MCID: AVN001
MIFTS: 54

Avian Influenza malady

Summaries for Avian Influenza

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Birds, just like people, get the flu. bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. most bird flu viruses can only infect other birds. however, bird flu can pose health risks to people. the first case of a bird flu virus infecting a person directly, h5n1, was in hong kong in 1997. since then, the bird flu virus has spread to birds in countries in asia, africa, the middle east, and europe. human infection is still very rare, but the virus that causes the infection in birds might change, or mutate, to more easily infect humans. this could lead to a pandemic, a worldwide outbreak of the illness. during an outbreak of bird flu, people who have contact with infected birds can become sick. it may also be possible to catch bird flu by eating poultry or eggs that are not well cooked or through contact with a person who has it. bird flu can make people very sick or even cause death. antiviral medicines may make the illness less severe, and may help prevent the flu in people who were exposed to it. there is currently no vaccine.

MalaCards: Avian Influenza, also known as bird flu, is related to newcastle disease and severe acute respiratory syndrome, and has symptoms including cough, fever and diarrhea. An important gene associated with Avian Influenza is NEU1 (sialidase 1 (lysosomal sialidase)), and among its related pathways are Signal regulatory protein (SIRP) family interactions and Type II interferon signaling (IFNG). The compounds ribavirin and ccl3 have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract of humans, brain and lung, and related mouse phenotypes are respiratory system and nervous system.

Disease Ontology:8 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in influenza a virus, which is transmitted by contact with infected poultry. five strains of avian influenza a viruses (h5n1, h7n3, h7n2, h7n7 and h9n2) are known to cause human infections. the infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC:3 Avian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer information about avian influenza for different audiences.

Wikipedia:64 Avian influenza — known informally as avian flu or bird flu — refers to \"influenza caused by... more...

Aliases & Classifications for Avian Influenza

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

avian influenza 8 10
bird flu 8 34
influenza in birds 61
avian flu 8


External Ids:

Disease Ontology8 DOID:4492
SNOMED-CT57 55604004
MeSH35 D005585

Related Diseases for Avian Influenza

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Avian Influenza via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1newcastle disease31.4IFNB1, NEU1, IVNS1ABP, CXCL10
2severe acute respiratory syndrome30.6CXCL10
3vaccinia30.4FURIN
4japanese encephalitis30.1PTPN11, IVNS1ABP
5swine influenza10.6
6influenza, severe10.5
7laryngotracheitis10.4
8bronchitis10.3
9stomatitis10.3
10n syndrome10.3
11monkeypox10.2
12smallpox10.2
13reye syndrome10.1
14cholera10.1
15adult respiratory distress syndrome10.1
16leptospirosis10.1
17pinta disease10.1
18acquired immunodeficiency syndrome10.1
19adult syndrome10.1
20tetanus10.1
21tularemia10.1
22marek disease10.1
23encephalitis10.0CXCL10
24mumps10.0NEU1
25thyroiditis10.0FASLG
26lung cancer10.0MAGEA3
27measles10.0IFNB1
28uveitis10.0CXCL10
29myeloid leukemia10.0PTPN11, NEU1
30dengue hemorrhagic fever10.0PTPN11, IVNS1ABP
31respiratory failure10.0SFTPD, NEU1, CXCL10
32neutropenia10.0CXCL10, IFNB1
33sarcoidosis10.0CXCL10, SFTPD
34arthropathy10.0IVNS1ABP, CXCL10
35graves' disease10.0CXCL10, FASLG
36glioblastoma multiforme10.0PTPN11, MAGEA3, FASLG
37idiopathic pulmonary fibrosis10.0SFTPD, FASLG, CXCL10
38dengue disease10.0PTPN11, IVNS1ABP, NEU1, IFNB1
39myeloma10.0CCR1, FASLG, NEU1
40hepatitis10.0IFNB1, FASLG, CXCL10
41allergic asthma10.0CCR1, SFTPD, IFNB1
42stomach cancer10.0IFNB1, FASLG, MAGEA3, PTPN11
43cystic fibrosis10.0FURIN, SFTPD
44hepatitis c10.0IFNB1, NEU1, IVNS1ABP, CXCL10, PTPN11
45encephalomyelitis10.0CCR1, IFNB1, FASLG, CXCL10
46tropical spastic paraparesis10.0FASLG, IFNB1
47hepatocellular carcinoma10.0CCR1, IFNB1, FASLG, NEU1, MAGEA3
48ovarian cancer10.0CCR1, IFNB1, FASLG, NEU1, MAGEA3, FURIN
49systemic lupus erythematosus10.0IFNB1, FASLG, CXCL10, PTPN11
50squamous cell carcinoma10.0FASLG, CRK, NEU1, MAGEA3, TMPRSS11A, FURIN

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to avian influenza

Clinical Features for Avian Influenza

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 10)
  • cough
  • fever
  • diarrhea
  • nausea
  • vomiting
  • sore throat
  • muscle aches
  • neurologic changes
  • pneumonia
  • acute respiratory distress

Drugs & Therapeutics for Avian Influenza

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Avian Influenza

Drug clinical trials:

Search ClinicalTrials for Avian Influenza

Search NIH Clinical Center for Avian Influenza

Search CenterWatch for Avian Influenza

Genetic Tests for Avian Influenza

Anatomical Context for Avian Influenza

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Avian Influenza:

33
Brain, Lung, Whole blood, Myeloid, Nk cells, T cells, B cells, Trachea, Bronchial epithelium

FMA organs/tissues related to Avian Influenza:

14
Respiratory tract of humans

Animal Models for Avian Influenza or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Avian Influenza

Sources:
51PubMed
See all sources

Articles related to Avian Influenza:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Pre-Existing Cross-Reactive Antibodies to Avian Influenza H5N1 and 2009 Pandemic H1N1 in US Military Personnel. (24277784)
2014
2
Emergence of the Virulence-Associated PB2 E627K Substitution in a Fatal Human Case of Highly Pathogenic Avian Influenza Virus A(H7N7) Infection as Determined by Illumina Ultra-Deep Sequencing. (24257603)
2014
3
Discover binding pathways using the sliding binding-box docking approach: application to binding pathways of oseltamivir to avian influenza H5N1 neuraminidase. (23979194)
2013
4
Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China. (23614499)
2013
5
Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-I^ T cell responses in humans. (23357198)
2013
6
Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice. (23842497)
2013
7
Seroprevalence of avian influenza (H9N2) in broiler chickens in Northwest of Iran. (24075349)
2013
8
Genetic Analysis of an H5N2 Highly Pathogenic Avian Influenza Virus Isolated from a Chicken in a Live Bird Market in Northern Vietnam in 2012. (23986117)
2013
9
Rapid reassortment of internal genes in avian influenza A(H7N9) virus. (23788242)
2013
10
Avian-origin H3N2 canine influenza virus circulating in farmed dogs in Guangdong, China. (24298574)
2013
11
Sensitive and direct detection of receptor binding specificity of highly pathogenic avian influenza a virus in clinical samples. (24205123)
2013
12
Management of the First Confirmed Case of avian Influenza A H7N9. (24046465)
2013
13
An enzyme-linked immunosorbent assay for detection of avian influenza virus subtypes H5 and H7 antibodies. (24256721)
2013
14
Selection and characterization of DNA aptamers for use in detection of avian influenza virus H5N1. (23523887)
2013
15
Chimaeric VP2 proteins from infectious bursal disease virus containing the N-terminal M2e of H9 subtype avian influenza virus induce neutralizing antibody responses to both viruses. (23607544)
2013
16
Heterologous prime-boost immunization regimens using adenovirus vector and virus-like particles induce broadly neutralizing antibodies against H5N1 avian influenza viruses. (23813782)
2013
17
Protection of Chinese painted quails (Coturnix chinensis) against a highly pathogenic H5N1 avian influenza virus strain after vaccination. (23771736)
2013
18
Modulation of Humoral and Cell-Mediated Immunity Against Avian Influenza and Newcastle Disease Vaccines by Oral Administration of Salmonella enterica Serovar Typhimurium Expressing Chicken Interleukin-18. (23559899)
2013
19
Avian influenza A (H5N1) virus antibodies in pigs and residents of swine farms, southern China. (24231290)
2013
20
Historical prevalence and distribution of avian influenza virus A(H7N9) among wild birds. (24274638)
2013
21
Passive antibody transfer in chickens to model maternal antibody after avian influenza vaccination. (23398721)
2013
22
Molecular and epidemiological characterization of avian influenza viruses from gulls and dabbling ducks in Norway. (23575317)
2013
23
Serological surveillance of H5 and H9 avian influenza A viral infections among pigs in Southern China. (23973737)
2013
24
Avian influenza infection alters fecal odor in mallards. (24146753)
2013
25
World watching as troubling new type of avian influenza surfaces in China. (23630241)
2013
26
Highly pathogenic avian influenza virus nucleoprotein interacts with TREX complex adaptor protein Aly/REF. (24073193)
2013
27
Protection against H7N3 high pathogenicity avian influenza in chickens immunized with a recombinant fowlpox and an inactivated avian influenza vaccines. (23707445)
2013
28
The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice. (23255810)
2013
29
Complete Genomic Sequence of a Novel Reassortant H4N2 Avian Influenza Virus Isolated from Domestic Ducks in Jiangsu, China. (23516214)
2013
30
Investigation on the source of infection regarding an avian influenza (H7N9) in Changxing, Zhejiang province. (24147291)
2013
31
Human infections with avian influenza A(H7N9) virus in China: preliminary assessments of the age and sex distribution. (24015363)
2013
32
Social network analysis used to assess the relationship between the spread of avian influenza and movement patterns of backyard chickens in Ratchaburi, Thailand. (23528640)
2013
33
Host restrictions of avian influenza viruses: in silico analysis of H13 and H16 specific signatures in the internal proteins. (23646204)
2013
34
Avian influenza A(H7N9) and the closure of live bird markets. (24015364)
2013
35
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers. (23155008)
2012
36
Surveillance for avian influenza and Newcastle disease in backyard poultry flocks in CA'te d'Ivoire, 2007-2009. (23520736)
2012
37
Avian influenza and animal health risk: conservation of endemic threatened wild birds in Sardinia Island. (23402132)
2012
38
Prior infection of chickens with H1N1 or H1N2 avian influenza elicits partial heterologous protection against highly pathogenic H5N1. (23240067)
2012
39
Avian influenza virus wild bird surveillance in the Azov and Black Sea regions of Ukraine (2010-2011). (23402128)
2012
40
Genetic Analysis of Avian Influenza Viruses: Cocirculation of Avian Influenza Viruses with Allele A and B Nonstructural Gene in Northern Pintail (Anas acuta) Ducks Wintering in Japan. (23320157)
2012
41
Identification and characterization of H2N3 avian influenza virus from backyard poultry and comparison with novel H2N3 swine influenza virus. (22312981)
2011
42
Enhanced reliability of avian influenza virus (AIV) and Newcastle disease virus (NDV) identification using matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). (21294514)
2011
43
CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses. (20088952)
2010
44
Emergence of European avian influenza virus-like H1N1 swine influenza A viruses in China. (19553585)
2009
45
DC-SIGN mediates avian H5N1 influenza virus infection in cis and in trans. (18593570)
2008
46
Generation and evaluation of the trivalent inactivated reassortant vaccine using human, avian, and swine influenza A viruses. (18448208)
2008
47
Human parainfluenza viruses hPIV1 and hPIV3 bind oligosaccharides with alpha2-3-linked sialic acids that are distinct from those bound by H5 avian influenza virus hemagglutinin. (17522226)
2007
48
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
2006
49
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. (16051807)
2005
50
Efficient expression of the tumor-associated antigen MAGE-3 in human dendritic cells, using an avian influenza virus vector. (11084678)
2000

Genetic Variations for Avian Influenza

Expression for genes affiliated with Avian Influenza

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Avian Influenza

Search GEO for disease gene expression data for Avian Influenza.

Pathways for genes affiliated with Avian Influenza

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore
See all sources

Compounds for genes affiliated with Avian Influenza

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
See all sources

Compounds related to Avian Influenza according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1ribavirin45 50 1112.7NEU1
2ccl345 2911.3CCR1, IFNB1, CXCL10
3ccl445 2911.3CXCL10, IFNB1, CCR1
42,5-oligoadenylate4510.3IFNB1, CXCL10, OASL
5phytate4510.3IFNB1, GRK1
6rantes4510.3PTPN11, FASLG, IFNB1, CCR1
7tetracycline45 1111.3IFNB1, FASLG, PTPN11, FURIN
8ifn-alpha4510.3PTPN11, CXCL10, FASLG, IFNB1
9dexamethasone45 50 29 1113.2CCR1, SFTPD, IFNB1, FASLG
10endotoxin4510.2CXCL10, FASLG, IFNB1, SFTPD
11agar4510.2PTPN11, NEU1, CRK, FASLG
12cycloheximide4510.2CXCL10, FASLG, IFNB1
13heparin45 29 11 2413.0CCR1, IFNB1, FASLG, NEU1, FURIN
14phosphatidylinositol4510.0CCR1, SFTPD, FASLG, CRK, CXCL10, PTPN11
15polysaccharide4510.0NEU1, FASLG, IFNB1, SFTPD
16thymidine45 2411.0SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
17monosaccharide4510.0SFTPD, NEU1
18adenylate4510.0IFNB1, FASLG, IVNS1ABP, CXCL10, FURIN
19cysteine459.9CCR1, SFTPD, IFNB1, FASLG, NEU1, PTPN11
20alanine459.9CCR1, IFNB1, FASLG, CXCL10, PTPN11, FURIN
21serine459.9FURIN, CCR1, CRK, NEU1, GRK1, PTPN11
22glucose459.9SFTPD, IFNB1, FASLG, CRK, CXCL10, PTPN11
23cholesterol45 29 11 2412.8SFTPD, IFNB1, FASLG, CXCL10, FURIN
24oligonucleotide459.7PTPN11, MAGEA3, FASLG, IFNB1, SFTPD
25calcium45 50 11 2412.4FURIN, PTPN11, CXCL10, GRK1, FASLG, IFNB1

GO Terms for genes affiliated with Avian Influenza

Sources:
16Gene Ontology
See all sources

Biological processes related to Avian Influenza according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to virusGO:00961510.0OASL, IVNS1ABP, IFNB1
2defense response to virusGO:0516079.9OASL, CXCL10, IFNB1, IFIT5
3type I interferon-mediated signaling pathwayGO:0603379.9IFNB1, PTPN11, OASL
4cytokine-mediated signaling pathwayGO:0192219.9OASL, PTPN11, IFNB1, CCR1
5innate immune responseGO:0450879.5PTPN11, CRK, IFNB1, IFIT5, SFTPD

Products for genes affiliated with Avian Influenza

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Avian Influenza

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet