Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 14
Autonomic Nervous System Disorders 40 69
Abnormality of the Autonomic Nervous System 28
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 72

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 34 337.1
ICD10 32 G90 G90.8 G99.1

Summaries for Autonomic Nervous System Disease

MedlinePlus : 40 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to central hypoventilation syndrome, congenital and algoneurodystrophy, and has symptoms including sleeplessness, vomiting alone and increased sweating. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Benzocaine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain, and related phenotypes are behavior/neurological and normal

Wikipedia : 72 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 central hypoventilation syndrome, congenital 31.2 ASCL1 EDNRB PHOX2A PHOX2B
2 algoneurodystrophy 30.0 CALCA NGF
3 reflex sympathetic dystrophy 30.0 CALCA CHSY1 NPS
4 burns 30.0 ALB INS TTR
5 burning mouth syndrome 29.8 NGF TAC1
6 parkinson disease, late-onset 29.1 DBH DRD4 NGF TAC1
7 migraine with or without aura 1 28.5 CALCA DBH DRD4 EDNRB NPS TAC1
8 autonomic dysfunction 11.2
9 autonomic peripheral neuropathy 11.2
10 pancreatic islet cell tumors 10.4 CALCA INS
11 duodenal somatostatinoma 10.4 CALCA INS
12 burn scar 10.4 CALCA TAC1
13 retinitis pigmentosa 68 10.4 NPS TAC1
14 paramyloidosis 10.4 ALB TTR
15 epicondylitis 10.4 NPS TAC1
16 vasomotor rhinitis 10.4 CALCA TAC1
17 urticaria pigmentosa 10.3 CALCA TAC1
18 marasmus 10.3 ALB TTR
19 somatostatinoma 10.3 CALCA INS
20 kwashiorkor 10.3 ALB TTR
21 bladder neck obstruction 10.3 TAC1 TTR
22 neuroschistosomiasis 10.3 NGF TAC1
23 bullous impetigo 10.3 CALCA EDNRB
24 decubitus ulcer 10.3 ALB TTR
25 prurigo nodularis 10.3 NGF TAC1
26 aleutian mink disease 10.3 ALB TTR
27 exotropia 10.3 PHOX2A PHOX2B
28 aspiration pneumonia 10.2 ALB TAC1
29 chronic ulcer of skin 10.2 ALB TTR
30 impetigo 10.2 CALCA EDNRB
31 postural hypotension 10.2 DBH INS
32 prolactin producing pituitary tumor 10.2 CALCA NGF
33 dental pulp disease 10.2 NPS TAC1
34 colonic disease 10.2 ASCL1 EDNRB PHOX2B
35 hyperthyroxinemia 10.2 ALB TTR
36 amyloid tumor 10.2 CALCA TTR
37 early-onset schizophrenia 10.1 DBH DRD4 INS
38 fascioliasis 10.1 ALB INS
39 amyloidosis, hereditary, transthyretin-related 10.1 DBH TTR
40 hypoglycemic coma 10.1 HBA2 INS
41 gastrointestinal system disease 10.1 ALB EDNRB INS
42 type 1 diabetes mellitus 7 10.1 HBA2 INS
43 type 1 diabetes mellitus 11 10.1 HBA2 INS
44 intestinal disease 10.0 ALB EDNRB TAC1
45 multiple endocrine neoplasia, type iib 10.0 CALCA EDNRB
46 autonomic neuropathy 10.0 ALB INS NGF
47 fetal erythroblastosis 10.0 ALB INS
48 demyelinating polyneuropathy 10.0 ALB NGF TTR
49 goldberg-shprintzen syndrome 10.0 ASCL1 EDNRB NGF
50 hirschsprung disease 1 10.0 ASCL1 EDNRB PHOX2B TAC1

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Parkinson Disease, Late-Onset
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


sleeplessness, vomiting alone, increased sweating, vertigo/dizziness, blackout - symptom, vomiting in newborn, anal pain, hyperemesis, syncope, effort, pounding heart, palpitations - fluttering, dry throat, warm skin, rectal tenesmus, decrease in appetite, lightheadedness, chronic pain, vomiting, tremor, syncope, seizures, sciatica, rectal pain, pain, mydriasis, headache, diarrhea, constipation, back pain

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ASCL1 CHSY1 DBH DRD4 EDNRB INS
2 normal MP:0002873 9.5 ALB ASCL1 DBH INS NGF PHOX2B
3 vision/eye MP:0005391 9.28 ASCL1 CHSY1 DBH DRD4 EDNRB INS

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 495)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3 1994-09-7, 94-09-7 2337
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Zolpidem Approved Phase 4 82626-48-0 5732
5 Zotepine Approved, Investigational Phase 4 26615-21-4
6
Acetylcholine Approved Phase 4 51-84-3 187
7
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
8
Midodrine Approved Phase 4,Phase 3,Phase 2,Phase 1 42794-76-3, 133163-28-7 4195
9
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 1 51384-51-1, 37350-58-6 4171
10
Bupivacaine Approved, Investigational Phase 4,Phase 3 38396-39-3, 2180-92-9 2474
11
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
12
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-92-7 6047
13
Propranolol Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 525-66-6 4946
14
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 1
15
Fludrocortisone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 127-31-1 31378
16
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
17
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
18
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23651-95-8 443940
19
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
20
Bisoprolol Approved Phase 4 66722-44-9 2405
21 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3
22
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1 50-81-7 54670067 5785
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
24 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
25 Dopamine agonists Phase 4,Phase 1
26 N 0437 Phase 4
27 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antipsychotic Agents Phase 4,Phase 3
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Dopamine Antagonists Phase 4,Phase 3,Phase 1
31 GABA Agents Phase 4,Early Phase 1
32 GABA Agonists Phase 4
33 GABA-A Receptor Agonists Phase 4
34 Hypnotics and Sedatives Phase 4,Phase 1,Early Phase 1
35 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36
Serotonin Phase 4,Phase 2,Phase 1,Early Phase 1 50-67-9 5202
37 Serotonin Agents Phase 4,Phase 2,Phase 1,Early Phase 1
38 Serotonin Antagonists Phase 4
39 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 abobotulinumtoxinA Phase 4
41 Botulinum Toxins Phase 4
42 Botulinum Toxins, Type A Phase 4
43 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
44 Neuromuscular Agents Phase 4
45 onabotulinumtoxinA Phase 4
46 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
47 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1
48 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Adrenergic Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1
50 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 509)

# Name Status NCT ID Phase Drugs
1 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4 Rotigotine;Placebo patchs
2 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4 Risperidone and Zolpidem for delirium
3 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
4 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
5 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
6 Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease Completed NCT00914134 Phase 4 Levodopa infusion
7 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
8 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
9 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
10 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
11 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
12 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4 Midodrine;Pyridostigmine Bromide;Midodrine + pyridostigmine
13 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4 Midodrine HCl;Placebo
14 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4 Midodrine HCl;Placebo
15 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
16 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
17 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4 fludrocortisone acetate
18 Restore Claims Characterization Study Completed NCT00200122 Phase 4
19 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
20 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
21 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
22 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Recruiting NCT03178591 Phase 4 vildagliptin;Dapagliflozin
23 Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Recruiting NCT03350659 Phase 4 Midodrine;Atomoxetine
24 Dawn Simulation and Postural Hypotension Recruiting NCT02632318 Phase 4
25 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
26 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Recruiting NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
27 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Active, not recruiting NCT03098368 Phase 4 Rotigotine;Placebo
28 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
29 Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) Active, not recruiting NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
30 Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Not yet recruiting NCT03229174 Phase 4 Droxidopa;Placebo
31 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Not yet recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
32 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
33 A Study Evaluating Hypotension and Autonomic Nervous System Dysfunction in Multiple Myeloma (MM) Patients Unknown status NCT01314625 Phase 3
34 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
35 Post-Exercise Hypotension in Elderly Hypertensive Men Unknown status NCT02415582 Phase 3
36 Clinical Trial on the Effectiveness of Traditional Chinese Medicinal Mixture in Parkinson Disease Unknown status NCT00629161 Phase 2, Phase 3 Traditional Chinese Medicinal Mixture (composed of Roucongrong and adjuvant);placebo
37 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
38 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
39 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
40 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
41 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
42 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
43 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo
44 The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury Completed NCT02099890 Phase 3
45 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Completed NCT01132326 Phase 3 Droxidopa
46 A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Completed NCT00782340 Phase 3 Placebo;Droxidopa
47 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
48 Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Completed NCT01522235 Phase 2, Phase 3 Double blinded IVIg
49 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
50 Clinical Trial on the Effectiveness of Herbal Medicinal Mixture in Parkinson Disease Completed NCT00656253 Phase 2, Phase 3 Herbal Medicinal Mixture (Roucongrong, Heshouwu etc.);Placebo

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 28

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

38
Heart, Spinal Cord, Brain, Testes, Liver, Bone, Cortex

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

# Title Authors Year
1
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. ( 23771848 )
2013
2
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. ( 23110271 )
2012
3
Autonomic nervous system disorders and reflex sympathetic dystrophy in lightning and electrical injuries. ( 8848658 )
1995

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh38 Chromosome 11, 637539: 637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

Pathways for Autonomic Nervous System Disease

Pathways related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 ALB ASCL1 INS
2 11.23 ASCL1 NGF PHOX2A PHOX2B TAC1
3 10.78 ALB INS TTR

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CALCA DBH HBA2 INS TAC1
2 extracellular region GO:0005576 9.32 ALB CALCA CHSY1 DBH HBA2 INS

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.94 CALCA INS NGF TTR
2 cell-cell signaling GO:0007267 9.84 CALCA INS NGF TAC1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.78 CALCA EDNRB TAC1
4 cellular protein metabolic process GO:0044267 9.73 ALB CALCA INS TTR
5 neuropeptide signaling pathway GO:0007218 9.72 CALCA NPS TAC1
6 response to amphetamine GO:0001975 9.63 DBH DRD4
7 associative learning GO:0008306 9.63 DBH TAC1
8 regulation of blood pressure GO:0008217 9.63 CALCA EDNRB TAC1
9 positive regulation of blood vessel diameter GO:0097755 9.62 CALCA INS
10 dopaminergic neuron differentiation GO:0071542 9.62 PHOX2A PHOX2B
11 vasodilation GO:0042311 9.61 CALCA EDNRB
12 negative regulation of ossification GO:0030279 9.6 CALCA CHSY1
13 glial cell differentiation GO:0010001 9.59 ASCL1 PHOX2B
14 negative regulation of protein secretion GO:0050709 9.58 DRD4 INS
15 positive regulation of ossification GO:0045778 9.57 CALCA TAC1
16 behavioral response to ethanol GO:0048149 9.56 DBH DRD4
17 positive regulation of renal sodium excretion GO:0035815 9.52 EDNRB TAC1
18 positive regulation of synaptic transmission, GABAergic GO:0032230 9.51 NPS TAC1
19 enteric nervous system development GO:0048484 9.49 EDNRB PHOX2B
20 sympathetic ganglion development GO:0061549 9.48 ASCL1 PHOX2B
21 positive regulation of action potential GO:0045760 9.4 NPS TAC1
22 noradrenergic neuron differentiation GO:0003357 9.37 PHOX2A PHOX2B
23 fear response GO:0042596 9.32 DBH DRD4
24 noradrenergic neuron development GO:0003358 9.26 ASCL1 PHOX2B
25 parasympathetic nervous system development GO:0048486 9.16 PHOX2A PHOX2B
26 sympathetic nervous system development GO:0048485 9.13 ASCL1 PHOX2A PHOX2B
27 response to pain GO:0048265 8.92 CALCA DBH EDNRB TAC1
28 G-protein coupled receptor signaling pathway GO:0007186 10.05 CALCA DRD4 EDNRB INS NPS TAC1

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA INS TTR

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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