ITP
MCID: ATM004
MIFTS: 68

Autoimmune Thrombocytopenic Purpura (ITP) malady

Immune diseases, Blood diseases categories

Summaries for Autoimmune Thrombocytopenic Purpura

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Idiopathic thrombocytopenic purpura (itp) is a bleeding disorder characterized by too few platelets in the blood. this is because platelets are being destroyed by the immune system. symptoms may include bruising, nosebleed or bleeding in the mouth, bleeding into the skin, and abnormally heavy menstruation. with treatment, the chance of remission (a symptom-free period) is good. rarely, itp may become a chronic ailment in adults and reappear, even after remission. last updated: 4/22/2011

MalaCards: Autoimmune Thrombocytopenic Purpura, also known as thrombocytopenic purpura, autoimmune, is related to purpura and thrombocytopenia. An important gene associated with Autoimmune Thrombocytopenic Purpura is FCGR2C (Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)), and among its related pathways are Malaria and Primary immunodeficiency. The drugs azathioprine and cyclophosphamide and the compounds aspartate and gamma globulin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and skin, and related mouse phenotypes are integument and cellular.

Disease Ontology:8 A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies.

Description from OMIM:46 188030

Aliases & Classifications for Autoimmune Thrombocytopenic Purpura

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases, Blood diseases


Characteristics (Orphanet epidemiological data):

48
thrombocytopenic purpura, autoimmune:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Variable


Aliases & Descriptions:

autoimmune thrombocytopenic purpura 8 42 10
thrombocytopenic purpura, autoimmune 9 46 48
immune thrombocytopenic purpura 8 48 60
idiopathic thrombocytopenic purpura 8 42
itp 42 48
thrombocytopenia due to platelet alloimmunization 60
purpura, thrombocytopenic, idiopathic 60
thrombocytopenic purpura autoimmune 42
purpura thrombocytopenic idiopathic 44
primary thrombocytopenic purpura 8
immune thrombocytopenia 48


External Ids:

Disease Ontology8 DOID:8924
NCIt39 C3446
OMIM46 188030
MeSH34 D016553
MESH via Orphanet35 D016553
ICD10 via Orphanet26 D69.3
SNOMED-CT via Orphanet57 234490009, 32273002
UMLS via Orphanet61 C0398650
ICD1025 D69.3

Related Diseases for Autoimmune Thrombocytopenic Purpura

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Autoimmune Thrombocytopenic Purpura via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1purpura32.0ADAMTS13, THPO, CD79A
2thrombocytopenia30.8IFNA2, ADAMTS13, SELP, THPO, NAAA, RECK
3hepatitis30.7IFNA2, IFNA1, THPO, SELP
4graves' disease30.6CD40, IL2RA
5lupus erythematosus30.6CD40LG, CD79A
6hepatitis c30.6IFNA2, IFNA1, CD40LG, THPO
7systemic lupus erythematosus30.6IFNA1, MPL, CD40, CD40LG, CD79A, RECK
8autoimmune hemolytic anemia30.5CD79A, CD40LG
9evans' syndrome30.5ADAMTS13
10disseminated intravascular coagulation30.5ADAMTS13, THPO
11glomerulonephritis30.4CD79A, CD40LG
12neuropathy30.4CD79A
13ulcerative colitis30.4CD79A, IL2RA, THPO, SELP
14leukemia30.4IFNA2, IFNA1, ITGB3, ITGA2B, MPL, CD40
15hyperthyroidism30.3CD40
16sarcoma30.2RECK, THPO
17hypothyroidism30.2IFNA1
18mumps30.2CD79A
19kaposi's sarcoma30.2IFNA1
20chronic lymphocytic leukemia30.2CD40, CD40LG, IL2RA, THPO
21portal vein thrombosis30.2THPO
22arteriosclerosis30.2CD40
23stroke, ischemic30.2ITGA2B
24thrombocytosis30.2IFNA2, IFNA1, MPL, THPO, SELP
25acute leukemia30.2THPO, MPL
26vasculitis30.2SELP, CD79A, CD40LG, IFNA2
27polycythemia30.2THPO, MPL, ITGB3
28meningitis30.2CD79A
29viral hepatitis30.2IFNA2, IFNA1
30thrombocytopenia due to platelet alloimmunization30.2ITGA2B, MPL, THPO, SELP
31acute lymphocytic leukemia30.2THPO, RECK, CD40, MPL
32nephrotic syndrome30.2IL2RA, CD79A
33thyroiditis30.2IFNA1, CD79A
34celiac disease30.2CD79A
35bernard-soulier syndrome30.2ITGB3, ITGA2B, ITGA2, RECK, THPO
36pneumonia30.2CD79A, CD40
37rubella30.2CD79A, CD40LG
38neutropenia30.2IFNA2, IFNA1, MPL, CD40, THPO
39brucellosis30.2ITGA2, CD79A
40antiphospholipid syndrome30.2CD40LG, CD79A, SELP, ADAMTS13
41measles30.2RECK, CD79A, CD40LG
42polycythemia vera30.2IFNA2, IFNA1, ITGB3, MPL, THPO, SELP
43liver cirrhosis30.2IFNA2, IFNA1, THPO, ADAMTS13
44common variable immune deficiency30.2CD40, CD40LG, CD79A, IL2RA
45myocardial infarction30.2ITGB3, ITGA2B, ITGA2, RECK, SELP, ADAMTS13
46diabetes mellitus30.2ITGA2B, ITGA2, CD40LG, CD79A, RECK, SELP
47deficiency anemia30.2IFNA2, IFNA1, MPL, CD79A, NAAA, THPO
48sarcoidosis30.1SELP, IL2RA
49infectious mononucleosis30.1CD40LG, CD79A
50myeloid leukemia29.9THPO, MPL

Graphical network of the top 20 diseases related to Autoimmune Thrombocytopenic Purpura:



Diseases related to autoimmune thrombocytopenic purpura

Clinical Features for Autoimmune Thrombocytopenic Purpura

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Sources:
46OMIM
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Clinical features from OMIM:

188030

Clinical synopsis from OMIM:

188030

Drugs & Therapeutics for Autoimmune Thrombocytopenic Purpura

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Thrombocytopenic Purpura

Drug clinical trials:

Search ClinicalTrials for Autoimmune Thrombocytopenic Purpura

Search NIH Clinical Center for Autoimmune Thrombocytopenic Purpura

Search CenterWatch for Autoimmune Thrombocytopenic Purpura

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Autoimmune Thrombocytopenic Purpura

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Anatomical Context for Autoimmune Thrombocytopenic Purpura

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32MalaCards
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MalaCards organs/tissues related to Autoimmune Thrombocytopenic Purpura:

32
Bone marrow, Bone, Skin, T cells, Spleen, Liver, Thyroid, Breast, B cells

Animal Models for Autoimmune Thrombocytopenic Purpura or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Thrombocytopenic Purpura:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.0RECK, CD40LG, ITGA2, FOXG1
2MP:00053848.0FOXG1, MPL, POU2F3, CD40, CD79A, IL2RA
3MP:00053877.7MPL, ITGA2B, ITGB3, FOXG1, CD40, CD40LG
4MP:00053767.5FOXG1, ITGB3, ITGA2B, ITGA2, MPL, CD40
5MP:00053977.4ADAMTS13, FOXG1, ITGB3, ITGA2B, ITGA2, MPL

Publications for Autoimmune Thrombocytopenic Purpura

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50PubMed
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Articles related to Autoimmune Thrombocytopenic Purpura:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Measurement and prevalence of circulating ADAMTS13-specific immune complexes in autoimmune thrombotic thrombocytopenic purpura. (24354764)
2013
2
A beneficial effect of rituximab on autoimmune thrombotic thrombocytopenic purpura: Just a B-cell depletion? (24365135)
2013
3
The significance of ADAMTS13 in a patient with thrombotic thrombocytopenic purpura complicated autoimmune hepatitis. (19277430)
2009
4
Rituximab therapy in two children with autoimmune thrombotic thrombocytopenic purpura. (19399522)
2009
5
Autoimmune thrombocytopenic purpura with spuriously normal platelet count and 'punch-hole' red cells. (17897292)
2007
6
A single-institution, 20-year prospective experience with an affordable Fc-receptor blockade method to treat patients with chronic, refractory autoimmune thrombocytopenic purpura. (18402333)
2007
7
Autoimmune thrombocytopenic purpura, autoimmune hemolytic anemia and gastric cancer appeared in a patient with myasthenia gravis. (16679706)
2006
8
Does H. Pylori infection play a role in idiopathic thrombocytopenic purpura and in other autoimmune diseases? (15929756)
2005
9
Intravenous immunoglobulin and autoimmune thrombocytopenic purpura: 22 years on. (14984554)
2004
10
Fatal intracranial hemorrhage in a pregnant patient with autoimmune thrombocytopenic purpura. (14711111)
2003
11
Long-term follow-up of chronic autoimmune thrombocytopenic purpura refractory to splenectomy: a prospective analysis. (12648082)
2003
12
Multidrug resistance-1 (MDR-1) in autoimmune disorders III: increased P-glycoprotein activity in lymphocytes from immune thrombocytopenic purpura patients. (12829023)
2003
13
T-gamma large granular lymphocyte leukemia associated with amegakaryocytic thrombocytopenic purpura, SjAPgren's syndrome, and polyglandular autoimmune syndrome type II, with subsequent development of pure red cell aplasia. (11835350)
2002
14
Effect of Helicobacter pylori eradication on platelet recovery in Japanese patients with chronic idiopathic thrombocytopenic purpura and secondary autoimmune thrombocytopenic purpura. (12139750)
2002
15
Intravenous immunoglobulin or high-dose methylprednisolone, with or without oral prednisone, for adults with untreated severe autoimmune thrombocytopenic purpura: a randomised, multicentre trial. (11809183)
2002
16
Significance of chemokines and soluble CD40 ligand in patients with autoimmune thrombocytopenic purpura. (12460235)
2002
17
Crescentic glomerulonephritis with positive antineutrophil cytoplasmic autoantibody specific for myeloperoxidase associated with autoimmune hemolytic anemia and thrombocytopenic purpura. (10939540)
2000
18
Splenectomy during pregnancy: an option in treatment of autoimmune thrombocytopenic purpura. (10609737)
1999
19
The response to high-dose intravenous immunoglobulin or steroids is not predictive of outcome after splenectomy in adults with autoimmune thrombocytopenic purpura. (10554833)
1999
20
Autoimmune thrombocytopenic purpura (AITP) and acquired thrombasthenia due to autoantibodies to GP IIb-IIIa in a patient with an unusual platelet membrane glycoprotein composition. (9462551)
1998
21
Directions for research in autoimmune thrombocytopenic purpura (ITP). (9736226)
1998
22
Identification of autoimmune thrombocytopenic purpura-related epitopes using phage-display peptide library. (9557164)
1998
23
Monoclonal anti-D is not effective in the treatment of chronic autoimmune thrombocytopenic purpura. (9354835)
1997
24
Dapsone for chronic autoimmune thrombocytopenic purpura: a report of 66 cases. (9163598)
1997
25
A patient with autoimmune thrombocytopenic purpura demonstrating serum antibodies reactive with mouse cross-reactive idiotypes. (7586737)
1995
26
Incidence of autoantibodies to GPIIb/IIIa in chronic autoimmune thrombocytopenic purpura may be overestimated by the MAIPA. (8199041)
1994
27
Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. (8443385)
1993
28
Severe chronic autoimmune thrombocytopenic purpura is associated with an expansion of CD56+ CD3- natural killer cells subset. (7689873)
1993
29
Ascorbic acid for the treatment of autoimmune thrombocytopenic purpura. (1398308)
1992
30
Autoimmune thrombocytopenic purpura in pregnancy. (2025976)
1991
31
Effect of high-dose dexamethasone in prednisone-resistant autoimmune thrombocytopenic purpura (ITP). (1961352)
1991
32
Autoantibodies against platelet glycoprotein Ib/IX: a frequent finding in autoimmune thrombocytopenic purpura. (1720324)
1991
33
Late appearance of thrombotic thrombocytopenic purpura after autoimmune hemolytic anemia and in the course of chronic autoimmune thrombocytopenic purpura: two case reports. (2042447)
1991
34
Treatment of autoimmune thrombocytopenic purpura. (2131713)
1990
35
Treatment of chronic autoimmune thrombocytopenic purpura with ascorbate. (2372515)
1990
36
Resolution of severe thrombocytopenia in a pregnant patient with rhesus-negative blood with autoimmune thrombocytopenic purpura after intravenous rhesus immune globulin. (2160193)
1990
37
Human immunodeficiency virus-associated autoimmune thrombocytopenic purpura: a review. (2643870)
1989
38
Periodontal manifestations of acute autoimmune thrombocytopenic purpura. A case report. (3461151)
1986
39
Identification of glycoprotein Ib as a target for autoantibody in idiopathic (autoimmune) thrombocytopenic purpura. (2935206)
1986
40
Immunoregulatory defect in patients with autoimmune thrombocytopenic purpura (ATP). (2949403)
1986
41
The use of 125I labelled staphylococcal protein A in the diagnosis of autoimmune thrombocytopenic purpura and other immune mediated thrombocytopenias. (3725418)
1986
42
Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies (anti-Rh0(D). (6430368)
1984
43
Bleeding on patients with autoimmune thrombocytopenic purpura and normal platelet count. (6232698)
1984
44
Leukocyte migration inhibition of buffy coats from patients with autoimmune thrombocytopenic purpura when exposed to normal platelets: modulation by transfer factor. (6360249)
1984
45
Vincristine-loaded platelets for autoimmune thrombocytopenic purpura. (6889900)
1982
46
Hereditary autoimmune thrombocytopenic purpura: an immunologic and genetic study. (7195175)
1981
47
Autoimmune thrombocytopenic purpura. (6157441)
1980
48
Pregnancy in patients with autoimmune thrombocytopenic purpura. (571205)
1979
49
Association of HLA-DRw2 with autoimmune thrombocytopenic purpura. (571874)
1979
50
HLA matching in autoimmune thrombocytopenic purpura. (557983)
1977

Genetic Variations for Autoimmune Thrombocytopenic Purpura

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Expression for genes affiliated with Autoimmune Thrombocytopenic Purpura

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Thrombocytopenic Purpura

Search GEO for disease gene expression data for Autoimmune Thrombocytopenic Purpura.

Pathways for genes affiliated with Autoimmune Thrombocytopenic Purpura

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29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
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Pathways related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3CD40
210.1CD79A
3
Hide members
9.8ITGB3, ITGA2B, SELP
49.7ITGB3, CD40LG, SELP
59.7ITGA2, ITGA2B, ITGB3
69.7ITGA2, ITGA2B, ITGB3
79.7ITGB3, ITGA2B, ITGA2
89.7CD40, CD40LG, IL2RA
9
Hide members
9.6THPO, MPL, ITGA2B, ITGB3
10
Hide members
9.2IFNA1, MPL, CD40, IL2RA
11
Hide members
9.2THPO, IL2RA, ITGA2, ITGA2B, ITGB3
129.2ITGB3, ITGA2B, ITGA2, IL2RA, THPO
139.1IFNA2, IFNA1, MPL, IL2RA
14
Hide members
8.8THPO, IL2RA, CD79A, ITGA2, ITGA2B, ITGB3
15
Hide members
8.8ITGB3, ITGA2B, ITGA2, CD79A, IL2RA, THPO
16
Hide members
8.8IFNA2, IFNA1, CD40, CD40LG, IL2RA
17
Hide members
8.6IFNA2, IFNA1, ITGB3, ITGA2B, ITGA2, MPL
188.6IFNA2, IFNA1, ITGB3, ITGA2B, ITGA2, IL2RA
19
Hide members
8.5IFNA2, IFNA1, CD40, CD40LG, CD79A, IL2RA
20
Hide members
8.1THPO, IFNA2, IFNA1, ITGB3, ITGA2B, ITGA2

Compounds for genes affiliated with Autoimmune Thrombocytopenic Purpura

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44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1aspartate4410.5CD40LG
2gamma globulin4410.5IFNA2
3estrogen4410.2CD79A, THPO
4daclizumab44 1110.9CD40LG, FCGR2C, IL2RA
5blys449.9CD40, CD40LG, CD79A
6hydroxychloroquine44 1110.8CD40LG, IL2RA, IFNA2
7creatinine449.7SELP, ADAMTS13, CD79A, THPO
8thromboxane44 2410.7ITGA2, THPO, SELP, MPL
9pentostatin44 59 28 1112.7IFNA2, IL2RA, IFNA1
10tuberculin449.7CD79A, IL2RA, CD40LG
11ivig449.6IL2RA, CD40, CD79A, CD40LG
12alemtuzumab44 1110.6CD40LG, FCGR2C, IL2RA
13anagrelide44 1110.6IFNA2, IFNA1, MPL, THPO
14tirofiban44 1110.6ITGA2B, ITGA2, CD40LG, SELP, ITGB3
15clopidogrel49 44 11 2412.6ITGA2, SELP, CD40LG, CD40, ITGB3
16adp44 28 2411.5MPL, CD40LG, ITGA2B, ITGA2, CD40
17ristocetin449.5RECK, ITGB3, SELP, ADAMTS13
18abciximab44 1110.5FCGR2C, ITGB3, ITGA2B, CD40, CD40LG, SELP
19reticulin449.5MPL, CD79A, IFNA1
20theophylline44 28 11 2412.4CD40LG, CD79A, IL2RA, SELP
21mizoribine449.4IL2RA, IFNA1, IFNA2, CD79A
22agar449.4CD79A, THPO, MPL
23formaldehyde44 2410.4CD40LG, CD79A, ITGA2B, SELP, IL2RA
24dexamethasone44 49 28 1112.3IFNA1, CD79A, CD40LG
25rantes449.3IL2RA, IFNA1, CD40, CD40LG, THPO
26cyclophosphamide44 49 1111.2ADAMTS13, IFNA2, IFNA1, CD40, IL2RA
27prednisolone44 28 1111.1CD79A, IL2RA, CD40, IFNA1, IFNA2
28thalidomide44 49 59 1112.0IFNA1, IFNA2, IL2RA, CD40LG
29mycophenolate mofetil44 49 1110.9IL2RA, SELP, CD79A, CD40LG, CD40, IFNA1
30phosphatidylserine44 28 1110.9ITGB3, SELP, RECK, CD79A, CD40LG
31polyethylene glycol448.9THPO, CD79A, MPL, IFNA1, IFNA2, CD40LG
325fluorouracil448.9IFNA2, IFNA1, THPO, IL2RA, MPL
33histamine44 28 2410.9THPO, IL2RA, CD79A, CD40LG, CD40, IFNA2
34neopterin448.9IL2RA, CD79A, CD40LG, CD40, IFNA2, IFNA1
35vincristine44 49 1110.8ADAMTS13, IFNA2, IFNA1, RECK, IL2RA
36steroid448.8THPO, IFNA2, IL2RA, ADAMTS13, CD79A, ITGB3
37epinephrine44 11 2410.8IL2RA, IFNA2, ITGA2, CD79A, SELP, THPO
38arachidonic acid44 28 11 2411.7IFNA2, ITGA2B, ITGA2, THPO, SELP, RECK
39aspirin44 49 28 2411.7MPL, CD40LG, CD79A, IL2RA, ITGA2, THPO
40doxorubicin44 49 1110.5IFNA2, CD40LG, RECK, IL2RA, IFNA1, CD40
41polysaccharide448.5CD79A, ITGA2, RECK, IL2RA, THPO, SELP
42rituximab44 49 1110.5FCGR2C, CD40, IFNA1, IFNA2, CD40LG, CD79A
43lysine448.4ITGA2B, ITGA2, MPL, RECK, ITGB3, IL2RA
44cyclosporin a44 28 5910.0IFNA1, CD40, CD40LG, CD79A, RECK, IL2RA
45fibrinogen447.9THPO, ADAMTS13, SELP, ITGB3, ITGA2B, ITGA2
46vegf447.9IFNA2, IFNA1, MPL, CD40, IL2RA, SELP
47retinoic acid44 248.5POU2F3, CD40, CD40LG, CD79A, ITGA2, IFNA1
48tyrosine447.4SELP, THPO, MPL, CD40, RECK, ITGA2
49heparin44 28 11 2410.4RECK, ADAMTS13, SELP, CD79A, ITGA2, IL2RA
50cysteine447.3IL2RA, THPO, SELP, RECK, CD79A, CD40LG

GO Terms for genes affiliated with Autoimmune Thrombocytopenic Purpura

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16Gene Ontology
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Cellular components related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:0310929.7SELP, ITGA2B, ITGB3
2integrin complexGO:0083059.4ITGB3, ITGA2B, ITGA2
3external side of plasma membraneGO:0098978.5SELP, ITGA2B, ITGA2, CD40, CD40LG, CD79A
4plasma membraneGO:0058867.2ITGA2B, ITGA2, MPL, CD40, CD40LG, CD79A

Biological processes related to Autoimmune Thrombocytopenic Purpura according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:05102310.0CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:200035310.0CD40LG, CD40
3B cell proliferationGO:0421009.8CD79A, CD40LG, CD40
4platelet degranulationGO:0025769.7ITGB3, ITGA2B, SELP
5integrin-mediated signaling pathwayGO:0072299.6ITGB3, ITGA2B, ITGA2, ADAMTS13
6cell-matrix adhesionGO:0071609.5ITGB3, ITGA2B, ITGA2, ADAMTS13
7inflammatory responseGO:0069549.4SELP, CD40LG, CD40, IFNA2
8blood coagulationGO:0075968.9IFNA2, ITGB3, ITGA2B, ITGA2, MPL, THPO
9platelet activationGO:0301688.8ADAMTS13, ITGB3, ITGA2B, MPL, CD40, CD40LG
10extracellular matrix organizationGO:0301988.8RECK, ITGA2, ITGA2B, ITGB3

Products for genes affiliated with Autoimmune Thrombocytopenic Purpura

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Thrombocytopenic Purpura

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet