MCID: ATM061
MIFTS: 19

Autoimmune Polyglandular Syndrome Type 3

Categories: Rare diseases

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 3

MalaCards integrated aliases for Autoimmune Polyglandular Syndrome Type 3:

Name: Autoimmune Polyglandular Syndrome Type 3 49
Autoimmune Polyendocrine Syndrome Type 3 49 69
Polyglandular Type Iii Autoimmune Syndrome 69
Polyglandular Autoimmune Syndrome Type 3 49
Aps3 49
Pas3 49

Classifications:



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Summaries for Autoimmune Polyglandular Syndrome Type 3

NIH Rare Diseases : 49 Autoimmune polyglandular syndrome (APS) type 3 is an autoimmune condition that affects the body's endocrine glands. The syndrome, which typically affects women during middle age, results from failure of the glands to produce their hormones. This condition is characterized by autoimmune thyroiditis along with another organ-specific autoimmune disease. The other autoimmune diseases may include diabetes mellitus, pernicious anemia, vitiligo, alopecia, myasthenia gravis, and Sjogren's syndrome. The adrenal cortex (the outer layer of the adrenal gland) is not involved. There are three types of autoimmune polyglandular syndrome type 3:  APS3A - Autoimmune thyroiditis with immune-mediated diabetes mellitus (IMDM) APS3B - Autoimmune thyroiditis with pernicious anemia APS3C - Autoimmune thyroiditis with vitiligo and/or alopecia and/or other organ-specific autoimmune disease Last updated: 1/15/2013

MalaCards based summary : Autoimmune Polyglandular Syndrome Type 3, also known as autoimmune polyendocrine syndrome type 3, is related to autoimmune polyendocrinopathy type 3 and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Polyglandular Syndrome Type 3 is CYP21A2 (Cytochrome P450 Family 21 Subfamily A Member 2). Affiliated tissues include thyroid, adrenal cortex and adrenal gland.

Related Diseases for Autoimmune Polyglandular Syndrome Type 3

Diseases related to Autoimmune Polyglandular Syndrome Type 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 autoimmune polyendocrinopathy type 3 11.2
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
3 alopecia 10.1
4 hypothyroidism 10.1
5 growth hormone deficiency 10.1
6 schizophrenia 9.9
7 neuronitis 9.9
8 alopecia universalis congenita 9.9
9 myasthenia gravis 9.9
10 ulcerative colitis 9.9
11 colitis 9.9
12 von willebrand's disease 9.9
13 thyroiditis 9.9
14 alopecia areata 9.9
15 myasthenia gravis congenital 9.9

Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 3:



Diseases related to Autoimmune Polyglandular Syndrome Type 3

Symptoms & Phenotypes for Autoimmune Polyglandular Syndrome Type 3

Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 3

Search Clinical Trials , NIH Clinical Center for Autoimmune Polyglandular Syndrome Type 3

Genetic Tests for Autoimmune Polyglandular Syndrome Type 3

Anatomical Context for Autoimmune Polyglandular Syndrome Type 3

MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 3:

38
Thyroid, Adrenal Cortex, Adrenal Gland, Cortex

Publications for Autoimmune Polyglandular Syndrome Type 3

Articles related to Autoimmune Polyglandular Syndrome Type 3:

(show all 13)
# Title Authors Year
1
Autoimmune polyglandular syndrome type 3 (APS-3) among patients with premature ovarian insufficiency (POI). ( 27240263 )
2016
2
Recovery from alopecia areata in a patient with autoimmune polyglandular syndrome type 3. ( 25759758 )
2015
3
Autoimmune polyglandular syndrome type 3 with anorexia. ( 23304573 )
2012
4
Clinical and genetic characteristics of autoimmune polyglandular syndrome type 3 variant in the Japanese population. ( 22466347 )
2012
5
Coexistence of growth hormone deficiency and autoimmune polyglandular syndrome type 3. ( 22635089 )
2012
6
Autoimmune polyglandular syndrome Type 3 and growth hormone deficiency. ( 19968812 )
2010
7
Genetics of the autoimmune polyglandular syndrome type 3 variant. ( 20578896 )
2010
8
Autoimmune polyglandular syndrome type 3 complicated by mineralocorticoid-responsive hyponatremia of the elderly. ( 21537439 )
2010
9
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. ( 19289325 )
2009
10
[Acquired von Willebrand's disease in the course of severe primary hypothyroidism in a patient with autoimmune polyglandular syndrome type 3]. ( 18335399 )
2008
11
Atypical autoimmune polyglandular syndrome type 3 overlapped by chronic HCV infection resulting in carcinogenesis and fatal infection. ( 18580728 )
2008
12
Acquired von Willebrand's syndrome in a patient with severe primary hypothyroidism associated with myasthenia gravis in the course of autoimmune polyglandular syndrome type 3. ( 17880463 )
2007
13
A rare case of autoimmune polyglandular syndrome type 3. ( 12951278 )
2003

Variations for Autoimmune Polyglandular Syndrome Type 3

Expression for Autoimmune Polyglandular Syndrome Type 3

Search GEO for disease gene expression data for Autoimmune Polyglandular Syndrome Type 3.

Pathways for Autoimmune Polyglandular Syndrome Type 3

GO Terms for Autoimmune Polyglandular Syndrome Type 3

Sources for Autoimmune Polyglandular Syndrome Type 3

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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