MCID: ATM003
MIFTS: 66

Autoimmune Thyroiditis malady

Endocrine, Immune categories

Summaries for Autoimmune Thyroiditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hashimoto’s syndrome is a form of chronic inflammation of the thyroid gland. the inflammation results in damage to the thyroid gland and reduced thyroid function or “hypothyroidism,” meaning the gland doesn’t make enough thyroid hormone for the needs of the body. symptoms of hashimoto’s syndrome may include goiter, a feeling of fullness in the throat, tiredness, weight gain, cold intolerance, and a slowed heart rate. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it commonly appears between age 40 and age 60. a person with hashimoto’s syndrome may not always need treatment. when it is needed, the condition is treated with synthetic thyroid hormone. last updated: 12/15/2010

MalaCards: Autoimmune Thyroiditis, also known as hashimoto thyroiditis, is related to thyroiditis and autoimmune hepatitis. An important gene associated with Autoimmune Thyroiditis is HT (Hashimoto thyroiditis), and among its related pathways are Allograft rejection and Allograft rejection. The drugs thyroglobulin and thyroid (usp) and the compounds tyrosine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, bone marrow and whole blood, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Genetics Home Reference:21 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Wikipedia:64 Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis, is a disease in which the body interprets the... more...

Aliases & Classifications for Autoimmune Thyroiditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 61UMLS, 9diseasecard, 22GTR, 47OMIM, 45Novoseek, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine, Immune


Aliases & Descriptions:

autoimmune thyroiditis 8 43 21 10 61
hashimoto thyroiditis 8 9 22 21 47
chronic lymphocytic thyroiditis 8 43 21
hashimoto's disease 8 43 21
lymphocytic thyroiditis 8 21
hashimoto's syndrome 8 43
hashimoto disease 21 61
autoimmune chronic lymphocytic thyroiditis 21
chronic lymphocytic thyroiditides 21
hashimoto's thyroiditis 8
hashimotos thyroiditis 45
thyroiditis, chronic 43
thyroiditis chronic 45
hashimoto syndrome 21
hashimoto's struma 43
hashimoto struma 21


External Ids:

Disease Ontology8 DOID:7188
NCIt40 C27191
ICD1025 E06.2, E06.3

Related Diseases for Autoimmune Thyroiditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Autoimmune Thyroiditis family:

acute thyroiditis subacute thyroiditis
thyroiditis

Diseases related to Autoimmune Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 233)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.0FASLG, CTLA4, PTPN22, TSHR, TPO, TG
2autoimmune hepatitis30.9TPO, AIRE, CTLA4
3celiac disease30.9TG, TPO, PTPN22, CTLA4
4hepatitis c30.8TSHR, IL12B, CTLA4
5graves' disease30.8IL12B, LMOD1, FCRL3, SLC26A4, PTPN22, TSHR
6vitiligo30.7CTLA4, AIRE, PTPN22, TPO
7thyroid cancer30.7TSHR, TPO, TG
8arthritis30.5PTPN22, CTLA4
9systemic lupus erythematosus30.3FASLG, CTLA4, CD40, IL12B, FCRL3, PTPN22
10sjogren's syndrome30.3TSHR, CD40, GAD1, FASLG
11multinodular goiter30.1SLC26A4, TSHR, TPO, TG
12myxedema30.1TG, TPO, TSHR
13subacute thyroiditis30.1TSHR, TPO, TG
14thyrotoxicosis30.1TSHR, TPO, TG
15thymoma30.1AIRE, CTLA4
16hepatitis b30.1CTLA4, CD40, IL12B
17alopecia30.1AIRE
18endemic goiter30.1TG, TPO, TSHR
19adenoma29.9CTLA4, LMOD1, SLC26A4, TSHR, TPO, TG
20nodular goiter29.9CTLA4, TSHR, TPO, TG
21papillary carcinoma29.9TG, TPO, TSHR, SLC26A4
22congenital hypothyroidism29.9TG, TPO, TSHR
23pendred syndrome29.9SLC26A4, TPO, TG
24hypoparathyroidism29.9AIRE, CTLA4
25alopecia areata29.9AIRE
26thyroid adenoma29.9TSHR, TPO, TG
27struma ovarii29.9TG, TSHR
28vasculitis29.9CTLA4
29hyperthyroxinemia29.9TPO, TSHR
30infertility29.9TPO
31polymyositis29.9CD40, CTLA4
32hypothyroidism, autoimmune10.7
33hepatitis a10.6
34subacute lymphocytic thyroiditis10.4
35hepatitis d10.4
36granuloma annulare10.4
37acute thyroiditis10.3
38cryoglobulinemia10.3
39n syndrome10.3
40urticaria10.3
41autoimmune thyroid disease 210.3
42thyroid lymphoma10.3
43autoimmune polyglandular syndrome type 310.3
44autoimmune thyroid disease 110.3
45h. pylori infection10.3
46cushing's syndrome10.2
47bipolar disorder10.2
48turner syndrome10.2
49allergic autoimmune thyroiditis10.2
50hashimoto's encephalitis10.2

Graphical network of the top 20 diseases related to Autoimmune Thyroiditis:



Diseases related to autoimmune thyroiditis

Clinical Features for Autoimmune Thyroiditis

Drugs & Therapeutics for Autoimmune Thyroiditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autoimmune Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Thyroiditis

Search NIH Clinical Center for Autoimmune Thyroiditis

Search CenterWatch for Autoimmune Thyroiditis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Autoimmune Thyroiditis

Sources:
22GTR
See all sources

Genetic tests related to Autoimmune Thyroiditis:

id Genetic test Affiliating Genes
1 Hashimoto Thyroiditis22

Anatomical Context for Autoimmune Thyroiditis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Autoimmune Thyroiditis:

33
Bone marrow, Whole blood, Lymph node, Brain, Heart, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Monocytes, T cells, B cells, Endothelial, Fetal brain, Hypothalamus, Fetal thyroid, Pituitary

FMA organs/tissues related to Autoimmune Thyroiditis:

14
Thyroid gl

Animal Models for Autoimmune Thyroiditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Autoimmune Thyroiditis

Sources:
51PubMed
See all sources

Articles related to Autoimmune Thyroiditis:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Ultrasonographic characterization of cervical lymphadenopathy in chronic autoimmune thyroiditis. (23167267)
2013
2
Bartonella henselae infection associated with autoimmune thyroiditis in a child. (23446023)
2013
3
Follicular B Cells in Thyroids of Mice with Spontaneous Autoimmune Thyroiditis Contribute to Disease Pathogenesis and Are Targets of Anti-CD20 Antibody Therapy. (24376265)
2013
4
Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10. (23902475)
2013
5
Neck lymph nodes in chronic autoimmune thyroiditis: the sonographic pattern. (22946552)
2013
6
Does treatment with L-selenomethionine reduce thyroid volume in euthyroid children with autoimmune thyroiditis? (23509205)
2013
7
Antibodies in autoimmune thyroiditis affect glucose metabolism of anterior cingulate. (24365060)
2013
8
Invariant NKT Cell Lines Derived from the NODA^H2 Mouse Enhance Autoimmune Thyroiditis. (21603172)
2011
9
More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels. (21444648)
2011
10
Resolution of Cushing's syndrome and exacerbation of autoimmune thyroiditis. (21275768)
2011
11
Encephalopathy associated with autoimmune thyroid disease (Hashimoto's thyroiditis) presenting as depression: a case report. (21762998)
2011
12
Helicobacter pylori infection might be responsible for the interconnection between type 1 diabetes and autoimmune thyroiditis. (22029731)
2011
13
Relevance of autoimmune thyroiditis in children and adolescents with vitiligo. (21244381)
2011
14
TRAIL and DR5 promote thyroid follicular cell apoptosis in iodine excess-induced experimental autoimmune thyroiditis in NOD mice. (21225479)
2011
15
Interleukin-1I^, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis. (20929277)
2010
16
Analysis of thyroglobulin gene polymorphisms in patients with autoimmune thyroiditis. (20960158)
2010
17
Autoimmune thyroiditis presenting as palmoplantar keratoderma. (20300544)
2010
18
Expression of immunoregulatory molecules by thyrocytes protects nonobese diabetic-H2h4 mice from developing autoimmune thyroiditis. (18988676)
2009
19
CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis. (19441886)
2009
20
