MCID: ATM022
MIFTS: 42

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 45

Classifications:



Summaries for Autoimmune Myocarditis

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NIH Rare Diseases:45 Autoimmune myocarditis is an autoimmune disease that affects the heart. the condition is characterized by inflammation of the heart muscle (myocardium). some people with autoimmune myocarditis have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. the exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. treatment is based on the signs and symptoms present in each person. in some cases, medications that suppress the immune system may be recommended. last updated: 2/23/2016

MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and non-distal monosomy 10q. An important gene associated with Autoimmune Myocarditis is TNF (Tumor Necrosis Factor), and among its related pathways are Downstream signaling in naive CD8+ T cells and TGF Beta Signaling Pathway. Affiliated tissues include heart, t cells and thyroid, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis11.0
2non-distal monosomy 10q10.4IFNG, TNF
3ethmoid sinus squamous cell carcinoma10.4IFNG, TNF
4parasitic ichthyosporea infectious disease10.4IFNG, TNF
5gonococcal bursitis10.4IFNG, TNF
6opisthorchiasis10.4IFNG, TNF
7collagenous colitis10.4IFNG, TNF
8atrichia with papular lesions10.4IFNG, TNF
9hypercementosis10.4IFNG, TNF
10early-onset, autosomal dominant alzheimer disease10.4IFNG, TNF
11soft tissue sarcoma childhood10.4IFNG, TNF
12hydronephrosis10.4IFNG, TNF
13argentine hemorrhagic fever10.4IFNG, TNF
14b cell deficiency10.4IFNG, TNF
15cytoplasmic body myopathy10.4IFNG, TNF
16hemorrhagic proctocolitis10.4IFNG, TNF
17dancing eyes-dancing feet syndrome10.4IFNG, TNF
18hemolytic anemia10.4IFNG, TNF
19cryptosporidiosis10.4IFNG, TNF
20central nervous system melanocytic neoplasm10.4IFNG, TNF
21proliferative fasciitis10.4IFNG, TNF
22soft palate cancer10.4IFNG, TNF
23chronic tic disorder10.4IFNG, TNF
24peripheral retinal degeneration10.4IFNG, TNF
25hepatoid adenocarcinoma10.4IFNG, TNF
26cervix melanoma10.4IFNG, TNF
27trench fever10.4IFNG, TNF
28acute leukemia of ambiguous lineage10.4IFNG, TNF
29meige syndrome10.3IFNG, TNF
30vagus nerve neoplasm10.3IFNG, TNF
31cryoglobulinemia10.3IFNG, TNF
32byssinosis10.3IFNG, TNF
33tracheal stenosis10.3IFNG, TNF
34tuberculoid leprosy10.3IFNG, TNF
35tethered spinal cord syndrome10.3IFNG, TNF
36blastomycosis10.3IFNG, TNF
37acute orbital inflammation10.3IFNG, TNF
38leech infestation10.3IFNG, TNF
39colon sarcoma10.3IFNG, TNF
40conventional malignant hemangiopericytoma10.3IFNG, TNF
41porphyria10.3IFNG, TNF
42reflex sympathetic dystrophy10.3IFNG, TNF
43renal oncocytoma10.3IFNG, TNF
44motion sickness10.3IFNG, TNF
45miliary tuberculosis10.3IFNG, TNF
46acute gonococcal epididymo-orchitis10.3IFNG, TNF
47leukoplakia of penis10.3IFNG, TNF
48dentin dysplasia10.3IFNG, TNF
49bronchopulmonary dysplasia10.3IFNG, TNF
50necatoriasis10.3IFNG, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Infliximabapproved349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
2
Adalimumabapproved443331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
3
Etanerceptapproved, investigational383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
Certolizumab pegolapproved117428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
Cimzia
D03441
5Antirheumatic Agents8496
6Immunologic Factors18483
7Immunosuppressive Agents10422

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Inflammation in Systemic Lupus ErythematosusRecruitingNCT01761422
2RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

33
Heart, T cells, Thyroid, Liver, Lung, Breast, Endothelial

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6IFNG, PPARA, PPARG, TNF
2MP:00030128.1CD274, IFNG, PPARG, TNF
3MP:00053698.1IFNG, PPARA, PPARG, TNF
4MP:00107717.8CD274, IFNG, PPARA, PPARG, TNF
5MP:00053847.5CD274, IFNG, PPARA, PPARG, TNF
6MP:00053877.5CD274, IFNG, PPARA, PPARG, TNF

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 353)
idTitleAuthorsYear
1
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. (26696258)
2016
2
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. (26658748)
2016
3
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. (26772776)
2016
4
Recent advances in the management of autoimmune myocarditis: insights from animal studies. (26696255)
2016
5
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. (26621778)
2016
6
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. (26899795)
2016
7
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. (27099262)
2016
8
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
9
Localization of CD8 T cell epitope within cardiac myosin heavy chain-I+334-352 that induces autoimmune myocarditis in A/J mice. (26422020)
2015
10
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. (25297507)
2014
11
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis. (23671208)
2013
12
Multimodality imaging and the emerging role of cardiac magnetic resonance in autoimmune myocarditis. (22617620)
2012
13
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
14
HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17-cell expansion. (21928275)
2011
15
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
16
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis. (17588693)
2008
17
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
18
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis. (18760191)
2008
19
Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. (18403598)
2008
20
Attenuation of autoimmune myocarditis in rats by mesenchymal stem cell transplantation through enhanced expression of hepatocyte growth factor. (17998774)
2007
21
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
22
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation. (16698032)
2006
23
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
24
Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. (16018993)
2005
25
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
26
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. (16316965)
2005
27
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
28
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
29
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
30
Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis. (15061762)
2004
31
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
32
Peroxisome proliferation-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis. (14499870)
2003
33
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
34
Detection of experimental autoimmune myocarditis in rats by 111In monoclonal antibody specific for tenascin-C. (12221059)
2002
35
Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression. (12123771)
2002
36
Levels of MCP-1 and GM-CSF mRNA correlated with inflammatory cytokines mRNA levels in experimental autoimmune myocarditis in rats. (12071442)
2002
37
Contribution of the innate immune system to autoimmune myocarditis: a role for complement. (11477411)
2001
38
The transition from viral to autoimmune myocarditis. (11908774)
2001
39
FTY720 prevents development of experimental autoimmune myocarditis through reduction of circulating lymphocytes. (10710126)
2000
40
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
41
Increases in cyclic AMP levels couple to H1 receptors in atria from autoimmune myocarditis mice. (8593244)
1995
42
Anti-alpha beta T cell receptor antibody prevents the progression of experimental autoimmune myocarditis. (8004817)
1994
43
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
44
Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice. (18475540)
1993
45
Role of IL-1 and tumor necrosis factor in coxsackie virus-induced autoimmune myocarditis. (8335952)
1993
46
Anitschkow cells in experimental autoimmune myocarditis. (1423981)
1992
47
Beta-adrenergic cardiac antibody in autoimmune myocarditis. (2562378)
1989
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5IFNG, TNF
29.5IFNG, TNF
39.5IFNG, TNF
49.5IFNG, TNF
59.5IFNG, TNF
6
Show member pathways
9.5IFNG, TNF
79.5IFNG, TNF
89.5IFNG, TNF
99.5IFNG, TNF
109.5IFNG, TNF
119.5IFNG, TNF
129.5IFNG, TNF
13
Show member pathways
9.5IFNG, TNF
14
Show member pathways
9.5IFNG, TNF
159.5PPARA, TNF
169.4PPARG, TNF
17
Show member pathways
9.3PPARA, PPARG
18
Show member pathways
9.3PPARA, PPARG
199.3PPARA, PPARG
209.2CD274, TNF
21
Show member pathways
8.9IFNG, PPARG, TNF
228.9IFNG, PPARG, TNF
238.9PPARA, PPARG, TNF
24
Show member pathways
8.9PPARA, PPARG, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
2positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
3positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
4negative regulation of growth of symbiont in hostGO:004413010.1IFNG, TNF
5positive regulation of fatty acid oxidationGO:004632110.0PPARA, PPARG
6negative regulation of cholesterol storageGO:001088710.0PPARA, PPARG
7protein import into nucleus, translocationGO:000006010.0IFNG, TNF
8response to virusGO:000961510.0IFNG, TNF
9positive regulation of cell adhesionGO:00457859.9IFNG, TNF
10positive regulation of osteoclast differentiationGO:00456729.9IFNG, TNF
11negative regulation of receptor biosynthetic processGO:00108719.9PPARA, PPARG
12regulation of insulin secretionGO:00507969.9IFNG, TNF
13regulation of circadian rhythmGO:00427529.8PPARA, PPARG
14negative regulation of smooth muscle cell proliferationGO:00486629.8IFNG, PPARG
15extrinsic apoptotic signaling pathwayGO:00971919.8IFNG, TNF
16negative regulation of gene expressionGO:00106299.7IFNG, TNF
17positive regulation of apoptotic processGO:00430659.7PPARG, TNF
18lipid metabolic processGO:00066299.7PPARA, PPARG
19cellular response to lipopolysaccharideGO:00712229.6IFNG, TNF
20activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.4PPARG, TNF
21defense response to bacteriumGO:00427429.4IFNG, TNF
22regulation of transcription, DNA-templatedGO:00063559.0IFNG, PPARA, PPARG
23immune responseGO:00069558.8CD274, IFNG, TNF
24positive regulation of transcription, DNA-templatedGO:00458938.8IFNG, PPARA, PPARG, TNF
25positive regulation of transcription from RNA polymerase II promoterGO:00459448.4IFNG, PPARA, PPARG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:00081449.3PPARA, PPARG

Sources for Autoimmune Myocarditis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet