MCID: ATM003
MIFTS: 67

Autoimmune Thyroiditis malady

Rare diseases, Endocrine diseases, Immune diseases categories
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Summaries for Autoimmune Thyroiditis

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NIH Rare Diseases:42 Hashimoto’s syndrome is a form of chronic inflammation of the thyroid gland. the inflammation results in damage to the thyroid gland and reduced thyroid function or “hypothyroidism,” meaning the gland doesn’t make enough thyroid hormone for the needs of the body. symptoms of hashimoto’s syndrome may include goiter, a feeling of fullness in the throat, tiredness, weight gain, cold intolerance, and a slowed heart rate. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it commonly appears between age 40 and age 60. a person with hashimoto’s syndrome may not always need treatment. when it is needed, the condition is treated with synthetic thyroid hormone. last updated: 12/15/2010

MalaCards based summary: Autoimmune Thyroiditis, also known as hashimoto thyroiditis, is related to thyroiditis and hypothyroidism. An important gene associated with Autoimmune Thyroiditis is HT (Hashimoto thyroiditis), and among its related pathways are Immune response Bacterial infections in normal airways and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions. The drugs thyroglobulin and thyroid (usp) and the compounds tarc and ccl3 have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and t cells, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Genetics Home Reference:21 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Wikipedia:65 Autoimmune thyroiditis, (or Chronic Autoimmune thyroiditis), is a disease in which the body interprets... more...

Aliases & Classifications for Autoimmune Thyroiditis

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Autoimmune Thyroiditis, Aliases & Descriptions:

Name: Autoimmune Thyroiditis 8 42 21 10 62
Hashimoto Thyroiditis 8 9 22 21 46
Chronic Lymphocytic Thyroiditis 8 42 21 62
Lymphocytic Thyroiditis 8 21 62
Hashimoto's Syndrome 8 42 62
Hashimoto's Disease 8 42 21
Hashimoto Disease 21 62
Autoimmune Chronic Lymphocytic Thyroiditis 21
Thyroiditides, Chronic Lymphocytic 62
 
Chronic Lymphocytic Thyroiditides 21
Hashimoto's Thyroiditis 8
Hashimotos Thyroiditis 44
Thyroiditis, Chronic 42
Thyroiditis Chronic 44
Hashimoto's Struma 42
Hashimoto Syndrome 21
Hashimoto Struma 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:7188
NCIt39 C27191
ICD1025 E06.2, E06.3

Related Diseases for Autoimmune Thyroiditis

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Diseases in the Autoimmune Thyroiditis family:

Subacute Thyroiditis Acute Thyroiditis
Thyroiditis

Diseases related to Autoimmune Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.6TG, TPO
2hypothyroidism31.4TG, TPO
3celiac disease31.3TPO, TG
4papillary thyroid carcinoma31.0TG, TPO
5vitiligo31.0AIRE, TPO
6hyperthyroidism30.9TG, TPO
7goiter30.9TG, TPO
8hepatitis c30.9CXCL11, CXCL10
9myxedema30.6TG, TPO
10thyrotoxicosis30.6TPO, TG
11type 1 diabetes mellitus30.6AIRE, TPO, TG, CXCL10
12endemic goiter30.6TG, TPO
13turner syndrome30.6TPO, TG
14autoimmune hepatitis30.6AIRE, TPO
15dermatitis30.5CXCL11, CXCL10
16graves' disease30.5AIRE, TPO, TG, CXCL10
17allergic contact dermatitis30.5CXCL11, CXCL10
18subacute thyroiditis30.4TG, TPO
19nodular goiter30.4TG, TPO
20pendred syndrome30.4TPO, TG
21congenital hypothyroidism30.3TG, TPO
22papillary carcinoma30.2TPO, TG
23atherosclerosis30.0CXCL11, CXCL10, TPO
24diabetes mellitus10.7
25hepatitis10.6
26obesity10.5
27subacute lymphocytic thyroiditis10.4
28arthritis10.4
29granuloma annulare10.4
30cryoglobulinemia10.4
31hypothyroidism, autoimmune10.4
32rheumatoid arthritis10.3
33gastritis10.3
34lupus erythematosus10.3
35urticaria10.3
36glomerulonephritis10.3
37systemic lupus erythematosus10.3
38nephrotic syndrome10.3
39thyroid cancer10.3
40autoimmune polyglandular syndrome type 310.3
41pernicious anemia10.3TPO, TG
42toxic diffuse goiter10.3TG, TPO
43mycosis fungoides10.3CXCL10, CXCL11
44plummer's disease10.3TG, TPO
45nontoxic goiter10.3TG, TPO
46multinodular goiter10.3TPO, TG
47thyrotropin deficiency, isolated10.3TG, TPO
48uveitis10.2CXCL11, CXCL10
49follicular thyroid carcinoma10.2TPO, TG
50pregnancy loss10.2TPO, TG

Graphical network of the top 20 diseases related to Autoimmune Thyroiditis:



Diseases related to autoimmune thyroiditis

Symptoms for Autoimmune Thyroiditis

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Drugs & Therapeutics for Autoimmune Thyroiditis

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Thyroiditis

Search NIH Clinical Center for Autoimmune Thyroiditis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Autoimmune Thyroiditis

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Genetic tests related to Autoimmune Thyroiditis:

id Genetic test Affiliating Genes
1 Hashimoto Thyroiditis22

Anatomical Context for Autoimmune Thyroiditis

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MalaCards organs/tissues related to Autoimmune Thyroiditis:

32
Thyroid, T cells, Heart, B cells, Eye, Bone, Lymph node, Breast, Testes, Monocytes, Bone marrow, Brain, Ovary, Whole blood, Salivary gland, Skin, Endothelial, Pituitary, Neutrophil

FMA organs/tissues related to Autoimmune Thyroiditis:

14
Thyroid gl

Animal Models for Autoimmune Thyroiditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Thyroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7ACADS, CXCL10, TG, TPO, AIRE

Publications for Autoimmune Thyroiditis

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Articles related to Autoimmune Thyroiditis:

(show top 50)    (show all 872)
idTitleAuthorsYear
1
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
2
Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis. (25150037)
2014
3
Immunological Characteristics of Children with Hashimoto's Autoimmune Thyroiditis. (25248347)
2014
4
Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. (23253044)
2013
5
A possible association of hypokalaemic periodic paralysis, autoimmune thyroiditis and neuromyotonia. (24385062)
2013
6
Screening of SLC26A4 gene in autoimmune thyroid diseases. (23280318)
2013
7
The misdiagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis as masked depression in an elderly euthyroid woman. (23453127)
2013
8
Ultrasonographic characterization of cervical lymphadenopathy in chronic autoimmune thyroiditis. (23167267)
2013
9
Is autoimmune thyroiditis a risk factor for early atherosclerosis in premenopausal women even if in euthyroid status? (23184180)
2013
10
Xiaoyin recipe ( ) for psoriasis induces a Th1/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats. (22311410)
2012
11
Invariant NKT Cell Lines Derived from the NODA^H2 Mouse Enhance Autoimmune Thyroiditis. (21603172)
2011
12
The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. (21198744)
2011
13
SLC26A4 expression among autoimmune thyroid tissues. (21035230)
2011
14
Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis. (21738252)
2011
15
The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. (20356797)
2010
16
Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases]. (19947439)
2009
17
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. (20134044)
2009
18
Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. (17919982)
2008
19
Altered expression of T lymphocyte surface markers in children with chronic autoimmune thyroiditis. (19218661)
2008
20
Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese. (18058260)
2007
21
Association analysis of interleukin gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (17964974)
2007
22
Antigenic determinants to GAD autoantibodies in patients with type 1 diabetes with and without autoimmune thyroid disease. (17130557)
2006
23
Soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases: relation to humoral immune response markers. (17357290)
2006
24
Incidence of iodine deficiency in patients presenting with goitre--discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis--clinical, hormonal and urinary iodine excretion studies. (16509527)
2006
25
18q deletion syndrome associated with autoimmune thyroid disease presenting as hyperthyroidism. (15844478)
2005
26
Diagnosis of autoimmune thyroid disease]. (16405253)
2005
27
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
28
Consequences of autoimmune thyroiditis before, during and after pregnancy. (14605606)
2003
29
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. (14746804)
2003
30
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
31
Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease. (14679088)
2003
32
Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto's encephalitis? (14616889)
2003
33
Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. (12848996)
2002
34
Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996. (12097200)
2002
35
Etiopathogenesis of autoimmune thyroiditis]. (12635359)
2002
36
Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases. (11217812)
2001
37
Usefulness of screening program for celiac disease in autoimmune thyroiditis. (10711459)
2000
38
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. (11129116)
2000
39
Fine-needle biopsy cytology in autoimmune thyroiditis. (10756865)
1998
40
Somatic hypermutation in autoimmune thyroid disease. (9602367)
1998
41
The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis. (9878080)
1998
42
Autoimmune thyroid disease in patients with type 1 diabetes mellitus]. (9588075)
1998
43
Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population. (9285944)
1997
44
Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. (8938107)
1996
45
Isolation of thyroid peroxidase and lack of autoantibodies to the enzyme in dogs with autoimmune thyroid disease. (7695146)
1995
46
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
47
Deregulated production of interleukin-8 (IL-8) in autoimmune thyroid disease studied by newly developed IL-8 radioimmunoassay. (8003701)
1993
48
The relationship between autoimmune thyroid disease and iodine intake: a review. (1345585)
1992
49
Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. (1829139)
1991
50
Thyroid peroxidase/microsomal antibodies are not identical with thyroid cytotoxic antibodies in autoimmune thyroiditis. (2239089)
1990

Variations for Autoimmune Thyroiditis

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Expression for genes affiliated with Autoimmune Thyroiditis

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Expression patterns in normal tissues for genes affiliated with Autoimmune Thyroiditis

Search GEO for disease gene expression data for Autoimmune Thyroiditis.

Pathways for genes affiliated with Autoimmune Thyroiditis

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Compounds for genes affiliated with Autoimmune Thyroiditis

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Compounds related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1tarc449.9CXCL11, CXCL10
2ccl344 2810.9CXCL11, CXCL10
3ccl444 2810.9CXCL10, CXCL11
4iodotyrosine44 2410.9TG, TPO
5diiodotyrosine449.9TG, TPO
6perchlorate449.9TG, TPO
7sodium iodide449.8TG, TPO
8propylthiouracil44 2 1111.8TPO, TG
9gliadin449.8TG, TPO
10chromium449.8TG, TPO
11iodine44 2410.8TG, TPO
12amiodarone44 50 28 1112.8TPO, TG
13125i449.8TG, TPO
14iodide44 2410.8TG, TPO
15cardiolipin44 1110.8TG, TPO
16methimazole44 2 1111.8TPO, TG
17selenium44 2410.7TG, TPO
18triiodothyronine449.5TG, TPO
19sodium dodecylsulfate449.5TG, TPO
20hydrocortisone44 2 61 1112.5TPO, TG, CXCL10
21suramin44 28 1111.4TG, CXCL10
22gold449.4CXCL10, TG, TPO
23genistein44 28 61 2 24 1114.3CXCL10, TG, TPO
24creatinine449.2CXCL10, TG, TPO
25adenylate449.2TPO, TG, CXCL10
26cycloheximide449.2CXCL10, TG, TPO
27tyrosine448.0CXCL10, TG, TPO, AIRE

GO Terms for genes affiliated with Autoimmune Thyroiditis

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Cellular components related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7CXCL11, CXCL10, TG, TPO

Biological processes related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:0308169.9CXCL11, CXCL10
2T cell chemotaxisGO:0108189.9CXCL11, CXCL10
3positive regulation of cAMP-mediated signalingGO:0439509.8CXCL11, CXCL10
4positive regulation of release of sequestered calcium ion into cytosolGO:0512819.8CXCL10, CXCL11
5chemokine-mediated signaling pathwayGO:0700989.7CXCL11, CXCL10
6chemotaxisGO:0069359.7CXCL11, CXCL10
7hormone biosynthetic processGO:0424469.7TPO, TG
8thyroid hormone generationGO:0065909.6TG, TPO
9regulation of cell proliferationGO:0421279.4CXCL11, CXCL10
10immune responseGO:0069558.8AIRE, CXCL10, CXCL11

Molecular functions related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.7CXCL11, CXCL10
2CXCR3 chemokine receptor bindingGO:0482489.4CXCL11, CXCL10

Products for genes affiliated with Autoimmune Thyroiditis

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Sources for Autoimmune Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet