MCID: ATM022
MIFTS: 41

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 47

Classifications:



Summaries for Autoimmune Myocarditis

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MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and myoclonus epilepsy. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways are Malaria and Cellular Transformation by HTLV1. Affiliated tissues include t cells, heart and b cells, and related mouse phenotypes are craniofacial and renal/urinary system.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis10.9
2myoclonus epilepsy10.4IFNG, IL4
3eye accommodation disease10.4IFNG, IL4
4panner disease10.4IFNG, TNF
5baetz-greenwalt syndrome10.4IFNG, TNF
6motor peripheral neuropathy10.4IFNG, IL4
7nut allergy10.4IFNG, IL4
8thelaziasis10.4IFNG, IL4
9primary systemic mycosis10.3IFNG, TNF
10goat milk allergy10.3IFNG, IL4
11buruli ulcer10.3IFNG, IL4
12pasteurellosis10.3IFNG, TNF
13acute gonococcal salpingitis10.3IFNG, IL4
14cervix melanoma10.3IFNG, IL4
15steatorrhea10.3IFNG, TNF
16hernia of ovary and fallopian tube10.3IFNG, TNF
17stampe sorensen syndrome10.3IFNG, TNF
18pseudoretinitis pigmentosa10.3IFNG, TNF
19multiple system atrophy, cerebellar type10.3IFNG, IL4
20sensorineural hearing loss10.3IFNG, TNF
21psychologic dyspareunia10.3IFNG, TNF
22mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3IFNG, TNF
23multicentric castleman disease10.3IFNG, IL4
24hemophagocytic lymphohistiocytosis10.3IFNG, TNF
25leukostasis10.3IFNG, TNF
26fibrous histiocytoma10.3IFNG, TNF
27dementia - subcortical10.3IFNG, TNF
28buphthalmos10.3IFNG, IL4
29tetanus neonatorum10.3IFNG, IL4
30gastric dilatation10.3IFNG, TNF
31bile duct signet ring cell carcinoma10.3IFNG, TNF
32ehlers-danlos syndrome, musculocontractural type10.3IFNG, TNF
336q terminal deletion syndrome10.3IL4, TNF
34corneal intraepithelial neoplasm10.3IFNG, TNF
35basidiobolomycosis10.3IL4, TNF
36reproductive system disease10.3IFNG, TNF
37paralytic lagophthalmos10.3IL4, TNF
38progressive relapsing multiple sclerosis10.3IFNG, IL4
39cutaneous porphyria10.3IFNG, TNF
40spondylolysis10.3IFNG, TNF
41rhizomelic chondrodysplasia punctata10.2IFNG, TNF
42neurotic excoriation10.2IL4, TNF
43peripheral t-cell lymphoma10.2IL4, TNF
44burn scar10.2IFNG, TNF
45alkhurma hemorrhagic fever10.2IL4, TNF
46peanut allergy10.2IL4, TNF
47gait apraxia10.2IL4, TNF
48dentinogenesis imperfecta10.2IFNG, TNF
49inner ear disease10.2IFNG, TNF
50senile cataract10.2IL4, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms for Autoimmune Myocarditis

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Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Certolizumab pegolapproved122428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
2
Etanerceptapproved, investigational397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
3
Infliximabapproved378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
4
Adalimumabapproved478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
5Immunosuppressive Agents12770
6Gastrointestinal Agents8109
7Dermatologic Agents5674
8Anti-Inflammatory Agents10355
9Antirheumatic Agents10627

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) InfectionNot yet recruitingNCT02787382Phase 3
2Myocardial Inflammation in Systemic Lupus ErythematosusUnknown statusNCT01761422
3RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

35
T cells, Heart, B cells, Bone, Monocytes, Lung, Thymus

Animal Models for Autoimmune Myocarditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Myocarditis:

40 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.6IFNG, IL4, SPP1, TNF
2MP:00053678.5IFNG, IL4, PPARG, SPP1
3MP:00053908.3IFNG, IL4, PPARG, SPP1, TNF
4MP:00107718.2IFNG, IL4, PPARG, SPP1, TNF
5MP:00053798.1IFNG, IL2, IL4, PPARG, TNF
6MP:00030128.0IFNG, IL2, IL4, PPARG, TNF
7MP:00020068.0IFNG, IL2, PPARG, SPP1, TNF
8MP:00053888.0IFNG, IL2, IL4, SPP1, TNF
9MP:00053897.5IFNG, IL2, IL4, PPARG, SPP1, TNF
10MP:00053707.5IFNG, IL2, IL4, PPARG, SPP1, TNF
11MP:00053847.4IFNG, IL2, IL4, PPARG, SPP1, TNF
12MP:00053857.3IFNG, IL2, PPARG, SPP1, TNF
13MP:00053877.3IFNG, IL2, IL4, PPARG, SPP1, TNF
14MP:00053977.2IFNG, IL2, IL4, PPARG, SPP1, TNF
15MP:00107687.2IFNG, IL2, IL4, PPARG, SPP1, TNF
16MP:00053787.1IFNG, IL2, IL4, PPARG, SPP1, TNF
17MP:00053767.0IFNG, IL2, IL4, PPARG, SPP1, TNF

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
Recent advances in the management of autoimmune myocarditis: insights from animal studies. (26696255)
2016
2
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. (27342875)
2016
3
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. (26621778)
2016
4
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. (27501378)
2016
5
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. (27440853)
2016
6
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
7
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. (26768489)
2015
8
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. (24447632)
2014
9
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease. (25191648)
2014
10
Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5. (25431156)
2014
11
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse. (24998332)
2014
12
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013
13
The periodontal pathogen aggregatibacter actinomycetemcomitans affects experimental autoimmune myocarditis in mice. (24309453)
2013
14
Cooperation of Th1 and Th17 cells determines transition from autoimmune myocarditis to dilated cardiomyopathy. (22730043)
2012
15
Correlation of left ventricular wall thickness, heart mass, serological parameters and late gadolinium enhancement in cardiovascular magnetic resonance imaging of myocardial inflammation in an experimental animal model of autoimmune myocarditis. (22327939)
2012
16
Characterization of fibrosis-promoting factors and siRNA-mediated therapies in C-protein-induced experimental autoimmune myocarditis. (23099153)
2012
17
Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. (21927577)
2011
18
Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway. (19233196)
2009
19
Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis. (18608177)
2009
20
Future therapeutic strategies in inflammatory cardiomyopathy: insights from the experimental autoimmune myocarditis model. (19075632)
2008
21
CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. (18250481)
2008
22
Genetic complexity of autoimmune myocarditis. (18190873)
2008
23
Antiarrhythmic effect of atorvastatin on autoimmune myocarditis is mediated by improving myocardial repolarization. (17217967)
2007
24
Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides. (17235437)
2007
25
Immunoregulatory effects of atorvastatin on experimental autoimmune myocarditis in Lewis rats. (16509827)
2006
26
Increased expression of caveolin-1 and -2 in the hearts of Lewis rats with experimental autoimmune myocarditis. (17060028)
2006
27
A cyclooxygenase-2 inhibitor alters Th1/Th2 cytokine balance and suppresses autoimmune myocarditis in rats. (16499924)
2006
28
The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. (15902684)
2005
29
Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells. (15972947)
2005
30
Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balance. (15698832)
2005
31
Beneficial effects of olmesartan, a novel angiotensin II receptor type 1 antagonist, upon acute autoimmune myocarditis. (15124927)
2004
32
HMG-CoA reductase inhibitor attenuates experimental autoimmune myocarditis through inhibition of T cell activation. (15537494)
2004
33
Increased expression of phospholipase D in the heart with experimental autoimmune myocarditis in Lewis rats. (15015836)
2004
34
Monomethoxypolyethylene glycol-modified cardiac myosin treatment blocks the active and passive induction of experimental autoimmune myocarditis. (14745151)
2004
35
Amiodarone minimizes experimental autoimmune myocarditis in rats. (12782199)
2003
36
FR167653 suppresses the progression of experimental autoimmune myocarditis. (12841341)
2003
37
Time course of gene expression in rat experimental autoimmune myocarditis. (12444915)
2002
38
cis Element decoy against nuclear factor-kappaB attenuates development of experimental autoimmune myocarditis in rats. (11701617)
2001
39
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway. (11748115)
2001
40
Protection against autoimmune myocarditis by gene transfer of interleukin-10 by electroporation. (11535562)
2001
41
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis. (11041101)
2000
42
Experimental autoimmune myocarditis and its pathomechanism. (10904852)
2000
43
Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats. (9008468)
1997
44
Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity. (7869033)
1995
45
Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. (8083344)
1994
46
Cardiac muscle cell damage through autoimmune mechanism--can cardiac proteins provoke autoimmune myocarditis? (1749072)
1991
47
Muscarinic cholinergic antibody in experimental autoimmune myocarditis regulates cardiac function. (2175437)
1990
48
Exercise induced augmentation of cellular and humoral autoimmunity associated with increased cardiac dilatation in experimental autoimmune myocarditis. (3652088)
1987
49
Experimental autoimmune myocarditis in the guinea pig. (4053137)
1985
50
Autoimmune myocarditis induced by Trypanosoma cruzi. (3922642)
1985

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathwaysScoreTop Affiliating Genes
19.5IFNG, TNF
2
Show member pathways
9.5IFNG, TNF
39.5IFNG, TNF
49.5IFNG, TNF
59.2IFNG, IL2
69.1IFNG, PPARG, TNF
7
Show member pathways
9.0IFNG, IL4, TNF
8
Show member pathways
9.0IFNG, IL4, TNF
98.9IFNG, SPP1, TNF
108.9IFNG, SPP1, TNF
11
Show member pathways
8.7IFNG, IL2, TNF
128.7IFNG, IL2, TNF
138.7IFNG, IL2, TNF
14
Show member pathways
8.7IFNG, IL2, TNF
15
Show member pathways
8.7IFNG, IL2, TNF
16
Show member pathways
8.7IFNG, IL2, TNF
17
Show member pathways
8.7IFNG, IL2, IL4
18
Show member pathways
8.7IFNG, IL2, IL4
198.7IFNG, IL2, IL4
208.7IFNG, IL2, IL4
218.7IFNG, IL2, IL4
228.7IFNG, IL2, IL4
238.6IL2, IL4, TNF
248.5IL2, IL4, SPP1
25
Show member pathways
8.2IFNG, IL2, IL4, TNF
268.2IFNG, IL2, IL4, TNF
278.2IFNG, IL2, IL4, TNF
288.2IFNG, IL2, IL4, TNF
29
Show member pathways
8.2IFNG, IL2, IL4, TNF
30
Show member pathways
8.2IFNG, IL2, IL4, TNF
318.2IFNG, IL2, IL4, TNF
32
Show member pathways
8.2IFNG, IL2, IL4, TNF
33
Show member pathways
8.2IFNG, IL2, IL4, TNF
34
Show member pathways
8.2IFNG, IL2, IL4, TNF
358.2IFNG, IL2, IL4, TNF
36
Show member pathways
8.1IFNG, IL2, SPP1, TNF
37
Show member pathways
7.7IFNG, IL2, IL4, PPARG, TNF
38
Show member pathways
7.6IFNG, IL2, IL4, SPP1, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.0IFNG, IL4, TNF
2extracellular spaceGO:00056157.6IFNG, IL2, IL4, SPP1, TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
2positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
3positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
4negative regulation of acute inflammatory responseGO:000267410.2IL4, PPARG
5humoral immune responseGO:000695910.1IFNG, TNF
6protein import into nucleus, translocationGO:000006010.1IFNG, TNF
7extrinsic apoptotic signaling pathwayGO:009719110.1IFNG, TNF
8positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
9positive regulation of mononuclear cell migrationGO:007167710.1IL4, TNF
10defense response to protozoanGO:004283210.1IFNG, IL4
11positive regulation of osteoclast differentiationGO:004567210.1IFNG, TNF
12negative regulation of smooth muscle cell proliferationGO:004866210.1IFNG, PPARG
13positive regulation of cell adhesionGO:004578510.0IFNG, TNF
14negative regulation of growth of symbiont in hostGO:004413010.0IFNG, TNF
15positive regulation of nitric oxide biosynthetic processGO:00454299.8IFNG, TNF
16positive regulation of activated T cell proliferationGO:00421049.7IL2, IL4
17positive regulation of interferon-gamma productionGO:00327299.7IL2, TNF
18positive regulation of B cell proliferationGO:00308909.7IL2, IL4
19positive regulation of chemokine biosynthetic processGO:00450809.7IFNG, IL4, TNF
20positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.7IL2, IL4
21positive regulation of T cell differentiationGO:00455829.6IL2, IL4
22extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.6IL2, IL4
23positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.4IL4, PPARG, TNF
24positive regulation of isotype switching to IgG isotypesGO:00483049.3IFNG, IL2, IL4
25positive regulation of apoptotic processGO:00430659.3IFNG, PPARG, TNF
26response to organic substanceGO:00100339.2PPARG, SPP1, TNF
27positive regulation of T cell proliferationGO:00421029.1IFNG, IL2, IL4
28positive regulation of protein phosphorylationGO:00019349.1IL2, IL4, TNF
29positive regulation of transcription, DNA-templatedGO:00458938.8IFNG, IL4, PPARG, TNF
30response to drugGO:00424938.8IFNG, IL4, PPARG
31positive regulation of transcription from RNA polymerase II promoterGO:00459447.7IFNG, IL2, IL4, PPARG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051257.6IFNG, IL2, IL4, SPP1, TNF

Sources for Autoimmune Myocarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet