positive regulation of protein complex assemblyGO:003133410.1IFNG, TNF
15positive regulation of vitamin D biosynthetic processGO:006055710.0IFNG, TNF
16protein import into nucleus, translocationGO:000006010.0IFNG, TNF
17extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL2, IL4
18negative regulation of T-helper 17 cell differentiationGO:20003209.9IL2, IL4
19positive regulation of activated T cell proliferationGO:00421049.9IL2, IL4
20positive regulation of B cell proliferationGO:00308909.9IL2, IL4
21positive regulation of interferon-gamma productionGO:00327299.9IL2, TNF
22positive regulation of T cell differentiationGO:00455829.9IL2, IL4
23positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8IL2, IL4
24positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.8IL4, PPARG, TNF
25positive regulation of apoptotic processGO:00430659.7IFNG, PPARG, TNF
26positive regulation of chemokine biosynthetic processGO:00450809.6IFNG, IL4, TNF
27response to drugGO:00424939.4IFNG, IL4, PPARG
28positive regulation of isotype switching to IgG isotypesGO:00483049.3IFNG, IL2, IL4
29positive regulation of T cell proliferationGO:00421029.3IFNG, IL2, IL4
30negative regulation of transcription, DNA-templatedGO:00458929.2IFNG, IL4, PPARG, TNF
31positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.2IFNG, IL2, IL4
32response to organic substanceGO:00100339.1PPARG, SPP1, TNF
33immune responseGO:00069558.8IFNG, IL2, IL4, TNF
34positive regulation of protein phosphorylationGO:00019348.7IFNG, IL2, IL4, TNF
35positive regulation of transcription, DNA-templatedGO:00458938.6IFNG, IL4, PPARG, SPP1, TNF
36positive regulation of transcription from RNA polymerase II promoterGO:00459448.3IFNG, IL2, IL4, PPARG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051257.5IFNG, IL2, IL4, SPP1, TNF

Sources for Autoimmune Myocarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet