APS2
MCID: ATM025
MIFTS: 27

Autoimmune Polyglandular Syndrome Type 2 (APS2) malady

Rare diseases category

Summaries for Autoimmune Polyglandular Syndrome Type 2

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44NIH Rare Diseases, 34MalaCards
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NIH Rare Diseases:44 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 3/24/2010

MalaCards: Autoimmune Polyglandular Syndrome Type 2, also known as multiple endocrine deficiency syndrome, type 2, is related to type 1 diabetes mellitus and diabetes mellitus. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Allograft rejection. The compounds cholesterol and hydrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and ovary.

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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44NIH Rare Diseases, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

autoimmune polyglandular syndrome type 2 44
multiple endocrine deficiency syndrome, type 2 44
diabetes mellitus, addison's disease, myxedema 44
polyglandular autoimmune syndrome, type 2 44
autoimmune syndrome type ii polyglandular 46
autoimmune polyendocrine syndrome type 2 44
polyglandular deficiency syndrome type 2 44
schmidt's syndrome 44
schmidt syndrome 44
pga 2 44
aps2 44


Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Symptoms for Autoimmune Polyglandular Syndrome Type 2

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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34MalaCards
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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

34
Thyroid, Brain, Ovary

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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Publications for Autoimmune Polyglandular Syndrome Type 2

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53PubMed
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Articles related to Autoimmune Polyglandular Syndrome Type 2:

(show all 16)
idTitleAuthorsYear
1
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. (22677116)
2013
2
Brain imaging in cerebellar ataxia associated with autoimmune polyglandular syndrome type 2. (21091821)
2012
3
You're the flight surgeon: autoimmune polyglandular syndrome type 2. (22873000)
2012
4
Coexistence of autoimmune polyglandular syndrome type 2 and diabetes insipidus in pregnancy. (22033074)
2011
5
Autoimmune polyglandular syndrome type 2 induced by treatment with interferon alpha. (21412133)
2011
6
Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes. (21388354)
2011
7
Autoimmune polyglandular syndrome type 2: an unusual presentation. (21137658)
2010
8
Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis. (19901721)
2009
9
From macrocytosis to incomplete autoimmune polyglandular syndrome type 2: a poorly known entity. (18205764)
2008
10
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2. (17558682)
2007
11
Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? (15270837)
2004
12
Assessment of adrenocortical function and autoantibodies in a baby born to a mother with autoimmune polyglandular syndrome Type 2. (15505983)
2004
13
Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2). (15216452)
2004
14
Autoimmune polyglandular syndrome type 2 and osteoporosis in a 69 years old patient]. (16737004)
2003
15
Type 1 diabetes mellitus masked by primary adrenal insufficiency in a child with autoimmune polyglandular syndrome type 2. (12635986)
2003
16
Coexistence of common variable immunodeficiency and autoimmune polyglandular syndrome type 2. (11393580)
2001

Variations for Autoimmune Polyglandular Syndrome Type 2

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cholesterol46 30 25 1212.0GAD2, INS
2hydrogen46 2510.0GAD2, ATP5O
3c-peptide468.9GAD2, INS

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Products for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Polyglandular Syndrome Type 2

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet