Autonomic Dysfunction malady

NINDS: Dysautonomia refers to a disorder of autonomic nervous system (ANS) function. Most physicians view dysautonomia in terms of failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive ANS activities also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.³¹

MalaCards: Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to hirschsprung disease, cardiac defects, and autonomic dysfunction and postural hypotension. An important gene associated with Autonomic Dysfunction is ECE1 (endothelin converting enzyme 1), and among its related pathways are IRS activation and Adipocytokines & Insulin Signaling. The compounds glucose and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include heart and hypothalamus, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Wikipedia: Dysautonomia (or autonomic dysfunction) is a broad term that describes any disease or malfunction of the...⁴⁴ more...

autonomic dysfunction 31 43 autonomic nervous system disorders 43

autonomic disorder 32

Diseases related to autonomic dysfunction by text searches and GeneDecks gene sharing:

(show top 50)    (show all 516)

id	Related Disease	Score	Top Affiliating Genes
1	hirschsprung disease, cardiac defects, and autonomic dysfunction	31.6	MME, MMEL1, PHEX, ECE1
2	postural hypotension	28.7	REN, INS, EPO
3	hirschsprung's disease	28.7	UCHL1, MME, MMEL1, PHEX, PHOX2B, NPY
4	pure autonomic failure	27.4	REN, SNCA
5	ankylosing spondylitis	27.1	INS, IL6, APOA1, CRP, RPS27A, ADIPOQ
6	spasticity	27.0	MTHFR, ATXN3, INS, MECP2, MAPT, CRP
7	autonomic neuropathy	26.1	REN, INS, FAM134B, ALB, SPTLC2, TTR
8	spondylitis	25.9	INS, IL6, APOA1, ALB, CRP, RPS27A
9	diarrhea	25.9	REN, MME, INS, IL6, ALB, CRP
10	ataxia	25.7	SERPINE1, ATXN3, ATXN2, INS, GSN, MECP2
11	multiple system atrophy	25.4	BDNF, UCHL1, ATXN3, ATXN2, IL6, MAPT
12	insulin resistance	24.1	REN, SERPINE1, BDNF, MTHFR, INS, INSR
13	type 2 diabetes mellitus	23.9	SERPINE1, MTHFR, INS, INSR, IL6, APOA1
14	diabetic retinopathy	23.3	SERPINE1, MTHFR, MME, INS, INSR, IL6
15	anemia	23.0	REN, MTHFR, MME, INS, IL6, F5
16	nephropathy	21.7	REN, SERPINE1, MTHFR, MME, INS, IL6
17	acute myocardial infarction	21.7	REN, SERPINE1, MTHFR, MME, INS, IL6
18	retinitis	20.0	SERPINE1, BDNF, UCHL1, MTHFR, ATXN2, ARSH
19	diabetes mellitus	19.8	REN, SERPINE1, BDNF, MTHFR, INS, INSR
20	myocardial infarction	19.8	REN, SERPINE1, BDNF, MTHFR, MME, INS
21	olivopontocerebellar atrophy	13.7	ATXN3, ATXN2
22	gangliosidosis	13.6	ARSH, GLA, HEXB
23	hereditary sensory and autonomic neuropathy type ii	13.6	FAM134B, WNK1
24	spinocerebellar degeneration	13.6	ATXN3, ATXN2, RPS27A
25	dentatorubral-pallidoluysian atrophy	13.5	ATXN3, ATXN2, RPS27A
26	lattice corneal dystrophy type ii	13.5	GSN, TTR
27	inclusion body myopathy	13.5	MME, SNCA, RPS27A
28	horseshoe kidney	13.4	REN, MME, EPO
29	amyloid neuropathy	13.4	GSN, APOA1, TTR
30	familial transthyretin amyloidosis	13.4	GSN, APOA1, TTR
31	hereditary amyloidosis	13.4	GSN, APOA1, TTR
32	spinocerebellar ataxia type 3	13.4	ATXN3, ATXN2, SNCA, RPS27A
33	anxiety disorder	13.4	BDNF, CRHR2, NPY, GAL
34	hyporeninemic hypoaldosteronism	13.4	REN, INS
35	logopenic progressive aphasia	13.4	MAPT, SNCA
36	frontotemporal dementia, ubiquitin-positive	13.4	MAPT, SNCA
37	inclusion body myositis	13.4	MME, MAPT, RPS27A
38	normal pressure hydrocephalus	13.3	MAPT, HCRT, NPY
39	adult acute lymphocytic leukemia	13.3	MTHFR, MME, SHMT1
40	eating disorder	13.3	BDNF, CRHR2, HCRT, NPY, GAL
41	parkinson's disease	13.3	UCHL1, MAPT, SNCA
42	mood disorder	13.3	BDNF, CRHR2, HCRT, NPY, GAL
43	drug dependence	13.3	BDNF, MME, SNCA, CRHR2, NPY
44	primary progressive aphasia	13.3	MAPT, RPS27A
45	niemann-pick disease type c1	13.3	MAPT, SNCA, HCRT
46	amyloidosis, secondary	13.3	APOA1, CRP, TTR
47	morbid obesity	13.3	INS, HCRT, ADIPOQ
48	mucopolysaccharidosis	13.3	ARSH, MAPT, GLA, HEXB
49	chorea	13.2	BDNF, CRP, RPS27A, NPY
50	hereditary sensory neuropathy	13.2	BDNF, SCN9A, FAM134B, SPTLC2, WNK1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to autonomic dysfunction:

²²

MGI Mouse Phenotypes related to autonomic dysfunction:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	ATXN2, GSN, MECP2, HEXB, GAL
2	hematopoietic system phenotype	MP:0005397	9.6	UCHL1, GSN, HEXB, EPO, TCF4
3	respiratory system phenotype	MP:0005388	9.2	BDNF, GSN, INSR, MECP2, PHOX2B, HCRT
4	reproductive system phenotype	MP:0005389	9.1	GAL, ADIPOQ, SNCA, IL6, MECP2, REN
5	integument phenotype	MP:0010771	8.7	F5, SNCA, MAPT, MECP2, GSN, MME
6	liver/biliary system phenotype	MP:0005370	8.5	SHMT1, SPTLC2, GLA, APOA1, IL6, INS
7	skeleton phenotype	MP:0005390	8.4	IL6, MTHFR, INS, ECE1, HEXB, PHEX
8	renal/urinary system phenotype	MP:0005367	8.3	PHEX, GLA, MAPT, WNK1, HEXB, INSR
9	vision/eye phenotype	MP:0005391	7.9	CRHR2, HMGB1, INS, MTHFR, IL6, MAPT
10	adipose tissue phenotype	MP:0005375	7.9	MECP2, INSR, INS, ATXN2, PHEX, NPY
11	immune system phenotype	MP:0005387	7.7	HEXB, PHEX, CRHR2, MAPT, APOA1, GSN
12	muscle phenotype	MP:0005369	7.4	NPPB, ADIPOQ, ECE1, HEXB, HCRT, MAPT
13	digestive/alimentary phenotype	MP:0005381	7.0	INS, INSR, IL6, ALB, SNCA, PHEX
14	nervous system phenotype	MP:0003631	6.7	INS, HCRT, ATXN3, MTHFR, SCN9A, BDNF
15	mortality/aging	MP:0010768	6.6	SPTLC2, BDNF, GSN, ATXN2, MTHFR, UCHL1
16	growth/size phenotype	MP:0005378	6.2	HCRT, TCF4, IL6, ADIPOQ, WNK1, NPY
17	cellular phenotype	MP:0005384	5.8	ADIPOQ, GAL, BDNF, INS, INSR, GSN
18	behavior/neurological phenotype	MP:0005386	5.7	HCRT, SCN9A, SNCA, HMGB1, F5, MAPT
19	cardiovascular system phenotype	MP:0005385	5.6	F5, SERPINE1, REN, APOA1, GSN, INSR
20	homeostasis/metabolism phenotype	MP:0005376	3.3	SERPINE1, HMGB1, ALB, F5, APOA1, IL6

Articles related to autonomic dysfunction:

(show all 40)

id	Title	Authors	Year	Affiliating Genes
1	Autonomic dysfunction with mutations in the gene that encodes methyl-CpG-binding protein 2: insights into Rett syndrome. (21316312)	Lioy D.T.... Bissonnette J.M.	2011	MECP2
2	Massive expansion of SCA2 with autonomic dysfunction, retinitis pigmentosa, and infantile spasms. (21880993)	Paciorkowski A.R.... Gomez C.M.	2011	ATXN2
3	Autonomic dysfunction is associated with high mobilit y group box-1 levels in patients after acute myocardial infarction. (19651408)	Giallauria F.... Vigorito C.	2010	HMGB1
4	Perivascular nerve fiber alpha-synuclein regulates co ntractility of mouse aorta: a link to autonomic dysfunction in Parkinson's dise ase. (20420875)	Marrachelli V.G.... PAcrez-SA!nchez F.	2010	SNCA
5	Dorsal motor nucleus of vagus protein aggregates in L ewy body disease with autonomic dysfunction. (19501577)	Miller V.M.... Allan L.M.	2009	SNCA, RPS27A
6	Diabetic retinopathy is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. (19262488)	Anan F.... Yoshimatsu H.	2009	INS
7	Autonomic dysfunction and neuropeptide Y in fibromyal gia. (20074444)	Di Franco M.... Valesini G.	2009	NPY
8	The paraventricular nucleus of the hypothalamus - a p otential target for integrative treatment of autonomic dysfunction. (18479218)	Ferguson A.V.... Samson W.K.	2008	ADIPOQ, HCRT
9	Role of interleukin-6 levels in cardiovascular autonomic dysfunction in type 2 diabetic patients. (18449539)	Shinohara T.... Yoshimatsu H.	2008	IL6
10	Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. (18378616)	Baccarelli A.... Schwartz J.	2008	MTHFR, SHMT1
11	The autonomic dysfunction in patients with ankylosing spondylitis: a clinical and electrophysiological study. (18463935)	Borman P.... Yorgancioglu Z.R.	2008	CRP
12	Cardiovascular autonomic dysfunction in patients with movement disorders. (18540148)	Walter B.L.	2008	SNCA
13	Mutations in TCF4, encoding a class I basic helix-loop-helix transcription factor, are responsible for Pitt-Hopkins syndrome, a severe epileptic encephalopathy associated with autonomic dysfunction. (17436254)	Amiel J.... Colleaux L.	2007	TCF4
14	The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. (17463411)	Chuang K.J.... Tang C.S.	2007	SERPINE1
15	Contrast nephropathy may be partly mediated by autonomic dysfunction: renal failure considered as a modern maladaptation of the prehistoric trauma response. (16330157)	Yun A.J.... Lee P.Y.	2006	REN
16	Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction. (16254496)	Paterson D.S.... Kinney H.C.	2005	BDNF, MECP2
17	Pediatric disorders with autonomic dysfunction: what role for PHOX2B? (15901893)	Gaultier C.... Gallego J.	2005	PHOX2B
18	Autonomic dysfunction in ALS: a preliminary study on the effects of intrathecal BDNF. (16036433)	Beck M.... Naumann M.	2005	BDNF
19	High-sensitivity C-reactive protein is associated with insulin resistance and cardiovascular autonomic dysfunction in type 2 diabetic patients. (15798966)	Anan F.... Yoshimatsu H.	2005	CRP
20	Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction. (16249188)	Trochet D.... Amiel J.	2005	PHOX2B
21	Reversible autonomic dysfunction in a young woman with septic multiple organ dysfunction syndrome (15776347)	Schmidt H.... Werdan K.	2005	F5, CRP
22	Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study. (15486117)	Shehab A.M.... Struthers A.D.	2004	NPPB
23	Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation. (15704871)	Dotti M.T.... Federico A.	2004	MECP2
24	The shortest expanded allele of the MJD1 gene in a Chinese MJD kindred with autonomic dysfunction. (15316156)	Gu W.... Shen Y.	2004	ATXN3
25	Microalbuminuria, cardiovascular autonomic dysfunction, and insulin resistance in patients with type 2 diabetes mellitus. (15375795)	Takahashi N.... Yoshimatsu H.	2004	ALB, INS
26	Autonomic dysfunction in peripheral nerve disease. (12766975)	Low P.A.... Suarez G.	2003	GSN, APOA1, TTR
27	Early autonomic dysfunction in glucose-tolerant but insulin-resistant offspring of type 2 diabetic patients. (12743012)	Frontoni S.... Gambardella S.	2003	INS
28	Physiologic assessment of autonomic dysfunction in pallidopontonigral degeneration with N279K mutation in the tau gene on chromosome 17. (12492138)	Cheshire W.P.... Wszolek Z.K.	2002	MAPT
29	Autonomic dysfunction and urinary albumin excretion rate are associated with an abnormal blood pressure pattern in normotensive normoalbuminuric type 1 diabetic patients. (10895852)	Pecis M.... Gross J.L.	2000	ALB
30	Decreased prorenin processing develops before autonomic dysfunction in type 1 diabetes. (10690859)	Hoeldtke R.D.... Hobbs G.R.	2000	REN
31	Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects. (10342819)	Laitinen T.... Laakso M.	1999	INSR, INS
32	A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction. (9915973)	Hofstra R.M.W.... Buys C.H.C.M.	1999	ECE1
33	Idiopathic hypovolemia: a self-perpetuating autonomic dysfunction? (9869552)	Kuchel O.... LAcveillAc J.	1998	ARSH
34	Machado-Joseph disease: cerebellar ataxia and autonomic dysfunction in a patient with the shortest known expanded allele (56 CAG repeat units) of the MJD1 gene. (9270607)	Takiyama Y.... Nishizawa M.	1997	ATXN3
35	Erythropoietin treatment for postural hypotension from autonomic dysfunction. (9028529)	Nair B.... Black A.	1996	EPO
36	Autonomic dysfunction and anemia in neurologic disorders. (8946333)	Ando Y.... Ando M.	1996	EPO
37	Abnormal myocardial uptake and clearance of 123I-labeled metaiodobenzylguanidine in patients with chronic renal failure and autonomic dysfunction. (8989675)	Miyanaga H.... Kunishige H.	1996	CRHR2
38	Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). (8119549)	Modigliani R.... Poitras P.	1994	HEXB
39	Plasma neuropeptide Y (NPY) and galanin before and during exercise in type 1 diabetic patients with autonomic dysfunction. (1374311)	Sundkvist G.... AhrAcn B.	1992	NPY, GAL
40	Autonomic dysfunction in metabolic diseases (1619765)	Sakakihara Y.	1992	GLA

Genes related to autonomic dysfunction according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	ECE1	endothelin converting enzyme 1	11.1	Summaries, Publications
2	MMEL1	membrane metallo-endopeptidase-like 1	11.0	Orthologs
3	MME	membrane metallo-endopeptidase	11.0	Orthologs
4	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0	Orthologs
5	PHOX2B	paired-like homeobox 2b	11.0	Publications
6	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications
7	HEXB	hexosaminidase B (beta polypeptide)	11.0	Publications
8	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0
9	ARSH	arylsulfatase family, member H	11.0	Publications
10	ATXN3	ataxin 3	11.0	Publications
11	GSN	gelsolin	11.0	Publications
12	HCRT	hypocretin (orexin) neuropeptide precursor	11.0	Publications
13	HMGB1	high mobility group box 1	11.0	Publications
14	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0	Publications
15	ATXN2	ataxin 2	11.0	Publications
16	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	11.0
17	GLA	galactosidase, alpha	11.0	Publications
18	CRHR2	corticotropin releasing hormone receptor 2	11.0	Publications
19	FAM134B	family with sequence similarity 134, member B	11.0
20	GAL	galanin prepropeptide	11.0	Publications
21	WNK1	WNK lysine deficient protein kinase 1	11.0
22	NPY	neuropeptide Y	11.0	Publications
23	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
24	TTR	transthyretin	11.0	Publications
25	REN	renin	11.0	Publications
26	RPS27A	ribosomal protein S27a	11.0	Publications
27	SCN9A	sodium channel, voltage-gated, type IX, alpha subunit	11.0
28	TCF4	transcription factor 4	11.0	Publications
29	BDNF	brain-derived neurotrophic factor	11.0	Publications
30	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
31	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
32	CRP	C-reactive protein, pentraxin-related	11.0	Publications
33	INS	insulin	11.0	Publications
34	EPO	erythropoietin	11.0	Publications
35	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
36	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
37	NPPB	natriuretic peptide B	11.0	Publications
38	MAPT	microtubule-associated protein tau	11.0	Publications
39	APOA1	apolipoprotein A-I	11.0	Publications
40	INSR	insulin receptor	11.0	Publications
41	ALB	albumin	11.0	Publications
42	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications

Pathways related to autonomic dysfunction according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	IRS activation38	9.6	INS, INSR
2	Adipocytokines & Insulin Signaling37	8.9	INS, INSR, ADIPOQ
3	Selected targets of HNF110	8.4	INS, APOA1, ALB, CRP

Compounds related to autonomic dysfunction according to GeneDecks:

(show top 50)    (show all 232)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	GLA, GSN, MME
2	ascorbic acid32 18	10.8	MME, BDNF, EPO, TTR
3	aspartate32	9.4	PHEX, RPS27A, GLA, F5, APOA1, BDNF
4	gnrh32	9.4	HCRT, SERPINE1, INS, MME, CRHR2, NPY
5	c-peptide32	9.2	HCRT, GAL, ADIPOQ, INSR
6	catecholamine32	9.1	GAL, NPY, GSN, NPPB, HCRT, SNCA
7	fosinopril32 9 9	10.8	CRP, MME, NPPB, ALB, SERPINE1, REN
8	pioglitazone32 9 9	10.6	INS, INSR, ADIPOQ, NPPB, APOA1
9	methionine32	8.6	GAL, BDNF, MTHFR, TTR, SHMT1, SNCA
10	octreotide32 42 9 9	11.5	ADIPOQ, MME, INS, INSR, NPY, GAL
11	valsartan32 42 9 9	11.5	REN, CRP, NPPB, ADIPOQ, ALB, SERPINE1
12	vitamin b632	8.4	F5, TTR, SHMT1, MTHFR, ALB, CRP
13	telmisartan32 9 9	10.4	NPPB, ALB, INS, REN, CRP, ADIPOQ
14	acth32	8.4	MME, BDNF, INS, REN, GAL, NPY
15	ramipril32 9 9	10.3	NPPB, REN, SERPINE1, INS, ADIPOQ, CRP
16	sodium dodecylsulfate32	8.2	SERPINE1, TTR, RPS27A, SNCA, ALB, MAPT
17	adenylate32	8.2	GAL, SERPINE1, ADIPOQ, RPS27A, NPY, TTR
18	heparin32 9 18 9	11.0	SERPINE1, ADIPOQ, SNCA, HMGB1, ALB, MAPT
19	tacrolimus32 34 9 9	11.0	RPS27A, SNCA, SERPINE1, NPPB, INS, F5
20	enalapril32 9 9	9.9	SERPINE1, MME, APOA1, EPO, NPPB, REN
21	fenofibrate32 9 9	9.9	ADIPOQ, CRP, APOA1, INSR, IL6, INS
22	metformin32 34 9 9	10.9	ADIPOQ, APOA1, INSR, F5, INS, MTHFR
23	arginine32	7.9	ADIPOQ, REN, MME, ARSH, MECP2, MAPT
24	glutamate32	7.8	GLA, MAPT, MECP2, GSN, INSR, INS
25	norepinephrine32 9 18 9	10.6	TTR, HCRT, PHOX2B, CRP, NPY, SNCA
26	dopamine32 9 18 9	10.6	CRHR2, SNCA, MAPT, INSR, ARSH, MME
27	prostacyclin32	7.6	ADIPOQ, REN, NPY, ECE1, NPPB, CRP
28	vitamin b1232	7.6	F5, APOA1, MAPT, ALB, CRP, TTR
29	epinephrine32 9 18 9	10.4	NPY, NPPB, HCRT, INSR, REN, TTR
30	indomethacin32 9 9	9.4	REN, BDNF, MME, IL6, APOA1, ALB
31	folate32	7.4	ALB, TTR, SHMT1, CRP, F5, MTHFR
32	glycogen32 18	8.4	RPS27A, SNCA, NPPB, GLA, MAPT, GSN
33	aspirin32 34 18	9.3	NPPB, ADIPOQ, TTR, RPS27A, CRP, F5
34	homocysteine32 18	8.3	NPPB, ADIPOQ, SERPINE1, MTHFR, F5, APOA1
35	thyroxine32 18	8.1	NPPB, TTR, HCRT, ALB, APOA1, INSR
36	uric acid32 18	8.1	SERPINE1, MTHFR, INS, APOA1, F5, ALB
37	cysteine32	7.1	UCHL1, ALB, GSN, INSR, MAPT, MTHFR
38	acetylcholine32 9 18 9	9.9	BDNF, MME, INSR, APOA1, MAPT, HMGB1
39	fibrinogen32	6.7	ADIPOQ, IL6, APOA1, F5, HMGB1, CRP
40	vitamin d32	6.7	GSN, PHEX, INSR, TTR, NPPB, ADIPOQ
41	dexamethasone32 42 34 9 9	10.6	IL6, REN, SERPINE1, MME, INS, INSR
42	creatinine32	6.6	EPO, REN, BDNF, MTHFR, ADIPOQ, NPY
43	retinoic acid32 42 18	8.5	NPY, MAPT, APOA1, F5, HMGB1, RPS27A
44	estrogen32	6.4	HCRT, SERPINE1, ADIPOQ, NPY, NPPB, TTR
45	alanine32	6.3	GAL, ADIPOQ, NPY, TTR, PHOX2B, CRP
46	testosterone32 9 18 9	9.2	F5, MAPT, APOA1, GSN, INSR, BDNF
47	cholesterol32 9 18 9	8.9	ARSH, INS, IL6, APOA1, F5, ALB
48	lactate32	5.5	GLA, ALB, F5, MAPT, APOA1, IL6
49	lipid32	5.4	CRP, HMGB1, SERPINE1, NPPB, GLA, ALB
50	serine32	5.1	NPPB, TTR, SHMT1, RPS27A, SNCA, SPTLC2

Cellular components related to autonomic dysfunction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	perinuclear region of cytoplasm	GO:048471	9.3	ATXN2, GSN, SNCA, PHEX, HCRT, NPPB
2	secretory granule	GO:030141	9.1	GAL, HCRT, APOA1, INS
3	extracellular space	GO:005615	5.5	CRP, TTR, NPPB, NPY, ADIPOQ, EPO
4	extracellular region	GO:005576	4.8	SERPINE1, CRP, HCRT, TTR, NPPB, NPY

Biological processes related to autonomic dysfunction according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of excitatory postsynaptic membrane potential	GO:060079	10.2	HCRT, SNCA, MECP2
2	axon target recognition	GO:007412	10.1	UCHL1, BDNF
3	sphingolipid metabolic process	GO:006665	10.1	ARSH, GLA, SPTLC2, HEXB
4	blood circulation	GO:008015	9.6	EPO, NPY, F5, MTHFR
5	glucocorticoid metabolic process	GO:008211	9.5	APOA1, MECP2
6	positive regulation of respiratory burst	GO:060267	9.5	INS, INSR
7	response to hypoxia	GO:001666	9.4	ADIPOQ, ECE1, NPPB, CRP, MECP2
8	positive regulation of glucose import	GO:046326	9.3	ADIPOQ, INSR, INS
9	glucose homeostasis	GO:042593	9.2	SERPINE1, INS, INSR, ADIPOQ
10	response to glucocorticoid stimulus	GO:051384	8.8	ADIPOQ, HMGB1, IL6, INSR, SERPINE1
11	platelet degranulation	GO:002576	8.6	ALB, F5, APOA1, SERPINE1

Molecular functions related to autonomic dysfunction according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	9.7	NPY, GAL, HCRT
2	insulin-like growth factor receptor binding	GO:005159	9.3	REN, INS, INSR
3	receptor binding	GO:005102	8.9	REN, ADIPOQ, NPY, NPPB, GLA, SERPINE1
4	hormone activity	GO:005179	8.8	CRHR2, EPO, ADIPOQ, NPPB, TTR, INS
5	protein binding	GO:005515	4.3	CRHR2, INSR, MECP2, APOA1, MAPT, F5