MCID: ATN004
MIFTS: 52

Autonomic Neuropathy malady

Neuronal category

Summaries for Autonomic Neuropathy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Dysautonomia (or autonomic dysfunction) is any disease or malfunction of the autonomic nervous system... more...

MalaCards: Autonomic Neuropathy is related to diabetic autonomic neuropathy and autonomic dysfunction. An important gene associated with Autonomic Neuropathy is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are TRKA activation by NGF and NGF-independant TRKA activation. The compounds ana 12 and bdnf (human) have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are muscle and vision/eye.

Aliases & Classifications for Autonomic Neuropathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

autonomic neuropathy 8 10 45 61


External Ids:

Disease Ontology8 DOID:11504
SNOMED-CT57 277879009
NCIt40 C27033

Related Diseases for Autonomic Neuropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the autonomic dysfunction family:

autonomic neuropathy

Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1diabetic autonomic neuropathy31.9AKR1B1, MLNR, NGF
2autonomic dysfunction30.9DBH, AKR1B1
3hypoglycemia30.7INS, DBH, GAD1, GAST, MLN, AKR1B1
4dysautonomia30.5DBH
5anhidrosis30.5NTRK1, NGF, NGFR
6riley-day syndrome30.5IKBKAP, DBH, NTRK1
7neuropathy hereditary sensory and autonomic type 130.4SPTLC2, SPTLC1
8diabetic polyneuropathy30.3AKR1B1, NTF3, NGF
9gastroparesis30.2INS, MLNR, GAST, CCK, MLN
10neuroaxonal dystrophy30.0NTF3, NGF, NTRK1
11dyspepsia30.0CCK, MLNR, MLN, GAST
12sensory peripheral neuropathy30.0SPTLC1, NGF, NTF3, NTRK1, AKR1B1
13pheochromocytoma29.9NGF, NGFR, DBH, NTF3, MLN, NTRK1
14hereditary sensory and autonomic neuropathy type ii10.7
15autonomic peripheral neuropathy10.7
16postural hypotension10.6
17n syndrome10.6
18hereditary sensory and autonomic neuropathy type v10.6
19dnmt1-related dementia, deafness, and sensory neuropathy10.5
20hereditary sensory and autonomic neuropathy iv10.5
21amyloid neuropathy10.4
22diabetic nephropathy10.4
23amyloidosis10.4
24hereditary sensory and autonomic neuropathy type vi10.4
25hereditary sensory and autonomic neuropathy type 1b10.4
26atherosclerosis10.3
27coronary artery disease,10.3
28idiopathic peripheral autonomic neuropathy10.3
29hereditary neuropathies10.3
30x-linked hereditary sensory and autonomic neuropathy with deafness10.3
31iritis10.2
32acute porphyria10.2
33hereditary sensory and autonomic neuropathy type ic10.2
34hereditary sensory and autonomic neuropathy type iia10.2
35hereditary sensory and autonomic neuropathy type iib10.2
36coronary heart disease10.2
37hereditary sensory and autonomic neuropathy with deafness and global delay10.2
38axonal neuropathy10.1
39uremic neuropathy10.1
40acute intermittent porphyria10.1
41tooth disease10.1
42hereditary sensory and autonomic neuropathy type iic10.1
43sleep apnea10.1
44amyloidosis, secondary10.1
45neuropathy, hereditary sensory, with spastic paraplegia10.1
46h. pylori infection10.1
47neuropathy, hereditary sensory and autonomic, type ia10.1
48cryoglobulinemia10.0
49lattice corneal dystrophy10.0
50reflex sympathetic dystrophy10.0

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to autonomic neuropathy

Clinical Features for Autonomic Neuropathy

Drugs & Therapeutics for Autonomic Neuropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autonomic Neuropathy

Drug clinical trials:

Search ClinicalTrials for Autonomic Neuropathy

Search NIH Clinical Center for Autonomic Neuropathy

Search CenterWatch for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

Anatomical Context for Autonomic Neuropathy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Autonomic Neuropathy:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Bone marrow, Heart, Colon, Pancreas, Salivary gland, Adrenal gland, T cells, B cells, Pancreatic islet

Animal Models for Autonomic Neuropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Autonomic Neuropathy

Sources:
51PubMed
See all sources

Articles related to Autonomic Neuropathy:

(show top 50)    (show all 777)
idTitleAuthorsYear
1
Transgenic expression of neuronal dystonin isoform 2 partially rescues the disease phenotype of the dystonia musculorum mouse model of hereditary sensory autonomic neuropathy VI. (24381311)
2014
2
Diabetic cardiac autonomic neuropathy: insights from animal models. (23562143)
2013
3
Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation. (23596073)
2013
4
Autonomic neuropathy in HIV is unrecognized and associated with medical morbidity. (24032624)
2013
5
Terminalia arjuna improves cardiovascular autonomic neuropathy in streptozotocin-induced diabetic rats. (23001577)
2013
6
What do we know and we do not know about cardiovascular autonomic neuropathy in diabetes. (22644723)
2012
7
Autonomic neuropathy is associated with impairment of dynamic cerebral autoregulation in type 1 diabetes. (21036672)
2011
8
Assessing autonomic dysfunction in early diabetic neuropathy: the Survey of Autonomic Symptoms. (21422460)
2011
9
The relationship between diabetic autonomic neuropathy and diabetic risk factors in a Taiwanese population. (21986117)
2011
10
Autonomic neuropathy in diabetes mellitus and obesity: an update. (22203830)
2011
11
There is No Association between Cardiovascular Autonomic Dysfunction and Peripheral Neuropathy in Chronic Hemodialysis Patients. (20944815)
2010
12
ECG body surface mapping changes in type 1 diabetic patients with and without autonomic neuropathy. (19537926)
2010
13
Hereditary sensory and autonomic neuropathy type IV orthopaedic complications. (19318985)
2009
14
Thymoma associated with myasthenia and autonomic anti-Hu paraneoplastic neuropathy. (19579874)
2009
15
A Pocket-size Device to Detect Autonomic Neuropathy. (19885246)
2008
16
Hereditary sensory and autonomic neuropathy type IV. (18705260)
2008
17
Heart rate variability and heart rate turbulence in patients with type 2 diabetes mellitus with versus without cardiac autonomic neuropathy. (17719340)
2007
18
Severe orthostatic hypotension with diabetic autonomic neuropathy successfully treated with a beta(1)-blocker: a case report. (16810280)
2006
19
Autonomic peripheral neuropathy. (15811460)
2005
20
Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy. (16043739)
2005
21
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
22
Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the study of Canadian genetic isolates. (15060842)
2004
23
HIV-associated adipose redistribution syndrome as a selective autonomic neuropathy. (14643128)
2003
24
Preclinical diabetic cardiomyopathy: relation of left ventricular diastolic dysfunction to cardiac autonomic neuropathy in men with uncomplicated well-controlled type 2 diabetes. (12898473)
2003
25
Experimental autoimmune autonomic neuropathy. (12773498)
2003
26
Incidence of cardiac autonomic neuropathy and its correlation with retinopathy, micro-albuminuria and glycated haemoglobin in non-insulin dependent diabetes mellitus. (12408270)
2002
27
Congenital insensitivity to pain (hereditary sensory and autonomic neuropathy) HSAN: a report of two cases. (12435017)
2002
28
Diabetic autonomic neuropathy. (11360064)
2000
29
Plasma epinephrine and norepinephrine response to stimuli in autonomic neuropathy of type 2 diabetes mellitus. (11194927)
2000
30
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
31
Natural killer cell lymphoproliferative disease associated with combined peripheral and autonomic neuropathy. (18639128)
1999
32
Neuronal nicotinic ACh receptor antibody in subacute autonomic neuropathy and cancer-related syndromes. (9633732)
1998
33
Cold pressor test in diabetic autonomic neuropathy. (7875046)
1994
34
Sudden cardiorespiratory arrest after renal transplantation in a patient with diabetic autonomic neuropathy and prolonged QT interval. (8067232)
1994
35
Spectral analysis of heart rate in diabetic autonomic neuropathy. A comparison with standard tests of autonomic function. (1993010)
1991
36
Diabetic autonomic neuropathy. (2320069)
1990
37
No effect of Pindolol on postural hypotension in type 1 (insulin-dependent) diabetic patients with autonomic neuropathy. A randomised double-blind controlled study. (3294067)
1988
38
Prolonged QT period in diabetic autonomic neuropathy: a possible role in sudden cardiac death? (3355728)
1988
39
Loss of spontaneous variability of fingertip anastomotic blood flow in diabetic autonomic neuropathy. (3581682)
1987
40
Apparent improvement in diabetic autonomic neuropathy induced by captopril. (3333529)
1987
41
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
42
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6402226)
1983
43
Reduced pupillary light reflexes in diabetic autonomic neuropathy. (6873511)
1983
44
Resting heart rate and diabetic autonomic neuropathy. (6954376)
1982
45
No response of pancreatic hormones to hypoglycemia in diabetic autonomic neuropathy. (6120949)
1982
46
Combination H1 and H2 receptor antagonist therapy in diabetic autonomic neuropathy. (6123154)
1982
47
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (7048157)
1982
48
Autonomic neuropathy in the skin: a histological study of the sympathetic nerve fibres in diabetic anhidrosis. (7060854)
1982
49
Painful myocardial infarction in severe diabetic autonomic neuropathy. (707002)
1978
50
Editorial: Structure and function in diabetic autonomic neuropathy. (1260268)
1976

Genetic Variations for Autonomic Neuropathy

Expression for genes affiliated with Autonomic Neuropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autonomic Neuropathy

Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for genes affiliated with Autonomic Neuropathy

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 52QIAGEN, 4Cell Signaling Technology
See all sources

Pathways related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3NGF, NTRK1
2
Hide members
10.3NTRK1, NGF
310.3NGFR, NGF
4
Hide members
10.3NGFR, NGF
5
Hide members
10.3NGF, NGFR
610.3NGF, NGFR
710.3SPTLC2, SPTLC1
810.2NGFR, NGF, NTF3
910.1NTRK1, NTF3, NGFR, NGF
1010.1NTRK1, NTF3, NGFR, NGF
1110.1NGF, NGFR, NTF3, NTRK1
12
Hide members
10.1NTF3, NTRK1, NGF, NGFR
13
Hide members
9.9INS, NTRK1, NTF3, NGFR, EPO
14
Hide members
9.9MLNR, MLN, CCK, GAST
159.9DBH, NTRK1, GAD1, NGFR, NGF
16
Hide members
9.5NTRK1, INS, NGF, MLN, MLNR, GAST

Compounds for genes affiliated with Autonomic Neuropathy

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1ana 126010.6NGF, NGFR, NTRK1
2bdnf (human)6010.6NGF, NTRK1, NGFR
3tlqp 216010.6NGF, NTRK1, NGFR
4gnf 58376010.6NTRK1, NGF, NGFR
57,8-dihydroxyflavone45 6011.6NTRK1, NGF, NGFR
6k252a4510.5NGF, NGFR, NTF3, NTRK1
7bethanechol45 29 1112.4CCK, MLN, GAST
8gnrh4510.4DBH, GAST, NTRK1, GAD1
9norepinephrine45 11 2412.4GAST, NTF3, CCK, DBH
10streptozotocin4510.4GAD1, AKR1B1, NTF3, INS
11nicotinamide45 1111.4AKR1B1, GAST, EPO, INS
12ondansetron45 50 11 2413.4MLN, EPO, GAST, CCK
13ganglioside4510.4NGF, NTRK1, NGFR, NTF3
14cisapride45 29 1112.3MLN, MLNR, CCK
15atropine45 29 1112.3GAST, MLN, NGF, CCK
16neomycin4510.3EPO, NGF, GAST, CCK
17ceramide4510.3NTRK1, NGFR, SPTLC2, NGF, SPTLC1
18tetrodotoxin45 60 2912.3MLN, CCK, GAD1, NTF3
19c-peptide4510.3INS, GAST, GAD1, CCK
20octreotide45 60 29 1113.3CCK, GAST, EPO, MLN, INS
21metoclopramide45 1111.3CCK, MLN, DBH
22choline45 11 2412.2NTRK1, GAD1, NGFR, DBH, NTF3, NGF
23nicotine45 50 29 1113.2NGFR, DBH, NTF3, GAST, NGF
24levodopa45 1111.2DBH, AKR1B1, NGF, GAD1
25serine4510.2WNK1, SPTLC1, SPTLC2, MLN, AKR1B1, DBH
26wortmannin4510.2NTF3, NGFR, NGF, INS, WNK1, NTRK1
27oxyntomodulin45 6011.2MLN, GAST, CCK
28phenylalanine4510.1NGFR, CCK, DBH, NTRK1, MLN
29gaba4510.1GAST, GAD1, CCK, NTF3, NGFR, DBH
30acth4510.1CCK, DBH, GAST, INS, MLN
31catecholamine4510.1NGFR, NTRK1, DBH, NTF3
32creatinine4510.1GAST, NGF, EPO, GAD1, INS, AKR1B1
33epinephrine45 11 2412.0GAST, AKR1B1, INS, DBH, NGF
34histamine45 29 2412.0MLN, CCK, NGF, NGFR, DBH, NTF3
35testosterone45 60 11 2413.0CCK, EPO, NTRK1, INS, NGF, GAST
36phosphatidylinositol4510.0WNK1, NTRK1, NTF3, NGFR, NGF, EPO
37adenylate4510.0NTRK1, GAST, MLN, DBH, NTF3, CCK
38vegf4510.0NGF, NGFR, NTF3, NTRK1, AKR1B1, EPO
39ranitidine45 29 11 2413.0MLN, GAST, CCK
40arginine459.9INS, NGF, NTF3, MLN, CCK, AKR1B1
41glutamate459.8CCK, NGF, NGFR, INS, GAD1, GAST
42acetylcholine45 50 29 11 2413.8GAST, CCK, NTRK1, NTF3, DBH, NGFR
43alanine459.8INS, AKR1B1, NGF, GAD1, GAST, MLNR
44cyclic amp45 2410.8HCN3, NTRK1, DBH, NGFR, NGF, NTF3
45glucose459.8INS, DBH, MLN, NGFR, GAD1, GAST
46nmda45 2910.8GAD1, AKR1B1, NTF3, NGF
47dopamine45 29 11 2412.7MLNR, NTRK1, NGF, NGFR, DBH, NTF3
48oxygen45 2410.7NGFR, GAD1, NTRK1, DBH, EPO, NTF3
49calcium45 50 11 2412.5DBH, NGFR, NTRK1, MLN, MLNR, GAST
50tyrosine459.5GAD1, NTF3, CCK, GAST, MLN, NTRK1

GO Terms for genes affiliated with Autonomic Neuropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:03477410.2INS, DBH
2serine C-palmitoyltransferase complexGO:01705910.0SPTLC2, SPTLC1
3extracellular regionGO:0055769.3INS, CCK, GAST, MLN, NTF3, DBH

Biological processes related to Autonomic Neuropathy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1sphinganine biosynthetic processGO:04651110.5SPTLC2, SPTLC1
2sphingomyelin biosynthetic processGO:00668610.5SPTLC2, SPTLC1
3mechanoreceptor differentiationGO:04249010.5NTRK1, NTF3
4sphingosine biosynthetic processGO:04651210.5SPTLC1, SPTLC2
5response to electrical stimulusGO:05160210.5EPO, NGF, NTRK1
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.4NGF, NTF3, NTRK1
7regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.4NGF, NGFR
8positive regulation of protein autophosphorylationGO:03195410.3INS, NGF
9positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.3INS, NTF3, CCK
10positive regulation of Ras protein signal transductionGO:04657910.3EPO, NTRK1
11glucose homeostasisGO:04259310.3DBH, NGFR, INS
12nerve developmentGO:02167510.3NGFR, NTF3
13negative regulation of neuron apoptotic processGO:04352410.1NTRK1, NTF3, NGF
14G-protein coupled receptor signaling pathwayGO:0071869.6INS, MLN, MLNR, GAST

Molecular functions related to Autonomic Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pyridoxal phosphate bindingGO:03017010.1SPTLC2, SPTLC1, GAD1
2nerve growth factor bindingGO:04840610.1NTF3, NGFR, NTRK1
3serine C-palmitoyltransferase activityGO:00475810.0SPTLC1, SPTLC2
4hormone activityGO:0051799.8CCK, INS, EPO, MLN, GAST

Products for genes affiliated with Autonomic Neuropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autonomic Neuropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet