MCID: ATN005
MIFTS: 39

Autonomic Dysfunction malady

Neuronal diseases category

Summaries for Autonomic Dysfunction

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function. Most physicians view dysautonomia in terms of failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive ANS activities also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards: Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to parkinson's disease and multiple sclerosis. An important gene associated with Autonomic Dysfunction is ECE1 (endothelin converting enzyme 1), and among its related pathways are Glycosphingolipid biosynthesis - globo series and A-beta Uptake & Degradation. The compounds sampatrilat and galp have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:63 Dysautonomia (or autonomic dysfunction) is any disease or malfunction of the autonomic nervous system... more...

Aliases & Classifications for Autonomic Dysfunction

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43NINDS, 60UMLS, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autonomic dysfunction 43 60
autonomic nervous system disorders 60
autonomic disorder 44


Related Diseases for Autonomic Dysfunction

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17GeneCards, 18GeneDecks
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Diseases in the Autonomic Dysfunction family:

Autonomic Neuropathy

Diseases related to Autonomic Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 225)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.0GAL, SNCA, ATXN2, HCRT
2multiple sclerosis30.8NPY, HCRT, MME
3diabetes mellitus30.7REN, NPY
4multiple system atrophy30.6ATXN3, SNCA
5obesity30.6NPY, GAL, CRHR2, ATXN3, HCRT
6dementia30.5HCRT, SNCA, GAL
7myocardial infarction30.3NPY, ECE1, GLA, REN, MME
8hepatitis30.2GAL
9sleep disorder30.2HCRT
10arthritis30.2HMGB1, GAL
11schizophrenia30.2NPY, MECP2, SNCA, HCRT
12pure autonomic failure30.2REN, SNCA
13rheumatoid arthritis30.1HMGB1, MME
14alzheimer's disease30.1NPY, GAL, SNCA, ECE1, HCRT, MME
15hirschsprung's disease29.9NPY, PHOX2B, ECE1
16olivopontocerebellar atrophy29.9ATXN2, SNCA
17anorexia nervosa29.9NPY, GAL, HCRT
18down syndrome29.9SNCA, MECP2, GAL
19myopathy29.9GSN
20spinocerebellar ataxia29.9ATXN3, ATXN2, SNCA
21ganglioneuroma29.9SNCA, GAL, NPY
22brain disease29.9MECP2, SNCA, HCRT
23huntington's disease29.9NPY, SNCA, ATXN3, HCRT
24eating disorder29.9NPY, GAL, CRHR2, HCRT
25cystic fibrosis29.9GSN, MME
26breast cancer29.9GAL, ARSH, MECP2, SNCA, SHMT1, ECE1
27hypertension10.6
28autonomic neuropathy10.4
29stroke, ischemic10.4
30neuropathy10.4
31chagas disease10.3
32type 2 diabetes mellitus10.3
33cerebritis10.3
34liver disease10.3
35machado-joseph disease10.2
36lewy body dementia10.2
37type 1 diabetes mellitus10.2
38riley-day syndrome10.2
39diabetic autonomic neuropathy10.2
40diabetic neuropathy10.2
41glaucoma10.2
42tetanus10.2
43lambert-eaton myasthenic syndrome10.2
44primary biliary cirrhosis10.2
45brugada syndrome10.2
46carpal tunnel syndrome10.2
47portal hypertension10.2
48polyneuropathy10.2
49rhinitis10.2
50uremia10.2

Graphical network of the top 20 diseases related to Autonomic Dysfunction:



Diseases related to autonomic dysfunction

Clinical Features for Autonomic Dysfunction

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Drugs & Therapeutics for Autonomic Dysfunction

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autonomic Dysfunction

Drug clinical trials:

Search ClinicalTrials for Autonomic Dysfunction

Search NIH Clinical Center for Autonomic Dysfunction

Search CenterWatch for Autonomic Dysfunction

Genetic Tests for Autonomic Dysfunction

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Anatomical Context for Autonomic Dysfunction

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32MalaCards
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MalaCards organs/tissues related to Autonomic Dysfunction:

32
Heart

Animal Models for Autonomic Dysfunction or affiliated genes

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36MGI
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Publications for Autonomic Dysfunction

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Genetic Variations for Autonomic Dysfunction

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Expression for genes affiliated with Autonomic Dysfunction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autonomic Dysfunction

Search GEO for disease gene expression data for Autonomic Dysfunction.

Pathways for genes affiliated with Autonomic Dysfunction

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29KEGG, 52R&D Systems, 53Reactome
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Pathways related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GLA, HEXB
210.2MMEL1, MME, ECE1
3
Hide members
10.1GLA, ARSH, HEXB

Compounds for genes affiliated with Autonomic Dysfunction

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Autonomic Dysfunction according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1sampatrilat4410.6REN, MME
2galp4410.5NPY, HCRT, GAL
3octadecaneuropeptide4410.5NPY, GAL, HCRT
4enterostatin4410.5HCRT, GAL, NPY
5phosphoramidon44 1111.5MME, ECE1, NPY
6lisinopril44 11 2412.5MME, NPY, REN
7trifluoroethanol44 1111.4GAL, NPY, GSN
8tetrodotoxin44 59 2812.4NPY, HCRT, GAL, MME
9opiate4410.4MME, HCRT, GAL, NPY
10atropine44 28 1112.4GAL, MME, NPY, SNCA
11amphetamine44 1111.4NPY, SNCA, HCRT, GAL
12captopril44 28 49 59 1114.3ECE1, REN, MME
13corticosterone44 59 2412.3NPY, GAL, HCRT, REN
14gnrh4410.3HCRT, CRHR2, ARSH, GAL, MME
155-hydroxytryptamine4410.3NPY, GAL, HCRT, MME
16cyclo(his-pro)4410.3GAL, NPY
17cocaine44 1111.3SNCA, NPY, GAL, HCRT
18carbachol44 28 1112.2NPY, GAL, SNCA, HCRT
19prostacyclin4410.2NPY, ECE1, REN, MME
20dsip4410.2GAL, NPY
21acth4410.1REN, MME, NPY, HCRT, CRHR2, GAL
22norepinephrine44 11 2412.1NPY, GAL, PHOX2B, SNCA, HCRT, REN
23secretoneurin4410.1GAL, NPY
24serine4410.1HMGB1, GLA, ECE1, SNCA, ARSH, GAL
25acetylcholine44 49 28 11 2414.1HCRT, HMGB1, MME, GAL, NPY, SNCA
26sodium44 2411.1GSN, PHEX, REN, MME, GAL, HCRT
27clonidine44 28 1112.1NPY, REN, GAL
28polyacrylamide4410.1ATXN2, ATXN3, HMGB1, GAL, GSN, HEXB
29methionine4410.1MME, MECP2, SNCA, SHMT1, GAL, GLA
30lysine4410.1HMGB1, MME, SNCA, SHMT1, GAL, GSN
31hydrogen44 2411.0GAL, ARSH, GLA, MME, SNCA
32glutamine4410.0PHOX2B, SNCA, ATXN2, ATXN3, NPY
33phosphatidylserine44 28 1112.0GAL, GSN, HMGB1, SNCA
34catecholamine4410.0HCRT, NPY, SNCA, GAL, GSN, ARSH
35cholesterol44 28 11 2413.0HMGB1, REN, ECE1, SNCA, ARSH, HCRT
36steroid4410.0HMGB1, REN, MME, ARSH, ECE1, GSN
37adenylate4410.0NPY, GSN, GAL, HCRT, SNCA, MME
38oligonucleotide449.9GSN, GAL, HCRT, ECE1, HMGB1, MECP2
39dopamine44 28 11 2412.9NPY, SNCA, ARSH, PHOX2B, GSN, MME
40alanine449.9GAL, HCRT, SNCA, MECP2, PHOX2B, NPY
41helospectin449.9GAL, NPY
42arginine449.9GLA, REN, SNCA, MME, MECP2, GAL
43cysteine449.9SNCA, ATXN3, ECE1, MME, HMGB1, GSN
44lipid449.8HCRT, SNCA, ARSH, GAL, GLA, MME
45nitric oxide44 11 2411.8HCRT, ECE1, HMGB1, MME, REN, GLA
46glutamate449.7NPY, HCRT, GLA, HMGB1, SNCA, GAL
47tyrosine449.7CRHR2, GAL, PHOX2B, ARSH, GSN, MME
48testosterone44 59 11 2412.6SNCA, ATXN3, HMGB1, GSN, MME, MECP2
49glucose449.6REN, HCRT, GSN, HMGB1, MME, GLA
50calcium44 49 11 2412.3PHEX, NPY, ECE1, GSN, HMGB1, MME

GO Terms for genes affiliated with Autonomic Dysfunction

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16Gene Ontology
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Cellular components related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00802110.1MME, HCRT, SNCA
2perinuclear region of cytoplasmGO:0484719.6PHEX, SNCA, ATXN2, ECE1, HCRT, GSN
3Golgi apparatusGO:0057949.6MMEL1, GAL, PHEX, CRHR2, SNCA, ATXN2
4extracellular regionGO:0055769.1NPY, GAL, SNCA, HCRT, GLA, REN

Biological processes related to Autonomic Dysfunction according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.4REN, MME
2glycosphingolipid metabolic processGO:00668710.3GLA, ARSH, HEXB
3negative regulation of histone acetylationGO:03506710.3MECP2, SNCA
4regulation of excitatory postsynaptic membrane potentialGO:06007910.3HCRT, SNCA, MECP2
5positive regulation of receptor recyclingGO:00192110.3SNCA, ECE1
6regulation of respiratory gaseous exchange by neurological system processGO:00208710.3MECP2, PHOX2B
7sphingolipid metabolic processGO:00666510.1GLA, ARSH, HEXB
8angiotensin maturationGO:00200310.1REN, MME
9proteolysisGO:00650810.1PHEX, ECE1, REN, MME, MMEL1
10neuropeptide signaling pathwayGO:0072189.8HCRT, GAL, NPY

Molecular functions related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.1MMEL1, MME, ECE1, PHEX

Products for genes affiliated with Autonomic Dysfunction

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  • Antibodies
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Sources for Autonomic Dysfunction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet