Autoimmune Thyroiditis malady

Disease Ontology: An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.⁶

MalaCards: Autoimmune Thyroiditis, also known as hashimoto thyroiditis, is related to papillary thyroid carcinoma and hypothyroidism. An important gene associated with Autoimmune Thyroiditis is ZFAT (zinc finger and AT hook domain containing), and among its related pathways are Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway and Immune response IFN alpha/beta signaling pathway. The drugs thyroglobulin and levothyroxine and the compounds cholesterol and rituximab have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, whole blood and brain, and related mouse phenotypes are growth/size and mortality/aging.

Wikipedia: Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis, is a disease in which the body interprets the...⁴⁴ more...

Aliases & Descriptions:

autoimmune thyroiditis 6 8 43 hashimoto thyroiditis 6 7 33 chronic lymphocytic thyroiditis 6 hashimoto's thyroiditis 6 lymphocytic thyroiditis 6

hashimotos thyroiditis 32 hashimoto's syndrome 6 hashimoto's disease 6 hashimoto disease 43 thyroiditis 43

Diseases related to autoimmune thyroiditis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1200)

id	Related Disease	Score	Top Affiliating Genes
1	papillary thyroid carcinoma	34.5	RET, CALCA, ESR2, TXNRD2, TPO, TSHR
2	hypothyroidism	34.4	IGFBP3, IFNA1, IFNA2, IFNB1, GHRL, TRH
3	congenital hypothyroidism	33.9	SERPINA7, CALCA, TPO, TNF, CYP21A2, SHBG
4	thyroid adenoma	33.9	RET, SERPINA7, BCL2, ITGB2, FLNB, TXNRD2
5	thyroid hormone resistance syndrome	33.6	SERPINA7, TXNRD2, TRH, SHBG, THRB, TG
6	follicular adenoma	33.0	RET, LMOD1, AR, CALCA, TPO, DIO2
7	hypothyroidism, autoimmune	32.8	IL2RA, AIRE, TPO, CTLA4, CXCL11, CXCL9
8	addison's disease	32.7	FOXP3, INS, FCGR3B, AIRE, HLA-A, HLA-B
9	multiple endocrine neoplasia	32.6	RET, INS, MBL2, IGFBP3, IFNA1, CALCA
10	anaplastic carcinoma	32.3	RET, CALCA, TPO, TSHR, TG
11	generalized resistance to thyroid hormone	32.2	TXNRD2, TRH, THRB, PRL
12	hepatitis	32.2	GZMB, IL2RB, FASLG, FAS, CCL20, IFNA1
13	celiac disease	32.2	IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1, TNF, CTLA4
14	multinodular goiter	31.7	IL1A, IL1B, IFNG, CALCA, ESR2, HLA-C
15	type 1 diabetes mellitus	31.7	SERPINA7, SEL1L, CD69, INS, IL12B, IL15
16	subacute thyroiditis	31.5	TPO, TSHR, TG
17	thyroid medullary carcinoma	31.5	RET, GZMB, IL2, FASLG, FAS, CALCA
18	rheumatoid arthritis	31.5	IL1RN, MBL2, HLA-DRB1, TNFRSF1A, SRF, LTA
19	thyroid cancer, follicular	31.5	CALCA, TSHR, THRB, TG
20	systemic lupus erythematosus	30.9	FOXP3, FASLG, MBL2, PTPN22, CTLA4
21	thyroid cancer	30.7	RET, CALCA, TPO, TSHR, TG
22	endemic goiter	30.5	SERPINA7, IGFBP3, TRH, TPO, TSHR, TG
23	turner syndrome	30.5	SERPINA7, CGA, IGFBP3, TPO, CYP21A2, SRY
24	nontoxic goiter	30.4	FASLG, TRH, TPO, TSHR, TG
25	myxedema	30.1	LGR6, TPO, CTLA4, TSHR, TG
26	nodular goiter	30.0	IFNG, ICAM1, CALCA, TRH, TPO, TSHR
27	pituitary tumor	30.0	ENO1, ESR1, ESR2, GHRL, TXNRD2, TRH
28	thyroid cancer, anaplastic	29.9	RET, CALCA, TP53, TPO, TSHR, TG
29	empty sella syndrome	29.9	INS, IGFBP3, TRH, PRL
30	hepatitis c	29.6	CD28, CD69, CD40LG, IL10, IL12B, IL18
31	arthritis	29.4	IL1A, IL1B, IL6, IL8, TNF, TNFRSF1A
32	neonatal hypothyroidism	29.4	TPO, TSHR, TG, SLC5A5
33	small cell carcinoma	29.4	BCL2, ITGAL, INS, APOH, FASLG, FAS
34	hyperthyroxinemia	29.2	SERPINA7, TRH, TPO, TSHR, THRB, PRL
35	stiff-person syndrome	29.1	INS, AMPH, GAD1, GAD2
36	cystic echinococcosis	29.1	IL12B, IL2RA, HLA-B, HLA-DRB1, TAP1, TAP2
37	thyrotoxicosis	29.0	LMOD1, CGA, INS, IL2, IL2RA, IFNA1
38	polycystic ovary syndrome	28.7	CGA, AR, INS, IGFBP3, GHRL, CYP21A2
39	lung carcinoma	28.7	BCL2, CD59, CD40, FOXP3, GZMB, FAS
40	autoimmune myocarditis	28.6	ITGB2, IL2, CCL2, IFNG, ICOS, TNF
41	hepatitis b	28.6	CD40, IL10, IL12B, IL18, IL2RA, MBL2
42	endogenous depression	28.5	INS, TRH, TPO, TG, PRL
43	thyroid hormone metabolism	28.5	SEPP1, LMOD1, INS, IL1B, IL6, TPO
44	multiple sclerosis	28.4	CD40, IL1A, IL1B, IL1RN, IL2RA, IFNG
45	renal cell carcinoma	28.4	RET, CD86, CD59, CD80, CD40, IL13
46	hypoparathyroidism	28.4	PIK3C2A, RET, INS, IL2RA, CALCA, AIRE
47	hyperthyroidism	28.1	PIK3C2A, SELE, SERPINA7, LMOD1, CGA, MPO
48	folliculitis	28.1	IL2RA, IL4, IL5, CCL5, IFNG, HLA-DQB1
49	squamous cell carcinoma	27.9	SEL1L, BMP6, BCL2, CD86, CD59, ITGB2
50	breast cancer	27.9	BMP6, CD80, AR, ESR1, ESR2, ACP1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 levothyroxine, levothyroxine sodium, liothyronine, liothyronine sodium, thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

MalaCards organs/tissues related to autoimmune thyroiditis:

²²

FMA organs/tissues related to autoimmune thyroiditis:

¹¹

MGI Mouse Phenotypes related to autoimmune thyroiditis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	PTPN3, PTPN22, , TPO, TP53, TRH
2	mortality/aging	MP:0010768	INF	IL2RB, TXNRD2, TP53, TPO, TNFRSF1A, PTPN22
3	digestive/alimentary phenotype	MP:0005381	INF	ESR1, ESR2, GHRL, AIRE, DIO2, CTLA4
4	homeostasis/metabolism phenotype	MP:0005376	INF	CD40LG, IL5, APOH, FASLG, FAS, MBL2
5	integument phenotype	MP:0010771	INF	TP53, TNFRSF1A, TNFRSF1B, CTLA4, ACADS, TAP1
6	behavior/neurological phenotype	MP:0005386	INF	ACADS, LTA, SRF, TNFRSF1B, TNFRSF1A, HLA-DQB1
7	hematopoietic system phenotype	MP:0005397	INF	SERPINB1, , ZFAT, BCL2, CD28, CD69
8	respiratory system phenotype	MP:0005388	INF	SRF, THRB, ADA, GAD1, GAD2, PTPN22
9	vision/eye phenotype	MP:0005391	INF	IFNG, ICAM1, AIRE, TP53, TNF, TNFRSF1A
10	renal/urinary system phenotype	MP:0005367	8.7	TNFRSF1B, DIO2, CYP27B1, ACADS, SLC26A4, ESR2
11	no phenotypic analysis	MP:0003012	7.9	GHRL, AIRE, HLA-C, TXNRD2, TP53, PTPN3
12	adipose tissue phenotype	MP:0005375	6.3	ESR2, GHRL, TP53, TNF, TNFRSF1A, TNFRSF1B
13	muscle phenotype	MP:0005369	6.1	TNFRSF1B, TNFRSF1A, TNF, TP53, TXNRD2, SRF
14	cellular phenotype	MP:0005384	INF	HLA-C, CTLA4, LTA, ACADS, ACP1, TSHR
15	reproductive system phenotype	MP:0005389	INF	IL15, IL1RN, IL2RB, IL4, IL6, FASLG
16	skeleton phenotype	MP:0005390	INF	PTPN3, TNFRSF1B, TNFRSF1A, TP53, ESR2, CYP27B1
17	immune system phenotype	MP:0005387	INF	SERPINB1, HSPA1B, AIRE, HLA-C, HLA-DQA1, HLA-DQB1
18	cardiovascular system phenotype	MP:0005385	INF	TNF, TP53, TXNRD2, HLA-DQB1, ESR2, ESR1
19	tumorigenesis	MP:0002006	INF	BCL2, ITGAL, GZMB, AR, IL10, IL12B
20	nervous system phenotype	MP:0003631	INF	TG, THRB, TLR3, TSHR, LTA,
21	endocrine/exocrine gland phenotype	MP:0005379	INF	RET, SEL1L, CD40LG, IL2, IL2RB, FASLG
22	normal phenotype	MP:0002873	INF	TXNRD2, HLA-DQB1, AIRE, GHRL, ESR2, TP53
23	liver/biliary system phenotype	MP:0005370	INF	TXNRD2, TP53, PTPN22, CTLA4, ACADS, PRL

Articles related to autoimmune thyroiditis:

(show top 50)    (show all 351)

id	Title	Authors	Year	Affiliating Genes
1	The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. (20356797)	Potlukova E.... Trendelenburg M.	2010	MBL2
2	Association of functional polymorphisms related to th e transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. (20942809)	Inoue N.... Iwatani Y.	2010	FOXP3
3	Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity. (20825955)	Moriguchi M.... Ikegami H.	2010	CTLA4, HLA-DQB1, HLA-DRB1
4	Interleukin 6 -174(G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children. (18692934)	Mysliwiec M.... Wisniewski P.	2008	IL6
5	Increased incidence of autoimmune thyroiditis in patients with antipsychotic-induced hyperprolactinemia. (18539008)	Poyraz B.C.... BalcioA9lu I.	2008	PRL
6	Circulating chemokines in patients with autoimmune thyroid diseases. (18415893)	Domberg J.... Schott M.	2008	CCL5, CXCL10, CXCL9
7	The +869T/C polymorphism in the transforming growth factor-beta1 gene is associated with the severity and intractability of autoimmune thyroid disease. (18190611)	Yamada H.... Iwatani Y.	2008	TGFB1
8	AIRE gene polymorphisms in systemic sclerosis associated with autoimmune thyroiditis. (17101293)	Ferrera F.... Indiveri F.	2007	AIRE
9	By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. (16916620)	Arata N.... Davies T.F.	2006	TG
10	Stress and autoimmune thyroid diseases. (17709953)	Bagnasco M.... Pesce G.	2006	TSHR
11	Smoking and autoimmune thyroid disease: the plot thic kens. (16728534)	Krassas G.E.... Wiersinga W.	2006	TPO
12	Susceptibility genes for the development of autoimmune thyroid disease (17154080)	Shirasawa S.	2006	CTLA4, FCRL3
13	The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. (16352685)	Ikegami H.... Ogihara T.	2006	CTLA4, HLA-DQB1, HLA-DRB1
14	Autoimmune thyroiditis and exposure to iodine 131 in the Ukrainian cohort study of thyroid cancer and other thyroid diseases after t he Chornobyl accident: results from the first screening cycle (1998-2000). (16912122)	Tronko M.D.... Howe G.R.	2006	TPO
15	Autoimmune thyroid disease--clinical symptoms of associated autoimmunity (16405252)	Djurica S.... MarkoviA8 N.	2005	TG
16	The codon 620 single nucleotide polymorphism of the protein tyrosine phosphatase-22 gene does not contribute to autoimmune thyroid disease susceptibility in the Japanese. (16279843)	Ban Y.... Ban Y.	2005	PTPN22
17	Association of antipituitary antibody and type 2 iodothyronine deiodinase antibody in patients with autoimmune thyroid disease. (16410660)	Nakahara R.... Murakami M.	2005	DIO2
18	High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism. (15531503)	Antonelli A.... Serio M.	2004	CXCL10
19	Quantitative thyroid scintigraphy for the differentiation of Graves' disease and hyperthyroid autoimmune thyroiditis. (15316579)	Sahlmann C.O.... Meller J.	2004	TPO
20	Autoantibodies in autoimmune thyroid disease promote immune complex formation with self antigens and increase B cell and CD4+ T cell proliferation in response to self antigens. (14971052)	Nielsen C.H.... Leslie R.G.	2004	TG
21	Analysis of MHC genes in a Tunisian isolate with autoimmune thyroid diseases: implication of TNF -308 gene polymorphism. (15236755)	Bougacha-Elleuch N.... Hammadi A.	2004	TNF, HLA-A, LTA
22	Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. (12759428)	Vasu C.... Prabhakar B.S.	2003	FLT3LG
23	Familial aggregation of autoimmune thyroiditis in fir st-degree relatives of patients with juvenile autoimmune thyroid disease. (12729480)	Marwaha R.K.... Jain S.K.	2003	TPO
24	Analysis of the CTLA-4, CD28, and inducible costimulator (ICOS) genes in autoimmune thyroid disease. (14647199)	Ban Y.... Tomer Y.	2003	CTLA4, ICOS
25	Etiopathogenesis of autoimmune thyroiditis (12635359)	PleA9a C.... Zugun F.	2002	TG
26	Large multifunctional proteasome 2 gene Arg60His vari ant in autoimmune thyroid disease in Shanghai Chinese. (12189117)	Ding H.... et al .	2002	PSMB9
27	Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. (12848996)	Tomer Y.	2002	CTLA4, TG
28	CTLA-4 and autoimmune thyroid disease: lack of influence of the A49G signal peptide polymorphism on functional recombinant human CTLA-4. (12202150)	Xu Y.... Davies T.F.	2002	CTLA4
29	Autoimmune thyroid disease induced by thyroglobulin and lipopolysaccharide is inhibited by soluble TNF receptor type I. (11920568)	Zaccone P.... Cooke A.	2002	TNFRSF1A
30	Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases. (11217812)	Freire B.A.... Queluz T.T.	2001	TPO, SERPINB1
31	New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. (11129116)	Kong Y.C.... David C.S.	2000	PRSS3
32	Autoimmune thyroid diseases complicated with reversible changes of thyroid function (10483247)	Kajita Y.... Ochi Y.	1999	CGA
33	Genetic and environmental factors of autoimmune thyroid diseases (10483236)	Akamizu T.	1999	CTLA4
34	Apoptosis in the pathogenesis of autoimmune thyroid disease (10483239)	Abe Y.	1999	FAS
35	Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease. (10323395)	Jaume J.C.... McLachlan S.M.	1999	TPO
36	Induction of oral tolerance in human autoimmune thyroid disease. (9545109)	Lee S.... DeGroot L.J.	1998	TG
37	A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease. (9837828)	Tomer Y.... Davies T.F.	1998	GRD2
38	Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis: role of MHC class II. (9344702)	Wan Q.... Kong Y.M.	1997	TG
39	Thyroid stimulating hormone receptor antibody levels in Singaporean patients with autoimmune thyroid disease. (9395805)	Khoo D.H.... Ho S.C.	1997	TSHR
40	HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene. (9064334)	Kong Y.C.... David C.S.	1996	TG
41	Majority of thyroid peroxidase autoantibodies in patients with autoimmune thyroid disease are directed to a single TPO domain. (8879450)	Czarnocka B.... Gardas A.	1996	TPO
42	The effect of soluble complement receptor 1 (sCR1) and human thyroid antibodies on the course of experimental autoimmune thyroiditis in rats. (8871757)	Metcalfe R.A.... Weetman A.P.	1996	TPO
43	Autoantibodies to glutamic acid decarboxylase in patients with autoimmune thyroid disease: relation to competitive insulin autoantibodies. (8579720)	Kawasaki E.... Akazawa S.	1995	GAD1, INS
44	Development of autoimmune thyroid diseases during long-term treatment of hematological malignancies with alpha-interferons. (7806093)	Silvestri F.... Baccarani M.	1994	IFNA1
45	Importance of gamma-interferon and DR expression in autoimmune thyroid disease (8191131)	Aguayo J.... Pineda G.	1993	IFNG
46	Study of induction of activation of human peripheral blood mononuclear cells with a non-activating form of anti-CD3 MoAb in autoimmune thyroid disease (AITD). (8443962)	Resetkova E.... VolpAc R.	1993	IL2, TPO, TG
47	Effect of human thyroglobulin on the production of platelet activating factor from peripheral blood mononuclear cells from patients with autoimmune thyroid diseases. (1476872)	Resetkova E.... VolpAc R.	1992	TG
48	Chronic autoimmune thyroiditis and C-cell hyperplasia. Study of calcitonin secretion in 24 patients (1929193)	Barbot N.... Bigorgne J.C.	1991	CALCA
49	Thyroid autoimmunity and thyroid autonomy. (2202187)	Vitti P.... Pinchera A.	1990	TPO
50	CD4+ T-cell clones from autoimmune thyroid tissue cannot be classified according to their lymphokine production. (1980155)	Grubeck-Loebenstein B.... Feldmann M.	1990	TNF, IL6, IL2

Genes related to autoimmune thyroiditis according to GeneCards:

(show top 50)    (show all 168)

id	Symbol	Description	Score	GeneCards Section Context
1	ZFAT	zinc finger and AT hook domain containing	11.1	Summaries, Aliases & Descriptions, Publications
2	TG	thyroglobulin	11.1	Publications, Pathways & Interactions, Summaries
3	AITD2	Autoimmune thyroid disease, susceptibility to, 2	11.1	Publications, Aliases & Descriptions
4	AITD4	Autoimmune thyroid disease, susceptibility to, 4	11.1	Aliases & Descriptions
5	AITD1	Autoimmune thyroid disease, susceptibility to, 1	11.1	Aliases & Descriptions
6	FCRL3	Fc receptor-like 3	11.1	Summaries, Publications
7	ZFAT-AS1	ZFAT antisense RNA 1	11.0	Publications, Summaries
8	TPO	thyroid peroxidase	11.0	Pathways & Interactions, Publications
9	TSHR	thyroid stimulating hormone receptor	11.0	Pathways & Interactions, Publications
10	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Pathways & Interactions, Publications
11	AIRE	autoimmune regulator	11.0	Publications
12	LMOD1	leiomodin 1 (smooth muscle)	11.0	Publications
13	SLC26A4	solute carrier family 26, member 4	11.0	Publications
14	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
15	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
16	LGR6	leucine-rich repeat containing G protein-coupled receptor 6	11.0	Publications
17	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
18	TXNRD2	thioredoxin reductase 2	11.0	Publications
19	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Pathways & Interactions, Publications
20	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0	Publications
21	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
22	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Pathways & Interactions, Publications
23	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications, Pathways & Interactions
24	HSPA1A	heat shock 70kDa protein 1A	11.0	Publications
25	IL15	interleukin 15	11.0	Publications
26	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
27	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
28	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Pathways & Interactions, Publications
29	CXCL13	chemokine (C-X-C motif) ligand 13	11.0	Publications
30	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
31	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications, Pathways & Interactions
32	GAST	gastrin	11.0	Publications
33	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
34	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications
35	IFNA1	interferon, alpha 1	11.0	Pathways & Interactions, Publications
36	ICAM1	intercellular adhesion molecule 1	11.0	Publications
37	IFNG	interferon, gamma	11.0	Publications
38	THRB	thyroid hormone receptor, beta	11.0	Publications
39	HT	Hashimoto thyroiditis	11.0	Publications
40	GRD2	Graves disease, susceptibility to, 2	11.0	Publications
41	PRSS3	protease, serine, 3	11.0	Publications
42	IFNA10	interferon, alpha 10	11.0	Pathways & Interactions
43	IFNA6	interferon, alpha 6	11.0	Pathways & Interactions
44	IFNA5	interferon, alpha 5	11.0	Pathways & Interactions
45	IFNA4	interferon, alpha 4	11.0	Pathways & Interactions
46	IFNA16	interferon, alpha 16	11.0	Pathways & Interactions
47	IFNA14	interferon, alpha 14	11.0	Pathways & Interactions
48	IFNA8	interferon, alpha 8	11.0	Pathways & Interactions
49	IFNA13	interferon, alpha 13	11.0	Pathways & Interactions
50	ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	11.0	Publications

Pathways related to autoimmune thyroiditis according to GeneDecks:

(show top 50)    (show all 151)

id	Pathway	Score	Top Affiliating Genes
1	Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway41	10.8	IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
2	Immune response IFN alpha/beta signaling pathway10	10.8	IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
3	Interferon Pathway36	10.7	IL6, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16
4	CTLA4 Signaling36	10.7	CD28, CD86, CD80, HLA-DMA, HLA-DMB, HLA-DOA
5	G-protein signaling_N-RAS regulation pathway41	10.7	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
6	TCR Signaling36	10.6	CD28, CD86, CD80, HLA-DMA, HLA-DMB, HLA-DOA
7	Innate Immune System38	10.5	BCL2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16
8	Immune response Antigen presentation by MHC class II10	10.5	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
9	Calcium Mediated T-Cell Apoptosis36	10.5	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DQA1
10	Antigen processing and presentation20	10.5	HSPA1A, HSPA1B, HSPA1L, HLA-C, HLA-DMA, HLA-DMB
11	Immune response_Antigen presentation by MHC class II41	10.4	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
12	Cell adhesion molecules (CAMs)20	10.4	CD28, CD86, CD80, CD40, ITGAL, ITGB2
13	IL-4 Pathway36	10.3	BCL2, IL4, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB
14	RAR-Gamma-RXR-Alpha Degradation36	10.3	CD80, IL15, IL2, CCL20, CCL17, CCL5
15	CDC42 Pathway36	10.3	ITGAL, ITGB2, HLA-A, HLA-B, HLA-C, HLA-DMA
16	CTL Mediated Apoptosis36	10.2	GZMB, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB
17	ICos-ICosL Pathway in T-Helper Cell36	10.2	PIK3C2A, CD28, CD86, CD80, IL2, IL2RA
18	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.1	BCL2, GZMB, IL15, IL2, IL2RA, IL2RB
19	Immune response IL-22 signaling pathway10	9.9	BCL2, CD28, CD86, IL12B, IL2, IL2RA
20	Immune response_IL-22 signaling pathway41	9.9	BCL2, CD28, CD86, IL12B, IL2, IL2RA
21	Graft-versus-host disease20	9.7	CD28, CD86, CD80, IL1A, IL2, FASLG
22	Regulation of eIF4 and p70S6K36	9.7	CD80, ITGAL, ITGB2, IL12B, IL13, IL15
23	Jak-STAT signaling pathway20	9.4	IL10, IL12B, IL13, IL15, IL2, IL23R
24	IL-6 Pathway36	9.4	BMP6, CD80, IL10, IL12B, IL18, IL4
25	Toll-like receptor signaling pathway20	9.4	CD86, CD80, CD40, IL12B, IL1B, IL6
26	Toxoplasmosis20	9.1	BCL2, CD40LG, CD40, IL10, IL12B, IFNG
27	Autoimmune thyroid disease20	9.1	CGA, CD28, CD86, CD40LG, CD80, CD40
28	THC Differentiation Pathway36	9.0	CD28, CD86, IL10, IL12B, IL18, IL2
29	Asthma20	8.9	CD40LG, CD40, IL10, IL13, IL4, IL5
30	NFAT Signaling and Lymphocyte Interactions36	8.7	BMP6, BCL2, CD80, IL12B, IL13, IL15
31	Endothelin-1 Signaling Pathway36	8.3	BMP6, CD80, IL10, IL12B, IL13, IL18
32	PGC1Alpha Pathway36	8.3	BMP6, BCL2, CD80, IL12B, IL13, IL15
33	Malaria20	8.0	SELE, VCAM1, CD40LG, CD40, ITGAL, ITGB2
34	Type I diabetes mellitus20	7.9	CD28, CD86, CD80, GZMB, INS, IL12B
35	SOCS Pathway36	7.4	BMP6, BCL2, CD80, INS, IL10, IL12B
36	Molecular Mechanisms of Cancer36	7.3	BMP6, BCL2, CD80, ITGAL, ITGB2, IL12B
37	Glucocorticoid Receptor Signaling36	7.3	BMP6, BCL2, CD80, IL10, IL12B, IL13
38	Tec Kinases Signaling36	7.2	BMP6, BCL2, CD28, CD80, ITGAL, ITGB2
39	MIF Mediated Glucocorticoid Regulation36	7.1	BMP6, BCL2, CD80, IL10, IL12B, IL13
40	MIF Regulation of Innate Immune Cells36	7.1	BMP6, BCL2, CD80, IL10, IL12B, IL13
41	PEDF Induced Signaling36	7.1	BMP6, BCL2, CD80, IL10, IL12B, IL13
42	ERK Signaling36	7.0	BMP6, CD80, ITGAL, ITGB2, IL10, IL12B
43	TGF-Beta Pathway36	7.0	BMP6, BCL2, CD80, IL10, IL12B, IL13
44	PAK Pathway36	6.6	BMP6, BCL2, CD80, IL10, IL12B, IL13
45	JAK-STAT Pathway36	6.5	BMP6, BCL2, CD80, IL10, IL12B, IL13
46	p38 Signaling36	5.4	BMP6, BCL2, CD28, CD80, IL10, IL12B
47	Natural killer cell mediated cytotoxicity20	INF	ITGAL, ITGB2, GZMB, , IFNA1, IFNA10
48	Leishmaniasis20	INF	ITGB2, , IL10, IL12B, IL1A, IL1B
49	Tuberculosis20	INF	BCL2, ITGB2, , IL10, IL12B, IL18
50	Systemic lupus erythematosus20	INF	CD28, CD86, CD40LG, CD80, CD40,

Compounds related to autoimmune thyroiditis according to GeneDecks:

(show top 50)    (show all 438)

id	Compound	Score	Top Affiliating Genes
1	cholesterol32 9 18 9	INF	PIK3C2A, LRP2, SELE, SERPINA7, VCAM1, LGR6
2	rituximab32 34 9 9	INF	BCL2, , CD40LG, CD80, CD40,
3	lactate32	INF	PIK3C2A, SELE, VCAM1, BMP6, CGA, MPO
4	superoxide32 18	INF	PIK3C2A, SERPINB1, VCAM1, MPO, , CD40
5	ionomycin32	10.9	CD69, CD40, IL5, TNFRSF1A, TSHR
6	ivig32	10.8	PIK3C2A, FASLG, IFNB1, LTA, TG
7	cyclophosphamide32 34 9 9	13.6	ITGAL, ITGB2, FLT3LG, APOH, MBL2, CXCL9
8	methimazole32 9 9	12.1	SELE, SERPINA7, CD69, IL13, IL2RA, APOH
9	rapamycin32 42	10.8	CD86, CD80, FOXP3, GZMB, AR, INS
10	hyaluronic acid32 18	10.7	BMP6, ITGAL, ITGB2, GZMB, IL13, FASLG
11	vitamin a32 9 18 9	12.6	LRP2, RET, SERPINA7, CGA, AR, FAS
12	dopamine32 9 18 9	12.6	RET, SELE, LMOD1, BMP6, CGA, CD40LG
13	n acetylcysteine32	9.2	SELE, VCAM1, CD40, AR, IL18, IL2RA
14	acetylcholine32 9 18 9	12.0	PIK3C2A, BMP6, CGA, MPO, CD40LG, IL13
15	ifn-alpha32	8.8	IL10, IL13, IL18, IL2, IL2RA, IL2RB
16	erythromycin32 9 9	10.7	PIK3C2A, VCAM1, MPO, CD40LG, ITGB2, IL13
17	poly(i-c)32	8.6	VCAM1, CD69, IL12B, IL15, IL18, IL1B
18	thalidomide32 42 9 9	11.6	CD40LG, ITGB2, IL10, IL18, IL1B, IL2
19	epinephrine32 9 18 9	11.6	PIK3C2A, SELE, BMP6, CGA, CD69, INS
20	okt332	8.4	SELE, VCAM1, BMP6, CD40LG, ITGB2, IL10
21	sb 20358032 42	9.4	SELE, VCAM1, BMP6, BCL2, ITGB2, IL13
22	imiquimod32 42 9 9	11.3	BMP6, IL10, IL12B, IL18, IL1A, IL5
23	fluticasone propionate32 42 9 9	11.2	SELE, VCAM1, MPO, IL13, IL1B, IL4
24	adenylate32	8.2	SELE, VCAM1, LGR6, CGA, CD40LG, CD40
25	testosterone32 9 18 9	11.0	PIK3C2A, RET, SELE, SERPINA7, SEPP1, VCAM1
26	ccl332	8.0	IL10, IL13, IL15, IL18, IL1A, IL1B
27	5fluorouracil32	8.0	SELE, BCL2, MPO, IL15, IL18, IL2
28	histamine32 18	8.9	SELE, VCAM1, BMP6, CGA, MPO, CD86
29	polymyxin b32	7.8	SELE, VCAM1, ITGB2, IL10, IL1A, IL1B
30	retinoid32	7.7	BMP6, BCL2, ITGB2, AR, IL2RB, IGFBP3
31	ly29400232	7.6	PIK3C2A, RET, SELE, CD69, ITGB2, GZMB
32	tacrolimus32 34 9 9	10.5	BMP6, CD28, CD69, CD86, CD40, ITGAL
33	prostacyclin32	7.5	PIK3C2A, SELE, VCAM1, BMP6, CGA, IL10
34	rantes32	7.5	SELE, VCAM1, BMP6, CD40LG, CD40, ITGAL
35	cisplatin32 34 9 9	10.3	PIK3C2A, BMP6, BCL2, CGA, MPO, CD40LG
36	ribonucleic acid32	7.2	RET, SERPINA7, BMP6, CGA, CD40, GZMB
37	vitamin d32	6.9	LRP2, BMP6, CGA, ITGB2, AR, IL10
38	indomethacin32 9 9	8.9	BMP6, CGA, MPO, CD40LG, CD40, ITGB2
39	il 1032	6.9	BMP6, CD40, IL10, IL12B, IL13, IL15
40	methotrexate32 34 42 9 9	10.5	PIK3C2A, SELE, BMP6, CGA, CD69, CD40
41	paraffin32	6.3	RET, VCAM1, BCL2, CGA, MPO, CD40LG
42	tamoxifen32 34 9 9	9.1	SELE, SERPINA7, VCAM1, BMP6, BCL2, CGA
43	actinomycin d32	5.1	SELE, BCL2, CGA, CD69, CD40LG, CD40
44	vegf32	4.9	PIK3C2A, RET, SELE, VCAM1, BCL2, CGA
45	cysteine32	INF	SEPP1, LMOD1, LILRB1, CD40LG, CD40, GZMB
46	polysaccharide32	INF	SELE, VCAM1, BMP6, CD69, CD40LG, ITGB2
47	progesterone32 42 9 18 9	INF	SERPINA7, BCL2, CGA, AR, HSPA1A, ESR1
48	leukotriene b432 42 18	INF	MPO, ITGAL, ITGB2, , IL13, IL1A
49	phosphatidylinositol32	INF	PIK3C2A, RET, VCAM1, BMP6, BCL2, CD28
50	prednisolone32 9 9	INF	PIK3C2A, VCAM1, BMP6, MPO, CD40, ITGAL

Cellular components related to autoimmune thyroiditis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	10.6	HLA-DRB5, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DRB4, HLA-DRB3
2	clathrin-coated endocytic vesicle membrane	GO:030669	10.5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA, HLA-DQB1
3	trans-Golgi network membrane	GO:032588	10.5	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
4	lysosomal membrane	GO:005765	10.5	HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5
5	transport vesicle membrane	GO:030658	10.5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA, HLA-DQB1
6	endocytic vesicle membrane	GO:030666	10.4	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
7	late endosome membrane	GO:031902	10.4	HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DMB, HLA-DMA
8	Golgi membrane	GO:000139	10.3	GAD2, TLR3, HLA-F, HLA-E, HLA-DRB5, HLA-DRB4
9	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.3	HLA-G, HLA-F, HLA-E, HLA-DRB5, HLA-DRB4, HLA-DRB3
10	ER to Golgi transport vesicle membrane	GO:012507	10.2	HLA-DQA2, HLA-DQA1, HLA-DPB1, HLA-DPA1, HLA-C, HLA-B
11	MHC class I protein complex	GO:042612	10.2	HLA-G, HLA-F, HLA-E, HLA-C, HLA-B, HLA-A
12	phagocytic vesicle membrane	GO:030670	10.1	HLA-G, HLA-F, HLA-E, HLA-C, HLA-B, HLA-A
13	endosome membrane	GO:010008	9.6	TF, TLR3, HLA-DQB1, HLA-DQA2, HLA-DQA1, HLA-DPB1
14	integral to plasma membrane	GO:005887	9.4	TNF, TPO, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA
15	external side of plasma membrane	GO:009897	9.1	CXCL10, IL2RB, IL13, ITGAL, CD40, CD83
16	extracellular space	GO:005615	5.2	ADA, ICAM1, IFNG, IFNB1, IFNA8, IFNA7
17	plasma membrane	GO:005886	INF	HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, TRH
18	extracellular region	GO:005576	INF	TSHB, IFNA8, IFNA7, IFNA6, IFNA5, IFNA4

Biological processes related to autoimmune thyroiditis according to GeneDecks:

(show top 50)    (show all 91)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of type I interferon-mediated signaling pathway	GO:060338	11.0	IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2
2	T-helper 1 type immune response	GO:042088	10.8	IL18, IL12B, HLA-DRB4, HLA-DRB5, HLA-DRB3, HLA-DRB1
3	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	10.7	HLA-DOA, HLA-DPB1, HLA-DQB1, HLA-DOB, HLA-DPA1, HLA-DQA1
4	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	10.7	HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1
5	type I interferon-mediated signaling pathway	GO:060337	10.7	IFNA4, IFNA10, IFNA13, IFNA14, IFNA16, PSMB8
6	T cell receptor signaling pathway	GO:050852	10.7	HLA-DRA, HLA-DQB1, HLA-DQA1, HLA-DPB1, HLA-DQA2, HLA-DRB5
7	humoral immune response mediated by circulating immunoglobulin	GO:002455	10.6	HLA-DRB3, HLA-DQB1, HLA-DRB1, HLA-DRB5, HLA-DRB4
8	T cell costimulation	GO:031295	10.6	CD28, CD86, CD80, ICOS, HLA-DPA1, HLA-DPB1
9	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.6	HLA-E, HLA-G, HLA-F, HLA-C, HLA-B, HLA-A
10	detection of bacterium	GO:016045	10.5	HLA-B, HLA-DRB3, HLA-DRB4, HLA-A, HLA-DRB1, HLA-DRB5
11	cellular response to interferon-gamma	GO:071346	10.5	HLA-DPA1, CCL2, TLR3, IL18, IL12B, CCL5
12	positive regulation of interleukin-12 production	GO:032735	10.4	IL12B, CD40, CD40LG, IL23R, IFNG, HLA-G
13	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	10.4	TAP2, HLA-A, TAP1, HLA-B, HLA-C, HLA-E
14	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	10.4	HLA-G, TAP2, PSMB8, HLA-A, HLA-B, HLA-C
15	negative regulation of interferon-gamma production	GO:032689	10.4	HLA-DRB3, LILRB1, FOXP3, IL10, HLA-DRB1, HLA-DRB4
16	interferon-gamma-mediated signaling pathway	GO:060333	10.3	HLA-DPA1, VCAM1, IFNG, ICAM1, HLA-A, HLA-B
17	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	10.3	HLA-F, PSMB9, TAP1, HLA-G, HLA-E, HLA-A
18	defense response to virus	GO:051607	10.3	CD86, CXCL10, PRF1, TLR3, IFNB1, IL6
19	positive regulation of interleukin-17 production	GO:032740	10.2	IL12B, IL15, IL18, IL2, IL23R, TGFB1
20	chemotaxis	GO:006935	10.2	CXCL9, IL4, CCL2, CCL20, CCL17, CCL5
21	response to virus	GO:009615	10.1	IFNA7, IFNA6, IFNA5, IFNA4, IFNA21, IFNA2
22	response to lipopolysaccharide	GO:032496	10.1	TNFRSF1A, SELE, IL13, IL1A, CXCL10, LTA
23	leukocyte cell-cell adhesion	GO:007159	10.1	VCAM1, SELE, CD40LG, ITGAL, ITGB2, CALCA
24	regulation of immune response	GO:050776	10.1	IL4, ICAM1, HLA-A, HLA-E, HLA-B, HLA-C
25	negative regulation of T cell proliferation	GO:042130	10.1	LILRB1, FOXP3, HLA-DRB5, HLA-DRB4, IL10, HLA-DRB3
26	lymph node development	GO:048535	10.0	TGFB1, CXCL13, IL15, CXCR5, LTA
27	cellular response to lipopolysaccharide	GO:071222	9.9	TNFRSF1B, IFNG, ICAM1, LILRB1, IL10, IL12B
28	negative regulation of growth of symbiont in host	GO:044130	9.8	IL10, IL12B, MBL2, TNF, LTA, IFNG
29	humoral immune response	GO:006959	9.6	IFNG, CD83, TNF, CCL2, IFNB1, AIRE
30	positive regulation of T cell proliferation	GO:042102	9.6	IFNG, CCL5, IL6, IL4, IL23R, IL1B
31	response to estrogen stimulus	GO:043627	9.6	TSHB, FAS, GHRL, CCL5, ESR1, PTPRN
32	positive regulation of B cell proliferation	GO:030890	9.6	ADA, IL4, IL2, IL13, CD40, CD40LG
33	B cell proliferation	GO:042100	9.4	IL10, CD40, CD40LG, BCL2, IFNB1
34	aging	GO:007568	9.4	ADA, IL15, IL1B, FAS, CCL2, CCL5
35	positive regulation of interferon-gamma production	GO:032729	9.3	IL18, CD40LG, IL12B, IL1B, IL2, IL23R
36	positive regulation of chemokine biosynthetic process	GO:045080	9.3	TLR3, TNF, IL1B, IL4, IFNG
37	response to drug	GO:042493	8.9	ICAM1, IL4, IFNG, GPX3, CCL5, CCL2
38	response to glucocorticoid stimulus	GO:051384	8.7	IL1RN, ACADS, FAS, TNF, CCL5, IL10
39	cell-cell signaling	GO:007267	8.6	CXCL13, IL15, IL13, IL10, INS, AR
40	MAPK cascade	GO:000165	8.6	RET, INS, CCL2, TGFB1, TNF, CCL5
41	response to hypoxia	GO:001666	8.4	ADA, TNFRSF1A, SRF, LTA, TGFB1, CXCL12
42	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.1	IL6, IL10, IL4, IL5, ESR1, ESR2
43	anti-apoptosis	GO:006916	8.1	TNFRSF18, TNF, FAS, BCL2, MPO, CD40LG
44	inflammatory response	GO:006954	6.7	SELE, IL5, IL23R, IL1B, IL1A, IL18
45	blood coagulation	GO:007596	INF	IFNA21, TGFB1, PPBP, IFNA16, TP53, TIMP1
46	signal transduction	GO:007165	INF	ESR1, GAST, CCL20, CCL2, FAS, FASLG
47	cytokine-mediated signaling pathway	GO:019221	INF	PTPRN, PSMB8, HLA-G, IL6, IL5, IL2RB
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	IL6, THRB, TLR3, SRF, TNFRSF1A, TP53
49	innate immune response	GO:045087	INF	IFIH1, BCL2, IFNA13, IFNA16, IFNA10, IFNA17
50	immune response	GO:006955	INF	CTLA4, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DRA

Molecular functions related to autoimmune thyroiditis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine receptor binding	GO:005126	10.8	IFNA8, IFNA6, IFNA5, IFNA21, IFNA14, IFNA10
2	MHC class II receptor activity	GO:032395	10.7	HLA-DRB4, HLA-DOA, HLA-DRB3, HLA-DRB1, HLA-DRA, HLA-DQB1
3	interferon-alpha/beta receptor binding	GO:005132	10.6	IFNB1, IFNA7, IFNA4, IFNA2, IFNA17, IFNA16
4	tumor necrosis factor-activated receptor activity	GO:005031	10.5	FAS, TNFRSF18, TNFRSF1A, TNFRSF1B
5	MHC class I receptor activity	GO:032393	10.3	HLA-G, HLA-F, HLA-E, HLA-C, HLA-B, HLA-A
6	peptide antigen binding	GO:042605	10.1	TAP1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1
7	chemokine activity	GO:008009	10.0	CXCL9, CXCL13, CXCL12, CXCL11, CXCL10, PPBP
8	receptor binding	GO:005102	9.4	HLA-B, HLA-G, LTA, PRDX5, CXCL10, CXCL12
9	protease binding	GO:002020	8.3	TNFRSF1A, TNF, TP53, HSPA1B, INS, CD28
10	growth factor activity	GO:008083	8.0	CXCL12, TGFB1, PPBP, IL6, IL5, IL4
11	cytokine activity	GO:005125	7.9	TNF, IFNG, IFNB1, IFNA8, IFNA7, IFNA6
12	protein binding	GO:005515	INF	TNF, TNFRSF1A, TNFRSF1B, , PTPN22, PTPN3