APS2
MCID: ATM025
MIFTS: 15

Autoimmune Polyglandular Syndrome Type 2 (APS2) malady

Summaries for Autoimmune Polyglandular Syndrome Type 2

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Autoimmune polyglandular syndrome type 2 is an autoimmune disorder that affects many hormone-producing (endocrine) glands. this condition is characterized by the presence of addison's disease along with autoimmune thyroid disease and/or type 1 diabetes. affected individuals may also have problems with other endocrine glands. autoimmune polyglandular syndrome type 2 is diagnosed in adulthood, typically around age 30. this condition occurs more often in women than men, and treatment primarily involves hormone replacement therapy. the cause of autoimmune polyglandular syndrome type 2 is unknown, although it may involve a combination of genetic and environmental factors. last updated: 3/24/2010

MalaCards: Autoimmune Polyglandular Syndrome Type 2, also known as diabetes mellitus, addison's disease, myxedema, is related to polycystic ovary syndrome and thyroiditis. An important gene associated with Autoimmune Polyglandular Syndrome Type 2 is GAD2 (glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)), and among its related pathways are Glucose / Energy Metabolism and Allograft rejection. The compound c-peptide have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 2

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43NIH Rare Diseases, 45Novoseek
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Aliases & Descriptions:

autoimmune polyglandular syndrome type 2 43
diabetes mellitus, addison's disease, myxedema 43
multiple endocrine deficiency syndrome, type 2 43
autoimmune syndrome type ii polyglandular 45
autoimmune polyendocrine syndrome type 2 43
pga 2 43
aps2 43


Related Diseases for Autoimmune Polyglandular Syndrome Type 2

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 2:



Diseases related to autoimmune polyglandular syndrome type 2

Clinical Features for Autoimmune Polyglandular Syndrome Type 2

Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 2

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Autoimmune Polyglandular Syndrome Type 2

Anatomical Context for Autoimmune Polyglandular Syndrome Type 2

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33MalaCards
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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 2:

33
Thyroid

Animal Models for Autoimmune Polyglandular Syndrome Type 2 or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Autoimmune Polyglandular Syndrome Type 2

Genetic Variations for Autoimmune Polyglandular Syndrome Type 2

Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

Search GEO for disease gene expression data for Autoimmune Polyglandular Syndrome Type 2.

Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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4Cell Signaling Technology, 30KEGG
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Pathways related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0INS, GAD2
2
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9.0INS, GAD2

Compounds for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

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45Novoseek
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Compounds related to Autoimmune Polyglandular Syndrome Type 2 according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1c-peptide459.0INS, GAD2

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

Products for genes affiliated with Autoimmune Polyglandular Syndrome Type 2

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Polyglandular Syndrome Type 2

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet