MCID: AVN001
MIFTS: 55

Avian Influenza malady

Summaries for Avian Influenza

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Birds, just like people, get the flu. bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. most bird flu viruses can only infect other birds. however, bird flu can pose health risks to people. the first case of a bird flu virus infecting a person directly, h5n1, was in hong kong in 1997. since then, the bird flu virus has spread to birds in countries in asia, africa, the middle east, and europe. human infection is still very rare, but the virus that causes the infection in birds might change, or mutate, to more easily infect humans. this could lead to a pandemic, a worldwide outbreak of the illness. during an outbreak of bird flu, people who have contact with infected birds can become sick. it may also be possible to catch bird flu by eating poultry or eggs that are not well cooked or through contact with a person who has it. bird flu can make people very sick or even cause death. antiviral medicines may make the illness less severe, and may help prevent the flu in people who were exposed to it. there is currently no vaccine.

MalaCards: Avian Influenza, also known as bird flu, is related to influenza and newcastle disease, and has symptoms including acute respiratory distress, pneumonia and neurologic changes. An important gene associated with Avian Influenza is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Signal regulatory protein (SIRP) family interactions and Type II interferon signaling (IFNG). The compounds ribavirin and ccl3 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract of humans, t cells and testes, and related mouse phenotypes are respiratory system and nervous system.

Disease Ontology:8 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in influenza a virus, which is transmitted by contact with infected poultry. five strains of avian influenza a viruses (h5n1, h7n3, h7n2, h7n7 and h9n2) are known to cause human infections. the infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC:3 Information on Avian InfluenzaAvian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer information about avian influenza for different audiences.

Wikipedia:63 Avian influenza — known informally as avian flu or bird flu — refers to \"influenza caused by... more...

Aliases & Classifications for Avian Influenza

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8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

avian influenza 8 10
bird flu 8 33
influenza in birds 60
avian flu 8


External Ids:

Disease Ontology8 DOID:4492
SNOMED-CT56 55604004
MeSH34 D005585

Related Diseases for Avian Influenza

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17GeneCards, 18GeneDecks
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Diseases related to Avian Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1influenza32.2FURIN, IVNS1ABP, IFNB1, SFTPD, CXCL10, PTPN11
2newcastle disease31.3IVNS1ABP, NEU1, IFNB1, CXCL10
3severe acute respiratory syndrome30.5CXCL10
4vaccinia30.3FURIN
5encephalitis30.1CXCL10
6japanese encephalitis30.1PTPN11, IVNS1ABP
7swine influenza10.6
8laryngotracheitis10.4
9bronchitis10.3
10stomatitis10.3
11conjunctivitis10.2
12monkeypox10.1
13smallpox10.1
14cholera10.1
15adult respiratory distress syndrome10.1
16leptospirosis10.1
17acquired immunodeficiency syndrome10.1
18duodenitis10.1
19adult syndrome10.1
20malaria10.1
21pneumonia10.1
22tetanus10.1
23tularemia10.1
24mumps10.0NEU1
25thyroiditis10.0FASLG
26lung cancer10.0MAGEA3
27measles10.0IFNB1
28uveitis10.0CXCL10
29myeloid leukemia10.0PTPN11, NEU1
30dengue hemorrhagic fever10.0IVNS1ABP, PTPN11
31respiratory failure10.0NEU1, CXCL10, SFTPD
32neutropenia10.0CXCL10, IFNB1
33sarcoidosis10.0SFTPD, CXCL10
34arthropathy10.0CXCL10, IVNS1ABP
35graves' disease10.0CXCL10, FASLG
36glioblastoma multiforme10.0MAGEA3, FASLG, PTPN11
37idiopathic pulmonary fibrosis10.0FASLG, SFTPD, CXCL10
38dengue disease10.0IFNB1, IVNS1ABP, PTPN11, NEU1
39myeloma10.0CCR1, FASLG, NEU1
40hepatitis10.0IFNB1, FASLG, CXCL10
41allergic asthma10.0IFNB1, SFTPD, CCR1
42stomach cancer10.0IFNB1, FASLG, MAGEA3, PTPN11
43cystic fibrosis10.0FURIN, SFTPD
44hepatitis c10.0PTPN11, IFNB1, NEU1, CXCL10, IVNS1ABP
45encephalomyelitis10.0CCR1, IFNB1, FASLG, CXCL10
46tropical spastic paraparesis10.0IFNB1, FASLG
47hepatocellular carcinoma10.0FASLG, MAGEA3, CCR1, NEU1, IFNB1
48ovarian cancer10.0NEU1, FASLG, MAGEA3, FURIN, IFNB1, CCR1
49systemic lupus erythematosus10.0PTPN11, CXCL10, FASLG, IFNB1
50squamous cell carcinoma10.0MAGEA3, TMPRSS11A, FURIN, CRK, FASLG, NEU1

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to avian influenza

Clinical Features for Avian Influenza

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 10)
  • acute respiratory distress
  • pneumonia
  • neurologic changes
  • muscle aches
  • sore throat
  • vomiting
  • nausea
  • diarrhea
  • fever
  • cough

Drugs & Therapeutics for Avian Influenza

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Avian Influenza

Drug clinical trials:

Search ClinicalTrials for Avian Influenza

Search NIH Clinical Center for Avian Influenza

Search CenterWatch for Avian Influenza

Genetic Tests for Avian Influenza

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Anatomical Context for Avian Influenza

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Avian Influenza:

32
T cells, Testes, Lung, Trachea, Nk cells, B cells, Myeloid, Brain

FMA organs/tissues related to Avian Influenza:

14
Respiratory tract of humans

Animal Models for Avian Influenza or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Avian Influenza:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.0PTPN11, SCRIB, FASLG, SFTPD, CCR1
2MP:00036319.6SCRIB, NEU1, GRK1, PTPN11, FURIN
3MP:00053769.6CCR1, IFNB1, NEU1, IVNS1ABP, CXCL10, PTPN11
4MP:00028739.5FURIN, TMPRSS11A, TMPRSS13, PTPN11, CRK, FASLG
5MP:00053859.4CCR1, FASLG, CRK, NEU1, IVNS1ABP, CXCL10
6MP:00053879.2CCR1, SFTPD, IFNB1, FASLG, NEU1, RNF19B
7MP:00107689.2SCRIB, FASLG, SFTPD, CCR1, CRK, NEU1

Publications for Avian Influenza

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Sources:
50PubMed
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Articles related to Avian Influenza:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Effects of different polymerases of avian influenza viruses on the growth and pathogenicity of A/Puerto Rico/8/1934 (H1N1)-derived reassorted viruses. (24296300)
2014
2
Quantitative transmission characteristics of different H5 low pathogenic avian influenza viruses in Muscovy ducks. (24287046)
2014
3
Magnesium-Dependent RNA Binding to the PA Endonuclease Domain of the Avian Influenza Polymerase. (24404971)
2014
4
A model for the transfer of passive immunity against Newcastle disease and avian influenza in specific pathogen free chickens. (24397892)
2014
5
Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus. (23265247)
2013
6
Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9). (24091087)
2013
7
Evaluation of phenotypic markers in full genome sequences of avian influenza isolates from California. (23891310)
2013
8
Evaluation of a commercial ELISA for H5 low pathogenic avian influenza virus antibody detection in duck sera using Bayesian methods. (23727545)
2013
9
Impact of Avian Influenza on Village Poultry Production Globally. (24136383)
2013
10
A novel reassortant avian influenza A(H7N9) virus in China - what are the implications for Europe. (23594574)
2013
11
Preferential recognition of avian-like receptors in human influenza A H7N9 viruses. (24311689)
2013
12
Drugs against Avian Influenza A Virus: Design of Novel Sulfonate Inhibitors of Neuraminidase N1. (24001233)
2013
13
Optimal isolation control strategies and cost-effectiveness analysis of a two-strain avian influenza model. (23810937)
2013
14
Inactivation of goose parvovirus, avian influenza virus and phage by photocatalyst on polyethylen terephthalate film under light emitting diode (LED). (23535267)
2013
15
Minimizing the threat of pandemic emergence from avian influenza in poultry systems. (24341669)
2013
16
Multiplex nested RT-PCR for detecting avian influenza virus, infectious bronchitis virus and Newcastle disease virus. (23261801)
2013
17
Variation in the responses of wild species of duck, gull, and wader to inoculation with a wild-bird-origin H6N2 low pathogenicity avian influenza virus. (24283122)
2013
18
Experimental infection of bar-headed geese (Anser indicus) and ruddy shelducks (Tadorna ferruginea) with a clade 2.3.2 H5N1 highly pathogenic avian influenza virus. (23735616)
2013
19
Biological features of novel avian influenza A (H7N9) virus. (23823727)
2013
20
Clinical, virological, and histopathological manifestations of fatal human infections by avian influenza A(H7N9) virus. (23943822)
2013
21
The Effectiveness of Preventative Mass Vaccination Regimes Against the Incidence of Highly Pathogenic Avian Influenza on Java Island, Indonesia. (23702277)
2013
22
Risk assessment on the epidemics of human infection with a novel avian influenza A (H7N9) virus in Jiangsu Province, China. (23720670)
2013
23
Survey for highly pathogenic avian influenza from poultry in two northeastern States, Nigeria. (23936731)
2013
24
Monitoring avian influenza A(H7N9) virus through national influenza-like illness surveillance, China. (23879887)
2013
25
Mapping spread and risk of avian influenza A (H7N9) in China. (24072008)
2013
26
Specific detection by real-time reverse-transcription PCR assays of a novel avian influenza A(H7N9) strain associated with human spillover infections in China. (23611031)
2013
27
Complete Genome Sequence of an H12N8 Avian Influenza Virus Isolated from Wild Bird Feces in Hunan East Dongting Lake National Nature Reserve. (24158557)
2013
28
Recombinant duck enteritis virus expressing the HA gene from goose H5 subtype avian influenza virus. (24144474)
2013
29
Avian influenza A(H7N9): information-sharing through government web sites in the Western Pacific Region. (24015371)
2013
30
Avian influenza. H5N1 researchers ready as moratorium nears end. (23288516)
2013
31
Antibody survey on avian influenza viruses using egg yolks of ducks in Hanoi between 2010 and 2012. (23849095)
2013
32
Intraocular vaccination with an inactivated highly pathogenic avian influenza virus induces protective antibody responses in chickens. (23159237)
2013
33
Accumulation and inactivation of avian influenza virus by the filter-feeding invertebrate Daphnia magna. (24038705)
2013
34
Assembly and immunological properties of a bivalent virus-like particle (VLP) for avian influenza and Newcastle disease. (24050994)
2013
35
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
36
Receptor specificity and erythrocyte binding preferences of avian influenza viruses isolated from India. (23110802)
2012
37
A low-pathogenic avian influenza H6N1 outbreak in a turkey flock in France: a comprehensive case report. (23237370)
2012
38
Evaluation of four enzyme-linked immunosorbent assays for the serologic survey of avian influenza in wild bird species. (23402117)
2012
39
Electronic microarray assays for avian influenza and Newcastle disease virus. (22796283)
2012
40
A National Survey of Emergency Nurses and Avian Influenza Threat. (23099013)
2012
41
Complete genome sequence of an avian-like H4N8 swine influenza virus discovered in southern China. (22879613)
2012
42
Thermal inactivation of avian influenza virus and Newcastle disease virus in a fat-free egg product. (21740719)
2011
43
Platycodin d improves the immunogenicity of newcastle disease virus-based recombinant avian influenza vaccine in mice. (20232336)
2010
44
Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication. (20219906)
2010
45
Inhibition of highly pathogenic avian H5N1 influenza virus replication by RNA oligonucleotides targeting NS1 gene. (17996729)
2008
46
Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. (18199656)
2008
47
Thermal inactivation of avian influenza and Newcastle disease viruses in chicken meat. (18592748)
2008
48
Avian influenza: a new pandemic threat? (15065617)
2004
49
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes. (11867515)
2002
50
Avian cells expressing the murine Mx1 protein are resistant to influenza virus infection. (1989389)
1991

Genetic Variations for Avian Influenza

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Expression for genes affiliated with Avian Influenza

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Avian Influenza

Search GEO for disease gene expression data for Avian Influenza.

Pathways for genes affiliated with Avian Influenza

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Avian Influenza

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Avian Influenza according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1ribavirin44 49 1112.7NEU1
2ccl344 2811.3CCR1, IFNB1, CXCL10
3ccl444 2811.3CXCL10, IFNB1, CCR1
42,5-oligoadenylate4410.3IFNB1, CXCL10, OASL
5phytate4410.3IFNB1, GRK1
6rantes4410.3PTPN11, FASLG, IFNB1, CCR1
7tetracycline44 1111.3IFNB1, FASLG, PTPN11, FURIN
8ifn-alpha4410.3PTPN11, CXCL10, FASLG, IFNB1
9dexamethasone44 49 28 1113.2CCR1, SFTPD, IFNB1, FASLG
10endotoxin4410.2CXCL10, FASLG, IFNB1, SFTPD
11agar4410.2PTPN11, NEU1, CRK, FASLG
12cycloheximide4410.2CXCL10, FASLG, IFNB1
13heparin44 28 11 2413.0CCR1, IFNB1, FASLG, NEU1, FURIN
14phosphatidylinositol4410.0CCR1, SFTPD, FASLG, CRK, CXCL10, PTPN11
15polysaccharide4410.0NEU1, FASLG, IFNB1, SFTPD
16thymidine44 2411.0SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
17monosaccharide4410.0SFTPD, NEU1
18adenylate4410.0IFNB1, FASLG, IVNS1ABP, CXCL10, FURIN
19cysteine449.9CCR1, SFTPD, IFNB1, FASLG, NEU1, PTPN11
20alanine449.9CCR1, IFNB1, FASLG, CXCL10, PTPN11, FURIN
21serine449.9FURIN, CCR1, CRK, NEU1, GRK1, PTPN11
22glucose449.9SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
23cholesterol44 28 11 2412.8SFTPD, IFNB1, FASLG, CXCL10, FURIN
24oligonucleotide449.7PTPN11, MAGEA3, FASLG, IFNB1, SFTPD
25calcium44 49 11 2412.4FURIN, PTPN11, CXCL10, GRK1, FASLG, IFNB1

GO Terms for genes affiliated with Avian Influenza

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16Gene Ontology
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Biological processes related to Avian Influenza according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961510.0IFNB1, IVNS1ABP, OASL
2defense response to virusGO:0516079.9OASL, CXCL10, IFNB1, IFIT5
3type I interferon-mediated signaling pathwayGO:0603379.9OASL, PTPN11, IFNB1
4cytokine-mediated signaling pathwayGO:0192219.9CCR1, IFNB1, PTPN11, OASL
5innate immune responseGO:0450879.5SFTPD, IFIT5, IFNB1, CRK, PTPN11

Products for genes affiliated with Avian Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Avian Influenza

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet