MCID: AVS004
MIFTS: 49

Avascular Necrosis of the Femoral Head malady

Genetic diseases, Bone diseases, Rare diseases categories

Aliases & Classifications for Avascular Necrosis of the Femoral Head

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Aliases & Descriptions for Avascular Necrosis of the Femoral Head:

Name: Avascular Necrosis of the Femoral Head 49 32 11
Avascular Necrosis of the Femoral Head, Primary 67
Avascular Necrosis of Femoral Head 67
Ischemic Necrosis of Femoral Head 67
 
Avascular Necrosis of Femur Head 65
Aseptic Necrosis of Femoral Head 67
Osteonecrosis of Femoral Head 67
Anfh 67


Classifications:



External Ids:

OMIM49 608805
MedGen34 C0410480
MeSH36 D005271

Summaries for Avascular Necrosis of the Femoral Head

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UniProtKB/Swiss-Prot:67 Avascular necrosis of the femoral head, primary: A disease characterized by mechanical failure of the subchondral bone, and degeneration of the hip joint. It usually leads to destruction of the hip joint in the third to fifth decade of life. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability.

MalaCards based summary: Avascular Necrosis of the Femoral Head, also known as avascular necrosis of the femoral head, primary, is related to sickle cell disease and familial avascular necrosis of the femoral head, and has symptoms including autosomal dominant inheritanceand avascular necrosis of the capital femoral epiphysis. An important gene associated with Avascular Necrosis of the Femoral Head is COL2A1 (Collagen, Type II, Alpha 1), and among its related pathways are Oxidative Stress and Doxorubicin Pathway, Pharmacokinetics. Affiliated tissues include bone, endothelial and bone marrow, and related mouse phenotypes are vision/eye and cardiovascular system.

Description from OMIM:49 608805

Related Diseases for Avascular Necrosis of the Femoral Head

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Graphical network of the top 20 diseases related to Avascular Necrosis of the Femoral Head:



Diseases related to avascular necrosis of the femoral head

Symptoms for Avascular Necrosis of the Femoral Head

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Clinical features from OMIM:

608805

HPO human phenotypes related to Avascular Necrosis of the Femoral Head:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 avascular necrosis of the capital femoral epiphysis HP:0005743

Drugs & Therapeutics for Avascular Necrosis of the Femoral Head

About this section

Drugs for Avascular Necrosis of the Femoral Head (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethyclothiazideapprovedPhase 45135-07-94121
Synonyms:
(+-)-6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
135-07-9
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-,1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxid
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-dioxide
6-Chloro-3-(chloromethyl)-2-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-3-chloromethyl-2-methyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
6-chloro-3-(chloromethyl)-2-methyl-1,1-dioxo-3,4-dihydro-1
AC1L1HGJ
AC1Q6TPS
AR-1J4220
Aquaresen
Aquatensen
BRN 0765361
C07765
C9H11Cl2N3O4S2
CHEMBL1577
CI-625
CID4121
Ciba 7272-Su
D00656
DB00232
Duretic
EINECS 205-172-2
Enduron
Enduron (TN)
Enduronum
HSDB 3363
 
I06-1878
LS-40433
METHYLCLOTHIAZIDE
MLS002704228
Methychlothiazide
Methyclothiazid
Methyclothiazide
Methyclothiazide (JAN/USP/INN)
Methyclothiazide [USAN:INN:BAN:JAN]
Methyclothiazidum
Methyclothiazidum [INN-Latin]
Methycyclothiazide
Methylchlorothiazide
Methylclothiazide
Methylcyclothiazide
Meticlotiazida
Meticlotiazida [INN-Spanish]
Meticlotiazide
Meticlotiazide [DCIT]
NCGC00167446-01
NSC 110431
NSC-110431
NSC110431
Naturon
Naturon (VAN)
SBB070984
SMR001550236
UNII-L3H46UAC61
WLN: T66 BSWN EM DHJ C1 D1G HG ISZW
e
methyclothiazide
2Ibandronic acidPhase 375
3vitamin dPhase 31463
4
Zoledronic acidPhase 3276118072-93-868740
Synonyms:
(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid
(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid
(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
(1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate
118072-93-8
2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid
2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid
AC-1092
AC1L2ACJ
AC1Q6RN3
AKOS005145739
Aclasta
BIDD:GT0292
BIDD:PXR0134
Bio-0112
Bisphosphonate 3
C088658
CGP 42'446
CGP 42446
CGP 42446A
CGP-42'446
CGP-42446
CHEBI:46557
CHEMBL924
CID68740
D08689
 
DB00399
FT-0082657
HMS2089O09
I06-0710
KS-1132
LS-181815
MolPort-002-885-874
MolPort-003-850-890
NCGC00159521-02
NCGC00159521-03
NSC721517
Novartis brand of zoledronic acid
Reclast
Reclast (TN)
S00092
S1314_Selleck
UNII-70HZ18PH24
ZOL
Zoledronate
Zoledronic acid
Zoledronic acid (INN)
Zoledronic acid [USAN:INN]
Zometa
Zometa (Novartis)
Zometa (TN)
Zometa Concentrate
Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid
[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
5Calcium, DietaryPhase 33529
6DiphosphonatesPhase 3369
7
Miconazoleapproved, investigationalPhase 2291222916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
8
Ketoconazoleapproved, investigationalPhase 217165277-42-147576, 3823
Synonyms:
(+)-Ketoconazole
(+-)-cis-1-Acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1- ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine
(+/-)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
(+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
65277-42-1
79156-75-5
AC-15957
AC1L9UG3
BIDD:GT0696
BIM-0050645.0001
BPBio1_000635
BRD-K29113274-001-03-6
BRN 4303081
BSPBio_000577
C26H28Cl2N4O4
CHEBI:48336
CHEMBL75
CID456201
CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE
CPD000058460
EINECS 265-667-4
EU-0100666
Extina
Fungarest
Fungoral
HMS1569M19
HMS2051A19
HMS2089N05
HSDB 7447
K 1003
K0045
K1003_SIGMA
KCZ
KS-1205
KTZ
KW-1414
KZ
Ketoconazol
Ketoconazole
Ketoconazole [USAN:INN:BAN:JAN]
Ketoconazolum
Ketodan
Ketoderm
Ketoisdin
Ketozole
 
LS-110149
Lopac0_000666
MLS000069784
MLS000758224
MLS001146934
MLS002207053
MLS002222255
MolPort-003-848-307
NCGC00025000-01
NCGC00025000-02
NCGC00025000-03
NCGC00025000-04
NCGC00025000-05
NCGC00025000-06
NCGC00025000-07
NCGC00025000-08
NCGC00025000-09
NSC 317629
NSC317629
Nizoral
Nizoral A-D
Nizoral a-D
Nizoral, Extina, Xolegel, Kuric, Ketoconazole
Orifungal M
Panfungol
Piperazine
Prestwick0_000389
Prestwick1_000389
Prestwick2_000389
Prestwick3_000389
Prestwick_744
R 41,400
R 41400
R-41400
R41,400
R41400
S1353_Selleck
SAM001246983
SID456469
SMR000058460
SPBio_002498
Tocris-1103
UC280_SIGMA
UPCMLD-DP138
UPCMLD-DP138:001
Xolegel
cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H- imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-ketoconazol
cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine
dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-piperazine
ketoconazole
9
Tranexamic Acidapproved1991197-18-85526
Synonyms:
08455_FLUKA
1197-17-7
1197-18-8
1ceb
3-14-00-00868 (Beilstein Handbook Reference)
4-(Aminomethyl)-Cyclohexanecarboxylic Acid
4-(Aminomethyl)cyclohexanecarboxylic acid
4-(aminomethyl)cyclohexane-1-carboxylic acid
857653_ALDRICH
A0236
AB00052260
AB1003647
AC-4687
AC1L1KJH
AC1Q50F3
AC1Q546D
AC1Q5U04
ALBB-006013
AMCA
AMCHA
AMH
AR-1F6595
Acide tranexamique
Acide tranexamique [INN-French]
Acido tranexamico
Acido tranexamico [INN-Spanish]
Acidum tranexamicum
Acidum tranexamicum [INN-Latin]
Amikapron
Amstat
Anvitoff
BAY 3517
BPBio1_000069
BRN 2207452
BSPBio_000061
BSPBio_002837
CAS-1197-18-8
CHEBI:48669
CHEMBL292500
CHEMBL877
CID5526
CL 65336
CL-65336
Carxamin
Cyclocapron
Cyklokapron
Cyklokapron (TN)
D01136
DB00302
DV 79
DV-79
DV79
DivK1c_000655
EINECS 214-818-2
Emorhalt
Exacyl
Frenolyse
HMS1568D03
HMS1921F08
HMS2092P03
HMS502A17
Hexapromin
Hexatron
I04-0993
IDI1_000655
KABI 2161
KBio1_000655
KBio2_001871
KBio2_004439
KBio2_007007
KBio3_002337
KBioGR_000511
KBioSS_001871
 
LS-56611
LS-56612
LT00159441
Lysteda
Mastop
MolPort-001-792-390
MolPort-002-512-008
NCGC00016569-01
NCGC00016569-02
NCGC00016569-03
NCGC00094944-01
NCGC00094944-02
NINDS_000655
NSC 291305
NSC291305
Oprea1_786414
Prestwick0_000171
Prestwick1_000171
Prestwick2_000171
Prestwick3_000171
Prestwick_476
RP 18,429
Rikavarin
Rikavarin (TN)
Rikavarin-S
SPBio_000689
SPBio_001982
SPECTRUM1502026
STK503668
STOCK1N-16183
Spectrum2_000655
Spectrum3_001189
Spectrum4_000046
Spectrum5_001258
Spectrum_001391
Spiramin
Tamcha
Tranex
Tranexamate
Tranexamic Acid
Tranexamic acid (JP15/USAN/INN)
Tranexamic acid [USAN:INN:BAN:JAN]
Tranexamic acid cis-form
Tranexamsaeure
Tranexan
Tranexmic acid
Tranhexamic acid
Trans AMCHA
Trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid
Trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid
Trans-p-(Aminomethyl)cyclohexanecarboxylic
Transamin
Transamin (TN)
Transamlon
Trasamlon
UNII-6T84R30KC1
Ugurol
WLN: L6TJ AVQ D1Z -T
cis-4-(Aminomethyl)cyclohexanecarboxylic acid
cis-4-Aminomethylcyclohexane-1-carboxylic acid
cis-AMCHA
t-AMCHA
tranexamic acid
tranexmic acid
trans-1-Aminomethylcyclohexane-4-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid
trans-4-(Aminomethyl)cyclohexane-carboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid
trans-4-(Aminomethyl)cyclohexanecarboxylic acid ester
trans-4-Aminomethylcyclohexane-1-carboxylic acid
trans-4-aminomethylcyclohexane-1-carboxylic acid
trans-Amcha
trans-Tranexamic acid
trans-p-(Aminomethyl)cyclohexanecarboxylic acid
10
Pamidronateapproved4240391-99-94674
Synonyms:
(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
(3-Amino-1-hydroxypropylidene)bisphosphonic acid
(3-Amino-1-hydroxypropylidene)diphosphonic acid
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid
(3-amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
(3-amino-1-hydroxypropylidene)-1,1-biphosphonate
(3-amino-1-hydroxypropylidene)-1,1-bisphosphonate
1-hydroxy-3-aminopropane-1,1-diphosphonic acid
3-Amino-1-hydroxypropylidene-1,1-diphosphonate
40391-99-9
57248-88-1
57248-88-1 (di-hydrochloride salt)
AC1L1IP4
AHPrBP
AKOS003599275
APD
Acide pamidronique
Acide pamidronique [INN-French]
Acido pamidronico
Acido pamidronico [INN-Spanish]
Acidum pamidronicum
Acidum pamidronicum [INN-Latin]
Amidronate
Aminomux
Aredia
BIDD:GT0538
Bisphosphonate 6
C019248
C07395
C3H11NO7P2
 
CHEMBL834
CID4674
ChemDiv1_025240
D07281
DB00282
EINECS 254-905-2
HMS2090C13
HMS658L06
HSCI1_000312
I14-2407
LS-174826
MolPort-002-131-054
NCGC00159433-02
NCGC00159433-03
Novartis brand of pamidronate disodium salt
PAMIDRONATE DISODIUM
PAMIDRONIC ACID
Pamidronate Disodium
Pamidronic acid
Pamidronic acid (INN)
Pamidronic acid [INN:BAN]
Ribodroat
Ribodroat (TN)
STOCK1N-12562
UNII-OYY3447OMC
amino-1-hydroxypropane-1,1-diphosphonate
aminohydroxypropylidene diphosphonate
aminopropanehydroxydiphosphonate
pamidronate
pamidronate calcium
pamidronate monosodium
11
Vitamin Eapproved, nutraceutical35059-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-alpha-tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'r)-alpha-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-alpha-tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitamin e
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
d-alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
12Coagulants983
13
Cobalt1477440-48-4104729
Synonyms:
Aquacat
Co
 
Cobalt-59
Cobatope-57
Kobalt
Super cobalt
14Tocotrienols352
15Tocopherols355
16
Chromium1197440-47-327668
Synonyms:
Chrome
 
Chromium metal
Cr
17TocopherolNutraceutical355
18TocotrienolNutraceutical352

Interventional clinical trials:

(show all 44)
idNameStatusNCT IDPhase
1Ultra-Short Anatomic and Conventional Cementless Stems Cementless Stems in Patients Younger Than Fifty-Five Years OldCompletedNCT02338596Phase 4
2A Randomised Single Centre Study to Compare the Long-Term Wear Characteristics of Marathon™ and Enduron™ Polyethylene Cup Liners in Primary Total Hip ReplacementActive, not recruitingNCT00208442Phase 4
3Efficacy of the CLP® Hip - RetrospectiveTerminatedNCT00764842Phase 4
4Multi-Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Resurfacing and Primary Total Hip ReplacementTerminatedNCT00872547Phase 4
5Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral HeadCompletedNCT00939900Phase 3
6Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled TrialCompletedNCT00532220Phase 3
7Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected SubjectsRecruitingNCT00172315Phase 3
8Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral HeadRecruitingNCT01892514Phase 3
9Trinity™ BIOLOX Delta™ CoC THR Multi-center StudyRecruitingNCT01921309Phase 3
10A Clinical Trial Study of Hip System in Primary Total Hip Arthroplasty in ChinaRecruitingNCT02399007Phase 3
11Project JAY THA Registration StudyActive, not recruitingNCT02347384Phase 3
12Implantation of Bone Marrow Cells to Treat Avascular Necrosis of Femoral Head (ANFH)Enrolling by invitationNCT01613612Phase 2, Phase 3
13A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip ReplacementTerminatedNCT00208468Phase 3
14Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee SurgeryCompletedNCT00393848Phase 2
15Evaluation of Mesenchymal Stem Cells to Treat Avascular Necrosis of the HipRecruitingNCT02065167Phase 2
16Mesenchymal Stem Cells in Osteonecrosis of the Femoral HeadRecruitingNCT01605383Phase 1, Phase 2
17Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral HeadActive, not recruitingNCT01643655Phase 1, Phase 2
18Autologous Bone Marrow Stem Cell Transplantation for Hip Osteonecrosis in Sickle Cell DiseaseEnrolling by invitationNCT02448121Phase 1, Phase 2
19Evaluate the Effect of Bone Marrow Derived Cd133+ Cells in Patient With Osteonecrosis of Femoral HeadCompletedNCT01198080Phase 1
20The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral HeadCompletedNCT02007915
21Rotational Thromboelastography Study in Tranexamic Acid and Colloid InfusionCompletedNCT02146456
22Selective Ultrasound Screening for DDH 1991-2006CompletedNCT01866527
23Safety and Effectiveness Study of the Reflection Ceramic Acetabular SystemCompletedNCT00663351
24Periprosthetic Bone Mineral Density After Total Hip Arthroplasty Performed Through a Minimally Invasive Anterior Approach (AMIS) With Either an AMIStem or a Quadra Femoral ComponentCompletedNCT01285843
25Molecular Genetic Study of Avascular Necrosis of the Femoral HeadRecruitingNCT00260897
26Tritanium® Study in JapanRecruitingNCT02552069
27Autologous Bone Marrow and BMP7 Treatment in the Necrosis in the Femoral Head of the AdultRecruitingNCT02655120
28Ceramic-on-Ceramic (COC) 36mm Acetabular Bearing Insert Post Approval Study-New Subjects (COC36mmPAS)RecruitingNCT02096211
2928mm Ceramic-on-Ceramic Total Hip Replacement StudyRecruitingNCT01657435
30Post Market Clinical Follow-up Study Protocol for PROFEMUR® Xm Femoral StemsRecruitingNCT02309593
31Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationRecruitingNCT02087449
32A Multi-centre, Prospective Surveillance to Assess Mid-term Performance of the Mpact CupRecruitingNCT02196818
33AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance StudyRecruitingNCT01107340
34Comparison of Hip Resurfacing to Large Femoral Head Total Hip ArthroplastyActive, not recruitingNCT00175487
35Ceramic On Ceramic (COC) 36mm PAS IDE Rollover Subjects; Ceramic Acetabular Bearing With Ceramic Femoral Head in Total Hip ReplacementActive, not recruitingNCT02096198
36A Study on M2a Magnum Total Hip ArthroplastyActive, not recruitingNCT01010763
37A Clinical Investigation of the C2a-Taper™ Acetabular SystemActive, not recruitingNCT00578851
38A Comparison of Two Different Surgical Techniques for Total Hip ResurfacingActive, not recruitingNCT00750984
39Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityActive, not recruitingNCT02087436
40Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator Cemented Femoral StemsEnrolling by invitationNCT02397746
41Post Market Clinical Follow-Up Study Protocol for PROFEMUR® TL Modular Femoral StemsEnrolling by invitationNCT02239783
42Post Market Clinical Follow-up Study Protocol for DYNASTY® BioFoam® Acetabular ComponentsEnrolling by invitationNCT02149667
43Treatment of Avascular Necrosis of the Femoral Head With Core Decompression Using the PerFuse Instrument and BioCUENot yet recruitingNCT02662881
44Avascular Necrosis (AVN) Long-Term Follow-upTerminatedNCT00833430

Search NIH Clinical Center for Avascular Necrosis of the Femoral Head

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Avascular Necrosis of the Femoral Head:
RNL-Astrostem
Embryonic/Adult Cultured Cells Related to Avascular Necrosis of the Femoral Head:
Adipose-derived mesenchymal stem cells , PMIDs: 21303266, 24341080

Genetic Tests for Avascular Necrosis of the Femoral Head

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Anatomical Context for Avascular Necrosis of the Femoral Head

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MalaCards organs/tissues related to Avascular Necrosis of the Femoral Head:

33
Bone, Endothelial, Bone marrow, Heart, Myeloid, Pituitary, Breast

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Avascular Necrosis of the Femoral Head:
id TissueAnatomical CompartmentCell Relevance
1 AdiposeSubcutaneous White AdiposeMesenchymal Stem Cells Potential therapeutic candidate
2 AdiposeSubcutaneous White AdiposeStromal Cells Potential therapeutic candidate

Animal Models for Avascular Necrosis of the Femoral Head or affiliated genes

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MGI Mouse Phenotypes related to Avascular Necrosis of the Femoral Head:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.8APOB, COL2A1, LEP, SOD1, SREBF2
2MP:00053857.8ABCB1, APOA1, APOB, COL2A1, LEP, SOD1
3MP:00053706.7ABCB1, APOA1, APOB, COL2A1, IGFBP3, LEP
4MP:00053766.5ABCB1, APOA1, APOB, CAT, IGFBP3, LEP

Publications for Avascular Necrosis of the Femoral Head

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Articles related to Avascular Necrosis of the Femoral Head:

(show top 50)    (show all 335)
idTitleAuthorsYear
1
Geometric analysis of an expandable reamer for treatment of avascular necrosis of the femoral head. (26185054)
2015
2
Cotransplantation of bone marrow mononuclear cells and umbilical cord mesenchymal stem cells in avascular necrosis of the femoral head. (24507042)
2014
3
A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg-CalvAc-Perthes disease or avascular necrosis of the femoral head. (24949742)
2014
4
MDR1 Gene Polymorphisms Are Associated with Glucocorticoid-Induced Avascular Necrosis of the Femoral Head in a Chinese Population. (24387690)
2014
5
Trabecular metal screw implanted for avascular necrosis of the femoral head may complicate subsequent arthroplasty surgery. (23860809)
2013
6
Long-term results of 32-mm alumina-on-alumina THA for avascular necrosis of the femoral head. (22249776)
2012
7
Association of sterol regulatory element binding protein 2 and insulin-like growth factor binding protein 3 genetic polymorphisms with avascular necrosis of the femoral head in the Chinese population. (23158139)
2012
8
Macroscopic and microscopic findings in avascular necrosis of the femoral head. (22990546)
2012
9
In brief: Ficat classification: avascular necrosis of the femoral head. (22760600)
2012
10
Genetic traits of avascular necrosis of the femoral head analyzed by array comparative genomic hybridization and real-time polymerase chain reaction. (21210629)
2011
11
Coincidence of avascular necrosis of the femoral head and unstable intertrochanteric fracture: is an extensively coated cementless revision stem a reasonable choice? (21206291)
2011
12
Avascular necrosis of the femoral head in patients with Hodgkin's disease. (21157752)
2010
13
Effect of antler extract on corticosteroid-induced avascular necrosis of the femoral head in rats. (19818844)
2010
14
Avascular necrosis of the femoral head following intramedullary nailing of the femur in a skeletally mature young adult: a case report. (18716697)
2008
15
Avascular necrosis of the femoral head in sickle cell disease in Nigeria: a retrospective study. (17767206)
2007
16
Avascular necrosis of the femoral head 8 years after posterior hip dislocation. (17316640)
2007
17
Avascular necrosis of the femoral head as the first manifestation of acute lymphoblastic leukemia. (16502568)
2006
18
Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head. (14765887)
2004
19
Deceptive low back pain and pseudoradicular signs in avascular necrosis of the femoral head. (17618211)
2004
20
Avascular necrosis of the femoral head in a HIV-1 infected patient receiving lopinavir/ritonavir. (14659664)
2003
21
Prognosis of early stage avascular necrosis of the femoral head. (9973986)
1999
22
Avascular necrosis of the femoral head after intertrochanteric fractures. (9892118)
1999
23
No link between avascular necrosis of the femoral head and antiphospholipid antibodies. (9513610)
1997
24
Avascular necrosis of the femoral head after intramedullary nailing of a femoral shaft fracture in a male adolescent. (9210128)
1997
25
Diagnostic patterns for bone marrow oedema syndrome and avascular necrosis of the femoral head in dynamic bone scintigraphy. (9481765)
1997
26
Is avascular necrosis of the femoral head the result of inhibition of angiogenesis? (9466372)
1997
27
Vascularized pedicle bone-grafting for nontraumatic avascular necrosis of the femoral head. A 5- to 11-year follow-up. (9177798)
1997
28
Vascularized iliac bone graft for avascular necrosis of the femoral head. (9137185)
1997
29
Long-term follow-up of avascular necrosis of the femoral head in the dog. (8642794)
1996
30
Non-traumatic avascular necrosis of the femoral head. (7890797)
1995
31
Diagnosis of avascular necrosis of the femoral head in patients treated for lymphoma. (7622143)
1995
32
Avascular necrosis of the femoral head after closed intramedullary shortening in an adolescent. (7883921)
1995
33
Imaging study on the mode of development and changes in avascular necrosis of the femoral head in systemic lupus erythematosus: long-term observations. (8156306)
1994
34
Transtrochanteric anterior rotational osteotomy for avascular necrosis of the femoral head. Long-term results. (8331115)
1993
35
Intertrochanteric osteotomy and autogenous bone-grafting for avascular necrosis of the femoral head. (8354670)
1993
36
Bipolar prosthetic replacement for the treatment of avascular necrosis of the femoral head. (1555332)
1992
37
Iliac periosteal graft with vascular pedicle in the treatment of avascular necrosis of the femoral head. Experimental study and clinical application. (1291204)
1992
38
Magnetic resonance imaging and scintigraphy of avascular necrosis of the femoral head. Prediction of subsequent segmental collapse. (1555357)
1992
39
Detection of acute avascular necrosis of the femoral head in dogs: dynamic contrast-enhanced MR imaging vs spin-echo and STIR sequences. (1442396)
1992
40
Natural history of nontraumatic avascular necrosis of the femoral head. (1991778)
1991
41
Core decompression for avascular necrosis of the femoral head: correlation between long-term results and preoperative MR staging. (2326478)
1990
42
Avascular necrosis of the femoral head. (2522435)
1989
43
Avascular necrosis of the femoral head: morphologic assessment by MR imaging, with CT correlation. (3786725)
1986
44
Avascular necrosis of the femoral head in sickle-cell disease. A series from the Guinea Savannah of Nigeria. (3968138)
1985
45
Consequences of avascular necrosis of the femoral head in aluminium-related renal osteodystrophy and the role of endochondral ossification in the repair process. (6402524)
1983
46
Haematological factors associated with avascular necrosis of the femoral head in homozygous sickle cell disease. (6173057)
1982
47
Corticosteroids and avascular necrosis of the femoral head in childhood. (1222002)
1975
48
Avascular necrosis of the femoral head in patients on chronic hemodialysis. (4610967)
1972
49
A histological study of avascular necrosis of the femoral head after transcervical fracture. (5846780)
1965
50
Avascular necrosis of the femoral head associated with sickle cell trait (AS hemoglobin). (14490507)
1962

Variations for Avascular Necrosis of the Femoral Head

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UniProtKB/Swiss-Prot genetic disease variations for Avascular Necrosis of the Femoral Head:

67
id Symbol AA change Variation ID SNP ID
1COL2A1p.Gly717SerVAR_023929
2COL2A1p.Gly1170SerVAR_023933

Expression for genes affiliated with Avascular Necrosis of the Femoral Head

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Search GEO for disease gene expression data for Avascular Necrosis of the Femoral Head.

Pathways for genes affiliated with Avascular Necrosis of the Femoral Head

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Pathways related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CAT, SOD1
2
Show member pathways
9.4ABCB1, CAT, SOD1
39.4ABCB1, CAT, IGFBP3
49.3APOA1, APOB
59.3APOA1, APOB
6
Show member pathways
9.2APOA1, CAT, SOD1
7
Show member pathways
9.0ABCB1, APOA1, APOB
8
Show member pathways
8.6APOA1, APOB, CAT, SOD1

GO Terms for genes affiliated with Avascular Necrosis of the Femoral Head

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Cellular components related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:003066910.1APOB, HLA-DRB1
2endocytic vesicle lumenGO:007168210.0APOA1, APOB
3chylomicronGO:004262710.0APOA1, APOB
4very-low-density lipoprotein particleGO:003436110.0APOA1, APOB
5ER to Golgi transport vesicle membraneGO:00125079.8HLA-DRB1, SREBF2
6endoplasmic reticulum lumenGO:00057889.1APOA1, APOB, COL2A1
7extracellular regionGO:00055767.6APOA1, APOB, COL2A1, IGFBP3, LEP, SOD1
8extracellular exosomeGO:00700627.4ABCB1, APOA1, APOB, CAT, HLA-DRB1, IGFBP3
9extracellular spaceGO:00056157.1APOA1, APOB, CAT, COL2A1, IGFBP3, LEP

Biological processes related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1response to reactive oxygen speciesGO:000030210.2CAT, SOD1
2response to vitamin EGO:003319710.0CAT, LEP
3positive regulation of cytokine productionGO:000181910.0LEP, SOD1
4lipoprotein biosynthetic processGO:004215810.0APOA1, APOB
5placenta developmentGO:00018909.9LEP, SOD1
6regulation of intestinal cholesterol absorptionGO:00303009.8APOA1, LEP
7cholesterol effluxGO:00333449.8APOA1, APOB
8lipoprotein metabolic processGO:00421579.8APOA1, APOB
9regulation of protein phosphorylationGO:00019329.8APOA1, LEP
10cholesterol transportGO:00303019.7APOA1, APOB
11protein tetramerizationGO:00512629.7CAT, HLA-DRB1
12triglyceride catabolic processGO:00194339.6APOA1, APOB
13positive regulation of cholesterol storageGO:00108869.5APOB, SREBF2
14response to drugGO:00424938.8ABCB1, APOA1, CAT, SOD1
15lipid metabolic processGO:00066298.7APOB, LEP, SREBF2
16cholesterol metabolic processGO:00082037.7APOA1, APOB, CAT, LEP, SREBF2

Molecular functions related to Avascular Necrosis of the Femoral Head according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:00171279.4APOA1, APOB
2lipid transporter activityGO:00053199.3APOA1, APOB

Sources for Avascular Necrosis of the Femoral Head

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet