MCID: AVN001
MIFTS: 55

Avian Influenza malady

Summaries for Avian Influenza

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Birds, just like people, get the flu. bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. most bird flu viruses can only infect other birds. however, bird flu can pose health risks to people. the first case of a bird flu virus infecting a person directly, h5n1, was in hong kong in 1997. since then, the bird flu virus has spread to birds in countries in asia, africa, the middle east, and europe. human infection is still very rare, but the virus that causes the infection in birds might change, or mutate, to more easily infect humans. this could lead to a pandemic, a worldwide outbreak of the illness. during an outbreak of bird flu, people who have contact with infected birds can become sick. it may also be possible to catch bird flu by eating poultry or eggs that are not well cooked or through contact with a person who has it. bird flu can make people very sick or even cause death. antiviral medicines may make the illness less severe, and may help prevent the flu in people who were exposed to it. there is currently no vaccine.

MalaCards: Avian Influenza, also known as bird flu, is related to influenza and newcastle disease, and has symptoms including acute respiratory distress, pneumonia and neurologic changes. An important gene associated with Avian Influenza is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Signal regulatory protein (SIRP) family interactions and Type II interferon signaling (IFNG). The compounds ribavirin and ccl3 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract of humans, t cells and testes, and related mouse phenotypes are respiratory system and nervous system.

Disease Ontology:8 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in influenza a virus, which is transmitted by contact with infected poultry. five strains of avian influenza a viruses (h5n1, h7n3, h7n2, h7n7 and h9n2) are known to cause human infections. the infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC:3 Information on Avian InfluenzaAvian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer information about avian influenza for different audiences.

Wikipedia:63 Avian influenza — known informally as avian flu or bird flu — refers to \"influenza caused by... more...

Aliases & Classifications for Avian Influenza

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

avian influenza 8 10
bird flu 8 33
influenza in birds 60
avian flu 8


External Ids:

Disease Ontology8 DOID:4492
SNOMED-CT56 55604004
MeSH34 D005585

Related Diseases for Avian Influenza

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17GeneCards, 18GeneDecks
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Diseases related to Avian Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1influenza32.2FURIN, IVNS1ABP, IFNB1, SFTPD, CXCL10, PTPN11
2newcastle disease31.3IVNS1ABP, NEU1, IFNB1, CXCL10
3severe acute respiratory syndrome30.5CXCL10
4vaccinia30.3FURIN
5encephalitis30.1CXCL10
6japanese encephalitis30.1PTPN11, IVNS1ABP
7swine influenza10.6
8laryngotracheitis10.4
9bronchitis10.3
10stomatitis10.3
11conjunctivitis10.2
12monkeypox10.1
13smallpox10.1
14cholera10.1
15adult respiratory distress syndrome10.1
16leptospirosis10.1
17acquired immunodeficiency syndrome10.1
18duodenitis10.1
19adult syndrome10.1
20malaria10.1
21pneumonia10.1
22tetanus10.1
23tularemia10.1
24mumps10.0NEU1
25thyroiditis10.0FASLG
26lung cancer10.0MAGEA3
27measles10.0IFNB1
28uveitis10.0CXCL10
29myeloid leukemia10.0PTPN11, NEU1
30dengue hemorrhagic fever10.0IVNS1ABP, PTPN11
31respiratory failure10.0NEU1, CXCL10, SFTPD
32neutropenia10.0CXCL10, IFNB1
33sarcoidosis10.0SFTPD, CXCL10
34arthropathy10.0CXCL10, IVNS1ABP
35graves' disease10.0CXCL10, FASLG
36glioblastoma multiforme10.0MAGEA3, FASLG, PTPN11
37idiopathic pulmonary fibrosis10.0FASLG, SFTPD, CXCL10
38dengue disease10.0IFNB1, IVNS1ABP, PTPN11, NEU1
39myeloma10.0CCR1, FASLG, NEU1
40hepatitis10.0IFNB1, FASLG, CXCL10
41allergic asthma10.0IFNB1, SFTPD, CCR1
42stomach cancer10.0IFNB1, FASLG, MAGEA3, PTPN11
43cystic fibrosis10.0FURIN, SFTPD
44hepatitis c10.0PTPN11, IFNB1, NEU1, CXCL10, IVNS1ABP
45encephalomyelitis10.0CCR1, IFNB1, FASLG, CXCL10
46tropical spastic paraparesis10.0IFNB1, FASLG
47hepatocellular carcinoma10.0FASLG, MAGEA3, CCR1, NEU1, IFNB1
48ovarian cancer10.0NEU1, FASLG, MAGEA3, FURIN, IFNB1, CCR1
49systemic lupus erythematosus10.0PTPN11, CXCL10, FASLG, IFNB1
50squamous cell carcinoma10.0MAGEA3, TMPRSS11A, FURIN, CRK, FASLG, NEU1

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to avian influenza

Clinical Features for Avian Influenza

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 10)
  • acute respiratory distress
  • pneumonia
  • neurologic changes
  • vomiting
  • diarrhea
  • nausea
  • muscle aches
  • sore throat
  • cough
  • fever

Drugs & Therapeutics for Avian Influenza

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Avian Influenza

Drug clinical trials:

Search ClinicalTrials for Avian Influenza

Search NIH Clinical Center for Avian Influenza

Search CenterWatch for Avian Influenza

Genetic Tests for Avian Influenza

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Anatomical Context for Avian Influenza

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Avian Influenza:

32
T cells, Testes, Lung, Trachea, B cells, Nk cells, Myeloid, Brain

FMA organs/tissues related to Avian Influenza:

14
Respiratory tract of humans

Animal Models for Avian Influenza or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Avian Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.0PTPN11, SCRIB, FASLG, SFTPD, CCR1
2MP:00036319.6SCRIB, NEU1, GRK1, PTPN11, FURIN
3MP:00053769.6CCR1, IFNB1, NEU1, IVNS1ABP, CXCL10, PTPN11
4MP:00028739.5FURIN, TMPRSS11A, TMPRSS13, PTPN11, CRK, FASLG
5MP:00053859.4CCR1, FASLG, CRK, NEU1, IVNS1ABP, CXCL10
6MP:00053879.2CCR1, SFTPD, IFNB1, FASLG, NEU1, RNF19B
7MP:00107689.2SCRIB, FASLG, SFTPD, CCR1, CRK, NEU1

Publications for Avian Influenza

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Sources:
50PubMed
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Articles related to Avian Influenza:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Emergence in China of human disease due to avian influenza A(H10N8) - Cause for concern? (24406432)
2014
2
Antigenic Mapping of the Hemagglutinin of an H9N2 Avian Influenza Virus Reveals Novel Critical Amino Acid Positions in Antigenic Sites. (24429369)
2014
3
Exposure to avian influenza H7N9 in farms and wet markets. (23664058)
2013
4
Avirulent Marek's disease virus type 1 strain 814 vectored vaccine expressing avian influenza (AI) virus H5 haemagglutinin induced better protection than turkey herpesvirus vectored AI vaccine. (23301062)
2013
5
Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. (23136954)
2013
6
Avian influenza: mixed infections and missing viruses. (23921843)
2013
7
An experimental model to analyse the risk of introduction of a duck-originated H5 low-pathogenic avian influenza virus in poultry through close contact and contaminative transmission. (24252718)
2013
8
Risk factors for the introduction of avian influenza virus in breeder duck flocks during the first 24 weeks of laying. (23941671)
2013
9
Emergence of avian influenza A(H7N9) virus causing severe human illness - China, February-April 2013. (23657113)
2013
10
Investigating a crow die-off in January-February 2011 during the introduction of a new clade of highly pathogenic avian influenza virus H5N1 into Bangladesh. (24081824)
2013
11
Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium. (23775183)
2013
12
Genetic and biological characterisation of an avian-like H1N2 swine influenza virus generated by reassortment of circulating avian-like H1N1 and H3N2 subtypes in Denmark. (24047399)
2013
13
Development and Evaluation of a SYBR Green-Based Real Time RT-PCR Assay for Detection of the Emerging Avian Influenza A (H7N9) Virus. (24278234)
2013
14
Antigenic and molecular characterization of avian influenza A(H9N2) viruses, Bangladesh. (23968540)
2013
15
Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness. (23638099)
2013
16
Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs. (23192525)
2013
17
Antibodies to H5 subtype avian influenza virus and Japanese encephalitis virus in northern pintails (Anas acuta) sampled in Japan. (24059097)
2013
18
Full Genome Sequence of a Natural Reassortant H9N2 Avian Influenza Virus Isolated from Domestic Ducks in Jiangsu Province, China. (23868123)
2013
19
Interventions for avian influenza A (H5N1) risk management in live bird market networks. (23650388)
2013
20
Spatial and temporal analysis of human infection with avian influenza A(H7N9) virus in China, 2013. (24300887)
2013
21
Antigenic analysis of H5N1 highly pathogenic avian influenza viruses circulating in Egypt (2006-2012). (24139721)
2013
22
A high diversity of eurasian lineage low pathogenicity avian influenza A viruses circulate among wild birds sampled in Egypt. (23874653)
2013
23
Genome Sequence of a Novel Reassortant H3N6 Avian Influenza Virus from Domestic Mallard Ducks in Eastern China. (23580714)
2013
24
Genome Sequences of an H5N1 Highly Pathogenic Avian Influenza Virus Isolated from Vaccinated Layers in China in 2012. (24265490)
2013
25
Genetic Diversity and Phylogenetic Analysis of Highly Pathogenic Avian Influenza (HPAI) H5N1 Viruses Circulating in Bangladesh from 2007-2011. (24125197)
2013
26
Replication of avian influenza viruses in equine tracheal epithelium but not in horses. (24224824)
2013
27
The PA and HA gene-mediated high viral load and intense innate immune response in the brain contribute to the high pathogenicity of H5N1 avian influenza virus in mallard ducks. (23926340)
2013
28
Early regulation of viral infection reduces inflammation and rescues mx-positive mice from lethal avian influenza infection. (23395090)
2013
29
Complete genome sequence of an H10N5 avian influenza virus isolated from pigs in central China. (23166264)
2012
30
Detection method for avian influenza viruses in water. (23412765)
2012
31
Chinese and global distribution of H9 subtype avian influenza viruses. (23285143)
2012
32
Progress in control of H5N1 highly pathogenic avian influenza and the future for eradication. (23402100)
2012
33
Double-stranded RNA-induced activation of activating protein-1 promoter is differentially regulated by the non-structural protein 1 of avian influenza A viruses. (22239235)
2012
34
Potential role of HPA axis and sympathetic nervous responses in depletion of B cells induced by H9N2 avian influenza virus infection. (23251416)
2012
35
The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions. (21849460)
2011
36
Coexpression of avian influenza virus H5 and N1 by recombinant Newcastle disease virus and the impact on immune response in chickens. (22017039)
2011
37
Avian influenza and Newcastle disease in three risk areas for H5N1 highly pathogenic avian influenza in Mali, 2007-2008. (22312986)
2011
38
Potent vesicular stomatitis virus-based avian influenza vaccines provide long-term sterilizing immunity against heterologous challenge. (20181720)
2010
39
Use of a tetanus toxoid marker to allow differentiation of infected from vaccinated poultry without affecting the efficacy of a H5N1 avian influenza virus vaccine. (21257485)
2010
40
Prior infection with an H1N1 swine influenza virus partially protects pigs against a low pathogenic H5N1 avian influenza virus. (19840669)
2009
41
Detection of mammalian virulence determinants in highly pathogenic avian influenza H5N1 viruses: multivariate analysis of published data. (19625397)
2009
42
Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: molecular epidemiology, ecology and the situation in China. (19687041)
2009
43
Influence of avian influenza virus NS1 protein on the expression of IP-10 in BEAS-2B cells]. (19031697)
2008
44
Genetic characterization of nonstructural genes of H5N1 avian influenza viruses isolated in Thailand in 2004-2005. (19058578)
2008
45
Development and validation of an anti-N3 indirect immunofluorescent antibody test to be used as a companion diagnostic test in the framework of a "DIVA" vaccination strategy for avian influenza infections in poultry. (16595309)
2006
46
Infection of human airway epithelium by human and avian strains of influenza a virus. (16873262)
2006
47
Evaluation of the ESPLINE INFLUENZA A&B-N Kit for the diagnosis of avian and swine influenza. (16365531)
2005
48
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. (11562490)
2001
49
The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye's syndrome. (10365363)
1999
50
Genetic analysis reveals that both haemagglutinin and neuraminidase determine the sensitivity of naturally occurring avian influenza viruses to zanamivir in vitro. (10544106)
1999

Genetic Variations for Avian Influenza

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Expression for genes affiliated with Avian Influenza

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Avian Influenza

Search GEO for disease gene expression data for Avian Influenza.

Pathways for genes affiliated with Avian Influenza

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Avian Influenza

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Avian Influenza according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1ribavirin44 49 1112.7NEU1
2ccl344 2811.3CCR1, IFNB1, CXCL10
3ccl444 2811.3CXCL10, IFNB1, CCR1
42,5-oligoadenylate4410.3IFNB1, CXCL10, OASL
5phytate4410.3IFNB1, GRK1
6rantes4410.3PTPN11, FASLG, IFNB1, CCR1
7tetracycline44 1111.3IFNB1, FASLG, PTPN11, FURIN
8ifn-alpha4410.3PTPN11, CXCL10, FASLG, IFNB1
9dexamethasone44 49 28 1113.2CCR1, SFTPD, IFNB1, FASLG
10endotoxin4410.2CXCL10, FASLG, IFNB1, SFTPD
11agar4410.2PTPN11, NEU1, CRK, FASLG
12cycloheximide4410.2CXCL10, FASLG, IFNB1
13heparin44 28 11 2413.0CCR1, IFNB1, FASLG, NEU1, FURIN
14phosphatidylinositol4410.0CCR1, SFTPD, FASLG, CRK, CXCL10, PTPN11
15polysaccharide4410.0NEU1, FASLG, IFNB1, SFTPD
16thymidine44 2411.0SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
17monosaccharide4410.0SFTPD, NEU1
18adenylate4410.0IFNB1, FASLG, IVNS1ABP, CXCL10, FURIN
19cysteine449.9CCR1, SFTPD, IFNB1, FASLG, NEU1, PTPN11
20alanine449.9CCR1, IFNB1, FASLG, CXCL10, PTPN11, FURIN
21serine449.9FURIN, CCR1, CRK, NEU1, GRK1, PTPN11
22glucose449.9SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
23cholesterol44 28 11 2412.8SFTPD, IFNB1, FASLG, CXCL10, FURIN
24oligonucleotide449.7PTPN11, MAGEA3, FASLG, IFNB1, SFTPD
25calcium44 49 11 2412.4FURIN, PTPN11, CXCL10, GRK1, FASLG, IFNB1

GO Terms for genes affiliated with Avian Influenza

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16Gene Ontology
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Biological processes related to Avian Influenza according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961510.0OASL, IVNS1ABP, IFNB1
2defense response to virusGO:0516079.9OASL, CXCL10, IFNB1, IFIT5
3type I interferon-mediated signaling pathwayGO:0603379.9IFNB1, PTPN11, OASL
4cytokine-mediated signaling pathwayGO:0192219.9OASL, PTPN11, IFNB1, CCR1
5innate immune responseGO:0450879.5PTPN11, CRK, IFNB1, IFIT5, SFTPD

Products for genes affiliated with Avian Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Avian Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet