MCID: ATM003
MIFTS: 58

Autoimmune Thyroiditis malady

Rare diseases, Endocrine diseases, Immune diseases categories

Summaries for Autoimmune Thyroiditis

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NIH Rare Diseases:41 Hashimoto’s syndrome is a form of chronic inflammation of the thyroid gland. the inflammation results in damage to the thyroid gland and reduced thyroid function or “hypothyroidism,” meaning the gland doesn’t make enough thyroid hormone for the needs of the body. symptoms of hashimoto’s syndrome may include goiter, a feeling of fullness in the throat, tiredness, weight gain, cold intolerance, and a slowed heart rate. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it commonly appears between age 40 and age 60. a person with hashimoto’s syndrome may not always need treatment. when it is needed, the condition is treated with synthetic thyroid hormone. last updated: 12/15/2010

MalaCards based summary: Autoimmune Thyroiditis, also known as chronic lymphocytic thyroiditis, is related to thyroiditis and hypothyroidism. An important gene associated with Autoimmune Thyroiditis is CXCL11 (chemokine (C-X-C motif) ligand 11), and among its related pathways are Immune response Bacterial infections in normal airways and CXCR3-mediated signaling events. The drugs thyroglobulin and thyroid (usp) and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and t cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:9 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Wikipedia:63 Autoimmune thyroiditis, (or Chronic Autoimmune thyroiditis), is a disease in which the body interprets... more...

Aliases & Classifications for Autoimmune Thyroiditis

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Autoimmune Thyroiditis, Aliases & Descriptions:

Name: Autoimmune Thyroiditis 9 41 11 60
Chronic Lymphocytic Thyroiditis 9 41
Hashimoto's Syndrome 9 41
Hashimoto's Disease 9 41
Hashimoto's Thyroiditis 9
Lymphocytic Thyroiditis 9
 
Hashimotos Thyroiditis 43
Hashimoto Thyroiditis 9
Thyroiditis, Chronic 41
Thyroiditis Chronic 43
Hashimoto's Struma 41
Hashimoto Disease 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


External Ids:

Disease Ontology9 DOID:7188
NCIt38 C27191
ICD1025 E06.2, E06.3

Related Diseases for Autoimmune Thyroiditis

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Diseases in the Thyroiditis family:

autoimmune thyroiditis Subacute Thyroiditis
Acute Thyroiditis

Diseases related to Autoimmune Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.6TPO, TG
2hypothyroidism31.5TG, TPO
3celiac disease31.3TG, TPO
4hyperthyroidism31.0TPO, TG
5goiter30.9TG, TPO
6hepatitis c30.9CXCL10, CXCL11
7autoimmune hepatitis30.6AIRE, TPO
8myxedema30.6TG, TPO
9thyrotoxicosis30.6TPO, TG
10nodular goiter30.6TG, TPO
11turner syndrome30.6TG, TPO
12endemic goiter30.6TG, TPO
13thyroid cancer30.6TPO, TG
14graves' disease30.5TPO, AIRE, TG, CXCL10
15allergic contact dermatitis30.5CXCL11, CXCL10
16subacute thyroiditis30.4TG, TPO
17dermatitis30.4CXCL10, CXCL11, CCL17
18pendred syndrome30.4TG, TPO
19congenital hypothyroidism30.3TG, TPO
20hashimoto thyroiditis30.2TG, TPO, AIRE
21papillary carcinoma30.2TG, TPO
22atherosclerosis30.0TPO, CXCL11, CXCL10
23hepatitis10.7
24obesity10.5
25subacute lymphocytic thyroiditis10.5
26arthritis10.4
27granuloma annulare10.4
28cryoglobulinemia10.4
29rheumatoid arthritis10.3
30gastritis10.3
31lupus erythematosus10.3
32urticaria10.3
33systemic lupus erythematosus10.3
34autoimmune thyroid disease 310.3
35glomerulonephritis10.3
36sjogren's syndrome10.3
37nephrotic syndrome10.3
38psoriasis10.3
39allergic autoimmune thyroiditis10.3
40autoimmune polyglandular syndrome type 310.3
41goiter, multinodular 1, with or without sertoli-leydig cell tumors10.3TG, TPO
42pernicious anemia10.3TPO, TG
43toxic diffuse goiter10.3TG, TPO
44nontoxic goiter10.3TPO, TG
45plummer's disease10.3TG, TPO
46multinodular goiter10.3TPO, TG
47hypothryoidism, congenital, nongoitrous 410.3TG, TPO
48uveitis10.2CXCL10, CXCL11
49thyroid carcinoma, follicular10.2TPO, TG
50breast cancer10.2

Graphical network of the top 20 diseases related to Autoimmune Thyroiditis:



Diseases related to autoimmune thyroiditis

Symptoms for Autoimmune Thyroiditis

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Drugs & Therapeutics for Autoimmune Thyroiditis

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Drug clinical trials:

Search ClinicalTrials for Autoimmune Thyroiditis

Search NIH Clinical Center for Autoimmune Thyroiditis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Autoimmune Thyroiditis

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Anatomical Context for Autoimmune Thyroiditis

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MalaCards organs/tissues related to Autoimmune Thyroiditis:

31
Thyroid, T cells, Heart, B cells, Eye, Bone, Lymph node, Brain, Breast, Ovary, Testes, Monocytes, Bone marrow, Whole blood, Salivary gland, Skin, Endothelial, Pituitary, Neutrophil

FMA organs/tissues related to Autoimmune Thyroiditis:

14
Thyroid gl

Animal Models for Autoimmune Thyroiditis or affiliated genes

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MGI Mouse Phenotypes related to Autoimmune Thyroiditis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0CCL17, CXCL10, TG, TPO, AIRE
2MP:00053767.8ACADS, CXCL10, TG, TPO, AIRE
3MP:00053847.3AIRE, CXCL10, FOXD3, CCL17, ACADS

Publications for Autoimmune Thyroiditis

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Articles related to Autoimmune Thyroiditis:

(show top 50)    (show all 893)
idTitleAuthorsYear
1
BalA^-like lesion associated with psoriasis and chronic autoimmune thyroiditis. (25847070)
2015
2
Interleukin-10 influences susceptibility to experimental autoimmune thyroiditis independently of the H-2 gene. (25482126)
2015
3
Effects of latent toxoplasmosis on autoimmune thyroid diseases in pregnancy. (25350671)
2014
4
Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis. (25150037)
2014
5
Immunological Characteristics of Children with Hashimoto's Autoimmune Thyroiditis. (25248347)
2014
6
Autoimmune thyroid disease in vitiligo: multivariate analysis indicates intricate pathomechanisms. (23253044)
2013
7
A possible association of hypokalaemic periodic paralysis, autoimmune thyroiditis and neuromyotonia. (24385062)
2013
8
Screening of SLC26A4 gene in autoimmune thyroid diseases. (23280318)
2013
9
The misdiagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis as masked depression in an elderly euthyroid woman. (23453127)
2013
10
Ultrasonographic characterization of cervical lymphadenopathy in chronic autoimmune thyroiditis. (23167267)
2013
11
Xiaoyin recipe ( ) for psoriasis induces a Th1/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats. (22311410)
2012
12
Invariant NKT Cell Lines Derived from the NODA^H2 Mouse Enhance Autoimmune Thyroiditis. (21603172)
2011
13
The clinical presentation of autoimmune thyroid disease in men is associated with IL12B genotype. (21198744)
2011
14
SLC26A4 expression among autoimmune thyroid tissues. (21035230)
2011
15
Chronic pulmonary bleeding as the first sign of microscopic polyangiitis associated with autoimmune thyroiditis. (21738252)
2011
16
The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. (20356797)
2010
17
Antithyroid antibodies of varying specificity in the pathogenesis and diagnosis of autoimmune thyroid diseases]. (19947439)
2009
18
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. (20134044)
2009
19
Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. (17919982)
2008
20
Altered expression of T lymphocyte surface markers in children with chronic autoimmune thyroiditis. (19218661)
2008
21
Lack of association between interleukin-4 gene polymorphisms and autoimmune thyroid diseases amongst Taiwanese Chinese. (18058260)
2007
22
Association analysis of interleukin gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (17964974)
2007
23
Antigenic determinants to GAD autoantibodies in patients with type 1 diabetes with and without autoimmune thyroid disease. (17130557)
2006
24
Soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases: relation to humoral immune response markers. (17357290)
2006
25
Incidence of iodine deficiency in patients presenting with goitre--discrepancy between clinical and ultrasonographic evaluation of the thyroid: comparison of patients with and without autoimmune thyroiditis--clinical, hormonal and urinary iodine excretion studies. (16509527)
2006
26
18q deletion syndrome associated with autoimmune thyroid disease presenting as hyperthyroidism. (15844478)
2005
27
Diagnosis of autoimmune thyroid disease]. (16405253)
2005
28
Prevalence of the triple X syndrome in phenotypically normal women with premature ovarian failure and its association with autoimmune thyroid disorders. (14556833)
2003
29
Consequences of autoimmune thyroiditis before, during and after pregnancy. (14605606)
2003
30
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis. (14746804)
2003
31
Severe aplastic anemia with autoimmune thyroiditis showing no hematological response to intensive immunosuppressive therapy. (12624493)
2003
32
Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease. (14679088)
2003
33
Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto's encephalitis? (14616889)
2003
34
Genetic dissection of familial autoimmune thyroid diseases using whole genome screening. (12848996)
2002
35
Rarity of encephalopathy associated with autoimmune thyroiditis: a case series from Mayo Clinic from 1950 to 1996. (12097200)
2002
36
Absence of cross-reactivity to myeloperoxidase of anti-thyroid microsomal antibodies in patients with autoimmune thyroid diseases. (11217812)
2001
37
Usefulness of screening program for celiac disease in autoimmune thyroiditis. (10711459)
2000
38
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. (11129116)
2000
39
Fine-needle biopsy cytology in autoimmune thyroiditis. (10756865)
1998
40
Somatic hypermutation in autoimmune thyroid disease. (9602367)
1998
41
The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis. (9878080)
1998
42
Autoimmune thyroid disease in patients with type 1 diabetes mellitus]. (9588075)
1998
43
Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population. (9285944)
1997
44
Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice. (8938107)
1996
45
Isolation of thyroid peroxidase and lack of autoantibodies to the enzyme in dogs with autoimmune thyroid disease. (7695146)
1995
46
Echographic diagnosis of pretibial myxedema in patients with autoimmune thyroid disease. (8075779)
1994
47
Deregulated production of interleukin-8 (IL-8) in autoimmune thyroid disease studied by newly developed IL-8 radioimmunoassay. (8003701)
1993
48
The relationship between autoimmune thyroid disease and iodine intake: a review. (1345585)
1992
49
Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. (1829139)
1991
50
Thyroid peroxidase/microsomal antibodies are not identical with thyroid cytotoxic antibodies in autoimmune thyroiditis. (2239089)
1990

Variations for Autoimmune Thyroiditis

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Expression for genes affiliated with Autoimmune Thyroiditis

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Search GEO for disease gene expression data for Autoimmune Thyroiditis.

Pathways for genes affiliated with Autoimmune Thyroiditis

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Pathways related to Autoimmune Thyroiditis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.8CXCL11, CXCL10
29.8CXCL10, CXCL11
3
Show member pathways
9.6TG, TPO
49.6TPO, TG
5
Show member pathways
9.2CXCL11, CXCL10, CCL17
6
Show member pathways
9.2CXCL11, CXCL10, CCL17
7
Show member pathways
9.2CXCL11, CXCL10, CCL17
8
Show member pathways
9.2CCL17, CXCL11, CXCL10
9
Show member pathways
9.2CCL17, CXCL11, CXCL10
10
Show member pathways
9.2CXCL10, CXCL11, CCL17
11
Show member pathways
8.8TPO, CXCL10, CXCL11, CCL17

Compounds for genes affiliated with Autoimmune Thyroiditis

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Compounds related to Autoimmune Thyroiditis according to GeneCards Suite gene sharing:

(show all 31)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2411.0TG, TPO
2diiodotyrosine4310.0TG, TPO
3perchlorate4310.0TPO, TG
4sodium iodide4310.0TG, TPO
5propylthiouracil43 2 1212.0TG, TPO
6gliadin4310.0TG, TPO
7chromium439.9TPO, TG
8iodine43 2410.9TG, TPO
9amiodarone43 49 28 1212.9TG, TPO
10125i439.9TPO, TG
11iodide43 2410.9TG, TPO
12cardiolipin43 1210.9TG, TPO
13methimazole43 2 1211.9TG, TPO
14il 10439.8CCL17, CXCL10
15selenium43 2410.8TG, TPO
16allergens439.7CCL17, CXCL10
17tarc439.6CCL17, CXCL11, CXCL10
18ccl343 2810.6CXCL10, CXCL11, CCL17
19ccl443 2810.6CCL17, CXCL11, CXCL10
20triiodothyronine439.6TPO, TG
21sodium dodecylsulfate439.6TG, TPO
22hydrocortisone43 2 59 1212.6CXCL10, TG, TPO
23gold439.6TPO, TG, CXCL10
24rantes439.6CCL17, CXCL11, CXCL10
25suramin43 28 1211.5CXCL10, TG
26genistein43 28 59 2 24 1214.5TPO, TG, CXCL10
27creatinine439.4TPO, TG, CXCL10
28cyclosporin a43 28 5911.4CCL17, CXCL11, TG
29adenylate439.3TPO, TG, CXCL10
30cycloheximide439.3CXCL10, TG, TPO
31tyrosine438.3CXCL10, TG, TPO, AIRE

GO Terms for genes affiliated with Autoimmune Thyroiditis

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Cellular components related to Autoimmune Thyroiditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.8CCL17, CXCL11, CXCL10, TG
2extracellular spaceGO:00056158.1CCL17, CXCL11, CXCL10, TG, TPO

Biological processes related to Autoimmune Thyroiditis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cAMP metabolic processGO:003081610.0CXCL11, CXCL10
2T cell chemotaxisGO:001081810.0CXCL11, CXCL10
3positive regulation of cAMP-mediated signalingGO:00439509.9CXCL10, CXCL11
4positive regulation of release of sequestered calcium ion into cytosolGO:00512819.8CXCL10, CXCL11
5hormone biosynthetic processGO:00424469.8TPO, TG
6regulation of cell proliferationGO:00421279.8CXCL10, CXCL11
7thyroid hormone generationGO:00065909.7TPO, TG
8chemokine-mediated signaling pathwayGO:00700989.7CXCL10, CXCL11
9chemotaxisGO:00069359.4CCL17, CXCL11, CXCL10
10cell-cell signalingGO:00072679.2CXCL10, CXCL11, CCL17
11inflammatory responseGO:00069548.9CCL17, CXCL11, CXCL10
12immune responseGO:00069558.9CXCL11, AIRE, CXCL10, CCL17

Molecular functions related to Autoimmune Thyroiditis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CXCR3 chemokine receptor bindingGO:00482489.8CXCL11, CXCL10
2chemokine activityGO:00080098.9CCL17, CXCL11, CXCL10

Products for genes affiliated with Autoimmune Thyroiditis

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Sources for Autoimmune Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet