MCID: ATM003
MIFTS: 70

Autoimmune Thyroiditis malady

Endocrine diseases, Immune diseases categories

Summaries for Autoimmune Thyroiditis

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Hashimoto’s syndrome is a form of chronic inflammation of the thyroid gland. the inflammation results in damage to the thyroid gland and reduced thyroid function or “hypothyroidism,” meaning the gland doesn’t make enough thyroid hormone for the needs of the body. symptoms of hashimoto’s syndrome may include goiter, a feeling of fullness in the throat, tiredness, weight gain, cold intolerance, and a slowed heart rate. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it commonly appears between age 40 and age 60. a person with hashimoto’s syndrome may not always need treatment. when it is needed, the condition is treated with synthetic thyroid hormone. last updated: 12/15/2010

MalaCards: Autoimmune Thyroiditis, also known as hashimoto thyroiditis, is related to thyroiditis and hypothyroidism. An important gene associated with Autoimmune Thyroiditis is HT (Hashimoto thyroiditis), and among its related pathways are Allograft rejection and Allograft rejection. The drugs thyroglobulin and thyroid (usp) and the compounds tyrosine and glutamate have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and t cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Disease Ontology:8 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Genetics Home Reference:21 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Wikipedia:63 Autoimmune thyroiditis, or Chronic Autoimmune thyroiditis, is a disease in which the body interprets the... more...

Aliases & Classifications for Autoimmune Thyroiditis

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 60UMLS, 9diseasecard, 22GTR, 46OMIM, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Immune diseases


Aliases & Descriptions:

autoimmune thyroiditis 8 42 21 10 60
hashimoto thyroiditis 8 9 22 21 46
chronic lymphocytic thyroiditis 8 42 21
hashimoto's disease 8 42 21
lymphocytic thyroiditis 8 21
hashimoto's syndrome 8 42
hashimoto disease 21 60
autoimmune chronic lymphocytic thyroiditis 21
chronic lymphocytic thyroiditides 21
hashimoto's thyroiditis 8
hashimotos thyroiditis 44
thyroiditis, chronic 42
thyroiditis chronic 44
hashimoto syndrome 21
hashimoto's struma 42
hashimoto struma 21


External Ids:

Disease Ontology8 DOID:7188
NCIt39 C27191
ICD1025 E06.2, E06.3

Related Diseases for Autoimmune Thyroiditis

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17GeneCards, 18GeneDecks
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Diseases in the Autoimmune Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis
Thyroiditis

Diseases related to Autoimmune Thyroiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis32.1FASLG, CTLA4, PTPN22, TSHR, TPO, TG
2hypothyroidism31.0SLC26A4, TSHR, TPO, TG
3diabetes mellitus30.9CTLA4, GAD1, AIRE, SUMO4, PTPN22
4hepatitis30.9AIRE, CTLA4, FASLG
5autoimmune hepatitis30.9TPO, AIRE, CTLA4
6celiac disease30.9TG, TPO, PTPN22, CTLA4
7hepatitis c30.8TSHR, IL12B, CTLA4
8graves' disease30.7IL12B, LMOD1, FCRL3, SLC26A4, PTPN22, TSHR
9vitiligo30.7CTLA4, AIRE, PTPN22, TPO
10thyroid cancer30.7SLC26A4, TSHR, TPO, TG
11hyperthyroidism30.5CTLA4, CD40, LMOD1, PTPN22, TSHR, TPO
12goiter30.5LMOD1, SLC26A4, TSHR, TPO, TG
13arthritis30.5PTPN22, CTLA4
14rheumatoid arthritis30.3FASLG, CTLA4, CD40, IL12B, FCRL3, SUMO4
15systemic lupus erythematosus30.2FASLG, CTLA4, CD40, IL12B, FCRL3, PTPN22
16multiple sclerosis30.2FASLG, CTLA4, GAD1, CD40, IL12B, PTPN22
17sjogren's syndrome30.2TSHR, CD40, GAD1, FASLG
18psoriasis30.2PTPN22, IL12B, CD40, CTLA4
19sarcoidosis30.2IL12B
20myxedema30.1TG, TPO, TSHR
21subacute thyroiditis30.1TSHR, TPO, TG
22thyrotoxicosis30.1TSHR, TPO, TG
23myasthenia gravis30.1CTLA4, AIRE
24thymoma30.1AIRE, CTLA4
25hepatitis b30.1CTLA4, CD40, IL12B
26connective tissue disease30.1PTPN22, CD40, CTLA4
27alopecia30.1AIRE
28severe combined immunodeficiency30.1CD40
29dermatitis30.1CTLA4
30endemic goiter30.1TG, TPO, TSHR
31follicular thyroid carcinoma30.1TSHR, TG
32adenoma29.9CTLA4, LMOD1, SLC26A4, TSHR, TPO, TG
33nodular goiter29.9CTLA4, TSHR, TPO, TG
34papillary carcinoma29.9TG, TPO, TSHR, SLC26A4
35congenital hypothyroidism29.9TG, TPO, TSHR
36pendred syndrome29.9SLC26A4, TPO, TG
37inflammatory bowel disease29.9CTLA4, CD40, IL12B, PTPN22
38hypoparathyroidism29.9AIRE, CTLA4
39alopecia areata29.9AIRE
40candidiasis29.9AIRE
41papillary thyroid carcinoma29.9TSHR, TPO, TG
42struma ovarii29.9TG, TSHR
43lymphopenia29.9PTPN22, FASLG
44vasculitis29.9CTLA4
45hyperthyroxinemia29.9TPO, TSHR
46infertility29.9TPO
47encephalitis29.9IL12B
48type 1 diabetes mellitus10.5
49obesity10.4
50granuloma annulare10.4

Graphical network of the top 20 diseases related to Autoimmune Thyroiditis:



Diseases related to autoimmune thyroiditis

Clinical Features for Autoimmune Thyroiditis

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Drugs & Therapeutics for Autoimmune Thyroiditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autoimmune Thyroiditis

Drug clinical trials:

Search ClinicalTrials for Autoimmune Thyroiditis

Search NIH Clinical Center for Autoimmune Thyroiditis

Search CenterWatch for Autoimmune Thyroiditis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Autoimmune Thyroiditis

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Sources:
22GTR
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Genetic tests related to Autoimmune Thyroiditis:

id Genetic test Affiliating Genes
1 Hashimoto Thyroiditis22

Anatomical Context for Autoimmune Thyroiditis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Autoimmune Thyroiditis:

32
Thyroid, T cells, Heart, B cells, Eye, Breast, Monocytes, Testes, Pituitary, Lymph node, Bone, Brain, Skin, Bone marrow, Hypothalamus, Endothelial, Ovary, Salivary gland, Liver, Whole blood

FMA organs/tissues related to Autoimmune Thyroiditis:

14
Thyroid gl

Animal Models for Autoimmune Thyroiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autoimmune Thyroiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.2TG, FASLG, CTLA4, AIRE, CD40, IL12B
2MP:000537611.1FASLG, CTLA4, GAD1, AIRE, CD40, IL12B
3MP:000538710.9FASLG, CTLA4, AIRE, CD40, IL12B, ZFAT
4MP:000538810.8CTLA4, GAD1, AIRE, IL12B, PTPN22, FASLG
5MP:000537910.8FASLG, SLC26A4, TSHR, TG
6MP:000538410.7FASLG, CTLA4, GAD1, AIRE, CD40, IL12B

Publications for Autoimmune Thyroiditis

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Sources:
50PubMed
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Articles related to Autoimmune Thyroiditis:

(show top 50)    (show all 1079)
idTitleAuthorsYear
1
Thyroid autoimmunity and BehAset's disease: is there a significant association? (23476155)
2013
2
CTLA-4 gene polymorphisms and their influence on predisposition to autoimmune thyroid diseases (Graves' disease and Hashimoto's thyroiditis). (22851994)
2012
3
Sunitinib-induced autoimmune thyroiditis in a patient with metastatic renal cell carcinoma: a case report. (22584361)
2012
4
Acute hepatitis E virus infection and autoimmune thyroiditis: yet another trigger? (22604767)
2012
5
Analysis of expression and function of the inhibitory receptor ILT2 in lymphocytes from patients with autoimmune thyroid disease. (21551166)
2011
6
The influence of interferon alpha on the induction of autoimmune thyroiditis in patients treated for chronic viral hepatitis type C. (22144218)
2011
7
Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid diseases. (21169670)
2010
8
Autoimmune Thyroiditis, Pernicious Anaemia, Vitiligo and Scleroatrophic Lichen in a boy with short-chain acylCoA dehydrogenase deficiency. (20389114)
2010
9
Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes. (20426819)
2010
10
Diffusion and ADC-map images detect ongoing demyelination on subcortical white matter in an adult metachromatic leukodystrophy patient with autoimmune Hashimoto thyroiditis. (22798296)
2010
11
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? (20464711)
2010
12
Absence of anti-pendrin auto-antibodies in the sera of Tunisian patients with autoimmune thyroid diseases. (20857898)
2010
13
Treatment with thyroxine reduces thyroid volume in euthyroid children and adolescents with chronic autoimmune thyroiditis. (20190541)
2010
14
Structural polymorphism of the mannose-binding lectin 2 (MBL2 ) gene in HCV-infected patients with a serological marker for thyroid autoimmunity. (19703233)
2009
15
Goitrous autoimmune thyroiditis in a pediatric population: a longitudinal study. (18678601)
2008
16
E449X mutation in the thyroid hormone receptor beta associated with autoimmune thyroid disease and severe neuropsychomotor involvement. (19169471)
2008
17
Screening frequency for celiac disease and autoimmune thyroiditis in children and adolescents with type 1 diabetes mellitus--data from a German/Austrian multicentre survey. (18713134)
2008
18
Association analysis of interleukin gene polymorphisms in autoimmune thyroid diseases in the Tunisian population. (17964974)
2007
19
Thyroid autoimmunity in the current iodine environment. (17725430)
2007
20
Soluble CTLA-4 in autoimmune thyroid diseases: relationship with clinical status and possible role in the immune response dysregulation. (17321799)
2007
21
Serum CD40/CD40L system in Graves' disease and Hashimoto's thyroiditis related to soluble Fas, FasL and humoral markers of autoimmune response. (17558708)
2007
22
Murine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice. (17322373)
2007
23
Frequency of diabetes and thyroid autoantibodies in patients with autoimmune endocrine disease from Cameroon. (16298164)
2006
24
Celiac disease occurring in a patient with hypoparathyroidism and autoimmune thyroid disease. (16553106)
2006
25
A single chondroitin 6-sulfate oligosaccharide unit at Ser-2730 of human thyroglobulin enhances hormone formation and limits proteolytic accessibility at the carboxyl terminus. Potential insights into thyroid homeostasis and autoimmunity. (16679516)
2006
26
Autoimmune thyroiditis and Helicobacter pylori--is there a connection? (16804516)
2006
27
Peripheral cytokine expression in autoimmune thyroiditis: effects of in vitro modulation by rosiglitazone and dexamethasone. (17042679)
2006
28
High incidence of spontaneous autoimmune thyroiditis in immunocompetent self-reactive human T cell receptor transgenic mice. (15829400)
2005
29
Association of antipituitary antibody and type 2 iodothyronine deiodinase antibody in patients with autoimmune thyroid disease. (16410660)
2005
30
Association of a CTLA-4 3' untranslated region (CT60) single nucleotide polymorphism with autoimmune thyroid disease in the Japanese population. (16040335)
2005
31
Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis. (15745922)
2005
32
Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease. (16052563)
2005
33
Experimental autoimmune thyroiditis (EAT) induced by the thyroglobulin peptide (2596-2608): influence of H-2 and non H-2 genes. (15621581)
2004
34
Affective disorders associated with autoimmune thyroiditis. (11748327)
2001
35
Autoimmune thyroiditis and vitiligo in a child with minimal change nephrotic syndrome. (11793116)
2001
36
Development of an animal model of autoimmune thyroid eye disease. (10202044)
1999
37
Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand. (9886438)
1999
38
Eosinophilic fasciitis associated with autoimmune thyroid disease and myelodysplasia treated with pulsed methylprednisolone and antihistamines. (10354391)
1999
39
Induction of granulomatous experimental autoimmune thyroiditis in IL-4 gene-disrupted mice. (9551967)
1998
40
Expression of tenascin in lymphocytic autoimmune thyroiditis. (9462272)
1997
41
Simultaneously found transient hypothyroidism due to Hashimoto's thyroiditis, autoimmune hepatitis and isolated ACTH deficiency after cessation of glucocorticoid administration. (9279524)
1997
42
High prevalence of subclinical SjAPgren's syndrome features in patients with autoimmune thyroid disease. (9292794)
1997
43
IgG, IgA and C3 deposits in the extra-thyroidal manifestations of autoimmune Graves' disease: their in vitro solubilization by intravenous immunoglobulin. (8828945)
1996
44
Tracheal stenosis and autoimmune thyroiditis]. (8079247)
1994
45
High prevalence of thyroid autoimmunity in idiopathic Addison's disease. (7858106)
1994
46
Development of thyroid autoimmunity after administration of recombinant human interferon-alpha 2b for chronic viral hepatitis. (8424429)
1993
47
Autoantibodies in the sera of patients with autoimmune thyroid disease recognize a secreted form of human thyroid peroxidase generated in a baculovirus system. (8375572)
1993
48
Mixed connective tissue disease associated with autoimmune hepatitis and thyroiditis. (1586260)
1992
49
T cell responses to synthetic thyroid peroxidase peptides in autoimmune thyroid disease. (1717189)
1991
50
Autoimmunity and the pathogenesis of localized thyroid autonomy (Plummer's disease). (2869844)
1985

Genetic Variations for Autoimmune Thyroiditis

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Expression for genes affiliated with Autoimmune Thyroiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autoimmune Thyroiditis

Search GEO for disease gene expression data for Autoimmune Thyroiditis.