Environmental triggers of autoimmune thyroiditis. (19818584)
2009
21
Autoimmune thyroiditis associated with marrow fibrosis and pancytopenia. (19860619)
2009
22
Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. (17919982)
2008
23
Thyroid nodules and cancer in children and adolescents affected by autoimmune thyroiditis. (18524742)
2008
24
Interleukin-10 promotes resolution of granulomatous experimental autoimmune thyroiditis. (18467701)
2008
25
Efficacy of selenium treatment in autoimmune thyroiditis demands an intact selenoprotein transport network. (17274757)
2007
26
Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents. (17140771)
2007
27
Murine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice. (17322373)
2007
28
Is there anything to the reported association between Helicobacter pylori infection and autoimmune thyroiditis? (15745105)
2005
29
Autoimmune thyroiditis with associated proteinuria: report of two patients. (15813612)
2005
30
High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism. (15531503)
2004
31
High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. (15012623)
2004
32
Autoimmune thyroiditis in association with membranous nephropathy. (14960028)
2004
33
HLA-DRB1*04 and HLA-DQB1*03 association with the atrophic but not with the goitrous form of chronic autoimmune thyroiditis in a Brazilian population. (15305234)
2004
34
Complete remission of pure white cell aplasia associated with thymoma, autoimmune thyroiditis and type 1 diabetes. (12605664)
2003
35
Association of lichen sclerosus and autoimmune thyroiditis: possible role of Borrelia burgdorferi? (12593730)
2002
36
Chemokines modulate experimental autoimmune thyroiditis through attraction of autoreactive or regulatory T cells. (12432574)
2002
37
Thyroid resistance to TSH complicated by autoimmune thyroiditis. (11549705)
2001
38
Anti-CD38 autoimmunity in patients with chronic autoimmune thyroiditis or Graves' disease. (11737057)
2001
39
Autoimmune thyroiditis and acquired demyelinating polyradiculoneuropathy. (11532554)
2001
40
Coeliac disease in patients with autoimmune thyroiditis. (11549838)
2001
41
Autoimmune thyroiditis and vitiligo in a child with minimal change nephrotic syndrome. (11793116)
2001
42
Autoimmune thyroiditis in children with Turner syndrome. (11155770)
2000
43
Characterization of thyroid fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis. (11129650)
2000
44
Fine-needle biopsy cytology in autoimmune thyroiditis. (10756865)
1998
45
Expression of tenascin in lymphocytic autoimmune thyroiditis. (9462272)
1997
46
Role of mouse and human class II transgenes in susceptibility to and protection against mouse autoimmune thyroiditis. (9218533)
1997
47
Serum selenium concentrations in patients with autoimmune thyroiditis and non-toxic nodular goiter. (7508739)
1993
48
Thyroid-gland malakoplakia with autoimmune thyroiditis. (8314230)
1993
49
Transient thyrotoxicosis and persistent hypothyroidism due to acute autoimmune thyroiditis after interleukin-2 and interferon-alpha therapy for metastatic carcinoma: a case report. (1558092)
1992
50
Autoimmune thyroiditis and generalized granuloma annulare: remission of the skin lesions after thyroxine therapy. (3678551)
1987

Genetic Variations for Autoimmune Thyroiditis

Expression for genes affiliated with Autoimmune Thyroiditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autoimmune Thyroiditis

Search GEO for disease gene expression data for Autoimmune Thyroiditis.

Pathways for genes affiliated with Autoimmune Thyroiditis

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database
See all sources

Pathways related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8IL12B, CD40, GAD1, CTLA4, FASLG
2
Hide members
10.7TG, TPO, TSHR
3
Hide members
10.6TPO, TG
4
Hide members
10.6TPO, GAD1

Compounds for genes affiliated with Autoimmune Thyroiditis

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.6FASLG, CTLA4, GAD1, AIRE, CD40, LMOD1
2glutamate4511.4FASLG, CTLA4, GAD1, CD40, PTPN22, TSHR
3cysteine4511.4FASLG, CTLA4, GAD1, CD40, LMOD1, TSHR
4iodine45 2412.3TG, TPO, TSHR, SLC26A4, LMOD1, CTLA4
5cholesterol45 29 11 2414.2FASLG, CTLA4, GAD1, CD40, TSHR, TPO
6iodide45 2412.2LMOD1, SLC26A4, TSHR, TPO, TG
7triiodothyronine4511.2LMOD1, SLC26A4, TSHR, TPO, TG
8thyroxine45 2412.2LMOD1, SLC26A4, TSHR, TPO, TG
9nitric oxide45 11 2413.2FASLG, GAD1, CD40, IL12B, SLC26A4, TPO
10h2o24511.2FASLG, GAD1, CD40, SLC26A4, TPO
11sodium iodide4511.2SLC26A4, TSHR, TPO, TG
12cyclosporin a45 29 6013.2FASLG, CTLA4, GAD1, CD40, TG
13125i4511.1LMOD1, TSHR, TPO, TG
14thymidine45 2412.1TG, TSHR, CD40, CTLA4, FASLG
15aspartate4511.1FASLG, GAD1, TSHR, TPO, TG
16prednisolone45 29 1113.1TG, TSHR, CD40, GAD1
17gold4511.1FASLG, GAD1, TPO, TG
18adenylate4511.1TG, TPO, TSHR, CD40, FASLG
19ionomycin4511.1FASLG, CTLA4, CD40, TSHR
20perchlorate4511.1TG, TPO, SLC26A4
21amiodarone45 50 29 1114.1LMOD1, TPO, TG
22methimazole45 2 1113.0TG, TPO, TSHR
23il 104511.0IL12B, CD40, CTLA4
24ribonucleic acid4511.0TG, TPO, TSHR, CD40
25ivig4511.0FASLG, CD40, TG
26iodotyrosine45 2412.0TPO, TG
27rantes4511.0FASLG, CD40, IL12B
28diiodotyrosine4511.0TG, TPO
29rituximab45 50 1113.0CD40, CTLA4, FASLG
30sb 20358045 6012.0FASLG, AIRE, CD40, IL12B
31propylthiouracil45 2 1113.0TG
32methionine4511.0CTLA4, GAD1, SUMO4, TSHR
33polysaccharide4511.0TG, TPO, TSHR, FASLG
34chromium4511.0TPO
35carbimazole45 1111.9TSHR, TPO
36acetylcholine45 50 29 11 2414.9CTLA4, GAD1, TPO, TG
37atpo45 2911.9FASLG, TPO
38dithiothreitol4510.9CD40, LMOD1, TPO
3918f fluorodeoxyglucose4510.9GAD1, TG
40cytosine45 2411.9TSHR, AIRE, GAD1
41cycloheximide4510.9FASLG
42sodium dodecylsulfate4510.8TG, TPO, IL12B
43ly2940024510.8IL12B, CD40, CTLA4, FASLG
44biotin45 11 2412.8FASLG, CD40, TSHR
45wortmannin4510.8FASLG, CTLA4, CD40, IL12B
46oligonucleotide4510.7FASLG, GAD1, CD40, TSHR, TPO
47sodium nitroprusside4510.7FASLG, CD40, IL12B
48amino acid4510.6TPO, TSHR
49hydrocortisone45 2 60 1113.3TG, TPO

GO Terms for genes affiliated with Autoimmune Thyroiditis

Sources:
16Gene Ontology
See all sources

Biological processes related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.6TG, TPO
2positive regulation of endothelial cell apoptotic processGO:200035310.5CD40, FASLG
3hormone biosynthetic processGO:04244610.3TG, TPO

Products for genes affiliated with Autoimmune Thyroiditis

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Sources for Autoimmune Thyroiditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet