MCID: ATN004
MIFTS: 41

Autonomic Neuropathy malady

Neuronal diseases category

Aliases & Classifications for Autonomic Neuropathy

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Aliases & Descriptions for Autonomic Neuropathy:

Name: Autonomic Neuropathy 8 10 44 61


Classifications:



External Ids:

Disease Ontology8 DOID:11504
SNOMED-CT56 277879009
NCIt39 C27033

Summaries for Autonomic Neuropathy

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Wikipedia:64 Dysautonomia (or autonomic dysfunction, autonomic neuropathy) is a condition in which the autonomic... more...

MalaCards based summary: Autonomic Neuropathy is related to neuropathy and diabetic autonomic neuropathy. An important gene associated with Autonomic Neuropathy is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are BDNF signaling pathway and Apoptosis. The compounds cipa and ag 879 have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are vision/eye and muscle.

Related Diseases for Autonomic Neuropathy

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Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1neuropathy32.2IKBKAP, AKR1B1, NGF
2diabetic autonomic neuropathy32.1AKR1B1, NGF
3polyneuropathy31.0AKR1B1
4dysautonomia, familial31.0NTRK1, IKBKAP
5anhidrosis30.9NGF, NTRK1
6peripheral neuropathy30.8WNK1, NTRK1
7diabetic polyneuropathy30.7AKR1B1, NGF
8prion disease30.4NTRK1, NGF
9hereditary sensory neuropathy30.4NGF, IKBKAP, NTRK1
10diabetic neuropathy30.2NTRK1, AKR1B1, NGF
11neuroblastoma29.9NTRK1, NGF
12neuropathy, hereditary sensory and autonomic, type ii10.8
13postural hypotension10.6
14dnmt1-related dementia, deafness, and sensory neuropathy10.6
15neuropathy, hereditary sensory and autonomic, type v10.6
16pancreatitis10.6
17hypoglycemia10.5
18insensitivity to pain, congenital, with anhidrosis10.4
19dysautonomia10.4
20idiopathic peripheral autonomic neuropathy10.4
21amyloidosis10.4
22obesity10.4
23artery disease10.4
24atherosclerosis10.3
25cerebritis10.3
26blindness10.3
27neuropathy, hereditary sensory and autonomic, type vi10.3
28neuropathy, hereditary sensory and autonomic, type ia10.3
29myocardial infarction10.3
30coronary artery disease10.3
31neuropathy, hereditary sensory, type ib10.3
32arthritis10.3
33hepatitis10.3
34iritis10.3
35neuronitis10.3
36esophagitis10.3
37ischemia10.3
38porphyria10.3
39autoimmune gastrointestinal dysmotility10.3
40hereditary sensory and autonomic neuropathy type iic10.3
41hereditary sensory and autonomic neuropathy with deafness and global delay10.3
42x-linked hereditary sensory and autonomic neuropathy with deafness10.3
43hereditary sensory and autonomic neuropathy with spastic paraplegia10.3
44chronic diarrhea with hereditary sensory and autonomic neuropathy10.3
45adrenal neuroblastoma10.2KIF1A
46neuroaxonal dystrophy10.2NGF, NTRK1
47rheumatoid arthritis10.2
48neuropathy, hereditary sensory and autonomic, type vii10.2
49charcot-marie-tooth disease10.2
50peripheral artery disease10.2

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to autonomic neuropathy

Symptoms for Autonomic Neuropathy

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Drugs & Therapeutics for Autonomic Neuropathy

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Drug clinical trials:

Search ClinicalTrials for Autonomic Neuropathy

Search NIH Clinical Center for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

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Anatomical Context for Autonomic Neuropathy

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MalaCards organs/tissues related to Autonomic Neuropathy:

31
Heart, Testes, Brain, Spinal cord, Skin, Liver, Kidney, Bone marrow, Eye, Bone, Colon, Lung, Pancreas, B cells, Pancreatic islet

Animal Models for Autonomic Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Autonomic Neuropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5NGF, AKR1B1, IKBKAP, NTRK1
2MP:00053698.5NTRK1, IKBKAP, WNK1, NGF
3MP:00107718.3KIF1A, NTRK1, IKBKAP, NGF
4MP:00053867.7NGF, AKR1B1, IKBKAP, NTRK1, KIF1A
5MP:00036317.5NGF, WNK1, IKBKAP, NTRK1, KIF1A
6MP:00053787.3KIF1A, NTRK1, IKBKAP, WNK1, AKR1B1, NGF
7MP:00107687.3NGF, AKR1B1, WNK1, IKBKAP, NTRK1, KIF1A

Publications for Autonomic Neuropathy

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Articles related to Autonomic Neuropathy:

(show top 50)    (show all 782)
idTitleAuthorsYear
1
Gut symptoms in diabetics correlate with components of the recto-anal inhibitory reflex, but not with pudendal nerve motor latencies or systemic autonomic neuropathy. (25761939)
2015
2
Diabetic cardiac autonomic neuropathy: insights from animal models. (23562143)
2013
3
Retraction. A novel quantitative method for diabetic cardiac autonomic neuropathy assessment in type I diabetic mice. (23504179)
2013
4
Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation. (23596073)
2013
5
Haemodynamic changes during a squat test, pulsatile stress and indices of cardiovascular autonomic neuropathy in patients with long-duration type 1 diabetes. (22030241)
2012
6
Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort. (22302274)
2012
7
Diabetic gastrointestinal autonomic neuropathy: current status and new achievements for everyday clinical practice. (22863425)
2012
8
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
9
Recommendations for the use of cardiovascular tests in diagnosing diabetic autonomic neuropathy. (21247746)
2011
10
Cardiovascular autonomic neuropathy in chronic kidney diseases. (21485597)
2010
11
Autonomic neuropathy predisposes to rosiglitazone-induced vascular leakage in insulin-treated patients with type 2 diabetes: a randomised, controlled trial on thiazolidinedione-induced vascular leakage. (20499046)
2010
12
Encephalitis and acute autonomic neuropathy. (19901720)
2009
13
Cough reflex sensitivity in adolescents with diabetic autonomic neuropathy. (20156724)
2009
14
Ergotamine use in severe diabetic autonomic neuropathy. (17227338)
2007
15
Effect of quinapril or losartan alone and in combination on left ventricular systolic and diastolic functions in asymptomatic patients with diabetic autonomic neuropathy. (16389160)
2006
16
Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers. (15574133)
2004
17
Comparative neuropathology and diabetic autonomic neuropathy. (14578168)
2003
18
The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. (12766130)
2003
19
Diabetic autonomic neuropathy causing gall bladder dysfunction. (11848318)
2001
20
Cerebrovascular reactivity and hypercapnic respiratory drive in diabetic autonomic neuropathy. (11181597)
2001
21
Changes of gastric emptying rate and gastrin levels are early indicators of autonomic neuropathy in type II diabetic patients. (11710799)
2001
22
Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes. (11764088)
2001
23
Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. (10746489)
2000
24
Cardiac autonomic neuropathy in patients with chronic renal failure on hemodialysis. (10754407)
2000
25
Sensory and autonomic neuropathy in patients with idiopathic slow-transit constipation. (10027360)
1999
26
Prevalence of central autonomic neuropathy in elderly dialysis patients. (9681715)
1998
27
Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. (9539642)
1998
28
Cholecystoparesis with diabetic autonomic neuropathy. (9313105)
1997
29
Impact of liver transplantation on autonomic neuropathy in familial amyloidotic polyneuropathy: an evaluation by spectral analysis of heart rate variability. (9350167)
1997
30
High prevalence of autoantibodies to glutamic acid decarboxylase in long-standing IDDM is not a marker of symptomatic autonomic neuropathy. (8070615)
1994
31
Circadian rhythmicity of heart rate and QTc interval in diabetic autonomic neuropathy: implications for the mechanism of sudden death. (8438703)
1993
32
Relationship between the circadian rhythms of blood pressure and sympathovagal balance in diabetic autonomic neuropathy. (8243821)
1993
33
QT interval in diabetic autonomic neuropathy. (2147640)
1990
34
Hypertension caused by clonidine in patients with diabetic autonomic neuropathy. (3608808)
1987
35
Abnormal diurnal urinary sodium and water excretion in diabetic autonomic neuropathy. (3477352)
1987
36
QT interval prolongation and sudden cardiac death in diabetic autonomic neuropathy. (3818902)
1987
37
Abnormal circadian rhythm of melatonin in diabetic autonomic neuropathy. (3742831)
1986
38
Sympathetic defects in diabetic autonomic neuropathy. (3833449)
1985
39
Norepinephrine secretion and production in diabetic autonomic neuropathy. (6736202)
1984
40
Reduced sinus arrhythmia in diabetic autonomic neuropathy. (6401569)
1983
41
The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation. (6096985)
1983
42
Axonal dystrophy in experimental diabetic autonomic neuropathy. (7160544)
1982
43
Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal, and metabolic studies. (6761211)
1982
44
A new test to study diabetic autonomic neuropathy. (7227703)
1981
45
Hormonal, metabolic, and cardiovascular responses to hypoglycemia in diabetic autonomic neuropathy. (7018967)
1981
46
Gastric emptying in diabetic autonomic neuropathy. (6769774)
1980
47
Clinical features of diabetic autonomic neuropathy. (6929778)
1980
48
Lack of glucagon response to hypoglycemia in diabetic autonomic neuropathy. (838171)
1977
49
9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. (1094320)
1975
50
Defective innervation of heart in diabetic autonomic neuropathy. (1131653)
1975

Variations for Autonomic Neuropathy

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Expression for genes affiliated with Autonomic Neuropathy

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Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for genes affiliated with Autonomic Neuropathy

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Compounds for genes affiliated with Autonomic Neuropathy

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Compounds related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1cipa4410.0NTRK1, NGF
2ag 8794410.0NGF, NTRK1
3bdnf (human)6010.0NGF, NTRK1
4tlqp 216010.0NTRK1, NGF
5ana 126010.0NGF, NTRK1
6gnf 58376010.0NTRK1, NGF
77,8-dihydroxyflavone60 4411.0NTRK1, NGF
8propentofylline449.9NTRK1, NGF
9kt 582344 2810.9NGF, NTRK1
10k252a449.9NGF, NTRK1
11c2ceramide449.9NGF, NTRK1
12ganglioside449.8NTRK1, NGF
13alpha lipoic acid449.8AKR1B1, NGF
14cytarabine44 50 1111.7NGF, NTRK1
15levodopa44 1110.7AKR1B1, NGF
16p003449.5AKR1B1, NTRK1
17quercetin44 60 24 1112.5NGF, AKR1B1
18wortmannin449.4WNK1, NGF, NTRK1
19dihydrotestosterone44 28 24 1112.4AKR1B1, NGF
20phosphoinositide449.4NGF, NTRK1, WNK1
21capsaicin44 2810.4NTRK1, NGF, AKR1B1
22aspirin44 50 28 2412.3AKR1B1, NTRK1, NGF
23choline44 24 1111.3NTRK1, NGF
24genistein44 28 60 1 24 1114.3NTRK1, AKR1B1, NGF
25creatinine449.3AKR1B1, NTRK1, NGF
26adenylate449.2NGF, NTRK1, AKR1B1
27cycloheximide449.2NGF, NTRK1, AKR1B1
28testosterone44 60 24 1112.2AKR1B1, NTRK1, NGF
29phosphatidylinositol449.1NGF, NTRK1, WNK1
30vegf449.1AKR1B1, NGF, NTRK1
31alanine449.0NTRK1, NGF, AKR1B1
32threonine449.0NGF, IKBKAP, NTRK1, WNK1
33serine448.3WNK1, IKBKAP, NTRK1, NGF, AKR1B1

GO Terms for genes affiliated with Autonomic Neuropathy

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Biological processes related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1sensory perception of painGO:00192339.8FAM134B, NGF
2response to electrical stimulusGO:00516029.8NTRK1, NGF
3response to radiationGO:00093149.8NTRK1, NGF
4activation of MAPKK activityGO:00001869.7NGF, NTRK1
5activation of phospholipase C activityGO:00072029.6NTRK1, NGF
6transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.6NTRK1, NGF
7phosphatidylinositol-mediated signalingGO:00480159.6NTRK1, NGF
8Ras protein signal transductionGO:00072659.5NGF, NTRK1
9negative regulation of neuron apoptotic processGO:00435249.3NTRK1, NGF
10protein phosphorylationGO:00064689.2WNK1, IKBKAP, NTRK1

Sources for Autonomic Neuropathy

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet