MCID: ATN005
MIFTS: 47

Autonomic Dysfunction malady

Neuronal diseases category
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Summaries for Autonomic Dysfunction

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NINDS:43 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function. Most physicians view dysautonomia in terms of failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive ANS activities also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards based summary: Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to hirschsprung's disease and breast cancer. An important gene associated with Autonomic Dysfunction is ECE1 (endothelin converting enzyme 1), and among its related pathways are Sphingolipid metabolism and SIDS Susceptibility Pathways. The compounds catecholamine and cerebroside have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain, and related mouse phenotypes are behavior/neurological and cardiovascular system.

Wikipedia:65 Dysautonomia (or autonomic dysfunction, autonomic neuropathy) is a condition in which the autonomic... more...

Aliases & Classifications for Autonomic Dysfunction

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Sources:
43NINDS, 62UMLS, 44Novoseek
See all sources

Autonomic Dysfunction, Aliases & Descriptions:

Name: Autonomic Dysfunction 43 62
Autonomic Nervous System Disorders 62
 
Autonomic Disorder 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Related Diseases for Autonomic Dysfunction

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Graphical network of the top 20 diseases related to Autonomic Dysfunction:



Diseases related to autonomic dysfunction

Symptoms for Autonomic Dysfunction

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Drugs & Therapeutics for Autonomic Dysfunction

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Drug clinical trials:

Search ClinicalTrials for Autonomic Dysfunction

Search NIH Clinical Center for Autonomic Dysfunction

Genetic Tests for Autonomic Dysfunction

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Anatomical Context for Autonomic Dysfunction

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MalaCards organs/tissues related to Autonomic Dysfunction:

32
Heart, Spinal cord, Brain, Liver, Testes, Skin, Kidney, Ovary, Temporal lobe, Eye, Cortex, Colon, Salivary gland, Breast, Prostate, Hypothalamus

Animal Models for Autonomic Dysfunction or affiliated genes

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MGI Mouse Phenotypes related to Autonomic Dysfunction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053868.4PHOX2B, GLA, MECP2, HCRT
2MP:00053858.2PHOX2B, ECE1, HCRT, GLA
3MP:00053767.7SHMT1, ECE1, HCRT, PHOX2B, MECP2

Publications for Autonomic Dysfunction

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Articles related to Autonomic Dysfunction:

(show top 50)    (show all 558)
idTitleAuthorsYear
1
Autonomic dysfunction in patients with systemic sclerosis: Correlation with intrarenal arterial stiffness. (25200847)
2014
2
Cardiac Autonomic Dysfunction in Patients with Head-up Tilt Test-Induced Vasovagal Syncope. (25139789)
2014
3
Autonomic Dysfunction: A Driving Force for Myocardial Fibrosis in Young Duchenne Muscular Dystrophy Patients? (25399404)
2014
4
Paroxysmal autonomic dysfunction in a patient with chronic rhinosinusitis. (24132043)
2014
5
Autonomic dysfunction according to disease progression in Parkinson's disease. (24382402)
2013
6
Fluctuating cognitive deficits and autonomic dysfunction: clarifying the diagnosis. (23686051)
2013
7
Autonomic dysfunction in Parkinson disease. (24095131)
2013
8
Assessment of autonomic dysfunction in patients with type 2 diabetes using reactive hyperemia. (23583956)
2013
9
Autonomic dysfunction in parkinsonian LRRK2 mutation carriers. (23764467)
2013
10
Emerging drugs for autonomic dysfunction in Parkinson's disease. (23373820)
2013
11
Insights into the clinical and functional significance of cardiac autonomic dysfunction in Chagas disease. (22535000)
2012
12
Differential modulation by vascular nitric oxide synthases of the ethanol-evoked hypotension and autonomic dysfunction in female rats. (23046587)
2012
13
Heart rate variability in assessment of autonomic dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome. (21996103)
2011
14
Cardiovascular autonomic dysfunction in MSA and Parkinson's disease: similarities and differences. (21849175)
2011
15
Cardiac autonomic dysfunction in hemodialysis patients: The value of heart rate turbulence. (21395968)
2011
16
Autonomic dysfunction presenting as postural orthostatic tachycardia syndrome in patients with multiple sclerosis. (20309394)
2010
17
The influence of pediatric autonomic dysfunction on recovery after concussion. (21079448)
2010
18
Insulin resistance as link between polycystic ovary syndrome and cardiovascular autonomic dysfunction. (18639353)
2009
19
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism-predominant multiple system atrophy. (19514077)
2009
20
Effect of hemodialysis on autonomic dysfunction in patients with chronic renal failure - biomed 2009. (19369776)
2009
21
Cardiovascular and sudomotor autonomic dysfunction in Wilson's disease--limited correlation with clinical severity. (19665943)
2009
22
Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. (18378616)
2008
23
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
24
Autoantibodies to calcium channels in type 1 diabetes mediate autonomic dysfunction by different mechanisms in colon and bladder and are neutralized by antiidiotypic antibodies. (18472396)
2008
25
Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. (18248583)
2008
26
Long-term transvenous temporary pacing with active fixation bipolar lead in the management of severe autonomic dysfunction in Miller-Fisher syndrome: a case report. (17267055)
2007
27
Autonomic dysfunction in autoimmune diseases: consequence or cause? (17728374)
2007
28
Cardiovascular autonomic dysfunction in dementia with Lewy bodies and Parkinson's disease. (17306830)
2007
29
Cardiac autonomic dysfunction and functional outcome after ischaemic stroke. (17662015)
2007
30
Association between cardiac autonomic dysfunction and inflammation in type 1 diabetic patients: effect of beta-blockade. (17371783)
2007
31
Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks. (17325646)
2007
32
Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction. (16698188)
2006
33
A new wrinkle: skin manifestations of aging may relate to autonomic dysfunction. (16766136)
2006
34
Heart rate variability and autonomic dysfunction in SSPE. (15730899)
2005
35
Effect of allopurinol on autonomic dysfunction in rat jejunal segments exposed to cold ischemic preservation for transplantation. (15050137)
2004
36
Monophasic negative sympathetic skin responses and autonomic dysfunction in carpal tunnel syndrome. (14755503)
2004
37
Autonomic dysfunction in peripheral nerve disease. (12766975)
2003
38
Location-dependent patterns in cardio-autonomic dysfunction in ischaemic stroke. (12824710)
2003
39
Autonomic dysfunction in Parkinson's disease. (12774210)
2003
40
Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey. (12039423)
2002
41
Regulation of cerebral blood flow in patients with autonomic dysfunction and severe postural hypotension. (12402445)
2002
42
Prevalence of autonomic dysfunction in cirrhotic and noncirrhotic portal hypertension. (11922567)
2002
43
Autonomic dysfunction in movement disorders. (11470968)
2001
44
Autonomic dysfunction associated with multiple pelvic ganglioneuromas. (11442444)
2001
45
Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates. (11374094)
2001
46
Severe cardiovascular autonomic dysfunction in a patient with Guillain-Barre syndrome: a case report. (11269930)
2000
47
Autonomic dysfunction and urinary albumin excretion rate are associated with an abnormal blood pressure pattern in normotensive normoalbuminuric type 1 diabetic patients. (10895852)
2000
48
Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects. (10342819)
1999
49
Autonomic dysfunction in chronic intestinal pseudo-obstruction. (9869551)
1998
50
Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). (8119549)
1994

Variations for Autonomic Dysfunction

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Expression for genes affiliated with Autonomic Dysfunction

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Expression patterns in normal tissues for genes affiliated with Autonomic Dysfunction

Search GEO for disease gene expression data for Autonomic Dysfunction.

Pathways for genes affiliated with Autonomic Dysfunction

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Pathways related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4ARSH, GLA
29.2PHOX2B, MECP2, ECE1

Compounds for genes affiliated with Autonomic Dysfunction

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Compounds related to Autonomic Dysfunction according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1catecholamine449.7HCRT, ARSH
2cerebroside449.7ARSH, GLA
3dopamine44 28 24 1112.4ARSH, PHOX2B, HCRT
4cholesterol44 28 24 1112.4ECE1, HCRT, ARSH
5zinc44 2410.3ECE1, ARSH, MECP2
6oligonucleotide449.3HCRT, MECP2, ECE1
7testosterone44 61 24 1112.2MECP2, ARSH, HCRT
8nitric oxide44 24 1111.1GLA, ECE1, HCRT
9arginine449.1ARSH, MECP2, GLA
10alanine449.0HCRT, MECP2, PHOX2B
11glucose449.0HCRT, ECE1, GLA
12glutamate448.9GLA, HCRT, MECP2
13folate448.8MECP2, SHMT1
14methionine448.8MECP2, GLA, SHMT1
15serine448.5ECE1, ARSH, GLA, SHMT1
16calcium44 50 24 1111.4ARSH, HCRT, GLA, ECE1

GO Terms for genes affiliated with Autonomic Dysfunction

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Biological processes related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of respiratory gaseous exchange by neurological system processGO:0020879.5PHOX2B, MECP2
2sphingolipid metabolic processGO:0066659.4ARSH, GLA
3regulation of excitatory postsynaptic membrane potentialGO:0600799.3MECP2, HCRT
4glycosphingolipid metabolic processGO:0066879.1ARSH, GLA

Molecular functions related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428038.7GLA, SHMT1, ECE1

Products for genes affiliated with Autonomic Dysfunction

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Sources for Autonomic Dysfunction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet