ITP
MCID: ATM004
MIFTS: 68

Autoimmune Thrombocytopenic Purpura (ITP) malady

Rare diseases, Immune diseases, Blood diseases categories

Summaries for Autoimmune Thrombocytopenic Purpura

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Idiopathic thrombocytopenic purpura (itp) is a bleeding disorder characterized by too few platelets in the blood. this is because platelets are being destroyed by the immune system. symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. with treatment, the chance of remission (a symptom-free period) is good. rarely, itp may become a chronic ailment in adults and reappear, even after remission. last updated: 4/22/2011

MalaCards: Autoimmune Thrombocytopenic Purpura, also known as thrombocytopenic purpura, autoimmune, is related to purpura and hepatitis. An important gene associated with Autoimmune Thrombocytopenic Purpura is FCGR2C (Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)), and among its related pathways are Jak/Stat Pathway and Arf6 signaling events. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds daclizumab and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and bone marrow, and related mouse phenotypes are other and skeleton.

Disease Ontology:9 A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.

Description from OMIM:48 188030

Aliases & Classifications for Autoimmune Thrombocytopenic Purpura

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 10diseasecard, 48OMIM, 46Novoseek, 59SNOMED-CT, 41NCIt, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

50
thrombocytopenic purpura, autoimmune:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

autoimmune thrombocytopenic purpura 9 44 11
thrombocytopenic purpura, autoimmune 10 48 50
immune thrombocytopenic purpura 9 50 63
idiopathic thrombocytopenic purpura 9 44
itp 44 50
thrombocytopenia due to platelet alloimmunization 63
purpura, thrombocytopenic, idiopathic 63
purpura thrombocytopenic idiopathic 46
thrombocytopenic purpura autoimmune 44
primary thrombocytopenic purpura 9
immune thrombocytopenia 50


External Ids:

Disease Ontology9 DOID:8924
NCIt41 C3446
MeSH36 D016553
OMIM48 188030
MESH via Orphanet37 D016553
ICD10 via Orphanet27 D69.3
SNOMED-CT via Orphanet60 234490009, 32273002
UMLS via Orphanet64 C0398650
ICD1026 D69.3

Related Diseases for Autoimmune Thrombocytopenic Purpura

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Autoimmune Thrombocytopenic Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1purpura32.3THPO
2hepatitis30.7CD40LG, IFNA2, IFNA1
3aplastic anemia30.7MPL, THPO
4thrombocytopenia30.6THPO, MPL, SELP, RECK, IFNA1, IFNA2
5hepatitis c30.6CD40LG, IFNA2, IFNA1, THPO
6hodgkin's lymphoma30.5CD40, IL2RA, SELP
7ulcerative colitis30.5THPO, SELP, IL2RA
8hypersplenism30.5THPO
9arteriosclerosis30.4CD40
10systemic lupus erythematosus30.4MPL, FCGR2C, RECK, IFNA1, IL2RA, CD40LG
11polycythemia30.4ITGB3, MPL, THPO
12thyroiditis30.4IFNA1
13measles30.4CD40LG, RECK
14viral hepatitis30.4IFNA1, IFNA2
15hypothyroidism30.4IFNA2, IFNA1
16acute lymphocytic leukemia30.4THPO, MPL, RECK, CD40
17bernard-soulier syndrome30.3ITGA2B, ITGB3, RECK, THPO
18antiphospholipid syndrome30.3CD40LG, SELP
19vasculitis30.3SELP, IFNA2, CD40LG
20chronic lymphocytic leukemia30.3CD40, CD40LG, IL2RA, THPO
21thrombocytopenia due to platelet alloimmunization30.3THPO, MPL, SELP, ITGA2B
22liver cirrhosis30.3IFNA2, IFNA1, THPO
23autoimmune hepatitis30.3IFNA1, CD40LG
24myocardial infarction30.3ITGA2B, ITGB3, RECK, SELP
25deficiency anemia30.3THPO, MPL, IFNA1, IFNA2
26diabetes mellitus30.3CD40LG, ITGA2B, RECK, SELP
27neutropenia30.2THPO, MPL, IFNA1, IFNA2, CD40
28thrombocytosis30.2THPO, MPL, SELP, IFNA1, IFNA2
29splenomegaly30.2THPO, MPL, IFNA1, IFNA2, IL2RA
30leukemia30.2THPO, MPL, RECK, IFNA1, IFNA2, ITGB3
31polycythemia vera30.1THPO, MPL, SELP, IFNA1, IFNA2, ITGB3
32glanzmann's thrombasthenia30.1ITGB3, ITGA2B
33vascular disease30.0SELP, RECK, ITGB3
34relapsing-remitting multiple sclerosis30.0IL2RA, IFNA1
35b-cell chronic lymphocytic leukemia30.0RECK, IL2RA, CD40LG, CD40
36multiple sclerosis29.9THPO, IFNA1, IL2RA, CD40
37nocardiosis10.5
38graves' disease10.5
39lupus erythematosus10.5
40mononeuropathy10.4
41crohn's disease10.4
42thrombotic thrombocytopenic purpura10.4
43autoimmune hemolytic anemia10.4
44common variable immunodeficiency10.4
45hemolytic anemia10.4
46myasthenia gravis10.4
47evans' syndrome10.4
48membranous glomerulonephritis10.4
49pituitary apoplexy10.4
50erythromelalgia10.4

Graphical network of the top 20 diseases related to Autoimmune Thrombocytopenic Purpura:



Diseases related to autoimmune thrombocytopenic purpura

Symptoms for Autoimmune Thrombocytopenic Purpura

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48OMIM
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Symptoms by clinical synopsis from OMIM:

188030

Clinical features from OMIM:

188030

Drugs & Therapeutics for Autoimmune Thrombocytopenic Purpura

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Thrombocytopenic Purpura

Drug clinical trials:

Search ClinicalTrials for Autoimmune Thrombocytopenic Purpura

Search NIH Clinical Center for Autoimmune Thrombocytopenic Purpura

Search CenterWatch for Autoimmune Thrombocytopenic Purpura

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Autoimmune Thrombocytopenic Purpura

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Anatomical Context for Autoimmune Thrombocytopenic Purpura

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34MalaCards
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MalaCards organs/tissues related to Autoimmune Thrombocytopenic Purpura:

34
Skin, Bone, Bone marrow, T cells, Liver, Spleen, Breast

Animal Models for Autoimmune Thrombocytopenic Purpura or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Autoimmune Thrombocytopenic Purpura:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.0CD40LG, ITGB3, RECK
2MP:00053907.8SELP, RECK, ITGB3, CD40LG, CD40
3MP:00053977.5CD40, THPO, MPL, SELP, ITGB3, ITGA2B
4MP:00053877.4THPO, MPL, SELP, ITGB3, ITGA2B, IL2RA

Publications for Autoimmune Thrombocytopenic Purpura

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Sources:
53PubMed
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Articles related to Autoimmune Thrombocytopenic Purpura:

(show top 50)    (show all 202)
idTitleAuthorsYear
1
Salvage therapy of autoimmune thrombocytopenic purpura revealing non-Hodgkin lymphoma by the thrombopoietin receptor agonist romiplostim. (21848881)
2012
2
Crohn's disease associated with severe autoimmune thrombocytopenic purpura. (17119395)
2006
3
Correlations among age, cytokines, lymphocyte subtypes, and platelet counts in autoimmune thrombocytopenic purpura. (16933252)
2006
4
Efficiency of rituximab in the treatment of autoimmune thrombocytopenic purpura associated with common variable immunodeficiency. (16823831)
2006
5
Assessment of a therapeutic strategy for adults with severe autoimmune thrombocytopenic purpura based on a bleeding score rather than platelet count. (15951296)
2005
6
Intravenous immunoglobulin for autoimmune thrombocytopenic purpura. (15866702)
2005
7
Autoimmune thrombocytopenic purpura and common variable immunodeficiency: analysis of 21 cases and review of the literature. (15232313)
2004
8
Severe autoimmune thrombocytopenic purpura during interferon-alpha therapy for chronic myelogenous leukemia. (15564735)
2004
9
Refractory autoimmune thrombocytopenic purpura: responses to treatment with a recombinant antibody to lymphocyte membrane antigen CD20 (rituximab). (14635207)
2003
10
Successful remission of chronic, refractory autoimmune thrombocytopenic purpura following non-myeloablative allogeneic stem cell transplantation. (12692634)
2003
11
Pathogenic T-cell responses in patients with autoimmune thrombocytopenic purpura. (14668632)
2003
12
Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura. (12139750)
2002
13
Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial. (11809183)
2002
14
Refractory autoimmune thrombocytopenic purpura treatment with Rituximab. (11279663)
2001
15
Transradial coronary stent placement in a patient with severe idiopathic autoimmune thrombocytopenic purpura. (10904444)
2000
16
Screening for autoimmune markers is unnecessary during follow-up of adults with autoimmune thrombocytopenic purpura and no autoimmune markers at onset. (10669152)
2000
17
Splenectomy during pregnancy: an option in treatment of autoimmune thrombocytopenic purpura. (10609737)
1999
18
Two cases of autoimmune thrombocytopenic purpura associated with antiphospholipid antibodies. (10399373)
1999
19
Immunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura (ITP). (9736217)
1998
20
Autoimmune thrombocytopenic purpura in a splenectomised patient. (10622094)
1998
21
Graves disease associated with autoimmune thrombocytopenic purpura. (9140276)
1997
22
Viral hepatitides and idiopathic (autoimmune) thrombocytopenic purpura. Is there any relationship? (9007734)
1996
23
Hepatitis C virus infection and autoimmune thrombocytopenic purpura. (8750160)
1995
24
Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura. (8298145)
1994
25
Incidence of autoantibodies to GPIIb/IIIa in chronic autoimmune thrombocytopenic purpura may be overestimated by the MAIPA. (8199041)
1994
26
Awake, blind nasotracheal intubation for cesarean section in a patient with autoimmune thrombocytopenic purpura and iatrogenic Cushing's syndrome. (8214677)
1993
27
T lymphocytes from autoimmune thrombocytopenic purpura show a defective activation and proliferation after cytoplasmic membrane and intracytoplasmic mitogenic signals. (8393613)
1993
28
Development and characterization of monoclonal antiplatelet autoantibodies from autoimmune thrombocytopenic purpura-prone (NZW x BXSB)F1 mice. (8338948)
1993
29
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. (8443385)
1993
30
CAMPATH-1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura. (8217808)
1993
31
Cellular immune mechanisms in chronic autoimmune thrombocytopenic purpura (ATP). (1472641)
1992
32
Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura. (1858783)
1991
33
Autoimmune thrombocytopenic purpura in pregnancy. (2025976)
1991
34
Antiplatelet autoantibody-related microparticles in patients with idiopathic (autoimmune) thrombocytopenic purpura. (2031972)
1991
35
Misdiagnosis of a normal fetal platelet count after coagulation of intrapartum scalp samples in autoimmune thrombocytopenic purpura. (1760060)
1991
36
Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. (3597777)
1987
37
Periodontal manifestations of acute autoimmune thrombocytopenic purpura. A case report. (3461151)
1986
38
Identification of glycoprotein Ib as a target for autoantibody in idiopathic (autoimmune) thrombocytopenic purpura. (2935206)
1986
39
Autoimmune thrombocytopenic purpura. (2413550)
1985
40
Autoimmune thrombocytopenic purpura: current concepts and recommended practices. (6383046)
1984
41
Treatment of adult autoimmune thrombocytopenic purpura with high-dose intravenous plasmin-cleaved gammaglobulins. (6683424)
1983
42
Plasma exchange in autoimmune thrombocytopenic purpura. (6684835)
1983
43
Chronic autoimmune thrombocytopenic purpura associated with haemophilia A. (6892061)
1982
44
A simple method for detecting complement-fixation by autologous platelets in autoimmune thrombocytopenic purpura. (7194758)
1981
45
Autoimmune thrombocytopenic purpura. (6157441)
1980
46
Pregnancy in patients with autoimmune thrombocytopenic purpura. (571205)
1979
47
Impaired lymphocyte transformation and capping in autoimmune thrombocytopenic purpura. (367467)
1979
48
An immunoenzyme histochemical technique for the detection of platelet antibodies from the serum of patients with idiopathic (autoimmune) thrombocytopenic purpura (ITP). (341958)
1977
49
Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). (4672230)
1972
50
Autoimmune thrombocytopenic purpura and the compensated thrombocytolytic state. (5106218)
1971

Variations for Autoimmune Thrombocytopenic Purpura

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Expression for genes affiliated with Autoimmune Thrombocytopenic Purpura

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Thrombocytopenic Purpura

Search GEO for disease gene expression data for Autoimmune Thrombocytopenic Purpura.

Pathways for genes affiliated with Autoimmune Thrombocytopenic Purpura

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Sources:
51PathCards, 5Cell Signaling Technology, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 55R&D Systems, 54QIAGEN
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Pathways related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.9THPO, MPL
29.8ITGB3, ITGA2B
39.8ITGA2B, ITGB3
49.8ITGA2B, ITGB3
59.7CD40LG, CD40
69.7CD40, CD40LG
79.7CD40, CD40LG
89.6IFNA2, IFNA1
99.6IFNA1, IFNA2
109.6IFNA2, IFNA1
119.5IL2RA, SELP
129.5CD40LG, CD40, FCGR2C
13
Show member pathways
9.5CD40, CD40LG, FCGR2C
14
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
9.5THPO, MPL, IL2RA
159.4FCGR2C, IFNA1, IFNA2
16
Show member pathways
9.3ITGA2B, SELP, ITGB3
179.3IL2RA, CD40LG, CD40
18
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.3CD40, IFNA2, IFNA1
199.3CD40LG, SELP, ITGB3
20
Show member pathways
9.3ITGB3, THPO, ITGA2B, MPL
219.2CD40LG, SELP, CD40
229.2CD40LG, SELP, CD40
239.1THPO, ITGB3, IL2RA, ITGA2B
24
Show member pathways
9.1THPO, ITGB3, ITGA2B, IL2RA
25
Show member pathways
9.1ITGB3, ITGA2B, IL2RA, THPO
26
Show member pathways
9.1IL2RA, THPO, ITGB3, ITGA2B
27
Show member pathways
9.1ITGA2B, IL2RA, THPO, ITGB3
28
Show member pathways
Type III interferon signaling39
8.9IFNA2, IFNA1, MPL, IL2RA
298.5IL2RA, IFNA2, ITGB3, IFNA1, ITGA2B
30
Show member pathways
8.4CD40, CD40LG, IL2RA, IFNA2, IFNA1
31
Show member pathways
8.1CD40LG, IFNA1, MPL, CD40, IFNA2, IL2RA
32
Show member pathways
7.9IFNA2, THPO, IL2RA, ITGA2B, ITGB3, IFNA1
33
Show member pathways
7.9SELP, ITGB3, IFNA2, IFNA1, MPL, THPO

Compounds for genes affiliated with Autoimmune Thrombocytopenic Purpura

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1daclizumab46 1210.7IL2RA, CD40LG, FCGR2C
2alemtuzumab46 1210.7IL2RA, CD40LG, FCGR2C
3hydroxychloroquine46 1210.6IFNA2, IL2RA, CD40LG
4mizoribine469.6IFNA2, IL2RA, IFNA1
5pentostatin46 62 30 1212.5IL2RA, IFNA1, IFNA2
6anagrelide46 1210.5THPO, MPL, IFNA1, IFNA2
7levamisole46 1210.4IFNA1, IFNA2, IL2RA
8clopidogrel46 52 25 1212.3ITGB3, CD40, SELP, CD40LG
9tirofiban46 1210.3CD40LG, SELP, ITGB3, ITGA2B
10lamivudine46 52 1211.2IFNA1, IL2RA, IFNA2
11thalidomide46 52 62 1212.1IFNA1, IFNA2, IL2RA, CD40LG
12ristocetin469.1SELP, RECK, ITGB3
13prednisolone46 30 1211.1IFNA1, CD40, IL2RA, IFNA2
14polyethylene glycol469.0MPL, CD40LG, IFNA2, IFNA1, THPO
15atorvastatin46 52 30 25 1213.0SELP, IL2RA, CD40, CD40LG
16indomethacin46 30 62 1212.0IFNA2, THPO, CD40LG, CD40, IL2RA
175fluorouracil469.0IFNA2, IL2RA, IFNA1, MPL, THPO
18gp 130469.0IL2RA, RECK, MPL, THPO
19neopterin468.9CD40LG, IFNA2, IL2RA, IFNA1, CD40
20epinephrine46 25 1210.8IL2RA, IFNA2, SELP, THPO, CD40LG
21cyclophosphamide46 52 1210.8CD40, IL2RA, IFNA2, IFNA1
22rapamycin468.8CD40, IFNA1, CD40LG, IL2RA, THPO
23formaldehyde46 259.8CD40LG, SELP, IL2RA, ITGA2B
24abciximab46 129.8FCGR2C, SELP, ITGB3, ITGA2B, CD40LG, CD40
25genistein46 30 62 3 25 1213.7CD40, THPO, SELP, CD40LG, IL2RA
26mycophenolate mofetil46 52 1210.7CD40LG, SELP, IFNA1, CD40, IL2RA
27aspirin46 52 30 2511.7THPO, CD40LG, IL2RA, MPL, ITGB3, SELP
28rituximab46 52 1210.6IFNA1, CD40, IL2RA, IFNA2, FCGR2C, CD40LG
29vincristine46 52 1210.6IFNA2, IFNA1, IL2RA, RECK
30iron46 259.6MPL, RECK, IFNA2, ITGB3, THPO
31histamine46 30 2510.6CD40, THPO, SELP, IFNA2, IL2RA, CD40LG
32alanine468.5THPO, ITGB3, IFNA2, IFNA1, MPL, CD40LG
33etoposide46 52 62 1211.4IL2RA, THPO, RECK, IFNA1, IFNA2
34rantes468.4CD40, THPO, SELP, IFNA1, IL2RA, CD40LG
35arachidonic acid46 30 25 1211.3ITGA2B, THPO, SELP, RECK, IFNA2
36polysaccharide468.3THPO, SELP, IL2RA, RECK, CD40LG
37aspartate468.3IFNA2, CD40LG, IL2RA, SELP, IFNA1, ITGB3
38dexamethasone46 52 30 1211.3SELP, IL2RA, CD40, CD40LG, THPO, IFNA1
39thymidine46 259.3THPO, IFNA1, CD40, IFNA2, IL2RA
40lysine468.1ITGA2B, IFNA2, RECK, IL2RA, ITGB3, MPL
41pge2468.1SELP, CD40, RECK, CD40LG, IL2RA
42doxorubicin46 52 1210.0RECK, CD40, CD40LG, IFNA2, IFNA1, IL2RA
43fibrinogen467.9CD40LG, THPO, CD40, SELP, RECK, ITGB3
44cyclosporin a46 30 629.8CD40LG, CD40, IL2RA, IFNA1, RECK, SELP
45estrogen467.7THPO, SELP, RECK, IFNA2, ITGB3, IL2RA
46adp46 30 259.6ITGA2B, ITGB3, SELP, CD40LG, RECK, MPL
47serine467.3IFNA1, ITGB3, RECK, ITGA2B, CD40LG, CD40
48cysteine466.8IFNA2, ITGA2B, SELP, MPL, THPO, RECK
49tyrosine466.8THPO, MPL, FCGR2C, SELP, RECK, IFNA2
50vegf466.7RECK, CD40LG, IL2RA, CD40, ITGB3, IFNA2

GO Terms for genes affiliated with Autoimmune Thrombocytopenic Purpura

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17Gene Ontology
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Cellular components related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin complexGO:0083059.8ITGB3, ITGA2B
2platelet alpha granule membraneGO:0310929.4SELP, ITGB3, ITGA2B
3external side of plasma membraneGO:0098978.5IL2RA, CD40LG, CD40, ITGA2B, SELP
4extracellular spaceGO:0056158.3THPO, SELP, IFNA2, CD40LG, CD40
5integral component of plasma membraneGO:0058878.2MPL, SELP, ITGB3, CD40, CD40LG, ITGA2B
6plasma membraneGO:0058866.7MPL, FCGR2C, SELP, RECK, ITGB3, ITGA2B

Biological processes related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:05102310.0CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:20003539.9CD40, CD40LG
3platelet aggregationGO:0705279.8ITGB3, ITGA2B
4positive regulation of protein phosphorylationGO:0019349.8CD40, ITGB3, THPO
5B cell proliferationGO:0421009.7CD40, CD40LG
6positive regulation of leukocyte migrationGO:0026879.7SELP, ITGA2B
7positive regulation of interleukin-12 productionGO:0327359.6CD40LG, CD40
8platelet degranulationGO:0025769.5SELP, ITGA2B, ITGB3
9cell surface receptor signaling pathwayGO:0071669.4MPL, IL2RA, IFNA2
10leukocyte cell-cell adhesionGO:0071599.2CD40LG, SELP
11inflammatory responseGO:0069549.1SELP, CD40, CD40LG, IFNA2
12blood coagulationGO:0075968.6ITGA2B, ITGB3, IFNA2, THPO, SELP, MPL
13platelet activationGO:0301688.3SELP, ITGB3, ITGA2B, CD40LG, MPL, THPO

Molecular functions related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.5CD40LG, IFNA2, THPO

Products for genes affiliated with Autoimmune Thrombocytopenic Purpura

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Autoimmune Thrombocytopenic Purpura

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet