APS3
MCID: ATM061
MIFTS: 24

Autoimmune Polyglandular Syndrome Type 3 (APS3) malady

Summaries for Autoimmune Polyglandular Syndrome Type 3

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Autoimmune polyglandular syndrome (aps) type 3 is an autoimmune condition that affects the body's endocrine glands. the syndrome, which typically affects women during middle age, results from failure of the glands to produce their hormones. this condition is characterized by autoimmune thyroiditis along with another organ-specific autoimmune disease. the other autoimmune diseases may include diabetes mellitus, pernicious anemia, vitiligo, alopecia, myasthenia gravis, and sjogren's syndrome. the adrenal cortex (the outer layer of the adrenal gland) is not involved. there are three types of autoimmune polyglandular syndrome type 3:  aps3a - autoimmune thyroiditis with immune-mediated diabetes mellitus (imdm) aps3b - autoimmune thyroiditis with pernicious anemia aps3c - autoimmune thyroiditis with vitiligo and/or alopecia and/or other organ-specific autoimmune disease last updated: 1/15/2013

MalaCards: Autoimmune Polyglandular Syndrome Type 3, also known as polyglandular type iii autoimmune syndrome, is related to hypothyroidism and autoimmune thyroiditis. An important gene associated with Autoimmune Polyglandular Syndrome Type 3 is CYP21A2 (cytochrome P450, family 21, subfamily A, polypeptide 2). The compounds biotin and serine have been mentioned in the context of this disorder. Affiliated tissues include cortex, thyroid and adrenal gland.

Aliases & Classifications for Autoimmune Polyglandular Syndrome Type 3

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

autoimmune polyglandular syndrome type 3 42
polyglandular type iii autoimmune syndrome 60
autoimmune polyendocrine syndrome type 3 42
polyglandular autoimmune syndrome type 3 42
pas3 42
aps3 42


Related Diseases for Autoimmune Polyglandular Syndrome Type 3

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17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Polyglandular Syndrome Type 2 family:

autoimmune polyglandular syndrome type 3

Diseases related to Autoimmune Polyglandular Syndrome Type 3 via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1hypothyroidism30.6POMC, VWF
2autoimmune thyroiditis10.3
3von willebrand's disease10.3
4factor viii deficiency10.3
5alopecia universalis10.3
6ulcerative colitis10.3
7alopecia10.3
8myasthenia gravis10.3
9thyroiditis10.3
10autoimmune polyendocrinopathy type 310.3
11neuronitis10.0
12schizophrenia10.0
13graves' disease10.0CYP21A2
14antley-bixler syndrome10.0CYP21A2
15klinefelter's syndrome10.0CYP21A2
16diabetes insipidus10.0POMC
17adrenocortical carcinoma10.0POMC
18hypertension10.0POMC
19arthritis10.0POMC
20nephrotic syndrome10.0POMC
21insulin resistance10.0VWF, CYP21A2
22acute adrenal insufficiency10.0POMC, CYP21A2
23conn's syndrome10.0POMC, CYP21A2
24primary hyperoxaluria10.0VWF, POMC
25polycystic ovary syndrome10.0POMC, CYP21A2
26adrenal gland hyperfunction10.0POMC, CYP21A2
27precocious puberty10.0CYP21A2, POMC
28congenital adrenal hyperplasia10.0CYP21A2, POMC
29factor v leiden thrombophilia10.0CYP21A2, VWF
30hyperaldosteronism10.0POMC, CYP21A2
31adrenal adenoma10.0POMC, CYP21A2
32congenital heart defect10.0POMC, VWF
33hypopituitarism10.0POMC, CYP21A2
34cushing's syndrome10.0POMC, CYP21A2
35diabetes mellitus10.0VWF, POMC
36leydig cell tumor10.0CYP21A2, POMC
37hyperandrogenism10.0CYP21A2, POMC
38hypersensitivity reaction type ii disease10.0VWF, POMC
39addison's disease10.0CYP21A2, POMC
40obesity10.0POMC, CYP21A2
41type 2 diabetes mellitus10.0CYP21A2, VWF
42metabolic syndrome x10.0CYP21A2, POMC
43prion disease10.0VWF, POMC

Graphical network of the top 20 diseases related to Autoimmune Polyglandular Syndrome Type 3:



Diseases related to autoimmune polyglandular syndrome type 3

Clinical Features for Autoimmune Polyglandular Syndrome Type 3

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Drugs & Therapeutics for Autoimmune Polyglandular Syndrome Type 3

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Autoimmune Polyglandular Syndrome Type 3

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Anatomical Context for Autoimmune Polyglandular Syndrome Type 3

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Polyglandular Syndrome Type 3:

32
Cortex, Thyroid, Adrenal gland, Adrenal cortex

Animal Models for Autoimmune Polyglandular Syndrome Type 3 or affiliated genes

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Publications for Autoimmune Polyglandular Syndrome Type 3

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Genetic Variations for Autoimmune Polyglandular Syndrome Type 3

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Expression for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

Search GEO for disease gene expression data for Autoimmune Polyglandular Syndrome Type 3.

Pathways for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

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Compounds for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 49PharmGKB
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Compounds related to Autoimmune Polyglandular Syndrome Type 3 according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1biotin44 11 2411.6VWF, CYP21A2
2serine449.6POMC
3agarose449.6CYP21A2, VWF
4desmopressin44 59 28 1112.5POMC, VWF
5carbon449.5VWF, CYP21A2
6methimazole44 2 1111.5VWF, POMC
73beta-hydroxy-delta5-steroid449.5CYP21A2, POMC
8cortrosyn449.5CYP21A2, POMC
921-deoxycortisol44 2410.5CYP21A2, POMC
10metformin44 49 1111.5VWF, POMC
11nafarelin44 59 28 1112.5CYP21A2, POMC
12acth 1-24449.5CYP21A2, POMC
13cortisol28 2410.5POMC, CYP21A2
14fludrocortisone44 28 1111.5POMC, CYP21A2
1517-hydroxypregnenolone449.5CYP21A2, POMC
1611 deoxycortisol449.4CYP21A2, POMC
17doca449.4CYP21A2, POMC
18aminoglutethimide44 1110.4POMC, CYP21A2
19cortisone44 2410.4POMC, CYP21A2
20metyrapone59 44 1111.4POMC, CYP21A2
2117-hydroxyprogesterone44 2410.4CYP21A2, POMC
22spironolactone49 44 59 28 1113.4CYP21A2, POMC
2311beta-hydroxysteroid449.4CYP21A2, POMC
243beta-hydroxysteroid449.4CYP21A2, POMC
25ketoconazole44 28 11 2412.4POMC, CYP21A2
26dehydroepiandrosterone sulfate449.4POMC, CYP21A2
27citrate449.4VWF, POMC
28dhea449.4CYP21A2, POMC
29androstenedione44 2410.3CYP21A2, POMC
30formaldehyde44 2410.3VWF, POMC
31corticosterone44 59 2411.3CYP21A2, POMC
32catecholamine449.3POMC, CYP21A2
33hydrocortisone44 2 59 1112.3CYP21A2, POMC
34glycerol44 11 2411.3POMC, VWF
35aspirin44 49 28 2412.2VWF, POMC
36acth449.1CYP21A2, POMC
37ascorbic acid44 2410.1VWF, POMC
38gnrh449.0POMC, CYP21A2
39prednisolone44 28 1110.9POMC, CYP21A2, VWF
40thyroxine44 249.9POMC, CYP21A2, VWF
41epinephrine44 11 2410.9POMC, CYP21A2, VWF
42norepinephrine44 11 2410.9VWF, CYP21A2, POMC
43testosterone44 59 11 2411.9POMC, CYP21A2, VWF
44dexamethasone44 49 28 1111.9VWF, CYP21A2, POMC
45arginine448.8POMC, CYP21A2, VWF
46estrogen448.8POMC, CYP21A2, VWF
47ribonucleic acid448.7CYP21A2, POMC

GO Terms for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

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Products for genes affiliated with Autoimmune Polyglandular Syndrome Type 3

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Sources for Autoimmune Polyglandular Syndrome Type 3

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet