MCID: ATN004
MIFTS: 54

Autonomic Neuropathy malady

Neuronal diseases category

Summaries for Autonomic Neuropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Dysautonomia (or autonomic dysfunction) is any disease or malfunction of the autonomic nervous system... more...

MalaCards: Autonomic Neuropathy is related to neuropathy and diabetic autonomic neuropathy. An important gene associated with Autonomic Neuropathy is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are TRKA activation by NGF and NGF-independant TRKA activation. The compounds ana 12 and bdnf (human) have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and skin, and related mouse phenotypes are muscle and vision/eye.

Aliases & Classifications for Autonomic Neuropathy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autonomic neuropathy 8 10 44 60


External Ids:

Disease Ontology8 DOID:11504
SNOMED-CT56 277879009
NCIt39 C27033

Related Diseases for Autonomic Neuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Autonomic Dysfunction family:

autonomic neuropathy

Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 192)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.1IKBKAP, INS, NGF, NTF3, AKR1B1
2diabetic autonomic neuropathy32.0NGF, MLNR, AKR1B1
3diabetic neuropathy32.0INS, NGF, NGFR, NTF3, NTRK1, AKR1B1
4hereditary sensory neuropathy31.3SPTLC2, SPTLC1, IKBKAP, NGF, NTRK1
5diabetes mellitus31.3CCK, GAD1, AKR1B1, MLN, NGF, INS
6peripheral neuropathy31.0NTRK1, WNK1, SPTLC1, SPTLC2
7type 2 diabetes mellitus30.8CCK, GAD1, AKR1B1, NGF, INS
8pancreatitis30.7INS, CCK
9hypoglycemia30.6INS, DBH, MLN, AKR1B1, GAST, GAD1
10anhidrosis30.5NGF, NGFR, NTRK1
11riley-day syndrome30.5NTRK1, DBH, IKBKAP
12hypertension30.5WNK1, INS, DBH
13polyneuropathy30.4AKR1B1
14obesity30.4CCK, AKR1B1, MLN, INS
15diabetic retinopathy30.4GAD1, AKR1B1, INS
16neuropathy hereditary sensory and autonomic type 130.4SPTLC2, SPTLC1
17esophagitis30.3GAST
18hepatitis30.3DBH
19diabetic polyneuropathy30.3AKR1B1, NTF3, NGF
20ischemia30.3GAD1, AKR1B1, MLN, NTRK1, NTF3, NGFR
21constipation30.1CCK, MLN
22prion disease30.1NGF, NTF3, NTRK1
23gastroparesis30.1CCK, GAST, MLNR, MLN, INS
24neuroaxonal dystrophy29.9NTRK1, NTF3, NGF
25diarrhea29.9INS, MLN, GAST
26motor neuron disease29.9NTF3
27neuroblastoma29.9NTRK1, DBH, NGFR, NGF
28dyspepsia29.9CCK, GAST, MLNR, MLN
29sensory peripheral neuropathy29.9AKR1B1, NTRK1, NTF3, NGF, SPTLC1
30pheochromocytoma29.9MLN, NTRK1, NTF3, DBH, NGFR, NGF
31hereditary sensory and autonomic neuropathy type ii10.7
32hereditary sensory and autonomic neuropathy iv10.7
33autonomic peripheral neuropathy10.7
34hereditary sensory and autonomic neuropathy type v10.5
35type 1 diabetes mellitus10.5
36dnmt1-related dementia, deafness, and sensory neuropathy10.5
37diabetic nephropathy10.4
38amyloidosis10.4
39hereditary sensory and autonomic neuropathy type vi10.4
40hereditary sensory and autonomic neuropathy type 1b10.4
41idiopathic peripheral autonomic neuropathy10.3
42atherosclerosis10.3
43coronary artery disease10.3
44cerebritis10.3
45x-linked hereditary sensory and autonomic neuropathy with deafness10.3
46axonal neuropathy10.2
47iritis10.2
48neuronitis10.2
49acute porphyria10.2
50myocardial infarction10.2

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to autonomic neuropathy

Clinical Features for Autonomic Neuropathy

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Drugs & Therapeutics for Autonomic Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Autonomic Neuropathy

Search NIH Clinical Center for Autonomic Neuropathy

Search CenterWatch for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

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Anatomical Context for Autonomic Neuropathy

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32MalaCards
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MalaCards organs/tissues related to Autonomic Neuropathy:

32
Heart, Testes, Skin, Liver, Colon, Kidney, B cells, Pancreas, Lung, Bone marrow, Spinal cord, Brain, Bone, Eye, Pancreatic islet, Adrenal gland

Animal Models for Autonomic Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Autonomic Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.8NTF3, NGFR, NGF, INS, WNK1, IKBKAP
2MP:00053919.8AKR1B1, NTRK1, NTF3, DBH, NGFR, NGF
3MP:00107719.5NTRK1, DBH, NGFR, NGF, EPO, INS
4MP:00053859.5NTF3, HCN3, DBH, NGFR, NGF, EPO
5MP:00053869.4GAD1, AKR1B1, NTRK1, NTF3, DBH, NGFR
6MP:00053789.4GAD1, AKR1B1, NTRK1, NTF3, DBH, NGFR
7MP:00028739.3GAD1, NTRK1, NTF3, DBH, NGFR, NGF
8MP:00036319.2CCK, GAD1, NTRK1, NTF3, HCN3, DBH
9MP:00053769.1DBH, NTF3, AKR1B1, GAST, GAD1, CCK
10MP:00107689.0SPTLC2, GAD1, GAST, AKR1B1, NTRK1, NTF3

Publications for Autonomic Neuropathy

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50PubMed
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Articles related to Autonomic Neuropathy:

(show top 50)    (show all 786)
idTitleAuthorsYear
1
Haemodynamic changes during a squat test, pulsatile stress and indices of cardiovascular autonomic neuropathy in patients with long-duration type 1 diabetes. (22030241)
2012
2
QTc-interval, heart rate variability and postural hypotension as an indicator of cardiac autonomic neuropathy in type 2 diabetic patients. (22755273)
2012
3
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. (21247746)
2011
4
The effect of diabetic autonomic neuropathy on P-wave duration, dispersion and atrial fibrillation. (22291825)
2011
5
Natural progression of cardiac autonomic neuropathy in patients with type 1 diabetes: a four-year follow-up study. (21466989)
2011
6
Clinical correlates of painful diabetic neuropathy and relationship of neuropathic pain with sensorimotor and autonomic nerve function. (20619708)
2011
7
Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. (22045570)
2011
8
Assessment of diabetic cardiac autonomic neuropathy in type I diabetic mice. (22255842)
2011
9
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. (21986117)
2011
10
Autonomic neuropathy in diabetes mellitus and obesity: an update. (22203830)
2011
11
Influenza A induced acute autonomic neuropathy in an adolescent. (21093734)
2010
12
Is cardiac autonomic neuropathy the basis of nonischemic diabetic cardiomyopathy? (21163449)
2010
13
Evaluation of peripheral and autonomic neuropathy among patients with newly diagnosed impaired glucose tolerance. (18636432)
2008
14
Stress ECG and laboratory database for the assessment of diabetic cardiovascular autonomic neuropathy. (18002963)
2007
15
Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis. (16832660)
2006
16
A case of hereditary sensory and autonomic neuropathy type II with plantar ulceration. (16836519)
2006
17
Hereditary sensory autonomic neuropathy Type IV. (15817982)
2005
18
Hereditary sensory neuropathy type 1 in a Portuguese family-electrodiagnostic and autonomic nervous system studies. (15546589)
2004
19
Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody. (14732619)
2004
20
Cardiovascular autonomic neuropathy associated with carotid atherosclerosis in Type 2 diabetic patients. (12786687)
2003
21
Diabetic autonomic neuropathy. (15088257)
2003
22
Repeated neostigmine dosage as palliative treatment for chronic colonic pseudo-obstruction in a patient with autonomic paraneoplastic neuropathy. (12650823)
2003
23
Experimental autoimmune autonomic neuropathy. (12773498)
2003
24
Congenital insensitivity to pain (hereditary sensory and autonomic neuropathy) HSAN: a report of two cases. (12435017)
2002
25
Time- and frequency-domain estimation of early diabetic cardiovascular autonomic neuropathy. (11794718)
2001
26
Small-bowel bacterial overgrowth in diabetic subjects is associated with cardiovascular autonomic neuropathy. (10937525)
2000
27
Cardiovascular autonomic neuropathy in HIV infected patients. (10615315)
1999
28
Silent myocardial ischemia and cardiac autonomic neuropathy in diabetics. (10778618)
1999
29
Optimal parameters of short-term heart rate spectrogram for routine evaluation of diabetic cardiovascular autonomic neuropathy. (9696273)
1998
30
Autonomic neuropathy: diagnosis and impact on health in adolescents with diabetes. (9676995)
1998
31
Long-term effect of converting enzyme inhibition on circadian sympathetic and parasympathetic modulation in patients with diabetic autonomic neuropathy. (9842405)
1998
32
Gemcitabine-associated autonomic neuropathy. (9500323)
1998
33
Clinical report of 60 cases of diabetic cardio-vascular autonomous neuropathy by stasis removing treatment of combined traditional and Western medicine]. (10322888)
1997
34
Severe autonomic neuropathy treated with subcutaneous insulin infusion. (8720543)
1996
35
Association of autonomic neuropathies and gastrointestinal peptides in non-insulin dependent diabetics]. (7739457)
1994
36
Response of pancreatic polypeptide to a protein rich meal in insulin non dependent diabetes melitus and autonomic neuropathy]. (17974412)
1994
37
Mechanisms of arterial hypotension after therapeutic dose of subcutaneous insulin in diabetic autonomic neuropathy. (8513972)
1993
38
A double-blind crossover study of oral xamoterol in postural hypotension due to diabetic autonomic neuropathy. (1688039)
1991
39
Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function. (1993010)
1991
40
Evaluation of the vagal-sympathetic interaction in diabetics with autonomic neuropathy through power spectrum density analysis of the heart rate. A critical revision of the natural history of diabetic autonomic neuropathy is possible. (2737507)
1989
41
Impaired catecholamine secretion as a cause of diabetic autonomic neuropathy. (3286167)
1988
42
Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death? (3355728)
1988
43
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
44
Diabetic autonomic neuropathy in BB rat. Ultrastructural and morphometric changes in parasympathetic nerves. (3721060)
1986
45
Sympathetic defects in diabetic autonomic neuropathy. (3833449)
1985
46
Cardiorespiratory arrest in a patient with advanced diabetic autonomic neuropathy. (3836109)
1985
47
Diabetic autonomic neuropathy in the BB rat. Ultrastructural and morphometric changes in sympathetic nerves. (4007283)
1985
48
Breathing, sleep, and diabetic autonomic neuropathy. (6500185)
1984
49
Postural hypotension in chronic renal failure due to autonomic neuropathy. (7287369)
1981
50
Diabetic autonomic neuropathy. (387501)
1979

Genetic Variations for Autonomic Neuropathy

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Expression for genes affiliated with Autonomic Neuropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autonomic Neuropathy

Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for genes affiliated with Autonomic Neuropathy

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Pathways related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NGF, NTRK1
2
Hide members
10.3NTRK1, NGF
310.3NGFR, NGF
4
Hide members
10.3NGFR, NGF
5
Hide members
10.3NGF, NGFR
610.3NGFR, NGF
710.3SPTLC1, SPTLC2
810.2NTF3, NGFR, NGF
9
Hide members
10.1NTRK1, NTF3, NGFR, NGF
1010.1NTRK1, NTF3, NGFR, NGF
1110.1NTRK1, NTF3, NGFR, NGF
1210.1NGF, NGFR, NTF3, NTRK1
13
Hide members
9.9INS, EPO, NGFR, NTF3, NTRK1
14
Hide members
9.9CCK, GAST, MLNR, MLN
159.9GAD1, NTRK1, DBH, NGFR, NGF
16
Hide members
9.5CCK, GAST, MLNR, MLN, NTRK1, NGFR

Compounds for genes affiliated with Autonomic Neuropathy

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Sources:
59Tocris Bioscience, 44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1ana 125910.6NGF, NGFR, NTRK1
2bdnf (human)5910.6NGF, NTRK1, NGFR
3tlqp 215910.6NGF, NTRK1, NGFR
4gnf 58375910.6NTRK1, NGF, NGFR
57,8-dihydroxyflavone44 5911.6NTRK1, NGF, NGFR
6k252a4410.5NGF, NGFR, NTF3, NTRK1
7bethanechol44 28 1112.4CCK, MLN, GAST
8gnrh4410.4DBH, GAST, NTRK1, GAD1
9norepinephrine44 11 2412.4GAST, NTF3, CCK, DBH
10streptozotocin4410.4GAD1, AKR1B1, NTF3, INS
11nicotinamide44 1111.4AKR1B1, GAST, EPO, INS
12ondansetron44 49 11 2413.4MLN, EPO, GAST, CCK
13ganglioside4410.4NGF, NTRK1, NGFR, NTF3
14cisapride44 28 1112.3MLN, MLNR, CCK
15atropine44 28 1112.3GAST, MLN, NGF, CCK
16neomycin4410.3EPO, NGF, GAST, CCK
17ceramide4410.3NTRK1, NGFR, SPTLC2, NGF, SPTLC1
18tetrodotoxin44 59 2812.3MLN, CCK, GAD1, NTF3
19c-peptide4410.3INS, GAST, GAD1, CCK
20octreotide44 59 28 1113.3CCK, GAST, EPO, MLN, INS
21metoclopramide44 1111.3CCK, MLN, DBH
22choline44 11 2412.2NTRK1, GAD1, NGFR, DBH, NTF3, NGF
23nicotine44 49 28 1113.2NGFR, DBH, NTF3, GAST, NGF
24levodopa44 1111.2DBH, AKR1B1, NGF, GAD1
25serine4410.2WNK1, SPTLC1, SPTLC2, MLN, AKR1B1, DBH
26wortmannin4410.2NTF3, NGFR, NGF, INS, WNK1, NTRK1
27oxyntomodulin44 5911.2MLN, GAST, CCK
28phenylalanine4410.1NGFR, CCK, DBH, NTRK1, MLN
29gaba4410.1GAST, GAD1, CCK, NTF3, NGFR, DBH
30acth4410.1CCK, DBH, GAST, INS, MLN
31catecholamine4410.1NGFR, NTRK1, DBH, NTF3
32creatinine4410.1GAST, NGF, EPO, GAD1, INS, AKR1B1
33epinephrine44 11 2412.0GAST, AKR1B1, INS, DBH, NGF
34histamine44 28 2412.0MLN, CCK, NGF, NGFR, DBH, NTF3
35testosterone44 59 11 2413.0CCK, EPO, NTRK1, INS, NGF, GAST
36phosphatidylinositol4410.0WNK1, NTRK1, NTF3, NGFR, NGF, EPO
37adenylate4410.0NTRK1, GAST, MLN, DBH, NTF3, CCK
38vegf4410.0NGF, NGFR, NTF3, NTRK1, AKR1B1, EPO
39ranitidine44 28 11 2413.0MLN, GAST, CCK
40arginine449.9INS, NGF, NTF3, MLN, CCK, AKR1B1
41glutamate449.8CCK, NGF, NGFR, INS, GAD1, GAST
42acetylcholine44 49 28 11 2413.8GAST, CCK, NTRK1, NTF3, DBH, NGFR
43alanine449.8INS, AKR1B1, NGF, GAD1, GAST, MLNR
44cyclic amp44 2410.8HCN3, NTRK1, DBH, NGFR, NGF, NTF3
45glucose449.8INS, DBH, MLN, NGFR, GAD1, GAST
46nmda44 2810.8GAD1, AKR1B1, NTF3, NGF
47dopamine44 28 11 2412.7MLNR, NTRK1, NGF, NGFR, DBH, NTF3
48oxygen44 2410.7NGFR, GAD1, NTRK1, DBH, EPO, NTF3
49calcium44 49 11 2412.5DBH, NGFR, NTRK1, MLN, MLNR, GAST
50tyrosine449.5GAD1, NTF3, CCK, GAST, MLN, NTRK1

GO Terms for genes affiliated with Autonomic Neuropathy

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16Gene Ontology
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Cellular components related to Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.2INS, DBH
2serine C-palmitoyltransferase complexGO:01705910.0SPTLC2, SPTLC1
3extracellular regionGO:0055769.3INS, CCK, GAST, MLN, NTF3, DBH

Biological processes related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1sphinganine biosynthetic processGO:04651110.5SPTLC2, SPTLC1
2sphingomyelin biosynthetic processGO:00668610.5SPTLC2, SPTLC1
3mechanoreceptor differentiationGO:04249010.5NTRK1, NTF3
4sphingosine biosynthetic processGO:04651210.5SPTLC1, SPTLC2
5response to electrical stimulusGO:05160210.5EPO, NGF, NTRK1
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.4NGF, NTF3, NTRK1
7regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.4NGF, NGFR
8positive regulation of protein autophosphorylationGO:03195410.3INS, NGF
9positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.3INS, NTF3, CCK
10positive regulation of Ras protein signal transductionGO:04657910.3EPO, NTRK1
11glucose homeostasisGO:04259310.3DBH, NGFR, INS
12nerve developmentGO:02167510.3NGFR, NTF3
13negative regulation of neuron apoptotic processGO:04352410.1NTRK1, NTF3, NGF
14G-protein coupled receptor signaling pathwayGO:0071869.6INS, MLN, MLNR, GAST

Molecular functions related to Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.1SPTLC2, SPTLC1, GAD1
2nerve growth factor bindingGO:04840610.1NTRK1, NTF3, NGFR
3serine C-palmitoyltransferase activityGO:00475810.0SPTLC2, SPTLC1
4hormone activityGO:0051799.8INS, EPO, MLN, GAST, CCK

Products for genes affiliated with Autonomic Neuropathy

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Autonomic Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet