ANFH
MCID: AVS004
MIFTS: 56

Avascular Necrosis of the Femoral Head (ANFH) malady

Categories: Genetic diseases, Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis of the Femoral Head

About this section

Aliases & Descriptions for Avascular Necrosis of the Femoral Head:

Name: Avascular Necrosis of the Femoral Head 52 35 12
Avascular Necrosis of Femoral Head, Primary 52 24
Femur Head Necrosis 39 68
Anfh 24 70
Avascular Necrosis of the Femoral Head, Primary 70
Familial Avascular Necrosis of Femoral Head 54
 
Familial Osteonecrosis of the Femoral Head 54
Avascular Necrosis of Femoral Head 70
Ischemic Necrosis of Femoral Head 70
Aseptic Necrosis of Femoral Head 70
Avascular Necrosis of Femur Head 68
Osteonecrosis of Femoral Head 70

Characteristics:

Orphanet epidemiological data:

54
familial avascular necrosis of femoral head:
Inheritance: Autosomal dominant; Prevalence: 1-9/100000 (United States); Age of onset: Adult

HPO:

64
avascular necrosis of the femoral head:
Inheritance: autosomal dominant inheritance

Classifications:

Orphanet: 54 
Rare bone diseases


External Ids:

OMIM52 608805
Orphanet54 ORPHA86820
ICD10 via Orphanet31 M87.8
MedGen37 C0410480
MeSH39 D005271

Summaries for Avascular Necrosis of the Femoral Head

About this section
UniProtKB/Swiss-Prot:70 Avascular necrosis of the femoral head, primary: A disease characterized by mechanical failure of the subchondral bone, and degeneration of the hip joint. It usually leads to destruction of the hip joint in the third to fifth decade of life. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability.

MalaCards based summary: Avascular Necrosis of the Femoral Head, also known as avascular necrosis of femoral head, primary, is related to familial avascular necrosis of the femoral head and sickle cell disease, and has symptoms including avascular necrosis of the capital femoral epiphysis An important gene associated with Avascular Necrosis of the Femoral Head is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways are Vitamin digestion and absorption and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, bone marrow and endothelial, and related mouse phenotypes are cardiovascular system and integument.

Description from OMIM:52 608805

Related Diseases for Avascular Necrosis of the Femoral Head

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Diseases in the Avascular Necrosis of the Femoral Head family:

Familial Avascular Necrosis of the Femoral Head

Diseases related to Avascular Necrosis of the Femoral Head via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1familial avascular necrosis of the femoral head12.6
2sickle cell disease10.5
3osteonecrosis10.5
4traumatic avascular necrosis10.4
5leukemia10.2
6endotheliitis10.2
7pleural tuberculosis10.2LEP, SOD1
8systemic lupus erythematosus10.2
9arthritis10.2
10lupus erythematosus10.2
11idiopathic avascular necrosis10.2
12nystagmus, congenital motor, autosomal recessive10.2HLA-DRB1, LEP
13metatropic dysplasia10.2COL2A1, TRPV4
14epiphyseal dysplasia, multiple, with myopia and deafness10.2COL2A1, TRPV4
15albinism, oculocutaneous, type v10.2APOA1, APOB
16osteoarthritis10.1
17bursitis10.1
18slipped capital femoral epiphysis10.1
19craniodiaphyseal dysplasia10.1APOA1, APOB
20transient retinal arterial occlusion10.1APOA1, APOB
21neurological manifestations of pompe disease10.1CAT, SOD1
22sp7-related osteogenesis imperfecta10.1COL2A1, TRPV4
23joint disorders10.1APOA1, APOB
24fetal alcohol spectrum disorder10.1COL2A1, TRPV4
25bird fancier's lung10.0APOA1, APOB
26rheumatoid arthritis10.0
27prostate cancer10.0
28lymphoma10.0
29lymphoblastic leukemia10.0
30prostatitis10.0
31periostitis10.0
32back pain10.0
33myositis fibrosa10.0CAT, SOD1
34lipomatosis10.0APOA1, APOB, LEP
35body dysmorphic disorder10.0APOA1, APOB, LEP
36skin squamous cell carcinoma10.0APOA1, APOB
37chondrocalcinosis with early-onset osteoarthritis10.0APOA1, APOB
38bell's palsy10.0IGFBP3, SOD1
39mitochondrial complex iii deficiency, nuclear type 410.0APOA1, APOB
40narcolepsy 69.9APOA1, APOB, SREBF2
41pityriasis rubra pilaris9.9IGFBP3, TRPV4
42spinocerebellar ataxia 209.9APOA1, APOB
43neuroblastoma9.9
44hiv-19.9
45trichorhinophalangeal syndrome, type i9.9
46legg-calve-perthes disease9.9
47metachondromatosis9.9
48acute leukemia9.9
49cerebral palsy9.9
50male infertility9.9

Graphical network of the top 20 diseases related to Avascular Necrosis of the Femoral Head:



Diseases related to avascular necrosis of the femoral head

Symptoms & Phenotypes for Avascular Necrosis of the Femoral Head

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Clinical features from OMIM:

608805

Human phenotypes related to Avascular Necrosis of the Femoral Head:

 64
id Description HPO Frequency HPO Source Accession
1 avascular necrosis of the capital femoral epiphysis64 HP:0005743

MGI Mouse Phenotypes related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.7ABCB1, APOA1, APOB, COL2A1, LEP, SOD1
2MP:00107718.6APOA1, IGFBP3, LEP, SOD1, SREBF2, TRPV4
3MP:00053918.0APOB, COL2A1, LEP, SOD1, SREBF2, TRPV4
4MP:00053707.7ABCB1, APOA1, APOB, COL2A1, IGFBP3, LEP
5MP:00053766.7ABCB1, APOA1, APOB, CAT, COL2A1, IGFBP3

Drugs & Therapeutics for Avascular Necrosis of the Femoral Head

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Drugs for Avascular Necrosis of the Femoral Head (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 99)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AlendronateapprovedPhase 4162121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
2
MethyclothiazideapprovedPhase 45135-07-94121
Synonyms:
(+-)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
135-07-9
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-,1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxid
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1
AC1L1HGJ
AC1Q6TPS
AR-1J4220
Aquaresen
Aquatensen
BRN 0765361
C07765
C9H11Cl2N3O4S2
CHEMBL1577
CI-625
CID4121
Ciba 7272-Su
D00656
DB00232
Duretic
EINECS 205-172-2
Enduron
Enduron (TN)
Enduronum
 
HSDB 3363
I06-1878
LS-40433
METHYLCLOTHIAZIDE
MLS002704228
Methychlothiazide
Methyclothiazid
Methyclothiazide (JAN/USP/INN)
Methyclothiazide [USAN:INN:BAN:JAN]
Methyclothiazidum
Methyclothiazidum [INN-Latin]
Methycyclothiazide
Methylchlorothiazide
Methylclothiazide
Methylcyclothiazide
Meticlotiazida
Meticlotiazida [INN-Spanish]
Meticlotiazide
Meticlotiazide [DCIT]
NCGC00167446-01
NSC 110431
NSC-110431
NSC110431
Naturon
Naturon (VAN)
SBB070984
SMR001550236
UNII-L3H46UAC61
WLN: T66 BSWN EM DHJ C1 D1G HG ISZW
e
methyclothiazide
3
DalteparinapprovedPhase 43179041-08-1
Synonyms:
Daltepariininatrium
Dalteparin Sodyum
Dalteparin sodium
Dalteparin sodná sůl
Dalteparin-nátrium
Dalteparina sódica
 
Dalteparinnatrium
Dalteparino natrio druska
Dalteparinum Natricum
Dalteparyna sodowa
Daltéparine sodique
Heparin Fragment KABI 2165
Tedelparin
4
Etidronic acidapprovedPhase 4827414-83-7, 2809-21-43305
Synonyms:
(1-Hydroxyethylene)diphosphonic acid
(1-Hydroxyethylidene)bis(phosphonic acid)
(1-Hydroxyethylidene)bisphosphonic acid
(1-Hydroxyethylidene)diphoshonic acid
(1-Hydroxyethylidene)diphosphonic acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
(1-hydroxy-ethylidene)diphosphonic acid
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
(Hydroxyethylidene)diphosphonic acid
0-02-00-00171 (Beilstein Handbook Reference)
1,1,1-Ethanetriol diphosphonate
1-HYDROXY-1,1-DIPHOSPHONOETHANE
1-Hydroxy-1,1-diphosphonoethane
1-Hydroxyethane-1,1,-diphosphonic acid
1-Hydroxyethane-1,1-bisphosphonic acid
1-Hydroxyethane-1,1-diphosphonate
1-Hydroxyethane-1,1-diphosphonic acid
1-Hydroxyethanediphosphonic acid
1-Hydroxyethylidene 1,1-diphosphonic acid
1-Hydroxyethylidene-1,1-biphosphonate
1-Hydroxyethylidene-1,1-bisphosphonate
1-Hydroxyethylidene-1,1-diphosphonic acid
1-Hydroxyethylidenediphosphonic acid
1-hydroxyethane 1,1-diphosphonic acid
1000SL
100511-44-2
103736-66-9
106908-76-3
129130-42-3
138360-84-6
14860-53-8 (tetra-potassium salt)
192526-55-9
2809-21-4
303177-33-5
51888-66-5
54342_ALDRICH
54342_FLUKA
66216-98-6
853028-38-3
85985-26-8
86159-18-4
AC1L1FMT
Acetodiphosphonic acid
Acide etidronique
Acide etidronique [INN-French]
Acido etidronico
Acido etidronico [INN-Spanish]
Acidum etidronicum
Acidum etidronicum [INN-Latin]
BPBio1_000997
BRN 1789291
BSPBio_000905
Bio-0708
C07736
CHEBI:170675
CHEBI:4907
CHEMBL871
CID3305
 
Cintichem Technetium 99m Hedspa
D02373
DB01077
Dequest 2010
Dequest 2015
Dequest Z 010
Didronel
Didronel IV
Diphosphonate (base)
EHDP
EINECS 220-552-8
Ethane-1-hydroxy-1,1-bisphosphonate
Ethane-1-hydroxy-1,1-bisphosphonic acid
Ethane-1-hydroxy-1,1-diphosphonate
Ethane-1-hydroxy-1,1-diphosphonic acid
Etidronate
Etidronate Disodium
Etidronic acid
Etidronic acid (USAN/INN)
Etidronic acid [USAN:INN:BAN]
Etidronic acid monohydrate
Etidronsaeure
Etidronsäure
Ferrofos 510
H0587
H6773_ALDRICH
H6773_SIGMA
HEDP
HSDB 5898
Hydroxyethane-1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
I14-1271
Jsp005415
LS-106637
MLS002207267
MLS002695948
MPI Stannous Diphosphonate
MolPort-001-786-542
NCGC00159352-02
NSC 227995
NSC227995
Osteoscan
Oxyethylidenediphosphonic acid
Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
Prestwick0_000863
Prestwick1_000863
Prestwick2_000863
Prestwick3_000863
RP 61
SMR000038750
SPBio_002826
STK721995
Turpinal SL
UNII-M2F465ROXU
acide étidronique
acidum etidronicum
ethane-1-hydroxy-1,1-bisphosphonic acid
etidronate
ácido etidrónico
5
Heparinapproved, investigationalPhase 48489005-49-6772, 46507594
Synonyms:
101921-26-0
102-94-3
102785-31-9
104521-37-1
11078-24-3
11129-39-8
12656-11-0
2-o-sulfohexopyranuronosyl-(1->4)-2-deoxy-3-o-sulfo-2-(sulfoamino)hexopyranosyl-(1->4)-2-o-sulfohexopyranuronosyl-(1->4)-2-acetamido-2-deoxy-6-o-sulfohexopyranose
37324-73-5
6-[6-[6-[5-acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-2-carboxy-4-hydroxy-5-sulfooxyoxan-3-yl]oxy-2-(hydroxymethyl)-5-(sulfoamino)-4-sulfooxyoxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid
9041-08-1
9045-22-1
9075-96-1
913079-23-9
91449-79-5
AC1L19ZN
AC1L1ROY
ALFA 87-120
ALFA 87-163
ALFA 87-198
ALFA 87-81
ALFA 88-247
AR-1E4539
Allocinnamic acid
Ardeparin
Ardeparin sodium
Arteven
Bemiparin
Bemiparin sodium
CID772
CID8784
CY 216
Calciparine
Certoparin
Clexane
Clivarin
Clivarine
Cy 222
D006495
D017984
DB00407
DB01225
Dalteparin
Dalteparin sodium
Depo-Heparin
EINECS 232-681-7
EMT 966
EMT 967
EMT-966
EMT-967
EMT966
EMT967
Enoxaparin
Enoxaparin sodium
Enoxaparine
Eparina
Eparina [DCIT]
FR 860
Fluxum
Fragmin A
Fragmin B
Fragmin IV
Fraxiparin
H 2149
HSDB 3094
Hed-heparin
Hep Flush Kit in plastic container
Hep-Lock
Hep-Lock U/P
Hep-lock
Heparin
Heparin CY 216
Heparin Lock Flush
Heparin Lock Flush in plastic container
Heparin Lock Flush preservative free
Heparin Lock Flush preservative free in plastic container
Heparin Sodium
Heparin natrium
Heparin sodium
Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 1,000 units in dextrose 5% in plastic container
Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 10,000 units in dextrose 5%
Heparin sodium 10,000 units in dextrose 5% in plastic container
Heparin sodium 10,000 units in sodium chloride 0.45%
Heparin sodium 10,000 units in sodium chloride 0.9%
Heparin sodium 12,500 units in dextrose 5%
Heparin sodium 12,500 units in dextrose 5% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container
Heparin sodium 12,500 units in sodium chloride 0.9%
Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 2,000 units in dextrose 5% in plastic container
Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 20,000 units and dextrose 5% in plastic container
Heparin sodium 20,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units and dextrose 5% in plastic container
 
Heparin sodium 25,000 units in dextrose 5%
Heparin sodium 25,000 units in dextrose 5% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container
Heparin sodium 25,000 units in sodium chloride 0.9%
Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container
Heparin sodium 5,000 units in dextrose 5% in plastic container
Heparin sodium 5,000 units in sodium chloride 0.45%
Heparin sodium 5,000 units in sodium chloride 0.9%
Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container
Heparin sodium in plastic container
Heparin sodium preservative Free
Heparin sulfate
Heparin sulphate
Heparin, Low Molecular Weight
Heparin, Low-Molecular-Weight
Heparin, sodium salt
Heparina
Heparina [INN-Spanish]
Heparinate
Heparine
Heparine [INN-French]
Heparinic acid
Heparinsodiumsalt
Heparinum
Heparinum [INN-Latin]
Heparinum natricum
Hepathrom
Hepflush-10
Inno-Hep
Innohep
Isocinnamic acid
KB 101
Kabi 2165
LHN 1
LMWH
Lioton 1000
Lipo-hepin
Liquaemin
Liquaemin Lock Flush
Liquaemin Sodium
Liquaemin sodium preservative free
Liquemin
Logiparin
Lovenox
Lovenox HP
Low Molecular Weight Heparin
Low molecular weight heparin
Low molecular weight heparin sodium
Low-Molecular-Weight Heparin
Minolteparin sodium
MolPort-003-760-257
Multiparin
NSC174025
Nadroparin
Nadroparine
Novoheparin
OP 386
OP 622
Octaparin
PK 10,169
PK-10,169
PK-10169
PK10,169
PK10169
Pabyrin
Panheprin
Parnaparin
Parnaparin sodium
Parvoparin
Pularin
Reviparin
Reviparin sodium
Ro 11
Sandoparin
Sodium acid heparin
Sodium heparin
Sodium heparinate
Subeparin
Sublingula
Thromboliquine
Tinzaparin
Tinzaparin sodium
Triofiban
UNII-12M44VTJ7B
UNII-3S182ET3UA
UNII-E47C0NF7LV
UNII-T2410KM04A
UNII-ZZ45AB24CA
Unfractionated heparin
Vetren
Vitrum AB
WY 90493RD
alpha-Heparin
cis-.beta.-Carboxystyrene
cis-Cinnamic acid
enoxaparin
heparin
6
RivaroxabanapprovedPhase 4259366789-02-8
Synonyms:
 
Xarelto
bay 59-7939
7AnestheticsPhase 4, Phase 3, Phase 2, Early Phase 19596
8Calcium, DietaryPhase 4, Phase 3, Phase 25713
9Natriuretic AgentsPhase 41697
10Bone Density Conservation AgentsPhase 4, Phase 3, Phase 23376
11Sodium Chloride Symporter InhibitorsPhase 4452
12diureticsPhase 41418
13Serine Proteinase InhibitorsPhase 4878
14glucocorticoidsPhase 45103
15HormonesPhase 4, Phase 214415
16Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 213168
17Hormone AntagonistsPhase 4, Phase 213180
18AnticoagulantsPhase 42623
19calcium heparinPhase 4848
20AntithrombinsPhase 4697
21Antithrombin IIIPhase 4690
22Factor Xa InhibitorsPhase 4411
23Heparin, Low-Molecular-WeightPhase 4334
24
protease inhibitorsPhase 45471
Synonyms:
 
protease inhibitors
25HIV Protease InhibitorsPhase 45470
26Hydroxymethylglutaryl-CoA Reductase InhibitorsPhase 41998
27Lipid Regulating AgentsPhase 42766
28Hypolipidemic AgentsPhase 42785
29Atorvastatin CalciumPhase 4760134523-03-8
30Anticholesteremic AgentsPhase 42025
31AntimetabolitesPhase 412054
32serineNutraceuticalPhase 4954
33
Zoledronic acidapprovedPhase 3, Phase 2294118072-93-868740
Synonyms:
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
(1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate
(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
118072-93-8
2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
AC-1092
AC1L2ACJ
AC1Q6RN3
AKOS005145739
Aclasta
Anhydrous Zoledronic Acid
BIDD:GT0292
BIDD:PXR0134
Bio-0112
Bisphosphonate 3
C088658
CGP 42'446
CGP 42446
CGP 42446A
CGP-42'446
CGP-42446
CHEBI:46557
CHEMBL924
CID68740
D08689
DB00399
 
FT-0082657
HMS2089O09
I06-0710
KS-1132
LS-181815
MolPort-002-885-874
MolPort-003-850-890
NCGC00159521-02
NCGC00159521-03
NSC721517
Novartis brand of zoledronic acid
Reclast
Reclast (TN)
S00092
S1314_Selleck
UNII-70HZ18PH24
ZOL
Zol
Zoledronate
Zoledronic Acid Anhydrous
Zoledronic Acid, Anhydrous
Zoledronic acid
Zoledronic acid (INN)
Zoledronic acid [USAN:INN]
Zometa
Zometa (Novartis)
Zometa (TN)
Zometa Concentrate
Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
34
DonepezilapprovedPhase 3286120014-06-43152
Synonyms:
( inverted exclamation markA)-E 2020
1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine
120014-06-4
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one
AB1004836
AC-6969
AC1L1FAE
AKOS000277311
Aricept
Aricept ODT
C24H29NO3
CHEBI:53289
CHEMBL502
CID3152
D07869
DB00843
Domepezil
Donaz
Donaz (TN)
 
Donepezil
Donepezil (INN)
Donepezil [INN:BAN]
Donepezil hydrochloride
Donepezilo
Donepezilum
Eranz
I06-0343
KBio2_002144
KBio2_004712
KBio2_007280
KBioSS_002144
LS-81819
MolPort-000-881-588
MolPort-003-847-014
NCGC00167537-01
Oprea1_188452
Spectrum5_001662
Spectrum_001664
TL8000531
UNII-8SSC91326P
35Cholinergic AgentsPhase 33992
36DiphosphonatesPhase 3, Phase 2450
37Neurotransmitter AgentsPhase 318340
38Ibandronic acidPhase 380
39Fibrin Tissue AdhesivePhase 3148
40vitamin dPhase 31724
41HemostaticsPhase 31443
42CoagulantsPhase 31500
43Cholinesterase InhibitorsPhase 3592
44Nootropic AgentsPhase 3716
45
Ketoconazoleapproved, investigationalPhase 217565277-42-147576, 3823
Synonyms:
(+)-Ketoconazole
(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1- ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
(+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
65277-42-1
79156-75-5
AC-15957
AC1L9UG3
BIDD:GT0696
BIM-0050645.0001
BPBio1_000635
BRD-K29113274-001-03-6
BRN 4303081
BSPBio_000577
C26H28Cl2N4O4
CHEBI:48336
CHEMBL75
CID456201
CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE
CPD000058460
EINECS 265-667-4
EU-0100666
Extina
Fungarest
Fungoral
HMS1569M19
HMS2051A19
HMS2089N05
HSDB 7447
K 1003
K0045
K1003_SIGMA
KCZ
KS-1205
KTZ
KW-1414
KZ
Ketoconazol
Ketoconazole
Ketoconazole [USAN:INN:BAN:JAN]
Ketoconazolum
Ketoderm
Ketoisdin
Ketozole
 
LS-110149
Lopac0_000666
MLS000069784
MLS000758224
MLS001146934
MLS002207053
MLS002222255
MolPort-003-848-307
NCGC00025000-01
NCGC00025000-02
NCGC00025000-03
NCGC00025000-04
NCGC00025000-05
NCGC00025000-06
NCGC00025000-07
NCGC00025000-08
NCGC00025000-09
NSC 317629
NSC317629
Nizoral
Nizoral a-D
Nizoral, Extina, Xolegel, Kuric, Ketoconazole
Orifungal M
Panfungol
Piperazine
Prestwick0_000389
Prestwick1_000389
Prestwick2_000389
Prestwick3_000389
Prestwick_744
R 41,400
R 41400
R-41400
R41,400
R41400
S1353_Selleck
SAM001246983
SMR000058460
SPBio_002498
Tocris-1103
UC280_SIGMA
UPCMLD-DP138
UPCMLD-DP138:001
Xolegel
cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H- imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-ketoconazol
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine
ketoconazole
46
Miconazoleapproved, investigational, vet_approvedPhase 2370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
47Cytochrome P-450 CYP3A InhibitorsPhase 21715
48Antifungal AgentsPhase 23696
49Steroid Synthesis InhibitorsPhase 21763
50Anti-Infective AgentsPhase 222062

Interventional clinical trials:

(show top 50)    (show all 93)
idNameStatusNCT IDPhase
1Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic OsteonecrosisUnknown statusNCT00265252Phase 4
2A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip ReplacementUnknown statusNCT00208442Phase 4
3Benefit of Orthopedic Navigation in the ARThroplasty of the HipCompletedNCT01496300Phase 4
4Prophylaxis of Deep Vein Thrombosis Following Total Hip ArthroplastyCompletedNCT02379663Phase 4
5Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years OldCompletedNCT02338596Phase 4
6Vertebral Fracture and Osteonecrosis Associated With High-dose GlucocorticoidCompletedNCT00679978Phase 4
7Assessment of the Effects of Atorvastatin Therapy on Myocardial Deformation Characteristics, in Patients With STEMIRecruitingNCT02590653Phase 4
8Efficacy of the CLP® Hip - RetrospectiveTerminatedNCT00764842Phase 4
9Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip ReplacementTerminatedNCT00872547Phase 4
10Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH)Unknown statusNCT01613612Phase 2, Phase 3
11Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected SubjectsUnknown statusNCT00172315Phase 3
12Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral HeadCompletedNCT00939900Phase 3
13Efficacy and Safety of Fibrin Sealant Vapor Heated Solvent/Detergent Treated (FS VH S/D) for Hemostasis in Subjects Undergoing Total Hip ReplacementCompletedNCT00161902Phase 3
14Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled TrialCompletedNCT00532220Phase 3
15Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral HeadRecruitingNCT01892514Phase 3
16Phase 3 Study on Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral HeadRecruitingNCT01529008Phase 3
17Trinity™ BIOLOX Delta™ CoC THR Multi-center StudyActive, not recruitingNCT01921309Phase 3
18A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in ChinaActive, not recruitingNCT02399007Phase 3
19Donepezil Attenuate Postoperative Cognitive DysfunctionNot yet recruitingNCT02927522Phase 3
20A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
21Evaluation of Mesenchymal Stem Cells to Treat Avascular Necrosis of the HipUnknown statusNCT02065167Phase 2
22MBCP Safety and Performance in the Osteonecrosis of Femur HeadUnknown statusNCT00289575Phase 2
23Osteonecrosis of the Hip and Bisphosphonate TreatmentUnknown statusNCT00781261Phase 2
24Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee SurgeryCompletedNCT00393848Phase 2
25Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral HeadCompletedNCT01643655Phase 1, Phase 2
26Autologous Osteoblastic Cells Implantation to Early Stage Osteonecrosis of the Femoral HeadCompletedNCT02890537Phase 2
27Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral HeadCompletedNCT00505219Phase 2
28PHASE II CLINICAL TRIAL Prospective, Open, Nonrandomized Treatment of Osteonecrosis of the Femoral Head by the Administration of Autologous Mesenchymal Stem CellsCompletedNCT01700920Phase 2
29Mesenchymal Stem Cells in Osteonecrosis of the Femoral HeadRecruitingNCT01605383Phase 1, Phase 2
30Autologous Bone Marrow Stem Cell Transplantation for Hip Osteonecrosis in Sickle Cell DiseaseEnrolling by invitationNCT02448121Phase 1, Phase 2
31The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem CellsNot yet recruitingNCT03180463Phase 1, Phase 2
32Treatment of Osteonecrosis of the Femoral Head by Bone Marrow TransplantationCompletedNCT00821470Phase 1
33Evaluate the Effect of Bone Marrow Derived Cd133+ Cells in Patient With Osteonecrosis of Femoral HeadCompletedNCT01198080Phase 1
34Molecular Genetic Study of Avascular Necrosis of the Femoral HeadUnknown statusNCT00260897
35Mesenchymal Stem Cell for Osteonecrosis of the Femoral HeadUnknown statusNCT00813267Early Phase 1
36Comparison of Hip Resurfacing to Large Femoral Head Total Hip ArthroplastyUnknown statusNCT00175487
37Ketamine Prevent POCDUnknown statusNCT02220400
38Acetylcholine and Postoperative Cognitive Change in Aged PatientsUnknown statusNCT02063542
39A Comparison of Two Different Surgical Techniques in Hip Resurfacing ArthroplastyUnknown statusNCT00913679
40Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head NecrosisCompletedNCT00244400
41Transcription Factor Runx2 in Necrotic Femoral Head TissueCompletedNCT02735538
42Clinical and Radiological Results of Total Hip Arthroplasty Using a Ceramic Friction PairCompletedNCT02062437
43The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral HeadCompletedNCT02007915
44Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular CupCompletedNCT02062450
45Rotational Thromboelastography Study in Tranexamic Acid and Colloid InfusionCompletedNCT02146456
46The Long Term Outcome of Varus Derotational Osteotomy for Legg-Calvé-Perthes' DiseaseCompletedNCT02676271
47Controlled Study of Stage 3 Osteonecrosis Treatment by Bone MarrowCompletedNCT01544712
48Project JAY THA Registration StudyCompletedNCT02347384
49A Clinical Investigation of the C2a-Taper™ Acetabular SystemCompletedNCT00578851
50Selective Ultrasound Screening for DDH 1991-2006CompletedNCT01866527

Search NIH Clinical Center for Avascular Necrosis of the Femoral Head

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Avascular Necrosis of the Femoral Head:
RNL-Astrostem
Embryonic/Adult Cultured Cells Related to Avascular Necrosis of the Femoral Head:
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080


Cochrane evidence based reviews: femur head necrosis

Genetic Tests for Avascular Necrosis of the Femoral Head

About this section

Genetic tests related to Avascular Necrosis of the Femoral Head:

id Genetic test Affiliating Genes
1 Avascular Necrosis of Femoral Head, Primary24 COL2A1

Anatomical Context for Avascular Necrosis of the Femoral Head

About this section

MalaCards organs/tissues related to Avascular Necrosis of the Femoral Head:

36
Bone, Bone marrow, Endothelial, Heart, Myeloid, Prostate, Pituitary

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Avascular Necrosis of the Femoral Head:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Publications for Avascular Necrosis of the Femoral Head

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Articles related to Avascular Necrosis of the Femoral Head:

(show top 50)    (show all 365)
idTitleAuthorsYear
1
Total hip arthroplasty after failed curved intertrochanteric varus osteotomy for avascular necrosis of the femoral head. (27019530)
2016
2
Risk factors of avascular necrosis of the femoral head and fixation failure in patients with valgus angulated femoral neck fractures over the age of 50 years. (27793326)
2016
3
Multiple Small Diameter Drillings Increase Femoral Neck Stability Compared with Single Large Diameter Femoral Head Core Decompression Technique for Avascular Necrosis of the Femoral Head. (27466872)
2016
4
Effects of Focused Extracorporeal Shock Waves on Bone Marrow Mesenchymal Stem Cells in Patients with Avascular Necrosis of the Femoral Head. (26674675)
2016
5
Roles of osteocyte apoptosis in steroid-induced avascular necrosis of the femoral head. (27050956)
2016
6
F-18 fluoride positron emission tomography/computed tomography in the diagnosis of avascular necrosis of the femoral head: Comparison with magnetic resonance imaging. (26917886)
2016
7
Tao-Hong-Si-Wu Decoction ameliorates steroid-induced avascular necrosis of the femoral head by regulating the HIF-1I+ pathway and cell apoptosis. (27558153)
2016
8
Avascular necrosis of the femoral head at 2 years after pertrochanteric fracture surgery: Case report. (26900462)
2016
9
Bilateral avascular necrosis of the femoral head following treatment of Ewing's sarcoma. (26586407)
2016
10
Effects of hypoxia on osteogenic differentiation of mesenchymal stromal cells used as a cell therapy for avascular necrosis of the femoral head. (27421741)
2016
11
Role of Ayurveda in the conservative management of avascular necrosis of the femoral head: A case study. (27143802)
2016
12
Evaluation of the stability of reference genes in bone mesenchymal stem cells from patients with avascular necrosis of the femoral head. (27323096)
2016
13
Inter-observer and intra-observer reliability in the radiographic diagnosis of avascular necrosis of the femoral head following reconstructive hip surgery in children with cerebral palsy. (26972813)
2016
14
Transtrochanteric rotational osteotomy for avascular necrosis of the femoral head after unstable slipped capital femoral epiphysis: 10-year clinical results. (27461924)
2016
15
In vitro and in vivo evaluation of calcium phosphate composite scaffolds containing BMP-VEGF loaded PLGA microspheres for the treatment of avascular necrosis of the femoral head. (26706534)
2016
16
Impaired osteogenic differentiation associated with connexin43/microRNA-206 in steroid-induced avascular necrosis of the femoral head. (27450649)
2016
17
Core Decompression Augmented With Autologous Bone Marrow Aspiration Concentrate for Early Avascular Necrosis of the Femoral Head. (27656386)
2016
18
Incidence of Avascular Necrosis of the Femoral Head After Intramedullary Nailing of Femoral Shaft Fractures: A Multicenter Retrospective Analysis of 542 Cases. (26844518)
2016
19
Management of non-traumatic avascular necrosis of the femoral head-a comparative analysis of the outcome of multiple small diameter drilling and core decompression with fibular grafting. (27757848)
2016
20
Early treatment with the von Rosen splint for neonatal instability of the hip is safe regarding avascular necrosis of the femoral head. (26730503)
2016
21
Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: a randomized clinical trial. (26946617)
2016
22
Effectiveness of Lower Energy Density Extracorporeal Shock Wave Therapy in the Early Stage of Avascular Necrosis of the Femoral Head. (27847717)
2016
23
The physiopathology of avascular necrosis of the femoral head: an update. (28040082)
2016
24
Avascular Necrosis of the Femoral Head After Palliative Radiotherapy in Metastatic Prostate Cancer: Absence of a Dose Threshold? (27081582)
2016
25
Evaluation of the muscle morphology of the obturator externus and piriformis as the predictors of avascular necrosis of the femoral head in acetabular fractures. (27116689)
2016
26
Aspects of postoperative magnetic resonance imaging of patients with avascular necrosis of the femoral head, treated by advanced core decompression. (26093539)
2015
27
Incremental value of 99mTc-MDP hybrid SPECT/CT over planar scintigraphy and SPECT in avascular necrosis of the femoral head. (26308940)
2015
28
A steroid-induced bilateral avascular necrosis of the femoral head in an underage patient affected by multiple sclerosis. (26811707)
2015
29
Repair effect of coexpression of the hVEGF and hBMP genes via an adeno-associated virus vector in a rabbit model of early steroid-induced avascular necrosis of the femoral head. (25843672)
2015
30
Avascular Necrosis of the Femoral Head: Are Any Genes Involved? (26213697)
2015
31
Hip resurfacing arthroplasty in treatment of avascular necrosis of the femoral head. (25618763)
2015
32
Avascular Necrosis of the Femoral Head Masquerading as Iliopsoas Bursitis: Imaging With Ultrasound and Magnetic Resonance. (26418490)
2015
33
Avascular necrosis of the femoral head. (25929162)
2015
34
Protective effects of total saponins of panax notoginseng on steroid-induced avascular necrosis of the femoral head in vivo and in vitro. (25694788)
2015
35
Bilateral avascular necrosis of the femoral head due to the use of heroin: A case report. (26595896)
2015
36
Vascular endothelial growth factor/bone morphogenetic protein-2 bone marrow combined modification of the mesenchymal stem cells to repair the avascular necrosis of the femoral head. (26629044)
2015
37
Nitric oxide content and apoptosis rate in steroid-induced avascular necrosis of the femoral head. (26622359)
2015
38
Geometric analysis of an expandable reamer for treatment of avascular necrosis of the femoral head. (26185054)
2015
39
Enoxaparin prevents steroid-related avascular necrosis of the femoral head. (25110730)
2014
40
Effectiveness of synovial fluid mesenchymal stem cells embedded in alginate beads for treatment of steroid-induced avascular necrosis of the femoral head. (24789300)
2014
41
Intra-articular loose body caused by avascular necrosis of the femoral head in children. (24045502)
2014
42
Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review. (24886648)
2014
43
A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg-CalvAc-Perthes disease or avascular necrosis of the femoral head. (24949742)
2014
44
ABCB1 gene polymorphisms and glucocorticoid-induced avascular necrosis of the femoral head susceptibility: a meta-analysis. (25544111)
2014
45
Avascular necrosis of the femoral head. (24979495)
2014
46
Evidence for using alendronate to treat adult avascular necrosis of the femoral head: a systematic review. (25424061)
2014
47
Stem cell treatment for avascular necrosis of the femoral head: current perspectives. (24744611)
2014
48
Cotransplantation of bone marrow mononuclear cells and umbilical cord mesenchymal stem cells in avascular necrosis of the femoral head. (24507042)
2014
49
Avascular necrosis of the femoral head following trochanteric fractures in adults: a systematic review. (25467713)
2014
50
Pro-osteogenic effects of fibrin glue in treatment of avascular necrosis of the femoral head in vivo by hepatocyte growth factor-transgenic mesenchymal stem cells. (24885252)
2014

Variations for Avascular Necrosis of the Femoral Head

About this section

UniProtKB/Swiss-Prot genetic disease variations for Avascular Necrosis of the Femoral Head:

70
id Symbol AA change Variation ID SNP ID
1COL2A1p.Gly717SerVAR_023929rs387906558
2COL2A1p.Gly1170SerVAR_023933rs121912891
3COL2A1p.Thr1383MetVAR_075730rs138498898

Clinvar genetic disease variations for Avascular Necrosis of the Femoral Head:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL2A1NM_ 001844.4(COL2A1): c.3508G> A (p.Gly1170Ser)SNVPathogenicrs121912891GRCh37Chr 12, 48369835: 48369835
2COL2A1NM_ 001844.4(COL2A1): c.2149G> A (p.Gly717Ser)SNVPathogenicrs387906558GRCh37Chr 12, 48376675: 48376675
3COL2A1NM_ 001844.4(COL2A1): c.4148C> T (p.Thr1383Met)SNVPathogenicrs138498898GRCh37Chr 12, 48368041: 48368041

Expression for genes affiliated with Avascular Necrosis of the Femoral Head

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Search GEO for disease gene expression data for Avascular Necrosis of the Femoral Head.

Pathways for genes affiliated with Avascular Necrosis of the Femoral Head

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GO Terms for genes affiliated with Avascular Necrosis of the Femoral Head

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Cellular components related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.4APOB, HLA-DRB1
2chylomicronGO:004262710.3APOA1, APOB
3endocytic vesicle lumenGO:007168210.3APOA1, APOB
4intermediate-density lipoprotein particleGO:00343639.9APOA1, APOB
5low-density lipoprotein particleGO:00343629.8APOA1, APOB
6cell surfaceGO:00099869.8ABCB1, APOA1, HLA-DRB1, TRPV4
7very-low-density lipoprotein particleGO:00343619.5APOA1, APOB
8endoplasmic reticulum lumenGO:00057889.5APOA1, APOB, COL2A1, IGFBP3
9cytoplasmic vesicleGO:00314109.5APOA1, SOD1, SREBF2, TRPV4
10extracellular regionGO:00055767.8APOA1, APOB, CAT, COL2A1, IGFBP3, LEP
11extracellular exosomeGO:00700627.8ABCB1, APOA1, APOB, CAT, HLA-DRB1, IGFBP3
12extracellular spaceGO:00056157.5APOA1, APOB, CAT, COL2A1, IGFBP3, LEP

Biological processes related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1cartilage development involved in endochondral bone morphogenesisGO:006035110.6COL2A1, TRPV4
2regulation of response to osmotic stressGO:004748410.5ABCB1, TRPV4
3placenta developmentGO:000189010.4LEP, SOD1
4positive regulation of cytokine productionGO:000181910.4LEP, SOD1
5regulation of intestinal cholesterol absorptionGO:003030010.4APOA1, LEP
6cholesterol effluxGO:003334410.2APOA1, APOB
7cholesterol transportGO:003030110.2APOA1, APOB
8chylomicron assemblyGO:003437810.2APOA1, APOB
9chylomicron remodelingGO:003437110.2APOA1, APOB
10lipoprotein biosynthetic processGO:004215810.2APOA1, APOB
11positive regulation of cholesterol storageGO:001088610.0APOB, SREBF2
12regulation of cholesterol biosynthetic processGO:004554010.0APOB, SREBF2
13protein tetramerizationGO:005126210.0CAT, HLA-DRB1
14response to vitamin EGO:00331979.9CAT, LEP
15response to reactive oxygen speciesGO:00003029.8CAT, SOD1
16cellular protein metabolic processGO:00442679.7APOA1, APOB, IGFBP3
17response to insulinGO:00328689.6CAT, LEP, TRPV4
18triglyceride catabolic processGO:00194339.5APOA1, APOB
19response to ethanolGO:00454719.5CAT, LEP, SOD1
20response to estradiolGO:00323559.4APOB, CAT, LEP
21steroid metabolic processGO:00082029.3APOA1, APOB, SREBF2
22lipid metabolic processGO:00066299.2APOA1, APOB, LEP, SREBF2
23response to drugGO:00424939.1ABCB1, APOA1, CAT, SOD1
24cholesterol metabolic processGO:00082038.4APOA1, APOB, CAT, LEP, SREBF2

Molecular functions related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:00171279.9APOA1, APOB
2antioxidant activityGO:00162099.7CAT, SOD1
3lipid transporter activityGO:00053199.5APOA1, APOB

Sources for Avascular Necrosis of the Femoral Head

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
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57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet