JP
MCID: ATS021
MIFTS: 30

Autosomal Recessive Juvenile Parkinson Disease (JP) malady

Ear diseases category

Summaries for Autosomal Recessive Juvenile Parkinson Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Parkin is a protein which in humans is encoded by the PARK2 gene. The precise function of this protein... more...

MalaCards: Autosomal Recessive Juvenile Parkinson Disease, also known as parkinson disease 2, is related to parkinson's disease and lafora disease. An important gene associated with Autosomal Recessive Juvenile Parkinson Disease is PACRG (PARK2 co-regulated), and among its related pathways are TGF-Beta Pathway and Cell Cycle. The compound geldanamycin have been mentioned in the context of this disorder.

Aliases & Classifications for Autosomal Recessive Juvenile Parkinson Disease

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Sources:
42NIH Rare Diseases, 22GTR, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Ear diseases


Aliases & Descriptions:

autosomal recessive juvenile parkinson disease 42 60
parkinson disease 2 42 22
parkinson disease autosomal recessive, early onset 42
juvenile parkinsonism 42
park2 42
jp 42


Related Diseases for Autosomal Recessive Juvenile Parkinson Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Parkinson Disease 15, Autosomal Recessive family:

autosomal recessive juvenile parkinson disease Parkinson Disease 7, Autosomal Recessive Early-Onset

Diseases related to Autosomal Recessive Juvenile Parkinson Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease30.5PARK2, PACRG, UBC
2lafora disease30.2PARK2
3progressive myoclonus epilepsy30.1PARK2
4fanconi's anemia30.1PARK2
5herpes simplex30.1PARK2
6papilloma30.1PARK2, TP53
7dementia29.9PARK2
8juvenile polyposis syndrome10.4
9leprosy10.4
10neuronitis10.3
11parkinson disease, juvenile, type 210.3
12autosomal recessive disease10.2
13juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome10.2
14bell's palsy10.1
15thanatophoric dysplasia10.1
16essential tremor10.1
17adenocarcinoma10.1
18leukemia10.1
19lymphoblastic leukemia10.1
20limb-girdle muscular dystrophy type 2h10.1
21classic rett syndrome10.1
22hypersomnia10.1
23tremor10.1
24pathological gambling10.1
25pulmonary tuberculosis10.1
26angelman syndrome10.1
27bardet-biedl syndrome10.1
28alzheimer's disease10.1
29chronic myeloid leukemia10.1
30adenoma10.1
31arthritis10.1
32autism spectrum disorder10.1
33breast cancer10.1
34hepatocellular carcinoma10.1
35lung adenocarcinoma10.1
36multiple system atrophy10.1
37myeloid leukemia10.1
38obesity10.1
39renal cell carcinoma10.1
40retinoblastoma10.1
41rheumatoid arthritis10.1
42tuberculosis10.1
43parkin type of early-onset parkinson disease10.1
44myoclonus epilepsy10.1
45mental retardation10.1
46myoclonus10.1
47prokr2-related isolated gonadotropin-releasing hormone deficiency10.0
48vps35-related parkinson disease10.0
49rett syndrome10.0
50machado-joseph disease10.0

Graphical network of the top 20 diseases related to Autosomal Recessive Juvenile Parkinson Disease:



Diseases related to autosomal recessive juvenile parkinson disease

Clinical Features for Autosomal Recessive Juvenile Parkinson Disease

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Drugs & Therapeutics for Autosomal Recessive Juvenile Parkinson Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Autosomal Recessive Juvenile Parkinson Disease

Drug clinical trials:

Search ClinicalTrials for Autosomal Recessive Juvenile Parkinson Disease

Search NIH Clinical Center for Autosomal Recessive Juvenile Parkinson Disease

Search CenterWatch for Autosomal Recessive Juvenile Parkinson Disease

Genetic Tests for Autosomal Recessive Juvenile Parkinson Disease

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22GTR
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Genetic tests related to Autosomal Recessive Juvenile Parkinson Disease:

id Genetic test Affiliating Genes
1 Parkinson Disease 222

Anatomical Context for Autosomal Recessive Juvenile Parkinson Disease

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Animal Models for Autosomal Recessive Juvenile Parkinson Disease or affiliated genes

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Publications for Autosomal Recessive Juvenile Parkinson Disease

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Genetic Variations for Autosomal Recessive Juvenile Parkinson Disease

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Expression for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

Search GEO for disease gene expression data for Autosomal Recessive Juvenile Parkinson Disease.

Pathways for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Autosomal Recessive Juvenile Parkinson Disease according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7PSMD4
2
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9.7PSMD4
39.5SYT11, PARK2
49.5PARK2, UBC
59.3UBC, TP53
69.3UBC, TP53
7
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9.3UBC, TP53
89.3UBC, TP53
99.3UBC, TP53
109.3TP53, UBC
11
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9.2PARK2, PSMD4
12
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8.7UBC, PARK2, PSMD4
138.5TP53, PSMD4, UBC
14
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8.5TP53, UBC, PSMD4
15
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8.2UBC, PSMD4, SYT11, PARK2

Compounds for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Autosomal Recessive Juvenile Parkinson Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1geldanamycin44 49 59 1112.4TP53, PARK2

GO Terms for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

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Sources:
16Gene Ontology
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Biological processes related to Autosomal Recessive Juvenile Parkinson Disease according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.6TP53, UBC
2negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514369.3PSMD4, UBC
3positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514379.3PSMD4, UBC
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentGO:0024799.2PSMD4, UBC
5regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleGO:0514399.2PSMD4, UBC
6antigen processing and presentation of exogenous peptide antigen via MHC class IGO:0425909.1UBC, PSMD4
7antigen processing and presentation of peptide antigen via MHC class IGO:0024749.1PSMD4, UBC
8anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:0311459.0PSMD4, UBC
9cellular response to hypoxiaGO:0714569.0TP53, UBC
10protein polyubiquitinationGO:0002098.9PARK2, PSMD4, UBC
11DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069778.8TP53, PSMD4, UBC
12regulation of apoptotic processGO:0429818.7UBC, PSMD4, TP53
13negative regulation of apoptotic processGO:0430668.7UBC, PSMD4, TP53

Molecular functions related to Autosomal Recessive Juvenile Parkinson Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chaperone bindingGO:0510879.3TP53, PARK2
2protease bindingGO:0020209.0TP53, UBC
3identical protein bindingGO:0428028.6TP53, PARK2, PSMD4

Products for genes affiliated with Autosomal Recessive Juvenile Parkinson Disease

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  • Antibodies
  • Proteins
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Sources for Autosomal Recessive Juvenile Parkinson Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet