APS2
MCID: ATM025
MIFTS: 16

Autoimmune Polyglandular Syndrome Type 2 (APS2) malady

Summaries for Autoimmune Polyglandular Syndrome Type 2

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 3/24/2010

MalaCards: Autoimmune Polyglandular Syndrome Type 2, also known as diabetes mellitus, addison's disease, myxedema, is related to polycystic ovary syndrome and cerebellar ataxia. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)), and among its related pathways are Glucose / Energy Metabolism and Allograft rejection. The compound c-peptide have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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42NIH Rare Diseases, 44Novoseek
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Aliases & Descriptions:

autoimmune polyglandular syndrome type 2 42
diabetes mellitus, addison's disease, myxedema 42
multiple endocrine deficiency syndrome, type 2 42
autoimmune syndrome type ii polyglandular 44
autoimmune polyendocrine syndrome type 2 42
pga 2 42
aps2 42


Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Clinical Features for Autoimmune Polyglandular Syndrome Type 2

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Autoimmune Polyglandular Syndrome Type 2

Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

32
Thyroid

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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Publications for Autoimmune Polyglandular Syndrome Type 2

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Genetic Variations for Autoimmune Polyglandular Syndrome Type 2

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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4Cell Signaling Technology, 29KEGG
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Pathways related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0INS, GAD2
2
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9.0INS, GAD2

Compounds for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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44Novoseek
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Compounds related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1c-peptide449.0INS, GAD2

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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Products for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Polyglandular Syndrome Type 2

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet