MCID: ATN005
MIFTS: 49

Autonomic Dysfunction malady

Categories: Neuronal diseases

Aliases & Classifications for Autonomic Dysfunction

Aliases & Descriptions for Autonomic Dysfunction:

Name: Autonomic Dysfunction 51
Autonomic Nervous System Disorders 69
Autonomic Disorder 52

Classifications:



Summaries for Autonomic Dysfunction

NINDS : 51 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function that generally involves failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive or overactive ANS actions also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards based summary : Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to multiple system atrophy and hirschsprung disease, cardiac defects, and autonomic dysfunction, and has symptoms including back pain, constipation and diarrhea. An important gene associated with Autonomic Dysfunction is ECE1 (Endothelin Converting Enzyme 1), and among its related pathways/superpathways are Neuroscience and Parkinsons Disease Pathway. The drugs Dopamine and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 71 Dysautonomia is a term for a group of diseases that include postural orthostatic tachycardia syndrome... more...

Related Diseases for Autonomic Dysfunction

Diseases related to Autonomic Dysfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
id Related Disease Score Top Affiliating Genes
1 multiple system atrophy 30.0 SNCA UCHL1
2 hirschsprung disease, cardiac defects, and autonomic dysfunction 12.3
3 pitt-hopkins syndrome 11.2
4 neuroleptic malignant syndrome 11.0
5 neuropathy, hereditary sensory and autonomic, type ia 10.7
6 opsoclonus-myoclonus syndrome 10.7
7 neuropathy, hereditary sensory and autonomic, type ii 10.7
8 neuropathy, hereditary sensory and autonomic, type ic 10.7
9 riboflavin transporter deficiency 10.7
10 parkinson disease 5 10.7
11 parkinson disease 4 10.7
12 neuropathy, hereditary sensory and autonomic, type v 10.7
13 neuropathy, hereditary sensory and autonomic, type iib 10.7
14 paroxysmal extreme pain disorder 10.7
15 dysautonomia, familial 10.7
16 familial spastic paralysis 10.1 DBH SNCA
17 pythiosis 10.1 DBH SNCA
18 trichothiodystrophy 3, photosensitive 10.1 SNCA UCHL1
19 nephrogenic adenoma of the urethra 10.1 DBH SNCA
20 autism 19 10.1 DBH SNCA
21 deafness, autosomal recessive 102 10.0 SCN9A WNK1
22 obesity 10.0
23 plekhm1-related autosomal recessive osteopetrosis 10.0 SNCA UCHL1
24 dementia 9.9
25 mucolipidosis iv 9.9 SPTLC1 SPTLC2
26 neuropathy 9.9
27 hypertension, essential 9.9 DBH ECE1 WNK1
28 chagas disease 9.9
29 orthostatic intolerance 9.9
30 liver disease 9.9
31 sleep apnea 9.9
32 polycystic ovary syndrome 9.8
33 obstructive sleep apnea 9.8
34 dysautonomia 9.8
35 spinal cord injury 9.8
36 cerebritis 9.8
37 arthritis 9.8
38 epilepsy 9.8
39 polyneuropathy 9.8
40 ataxia 9.8
41 fissured tongue 9.8 SPTLC1 WNK1
42 auriculocondylar syndrome 1 9.8 SCN9A SPTLC1 SPTLC2
43 sleep disorder 9.8
44 postural orthostatic tachycardia syndrome 9.8
45 brain injury 9.8
46 rheumatoid arthritis 9.8
47 machado-joseph disease 9.8
48 myocardial infarction 9.8
49 tetanus 9.8
50 primary biliary cirrhosis 9.7

Graphical network of the top 20 diseases related to Autonomic Dysfunction:



Diseases related to Autonomic Dysfunction

Symptoms & Phenotypes for Autonomic Dysfunction

UMLS symptoms related to Autonomic Dysfunction:


back pain, constipation, diarrhea, headache, mydriasis, pain, rectal pain, sciatica, seizures, syncope, tremor, vomiting, chronic pain, lightheadedness, rectal tenesmus, warm skin, dry throat, palpitations - fluttering, pounding heart, syncope, effort, hyperemesis, anal pain, vomiting in newborn, blackout - symptom, vertigo/dizziness, increased sweating, vomiting alone, sleeplessness

MGI Mouse Phenotypes related to Autonomic Dysfunction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.87 WNK1 ECE1 SCN9A SNCA SPTLC2 UCHL1
2 homeostasis/metabolism MP:0005376 9.8 DBH WNK1 ECE1 SNCA SPTLC1 SPTLC2
3 integument MP:0010771 9.63 ECE1 SCN9A SNCA SPTLC2 UCHL1 DBH
4 mortality/aging MP:0010768 9.56 ECE1 SCN9A SNCA SPTLC1 SPTLC2 UCHL1
5 nervous system MP:0003631 9.17 WNK1 ECE1 SCN9A SNCA SPTLC1 UCHL1

Drugs & Therapeutics for Autonomic Dysfunction

Drugs for Autonomic Dysfunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 706)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
3
Zinc Approved Phase 4,Phase 2 7440-66-6 32051 23994
4
Candesartan Approved Phase 4,Phase 2 139481-59-7 2541
5
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
6
Carvedilol Approved, Investigational Phase 4,Phase 2,Phase 1 72956-09-3 2585
7
Bisoprolol Approved Phase 4 66722-44-9 2405
8
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 37350-58-6, 51384-51-1 4171
9
Felodipine Approved, Investigational Phase 4 72509-76-3 3333
10
Diltiazem Approved Phase 4,Phase 1 42399-41-7 39186
11
Nebivolol Approved, Investigational Phase 4,Phase 3,Phase 1 152520-56-4, 99200-09-6, 118457-14-0 71301
12
Acetylcholine Approved Phase 4,Phase 1,Phase 2 51-84-3 187
13
Propranolol Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 525-66-6 4946
14
Adenosine Approved, Investigational Phase 4,Phase 1 58-61-7 60961
15
Risperidone Approved, Investigational Phase 4,Phase 2 106266-06-2 5073
16
Fluoxetine Approved, Vet_approved Phase 4,Phase 2,Early Phase 1 54910-89-3 3386
17
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
18
Budesonide Approved Phase 4,Phase 3,Phase 2 51333-22-3 63006 5281004
19
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
20
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59729-33-8 2771
21 Zotepine Approved Phase 4 26615-21-4
22
Zolpidem Approved Phase 4 82626-48-0 5732
23
Benzocaine Approved Phase 4,Phase 2,Phase 3 1994-09-7, 94-09-7 2337
24
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
25
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
26
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-41-2 439260
27
Clonidine Approved Phase 4,Phase 2,Phase 1 4205-90-7 2803
28
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-02-2 5743
29
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
30
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-92-7 6047
31
Cyclosporine Approved, Investigational, Vet_approved Phase 4 79217-60-0, 59865-13-3 5284373 6435893
32
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
33
Aspirin Approved, Vet_approved Phase 4,Phase 1 50-78-2 2244
34
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
35
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2 24280-93-1 446541
36
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2 128794-94-5 5281078
37
Morphine Approved, Investigational Phase 4 57-27-2 5288826
38
Ibuprofen Approved Phase 4,Phase 1 15687-27-1 3672
39
Enalapril Approved, Vet_approved Phase 4,Phase 2 75847-73-3 5362032 40466924
40
Captopril Approved Phase 4,Phase 1 62571-86-2 44093
41
Lisinopril Approved, Investigational Phase 4,Phase 2,Phase 1 83915-83-7 5362119
42
Ramipril Approved Phase 4 87333-19-5 5362129
43
Enalaprilat Approved Phase 4,Phase 2 76420-72-9 6917719
44
Trandolapril Approved Phase 4 87679-37-6 5484727
45
Spironolactone Approved Phase 4,Phase 2,Phase 3 1952-01-7, 52-01-7 5833
46
Valsartan Approved, Investigational Phase 4,Phase 1 137862-53-4 60846
47
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2,Phase 1 58-93-5 3639
48
Atenolol Approved Phase 4,Phase 3,Phase 1,Phase 2 29122-68-7 2249
49
Eplerenone Approved Phase 4,Phase 1 107724-20-9 150310 443872
50
Doxazosin Approved Phase 4 74191-85-8 3157

Interventional clinical trials:

(show top 50) (show all 881)
id Name Status NCT ID Phase
1 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4
2 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4
3 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4
4 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
5 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4
6 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4
7 The Impact of the French PNNS Guidelines on Vascular Function Following a Standardised Breakfast. Unknown status NCT01579409 Phase 4
8 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4
9 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4
10 Combined Antihypertensive Therapy and Sexual Dysfunction Unknown status NCT01238705 Phase 4
11 Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement Unknown status NCT01717209 Phase 4
12 Onset of Action of Advair Hydrofluoroalkane (HFA) 115/21 in Comparison to Symbicort Pressurised Metered-Dose Inhalers (pMDI) 160/4.5 Measured by Impulse Oscillometry (IOS) Unknown status NCT00867737 Phase 4
13 Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation Unknown status NCT01162902 Phase 4
14 Coreg CR, Blood Vessel Stiffness and Blood Vessel Function Unknown status NCT00732511 Phase 4
15 The Preventive Effect of Escitalopram on Depression and Related Emotional Disorders in Acute Stroke Patients Unknown status NCT01278498 Phase 4
16 Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease Completed NCT00914134 Phase 4
17 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
18 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4
19 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4
20 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778 Phase 4
21 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4
22 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4
23 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4
24 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4
25 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4
26 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4
27 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4
28 Evaluation of the Autonomic Nervous System During First-dosing With 0.5mg of Fingolimod (Gilenya) in Patients With Relapsing-remitting MS Completed NCT02048072 Phase 4
29 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
30 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4
31 Restore Claims Characterization Study Completed NCT00200122 Phase 4
32 Early Intervention for Erectile Dysfunction After Laparoscopic Resection for Rectal Cancer Completed NCT01912586 Phase 4
33 Effects of Salmeterol on Autonomic Nervous System Completed NCT01536587 Phase 4
34 Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction Completed NCT01332812 Phase 4
35 Efficacy of 0.05 % Cyclosporine Ophthalmic Emulsion Compare With Tear in Meibomian Gland Dysfunction Completed NCT00705510 Phase 4
36 Irbesartan Effects on Endothelial Dysfunction in Hypertensive Type II Diabetic Patients Comparing Atenolol Completed NCT00549133 Phase 4
37 Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone Completed NCT00391846 Phase 4
38 A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder Completed NCT00195845 Phase 4
39 Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine Completed NCT00975325 Phase 4
40 Effects of Particle Size in Small Airways Dysfunction Completed NCT01892787 Phase 4
41 The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension Completed NCT01049009 Phase 4
42 Aging Brain Changes, Executive Dysfunction and Depression Completed NCT00918684 Phase 4
43 Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder Completed NCT00741598 Phase 4
44 A Study of Serial Magnetic Resonance Cholangiopancreatography (MRCP) Following Morphine-neostigmine and Secretin Provocation in Healthy Volunteers Completed NCT01134848 Phase 4
45 Opioid Effects on Swallowing and Esophageal Sphincter Pressure Completed NCT01191645 Phase 4
46 Elder Surgery - Functional Recovery Following Beta Blockade Completed NCT00507663 Phase 4
47 Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension Completed NCT00529750 Phase 4
48 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients Completed NCT03116269 Phase 4
49 Intraoperative Noradrenaline to Control Arterial Pressure (INPRESS Study) Completed NCT01536470 Phase 4
50 Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis Completed NCT00108355 Phase 4

Search NIH Clinical Center for Autonomic Dysfunction

Genetic Tests for Autonomic Dysfunction

Anatomical Context for Autonomic Dysfunction

MalaCards organs/tissues related to Autonomic Dysfunction:

39
Heart, Spinal Cord, Brain, Testes, Liver, Skin, Ovary

Publications for Autonomic Dysfunction

Articles related to Autonomic Dysfunction:

(show top 50) (show all 648)
id Title Authors Year
1
Cardiovascular Autonomic Dysfunction in Children and Adolescents With Rett Syndrome. ( 28351539 )
2017
2
Dante Alighieri: evidence for sleep disorder-related cardiac autonomic dysfunctions. ( 28000594 )
2017
3
Cardiovascular autonomic dysfunction in women with polycystic ovary syndrome: a systematic review and meta-analysis. ( 28483340 )
2017
4
Overactive bladder and autonomic dysfunction: Lower urinary tract symptoms in females with postural tachycardia syndrome. ( 26859225 )
2017
5
Heart Rate Variability for Quantification of Autonomic Dysfunction in Fibromyalgia. ( 27152281 )
2016
6
Orthostatic intolerance and autonomic dysfunction following bariatric surgery: A retrospective study and review of the literature. ( 27292926 )
2016
7
Autonomic dysfunction in first ever ischemic stroke: Prevalence, predictors and short term neurovascular outcome. ( 27588371 )
2016
8
OS 29-02 CIRCADIAN BLOOD PRESSURE PROFILE ABNORMALITIES AND AUTONOMIC DYSFUNCTION. ( 27643080 )
2016
9
Unusual phenotype of pathologically confirmed progressive supranuclear palsy with autonomic dysfunction and cerebellar ataxia: Case report. ( 27861346 )
2016
10
Autonomic Dysfunction: A Predictive Factor of Risk to Develop Rheumatoid Arthritis? ( 27211540 )
2016
11
Juvenile fibromyalgia syndrome: Blunted heart rate response and cardiac autonomic dysfunction at diagnosis. ( 27542737 )
2016
12
A Practical Approach to Autonomic Dysfunction in Patients with Headache. ( 27021770 )
2016
13
ANESTHETIC MANAGEMENT OF FEMORAL FRACTURE REPAIR IN A PATIENT WITH CERVICAL MYELOPATHY, AUTONOMIC DYSFUNCTION, AND DIFFICULT AIRWAY. ( 27382821 )
2016
14
Evaluation of Autonomic Dysfunction in Obese and Non-Obese Hypertensive Subjects. ( 27504394 )
2016
15
The role of autonomic dysfunction in cirrhotic patients before and after liver transplantation. Review of the literature. ( 27003923 )
2016
16
Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome. ( 27226447 )
2016
17
Changes in oral cavity during period of intensive vomiting in patient with somatoform autonomic dysfunction - description of the case. ( 27556111 )
2016
18
Lead toxicity promotes autonomic dysfunction with increased chemoreceptor sensitivity. ( 27133440 )
2016
19
Cardiovascular Autonomic Dysfunction Predicts Diabetic Foot Ulcers in Patients With Type 2 Diabetes Without Diabetic Polyneuropathy. ( 27015188 )
2016
20
Autonomic dysfunction in chronic kidney disease: An old problem in a new era. ( 27375046 )
2016
21
The autonomic dysfunction in patients with lupus disease: An electrophysiological study. ( 27376041 )
2016
22
Autonomic Dysfunction Precedes Development of Rheumatoid Arthritis: A Prospective Cohort Study. ( 27211565 )
2016
23
Study on autonomic dysfunction and metabolic syndrome in Chinese patients. ( 27181217 )
2016
24
Autonomic Dysfunction in Critical Illness: ObNOX(2)ious (Baro)reflex Upregulation of G Protein-Coupled Receptor Kinase-2 Lets the Heart Down. ( 27428129 )
2016
25
Distinctive cardiac autonomic dysfunction following stress exposure in both sexes in an animal model of PTSD. ( 27105958 )
2016
26
Prevalence of Autonomic Dysfunction in Hospitalized Patients with Guillain- Barre Syndrome. ( 28039863 )
2016
27
Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson's Disease. ( 27020456 )
2016
28
Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability. ( 27057817 )
2016
29
Cardiovagal and adrenergic function tests in unilateral carotid artery stenosis patients-a Valsalva manoeuvre tool to show an autonomic dysfunction? ( 26980215 )
2016
30
Comparison of heart rate variability and classic autonomic testing for detection of cardiac autonomic dysfunction in patients with fibromyalgia. ( 27126923 )
2016
31
Autonomic dysfunction in primary sleep disorders. ( 27198946 )
2016
32
Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. ( 26950003 )
2016
33
Pupillary Light Reflexes are Associated with Autonomic Dysfunction in Bolivian Diabetics But Not Chagas Disease Patients. ( 27044564 )
2016
34
Autonomic dysfunction in primary Sjogren's syndrome: a prospective cohort analysis of 154 Korean patients. ( 27017389 )
2016
35
Inflammatory markers are associated with cardiac autonomic dysfunction in recent-onset type 2 diabetes. ( 27481890 )
2016
36
Is there an association between markers of cardiovascular autonomic dysfunction at discharge from rehabilitation and participation one and five years later in individuals with spinal cord injury? ( 27084265 )
2016
37
Human papillomavirus vaccines, complex regional pain syndrome, postural orthostatic tachycardia syndrome, and autonomic dysfunction - a review of the regulatory evidence from the European Medicines Agency. ( 27867145 )
2016
38
Autonomic dysfunction in patients with essential tremor. ( 27812758 )
2016
39
Multiscale entropic assessment of autonomic dysfunction in patients with obstructive sleep apnea and therapeutic impact of continuous positive airway pressure treatment. ( 27318220 )
2016
40
Autonomic Dysfunction: How to Identify and When to Treat? ( 27342243 )
2016
41
Autonomic dysfunction in multiple sclerosis is better detected by heart rate variability and is not correlated with central autonomic network damage. ( 27423576 )
2016
42
The Association between Central Adiposity and Autonomic Dysfunction in Obesity. ( 27194294 )
2016
43
Cardiac stunning as first manifestation of multiple sclerosis: A case report reminding us not to overlook cardiovascular autonomic dysfunction in multiple sclerosis. ( 26993119 )
2016
44
Measures of Autonomic Dysfunction in Diabetic and Idiopathic Gastroparesis. ( 27785328 )
2016
45
Heart Rate Spectra Confirm the Presence of Autonomic Dysfunction in Dementia Patients. ( 27567816 )
2016
46
Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey. ( 25724570 )
2015
47
Autonomic Dysfunction in Patients with Mild to Moderate Alzheimer's Disease. ( 26401703 )
2015
48
Autonomic dysfunction syndromes after acute brain injury. ( 25701906 )
2015
49
Cardiovascular Autonomic Dysfunction in Patients with Morbid Obesity. ( 26536979 )
2015
50
Autonomic Dysfunction and Takotsubo Cardiomyopathy. ( 26500214 )
2015

Variations for Autonomic Dysfunction

Expression for Autonomic Dysfunction

Search GEO for disease gene expression data for Autonomic Dysfunction.

Pathways for Autonomic Dysfunction

Pathways related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.43 DBH SCN9A SNCA UCHL1
2 11.08 SNCA UCHL1
3 10.46 SNCA UCHL1

GO Terms for Autonomic Dysfunction

Cellular components related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.56 DBH ECE1 SCN9A SNCA SPTLC1 SPTLC2
2 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sensory perception of pain GO:0019233 9.48 SCN9A UCHL1
2 sphingolipid biosynthetic process GO:0030148 9.46 SPTLC1 SPTLC2
3 biosynthetic process GO:0009058 9.43 SPTLC1 SPTLC2
4 sphingolipid metabolic process GO:0006665 9.4 SPTLC1 SPTLC2
5 ceramide biosynthetic process GO:0046513 9.37 SPTLC1 SPTLC2
6 positive regulation of receptor recycling GO:0001921 9.32 ECE1 SNCA
7 sphingosine biosynthetic process GO:0046512 9.26 SPTLC1 SPTLC2
8 sphingomyelin biosynthetic process GO:0006686 9.16 SPTLC1 SPTLC2
9 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
10 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 9.16 DBH SNCA
2 pyridoxal phosphate binding GO:0030170 8.96 SPTLC1 SPTLC2
3 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Autonomic Dysfunction

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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