MCID: ATM023
MIFTS: 17

Autoimmune Oophoritis

Categories: Rare diseases

Aliases & Classifications for Autoimmune Oophoritis

MalaCards integrated aliases for Autoimmune Oophoritis:

Name: Autoimmune Oophoritis 49 69

Classifications:



External Ids:

UMLS 69 C0878654

Summaries for Autoimmune Oophoritis

NIH Rare Diseases : 49 Autoimmune oophoritis is a rare cause of primary ovarian insufficiency (POI). It happens when the body's immune system mistakenly attacks the ovaries causing inflammation, atrophy and fibrosis. These changes stop the ovaries from working normally.  The main symptoms of autoimmune oophorotis are irregular or absent menstrual period (amenorrhea) and symptoms related to ovarian cysts such as abdominal cramping, bloating, nausea and vomiting. Autoimmune oophoritis may occur as part of autoimmune polyglandular syndrome type I and type II but has also been associated with lupus, pernicious anemia, myasthenia gravis and other autoimmune conditions. The underlying cause of autoimmune oophoritis is unknown. Diagnosis involves a special blood test which looks for anti-steroid or anti-ovarian antibodies, a pelvic ultrasound to look for enlarged cystic ovaries and tests to rule out other possible causes of POI. Management of autoimmune oophoritis involves emotional support, possible estrogen replacement therapy and management of other autoimmune conditions. Last updated: 6/6/2016

MalaCards based summary : Autoimmune Oophoritis is related to alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity and premature ovarian failure 1. The drugs Prednisone and glucocorticoids have been mentioned in the context of this disorder. Affiliated tissues include ovary, testes and t cells.

Related Diseases for Autoimmune Oophoritis

Diseases related to Autoimmune Oophoritis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
2 premature ovarian failure 1 10.0
3 blood group, i system 9.8
4 myasthenia gravis 9.8
5 premature menopause 9.8
6 gastritis 9.8
7 infertility 9.8
8 myasthenia gravis congenital 9.8

Graphical network of the top 20 diseases related to Autoimmune Oophoritis:



Diseases related to Autoimmune Oophoritis

Symptoms & Phenotypes for Autoimmune Oophoritis

Drugs & Therapeutics for Autoimmune Oophoritis

Drugs for Autoimmune Oophoritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved 53-03-2 5865
2 glucocorticoids
3 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Steroid Therapy in Autoimmune Premature Ovarian Failure Completed NCT00001306
2 Ovarian Histopathology and Laparoscopic Assessment of Premature Ovarian Failure Not yet recruiting NCT03412487

Search NIH Clinical Center for Autoimmune Oophoritis

Genetic Tests for Autoimmune Oophoritis

Anatomical Context for Autoimmune Oophoritis

MalaCards organs/tissues related to Autoimmune Oophoritis:

38
Ovary, Testes, T Cells

Publications for Autoimmune Oophoritis

Articles related to Autoimmune Oophoritis:

(show all 38)
# Title Authors Year
1
Autoimmune oophoritis: A rarely encountered ovarian lesion. ( 25885148 )
2015
2
Resolution of autoimmune oophoritis after thymectomy in a myasthenia gravis patient. ( 22155465 )
2011
3
Autoimmune oophoritis with multiple molecular targets mitigated by transgenic expression of mater. ( 21447630 )
2011
4
Local lymphocytic and epithelial activation in a case of autoimmune oophoritis. ( 18054927 )
2008
5
High serum inhibin concentration discriminates autoimmune oophoritis from other forms of primary ovarian insufficiency. ( 18211971 )
2008
6
Autoimmune oophoritis in the adolescent. ( 18574216 )
2008
7
Effect of alpha-melanotropin hormone on serum levels of luteinizing hormone and progesterone in experimental rat autoimmune oophoritis. ( 16716456 )
2006
8
Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. ( 16213850 )
2005
9
Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels. ( 15705922 )
2005
10
Effects of alpha-MSH on progesterone and nitric oxide release by cultured ovarian granulosa cells in experimental rat autoimmune oophoritis. ( 12222744 )
2002
11
Post-thymectomy murine experimental autoimmune oophoritis is associated with reduced natural killer cell activity. ( 9352028 )
1997
12
Murine postthymectomy autoimmune oophoritis develops in association with a persistent neonatal-like Th2 response. ( 9175911 )
1997
13
ZP3 peptide vaccine that induces antibody and reversible infertility without autoimmune oophoritis. ( 8962644 )
1996
14
Susceptibility to murine experimental autoimmune oophoritis is associated with genes outside the major histocompatibility complex (MHC). ( 8862255 )
1996
15
Anamnestic development of lymphocytic infiltration in murine experimental autoimmune oophoritis is primarily localized in the stroma and theca. ( 8526989 )
1995
16
Altered target organ. A mechanism of postrecovery resistance to murine autoimmune oophoritis. ( 7561067 )
1995
17
Murine experimental autoimmune oophoritis develops independently of gonadotropin stimulation and is primarily localized in the stroma and theca. ( 8526990 )
1995
18
Interspecies-specific ovarian autoantigens involved in neonatal thymectomy-induced murine autoimmune oophoritis. ( 7691072 )
1993
19
Eosinophilic perifolliculitis: a variant of autoimmune oophoritis? ( 8253554 )
1993
20
Autoimmune oophoritis. An incidental finding. ( 8351251 )
1993
21
Autoimmune oophoritis--a case report. ( 1285930 )
1992
22
Autoimmune oophoritis associated with polycystic ovaries. ( 1916689 )
1991
23
Effector and regulatory cells in autoimmune oophoritis elicited by neonatal thymectomy. ( 1717580 )
1991
24
Experimental autoimmune oophoritis. II. Both lymphoid cells and antibodies are successful in adoptive transfer. ( 1777554 )
1991
25
Neonatal thymectomy affects follicle populations before the onset of autoimmune oophoritis in B6A mice. ( 2182841 )
1990
26
Plasma protein and hormone profiles associated with autoimmune oophoritis and ovarian tumorigenesis in neonatally thymectomized mice. ( 2129762 )
1990
27
Experimental autoimmune oophoritis. I. Inhibition of fertility in rats isoimmunized with homogenates of ovary. ( 2818819 )
1989
28
Cystic ovarian enlargement resulting from autoimmune oophoritis. ( 2761940 )
1989
29
Acute oocyte loss in experimental autoimmune oophoritis as a possible model of premature ovarian failure. ( 3337168 )
1988
30
Premature menopause associated with autoimmune oophoritis. Case report. ( 3390409 )
1988
31
Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Autoantibodies. ( 3826296 )
1987
32
Persistent progesterone production associated with autoimmune oophoritis. A case report. ( 3585875 )
1987
33
Lymphocyte dysfunction in autoimmune oophoritis. Resumption of menses with corticosteroids. ( 3740091 )
1986
34
Autoimmune oophoritis. ( 6691297 )
1984
35
Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. ( 6983557 )
1982
36
Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. ( 6983558 )
1982
37
Autoimmune oophoritis in thymectomized mice: T cell requirement in adoptive cell transfer. ( 6970639 )
1980
38
Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes. ( 6998618 )
1980

Variations for Autoimmune Oophoritis

Expression for Autoimmune Oophoritis

Search GEO for disease gene expression data for Autoimmune Oophoritis.

Pathways for Autoimmune Oophoritis

GO Terms for Autoimmune Oophoritis

Sources for Autoimmune Oophoritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
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53 OMIM
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58 PubMed
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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