APS2
MCID: ATM025
MIFTS: 27

Autoimmune Polyglandular Syndrome Type 2 (APS2) malady

Rare diseases category
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Summaries for Autoimmune Polyglandular Syndrome Type 2

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 3/24/2010

MalaCards: Autoimmune Polyglandular Syndrome Type 2, also known as multiple endocrine deficiency syndrome, type 2, is related to type 1 diabetes mellitus and diabetes mellitus. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Allograft rejection. The compounds cholesterol and hydrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, brain and ovary.

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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43NIH Rare Diseases, 45Novoseek
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Classifications:

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Global: Rare diseases


Aliases & Descriptions:

autoimmune polyglandular syndrome type 2 43
multiple endocrine deficiency syndrome, type 2 43
diabetes mellitus, addison's disease, myxedema 43
polyglandular autoimmune syndrome, type 2 43
autoimmune syndrome type ii polyglandular 45
autoimmune polyendocrine syndrome type 2 43
polyglandular deficiency syndrome type 2 43
schmidt's syndrome 43
schmidt syndrome 43
pga 2 43
aps2 43


Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Symptoms for Autoimmune Polyglandular Syndrome Type 2

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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33MalaCards
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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

33
Thyroid, Brain, Ovary

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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Publications for Autoimmune Polyglandular Syndrome Type 2

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52PubMed
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Articles related to Autoimmune Polyglandular Syndrome Type 2:

(show all 16)
idTitleAuthorsYear
1
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. (22677116)
2013
2
Brain imaging in cerebellar ataxia associated with autoimmune polyglandular syndrome type 2. (21091821)
2012
3
You're the flight surgeon: autoimmune polyglandular syndrome type 2. (22873000)
2012
4
Coexistence of autoimmune polyglandular syndrome type 2 and diabetes insipidus in pregnancy. (22033074)
2011
5
Autoimmune polyglandular syndrome type 2 induced by treatment with interferon alpha. (21412133)
2011
6
Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes. (21388354)
2011
7
Autoimmune polyglandular syndrome type 2: an unusual presentation. (21137658)
2010
8
Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis. (19901721)
2009
9
From macrocytosis to incomplete autoimmune polyglandular syndrome type 2: a poorly known entity. (18205764)
2008
10
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2. (17558682)
2007
11
Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? (15270837)
2004
12
Assessment of adrenocortical function and autoantibodies in a baby born to a mother with autoimmune polyglandular syndrome Type 2. (15505983)
2004
13
Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2). (15216452)
2004
14
Autoimmune polyglandular syndrome type 2 and osteoporosis in a 69 years old patient]. (16737004)
2003
15
Type 1 diabetes mellitus masked by primary adrenal insufficiency in a child with autoimmune polyglandular syndrome type 2. (12635986)
2003
16
Coexistence of common variable immunodeficiency and autoimmune polyglandular syndrome type 2. (11393580)
2001

Variations for Autoimmune Polyglandular Syndrome Type 2

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 5Cell Signaling Technology
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Compounds for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cholesterol45 29 24 1112.0GAD2, INS
2hydrogen45 2410.0GAD2, ATP5O
3c-peptide458.9GAD2, INS

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Products for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Polyglandular Syndrome Type 2

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet