MCID: AVS004
MIFTS: 56

Avascular Necrosis of the Femoral Head malady

Categories: Genetic diseases, Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis of the Femoral Head

About this section

Aliases & Descriptions for Avascular Necrosis of the Femoral Head:

Name: Avascular Necrosis of the Femoral Head 51 34 12
Avascular Necrosis of Femoral Head, Primary 51 24
Femur Head Necrosis 38 67
Anfh 24 69
Avascular Necrosis of the Femoral Head, Primary 69
Familial Avascular Necrosis of Femoral Head 53
 
Familial Osteonecrosis of the Femoral Head 53
Avascular Necrosis of Femoral Head 69
Ischemic Necrosis of Femoral Head 69
Aseptic Necrosis of Femoral Head 69
Avascular Necrosis of Femur Head 67
Osteonecrosis of Femoral Head 69

Characteristics:

Orphanet epidemiological data:

53
familial avascular necrosis of femoral head:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (United States); Age of onset: Adult

HPO:

63
avascular necrosis of the femoral head:
Inheritance: autosomal dominant inheritance

Classifications:

Orphanet: 53 
Rare bone diseases


External Ids:

OMIM51 608805
Orphanet53 ORPHA86820
ICD10 via Orphanet30 M87.8
MedGen36 C0410480
MeSH38 D005271

Summaries for Avascular Necrosis of the Femoral Head

About this section
UniProtKB/Swiss-Prot:69 Avascular necrosis of the femoral head, primary: A disease characterized by mechanical failure of the subchondral bone, and degeneration of the hip joint. It usually leads to destruction of the hip joint in the third to fifth decade of life. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability.

MalaCards based summary: Avascular Necrosis of the Femoral Head, also known as avascular necrosis of femoral head, primary, is related to legg-calve-perthes disease and familial avascular necrosis of the femoral head, and has symptoms including avascular necrosis of the capital femoral epiphysis An important gene associated with Avascular Necrosis of the Femoral Head is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways are Oxidative Stress and Detoxification of Reactive Oxygen Species. Affiliated tissues include bone, bone marrow and endothelial, and related mouse phenotypes are cardiovascular system and vision/eye.

Description from OMIM:51 608805

Related Diseases for Avascular Necrosis of the Femoral Head

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Diseases in the Avascular Necrosis of the Femoral Head family:

Familial Avascular Necrosis of the Femoral Head

Diseases related to Avascular Necrosis of the Femoral Head via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1legg-calve-perthes disease25.4ABCB1, APOA1, APOB, CAT, COL2A1, HLA-DRB1
2familial avascular necrosis of the femoral head12.4
3sickle cell disease10.5
4osteonecrosis10.4
5traumatic avascular necrosis10.4
6vagina leiomyoma10.4IGFBP3, SOD1
7idiopathic progressive polyneuropathy10.3LEP, SOD1
8multiple system atrophy with orthostatic hypotension10.3CAT, SOD1
9potato nose10.3HLA-DRB1, LEP
10leukemia10.3
11endotheliitis10.3
12pseudoretinitis pigmentosa10.2CAT, SOD1
13transient neonatal thrombocytopenia10.2CAT, SOD1
14systemic lupus erythematosus10.2
15arthritis10.2
16lupus erythematosus10.2
17idiopathic avascular necrosis10.2
18retinitis pigmentosa10.2CAT, SOD1
19hordeolum externum10.1HLA-DRB1, LEP
20osteoarthritis10.1
21bursitis10.1
22slipped capital femoral epiphysis10.1
23ovarian insufficiency, familial10.1ABCB1, COL2A1
24isodicentric 1510.1CAT, SOD1
25rheumatoid arthritis10.1
26prostate cancer10.1
27lymphoma10.1
28lymphoblastic leukemia10.1
29prostatitis10.1
30periostitis10.1
31back pain10.1
32shwachman-diamond type metaphyseal dysplasia10.0APOA1, APOB
33polyneuropathy10.0APOA1, APOB
34rubinstein taybi like syndrome10.0APOA1, APOB
35islet cell tumor10.0APOA1, APOB
36bladder diverticulum10.0APOA1, APOB
37inflamed seborrheic keratosis10.0APOA1, APOB
38chondrocalcinosis with early-onset osteoarthritis9.9APOA1, APOB
39neuroblastoma9.9
40hiv-19.9
41trichorhinophalangeal syndrome, type i9.9
42metachondromatosis9.9
43acute leukemia9.9
44cerebral palsy9.9
45male infertility9.9
46spinal stenosis9.9
47osteomalacia9.9
48brucellosis9.9
49sarcoma9.9
50pituitary apoplexy9.9

Graphical network of the top 20 diseases related to Avascular Necrosis of the Femoral Head:



Diseases related to avascular necrosis of the femoral head

Symptoms for Avascular Necrosis of the Femoral Head

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Clinical features from OMIM:

608805

Human phenotypes related to Avascular Necrosis of the Femoral Head:

 63
id Description HPO Frequency HPO Source Accession
1 avascular necrosis of the capital femoral epiphysis63 HP:0005743

Drugs & Therapeutics for Avascular Necrosis of the Femoral Head

About this section

Drugs for Avascular Necrosis of the Femoral Head (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 98)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AlendronateapprovedPhase 4160121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
2
MethyclothiazideapprovedPhase 45135-07-94121
Synonyms:
(+-)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
135-07-9
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-,1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxid
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1
AC1L1HGJ
AC1Q6TPS
AR-1J4220
Aquaresen
Aquatensen
BRN 0765361
C07765
C9H11Cl2N3O4S2
CHEMBL1577
CI-625
CID4121
Ciba 7272-Su
D00656
DB00232
Duretic
EINECS 205-172-2
Enduron
Enduron (TN)
Enduronum
 
HSDB 3363
I06-1878
LS-40433
METHYLCLOTHIAZIDE
MLS002704228
Methychlothiazide
Methyclothiazid
Methyclothiazide (JAN/USP/INN)
Methyclothiazide [USAN:INN:BAN:JAN]
Methyclothiazidum
Methyclothiazidum [INN-Latin]
Methycyclothiazide
Methylchlorothiazide
Methylclothiazide
Methylcyclothiazide
Meticlotiazida
Meticlotiazida [INN-Spanish]
Meticlotiazide
Meticlotiazide [DCIT]
NCGC00167446-01
NSC 110431
NSC-110431
NSC110431
Naturon
Naturon (VAN)
SBB070984
SMR001550236
UNII-L3H46UAC61
WLN: T66 BSWN EM DHJ C1 D1G HG ISZW
e
methyclothiazide
3
Etidronic acidapprovedPhase 4827414-83-7, 2809-21-43305
Synonyms:
(1-Hydroxyethylene)diphosphonic acid
(1-Hydroxyethylidene)bis(phosphonic acid)
(1-Hydroxyethylidene)bisphosphonic acid
(1-Hydroxyethylidene)diphoshonic acid
(1-Hydroxyethylidene)diphosphonic acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
(1-hydroxy-ethylidene)diphosphonic acid
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
(Hydroxyethylidene)diphosphonic acid
0-02-00-00171 (Beilstein Handbook Reference)
1,1,1-Ethanetriol diphosphonate
1-HYDROXY-1,1-DIPHOSPHONOETHANE
1-Hydroxy-1,1-diphosphonoethane
1-Hydroxyethane-1,1,-diphosphonic acid
1-Hydroxyethane-1,1-bisphosphonic acid
1-Hydroxyethane-1,1-diphosphonate
1-Hydroxyethane-1,1-diphosphonic acid
1-Hydroxyethanediphosphonic acid
1-Hydroxyethylidene 1,1-diphosphonic acid
1-Hydroxyethylidene-1,1-biphosphonate
1-Hydroxyethylidene-1,1-bisphosphonate
1-Hydroxyethylidene-1,1-diphosphonic acid
1-Hydroxyethylidenediphosphonic acid
1-hydroxyethane 1,1-diphosphonic acid
1000SL
100511-44-2
103736-66-9
106908-76-3
129130-42-3
138360-84-6
14860-53-8 (tetra-potassium salt)
192526-55-9
2809-21-4
303177-33-5
51888-66-5
54342_ALDRICH
54342_FLUKA
66216-98-6
853028-38-3
85985-26-8
86159-18-4
AC1L1FMT
Acetodiphosphonic acid
Acide etidronique
Acide etidronique [INN-French]
Acido etidronico
Acido etidronico [INN-Spanish]
Acidum etidronicum
Acidum etidronicum [INN-Latin]
BPBio1_000997
BRN 1789291
BSPBio_000905
Bio-0708
C07736
CHEBI:170675
CHEBI:4907
CHEMBL871
CID3305
 
Cintichem Technetium 99m Hedspa
D02373
DB01077
Dequest 2010
Dequest 2015
Dequest Z 010
Didronel
Didronel IV
Diphosphonate (base)
EHDP
EINECS 220-552-8
Ethane-1-hydroxy-1,1-bisphosphonate
Ethane-1-hydroxy-1,1-bisphosphonic acid
Ethane-1-hydroxy-1,1-diphosphonate
Ethane-1-hydroxy-1,1-diphosphonic acid
Etidronate
Etidronate Disodium
Etidronic acid
Etidronic acid (USAN/INN)
Etidronic acid [USAN:INN:BAN]
Etidronic acid monohydrate
Etidronsaeure
Etidronsäure
Ferrofos 510
H0587
H6773_ALDRICH
H6773_SIGMA
HEDP
HSDB 5898
Hydroxyethane-1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
I14-1271
Jsp005415
LS-106637
MLS002207267
MLS002695948
MPI Stannous Diphosphonate
MolPort-001-786-542
NCGC00159352-02
NSC 227995
NSC227995
Osteoscan
Oxyethylidenediphosphonic acid
Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
Prestwick0_000863
Prestwick1_000863
Prestwick2_000863
Prestwick3_000863
RP 61
SMR000038750
SPBio_002826
STK721995
Turpinal SL
UNII-M2F465ROXU
acide étidronique
acidum etidronicum
ethane-1-hydroxy-1,1-bisphosphonic acid
etidronate
ácido etidrónico
4
Heparinapproved, investigationalPhase 48129005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
5
DalteparinapprovedPhase 43039041-08-1
Synonyms:
Daltepariininatrium
Dalteparin Sodyum
Dalteparin sodium
Dalteparin sodná sůl
Dalteparin-nátrium
Dalteparina sódica
 
Dalteparinnatrium
Dalteparino natrio druska
Dalteparinum Natricum
Dalteparyna sodowa
Daltéparine sodique
Heparin Fragment KABI 2165
Tedelparin
6
RivaroxabanapprovedPhase 4244366789-02-8
Synonyms:
BAY 59-7939
 
BAY59-7939
Xarelto
7AnestheticsPhase 4, Phase 3, Phase 2, Early Phase 19001
8Calcium, DietaryPhase 4, Phase 3, Phase 25525
9Bone Density Conservation AgentsPhase 4, Phase 3, Phase 23266
10diureticsPhase 41372
11Natriuretic AgentsPhase 41645
12Sodium Chloride Symporter InhibitorsPhase 4446
13Serine Proteinase InhibitorsPhase 4850
14Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 212767
15HormonesPhase 4, Phase 213979
16glucocorticoidsPhase 44920
17Hormone AntagonistsPhase 4, Phase 212778
18calcium heparinPhase 4812
19AntithrombinsPhase 4672
20Antithrombin IIIPhase 4665
21AnticoagulantsPhase 42516
22Factor Xa InhibitorsPhase 4391
23Heparin, Low-Molecular-WeightPhase 4320
24
protease inhibitorsPhase 45320
Synonyms:
 
protease inhibitors
25HIV Protease InhibitorsPhase 45319
26Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 41956
27Lipid Regulating AgentsPhase 42702
28Hypolipidemic AgentsPhase 42721
29Atorvastatin CalciumPhase 4743134523-03-8
30Anticholesteremic AgentsPhase 41983
31AntimetabolitesPhase 411774
32serineNutraceuticalPhase 4921
33
Zoledronic acidapprovedPhase 3, Phase 2290118072-93-868740
Synonyms:
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
(1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate
(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
118072-93-8
2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
AC-1092
AC1L2ACJ
AC1Q6RN3
AKOS005145739
Aclasta
Anhydrous Zoledronic Acid
BIDD:GT0292
BIDD:PXR0134
Bio-0112
Bisphosphonate 3
C088658
CGP 42'446
CGP 42446
CGP 42446A
CGP-42'446
CGP-42446
CHEBI:46557
CHEMBL924
CID68740
D08689
DB00399
 
FT-0082657
HMS2089O09
I06-0710
KS-1132
LS-181815
MolPort-002-885-874
MolPort-003-850-890
NCGC00159521-02
NCGC00159521-03
NSC721517
Novartis brand of zoledronic acid
Reclast
Reclast (TN)
S00092
S1314_Selleck
UNII-70HZ18PH24
ZOL
Zol
Zoledronate
Zoledronic Acid Anhydrous
Zoledronic Acid, Anhydrous
Zoledronic acid
Zoledronic acid (INN)
Zoledronic acid [USAN:INN]
Zometa
Zometa (Novartis)
Zometa (TN)
Zometa Concentrate
Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
34
DonepezilapprovedPhase 3280120014-06-43152
Synonyms:
( inverted exclamation markA)-E 2020
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
120014-06-4
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
AB1004836
AC-6969
AC1L1FAE
AKOS000277311
Aricept
Aricept ODT
C24H29NO3
CHEBI:53289
CHEMBL502
CID3152
D07869
DB00843
Domepezil
Donaz
Donaz (TN)
 
Donepezil
Donepezil (INN)
Donepezil [INN:BAN]
Donepezil hydrochloride
Donepezilo
Donepezilum
Eranz
I06-0343
KBio2_002144
KBio2_004712
KBio2_007280
KBioSS_002144
LS-81819
MolPort-000-881-588
MolPort-003-847-014
NCGC00167537-01
Oprea1_188452
Spectrum5_001662
Spectrum_001664
TL8000531
UNII-8SSC91326P
35Cholinergic AgentsPhase 33846
36DiphosphonatesPhase 3, Phase 2446
37Neurotransmitter AgentsPhase 317734
38Ibandronic acidPhase 380
39Fibrin Tissue AdhesivePhase 3145
40vitamin dPhase 31653
41HemostaticsPhase 31359
42CoagulantsPhase 31428
43Cholinesterase InhibitorsPhase 3570
44Nootropic AgentsPhase 3701
45
Miconazoleapproved, investigational, vet_approvedPhase 2362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
46
Ketoconazoleapproved, investigationalPhase 217465277-42-147576, 3823
Synonyms:
(+)-Ketoconazole
(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1- ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
(+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
65277-42-1
79156-75-5
AC-15957
AC1L9UG3
BIDD:GT0696
BIM-0050645.0001
BPBio1_000635
BRD-K29113274-001-03-6
BRN 4303081
BSPBio_000577
C26H28Cl2N4O4
CHEBI:48336
CHEMBL75
CID456201
CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE
CPD000058460
EINECS 265-667-4
EU-0100666
Extina
Fungarest
Fungoral
HMS1569M19
HMS2051A19
HMS2089N05
HSDB 7447
K 1003
K0045
K1003_SIGMA
KCZ
KS-1205
KTZ
KW-1414
KZ
Ketoconazol
Ketoconazole
Ketoconazole [USAN:INN:BAN:JAN]
Ketoconazolum
Ketoderm
Ketoisdin
Ketozole
 
LS-110149
Lopac0_000666
MLS000069784
MLS000758224
MLS001146934
MLS002207053
MLS002222255
MolPort-003-848-307
NCGC00025000-01
NCGC00025000-02
NCGC00025000-03
NCGC00025000-04
NCGC00025000-05
NCGC00025000-06
NCGC00025000-07
NCGC00025000-08
NCGC00025000-09
NSC 317629
NSC317629
Nizoral
Nizoral a-D
Nizoral, Extina, Xolegel, Kuric, Ketoconazole
Orifungal M
Panfungol
Piperazine
Prestwick0_000389
Prestwick1_000389
Prestwick2_000389
Prestwick3_000389
Prestwick_744
R 41,400
R 41400
R-41400
R41,400
R41400
S1353_Selleck
SAM001246983
SMR000058460
SPBio_002498
Tocris-1103
UC280_SIGMA
UPCMLD-DP138
UPCMLD-DP138:001
Xolegel
cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H- imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-ketoconazol
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine
ketoconazole
47Cytochrome P-450 CYP3A InhibitorsPhase 21666
48Antifungal AgentsPhase 23615
49Steroid Synthesis InhibitorsPhase 21718
50Anti-Infective AgentsPhase 221402

Interventional clinical trials:

(show top 50)    (show all 90)
idNameStatusNCT IDPhase
1Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic OsteonecrosisUnknown statusNCT00265252Phase 4
2A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip ReplacementUnknown statusNCT00208442Phase 4
3Benefit of Orthopedic Navigation in the ARThroplasty of the HipCompletedNCT01496300Phase 4
4Prophylaxis of Deep Vein Thrombosis Following Total Hip ArthroplastyCompletedNCT02379663Phase 4
5Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years OldCompletedNCT02338596Phase 4
6Vertebral Fracture and Osteonecrosis Associated With High-dose GlucocorticoidCompletedNCT00679978Phase 4
7Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMIRecruitingNCT02590653Phase 4
8Efficacy of the CLP® Hip - RetrospectiveTerminatedNCT00764842Phase 4
9Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip ReplacementTerminatedNCT00872547Phase 4
10Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH)Unknown statusNCT01613612Phase 2, Phase 3
11Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected SubjectsUnknown statusNCT00172315Phase 3
12Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral HeadCompletedNCT00939900Phase 3
13Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip ReplacementCompletedNCT00161902Phase 3
14Project JAY THA Registration StudyCompletedNCT02347384Phase 3
15Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled TrialCompletedNCT00532220Phase 3
16Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral HeadRecruitingNCT01892514Phase 3
17Phase 3 Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral HeadRecruitingNCT01529008Phase 3
18Trinity™ BIOLOX Delta™ CoC THR Multi-center StudyActive, not recruitingNCT01921309Phase 3
19A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in ChinaActive, not recruitingNCT02399007Phase 3
20Donepezil Attenuate Postoperative Cognitive DysfunctionNot yet recruitingNCT02927522Phase 3
21A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
22MBCP Safety and Performance in the Osteonecrosis of Femur HeadUnknown statusNCT00289575Phase 2
23PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem CellsUnknown statusNCT01700920Phase 2
24Osteonecrosis of the Hip and Bisphosphonate TreatmentUnknown statusNCT00781261Phase 2
25Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee SurgeryCompletedNCT00393848Phase 2
26Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral HeadCompletedNCT01643655Phase 1, Phase 2
27Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral HeadCompletedNCT02890537Phase 2
28Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral HeadCompletedNCT00505219Phase 2
29Evaluation of Mesenchymal Stem Cells to Treat Avascular Necrosis of the HipRecruitingNCT02065167Phase 2
30Mesenchymal Stem Cells in Osteonecrosis of the Femoral HeadRecruitingNCT01605383Phase 1, Phase 2
31Autologous Bone Marrow Stem Cell Transplantation for Hip Osteonecrosis in Sickle Cell DiseaseEnrolling by invitationNCT02448121Phase 1, Phase 2
32Treatment of Osteonecrosis of the Femoral Head by Bone Marrow TransplantationCompletedNCT00821470Phase 1
33Evaluate the Effect of Bone Marrow Derived Cd133+ Cells in Patient With Osteonecrosis of Femoral HeadCompletedNCT01198080Phase 1
34Molecular Genetic Study of Avascular Necrosis of the Femoral HeadUnknown statusNCT00260897
35Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadUnknown statusNCT00813267Early Phase 1
36Comparison of Hip Resurfacing to Large Femoral Head Total Hip ArthroplastyUnknown statusNCT00175487
37Ketamine Prevent POCDUnknown statusNCT02220400
38Acetylcholine and Postoperative Cognitive Change in Aged PatientsUnknown statusNCT02063542
39A Comparison of Two Different Surgical Techniques in Hip Resurfacing ArthroplastyUnknown statusNCT00913679
40Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head NecrosisCompletedNCT00244400
41Transcription Factor Runx2 in Necrotic Femoral Head TissueCompletedNCT02735538
42Clinical and Radiological Results of Total Hip Arthroplasty Using a Ceramic Friction PairCompletedNCT02062437
43The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral HeadCompletedNCT02007915
44Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular CupCompletedNCT02062450
45Rotational Thromboelastography Study in Tranexamic Acid and Colloid InfusionCompletedNCT02146456
46The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
47Controlled Study of Stage 3 Osteonecrosis Treatment by Bone MarrowCompletedNCT01544712
48Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityCompletedNCT02087436
49A Clinical Investigation of the C2a-Taper™ Acetabular SystemCompletedNCT00578851
50Selective Ultrasound Screening for DDH 1991-2006CompletedNCT01866527

Search NIH Clinical Center for Avascular Necrosis of the Femoral Head

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Avascular Necrosis of the Femoral Head:
RNL-Astrostem
Embryonic/Adult Cultured Cells Related to Avascular Necrosis of the Femoral Head:
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080


Cochrane evidence based reviews: femur head necrosis

Genetic Tests for Avascular Necrosis of the Femoral Head

About this section

Genetic tests related to Avascular Necrosis of the Femoral Head:

id Genetic test Affiliating Genes
1 Avascular Necrosis of Femoral Head, Primary24 COL2A1

Anatomical Context for Avascular Necrosis of the Femoral Head

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MalaCards organs/tissues related to Avascular Necrosis of the Femoral Head:

35
Bone, Bone marrow, Endothelial, Heart, Myeloid, Prostate, Pituitary

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Avascular Necrosis of the Femoral Head:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Avascular Necrosis of the Femoral Head or affiliated genes

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MGI Mouse Phenotypes related to Avascular Necrosis of the Femoral Head:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7ABCB1, APOA1, APOB, COL2A1, LEP, SOD1
2MP:00053917.9APOB, COL2A1, LEP, SOD1, SREBF2
3MP:00053707.4ABCB1, APOA1, APOB, COL2A1, IGFBP3, LEP
4MP:00053766.9ABCB1, APOA1, APOB, CAT, COL2A1, IGFBP3

Publications for Avascular Necrosis of the Femoral Head

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Articles related to Avascular Necrosis of the Femoral Head:

(show top 50)    (show all 365)
idTitleAuthorsYear
1
Effects of Focused Extracorporeal Shock Waves on Bone Marrow Mesenchymal Stem Cells in Patients with Avascular Necrosis of the Femoral Head. (26674675)
2016
2
Transtrochanteric rotational osteotomy for avascular necrosis of the femoral head after unstable slipped capital femoral epiphysis: 10-year clinical results. (27461924)
2016
3
Management of non-traumatic avascular necrosis of the femoral head-a comparative analysis of the outcome of multiple small diameter drilling and core decompression with fibular grafting. (27757848)
2016
4
Total hip arthroplasty after failed curved intertrochanteric varus osteotomy for avascular necrosis of the femoral head. (27019530)
2016
5
Geometric analysis of an expandable reamer for treatment of avascular necrosis of the femoral head. (26185054)
2015
6
Bilateral avascular necrosis of the femoral head due to the use of heroin: A case report. (26595896)
2015
7
Cotransplantation of bone marrow mononuclear cells and umbilical cord mesenchymal stem cells in avascular necrosis of the femoral head. (24507042)
2014
8
Stem cell treatment for avascular necrosis of the femoral head: current perspectives. (24744611)
2014
9
Avascular necrosis of the femoral head following trochanteric fractures in adults: a systematic review. (25467713)
2014
10
Trabecular metal screw implanted for avascular necrosis of the femoral head may complicate subsequent arthroplasty surgery. (23860809)
2013
11
Avascular necrosis of the femoral head in HIV positive patients-an assessment of risk factors and early response to surgical treatment. (24098826)
2013
12
The effects of treatment the avascular necrosis of the femoral head with extracorporeal focused shockwave therapy. (23208935)
2012
13
Genetic traits of avascular necrosis of the femoral head analyzed by array comparative genomic hybridization and real-time polymerase chain reaction. (21210629)
2011
14
Prediction of traumatic avascular necrosis of the femoral head by single photon emission computerized tomography and computerized tomography: an experimental study in dogs. (21801667)
2011
15
A systematic review of rigid, locked, intramedullary nail insertion sites and avascular necrosis of the femoral head in the skeletally immature. (21572274)
2011
16
Avascular necrosis of the femoral head in patients with Hodgkin's disease. (21157752)
2010
17
Avascular necrosis of the femoral head in sickle cell disease in Nigeria: a retrospective study. (17767206)
2007
18
Microsurgical fibular flap for treatment of avascular necrosis of the femoral head. (16427560)
2006
19
Pedicle bone grafting versus transtrochanteric rotational osteotomy for avascular necrosis of the femoral head. (12678351)
2003
20
Avascular necrosis of the femoral heads in a red panda (Ailurus fulgens fulgens): possible Legg-Calve-Perthes disease. (12462497)
2002
21
The influence of the biomechanical parameters of the hip on the outcome of treatment of hips subject to avascular necrosis of the femoral head. (11944058)
2002
22
Avascular necrosis of the femoral head in chronic myeloid leukemia patients treated with interferon-alpha: a synergistic correlation? (11013361)
2000
23
Prognosis of early stage avascular necrosis of the femoral head. (9973986)
1999
24
Avascular necrosis of the femoral head after intertrochanteric fractures. (9892118)
1999
25
No link between avascular necrosis of the femoral head and antiphospholipid antibodies. (9513610)
1997
26
Diagnostic patterns for bone marrow oedema syndrome and avascular necrosis of the femoral head in dynamic bone scintigraphy. (9481765)
1997
27
Vascularized pedicle bone-grafting for nontraumatic avascular necrosis of the femoral head. A 5- to 11-year follow-up. (9177798)
1997
28
Long-term follow-up of avascular necrosis of the femoral head in the dog. (8642794)
1996
29
Avascular necrosis of the femoral head after closed intramedullary shortening in an adolescent. (7883921)
1995
30
Avascular necrosis of the femoral head following pertrochanteric fracture. (7649660)
1995
31
Imaging study on the mode of development and changes in avascular necrosis of the femoral head in systemic lupus erythematosus: long-term observations. (8156306)
1994
32
Management of avascular necrosis of the femoral head. (8049758)
1994
33
Transtrochanteric anterior rotational osteotomy for avascular necrosis of the femoral head. Long-term results. (8331115)
1993
34
Bipolar prosthetic replacement for the treatment of avascular necrosis of the femoral head. (1555332)
1992
35
Iliac periosteal graft with vascular pedicle in the treatment of avascular necrosis of the femoral head. Experimental study and clinical application. (1291204)
1992
36
Magnetic resonance imaging and scintigraphy of avascular necrosis of the femoral head. Prediction of subsequent segmental collapse. (1555357)
1992
37
Detection of acute avascular necrosis of the femoral head in dogs: dynamic contrast-enhanced MR imaging vs spin-echo and STIR sequences. (1442396)
1992
38
Middle and long-term results of flexion osteotomy for avascular necrosis of the femoral head. (1399535)
1992
39
Silent avascular necrosis of the femoral head in haemophilia. (3192571)
1988
40
Avascular necrosis of the femoral head: high-field-strength MR imaging with histologic correlation. (3175001)
1988
41
Avascular necrosis of the femoral head in sickle-cell disease. A series from the Guinea Savannah of Nigeria. (3968138)
1985
42
MR imaging of iliopsoas bursitis and concurrent avascular necrosis of the femoral head. (4031179)
1985
43
Treatment of avascular necrosis of the femoral head. (6671916)
1983
44
Avascular necrosis of the femoral head: association with adjuvant chemotherapy for breast carcinoma. (7407772)
1980
45
The current status of avascular necrosis of the femoral head. (657642)
1978
46
Nonunion of the femoral neck and avascular necrosis of the femoral head: treatment with bone grafts. (331483)
1977
47
Avascular necrosis of the femoral head in patients on chronic hemodialysis. (4610967)
1972
48
Nontraumatic avascular necrosis of the femoral head. (4937460)
1971
49
AVASCULAR NECROSIS OF THE FEMORAL HEAD IN THE DOG. (14283893)
1965
50
Avascular necrosis of the femoral head associated with sickle cell trait (AS hemoglobin). (14490507)
1962

Variations for Avascular Necrosis of the Femoral Head

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UniProtKB/Swiss-Prot genetic disease variations for Avascular Necrosis of the Femoral Head:

69
id Symbol AA change Variation ID SNP ID
1COL2A1p.Gly717SerVAR_023929rs387906558
2COL2A1p.Gly1170SerVAR_023933rs121912891
3COL2A1p.Thr1383MetVAR_075730rs138498898

Clinvar genetic disease variations for Avascular Necrosis of the Femoral Head:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)SNVPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835

Expression for genes affiliated with Avascular Necrosis of the Femoral Head

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Search GEO for disease gene expression data for Avascular Necrosis of the Femoral Head.

Pathways for genes affiliated with Avascular Necrosis of the Femoral Head

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GO Terms for genes affiliated with Avascular Necrosis of the Femoral Head

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Cellular components related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.1APOB, HLA-DRB1
2chylomicronGO:004262710.1APOA1, APOB
3very-low-density lipoprotein particleGO:003436110.1APOA1, APOB
4endocytic vesicle lumenGO:007168210.0APOA1, APOB
5ER to Golgi transport vesicle membraneGO:00125079.9HLA-DRB1, SREBF2
6endoplasmic reticulum lumenGO:00057889.5APOA1, APOB, COL2A1
7extracellular regionGO:00055767.9APOA1, APOB, COL2A1, IGFBP3, LEP, SOD1
8extracellular exosomeGO:00700627.4ABCB1, APOA1, APOB, CAT, HLA-DRB1, IGFBP3
9extracellular spaceGO:00056157.3APOA1, APOB, CAT, COL2A1, IGFBP3, LEP

Biological processes related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytokine productionGO:000181910.2LEP, SOD1
2regulation of intestinal cholesterol absorptionGO:003030010.2APOA1, LEP
3response to vitamin EGO:003319710.1CAT, LEP
4response to reactive oxygen speciesGO:000030210.0CAT, SOD1
5regulation of protein phosphorylationGO:000193210.0APOA1, LEP
6lipoprotein biosynthetic processGO:004215810.0APOA1, APOB
7cholesterol effluxGO:003334410.0APOA1, APOB
8placenta developmentGO:00018909.9LEP, SOD1
9cholesterol transportGO:00303019.9APOA1, APOB
10lipoprotein metabolic processGO:00421579.8APOA1, APOB
11triglyceride catabolic processGO:00194339.7APOA1, APOB
12positive regulation of cholesterol storageGO:00108869.6APOB, SREBF2
13response to ethanolGO:00454719.2CAT, LEP, SOD1
14lipid metabolic processGO:00066298.8APOB, LEP, SREBF2
15response to drugGO:00424938.5ABCB1, APOA1, CAT, SOD1
16cholesterol metabolic processGO:00082037.8APOA1, APOB, CAT, LEP, SREBF2

Molecular functions related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:00171279.3APOA1, APOB

Sources for Avascular Necrosis of the Femoral Head

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet