MCID: ATM022
MIFTS: 42

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 50

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 50 autoimmune myocarditis is an autoimmune disease that affects the heart. the condition is characterized by inflammation of the heart muscle (myocardium). some people with autoimmune myocarditis have no noticeable symptoms of the condition. when present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. the exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. treatment is based on the signs and symptoms present in each person. in some cases, medications that suppress the immune system may be recommended. last updated: 2/23/2016

MalaCards based summary : Autoimmune Myocarditis is related to myocarditis and tubular renal disease-cardiomyopathy syndrome. An important gene associated with Autoimmune Myocarditis is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways/superpathways are IL-2 Pathway and Toll-like Receptor Signaling Pathway. The drugs Methotrexate and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are cellular and growth/size/body region

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
id Related Disease Score Top Affiliating Genes
1 myocarditis 10.9
2 tubular renal disease-cardiomyopathy syndrome 10.2 IL4 TNF
3 lagophthalmos 10.1 IL4 TNF
4 conidiobolomycosis 10.1 IL4 TNF
5 vestibule of mouth cancer 10.1 IL4 TNF
6 cardiomyopathy 10.1
7 intracranial arteriosclerosis 10.1 SPP1 TNF
8 congenital hypothyroidism 10.1 IL4 TNF
9 mikulicz disease 10.1 IL4 TNF
10 myoglobinuria recurrent 10.1 IFNG IL4
11 asymptomatic neurosyphilis 10.1 IFNG IL4
12 gonococcal endophthalmia 10.1 IL4 TNF
13 stocco dos santos syndrome 10.1 IFNG TNF
14 distal trisomy 14q 10.1 IFNG TNF
15 tungiasis 10.1 IFNG IL4
16 autosomal recessive type iv ehlers-danlos syndrome 10.1 IL4 TNF
17 crustacean allergy 10.1 IFNG IL4
18 leydig cell hypoplasia 10.1 SPP1 TNF
19 aniseikonia 10.1 IFNG TNF
20 centronuclear myopathy 5 10.1 IFNG IL4
21 esophagus lymphoma 10.1 IFNG TNF
22 acute gonococcal prostatitis 10.1 IFNG IL4
23 spastic paraplegia 1 10.1 IFNG TNF
24 parkinson disease 11 10.1 IFNG TNF
25 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.1 IFNG TNF
26 cutaneous fibrous histiocytoma 10.1 IFNG IL4
27 ovarian papillary cystadenoma 10.1 IFNG IL4
28 isolated klippel-feil syndrome 10.1 IFNG IL4
29 glucose intolerance 10.1 IFNG TNF
30 senile reticular retinal degeneration 10.1 IFNG TNF
31 conduct disorder 10.1 IFNG TNF
32 pancreatic signet ring cell adenocarcinoma 10.1 IFNG TNF
33 hyperinsulinism due to glutamodehydrogenase deficiency 10.1 IFNG IL4
34 pulpitis 10.1 IFNG TNF
35 hypertropia 10.1 IFNG TNF
36 immune-complex glomerulonephritis 10.1 IFNG IL4
37 hereditary alpha tryptasemia syndrome 10.1 IFNG TNF
38 rickettsialpox 10.1 IFNG TNF
39 erb-duchenne and dejerine-klumpke palsies 10.1 IFNG TNF
40 benign deep fibrous histiocytoma 10.1 IFNG TNF
41 plummer's disease 10.1 IFNG TNF
42 peripheral artery disease 10.0 IL4 TNF
43 hydrophthalmos 10.0 IFNG IL4
44 steatitis 10.0 IL2 TNF
45 loiasis 10.0 IFNG IL4
46 sarcoma 10.0 IL2 IL4
47 vulvar vestibulitis syndrome 10.0 IL2 IL4
48 disease of mental health 10.0 IFNG TNF
49 dilated cardiomyopathy 10.0
50 thymic neuroendocrine carcinoma 10.0 IL2 TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.04 IFNG IL2 IL4 PPARG SPP1 TNF
2 growth/size/body region MP:0005378 10.01 IL2 IL4 PPARG SPP1 TNF IFNG
3 hematopoietic system MP:0005397 10 IFNG IL2 IL4 PPARG SPP1 TNF
4 homeostasis/metabolism MP:0005376 9.99 IFNG IL2 IL4 PPARG SPP1 TNF
5 cardiovascular system MP:0005385 9.97 IFNG IL2 PPARG SPP1 TNF
6 immune system MP:0005387 9.97 IFNG IL2 IL4 PPARG SPP1 TNF
7 endocrine/exocrine gland MP:0005379 9.95 IFNG IL2 IL4 PPARG TNF
8 liver/biliary system MP:0005370 9.93 IFNG IL2 IL4 PPARG SPP1 TNF
9 mortality/aging MP:0010768 9.91 IFNG IL2 IL4 PPARG SPP1 TNF
10 integument MP:0010771 9.88 SPP1 TNF IFNG IL4 PPARG
11 craniofacial MP:0005382 9.86 TNF IFNG IL4 SPP1
12 neoplasm MP:0002006 9.8 IFNG IL2 PPARG SPP1 TNF
13 no phenotypic analysis MP:0003012 9.77 IFNG IL2 IL4 PPARG TNF
14 reproductive system MP:0005389 9.73 IFNG IL2 IL4 PPARG SPP1 TNF
15 renal/urinary system MP:0005367 9.62 IFNG IL4 PPARG SPP1
16 respiratory system MP:0005388 9.55 SPP1 TNF IFNG IL2 IL4
17 skeleton MP:0005390 9.35 IFNG IL4 PPARG SPP1 TNF
18 vision/eye MP:0005391 9.02 IFNG IL2 IL4 PPARG TNF

Drugs & Therapeutics for Autoimmune Myocarditis

Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4 185243-69-0
4
Infliximab Approved Phase 4 170277-31-3
5
Certolizumab pegol Approved Phase 4 428863-50-7
6 Antirheumatic Agents Phase 4

Interventional clinical trials:


id Name Status NCT ID Phase
1 RHYTHM (Formerly Escape II Myocardium) Recruiting NCT01548768 Phase 4
2 Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) Infection Not yet recruiting NCT02787382 Phase 3
3 Myocardial Inflammation in Systemic Lupus Erythematosus Unknown status NCT01761422
4 Cardiac and Laboratory Findings in Patients With Systemic Lupus Erythematosus Not yet recruiting NCT03179046

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

39
Heart, T Cells, Monocytes, Bone, B Cells, Lung, Thymus

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 363)
id Title Authors Year
1
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
2
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016
3
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
4
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
5
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. ( 26696258 )
2016
6
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. ( 27342875 )
2016
7
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. ( 27501378 )
2016
8
Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 27818491 )
2016
9
Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats. ( 26946470 )
2016
10
Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 26657007 )
2016
11
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. ( 27502060 )
2016
12
Recent advances in the management of autoimmune myocarditis: insights from animal studies. ( 26696255 )
2016
13
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. ( 26772776 )
2016
14
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. ( 27288745 )
2016
15
Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder. ( 27095924 )
2016
16
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. ( 26899795 )
2016
17
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. ( 26660726 )
2016
18
Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM). ( 27501319 )
2016
19
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. ( 26621778 )
2016
20
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. ( 26658748 )
2016
21
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. ( 27044832 )
2016
22
Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. ( 27052830 )
2016
23
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. ( 27390159 )
2016
24
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. ( 27184135 )
2016
25
Mouse Models of Autoimmune Diseases - Autoimmune Myocarditis. ( 25777763 )
2015
26
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. ( 25901283 )
2015
27
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. ( 26475067 )
2015
28
Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis. ( 25596465 )
2015
29
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. ( 26768489 )
2015
30
Anti-inflammatory Role of Obestatin in Autoimmune myocarditis. ( 26426263 )
2015
31
A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice. ( 25768281 )
2015
32
Intravital microscopy -A novel toolin characterizing congestive heart failurein experimental autoimmune myocarditis. ( 26484717 )
2015
33
Localization of CD8 T cell epitope within cardiac myosin heavy chain-I+334-352 that induces autoimmune myocarditis in A/J mice. ( 26422020 )
2015
34
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis. ( 24269624 )
2014
35
Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease. ( 24732212 )
2014
36
N-Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide. ( 25147347 )
2014
37
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis. ( 24189626 )
2014
38
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. ( 25297507 )
2014
39
Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5. ( 25431156 )
2014
40
Blocking the receptor for advanced glycation end product activation attenuates autoimmune myocarditis. ( 24599045 )
2014
41
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease. ( 25191648 )
2014
42
Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. ( 24205804 )
2014
43
Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy. ( 25551279 )
2014
44
Mortality and Morbidity in Different Immunization Protocols for Experimental Autoimmune Myocarditis in Rats. ( 24410878 )
2014
45
Tenascin-C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation. ( 25376187 )
2014
46
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse. ( 24998332 )
2014
47
Experimental drugs for treatment of autoimmune myocarditis. ( 25146626 )
2014
48
A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4(+) T and macrophage infiltration and NADPH oxidase 2/4 expression in mice. ( 24879505 )
2014
49
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. ( 24447632 )
2014
50
Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction. ( 21684025 )
2013

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 IFNG IL2 IL4 SPP1 TNF
2
Show member pathways
12.74 IFNG IL2 SPP1 TNF
3
Show member pathways
12.7 IFNG IL2 IL4 TNF
4
Show member pathways
12.64 IFNG IL2 IL4 TNF
5
Show member pathways
12.49 IFNG IL2 IL4 TNF
6
Show member pathways
12.46 IFNG IL2 IL4 TNF
7 12.4 IL2 IL4 SPP1
8
Show member pathways
12.4 IFNG IL2 TNF
9 12.4 IFNG IL2 IL4 TNF
10
Show member pathways
12.38 IFNG IL2 IL4 TNF
11
Show member pathways
12.27 IFNG IL2 IL4 TNF
12
Show member pathways
12.19 IFNG IL4 TNF
13
Show member pathways
12.13 IFNG IL2 IL4 TNF
14
Show member pathways
12.12 IFNG IL4 TNF
15
Show member pathways
12.08 IFNG IL2 IL4
16
Show member pathways
12.06 IFNG IL4 TNF
17 11.93 IFNG PPARG TNF
18
Show member pathways
11.88 IFNG IL2 IL4 TNF
19
Show member pathways
11.87 IFNG IL2 IL4
20
Show member pathways
11.84 IFNG IL2 TNF
21 11.72 IFNG IL2 IL4
22 11.7 IFNG IL2 IL4 TNF
23 11.67 IFNG IL2 TNF
24 11.63 IFNG IL2 IL4 TNF
25 11.57 IL4 SPP1 TNF
26
Show member pathways
11.56 IFNG IL2 TNF
27
Show member pathways
11.54 IFNG IL2 TNF
28 11.51 IFNG SPP1 TNF
29 11.43 IFNG IL2 TNF
30
Show member pathways
11.4 IFNG TNF
31 11.39 IL4 TNF
32 11.39 IFNG TNF
33 11.39 IFNG IL2 TNF
34 11.37 IFNG TNF
35 11.37 IFNG IL2 IL4
36 11.36 IFNG IL2 IL4 TNF
37 11.34 IFNG SPP1 TNF
38
Show member pathways
11.26 IFNG IL2 TNF
39 11.23 IFNG TNF
40 11.15 IFNG IL2 IL4
41 11.13 IFNG IL2
42 11.11 IFNG IL4 TNF
43 11.08 IL2 IL4 TNF
44 11.02 PPARG TNF
45 11 IFNG IL2 IL4
46
Show member pathways
10.9 IFNG IL2 IL4 PPARG TNF
47 10.73 IFNG IL2 IL4 TNF

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 IFNG IL2 IL4 SPP1 TNF
2 external side of plasma membrane GO:0009897 9.13 IFNG IL4 TNF
3 extracellular space GO:0005615 9.02 IFNG IL2 IL4 SPP1 TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 36)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.89 IFNG IL2 IL4 PPARG TNF
2 negative regulation of transcription, DNA-templated GO:0045892 9.87 IFNG IL4 PPARG TNF
3 immune response GO:0006955 9.86 IFNG IL2 IL4 TNF
4 positive regulation of apoptotic process GO:0043065 9.83 IFNG PPARG TNF
5 response to drug GO:0042493 9.83 IFNG IL4 PPARG
6 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.72 IL4 PPARG TNF
7 response to organic substance GO:0010033 9.69 PPARG SPP1 TNF
8 humoral immune response GO:0006959 9.67 IFNG TNF
9 positive regulation of cell adhesion GO:0045785 9.67 IFNG TNF
10 positive regulation of interferon-gamma production GO:0032729 9.66 IL2 TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 IFNG TNF
12 extrinsic apoptotic signaling pathway GO:0097191 9.65 IFNG TNF
13 positive regulation of transcription, DNA-templated GO:0045893 9.65 IFNG IL4 PPARG SPP1 TNF
14 positive regulation of B cell proliferation GO:0030890 9.64 IL2 IL4
15 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.64 IL2 IL4
16 negative regulation of smooth muscle cell proliferation GO:0048662 9.63 IFNG PPARG
17 protein import into nucleus, translocation GO:0000060 9.63 IFNG TNF
18 positive regulation of activated T cell proliferation GO:0042104 9.62 IL2 IL4
19 positive regulation of protein complex assembly GO:0031334 9.62 IFNG TNF
20 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
21 defense response to protozoan GO:0042832 9.61 IFNG IL4
22 positive regulation of T cell proliferation GO:0042102 9.61 IFNG IL2 IL4
23 positive regulation of T cell differentiation GO:0045582 9.6 IL2 IL4
24 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.59 IL2 IL4
25 negative regulation of growth of symbiont in host GO:0044130 9.58 IFNG TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
27 negative regulation of acute inflammatory response GO:0002674 9.54 IL4 PPARG
28 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IFNG IL2 IL4
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.52 IFNG IL4
30 negative regulation of T-helper 17 cell differentiation GO:2000320 9.48 IL2 IL4
31 positive regulation of mononuclear cell migration GO:0071677 9.46 IL4 TNF
32 positive regulation of protein phosphorylation GO:0001934 9.46 IFNG IL2 IL4 TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 IFNG TNF
34 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 IFNG TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.13 IFNG IL4 TNF
36 positive regulation of isotype switching to IgG isotypes GO:0048304 8.8 IFNG IL2 IL4

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL2 IL4 SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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