Autonomic Neuropathy malady

Wikipedia: Dysautonomia (or autonomic dysfunction) is a broad term that describes any disease or malfunction of the...⁴⁴ more...

MalaCards: Autonomic Neuropathy, also known as autonomic neuropathy (disorder), is related to hereditary sensory and autonomic neuropathy type ii and hereditary sensory and autonomic neuropathy type v. An important gene associated with Autonomic Neuropathy is NGF (nerve growth factor (beta polypeptide)), and among its related pathways are Beta-alanine metabolism and Beta-alanine metabolism. The compounds glucose and bethanechol have been mentioned in the context of this disorder. Affiliated tissues include heart and lung, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Aliases & Descriptions:

autonomic neuropathy 6 8 32 43 autonomic neuropathy (disorder) 6

Diseases related to autonomic neuropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 371)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary sensory and autonomic neuropathy type ii	35.2	FAM134B, WNK1
2	hereditary sensory and autonomic neuropathy type v	34.7	NTRK1, NGF, NGFR
3	diabetic autonomic neuropathy	33.9	GCG, MLN, MLNR, INS, IGF1, AKR1B1
4	riley-day syndrome	32.4	IKBKAP, NTRK1, DBH
5	hereditary sensory neuropathy	31.8	IKBKAP, SPTLC2, SPTLC1, NTRK1, NGF
6	insensitivity to pain	29.6	NTRK1, NGF, NGFR
7	postural hypotension	29.5	REN, INS, DBH, NPPA, EPO
8	anhidrosis	29.1	CCT5, IKBKAP, NTRK1, NGF, NGFR
9	gastroparesis	28.8	GCG, MLN, MLNR, INS, CCK, IKBKAP
10	hypoaldosteronism	28.4	REN, INS, NPPA
11	diabetic neuropathy	28.3	INS, AKR1B1, NTF3, NTRK1, NGF, NGFR
12	orthostatic hypotension	28.0	REN, TTR, DBH, NPPA, EPO
13	peripheral neuropathy	27.9	INS, ALB, AKR1B1, SPTLC2, SPTLC1, NTF3
14	amyloidosis	27.4	INS, ALB, AGER, TTR, DBH, NPPA
15	coronary heart disease	27.1	GCG, INS, IGF1, ALB, AGER, NPPA
16	neuropathy	26.9	REN, KIF1A, GCG, RAB7A, MLN, MLNR
17	type 2 diabetes mellitus	26.9	GCG, INS, CCK, IGF1, ALB, AKR1B1
18	diabetes mellitus	26.5	REN, GCG, MLN, MLNR, INS, IL2RA
19	type 1 diabetes mellitus	25.9	GCG, MLNR, INS, IGF1, ALB, AKR1B1
20	hypoxia	25.6	REN, INS, IGF1, ALB, PTPN3, SPTLC1
21	nephropathy	25.6	REN, GCG, INS, IL2RA, IGF1, ALB
22	blindness	25.0	REN, GCG, MLN, MLNR, INS, IL2RA
23	insulin resistance	24.7	REN, GCG, RAB7A, INS, CCK, IGF1
24	anemia	24.6	REN, INS, IL2RA, IGF1, ALB, TBXAS1
25	pancreatitis	23.5	REN, GCG, MLN, MLNR, INS, IL2RA
26	neuroaxonal dystrophy	13.8	NTF3, NTRK1, NGF
27	autonomic dysfunction	13.7	AKR1B1, DBH
28	duodenogastric reflux	13.6	MLN, CCK, GAST
29	autoimmune polyendocrine syndrome type 2	13.6	INS, GAD2
30	diabetic polyneuropathy	13.6	AKR1B1, NTF3, NGF
31	calciphylaxis	13.6	INS, ALB, EPO
32	hyporeninemic hypoaldosteronism	13.6	REN, INS
33	sheehan syndrome	13.6	INS, IGF1, EPO
34	hypohidrosis	13.6	IKBKAP, SPTLC1, NTRK1
35	renal hypertension	13.6	REN, ALB, EPO
36	stiff-person syndrome	13.6	INS, GAD1, GAD2
37	autoimmune polyendocrine syndrome type 1	13.6	CCK, GAD1, GAD2
38	steatorrhea	13.6	GCG, MLN, CCK
39	protein-losing enteropathy	13.5	GCG, INS, ABP1
40	gastrointestinal system disease	13.5	GCG, MLN, CCK, GAST
41	diabetic macular edema	13.5	REN, INS, AKR1B1, EPO
42	autoimmune polyendocrine syndrome	13.5	INS, GAD1, GAD2
43	hirschsprung's disease	13.5	NTF3, NTRK1, NGFR, NPY
44	glucose intolerance	13.5	GCG, MLN, CCK, GAST
45	dyspepsia	13.5	MLN, MLNR, CCK, GAST
46	somatostatinoma	13.5	GCG, PPY, GAST
47	hypertrophic pyloric stenosis	13.5	MLN, IGF1, NGFR, GAST
48	pyloric stenosis	13.5	MLN, IGF1, NGFR, GAST
49	gallbladder disease	13.5	INS, CCK, ALB
50	morbid obesity	13.5	GCG, INS, CCK, GAD2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to autonomic neuropathy:

²²

MGI Mouse Phenotypes related to autonomic neuropathy:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.3	DST, NTRK1, TBXAS1, IKBKAP, EPO
2	renal/urinary system phenotype	MP:0005367	8.8	WNK1, NPPA, DST, NGFR, AKR1B1, INS
3	nervous system phenotype	MP:0003631	8.8	GAD2, GAD1, WNK1, NPY, DBH, NGF
4	integument phenotype	MP:0010771	8.7	DBH, DST, HBA2, NGFR, NGF, NTRK1
5	vision/eye phenotype	MP:0005391	8.6	NGFR, TTR, DST, DBH, NGF, NTRK1
6	normal phenotype	MP:0002873	8.2	AGER, NPY, EPO, GAD1, GAD2, NGFR
7	digestive/alimentary phenotype	MP:0005381	7.8	NPY, GAD1, GAD2, GAST, DST, NGFR
8	behavior/neurological phenotype	MP:0005386	7.6	NGFR, AGER, DST, DBH, NPY, GAD1
9	muscle phenotype	MP:0005369	7.4	GAD2, WNK1, NPPA, DST, AGER, HBA2
10	mortality/aging	MP:0010768	5.9	NGFR, HBA1, HBA2, DST, DBH, WNK1
11	growth/size phenotype	MP:0005378	5.8	NGFR, HBA2, AGER, DST, DBH, NPY
12	homeostasis/metabolism phenotype	MP:0005376	5.0	REN, AGER, TTR, DST, DBH, NPPA

Articles related to autonomic neuropathy:

(show top 50)    (show all 92)

id	Title	Authors	Year	Affiliating Genes
1	Hereditary sensory autonomic neuropathy caused by a mutation in dystonin. (22522446)	Edvardson S.... Elpeleg O.	2012	DST
2	Hereditary sensory and autonomic neuropathy II due to novel mutation in the HSN2 gene in Mexican families. (21625937)	Pacheco-Cuellar G.... Cuevas-Covarrubias S.A.	2011	WNK1
3	Taking pain out of NGF: a 'painless' NGF mu tant, linked to hereditary sensory autonomic neuropathy type V, with full neuro trophic activity. (21387003)	Capsoni S.... Cattaneo A.	2011	NGF
4	KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. (21820098)	Riviere J.B.... Rouleau G.A.	2011	KIF1A
5	In vitro receptor binding properties of a 'painl ess' NGF mutein, linked to hereditary sensory autonomic neuropathy type V. (19945432)	Covaceuszach S.... Cattaneo A.	2010	NTRK1, NGFR, NGF
6	Mutations in the SPTLC2 subunit of serine palmitoyltr ansferase cause hereditary sensory and autonomic neuropathy type I. (20920666)	Rotthier A.... Timmerman V.	2010	SPTLC2, SPTLC3
7	Carriers of recessive WNK1/HSN2 mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli. (19228968)	Loggia M.L.... Brais B.	2009	WNK1
8	Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. (19838196)	Kurth I.... Huebner C.A.	2009	FAM134B
9	Genes for hereditary sensory and autonomic neuropathi es: a genotype-phenotype correlation. (19651702)	Rotthier A.... Timmerman V.	2009	NTRK1, CCT5, NGF
10	Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. (17967455)	Schmidt R.E.... Brines M.	2008	EPO
11	Coefficient of variation of R-R intervals in electroc ardiogram is a sensitive marker of anemia induced by autonomic neuropathy in ty pe 1 diabetes. (17481773)	Saito T.... Tajima N.	2007	EPO
12	Hereditary sensory and autonomic neuropathy type I in a Chinese family: British C133W mutation exists in the Chinese. (18018475)	Bi H.... Yuan Y.	2007	SPTLC1
13	Clinical, pathological and genetic characterization of hereditary sensory and autonomic neuropathy type 1 (HSAN I). (16364956)	Houlden H.... Reilly M.M.	2006	SPTLC1
14	Performing only one cardiovascular reflex test has a high positive predictive value for diagnosing autonomic neuropathy in patients with chronic renal failure on hemodialysis. (16825086)	Sahin M.... Akdur S.	2006	ALB, EPO
15	L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy. (16217067)	Gibbons C.H.... Freeman R.	2005	EPO
16	The evaluation of autonomic nervous function in a patient with hereditary sensory and autonomic neuropathy type IV with novel mutations of the TRKA gene. (15534759)	Ohto T.... Matsui A.	2004	NTRK1
17	Severe and disabling diabetic autonomic neuropathy: a case report. (15120708)	Kamalakannan D.... Singh B.M.	2004	INS
18	Insulin resistant state in type 2 diabetes is related to advanced autonomic neuropathy. (12716078)	Nakano S.... Uchida K.	2003	INS
19	Neuroadrenergic denervation of the lung in type I dia betes mellitus complicated by autonomic neuropathy. (11834655)	Antonelli Incalzi R.... Ghirlanda G.	2002	INS
20	Erythropoietin response to hypoxia in patients with diabetic autonomic neuropathy and non-diabetic chronic renal failure. (11869305)	Bosman D.R.... Watkins P.J.	2002	EPO
21	Autonomic neuropathies. (12352004)	Low P.A.	2002	EPO
22	Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. (12102460)	Indo Y.	2002	NTRK1
23	A novel TRK A (NTRK1) mutation associated with hereditary sensory and autonomic neuropathy type V. (11310631)	Houlden H.... Thomas P.K.	2001	NTRK1
24	Erythropoietin treatment of postural hypotension in anemic type 1 diabetic patients with autonomic neuropathy: a case study of four patients. (11375382)	Winkler A.S.... Watkins P.J.	2001	EPO
25	Cardiovascular autonomic neuropathy (expiration and i nspiration ratio) in type 1 diabetes. Incidence and predictors. (10925059)	Stella P.... Orchard T.J.	2000	ALB
26	Plasma big-endothelin levels, cardiac autonomic neuropathy, and cardiac functions in patients with insulin-dependent diabetes mellitus. (10763073)	Erbas T.... Gedik O.	2000	INS
27	Cardiovascular autonomic neuropathy in insulin-depend ent diabetes mellitus: prevalence and estimated risk of coronary heart disease in the general population. (11155141)	May O.... Mickley H.	2000	INS
28	Pupil abnormality in amyloidosis with autonomic neuropathy. (10567509)	Davies D.R.... Smith S.E.	1999	TTR
29	Prerenal azotemia in a diabetic patient with hyporeni nemic hypoaldosteronism and autonomic neuropathy. (10566125)	Elisaf M.S.... Siamopoulos K.C.	1999	REN
30	Long-term effect of epalrestat on cardiac autonomic neuropathy in subjects with non-insulin dependent diabetes mellitus. (10369429)	Ikeda T.... Tanaka Y.	1999	AKR1B1
31	Autonomic neuropathies. (9848003)	Low P.A.	1998	EPO
32	Autonomic neuropathy and cardiovascular risk factors in insulin-dependent and non insulin-dependent diabetes. (9069569)	Spallone V.... Menzinger G.	1997	ALB, INS
33	Clinical report of 60 cases of diabetic cardio-vascu lar autonomous neuropathy by stasis removing treatment of combined traditional and Western medicine (10322888)	Huang S.M.... Wu L.F.	1997	TBXAS1
34	Gastrinemia and heparin stimulated secretion of diamine oxidase on the course of diabetic autonomic neuropathy (9296889)	Loba J.... Brozynski K.	1997	ABP1, GAST
35	Autonomic neuropathy with gastropathy and elevated urinary 5-hydroxy indole acetic acid in insulin-dependent diabetes mellitus. (8651206)	Nolan B.... Mitchell T.H.	1996	INS
36	Association of cardiac autonomic neuropathy and microalbuminuria in non-insulin-dependent diabetes mellitus. (15251549)	Wieland R.G.	1996	ALB
37	Plasma met-enkephalin levels in diabetic patients: influence of autonomic neuropathy. (8781292)	Fallucca F.... Negri M.	1996	INS
38	Cholecystokinin and pancreatic polypeptide release in diabetic patients with and without autonomic neuropathy. (7851207)	Glasbrenner B.... Malfertheiner P.	1995	CCK
39	Cardiovascular effects of autonomic neuropathy in insulin-dependent diabetes mellitus (8819738)	Galetta F.... Giusti C.	1995	INS
40	Association of autonomic neuropathies and gastrointestinal peptides in non-insulin dependent diabetics (7739457)	KostiA8 N.... RatkoviA8 M.	1994	INS, GAST
41	Autonomic neuropathy in African diabetic patients. (8183750)	Tuch P.S.... Huddle K.R.	1994	INS
42	An investigation of antibodies to nerve growth factor in diabetic autonomic neuropathy. (8088110)	Zanone M.M.... Watkins P.J.	1994	NGF
43	Effects of autonomic neuropathy on glucose, fatty acid, and ketone body metabolism following insulin withdrawal in patients with insulin-dependent diabetes. (8061346)	Krentz A.J.... Nattrass M.	1994	INS
44	Hereditary Sensory and Autonomic Neuropathy Type II (21089229)	Kurth I.	1993	WNK1, KIF1A, FAM134B
45	Day and night variation in ambulatory blood pressure in type 1 diabetes mellitus with nephropathy and autonomic neuropathy. (8433073)	Torffvit O.... Agardh C.D.	1993	INS
46	Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentration in diabetic autonomic neuropathy. (8503391)	Kawagishi T.... Morii H.	1993	MLN
47	Mechanisms of arterial hypotension after therapeutic dose of subcutaneous insulin in diabetic autonomic neuropathy. (8513972)	Porcellati F.... BRUNETTI P.	1993	INS
48	Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin. (1425065)	Fiorucci S.... Morelli A.	1992	MLN
49	A double-blind crossover study of oral xamoterol in postural hypotension due to diabetic autonomic neuropathy. (1688039)	Leslie P.J.... Ewing D.J.	1991	INS
50	Regulation of ANP secretion in insulin-dependent diabetes mellitus and the influence of autonomic neuropathy. (1839570)	Thompson C.J.... Ewing D.J.	1991	INS, NPPA

Genes related to autonomic neuropathy according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	NGF	nerve growth factor (beta polypeptide)	11.1	Publications, Summaries
2	IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	11.1	Publications, Aliases & Descriptions
3	FAM134B	family with sequence similarity 134, member B	11.1	Publications, Summaries
4	NTRK1	neurotrophic tyrosine kinase, receptor, type 1	11.0	Publications
5	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)	11.0	Publications
6	MLNR	motilin receptor	11.0	Publications
7	MLN	motilin	11.0	Publications
8	GAST	gastrin	11.0	Publications
9	NTF3	neurotrophin 3	11.0	Publications
10	INS	insulin	11.0	Publications
11	EPO	erythropoietin	11.0	Publications
12	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
13	WNK1	WNK lysine deficient protein kinase 1	11.0	Publications
14	NGFR	nerve growth factor receptor	11.0	Publications
15	DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	11.0	Publications
16	NPY	neuropeptide Y	11.0	Publications
17	CCK	cholecystokinin	11.0	Publications
18	TTR	transthyretin	11.0	Publications
19	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	11.0
20	GCG	glucagon	11.0	Publications
21	GAD1	glutamate decarboxylase 1 (brain, 67kDa)	11.0	Publications
22	REN	renin	11.0	Publications
23	ALB	albumin	11.0	Publications
24	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
25	MAP6D1	MAP6 domain containing 1	11.0	Disorders
26	PPY	pancreatic polypeptide	11.0	Publications
27	SPTLC1	serine palmitoyltransferase, long chain base subunit 1	11.0	Publications
28	HCN3	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	11.0
29	PTPRN	protein tyrosine phosphatase, receptor type, N	11.0	Publications
30	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	11.0	Publications
31	KIF1A	kinesin family member 1A	11.0	Publications
32	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	11.0	Publications
33	CCT5	chaperonin containing TCP1, subunit 5 (epsilon)	11.0	Publications
34	RAB7A	RAB7A, member RAS oncogene family	11.0	Publications
35	AGER	advanced glycosylation end product-specific receptor	11.0	Publications
36	TBXAS1	thromboxane A synthase 1 (platelet)	11.0	Publications
37	PTPN3	protein tyrosine phosphatase, non-receptor type 3	11.0	Publications
38	HBA1	hemoglobin, alpha 1	11.0
39	HBA2	hemoglobin, alpha 2	11.0
40	NPPA	natriuretic peptide A	11.0	Publications
41	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
42	DST	dystonin	9.3	Publications

Pathways related to autonomic neuropathy according to GeneDecks:

(show all 24)

id	Pathway	Score	Top Affiliating Genes
1	Beta-alanine metabolism10	10.4	ABP1, GAD1, GAD2
2	Beta-alanine metabolism41	10.4	ABP1, GAD1, GAD2
3	GABA synthesis38	10.4	GAD2, GAD1
4	Development MAG-dependent inhibition of neurite outgrowth10	10.4	NGFR, NGF, NTRK1, NTF3
5	Development_Neurotrophin family signaling41	10.4	NGFR, NGF, NTRK1, NTF3
6	Development Neurotrophin family signaling10	10.3	NGFR, NGF, NTRK1, NTF3
7	Development_MAG-dependent inhibition of neurite outgrowth41	10.3	NGFR, NGF, NTRK1, NTF3
8	G alpha (q) signalling events38	10.2	MLN, MLNR, CCK, GAST
9	Selected targets of CREB110	10.1	CCK, INS, GCG, REN
10	Type I diabetes mellitus20	10.1	GAD2, GAD1, PTPRN, INS
11	Neuroscience3	10.0	GAD2, GAD1, DBH, NGFR, NGF, NTRK1
12	Apoptotic Pathways in Synovial Fibroblasts36	9.4	NGFR, NTRK1, NTF3, IGF1, IL2RA
13	eIF2 Pathway36	9.3	NGFR, NTRK1, NTF3, IGF1, IL2RA, INS
14	p53 Mediated Apoptosis36	9.3	IL2RA, IGF1, NTF3, NTRK1, NGFR
15	Telomerase Components in Cell Signaling36	9.3	NGFR, NTRK1, NTF3, IGF1, IL2RA
16	p70S6K Signaling36	9.3	NGFR, NTRK1, NTF3, IGF1, IL2RA, INS
17	Mitochondrial Apoptosis36	9.2	NGFR, NTRK1, NTF3, IGF1, IL2RA
18	Metabolism of lipids and lipoproteins38	9.2	SPTLC3, SPTLC1, SPTLC2, TBXAS1, AKR1B1, ALB
19	Renin-Angiotensin Pathway36	9.2	NGFR, NTRK1, NTF3, IGF1, IL2RA, REN
20	DHA Signaling36	9.2	NGFR, NTRK1, NTF3, IGF1, IL2RA
21	PPAR Pathway36	9.1	IL2RA, IGF1, NTF3, NTRK1, NGFR
22	ERK5 Signaling36	9.0	NGFR, NTRK1, NTF3, IGF1, IL2RA
23	Cellular Apoptosis Pathway36	8.8	NGFR, NTRK1, NTF3, IGF1, IL2RA
24	cAMP Pathway36	8.5	NGFR, NTRK1, NTF3, PTPN3, IGF1, IL2RA

Compounds related to autonomic neuropathy according to GeneDecks:

(show top 50)    (show all 192)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.3	GCG, PTPRN, NTF3, GAST
2	bethanechol32 9 9	12.2	GCG, MLN, CCK, GAST, NPY
3	carbachol32 9 9	12.2	CCK, GAST, GCG
4	oxyntomodulin32 42	11.1	GAST, NPY, CCK, MLN, GCG
5	gnrh32	10.0	GCG, DBH, NTRK1, NPY, IGF1, INS
6	atropine32 9 9	12.0	NPY, GAST, NGF, CCK, MLN, GCG
7	levodopa32 9 9	11.8	GAD1, DBH, NGF, AKR1B1, IGF1, GAD2
8	vitamin b1232	9.8	IGF1, GAST, AKR1B1, EPO, ALB, TTR
9	tetrodotoxin32	9.8	NPY, GAD2, CCK, MLN, GCG, GAD1
10	choline32 9 18 9	12.8	GAD1, NTF3, DBH, NGF, NTRK1, NGFR
11	octreotide32 42 9 9	12.8	INS, CCK, IGF1, NPY, EPO, GAST
12	streptozotocin32	9.7	INS, AKR1B1, GCG, NPY, AGER, NTF3
13	acth32	9.7	CCK, DBH, NPY, GAST, IGF1, INS
14	c-peptide32	9.6	GAD2, GCG, CCK, PTPN3, PTPRN, GAD1
15	metoclopramide32 9 9	11.6	REN, MLN, CCK, DBH, NPPA
16	5-hydroxytryptamine32	9.6	GAST, NPY, GCG, MLN, CCK, ABP1
17	thyroxine32 18	10.6	TTR, NGF, NPY, ALB, GAST, IGF1
18	gaba32 42	10.5	GCG, CCK, GAD1, GAST, NTF3, NGFR
19	vitamin b632	9.4	EPO, TTR, NTF3, ALB, GAD1
20	lactate32	9.4	ABP1, TTR, DBH, NPY, EPO, NTRK1
21	catecholamine32	9.3	NPPA, REN, NTF3, NTRK1, DBH, NPY
22	glutamine32	9.3	AKR1B1, GCG, CCK, IGF1, NGF, ABP1
23	glutamate32	9.3	NTF3, GAD1, NTRK1, GCG, INS, PTPN3
24	testosterone32 9 18 9	12.2	GAST, CCK, IL2RA, NTRK1, AKR1B1, NGF
25	wortmannin32 42	10.2	PTPN3, INS, GCG, NTF3, NTRK1, NGFR
26	cysteine32	9.1	PTPN3, GAD2, GCG, ALB, NTF3, GAD1
27	heparin32 9 18 9	11.8	MLN, ALB, NTF3, ABP1, AGER, PTPN3
28	indomethacin32 9 9	10.6	NGFR, NGF, AKR1B1, ALB, GCG, REN
29	forskolin32 42 9 9	11.6	CCK, REN, GCG, PTPN3, NGF, NGFR
30	histamine32 18	9.6	NGFR, ABP1, DBH, NPY, GAST, ALB
31	phosphatidylinositol32	8.4	RAB7A, WNK1, NGFR, NTF3, IL2RA, NGF
32	nifedipine32 9 9	10.3	NGF, GAST, NPY, REN, GCG, MLN
33	alanine32	8.3	TTR, DBH, NPY, GAD2, GAST, HBA2
34	epinephrine32 9 18 9	11.2	GAST, NPY, NPPA, DBH, TTR, NGF
35	genistein32 9 18 9	11.2	IGF1, TTR, PTPN3, NGF, GCG, IL2RA
36	cyclosporin a32 42	9.1	EPO, NGF, PTPRN, AKR1B1, TTR, NPPA
37	acetylcholine32 9 18 9	11.1	NGF, NTRK1, NTF3, CCK, IL2RA, GCG
38	calcium32 9 18 9	11.1	MLN, NTRK1, ABP1, NTF3, AGER, PTPN3
39	nitric oxide32 9 18 9	11.0	REN, MLN, PTPN3, NTF3, NTRK1, NGFR
40	norepinephrine32 9 18 9	11.0	DBH, NTF3, REN, GCG, INS, IL2RA
41	serine32	7.9	GAST, WNK1, GCG, DBH, TTR, AGER
42	cholesterol32 9 18 9	10.9	REN, NGFR, IGF1, ALB, PTPN3, SPTLC1
43	creatinine32	7.8	REN, GCG, IL2RA, IGF1, AGER, NPY
44	adenylate32	7.8	NPY, GAST, MLN, DBH, TTR, HBA2
45	estrogen32	7.5	INS, GCG, NPY, NPPA, NGFR, TTR
46	arginine32	7.4	REN, NPPA, PTPRN, NPY, MLN, GAD1
47	dopamine32 9 18 9	10.4	GAD2, NTRK1, NTF3, CCK, IL2RA, MLNR
48	vegf32	7.4	NGF, EPO, AKR1B1, IGF1, IL2RA, GCG
49	oxygen32 18	8.4	DBH, AKR1B1, PTPN3, TBXAS1, NTF3, ABP1
50	tyrosine32	6.5	DBH, MLN, WNK1, NPY, AGER, HBA2

Cellular components related to autonomic neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	serine C-palmitoyltransferase complex	GO:017059	9.7	SPTLC2, SPTLC1, SPTLC3
2	extracellular space	GO:005615	8.4	EPO, NPY, TTR, ABP1, NGF, AKR1B1
3	extracellular region	GO:005576	7.3	GCG, GAST, EPO, NPY, NPPA, DBH

Biological processes related to autonomic neuropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sphinganine biosynthetic process	GO:046511	10.0	SPTLC2, SPTLC1
2	positive regulation of Ras protein signal transduction	GO:046579	10.0	IGF1, NTRK1, EPO
3	glutamate decarboxylation to succinate	GO:006540	9.8	GAD1, GAD2

Molecular functions related to autonomic neuropathy according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate decarboxylase activity	GO:004351	10.1	GAD1, GAD2
2	nerve growth factor binding	GO:048406	10.1	NTF3, NTRK1, NGFR
3	serine C-palmitoyltransferase activity	GO:004758	9.8	SPTLC3, SPTLC1, SPTLC2
4	insulin-like growth factor receptor binding	GO:005159	9.7	REN, INS, IGF1
5	pyridoxal phosphate binding	GO:030170	9.3	GAD2, GAD1, SPTLC3, SPTLC1, SPTLC2, ALB
6	receptor binding	GO:005102	8.8	NPY, NPPA, PPY, NTF3, MLN, GCG
7	hormone activity	GO:005179	8.7	GCG, GAST, EPO, NPPA, TTR, PPY