MCID: ATM022
MIFTS: 41

Autoimmune Myocarditis malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

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Aliases & Descriptions for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 48

Classifications:



Summaries for Autoimmune Myocarditis

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NIH Rare Diseases:48 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended. Last updated: 2/23/2016

MalaCards based summary: Autoimmune Myocarditis is related to myocarditis and myoclonus epilepsy. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways are Malaria and Cellular Transformation by HTLV1. Affiliated tissues include t cells, heart and b cells, and related mouse phenotypes are craniofacial and renal/urinary system.

Related Diseases for Autoimmune Myocarditis

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Diseases in the Myocarditis family:

Acute Myocarditis autoimmune myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1myocarditis10.9
2myoclonus epilepsy10.4IFNG, IL4
3eye accommodation disease10.4IFNG, IL4
4panner disease10.4IFNG, TNF
5baetz-greenwalt syndrome10.4IFNG, TNF
6motor peripheral neuropathy10.4IFNG, IL4
7nut allergy10.4IFNG, IL4
8thelaziasis10.4IFNG, IL4
9primary systemic mycosis10.3IFNG, TNF
10goat milk allergy10.3IFNG, IL4
11buruli ulcer10.3IFNG, IL4
12pasteurellosis10.3IFNG, TNF
13acute gonococcal salpingitis10.3IFNG, IL4
14cervix melanoma10.3IFNG, IL4
15steatorrhea10.3IFNG, TNF
16hernia of ovary and fallopian tube10.3IFNG, TNF
17stampe sorensen syndrome10.3IFNG, TNF
18pseudoretinitis pigmentosa10.3IFNG, TNF
19multiple system atrophy, cerebellar type10.3IFNG, IL4
20sensorineural hearing loss10.3IFNG, TNF
21psychologic dyspareunia10.3IFNG, TNF
22mastocytosis cutaneous with short stature conductive hearing loss and microtia10.3IFNG, TNF
23multicentric castleman disease10.3IFNG, IL4
24hemophagocytic lymphohistiocytosis10.3IFNG, TNF
25leukostasis10.3IFNG, TNF
26fibrous histiocytoma10.3IFNG, TNF
27dementia - subcortical10.3IFNG, TNF
28buphthalmos10.3IFNG, IL4
29tetanus neonatorum10.3IFNG, IL4
30gastric dilatation10.3IFNG, TNF
31bile duct signet ring cell carcinoma10.3IFNG, TNF
32ehlers-danlos syndrome, musculocontractural type10.3IFNG, TNF
336q terminal deletion syndrome10.3IL4, TNF
34corneal intraepithelial neoplasm10.3IFNG, TNF
35basidiobolomycosis10.3IL4, TNF
36reproductive system disease10.3IFNG, TNF
37paralytic lagophthalmos10.3IL4, TNF
38progressive relapsing multiple sclerosis10.3IFNG, IL4
39cutaneous porphyria10.3IFNG, TNF
40spondylolysis10.3IFNG, TNF
41rhizomelic chondrodysplasia punctata10.2IFNG, TNF
42neurotic excoriation10.2IL4, TNF
43peripheral t-cell lymphoma10.2IL4, TNF
44burn scar10.2IFNG, TNF
45alkhurma hemorrhagic fever10.2IL4, TNF
46peanut allergy10.2IL4, TNF
47gait apraxia10.2IL4, TNF
48dentinogenesis imperfecta10.2IFNG, TNF
49inner ear disease10.2IFNG, TNF
50senile cataract10.2IL4, TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to autoimmune myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

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MGI Mouse Phenotypes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

41 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.6IFNG, IL4, SPP1, TNF
2MP:00053678.5IFNG, IL4, PPARG, SPP1
3MP:00053908.3IFNG, IL4, PPARG, SPP1, TNF
4MP:00107718.2IFNG, IL4, PPARG, SPP1, TNF
5MP:00053798.1IFNG, IL2, IL4, PPARG, TNF
6MP:00030128.0IFNG, IL2, IL4, PPARG, TNF
7MP:00020068.0IFNG, IL2, PPARG, SPP1, TNF
8MP:00053888.0IFNG, IL2, IL4, SPP1, TNF
9MP:00053897.5IFNG, IL2, IL4, PPARG, SPP1, TNF
10MP:00053707.5IFNG, IL2, IL4, PPARG, SPP1, TNF
11MP:00053847.4IFNG, IL2, IL4, PPARG, SPP1, TNF
12MP:00053857.3IFNG, IL2, PPARG, SPP1, TNF
13MP:00053877.3IFNG, IL2, IL4, PPARG, SPP1, TNF
14MP:00053977.2IFNG, IL2, IL4, PPARG, SPP1, TNF
15MP:00107687.2IFNG, IL2, IL4, PPARG, SPP1, TNF
16MP:00053787.1IFNG, IL2, IL4, PPARG, SPP1, TNF
17MP:00053767.0IFNG, IL2, IL4, PPARG, SPP1, TNF

Drugs & Therapeutics for Autoimmune Myocarditis

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Drugs for Autoimmune Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Certolizumab pegolapproved122428863-50-7
Synonyms:
428863-50-7
CDP870
Certolizumab pegol
 
Certolizumab pegol (USAN/INN)
Certolizumab pegol (genetical recombination)
Certolizumab pegol (genetical recombination) (JAN)
D03441
cimzia
2
Etanerceptapproved, investigational397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
3
Infliximabapproved378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
4
Adalimumabapproved478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
5Immunosuppressive Agents12770
6Gastrointestinal Agents8109
7Dermatologic Agents5674
8Anti-Inflammatory Agents10355
9Antirheumatic Agents10627

Interventional clinical trials:

idNameStatusNCT IDPhase
1Myocardial Screening in Fetuses With Congenital Cytomegalovirus (CMV) InfectionNot yet recruitingNCT02787382Phase 3
2Myocardial Inflammation in Systemic Lupus ErythematosusUnknown statusNCT01761422
3RHYTHM (Formerly Escape II Myocardium)RecruitingNCT01548768

Search NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

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Anatomical Context for Autoimmune Myocarditis

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MalaCards organs/tissues related to Autoimmune Myocarditis:

36
T cells, Heart, B cells, Bone, Monocytes, Lung, Thymus

Publications for Autoimmune Myocarditis

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Articles related to Autoimmune Myocarditis:

(show top 50)    (show all 363)
idTitleAuthorsYear
1
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. (27922195)
2017
2
Recent advances in the management of autoimmune myocarditis: insights from animal studies. (26696255)
2016
3
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. (27342875)
2016
4
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. (26621778)
2016
5
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. (27501378)
2016
6
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. (27440853)
2016
7
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. (27502060)
2016
8
Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice. (27818491)
2016
9
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. (27615269)
2016
10
Cacao polyphenols ameliorate autoimmune myocarditis in mice. (26657007)
2016
11
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. (27184135)
2016
12
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. (27390159)
2016
13
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. (26696258)
2016
14
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. (26658748)
2016
15
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. (26772776)
2016
16
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. (26899795)
2016
17
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. (27099262)
2016
18
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. (27044832)
2016
19
Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM). (27501319)
2016
20
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. (26660726)
2016
21
Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. (27052830)
2016
22
Fenofibrate treatment of rats with experimental autoimmune myocarditis by alleviating Treg/Th17 disorder. (27095924)
2016
23
FTY720 (Gilenya) treatment prevents spontaneous autoimmune myocarditis and dilated cardiomyopathy in transgenic HLA-DQ8-BALB/c mice. (27288745)
2016
24
Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats. (26946470)
2016
25
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma. (25901283)
2015
26
Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS. (26768489)
2015
27
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. (26475067)
2015
28
A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice. (25768281)
2015
29
Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis. (25596465)
2015
30
Anti-inflammatory Role of Obestatin in Autoimmune myocarditis. (26426263)
2015
31
Localization of CD8 T cell epitope within cardiac myosin heavy chain-I+334-352 that induces autoimmune myocarditis in A/J mice. (26422020)
2015
32
Mouse Models of Autoimmune Diseases - Autoimmune Myocarditis. (25777763)
2015
33
Intravital microscopy -A novel toolin characterizing congestive heart failurein experimental autoimmune myocarditis. (26484717)
2015
34
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice. (24447632)
2014
35
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease. (25191648)
2014
36
Preclinical Validation of 99mTc-Annexin A5-128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with 99mTc-HYNIC-Annexin A5. (25431156)
2014
37
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse. (24998332)
2014
38
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis. (24189626)
2014
39
Mortality and Morbidity in Different Immunization Protocols for Experimental Autoimmune Myocarditis in Rats. (24410878)
2014
40
Experimental drugs for treatment of autoimmune myocarditis. (25146626)
2014
41
Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy. (25551279)
2014
42
N-Acetylcysteine Ameliorates Experimental Autoimmune Myocarditis in Rats via Nitric Oxide. (25147347)
2014
43
Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. (24205804)
2014
44
Tenascin-C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation. (25376187)
2014
45
Attenuation of Experimental Autoimmune Myocarditis by si-RNA Mediated CD40 Silencing. (25297507)
2014
46
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis. (24269624)
2014
47
A P2X7 receptor antagonist attenuates experimental autoimmune myocarditis via suppressed myocardial CD4(+) T and macrophage infiltration and NADPH oxidase 2/4 expression in mice. (24879505)
2014
48
Blocking the receptor for advanced glycation end product activation attenuates autoimmune myocarditis. (24599045)
2014
49
Oleanolic acid modulates the immune-inflammatory response in mice with experimental autoimmune myocarditis and protects from cardiac injury. Therapeutic implications for the human disease. (24732212)
2014
50
Periodontal bacteria aggravate experimental autoimmune myocarditis in mice. (23262138)
2013

Variations for Autoimmune Myocarditis

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Expression for genes affiliated with Autoimmune Myocarditis

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Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for genes affiliated with Autoimmune Myocarditis

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Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathwaysScoreTop Affiliating Genes
19.5IFNG, TNF
2
Show member pathways
9.5IFNG, TNF
39.5IFNG, TNF
49.5IFNG, TNF
59.2IFNG, IL2
69.1IFNG, PPARG, TNF
7
Show member pathways
9.0IFNG, IL4, TNF
8
Show member pathways
9.0IFNG, IL4, TNF
98.9IFNG, SPP1, TNF
108.9IFNG, SPP1, TNF
11
Show member pathways
8.7IFNG, IL2, TNF
128.7IFNG, IL2, TNF
138.7IFNG, IL2, TNF
14
Show member pathways
8.7IFNG, IL2, TNF
15
Show member pathways
8.7IFNG, IL2, TNF
16
Show member pathways
8.7IFNG, IL2, TNF
17
Show member pathways
8.7IFNG, IL2, IL4
18
Show member pathways
8.7IFNG, IL2, IL4
198.7IFNG, IL2, IL4
208.7IFNG, IL2, IL4
218.7IFNG, IL2, IL4
228.7IFNG, IL2, IL4
238.6IL2, IL4, TNF
248.5IL2, IL4, SPP1
25
Show member pathways
8.2IFNG, IL2, IL4, TNF
268.2IFNG, IL2, IL4, TNF
278.2IFNG, IL2, IL4, TNF
288.2IFNG, IL2, IL4, TNF
29
Show member pathways
8.2IFNG, IL2, IL4, TNF
30
Show member pathways
8.2IFNG, IL2, IL4, TNF
318.2IFNG, IL2, IL4, TNF
32
Show member pathways
8.2IFNG, IL2, IL4, TNF
33
Show member pathways
8.2IFNG, IL2, IL4, TNF
34
Show member pathways
8.2IFNG, IL2, IL4, TNF
358.2IFNG, IL2, IL4, TNF
36
Show member pathways
8.1IFNG, IL2, SPP1, TNF
37
Show member pathways
7.7IFNG, IL2, IL4, PPARG, TNF
38
Show member pathways
7.6IFNG, IL2, IL4, SPP1, TNF

GO Terms for genes affiliated with Autoimmune Myocarditis

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Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7IFNG, IL4, TNF
2extracellular spaceGO:00056157.6IFNG, IL2, IL4, SPP1, TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of smooth muscle cell proliferationGO:004866210.4IFNG, PPARG
2extrinsic apoptotic signaling pathwayGO:009719110.3IFNG, TNF
3defense response to protozoanGO:004283210.3IFNG, IL4
4humoral immune responseGO:000695910.3IFNG, TNF
5negative regulation of growth of symbiont in hostGO:004413010.3IFNG, TNF
6positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IFNG, TNF
7positive regulation of cell adhesionGO:004578510.3IFNG, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IFNG, TNF
9positive regulation of nitric oxide biosynthetic processGO:004542910.3IFNG, TNF
10positive regulation of osteoclast differentiationGO:004567210.3IFNG, TNF
11positive regulation of MHC class II biosynthetic processGO:004534810.3IFNG, IL4
12negative regulation of acute inflammatory responseGO:000267410.3IL4, PPARG
13positive regulation of vitamin D biosynthetic processGO:006055710.2IFNG, TNF
14protein import into nucleus, translocationGO:000006010.2IFNG, TNF
15positive regulation of mononuclear cell migrationGO:007167710.2IL4, TNF
16extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.9IL2, IL4
17positive regulation of activated T cell proliferationGO:00421049.9IL2, IL4
18positive regulation of B cell proliferationGO:00308909.9IL2, IL4
19positive regulation of interferon-gamma productionGO:00327299.9IL2, TNF
20positive regulation of T cell differentiationGO:00455829.9IL2, IL4
21positive regulation of apoptotic processGO:00430659.8IFNG, PPARG, TNF
22positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.8IL2, IL4
23positive regulation of chemokine biosynthetic processGO:00450809.8IFNG, IL4, TNF
24positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL4, PPARG, TNF
25response to drugGO:00424939.6IFNG, IL4, PPARG
26positive regulation of isotype switching to IgG isotypesGO:00483049.5IFNG, IL2, IL4
27positive regulation of T cell proliferationGO:00421029.5IFNG, IL2, IL4
28positive regulation of protein phosphorylationGO:00019349.4IL2, IL4, TNF
29positive regulation of transcription, DNA-templatedGO:00458939.2IFNG, IL4, PPARG, TNF
30response to organic substanceGO:00100338.9PPARG, SPP1, TNF
31positive regulation of transcription from RNA polymerase II promoterGO:00459448.4IFNG, IL2, IL4, PPARG, TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051257.6IFNG, IL2, IL4, SPP1, TNF

Sources for Autoimmune Myocarditis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet