MCID: ATN005
MIFTS: 52

Autonomic Dysfunction malady

Neuronal category

Summaries for Autonomic Dysfunction

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function. Most physicians view dysautonomia in terms of failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive ANS activities also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards: Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to parkinson's disease and sleep disorder. An important gene associated with Autonomic Dysfunction is ECE1 (endothelin converting enzyme 1), and among its related pathways are Glycosphingolipid biosynthesis - globo series and A-beta Uptake & Degradation. The compounds sampatrilat and galp have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Wikipedia:64 Dysautonomia (or autonomic dysfunction) is any disease or malfunction of the autonomic nervous system... more...

Aliases & Classifications for Autonomic Dysfunction

Sources:
44NINDS, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

autonomic dysfunction 44 61
autonomic nervous system disorders 61
autonomic disorder 45


Related Diseases for Autonomic Dysfunction

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Autonomic Dysfunction family:

autonomic neuropathy

Diseases related to Autonomic Dysfunction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.7GAL, SNCA, ATXN2, HCRT
2sleep disorder30.3HCRT
3arthritis30.3HMGB1, GAL
4olivopontocerebellar atrophy29.9ATXN2, SNCA
5anorexia nervosa29.9NPY, GAL, HCRT
6spinocerebellar ataxia29.9ATXN3, ATXN2, SNCA
7ganglioneuroma29.9SNCA, GAL, NPY
8brain disease29.9MECP2, SNCA, HCRT
9huntington's disease29.9NPY, SNCA, ATXN3, HCRT
10pure autonomic failure29.9REN, SNCA
11cystic fibrosis29.9GSN, MME
12insulin resistance10.4
13autonomic neuropathy10.4
14stroke, ischemic10.4
15chagas disease10.4
16dysautonomia10.4
17fibromyalgia10.4
18wilson disease10.3
19guillain-barr� syndrome10.3
20sleep apnea10.3
21machado-joseph disease10.3
22n syndrome10.3
23diabetic autonomic neuropathy10.3
24tetanus10.3
25lambert syndrome10.3
26spinal cord injury10.3
27orthostatic intolerance10.3
28lambert-eaton myasthenic syndrome10.2
29primary biliary cirrhosis10.2
30brugada syndrome10.2
31carpal tunnel syndrome10.2
32portal hypertension10.2
33uremia10.2
34postural orthostatic tachycardia syndrome10.2
35ataxia10.2
36postural hypotension10.2
37pulmonary disease, chronic obstructive10.2
38reflex sympathetic dystrophy10.2
39burning mouth syndrome10.2
40riley-day syndrome10.2
41dysautonomia like disorder10.2
42carotid stenosis10.1
43rett syndrome10.1
44hepatitis c10.1
45temporal lobe epilepsy10.1
46achalasia10.1
47systemic lupus erythematosus10.1
48vasomotor rhinitis10.1
49polycystic ovary syndrome10.1
50muscular atrophy10.1

Graphical network of the top 20 diseases related to Autonomic Dysfunction:



Diseases related to autonomic dysfunction

Clinical Features for Autonomic Dysfunction

Drugs & Therapeutics for Autonomic Dysfunction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autonomic Dysfunction

Drug clinical trials:

Search ClinicalTrials for Autonomic Dysfunction

Search NIH Clinical Center for Autonomic Dysfunction

Search CenterWatch for Autonomic Dysfunction

Genetic Tests for Autonomic Dysfunction

Anatomical Context for Autonomic Dysfunction

Sources:
33MalaCards
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MalaCards organs/tissues related to Autonomic Dysfunction:

33
Brain, Cortex, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Prostate, T cells, B cells, Temporal lobe, Hypothalamus, Adrenal cortex

Animal Models for Autonomic Dysfunction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Autonomic Dysfunction

Sources:
51PubMed
See all sources

Articles related to Autonomic Dysfunction:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Paroxysmal autonomic dysfunction in a patient with chronic rhinosinusitis. (24132043)
2014
2
Nocturnal Anxiety in a Youth with Rapid-onset Obesity, Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD). (23970913)
2013
3
Autonomic dysfunction in children with sleep disordered breathing. (22684854)
2013
4
Cardiovascular autonomic dysfunction in non-obese diabetic mice. (23622812)
2013
5
Autonomic Dysfunction in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy: Biochemical Evidence of Altered Signaling Pathways. (24025189)
2013
6
Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer's disease: a scoping review of the evidence. (24329892)
2013
7
Juvenile cobalamin deficiency in a 17-year-old child with autonomic dysfunction and skin changes. (22082743)
2012
8
Autonomic dysfunction and anti-M2 and anti-I^1 receptor antibodies in Chagas disease patients. (22790404)
2012
9
Links between metabolic syndrome and cardiovascular autonomic dysfunction. (22474426)
2012
10
How to predict the impact of methylphenidate on cardiovascular risk in children with attention deficit disorder: methylphenidate improves autonomic dysfunction in children with ADHD. (22530135)
2012
11
Clinical findings associated with cardiovascular autonomic dysfunction in adult sickle cell anaemia patients. (22641974)
2012
12
Cardiac autonomic dysfunction in hemodialysis patients: The value of heart rate turbulence. (21395968)
2011
13
Effect of deep brain stimulation on autonomic dysfunction in patients with Parkinson's disease. (21489800)
2011
14
Syncope and autonomic cardiovascular dysfunction in Parkinson disease. (22101994)
2011
15
The influence of pediatric autonomic dysfunction on recovery after concussion. (21079448)
2010
16
Successful use of ivabradine in a case of exaggerated autonomic dysfunction. (20935439)
2010
17
Effect of autonomic dysfunction on p-wave dispersion in patients with chronic spinal cord injury. (20855983)
2010
18
Vitamin B12-responsive severe leukoencephalopathy and autonomic dysfunction in a patient with "normal" serum B12 levels. (20587489)
2010
19
Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease. (19768633)
2009
20
Autonomic dysfunction in chronic liver disease. (19323779)
2009
21
Sudomotor dysfunction in autoimmune autonomic ganglionopathy. (19884578)
2009
22
Autonomy of autonomic dysfunction in major depression. (19779146)
2009
23
Migraine is characterized by a cardiac autonomic dysfunction. (18572435)
2008
24
Characterization of autonomic dysfunction in patients with irritable bowel syndrome using fingertip blood flow. (18248583)
2008
25
Does autonomic dysfunction play a role in atopic dermatitis? (18652587)
2008
26
Cardiovascular autonomic dysfunction predicts acute ischaemic stroke in patients with Type 2 diabetes mellitus: a 7-year follow-up study. (19046195)
2008
27
Low-dose steroid alters in vivo endotoxin-induced systemic inflammation but does not influence autonomic dysfunction. (18182463)
2007
28
Autonomic dysfunction and adrenal insufficiency in thoracic spine tuberculosis. (17483731)
2007
29
Autonomic dysfunction in unselected and untreated primary open angle glaucoma patients: a pilot study. (17584284)
2007
30
Autonomic dysfunction in Guillain-BarrAc syndrome and multiple sclerosis. (17503142)
2007
31
Assessment of autonomic dysfunction of multiple system atrophy with laryngeal abductor paralysis as an early manifestation. (17826894)
2007
32
Autonomic dysfunction in left ventricular hypertrabeculation/noncompaction. (15967518)
2006
33
Complex autonomic dysfunction in cardiovascular, intensive care, and schizophrenic patients assessed by autonomic information flow. (17061934)
2006
34
Reversible autonomic dysfunction in a young woman with septic multiple organ dysfunction syndrome]. (15776347)
2005
35
Autonomic dysfunction in dementia with Lewy bodies. (15159482)
2004
36
Autonomic dysfunction in mental retardation and spastic paraparesis with MECP2 mutation. (15704871)
2004
37
Left ventricular dysfunction in normotensive Type 1 diabetic patients: the impact of autonomic neuropathy. (15154934)
2004
38
Frequency and predictors of autonomic dysfunction in Parkinson's disease: a study of African patients in Lagos, Nigeria. (15254572)
2004
39
Assessment of autonomic dysfunction in Parkinson's disease: the SCOPA-AUT. (15390007)
2004
40
Cardiovascular autonomic dysfunction in primary SjAPgren's syndrome. (12949253)
2004
41
Location-dependent patterns in cardio-autonomic dysfunction in ischaemic stroke. (12824710)
2003
42
Preclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetes. (12898473)
2003
43
Revisiting autonomic dysfunction in end-stage renal disease patients. (19379365)
2003
44
Regulation of cerebral blood flow in patients with autonomic dysfunction and severe postural hypotension. (12402445)
2002
45
Genetic disorders as models to understand autonomic dysfunction. (12102457)
2002
46
Cardiac autonomic nervous dysfunction in diabetic patients with a mitochondrial DNA mutation: assessment by heart rate variability. (12453978)
2002
47
Cardiovascular autonomic dysfunction in Africans infected with human immunodeficiency virus. (12205208)
2002
48
Diarrhea and autonomic dysfunction in a patient with hexosaminidase B deficiency (Sandhoff disease). (8119549)
1994
49
Reversible hyporeninaemic hypoaldosteronism and life-threatening cardiac dysrhythmias: the interaction of non-steroidal anti-inflammatory drugs and autonomic dysfunction. (8415355)
1993
50
Gangliosides improve urinary bladder dysfunction in experimental diabetic autonomic neuropathy. (2097626)
1990

Genetic Variations for Autonomic Dysfunction

Expression for genes affiliated with Autonomic Dysfunction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autonomic Dysfunction

Search GEO for disease gene expression data for Autonomic Dysfunction.

Pathways for genes affiliated with Autonomic Dysfunction

Sources:
30KEGG, 53R&D Systems, 54Reactome
See all sources

Pathways related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2GLA, HEXB
210.2MMEL1, MME, ECE1
3
Hide members
10.1GLA, ARSH, HEXB

Compounds for genes affiliated with Autonomic Dysfunction

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Autonomic Dysfunction according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1sampatrilat4510.5REN, MME
2galp4510.5NPY, GAL, HCRT
3octadecaneuropeptide4510.5HCRT, GAL, NPY
4enterostatin4510.5NPY, GAL, HCRT
5phosphoramidon45 1111.5NPY, ECE1, MME
6lisinopril45 11 2412.5NPY, REN, MME
7trifluoroethanol45 1111.4NPY, GAL, GSN
8tetrodotoxin45 60 2912.4NPY, GAL, HCRT, MME
9opiate4510.4MME, HCRT, GAL, NPY
10atropine45 29 1112.4MME, SNCA, GAL, NPY
11amphetamine45 1111.4HCRT, SNCA, GAL, NPY
12captopril45 29 50 60 1114.3ECE1, REN, MME
13corticosterone45 60 2412.3REN, HCRT, GAL, NPY
14gnrh4510.3GAL, ARSH, CRHR2, HCRT, MME
155-hydroxytryptamine4510.3NPY, GAL, HCRT, MME
16cyclo(his-pro)4510.3GAL, NPY
17cocaine45 1111.3NPY, GAL, SNCA, HCRT
18carbachol45 29 1112.2HCRT, SNCA, GAL, NPY
19prostacyclin4510.2MME, REN, ECE1, NPY
20secretoneurin4510.2GAL, NPY
21acth4510.1NPY, GAL, CRHR2, HCRT, REN, MME
22norepinephrine45 11 2412.1NPY, GAL, PHOX2B, SNCA, HCRT, REN
23dsip4510.1GAL, NPY
24serine4510.1GAL, ARSH, SNCA, ECE1, GLA, HMGB1
25acetylcholine45 50 29 11 2414.1NPY, GAL, SNCA, HCRT, MME, HMGB1
26sodium45 2411.1GAL, PHEX, HCRT, REN, MME, GSN
27clonidine45 29 1112.1NPY, GAL, REN
28polyacrylamide4510.1HEXB, GAL, ATXN2, ATXN3, HMGB1, GSN
29methionine4510.1GAL, MECP2, SNCA, SHMT1, GLA, MME
30lysine4510.1GAL, SNCA, SHMT1, MME, HMGB1, GSN
31hydrogen45 2411.0GAL, ARSH, SNCA, GLA, MME
32glutamine4510.0ATXN3, ATXN2, SNCA, PHOX2B, NPY
33phosphatidylserine45 29 1112.0GSN, HMGB1, SNCA, GAL
34catecholamine4510.0NPY, GAL, ARSH, SNCA, HCRT, REN
35cholesterol45 29 11 2413.0ARSH, SNCA, ECE1, HCRT, REN, HMGB1
36steroid4510.0ARSH, ECE1, REN, MME, HMGB1, GSN
37adenylate4510.0NPY, GAL, CRHR2, SNCA, HCRT, MME
38oligonucleotide459.9GAL, MECP2, ECE1, HCRT, HMGB1, GSN
39dopamine45 29 11 2412.9GSN, NPY, PHOX2B, ARSH, SNCA, HCRT
40alanine459.9NPY, GAL, PHOX2B, MECP2, SNCA, HCRT
41helospectin459.9GAL, NPY
42arginine459.9NPY, GAL, ARSH, MECP2, SNCA, GLA
43cysteine459.9ARSH, SNCA, ATXN3, ECE1, MME, HMGB1
44lipid459.8GAL, ARSH, SNCA, HCRT, GLA, MME
45nitric oxide45 11 2411.8NPY, GAL, SNCA, ECE1, HCRT, GLA
46glutamate459.7NPY, GAL, MECP2, SNCA, HCRT, GLA
47tyrosine459.7NPY, GAL, PHOX2B, ARSH, CRHR2, SNCA
48testosterone45 60 11 2412.6NPY, GAL, ARSH, MECP2, SNCA, ATXN3
49glucose459.6NPY, GAL, SNCA, ECE1, HCRT, GLA
50calcium45 50 11 2412.3CRHR2, ARSH, PHEX, GAL, NPY, SNCA

GO Terms for genes affiliated with Autonomic Dysfunction

Sources:
16Gene Ontology
See all sources

Cellular components related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic vesicleGO:00802110.1MME, HCRT, SNCA
2perinuclear region of cytoplasmGO:0484719.6PHEX, SNCA, ATXN2, ECE1, HCRT, GSN
3Golgi apparatusGO:0057949.6MMEL1, GAL, PHEX, CRHR2, SNCA, ATXN2
4extracellular regionGO:0055769.1NPY, GAL, SNCA, HCRT, GLA, REN

Biological processes related to Autonomic Dysfunction according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1beta-amyloid metabolic processGO:05043510.4REN, MME
2glycosphingolipid metabolic processGO:00668710.3GLA, ARSH, HEXB
3negative regulation of histone acetylationGO:03506710.3MECP2, SNCA
4regulation of excitatory postsynaptic membrane potentialGO:06007910.3HCRT, SNCA, MECP2
5positive regulation of receptor recyclingGO:00192110.3SNCA, ECE1
6regulation of respiratory gaseous exchange by neurological system processGO:00208710.3MECP2, PHOX2B
7sphingolipid metabolic processGO:00666510.1GLA, ARSH, HEXB
8angiotensin maturationGO:00200310.1REN, MME
9proteolysisGO:00650810.1PHEX, ECE1, REN, MME, MMEL1
10neuropeptide signaling pathwayGO:0072189.8HCRT, GAL, NPY

Molecular functions related to Autonomic Dysfunction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.1MMEL1, MME, ECE1, PHEX

Products for genes affiliated with Autonomic Dysfunction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autonomic Dysfunction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet