MCID: ATM003
MIFTS: 65

Autoimmune Thyroiditis malady

Rare diseases, Endocrine diseases, Immune diseases categories

Summaries for Autoimmune Thyroiditis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Hashimoto’s syndrome is a form of chronic inflammation of the thyroid gland. the inflammation results in damage to the thyroid gland and reduced thyroid function or “hypothyroidism,” meaning the gland doesn’t make enough thyroid hormone for the needs of the body. symptoms of hashimoto’s syndrome may include goiter, a feeling of fullness in the throat, tiredness, weight gain, cold intolerance, and a slowed heart rate. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it commonly appears between age 40 and age 60. a person with hashimoto’s syndrome may not always need treatment. when it is needed, the condition is treated with synthetic thyroid hormone. last updated: 12/15/2010

MalaCards: Autoimmune Thyroiditis, also known as hashimoto thyroiditis, is related to thyroiditis and hypothyroidism. An important gene associated with Autoimmune Thyroiditis is HT (Hashimoto thyroiditis), and among its related pathways are Immune response Bacterial infections in normal airways and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs thyroglobulin and thyroid (usp) and the compounds tarc and ccl3 have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and t cells, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:9 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Wikipedia:66 Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis, is a disease in which the body interprets the... more...

Aliases & Classifications for Autoimmune Thyroiditis

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Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 22Genetics Home Reference, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


Aliases & Descriptions:

autoimmune thyroiditis 9 44 22 11 63
hashimoto thyroiditis 9 10 23 22 48
chronic lymphocytic thyroiditis 9 44 22
hashimoto's disease 9 44 22
lymphocytic thyroiditis 9 22
hashimoto's syndrome 9 44
hashimoto disease 22 63
autoimmune chronic lymphocytic thyroiditis 22
chronic lymphocytic thyroiditides 22
hashimoto's thyroiditis 9
hashimotos thyroiditis 46
thyroiditis, chronic 44
thyroiditis chronic 46
hashimoto syndrome 22
hashimoto's struma 44
hashimoto struma 22


External Ids:

Disease Ontology9 DOID:7188
NCIt41 C27191
ICD1026 E06.2, E06.3

Related Diseases for Autoimmune Thyroiditis

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Subacute Thyroiditis Acute Thyroiditis
Thyroiditis

Diseases related to Autoimmune Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.3TPO, TG
2hypothyroidism31.1TPO, TG
3celiac disease31.0TG, TPO
4papillary thyroid carcinoma30.8TPO, TG
5hepatitis c30.8CXCL11, CXCL10
6vitiligo30.8TPO, AIRE
7type 1 diabetes mellitus30.7CXCL10, TG, TPO, AIRE
8graves' disease30.7CXCL10, TG, TPO, AIRE
9goiter30.6TPO, TG
10hyperthyroidism30.6TPO, TG
11thyroid cancer30.4TG, TPO
12autoimmune hepatitis30.4TPO, AIRE
13myxedema30.3TPO, TG
14thyrotoxicosis30.3TG, TPO
15turner syndrome30.3TG, TPO
16endemic goiter30.2TG, TPO
17subacute thyroiditis30.1TG, TPO
18nodular goiter30.0TG, TPO
19pendred syndrome30.0TG, TPO
20congenital hypothyroidism30.0TPO, TG
21dermatitis30.0CXCL11, CXCL10
22papillary carcinoma30.0TPO, TG
23atherosclerosis30.0CXCL11, CXCL10, TPO
24diabetes mellitus10.6
25hepatitis10.6
26obesity10.5
27subacute lymphocytic thyroiditis10.4
28granuloma annulare10.4
29hypothyroidism, autoimmune10.4
30cryoglobulinemia10.4
31arthritis10.4
32urticaria10.3
33gastritis10.3
34glomerulonephritis10.3
35lupus erythematosus10.3
36nephrotic syndrome10.3
37rheumatoid arthritis10.3
38autoimmune polyglandular syndrome type 310.3
39sjogren's syndrome10.2
40cushing's syndrome10.2
41systemic lupus erythematosus10.2
42bipolar disorder10.2
43breast cancer10.2
44multiple sclerosis10.2
45psoriasis10.2
46sarcoidosis10.2
47allergic autoimmune thyroiditis10.2
48hashimoto's encephalitis10.2
49crohn's disease10.1
50ankylosing spondylitis10.1

Graphical network of the top 20 diseases related to Autoimmune Thyroiditis:



Diseases related to autoimmune thyroiditis

Symptoms for Autoimmune Thyroiditis

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Drugs & Therapeutics for Autoimmune Thyroiditis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Thyroiditis

Search NIH Clinical Center for Autoimmune Thyroiditis

Search CenterWatch for Autoimmune Thyroiditis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Autoimmune Thyroiditis

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23GTR
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Genetic tests related to Autoimmune Thyroiditis:

id Genetic test Affiliating Genes
1 Hashimoto Thyroiditis23

Anatomical Context for Autoimmune Thyroiditis

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Autoimmune Thyroiditis:

34
Thyroid, T cells, Heart, B cells, Monocytes, Breast, Testes, Eye, Lymph node, Bone, Bone marrow, Brain, Endothelial, Salivary gland, Skin, Whole blood, Ovary, Pituitary

FMA organs/tissues related to Autoimmune Thyroiditis:

15
Thyroid gl

Animal Models for Autoimmune Thyroiditis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Autoimmune Thyroiditis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7ACADS, CXCL10, TG, TPO, AIRE

Publications for Autoimmune Thyroiditis

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53PubMed
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Articles related to Autoimmune Thyroiditis:

(show top 50)    (show all 841)
idTitleAuthorsYear
1
Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. (23253044)
2013
2
A possible association of hypokalaemic periodic paralysis, autoimmune thyroiditis and neuromyotonia. (24385062)
2013
3
The misdiagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis as masked depression in an elderly euthyroid woman. (23453127)
2013
4
Ultrasonographic characterization of cervical lymphadenopathy in chronic autoimmune thyroiditis. (23167267)
2013
5
Is autoimmune thyroiditis a risk factor for early atherosclerosis in premenopausal women even if in euthyroid status? (23184180)
2013
6
Xiaoyin recipe ( ) for psoriasis induces a Th1/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats. (22311410)
2012
7
Circulating CXCL11 and CXCL10 are increased in hepatitis C-associated cryoglobulinemia in the presence of autoimmune thyroiditis. (22160826)
2012
8
Invariant NKT Cell Lines Derived from the NODA^H2 Mouse Enhance Autoimmune Thyroiditis. (21603172)
2011
9
The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. (21198744)
2011
10
SLC26A4 expression among autoimmune thyroid tissues. (21035230)
2011
11
Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis. (21738252)
2011
12
"Hypoechoic triangle": a new sonographic sign or marker of advanced autoimmune thyroiditis. (21323587)
2011
13
The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. (20356797)
2010
14
Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases]. (19947439)
2009
15
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. (20134044)
2009
16
Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. (17919982)
2008
17
Altered expression of T lymphocyte surface markers in children with chronic autoimmune thyroiditis. (19218661)
2008
18
Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese. (18058260)
2007
19
Association analysis of interleukin gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (17964974)
2007
20
Antigenic determinants to GAD autoantibodies in patients with type 1 diabetes with and without autoimmune thyroid disease. (17130557)
2006
21
Soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases: relation to humoral immune response markers. (17357290)
2006
22
Incidence of iodine deficiency in patients presenting with goitre--discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis--clinical, hormonal and urinary iodine excretion studies. (16509527)
2006
23
Diagnosis of autoimmune thyroid disease]. (16405253)
2005
24
Neonatal stimulation of the thyroid gland with iodine or suppression during adolescence with triiodothyronine changes the prevalence of autoimmune thyroiditis in BB rats. (15362968)
2004
25
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
26
Consequences of autoimmune thyroiditis before, during and after pregnancy. (14605606)
2003
27
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. (14746804)
2003
28
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
29
Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease. (14679088)
2003
30
Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto's encephalitis? (14616889)
2003
31
Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. (12848996)
2002
32
Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996. (12097200)
2002
33
Etiopathogenesis of autoimmune thyroiditis]. (12635359)
2002
34
Immune intervention effects on the induction of experimental autoimmune thyroiditis. (12674776)
2002
35
Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases. (11217812)
2001
36
Usefulness of screening program for celiac disease in autoimmune thyroiditis. (10711459)
2000
37
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. (11129116)
2000
38
Fine-needle biopsy cytology in autoimmune thyroiditis. (10756865)
1998
39
Somatic hypermutation in autoimmune thyroid disease. (9602367)
1998
40
The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis. (9878080)
1998
41
Autoimmune thyroid disease in patients with type 1 diabetes mellitus]. (9588075)
1998
42
No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM. (9421385)
1998
43
Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population. (9285944)
1997
44
Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. (8938107)
1996
45
Isolation of thyroid peroxidase and lack of autoantibodies to the enzyme in dogs with autoimmune thyroid disease. (7695146)
1995
46
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
47
Deregulated production of interleukin-8 (IL-8) in autoimmune thyroid disease studied by newly developed IL-8 radioimmunoassay. (8003701)
1993
48
The relationship between autoimmune thyroid disease and iodine intake: a review. (1345585)
1992
49
Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. (1829139)
1991
50
Thyroid peroxidase/microsomal antibodies are not identical with thyroid cytotoxic antibodies in autoimmune thyroiditis. (2239089)
1990

Variations for Autoimmune Thyroiditis

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Expression for genes affiliated with Autoimmune Thyroiditis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Thyroiditis

Search GEO for disease gene expression data for Autoimmune Thyroiditis.

Pathways for genes affiliated with Autoimmune Thyroiditis

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Sources:
51PathCards, 61Thomson Reuters, 55R&D Systems, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 54QIAGEN
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Compounds for genes affiliated with Autoimmune Thyroiditis

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 3BitterDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1tarc469.9CXCL11, CXCL10
2ccl346 3010.9CXCL11, CXCL10
3ccl446 3010.9CXCL10, CXCL11
4iodotyrosine46 2510.9TG, TPO
5diiodotyrosine469.9TG, TPO
6perchlorate469.9TG, TPO
7sodium iodide469.8TG, TPO
8propylthiouracil46 3 1211.8TPO, TG
9gliadin469.8TG, TPO
10chromium469.8TG, TPO
11iodine46 2510.8TG, TPO
12amiodarone46 52 30 1212.8TPO, TG
13125i469.8TG, TPO
14iodide46 2510.8TG, TPO
15cardiolipin46 1210.8TG, TPO
16methimazole46 3 1211.8TPO, TG
17selenium46 2510.7TG, TPO
18triiodothyronine469.5TG, TPO
19sodium dodecylsulfate469.5TG, TPO
20hydrocortisone46 3 62 1212.5TPO, TG, CXCL10
21suramin46 30 1211.4TG, CXCL10
22gold469.4CXCL10, TG, TPO
23genistein46 30 62 3 25 1214.3CXCL10, TG, TPO
24creatinine469.2CXCL10, TG, TPO
25adenylate469.2TPO, TG, CXCL10
26cycloheximide469.2CXCL10, TG, TPO
27tyrosine468.0CXCL10, TG, TPO, AIRE

GO Terms for genes affiliated with Autoimmune Thyroiditis

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17Gene Ontology
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Cellular components related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7CXCL11, CXCL10, TG, TPO

Biological processes related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.9CXCL11, CXCL10
2T cell chemotaxisGO:0108189.9CXCL11, CXCL10
3positive regulation of cAMP-mediated signalingGO:0439509.8CXCL11, CXCL10
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8CXCL10, CXCL11
5chemokine-mediated signaling pathwayGO:0700989.7CXCL11, CXCL10
6chemotaxisGO:0069359.7CXCL11, CXCL10
7hormone biosynthetic processGO:0424469.7TPO, TG
8thyroid hormone generationGO:0065909.6TG, TPO
9regulation of cell proliferationGO:0421279.4CXCL11, CXCL10
10immune responseGO:0069558.8AIRE, CXCL10, CXCL11

Molecular functions related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.7CXCL11, CXCL10
2CXCR3 chemokine receptor bindingGO:0482489.4CXCL11, CXCL10

Products for genes affiliated with Autoimmune Thyroiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autoimmune Thyroiditis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet