MCID: ATN002
MIFTS: 48

Autonomic Nervous System Disease

Categories: Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 14
Autonomic Nervous System Disorders 41 69
Abnormality of the Autonomic Nervous System 29
Autonomic Nervous System Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 35 337.1
ICD10 33 G90 G90.8 G99.1
UMLS 69 C0154691

Summaries for Autonomic Nervous System Disease

MedlinePlus : 41 your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. when something goes wrong in this system, it can cause serious problems, including blood pressure problems heart problems trouble with breathing and swallowing erectile dysfunction in men autonomic nervous system disorders can occur alone or as the result of another disease, such as parkinson's disease, alcoholism and diabetes. problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. some types are temporary, but many worsen over time. when they affect your breathing or heart function, these disorders can be life-threatening. some autonomic nervous system disorders get better when an underlying disease is treated. often, however, there is no cure. in that case, the goal of treatment is to improve symptoms. nih: national institute of neurological disorders and stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to central hypoventilation syndrome, congenital and pandas, and has symptoms including back pain, constipation and diarrhea. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Benzocaine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and eye, and related phenotypes are behavior/neurological and normal

Related Diseases for Autonomic Nervous System Disease

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
id Related Disease Score Top Affiliating Genes
1 central hypoventilation syndrome, congenital 31.7 CALCA EDNRB
2 pandas 10.7 CALCA INS
3 cervical keratinizing squamous cell carcinoma 10.7 CALCA INS
4 cartilage disease 10.6 CALCA TAC1
5 mental retardation, autosomal recessive 54 10.6 NPS TAC1
6 spinal muscular atrophy 10.6 CALCA INS
7 boutonneuse fever 10.6 NPS TAC1
8 somatoform disorder 10.6 CALCA TAC1
9 midface dysplasia 10.5 ALB TTR
10 early-onset severe reducing body myopathy, x-linked 10.5 ALB TTR
11 isolated scaphocephaly 10.5 CALCA EDNRB
12 cough variant asthma 10.5 CALCA TAC1
13 malignant renovascular hypertension 10.5 NGF TAC1
14 uterine corpus epithelioid leiomyoma 10.5 TAC1 TTR
15 pseudoainhum 10.4 NGF TAC1
16 male genital organ stricture 10.4 ALB TTR
17 female infertility of uterine origin 10.4 ALB TTR
18 juvenile dermatitis herpetiformis 10.4 CALCA EDNRB
19 speech and communication disorders 10.4 ALB TTR
20 malignant visceral pleura tumor 10.4 CALCA NGF
21 vascular disease 10.4 ALB EDNRB
22 milker's nodule 10.4 ALB TTR
23 endometriosis of ovary 10.4 PHOX2A PHOX2B
24 lung lymphoma 10.4 CALCA TTR
25 wolffian duct adenocarcinoma 10.4 ASCL1 EDNRB PHOX2B
26 water-clear cell adenoma 10.4 CALCA NGF
27 repetitive stress injuries 10.4 DBH INS
28 motion sickness 10.4 ALB TTR
29 neuropathy, hereditary thermosensitive 10.3 CALCA CHSY1 NPS
30 cryptogenic organizing pneumonia 10.3 ALB TAC1
31 cataract 10.3 ALB INS TTR
32 epulis 10.3 NPS TAC1
33 hemoglobinopathy 10.2 ALB TTR
34 pauci-immune glomerulonephritis with anca 10.2 DBH DRD4 INS
35 angiomyolipoma 10.2 NPS TAC1
36 breast fibroadenoma 10.2 HBA2 INS
37 carpal tunnel syndrome, familial 10.2 DBH TTR
38 tuberculum sellae meningioma 10.2 ALB EDNRB INS
39 paroxysmal nonkinesigenic dyskinesia 2 10.2 HBA2 INS
40 tonsil cancer 10.2 ALB INS
41 tinea favosa 10.2 NGF TAC1
42 neuropathy, hereditary sensory and autonomic, type ic 10.1 HBA2 INS
43 endometrial clear cell adenocarcinoma 10.1 ALB EDNRB TAC1
44 shprintzen-goldberg syndrome 10.1 ASCL1 EDNRB NGF
45 myasthenic syndrome, congenital, 21, presynaptic 10.1 ASCL1 EDNRB PHOX2B TAC1
46 albinism, oculocutaneous, type v 10.1 CALCA DRD4 NPS TAC1
47 fissured tongue 10.1 ALB INS NGF
48 late yaws 10.0 ALB NGF TAC1
49 infertility 10.0 ALB NGF TTR
50 pancreatic acinar cell adenocarcinoma 10.0 INS NGF PHOX2B TTR

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Parkinson Disease, Late-Onset
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


back pain, constipation, diarrhea, headache, mydriasis, pain, rectal pain, sciatica, seizures, syncope, tremor, vomiting, chronic pain, lightheadedness, rectal tenesmus, warm skin, dry throat, palpitations - fluttering, pounding heart, syncope, effort, hyperemesis, anal pain, vomiting in newborn, blackout - symptom, vertigo/dizziness, increased sweating, vomiting alone, sleeplessness

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ASCL1 CHSY1 DBH DRD4 EDNRB INS
2 normal MP:0002873 9.5 ALB ASCL1 DBH INS NGF PHOX2B
3 vision/eye MP:0005391 9.28 CHSY1 DBH DRD4 EDNRB INS NGF

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1283)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Risperidone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 106266-06-2 5073
4
Zolpidem Approved Phase 4,Phase 3 82626-48-0 5732
5 Zotepine Approved Phase 4 26615-21-4
6
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
7
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 137-58-6 3676
8
Citalopram Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59729-33-8 2771
9
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
10
Galantamine Approved Phase 4,Phase 3,Phase 2,Phase 1 357-70-0 9651
11
Nicotine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54-11-5 942 89594
12 Beractant Approved Phase 4 108778-82-1
13
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51333-22-3 63006 5281004
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
16
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 54910-89-3 3386
17
Fluvoxamine Approved, Investigational Phase 4,Phase 3 54739-18-3 3404 5324346
18
Paroxetine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61869-08-7 43815
19
Sertraline Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 79617-96-2 68617
20
Carbidopa Approved Phase 4,Phase 3,Phase 2,Phase 1 28860-95-9 34359 38101
21
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-92-7 6047
22
Diazepam Approved, Illicit, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 439-14-5 3016
23
Bupropion Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 34841-39-9, 34911-55-2 444
24
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
25
Mianserin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 24219-97-4 4184
26
Mirtazapine Approved Phase 4,Phase 3,Phase 2,Early Phase 1 85650-52-8, 61337-67-5 4205
27
Norepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-41-2 439260
28
Trazodone Approved, Investigational Phase 4,Phase 3 19794-93-5 5533
29
Metoprolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 37350-58-6, 51384-51-1 4171
30
Terbutaline Approved Phase 4,Phase 3,Phase 2 23031-25-6 5403
31
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
32
Cilostazol Approved Phase 4,Phase 3,Phase 2,Phase 1 73963-72-1 2754
33
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
34
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
35
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
36
Ticlopidine Approved Phase 4 55142-85-3 5472
37
Carbamazepine Approved, Investigational Phase 4,Phase 3,Phase 2 298-46-4 2554
38
Coal tar Approved Phase 4,Phase 2 8007-45-2
39
Olanzapine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 132539-06-1 4585
40
Oxcarbazepine Approved Phase 4,Phase 3 28721-07-5 34312
41
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
42
Ziprasidone Approved Phase 4,Phase 3,Phase 2 146939-27-7 60854
43
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
44
Clonidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 4205-90-7 2803
45
Domperidone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 57808-66-9 3151
46
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 73590-58-6 4594
47
Reboxetine Approved, Investigational Phase 4,Phase 3 98769-81-4, 71620-89-8 123628 65856
48
Atenolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 29122-68-7 2249
49
Nicorandil Approved Phase 4 65141-46-0 47528
50
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 69-65-8 453 6251

Interventional clinical trials:

(show top 50) (show all 4247)

id Name Status NCT ID Phase Drugs
1 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4 Rotigotine;Placebo patchs
2 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4 Risperidone and Zolpidem for delirium
3 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
4 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
5 The Effects of Continuous Positive Airway Pressure on Overlap Syndrome Unknown status NCT00914264 Phase 4
6 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
7 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
8 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
9 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
10 Efficacy and Safety of Ursodeoxycholic Acid (UDCA) Added to the DPP-4 Inhibitor in People With Type 2 Diabetes and Chronic Liver Diseases Unknown status NCT01337440 Phase 4 UDCA;Sitagliptin
11 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
12 Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain Unknown status NCT00445133 Phase 4
13 The Impact of the French PNNS Guidelines on Vascular Function Following a Standardised Breakfast. Unknown status NCT01579409 Phase 4
14 Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain Unknown status NCT00444990 Phase 4
15 Neurophysiologic Changes in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
16 Diffusion Tensor Weighted MRI in Alzheimer's Disease Modifying Treatment Effects of Galantamine (Reminyl®) Unknown status NCT00523666 Phase 4 Galantamine (Reminyl®);Placebo/Galantamine (Reminyl®)
17 Nicotine Treatment of Impulsivity in Parkinson's Disease Unknown status NCT01216904 Phase 4 nicotine patch;placebo
18 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
19 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
20 Inhaler Lung Deposition in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT01721291 Phase 4 SALBUTAMOL
21 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
22 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
23 Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients Unknown status NCT01131806 Phase 4 fluticasone/ salmeterol 125/25 mcg/puff;fluticasone/ salmeterol 250/25 mcg/puff
24 Remission of ICD by Switching Dopamine Agonist to Levodopa/Carbidopa Unknown status NCT01683253 Phase 4 Levodopa/Carbidopa(200mg/50mg)
25 Prevention of Posttraumatic Stress Disorder (PTSD) With Diazepam Unknown status NCT01221883 Phase 4 Diazepam
26 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
27 Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT00288548 Phase 4 Metoprolol
28 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status NCT00120978 Phase 4 Advair;Flovent
29 Efficacy and Safety of Tulobuterol Patch Combined With Tiotropium Bromide for Relieving Dyspnea Symptom of Chronic Obstructive Pulmonary Disease Unknown status NCT01465906 Phase 4 tulobuterol;Tiotropium Bromide;tiotropium bromide
30 Treatment Youth With Obsessive-Compulsive Disorder Unknown status NCT00708240 Phase 4 Escitalopram
31 The Relationship Between Risperdal Treatment and Quality of Life in Patients With Alzheimer's Disease and Behavioural and Psychological Symptoms of Dementia (BPSD) Unknown status NCT00626613 Phase 4 Risperdal,reminyl
32 Medications for the Treatment of Dysthymic Disorder and Double Depression Unknown status NCT00234312 Phase 4 escitalopram and sertraline
33 Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
34 Study of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia, and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
35 Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients Unknown status NCT01780467 Phase 4
36 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4 Triple anti-platelet therapy (TAT);Double-dose clopidogrel anti-platelet therapy (DDAT)
37 Comparative Efficacy and Acceptability of Antimanic Drugs in Acute Mania Unknown status NCT01893229 Phase 4 Lithium;Valproate;Oxcarbazepine;Quetiapine;Olanzapine;Ziprasidone
38 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
39 Small Airways Evaluation and Treatment Unknown status NCT02526758 Phase 4 beclomethasone;formoterol;budesonide
40 Exhaled NO Based Treatment of Chronic Obstructive Pulmonary Disease (COPD), ICS/LABA Versus LAMA Unknown status NCT02546349 Phase 4 fluticasone/salmeterol, tiotropium
41 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
42 Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity Unknown status NCT02140073 Phase 4 omeprazole+domperidone SR;omeprazole
43 Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
44 Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma Unknown status NCT00500253 Phase 4
45 Study to Assess Efficacy of Nicorandil+Atenolol vs Atenolol in Treatment of Chronic Stable Angina. Unknown status NCT01397994 Phase 4 Nicorandil;Atenolol
46 Predictor for an Additional Benefit of Inhaled Corticosteroid in Patients Treated With Tiotropium for COPD Unknown status NCT00860938 Phase 4 Budesonide
47 The Efficacy and Safety of Salmeterol/Fluticasone Propionate vs Atropium/Albuterol in Patients COPD Unknown status NCT01243788 Phase 4 Salmeterol/Fluticasone Propionate
48 Deep Neuromuscular Blockade During Robotic Radical Prostatectomy Unknown status NCT02513693 Phase 4 Standard neuromuscular blockade;Deep neuromuscular blockade
49 The Effect of IV Amantadine on Freezing of Gait (FOG) Resistant to Dopaminergic Therapy Unknown status NCT01313819 Phase 4 PK-Merz® 200mg/500ml inj(Amantadine) , Normal saline 500ml inj
50 Comparison of Efficacy of Ivabradine Versus Metoprolol Unknown status NCT01755663 Phase 4 Ivabradine and Metoprolol

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 29

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

39
Heart, Lung, Eye, Brain, Spinal Cord, Testes, Kidney

Publications for Autonomic Nervous System Disease

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh38 Chromosome 11, 637539: 637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

Pathways for Autonomic Nervous System Disease

Pathways related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 ALB ASCL1 INS
2 11.23 ASCL1 NGF PHOX2A PHOX2B TAC1
3 10.78 ALB INS TTR

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CALCA DBH HBA2 INS TAC1
2 extracellular region GO:0005576 9.32 ALB CALCA CHSY1 DBH HBA2 INS

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.85 CALCA INS NGF TAC1
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.77 CALCA EDNRB TAC1
3 cellular protein metabolic process GO:0044267 9.73 ALB CALCA INS TTR
4 neuropeptide signaling pathway GO:0007218 9.71 CALCA NPS TAC1
5 regulation of blood pressure GO:0008217 9.63 CALCA EDNRB TAC1
6 associative learning GO:0008306 9.62 DBH TAC1
7 response to amphetamine GO:0001975 9.62 DBH DRD4
8 dopaminergic neuron differentiation GO:0071542 9.61 PHOX2A PHOX2B
9 vasodilation GO:0042311 9.61 CALCA EDNRB
10 negative regulation of ossification GO:0030279 9.59 CALCA CHSY1
11 glial cell differentiation GO:0010001 9.58 ASCL1 PHOX2B
12 negative regulation of protein secretion GO:0050709 9.58 DRD4 INS
13 behavioral response to ethanol GO:0048149 9.57 DBH DRD4
14 positive regulation of ossification GO:0045778 9.56 CALCA TAC1
15 positive regulation of renal sodium excretion GO:0035815 9.52 EDNRB TAC1
16 positive regulation of synaptic transmission, GABAergic GO:0032230 9.51 NPS TAC1
17 enteric nervous system development GO:0048484 9.49 EDNRB PHOX2B
18 sympathetic ganglion development GO:0061549 9.48 ASCL1 PHOX2B
19 positive regulation of action potential GO:0045760 9.4 NPS TAC1
20 noradrenergic neuron differentiation GO:0003357 9.37 PHOX2A PHOX2B
21 fear response GO:0042596 9.32 DBH DRD4
22 noradrenergic neuron development GO:0003358 9.26 ASCL1 PHOX2B
23 parasympathetic nervous system development GO:0048486 9.16 PHOX2A PHOX2B
24 sympathetic nervous system development GO:0048485 9.13 ASCL1 PHOX2A PHOX2B
25 response to pain GO:0048265 8.92 CALCA DBH EDNRB TAC1

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.35 ALB CALCA DRD4 INS TTR
2 hormone activity GO:0005179 8.8 CALCA INS TTR

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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