Pathways for genes affiliated with Autoimmune Thyroiditis

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29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database
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Pathways related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.8IL12B, CD40, GAD1, CTLA4, FASLG
2
Hide members
10.7TG, TPO, TSHR
3
Hide members
10.6TPO, TG
4
Hide members
10.6TPO, GAD1

Compounds for genes affiliated with Autoimmune Thyroiditis

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.6FASLG, CTLA4, GAD1, AIRE, CD40, LMOD1
2glutamate4411.4FASLG, CTLA4, GAD1, CD40, PTPN22, TSHR
3cysteine4411.4FASLG, CTLA4, GAD1, CD40, LMOD1, TSHR
4iodine44 2412.3TG, TPO, TSHR, SLC26A4, LMOD1, CTLA4
5cholesterol44 28 11 2414.2FASLG, CTLA4, GAD1, CD40, TSHR, TPO
6iodide44 2412.2LMOD1, SLC26A4, TSHR, TPO, TG
7triiodothyronine4411.2LMOD1, SLC26A4, TSHR, TPO, TG
8thyroxine44 2412.2LMOD1, SLC26A4, TSHR, TPO, TG
9nitric oxide44 11 2413.2FASLG, GAD1, CD40, IL12B, SLC26A4, TPO
10h2o24411.2FASLG, GAD1, CD40, SLC26A4, TPO
11sodium iodide4411.2SLC26A4, TSHR, TPO, TG
12cyclosporin a44 28 5913.2FASLG, CTLA4, GAD1, CD40, TG
13125i4411.1LMOD1, TSHR, TPO, TG
14thymidine44 2412.1TG, TSHR, CD40, CTLA4, FASLG
15aspartate4411.1FASLG, GAD1, TSHR, TPO, TG
16prednisolone44 28 1113.1TG, TSHR, CD40, GAD1
17gold4411.1FASLG, GAD1, TPO, TG
18adenylate4411.1TG, TPO, TSHR, CD40, FASLG
19ionomycin4411.1FASLG, CTLA4, CD40, TSHR
20perchlorate4411.1TG, TPO, SLC26A4
21amiodarone44 49 28 1114.1LMOD1, TPO, TG
22methimazole44 2 1113.0TG, TPO, TSHR
23il 104411.0IL12B, CD40, CTLA4
24ribonucleic acid4411.0TG, TPO, TSHR, CD40
25ivig4411.0FASLG, CD40, TG
26iodotyrosine44 2412.0TPO, TG
27rantes4411.0FASLG, CD40, IL12B
28diiodotyrosine4411.0TG, TPO
29rituximab44 49 1113.0CD40, CTLA4, FASLG
30sb 20358044 5912.0FASLG, AIRE, CD40, IL12B
31propylthiouracil44 2 1113.0TG
32methionine4411.0CTLA4, GAD1, SUMO4, TSHR
33polysaccharide4411.0TG, TPO, TSHR, FASLG
34chromium4411.0TPO
35carbimazole44 1111.9TSHR, TPO
36acetylcholine44 49 28 11 2414.9CTLA4, GAD1, TPO, TG
37atpo44 2811.9FASLG, TPO
38dithiothreitol4410.9CD40, LMOD1, TPO
3918f fluorodeoxyglucose4410.9GAD1, TG
40cytosine44 2411.9TSHR, AIRE, GAD1
41cycloheximide4410.9FASLG
42sodium dodecylsulfate4410.8TG, TPO, IL12B
43ly2940024410.8IL12B, CD40, CTLA4, FASLG
44biotin44 11 2412.8FASLG, CD40, TSHR
45wortmannin4410.8FASLG, CTLA4, CD40, IL12B
46oligonucleotide4410.7FASLG, GAD1, CD40, TSHR, TPO
47sodium nitroprusside4410.7FASLG, CD40, IL12B
48amino acid4410.6TPO, TSHR
49hydrocortisone44 2 59 1113.3TG, TPO

GO Terms for genes affiliated with Autoimmune Thyroiditis

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Sources:
16Gene Ontology
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Biological processes related to Autoimmune Thyroiditis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1thyroid hormone generationGO:00659010.6TG, TPO
2positive regulation of endothelial cell apoptotic processGO:200035310.5CD40, FASLG
3hormone biosynthetic processGO:04244610.3TG, TPO

Products for genes affiliated with Autoimmune Thyroiditis

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Sources for Autoimmune Thyroiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet