MCID: ATN004
MIFTS: 49

Autonomic Neuropathy malady

Neuronal diseases category
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Summaries for Autonomic Neuropathy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Dysautonomia (or autonomic dysfunction, autonomic neuropathy) is a condition in which the autonomic... more...

MalaCards: Autonomic Neuropathy is related to neuropathy and diabetic autonomic neuropathy. An important gene associated with Autonomic Neuropathy is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are BDNF signaling pathway and Apoptosis. The compounds cipa and ag 879 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are vision/eye and muscle.

Aliases & Classifications for Autonomic Neuropathy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autonomic neuropathy 8 10 45 62


External Ids:

Disease Ontology8 DOID:11504
SNOMED-CT58 277879009
NCIt40 C27033

Related Diseases for Autonomic Neuropathy

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17GeneCards, 18GeneDecks
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Diseases in the Autonomic Dysfunction family:

autonomic neuropathy

Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.1IKBKAP, NGF, AKR1B1
2diabetic autonomic neuropathy31.9AKR1B1, NGF
3anhidrosis30.6NTRK1, NGF
4peripheral neuropathy30.6WNK1, NTRK1
5polyneuropathy30.6AKR1B1
6riley-day syndrome30.6NTRK1, IKBKAP
7diabetic polyneuropathy30.4NGF, AKR1B1
8hereditary sensory neuropathy30.4NTRK1, IKBKAP, NGF
9prion disease30.3NTRK1, NGF
10diabetic neuropathy30.2AKR1B1, NGF, NTRK1
11neuroblastoma30.0NGF, NTRK1
12diabetes mellitus10.9
13hereditary sensory and autonomic neuropathy type ii10.8
14hereditary sensory and autonomic neuropathy type v10.6
15postural hypotension10.6
16type 2 diabetes mellitus10.6
17pancreatitis10.5
18congenital insensitivity to pain with anhidrosis10.5
19dnmt1-related dementia, deafness, and sensory neuropathy10.5
20hypoglycemia10.5
21type 1 diabetes mellitus10.5
22dysautonomia10.4
23amyloidosis10.4
24artery disease10.4
25hypertension10.4
26hereditary sensory and autonomic neuropathy type vi10.4
27hereditary sensory and autonomic neuropathy type 1b10.4
28idiopathic peripheral autonomic neuropathy10.3
29atherosclerosis10.3
30obesity10.3
31coronary artery disease10.3
32cerebritis10.3
33hereditary sensory neuropathy type 110.3
34x-linked hereditary sensory and autonomic neuropathy with deafness10.3
35iritis10.2
36neuronitis10.2
37esophagitis10.2
38hepatitis10.2
39ischemia10.2
40myocardial infarction10.2
41porphyria10.2
42autoimmune gastrointestinal dysmotility10.2
43hereditary sensory and autonomic neuropathy type ic10.2
44hereditary sensory and autonomic neuropathy type iia10.2
45hereditary sensory and autonomic neuropathy type iib10.2
46blindness10.2
47hereditary sensory and autonomic neuropathy with deafness and global delay10.2
48diabetic nephropathy10.1
49peripheral artery disease10.1
50obstructive sleep apnea10.1

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to autonomic neuropathy

Symptoms for Autonomic Neuropathy

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Drugs & Therapeutics for Autonomic Neuropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Autonomic Neuropathy

Search NIH Clinical Center for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

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Anatomical Context for Autonomic Neuropathy

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33MalaCards
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MalaCards organs/tissues related to Autonomic Neuropathy:

33
Heart, Testes, Brain, Spinal cord, Skin, Liver, Kidney, Pancreas, B cells, Colon, Bone marrow, Eye, Lung, Bone, Pancreatic islet

Animal Models for Autonomic Neuropathy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Autonomic Neuropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5NGF, AKR1B1, IKBKAP, NTRK1
2MP:00053698.5NTRK1, IKBKAP, WNK1, NGF
3MP:00107718.3KIF1A, NTRK1, IKBKAP, NGF
4MP:00053867.7NGF, AKR1B1, IKBKAP, NTRK1, KIF1A
5MP:00036317.5NGF, WNK1, IKBKAP, NTRK1, KIF1A
6MP:00053787.3KIF1A, NTRK1, IKBKAP, WNK1, AKR1B1, NGF
7MP:00107687.3NGF, AKR1B1, WNK1, IKBKAP, NTRK1, KIF1A

Publications for Autonomic Neuropathy

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52PubMed
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Articles related to Autonomic Neuropathy:

(show top 50)    (show all 738)
idTitleAuthorsYear
1
Diabetic cardiac autonomic neuropathy: insights from animal models. (23562143)
2013
2
Retraction. A novel quantitative method for diabetic cardiac autonomic neuropathy assessment in type I diabetic mice. (23504179)
2013
3
Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation. (23596073)
2013
4
Haemodynamic changes during a squat test, pulsatile stress and indices of cardiovascular autonomic neuropathy in patients with long-duration type 1 diabetes. (22030241)
2012
5
Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort. (22302274)
2012
6
Diabetic gastrointestinal autonomic neuropathy: current status and new achievements for everyday clinical practice. (22863425)
2012
7
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
8
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. (21247746)
2011
9
Cardiovascular autonomic neuropathy in chronic kidney diseases. (21485597)
2010
10
Autonomic neuropathy predisposes to rosiglitazone-induced vascular leakage in insulin-treated patients with type 2 diabetes: a randomised, controlled trial on thiazolidinedione-induced vascular leakage. (20499046)
2010
11
Encephalitis and acute autonomic neuropathy. (19901720)
2009
12
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. (20156724)
2009
13
Ergotamine use in severe diabetic autonomic neuropathy. (17227338)
2007
14
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. (16389160)
2006
15
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
16
Comparative neuropathology and diabetic autonomic neuropathy. (14578168)
2003
17
The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. (12766130)
2003
18
Diabetic autonomic neuropathy causing gall bladder dysfunction. (11848318)
2001
19
Cerebrovascular reactivity and hypercapnic respiratory drive in diabetic autonomic neuropathy. (11181597)
2001
20
Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients. (11710799)
2001
21
Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. (11764088)
2001
22
Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. (10746489)
2000
23
Cardiac autonomic neuropathy in patients with chronic renal failure on hemodialysis. (10754407)
2000
24
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
25
Prevalence of central autonomic neuropathy in elderly dialysis patients. (9681715)
1998
26
Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. (9539642)
1998
27
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
28
Impact of liver transplantation on autonomic neuropathy in familial amyloidotic polyneuropathy: an evaluation by spectral analysis of heart rate variability. (9350167)
1997
29
High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy. (8070615)
1994
30
Circadian rhythmicity of heart rate and QTc interval in diabetic autonomic neuropathy: implications for the mechanism of sudden death. (8438703)
1993
31
Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. (8243821)
1993
32
QT interval in diabetic autonomic neuropathy. (2147640)
1990
33
Hypertension caused by clonidine in patients with diabetic autonomic neuropathy. (3608808)
1987
34
Abnormal diurnal urinary sodium and water excretion in diabetic autonomic neuropathy. (3477352)
1987
35
Metabolic and cardiovascular responses to epinephrine in diabetic autonomic neuropathy. (3614285)
1987
36
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
37
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
38
Sympathetic defects in diabetic autonomic neuropathy. (3833449)
1985
39
Norepinephrine secretion and production in diabetic autonomic neuropathy. (6736202)
1984
40
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6401569)
1983
41
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
42
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
43
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (6761211)
1982
44
A new test to study diabetic autonomic neuropathy. (7227703)
1981
45
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
46
Gastric emptying in diabetic autonomic neuropathy. (6769774)
1980
47
Clinical features of diabetic autonomic neuropathy. (6929778)
1980
48
Lack of glucagon response to hypoglycemia in diabetic autonomic neuropathy. (838171)
1977
49
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975
50
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975

Variations for Autonomic Neuropathy

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Expression for genes affiliated with Autonomic Neuropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autonomic Neuropathy

Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for genes affiliated with Autonomic Neuropathy

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 60Thomson Reuters
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Compounds for genes affiliated with Autonomic Neuropathy

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1cipa4510.0NTRK1, NGF
2ag 8794510.0NGF, NTRK1
3ana 126110.0NGF, NTRK1
4tlqp 216110.0NGF, NTRK1
5bdnf (human)6110.0NGF, NTRK1
6gnf 58376110.0NGF, NTRK1
77,8-dihydroxyflavone61 4511.0NGF, NTRK1
8propentofylline459.9NTRK1, NGF
9kt 582345 2910.9NGF, NTRK1
10k252a459.9NTRK1, NGF
11c2ceramide459.9NTRK1, NGF
12ganglioside459.8NGF, NTRK1
13alpha lipoic acid459.8AKR1B1, NGF
14cytarabine45 51 1111.7NTRK1, NGF
15levodopa45 1110.7NGF, AKR1B1
16p003459.5NTRK1, AKR1B1
17quercetin45 61 24 1112.5AKR1B1, NGF
18wortmannin459.4NGF, WNK1, NTRK1
19dihydrotestosterone45 29 24 1112.4NGF, AKR1B1
20phosphoinositide459.4NTRK1, WNK1, NGF
21capsaicin45 2910.4NTRK1, AKR1B1, NGF
22aspirin45 51 29 2412.3NTRK1, AKR1B1, NGF
23choline45 24 1111.3NTRK1, NGF
24genistein45 29 61 3 24 1114.3NGF, AKR1B1, NTRK1
25creatinine459.3NTRK1, AKR1B1, NGF
26adenylate459.2NGF, AKR1B1, NTRK1
27cycloheximide459.2NTRK1, AKR1B1, NGF
28testosterone45 61 24 1112.2NTRK1, AKR1B1, NGF
29phosphatidylinositol459.1NGF, WNK1, NTRK1
30vegf459.1NTRK1, AKR1B1, NGF
31alanine459.0NTRK1, AKR1B1, NGF
32threonine459.0NGF, WNK1, IKBKAP, NTRK1
33serine458.3NGF, AKR1B1, WNK1, IKBKAP, NTRK1

GO Terms for genes affiliated with Autonomic Neuropathy

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16Gene Ontology
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Biological processes related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sensory perception of painGO:0192339.8FAM134B, NGF
2response to electrical stimulusGO:0516029.8NTRK1, NGF
3response to radiationGO:0093149.8NTRK1, NGF
4activation of MAPKK activityGO:0001869.7NGF, NTRK1
5activation of phospholipase C activityGO:0072029.6NTRK1, NGF
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:0071699.6NTRK1, NGF
7phosphatidylinositol-mediated signalingGO:0480159.6NTRK1, NGF
8Ras protein signal transductionGO:0072659.5NGF, NTRK1
9negative regulation of neuron apoptotic processGO:0435249.3NTRK1, NGF
10protein phosphorylationGO:0064689.2WNK1, IKBKAP, NTRK1

Products for genes affiliated with Autonomic Neuropathy

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Sources for Autonomic Neuropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet