MCID: ATM022
MIFTS: 40

Autoimmune Myocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 49

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 49 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended. Last updated: 2/23/2016

MalaCards based summary : Autoimmune Myocarditis is related to thyroiditis and rheumatic heart disease. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are cardiovascular system and cellular

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 thyroiditis 29.7 IFNG IL2
2 rheumatic heart disease 29.6 TNF VCAM1
3 autoimmune disease 29.5 IFNG IL2 TNF
4 celiac disease 1 29.3 IFNG IL2 TNF
5 endocarditis 29.2 TNF VCAM1
6 systemic lupus erythematosus 27.7 IFNG IL2 SPP1 TNF VCAM1
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 11.0
8 myocarditis 10.9
9 staphylococcal toxic shock syndrome 10.3 IFNG TNF
10 variola major 10.3 IFNG IL2
11 berylliosis 10.3 IFNG IL2
12 chronic beryllium disease 10.3 IFNG TNF
13 trichosporonosis 10.3 IFNG TNF
14 immune suppression 10.3 IFNG IL2
15 atopic keratoconjunctivitis 10.3 IFNG IL2
16 orofacial granulomatosis 10.3 IFNG TNF
17 meconium aspiration syndrome 10.3 IFNG TNF
18 central nervous system vasculitis 10.3 IFNG TNF
19 tuberculous peritonitis 10.3 IFNG TNF
20 chronic active epstein-barr virus infection 10.3 IFNG IL2
21 soft tissue sarcoma 10.3 IFNG TNF
22 cytomegalovirus retinitis 10.3 IFNG TNF
23 poliomyelitis 10.2 IFNG TNF
24 primary systemic mycosis 10.2 IFNG TNF
25 vulvovaginal candidiasis 10.2 IFNG IL2
26 eales disease 10.2 IFNG TNF
27 hemorrhagic fever 10.2 IFNG TNF
28 aseptic meningitis 10.2 IFNG TNF
29 pleural tuberculosis 10.2 IFNG TNF
30 spotted fever 10.2 IFNG TNF
31 lichen disease 10.2 IFNG TNF
32 plasmodium vivax malaria 10.2 IFNG TNF
33 q fever 10.2 IFNG TNF
34 hepatitis e 10.2 IFNG TNF
35 autoimmune disease of endocrine system 10.2 IFNG IL2
36 rasmussen encephalitis 10.2 IFNG TNF
37 opportunistic mycosis 10.2 IFNG TNF
38 herpes zoster 10.2 IFNG IL2
39 oral tuberculosis 10.2 IL2 TNF
40 vernal conjunctivitis 10.2 IFNG IL2
41 mixed connective tissue disease 10.2 IFNG TNF
42 echinococcosis 10.2 IFNG TNF
43 melioidosis 10.2 IFNG TNF
44 reactive arthritis 10.2 IFNG TNF
45 typhoid fever 10.2 IFNG TNF
46 streptococcal toxic-shock syndrome 10.2 IL2 TNF
47 dengue hemorrhagic fever 10.2 IFNG TNF
48 farmer's lung 10.2 IL2 TNF
49 mumps 10.2 IFNG IL2
50 neuritis 10.2 IFNG TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 PPARG VCAM1 IFNG SPP1 IL2 TNF
2 cellular MP:0005384 9.95 VCAM1 PPARG IFNG SPP1 IL2 TNF
3 growth/size/body region MP:0005378 9.93 VCAM1 PPARG IFNG SPP1 IL2 TNF
4 hematopoietic system MP:0005397 9.91 VCAM1 PPARG IFNG SPP1 IL2 TNF
5 homeostasis/metabolism MP:0005376 9.88 VCAM1 TNF PPARG IFNG SPP1 IL2
6 immune system MP:0005387 9.85 VCAM1 PPARG IFNG SPP1 IL2 TNF
7 mortality/aging MP:0010768 9.73 VCAM1 TNF PPARG IFNG SPP1 IL2
8 liver/biliary system MP:0005370 9.72 PPARG IFNG SPP1 IL2 TNF
9 neoplasm MP:0002006 9.55 IFNG SPP1 IL2 TNF PPARG
10 no phenotypic analysis MP:0003012 9.35 VCAM1 PPARG IFNG IL2 TNF
11 reproductive system MP:0005389 9.1 VCAM1 IFNG SPP1 IL2 TNF PPARG

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

38
Heart, T Cells, Monocytes, B Cells, Bone, Lung, Thymus

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 388)
# Title Authors Year
1
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
2
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
3
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
4
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
5
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-I_B and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
6
Branched chain I+-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
7
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
8
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
9
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
10
Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. ( 29052263 )
2017
11
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. ( 28474508 )
2017
12
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
13
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
14
A humanized HLA-DR4 mouse model for autoimmune myocarditis. ( 28431892 )
2017
15
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis. ( 28875521 )
2017
16
I^1-Adrenergic Receptor Contains Multiple IA<sup>k</sup>and IE<sup>k</sup>Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. ( 29209317 )
2017
17
Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. ( 28887037 )
2017
18
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
19
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
20
Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 28178619 )
2017
21
The protective effects of taurine on experimental autoimmune myocarditis. ( 28485791 )
2017
22
FGL2 deteriorates cardiac function in experimental autoimmune myocarditis rats through regulation of PD-1 and inflammatory cytokines. ( 28892130 )
2017
23
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
24
Carvedilol Inhibits Matrix Metalloproteinase-2 Activation in Experimental Autoimmune Myocarditis: Possibilities of Cardioprotective Application. ( 28854816 )
2017
25
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
26
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
27
Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM). ( 27501319 )
2016
28
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
29
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. ( 26621778 )
2016
30
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. ( 27501378 )
2016
31
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016
32
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. ( 27502060 )
2016
33
Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. ( 27052830 )
2016
34
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. ( 27342875 )
2016
35
Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 26657007 )
2016
36
Recent advances in the management of autoimmune myocarditis: insights from animal studies. ( 26696255 )
2016
37
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. ( 27044832 )
2016
38
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. ( 26772776 )
2016
39
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. ( 26658748 )
2016
40
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. ( 26660726 )
2016
41
Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder. ( 27095924 )
2016
42
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. ( 27288745 )
2016
43
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. ( 26696258 )
2016
44
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
45
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. ( 26899795 )
2016
46
Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats. ( 26946470 )
2016
47
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. ( 27390159 )
2016
48
Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 27818491 )
2016
49
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. ( 27184135 )
2016
50
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. ( 26475067 )
2015

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 IFNG IL2 TNF VCAM1
2
Show member pathways
12.97 IFNG IL2 SPP1 TNF
3
Show member pathways
12.42 IFNG IL2 TNF
4
Show member pathways
12.39 IFNG IL2 TNF
5
Show member pathways
12.38 IFNG IL2 TNF
6 12.34 IFNG IL2 TNF VCAM1
7
Show member pathways
12.31 IFNG IL2 TNF
8
Show member pathways
12.3 IFNG IL2 SPP1 TNF
9
Show member pathways
12.23 IFNG IL2 TNF
10 12.22 IL2 TNF VCAM1
11
Show member pathways
12.14 IFNG IL2 TNF
12
Show member pathways
11.98 IFNG IL2 TNF
13 11.92 IFNG TNF VCAM1
14 11.87 IFNG PPARG TNF
15 11.84 IFNG IL2 TNF
16 11.82 IFNG IL2 TNF
17
Show member pathways
11.76 IFNG IL2 TNF
18 11.72 PPARG SPP1 VCAM1
19 11.63 IFNG IL2 TNF
20 11.58 IFNG IL2 TNF
21 11.51 TNF VCAM1
22 11.51 IFNG IL2
23 11.51 PPARG TNF
24 11.49 SPP1 TNF
25
Show member pathways
11.46 IFNG IL2 TNF
26 11.42 IFNG SPP1 TNF
27
Show member pathways
11.38 IFNG TNF
28 11.36 IFNG TNF
29 11.34 IFNG IL2 TNF
30 11.33 IFNG IL2
31 11.31 IFNG VCAM1
32 11.3 IFNG TNF VCAM1
33 11.26 IFNG IL2 TNF
34 11.2 IFNG SPP1 TNF
35 11.17 IFNG IL2
36 11.16 IFNG TNF
37
Show member pathways
11.14 IFNG IL2 PPARG TNF
38 11.08 IFNG IL2
39 11.05 IFNG IL2
40
Show member pathways
11.05 IFNG IL2 TNF
41 10.98 IFNG TNF VCAM1
42 10.97 TNF VCAM1
43 10.96 PPARG TNF
44 10.82 TNF VCAM1
45 10.81 IFNG IL2 TNF
46
Show member pathways
10.72 IFNG IL2 TNF VCAM1

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 IFNG IL2 SPP1 TNF VCAM1

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.65 SPP1 TNF VCAM1
2 regulation of insulin secretion GO:0050796 9.59 IFNG TNF
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL2
4 positive regulation of T cell proliferation GO:0042102 9.58 IL2 VCAM1
5 humoral immune response GO:0006959 9.57 IFNG TNF
6 positive regulation of interferon-gamma production GO:0032729 9.56 IL2 TNF
7 regulation of receptor activity GO:0010469 9.56 IFNG IL2 SPP1 TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.55 IFNG TNF
9 extrinsic apoptotic signaling pathway GO:0097191 9.54 IFNG TNF
10 positive regulation of protein phosphorylation GO:0001934 9.54 IFNG IL2 TNF
11 negative regulation of smooth muscle cell proliferation GO:0048662 9.52 IFNG PPARG
12 protein import into nucleus, translocation GO:0000060 9.51 IFNG TNF
13 positive regulation of protein complex assembly GO:0031334 9.49 IFNG TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.46 IFNG TNF
15 leukocyte tethering or rolling GO:0050901 9.43 TNF VCAM1
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 IFNG TNF
17 response to organic substance GO:0010033 9.33 PPARG SPP1 TNF
18 regulation of regulatory T cell differentiation GO:0045589 9.32 IFNG IL2
19 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IFNG TNF
20 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL2 SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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