MCID: ATM025
MIFTS: 21

Autoimmune Polyglandular Syndrome Type 2 malady

Rare diseases category

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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Sources:
45NIH Rare Diseases, 47Novoseek, 65UMLS
See all sources

Aliases & Descriptions for Autoimmune Polyglandular Syndrome Type 2:

Name: Autoimmune Polyglandular Syndrome Type 2 45
Multiple Endocrine Deficiency Syndrome, Type 2 45
Diabetes Mellitus, Addison's Disease, Myxedema 45
Autoimmune Syndrome Type Ii, Polyglandular 65
Autoimmune Syndrome Type Ii Polyglandular 47
Polyglandular Autoimmune Syndrome, Type 2 45
 
Autoimmune Polyendocrine Syndrome Type 2 45
Polyglandular Deficiency Syndrome Type 2 45
Schmidt's Syndrome 45
Schmidt Syndrome 45
Pga 2 45
Aps2 45


Classifications:



Summaries for Autoimmune Polyglandular Syndrome Type 2

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NIH Rare Diseases:45 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 3/24/2010

MalaCards based summary: Autoimmune Polyglandular Syndrome Type 2, also known as multiple endocrine deficiency syndrome, type 2, is related to autoimmune polyendocrine syndrome type 2 and autoimmune polyendocrine syndrome. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (Glutamate Decarboxylase 2 (Pancreatic Islets And Brain, 65kDa)), and among its related pathways are Alzheimers disease and Glucose / Energy Metabolism. Affiliated tissues include thyroid, ovary and brain.

Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Symptoms for Autoimmune Polyglandular Syndrome Type 2

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Safety of and Immune Response to a Prime-Boost Vaccine Regimen in HIV-Uninfected Vaccine-Naive AdultsCompletedNCT00820846Phase 2
2Safety of and Immune Response to a DNA HIV Vaccine (pGA2/JS7) Boosted With a Modified Vaccinia HIV Vaccine (MVA/HIV62) in Healthy AdultsCompletedNCT00301184Phase 1
3Safety of an HIV DNA Vaccine Given to HIV Uninfected AdultsCompletedNCT00043511Phase 1
4A Safety and Immunogenicity Study of a Plasmid DNA Prime and MVA Boost Vaccine in HIV-1 Infected Adults on ARTCompletedNCT01378156Phase 1

Search NIH Clinical Center for Autoimmune Polyglandular Syndrome Type 2

Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

33
Thyroid, Ovary, Brain

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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Publications for Autoimmune Polyglandular Syndrome Type 2

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Articles related to Autoimmune Polyglandular Syndrome Type 2:

(show all 22)
idTitleAuthorsYear
1
Autoimmune polyglandular syndrome type 2: a rare condition in childhood. (25800482)
2015
2
Hyponatremic rhabdomyolysis in Addison's disease in a child with autoimmune polyglandular syndrome type 2. (26300496)
2015
3
Addison's disease in a patient with hypothyroidism: autoimmune polyglandular syndrome type 2. (26240101)
2015
4
Autoimmune polyglandular syndrome type 2 manifested as Hashimoto's thyroiditis and adrenocortical insufficiency, in Turner syndrome woman, with onset following introduction of treatment with recombinant human growth hormone. (26071578)
2015
5
Anti-inflammatory effects of bromocriptine in a patient with autoimmune polyglandular syndrome type 2. (24977964)
2014
6
Precocious presentation of autoimmune polyglandular syndrome type 2 associated with an AIRE mutation. (25402387)
2014
7
Autoimmune polyglandular syndrome type 2, alopecia universalis and Crohn's disease. (22677116)
2013
8
Brain imaging in cerebellar ataxia associated with autoimmune polyglandular syndrome type 2. (21091821)
2012
9
You're the flight surgeon: autoimmune polyglandular syndrome type 2. (22873000)
2012
10
Coexistence of autoimmune polyglandular syndrome type 2 and diabetes insipidus in pregnancy. (22033074)
2011
11
Autoimmune polyglandular syndrome type 2 induced by treatment with interferon alpha. (21412133)
2011
12
Autoimmune polyglandular syndrome type 2 shows the same HLA class II pattern as type 1 diabetes. (21388354)
2011
13
Autoimmune polyglandular syndrome type 2: an unusual presentation. (21137658)
2010
14
Autoimmune polyglandular syndrome type 2 with myasthenia gravis crisis. (19901721)
2009
15
From macrocytosis to incomplete autoimmune polyglandular syndrome type 2: a poorly known entity. (18205764)
2008
16
A patient with combined polycystic ovary syndrome and autoimmune polyglandular syndrome type 2. (17558682)
2007
17
Autoimmune polyglandular syndrome Type 2: the tip of an iceberg? (15270837)
2004
18
Assessment of adrenocortical function and autoantibodies in a baby born to a mother with autoimmune polyglandular syndrome Type 2. (15505983)
2004
19
Pregnancy in a woman suffering from type 1 diabetes associated with Addison's disease and Hashimoto's thyroiditis (fully developed Autoimmune Polyglandular Syndrome Type 2). (15216452)
2004
20
Autoimmune polyglandular syndrome type 2 and osteoporosis in a 69 years old patient]. (16737004)
2003
21
Type 1 diabetes mellitus masked by primary adrenal insufficiency in a child with autoimmune polyglandular syndrome type 2. (12635986)
2003
22
Coexistence of common variable immunodeficiency and autoimmune polyglandular syndrome type 2. (11393580)
2001

Variations for Autoimmune Polyglandular Syndrome Type 2

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Search GEO for disease gene expression data for Autoimmune Polyglandular Syndrome Type 2.

Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Pathways related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ATP5O, INS
29.0GAD2, INS

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Sources for Autoimmune Polyglandular Syndrome Type 2

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet