MCID: ATM025
MIFTS: 20

Autoimmune Polyglandular Syndrome Type 2 malady

Category: Rare diseases

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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Aliases & Descriptions for Autoimmune Polyglandular Syndrome Type 2:

Name: Autoimmune Polyglandular Syndrome Type 2 45
Multiple Endocrine Deficiency Syndrome, Type 2 45
Diabetes Mellitus, Addison's Disease, Myxedema 45
Autoimmune Syndrome Type Ii, Polyglandular 65
Autoimmune Syndrome Type Ii Polyglandular 47
Polyglandular Autoimmune Syndrome, Type 2 45
 
Autoimmune Polyendocrine Syndrome Type 2 45
Polyglandular Deficiency Syndrome Type 2 45
Schmidt's Syndrome 45
Schmidt Syndrome 45
Pga 2 45
Aps2 45

Classifications:



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UMLS65 C0085860

Summaries for Autoimmune Polyglandular Syndrome Type 2

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NIH Rare Diseases:45 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 12/28/2015

MalaCards based summary: Autoimmune Polyglandular Syndrome Type 2, also known as multiple endocrine deficiency syndrome, type 2, is related to hyperglycemia and autoimmune polyendocrine syndrome type 2. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (Glutamate Decarboxylase 2), and among its related pathways is Alzheimers disease. Affiliated tissues include thyroid, bone and lung.

Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Symptoms for Autoimmune Polyglandular Syndrome Type 2

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Autoimmune Polyglandular Syndrome Type 2

Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

33
Thyroid, Bone, Lung, Prostate, Endothelial

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Polyglandular Syndrome Type 2:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Autoimmune Polyglandular Syndrome Type 2

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Articles related to Autoimmune Polyglandular Syndrome Type 2:

(show all 22)
idTitleAuthorsYear
1
Treatment of ulcerative colitis. (24285003)
2014
2
Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing I^-human chorionic gonadotropin. (24362936)
2013
3
The efficacy and safety of modified Snyder-Thompson posterior scleral reinforcement in extensive high myopia of Chinese children. (23907482)
2013
4
Update on risk factors for food allergy. (22464642)
2012
5
Expression of cytokine IL-1I+ and S100I^ in different types of plaques in Alzheimer's disease]. (22177239)
2011
6
NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation. (19901266)
2010
7
Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer]. (17584637)
2007
8
Cerebral nocardiosis in a patient with NHL treated with rituximab. (17696199)
2007
9
Therapeutic modalities in hepatitis C: challenges and development. (15655043)
2005
10
Transferrin receptor 2 protein is not expressed in normal erythroid cells. (15084147)
2004
11
Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells. (15219377)
2004
12
Identification of mouse and human macrophages as a site of synthesis of hepatic lipase. (11971936)
2002
13
Transferrin receptor-2 gene and non-C282Y homozygous patients with hemochromatosis. (11358390)
2001
14
Antileukotrienes in asthma: present situation. (11336598)
2001
15
Marin-Amat syndrome: case report and review of the literature. (10334404)
1999
16
The two-state process of the heat shock protein 90 thermal denaturation: effect of calcium and magnesium. (9705856)
1998
17
Interleukin-1 receptor antagonist blocks interleukin-1-induced expression of cyclooxygenase-2 in endometrium. (9322624)
1997
18
Cytochrome P450 2D6 and glutathione S-transferase genotype in sudden infant death syndrome. (9069041)
1997
19
RB protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. (8058306)
1994
20
Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH. (1733973)
1992
21
Extrapulmonary tuberculosis: experience at Veterans General Hospital-Taipei, 1985 to 1987. (1686884)
1991
22
Prostate cancer in a 75-year-old man after four decades of testicular androgen deprivation. (1743239)
1991

Variations for Autoimmune Polyglandular Syndrome Type 2

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Search GEO for disease gene expression data for Autoimmune Polyglandular Syndrome Type 2.

Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Pathways related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.1ATP5O, INS

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Sources for Autoimmune Polyglandular Syndrome Type 2

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet