MCID: AVN001
MIFTS: 54

Avian Influenza malady

Categories: Respiratory diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Avian Influenza

Aliases & Descriptions for Avian Influenza:

Name: Avian Influenza 12 56 3 14
Bird Flu 12 41 3
Influenza in Birds 42 69
Avian Flu 12

Characteristics:

Orphanet epidemiological data:

56
avian influenza
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

Disease Ontology 12 DOID:4492
ICD10 33 J09.X
MeSH 42 D005585
SNOMED-CT 64 55604004
Orphanet 56 ORPHA454836
ICD10 via Orphanet 34 J09
UMLS 69 C0016627

Summaries for Avian Influenza

MedlinePlus : 41 birds, just like people, get the flu. bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. usually bird flu viruses only infect other birds. it is rare for people to get infected with bird flu viruses, but it can happen. two types, h5n1 and h7n9, have infected some people during outbreaks in asia, africa, the pacific, the middle east, and parts of europe. there have also been some rare cases of other types of bird flu affecting people in the united states. most of the people who get bird flu have had close contact with infected birds or with surfaces that have been contaminated by the birds' saliva, mucous, or droppings. it is also possible to get it by breathing in droplets or dust that contain the virus. rarely, the virus has spread from one person to another. it may also be possible to catch bird flu by eating poultry or eggs that are not well cooked. bird flu illness in people can range from mild to severe. often, the symptoms are similar to the seasonal flu, such as fever cough sore throat runny or stuffy nose muscle or body aches fatigue headaches eye redness (or conjunctivitis) difficulty breathing in some cases, bird flu can cause serious complications and death. as with seasonal flu, some people are at higher risk for serious illness. they include pregnant women, people with weakened immune systems, and seniors aged 65 and older. treatment with antiviral medicines may make the illness less severe. they may also help prevent the flu in people who were exposed to it. there is currently no vaccine available to the public. the government does have a supply of a vaccine for one type of h5n1 bird flu virus and could distribute it if there was an outbreak that spread easily from person to person. centers for disease control and prevention

MalaCards based summary : Avian Influenza, also known as bird flu, is related to severe acute respiratory syndrome and influenza, and has symptoms including fever, cough and sore throat. An important gene associated with Avian Influenza is FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Vaccines and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system

Disease Ontology : 12 An influenza that results_in infection located in respiratory tract of humans, domestic and wild birds, has material basis in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC : 3 Avian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer more information about avian influenza.

Wikipedia : 71 Avian influenza — known informally as avian flu or bird flu — refers to \"influenza caused by... more...

Related Diseases for Avian Influenza

Diseases related to Avian Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 29.7 DDX58 IFNA1 IRF7 NEU1
2 influenza 11.1
3 newcastle disease 10.5
4 sexual masochism 10.0 CXCL10 DDX58 TNF
5 plantar fasciitis 10.0 CXCL10 DDX58 SCRIB
6 selective igm deficiency disease 10.0 HAS1 NEU1 TNF
7 swine influenza 10.0
8 bronchitis 10.0
9 laryngotracheitis 9.9
10 drug dependence 9.9 IFNA1 TNF
11 mucositis 9.9
12 vaccinia 9.9
13 stomatitis 9.9
14 hyperimmunoglobulin syndrome 9.8 CXCL10 IFNA1 TNF
15 senile cataract 9.8 DDX58 IFNA1 TNF
16 pneumonia 9.8
17 conjunctivitis 9.8
18 monkeypox 9.8
19 smallpox 9.8
20 complex regional pain syndrome 9.8 CXCL10 IFNA1 TNF
21 hereditary hemorrhagic telangiectasia 9.7 DDX58 IFNA1 IRF7 TNF
22 malaria 9.6
23 west nile virus 9.6
24 adult respiratory distress syndrome 9.6
25 alopecia 9.6
26 meningoencephalitis 9.6
27 japanese encephalitis 9.6
28 respiratory failure 9.6
29 chlamydia 9.6
30 tetanus 9.6
31 rift valley fever 9.6
32 cholera 9.6
33 cryptosporidiosis 9.6
34 tularemia 9.6
35 leptospirosis 9.6
36 acquired immunodeficiency syndrome 9.6
37 duodenitis 9.6
38 encephalitis 9.6
39 acute respiratory distress syndrome 9.6
40 hemorrhagic fever 9.6
41 exophthalmos 9.6 CXCL10 DDX58 IFNA1 IRF7 TNF
42 eczematous dermatitis of eyelid 9.6 CXCL10 DDX58 IFNA1 IRF7 TNF
43 gastroduodenitis 9.6 DDX58 IFNA1 STAT2
44 rheumatoid lung disease 9.5 CXCL10 DDX58 FURIN IFNA1 IRF7 TNF
45 central nervous system angiosarcoma 8.1 CRK CXCL10 DDX58 FURIN HAS1 IFNA1

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to Avian Influenza

Symptoms & Phenotypes for Avian Influenza

Symptoms:

12
  • fever
  • cough
  • sore throat
  • muscle aches
  • nausea
  • diarrhea
  • vomiting
  • neurologic changes
  • pneumonia
  • acute respiratory distress

UMLS symptoms related to Avian Influenza:


coughing, fever, pruritus, snoring

GenomeRNAi Phenotypes related to Avian Influenza according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.8 IFNA1 TMPRSS13
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.8 IFNA1 TMPRSS13 CXCL10 FURIN
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.8 CXCL10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-143 9.8 FURIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.8 FURIN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.8 FURIN
7 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.8 IFNA1 FURIN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.8 TMPRSS13
9 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.8 IFNA1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.8 TMPRSS13
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.8 FURIN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.8 TMPRSS13
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.8 IFNA1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.8 TMPRSS13
15 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.8 FURIN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.8 FURIN
17 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.8 CXCL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.8 IFNA1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.8 IFNA1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.8 FURIN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.8 CXCL10
22 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.8 IFNA1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.8 IFNA1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.8 IFNA1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.8 IFNA1

MGI Mouse Phenotypes related to Avian Influenza:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CRK CXCL10 FURIN NEU1 PCSK5 PCSK6
2 hematopoietic system MP:0005397 9.91 CXCL10 DDX58 FURIN IRF7 NEU1 PCSK5
3 digestive/alimentary MP:0005381 9.87 CRK DDX58 FURIN PCSK5 PCSK6 SCRIB
4 immune system MP:0005387 9.81 DDX58 FURIN IRF7 NEU1 PCSK5 SFTPD
5 mortality/aging MP:0010768 9.73 PCSK6 SCRIB SFTPD STAT2 TNF CRK
6 respiratory system MP:0005388 9.17 CRK NEU1 PCSK5 PCSK6 SCRIB SFTPD

Drugs & Therapeutics for Avian Influenza

Drugs for Avian Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 2,Phase 3,Phase 1
2
Formaldehyde Approved, Vet_approved Phase 2, Phase 3,Phase 1 50-00-0 712
3
Oseltamivir Approved Phase 2, Phase 3,Phase 1 204255-11-8, 196618-13-0 65028
4
Aluminum hydroxide Approved Phase 2, Phase 3,Phase 1 21645-51-2
5 Hemagglutinins Phase 3,Phase 1,Phase 2
6
Lactitol Phase 3,Phase 2,Phase 1 585-86-4 3871
7 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
8 Agglutinins Phase 3,Phase 1,Phase 2
9 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
10 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
11 Immunoglobulins Phase 3,Phase 2,Phase 1
12 Anti-Infective Agents Phase 2, Phase 3,Phase 1
13 Immunosuppressive Agents Phase 3
14 Laxatives Phase 3
15 MF59 oil emulsion Phase 3,Phase 2,Phase 1
16 Antibodies Phase 3,Phase 2,Phase 1
17 Antiviral Agents Phase 2, Phase 3,Phase 1
18 Cathartics Phase 3
19
Zanamivir Approved, Investigational Phase 2,Phase 1 139110-80-8 60855
20
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
21
Amantadine Approved Phase 2 768-94-5 2130
22 Adjuvants, Immunologic Phase 2,Phase 1
23 Antacids Phase 1, Phase 2
24 Anti-Ulcer Agents Phase 1, Phase 2
25 Aluminum sulfate Phase 2
26 Analgesics Phase 2
27 Neurotransmitter Agents Phase 2
28 Analgesics, Non-Narcotic Phase 2
29 Peripheral Nervous System Agents Phase 2
30 Dopamine Agents Phase 2
31 gamma-Globulins Phase 2
32 Immunoglobulins, Intravenous Phase 2
33 Rho(D) Immune Globulin Phase 2
34 Antiparkinson Agents Phase 2
35
Probenecid Approved Phase 1 57-66-9 4911
36
Peramivir Approved, Investigational Phase 1 229614-55-5, 330600-85-6 151164
37
Inulin Approved, Nutraceutical Phase 1 9005-80-5 24763
38 Anti-Bacterial Agents Phase 1
39 Renal Agents Phase 1
40 Antibiotics, Antitubercular Phase 1
41 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 212)
id Name Status NCT ID Phase
1 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
2 Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old Completed NCT01730378 Phase 4
3 The Immunogenicity and Safety of 2013-2014 Seasonal Trivalent Influenza Vaccine Completed NCT02269852 Phase 4
4 H5N1 Vaccine Study in Japanese Adults Completed NCT01382329 Phase 2, Phase 3
5 Monovalent H5N1 Vaccine GSK1557484A in Children 6 Months to < 18 Years of Age Completed NCT01310413 Phase 3
6 Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure Completed NCT01788228 Phase 3
7 Immunogenicity, Safety and Tolerability of Two Doses of FLUAD-H5N1 Influenza Vaccine in Adult and Elderly Subjects Completed NCT00434733 Phase 3
8 Phase 3 Study of a H5N1 Vaccine in Adults, Elderly and Specified Risk Groups Completed NCT00711295 Phase 3
9 Japanese Pediatric H5N1 Vaccine Study Completed NCT01911754 Phase 3
10 H5N1 Vaccine Study in Japanese Elderly Population Aged 65 Years and Older Completed NCT01774032 Phase 3
11 Phase 3 Immunogenicity and Safety Study of an Inactivated H5N1 Influenza Vaccine (Whole Virion, Vero Cell Derived) Completed NCT00462215 Phase 3
12 Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects Using Four Different Completed NCT00848029 Phase 3
13 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Immunosuppressive Conditions *aH5N1:Monovalent H5N1 Influenza Vaccine Completed NCT02107807 Phase 3
14 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed NCT00319098 Phase 3
15 Phase III Study to Evaluate the Immunogenicity and Safety of MG1109 in Healthy Adult Volunteers Completed NCT01987011 Phase 3
16 Immunogenicity & Safety of GSK's Influenza Vaccine 1557484A Given to Adults Aged ≥18 Years Completed NCT00616928 Phase 3
17 Safety, Tolerability and Immunogenicity of Two Doses of Adjuvanted Monovalent Influenza Vaccine Administered to Healthy Adult and Elderly Subjects Completed NCT00841763 Phase 3
18 A Study to Evaluate the Safety and Immunogenicity of a Prime-boost Schedule of GSK Biologicals' Influenza Vaccine in Children Completed NCT01379937 Phase 3
19 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Underlying Medical Conditions Completed NCT02091908 Phase 3
20 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed NCT00652743 Phase 3
21 Immunogenicity and Safety of an Adjuvanted Inactivated Subunit Influenza Vaccine to Those of a Non-adjuvanted Inactivated Subunit Influenza Vaccine, When Administered to Adults Affected by Chronic Diseases Completed NCT00519064 Phase 3
22 A Study to Evaluate the Safety and Immunogenicity of 4 Doses of MenACWY Conjugate Vaccine, Administered Concomitantly With Routine Vaccines, Among Infants Aged 2 Months Completed NCT01000311 Phase 3
23 Study to Evaluate the Safety of Novartis MenACWY Conjugate Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants Completed NCT00806195 Phase 3
24 A Study to Evaluate Safety, Immunogenicity, and Lot-to-Lot Consistency of H5N1 Subunit Influenza Virus Vaccine in Healthy Adult Subjects ≥18 Years of Age Active, not recruiting NCT02839330 Phase 3
25 A Safety and Immunogenicity Study of IVACFLU-A/H5N1 Not yet recruiting NCT02612909 Phase 2, Phase 3
26 Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One Withdrawn NCT01546935 Phase 2, Phase 3
27 Inactivated Influenza A/H5N1 Vaccine in Adult Subjects at Risk of Occupational Exposure to Live H5N1 Viruses Unknown status NCT00417560 Phase 1, Phase 2
28 Immunogenicity and Safety of Pandemic Influenza Vaccine in Healthy Adults Unknown status NCT01640691 Phase 1, Phase 2
29 Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Unknown status NCT02095444 Phase 1, Phase 2
30 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Healthy Adults Completed NCT01776541 Phase 2
31 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines Completed NCT00478816 Phase 2
32 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Elderly Subjects Completed NCT01766921 Phase 2
33 Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine Completed NCT00561184 Phase 2
34 H7N9 Mix and Match With MF59 in Healthy Elderly Persons Completed NCT02213354 Phase 2
35 Systems Biology of Influenza A (H5N1) Virus Monovalent Vaccine With and Without Adjuvant System 03 (AS03) Completed NCT01910519 Phase 2
36 Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years Completed NCT00537524 Phase 2
37 Safety and Immunogenicity of Two Doses, Administered Three Weeks Apart, of Two Monovalent H5N1 Influenza Vaccines Containing 2 Doses of H5N1 Influenza Antigen, in Non-elderly Adult and Elderly Subjects Completed NCT00914771 Phase 2
38 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Children Completed NCT01776554 Phase 2
39 H5N1 (Clade 2) Vaccination of Adults and Elderly Completed NCT00680069 Phase 1, Phase 2
40 H7N9 Boost in Healthy Adults Completed NCT02586792 Phase 2
41 Immunogenicity and Safety Study of a Booster Vaccination With a Recombinant H5N1 Influenza HA Vaccine in Primed Adults Completed NCT01195038 Phase 2
42 Inactivated Influenza A/H5N1 Vaccine in the Elderly Completed NCT00230750 Phase 1, Phase 2
43 Safety, Reactogenicity and Immunogenicity of an H5N1 VLP Completed NCT00519389 Phase 1, Phase 2
44 A/H5N1 Vaccine in Healthy Children Aged 2-9 Years Completed NCT00133536 Phase 1, Phase 2
45 H7N9 Mix and Match With MF59 in Healthy Adults Completed NCT01938742 Phase 2
46 A Trial to Test the Response to Different Vaccination Regimens With an H5N1 Vaccine With AS03 in Adults Aged 18-64 Completed NCT00695669 Phase 2
47 H7N9 Mix and Match With AS03 and MF59 in Healthy Adults Completed NCT01942265 Phase 2
48 Safety and Immunogenicity of Two Adjuvanted and One Non-adjuvanted H5N1 Influenza Vaccine in Adults Completed NCT00382187 Phase 2
49 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Monovalent Pandemic H5N1 Vaccine in Adults Completed NCT01416571 Phase 2
50 Immunogenicity, Safety and Optimal Dose Finding Study of Recombinant Influenza H5N1 Vaccine in Healthy Young Adults Completed NCT00980447 Phase 2

Search NIH Clinical Center for Avian Influenza

Cochrane evidence based reviews: influenza in birds

Genetic Tests for Avian Influenza

Anatomical Context for Avian Influenza

MalaCards organs/tissues related to Avian Influenza:

39
Eye, Testes, T Cells, Lung, Myeloid, B Cells, Trachea

The Foundational Model of Anatomy Ontology organs/tissues related to Avian Influenza:

18
Respiratory Tract Of Humans

Publications for Avian Influenza

Articles related to Avian Influenza:

(show top 50) (show all 713)
id Title Authors Year
1
Quantifying predictors for the spatial diffusion of avian influenza virus in China. ( 28086751 )
2017
2
OIE avian influenza portal. ( 28062760 )
2017
3
Experimental infection of mandarin duck with highly pathogenic avian influenza A (H5N8 and H5N1) viruses. ( 28062008 )
2017
4
Estimating Risks of Inapparent Avian Exposure for Human Infection: Avian Influenza Virus A (H7N9) in Zhejiang Province, China. ( 28054599 )
2017
5
Novel real-time PCR-based patho- and phylotyping of potentially zoonotic avian influenza A subtype H5 viruses at risk of incursion into Europe in 2017. ( 28084214 )
2017
6
Novel variants of clade 2.3.2.1 H5N1 highly pathogenic avian influenza virus in migratory waterfowl of Hongze Lake. ( 28062014 )
2017
7
Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. ( 28061848 )
2017
8
Single PA mutation as a high yield determinant of avian influenza vaccines. ( 28084423 )
2017
9
Proteome Response of Chicken Embryo Fibroblast Cells to Recombinant H5N1 Avian Influenza Viruses with Different Neuraminidase Stalk Lengths. ( 28079188 )
2017
10
Genetic characterisation of novel, highly pathogenic avian influenza (HPAI) H5N6 viruses isolated in birds, South Korea, November 2016. ( 28079520 )
2017
11
New real time and conventional RT-PCRs for updated molecular diagnosis of infectious bronchitis virus infection (IBV) in chickens in Egypt associated with frequent co-infections with avian influenza and Newcastle Disease viruses. ( 28336367 )
2017
12
Vaccine efficacy of an inactivated, chimeric HA H9/H5N2 avian influenza virus and its suitability for the marker vaccine strategy. ( 28077631 )
2017
13
H9N2 avian influenza virus enhances the immune responses of BMDCs by down-regulating miR29c. ( 28063705 )
2017
14
Effects of HA and NA glycosylation pattern changes on the transmission of avian influenza A(H7N9) virus in guinea pigs. ( 27613087 )
2016
15
Identification of Epitopes for Neutralizing Antibodies Against H10N8 Avian Influenza Virus Hemagglutinin. ( 27594152 )
2016
16
Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. ( 27122581 )
2016
17
Ecosystem Interactions Underlie the Spread of Avian Influenza A Viruses with Pandemic Potential. ( 27166585 )
2016
18
Characteristics of two highly pathogenic avian influenza H5N8 viruses with different pathogenicity in mice. ( 27589977 )
2016
19
Isolation of H5N6, H7N9 and H9N2 avian influenza A viruses from air sampled at live poultry markets in China, 2014 and 2015. ( 27608369 )
2016
20
Pre-immune state induced by chicken interferon gamma inhibits the replication of H1N1 human and H9N2 avian influenza viruses in chicken embryo fibroblasts. ( 27121613 )
2016
21
Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses. ( 28004772 )
2016
22
Avian Influenza Virus H5 Strain with North American and Eurasian Lineage Genes in an Antarctic Penguin. ( 27662612 )
2016
23
The Dynamics of Avian Influenza: Individual-Based Model with Intervention Strategies in Traditional Trade Networks in Phitsanulok Province, Thailand. ( 27110273 )
2016
24
Predicting Avian Influenza Co-Infection with H5N1 and H9N2 in Northern Egypt. ( 27608035 )
2016
25
Highly Pathogenic Avian Influenza A(H5N1) Virus among Poultry, Ghana, 2015. ( 27584829 )
2016
26
Isolation and molecular characterization of reassortant H11N3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China. ( 27142079 )
2016
27
Characterization and Sequencing of an H6N6 Avian Influenza Virus Isolated from Sansui Sheldrake Ducks in Guizhou, Southwestern China. ( 27174267 )
2016
28
An evaluation of biosecurity compliance levels and assessment of associated risk factors for Highly Pathogenic Avian Influenza H5N1 infection of Live-Bird-Markets, Nigeria and Egypt. ( 27603430 )
2016
29
Surveillance, epidemiological, and virological detection of highly pathogenic H5N1 avian influenza viruses in duck and poultry from Bangladesh. ( 27599930 )
2016
30
Continuing Reassortant of H5N6 Subtype Highly Pathogenic Avian Influenza Virus in Guangdong. ( 27148209 )
2016
31
Novel Avian Influenza A(H5N8) Viruses in Migratory Birds, China, 2013-2014. ( 27192098 )
2016
32
Application of Species Distribution Modeling for Avian Influenza surveillance in the United States considering the North America Migratory Flyways. ( 27624404 )
2016
33
Call for vigilance as H5N8 avian influenza confirmed in Lincolnshire. ( 28008104 )
2016
34
Genetic diversity and pathogenic potential of low pathogenic H7 avian influenza viruses isolated from wild migratory birds in Korea. ( 27615552 )
2016
35
Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice. ( 27663652 )
2016
36
The avian influenza H9N2 at avian-human interface: A possible risk for the future pandemics. ( 28083072 )
2016
37
Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus. ( 27597953 )
2016
38
Protective efficacy of a prime-boost protocol using H5-DNA plasmid as prime and inactivated H5N2 vaccine as the booster against the Egyptian avian influenza challenge virus. ( 27640441 )
2016
39
Recombinant Newcastle disease virus expressing H9 HA protects chickens against heterologous avian influenza H9N2 virus challenge. ( 27102817 )
2016
40
Avian influenza virus in pregnancy. ( 27187752 )
2016
41
Susceptibility of primary chicken intestinal epithelial cells for low pathogenic avian influenza virus and velogenic viscerotropic Newcastle disease virus. ( 27596739 )
2016
42
Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation. ( 28012921 )
2016
43
Pathogenicity, Transmission and Antigenic Variation of H5N1 Highly Pathogenic Avian Influenza Viruses. ( 27199961 )
2016
44
Vaccination against H5 avian influenza virus induces long-term humoral immune responses in flamingoes (Phoenicopterus spp.). ( 27151883 )
2016
45
Genetic characterization and phylogenic analysis of H5N1 avian influenza virus detected in peafowl in Kirkuk province, Iraq. ( 28036106 )
2016
46
High antiviral effects of hibiscus tea extract on the H5 subtypes of low and highly pathogenic avian influenza viruses. ( 27193820 )
2016
47
Lack of chicken adaptation of newly emergent Eurasian H5N8 and reassortant H5N2 high pathogenicity avian influenza viruses in the U.S. is consistent with restricted poultry outbreaks in the Pacific flyway during 2014-2015. ( 27110710 )
2016
48
Isolation and phylogenetic characterization of haemagglutinin and neuraminidase genes of H9N2 low pathogenicity avian influenza virus isolated from commercial layers in India. ( 28004018 )
2016
49
Surveillance of Avian Influenza Virus in Aquatic Birds on the Brazilian Amazon Coast. ( 27645753 )
2016
50
Interventions in live poultry markets for the control of avian influenza: a systematic review. ( 27213177 )
2016

Variations for Avian Influenza

Expression for Avian Influenza

Search GEO for disease gene expression data for Avian Influenza.

Pathways for Avian Influenza

Pathways related to Avian Influenza according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.11 CRK CXCL10 DDX58 IFNA1 IRF7 STAT2
2
Show member pathways
12.64 CXCL10 DDX58 IFNA1 IRF7 SFTPD STAT2
3
Show member pathways
12.47 CXCL10 DDX58 IFNA1 IRF7 TNF
4
Show member pathways
12.27 DDX58 IFNA1 IRF7 STAT2
5 12.23 CXCL10 DDX58 IFNA1 IRF7 STAT2 TNF
6
Show member pathways
11.92 CXCL10 DDX58 FURIN IFNA1 IRF7 STAT2
7
Show member pathways
11.91 IFNA1 IRF7 STAT2 TNF
8 11.67 DDX58 IFNA1 IRF7 STAT2 TNF
9
Show member pathways
10.91 DDX58 IRF7 STAT2
10
Show member pathways
9.83 FURIN PCSK5 PCSK6

GO Terms for Avian Influenza

Cellular components related to Avian Influenza according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL10 FURIN IFNA1 PCSK5 PCSK6 SFTPD
2 Golgi lumen GO:0005796 9.33 FURIN PCSK5 PCSK6
3 extracellular region GO:0005576 9.28 CXCL10 FURIN IFNA1 NEU1 PCSK5 PCSK6

Biological processes related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 FURIN PCSK5 PCSK6 TMPRSS11A TMPRSS13
2 defense response GO:0006952 9.75 CXCL10 IFNA1 TNF
3 response to virus GO:0009615 9.67 CXCL10 DDX58 IRF7 TNF
4 protein processing GO:0016485 9.65 FURIN PCSK5 PCSK6
5 type I interferon signaling pathway GO:0060337 9.63 IFNA1 IRF7 STAT2
6 lipoprotein metabolic process GO:0042157 9.61 FURIN PCSK5 PCSK6
7 negative regulation of mitotic cell cycle GO:0045930 9.6 SCRIB TNF
8 positive regulation of interferon-beta production GO:0032728 9.59 DDX58 IRF7
9 positive regulation of interleukin-8 production GO:0032757 9.58 DDX58 TNF
10 negative regulation of myoblast differentiation GO:0045662 9.56 CXCL10 TNF
11 signal peptide processing GO:0006465 9.55 FURIN PCSK5
12 defense response to virus GO:0051607 9.55 CXCL10 DDX58 IFNA1 IRF7 STAT2
13 embryonic digestive tract development GO:0048566 9.54 PCSK5 TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 FURIN TNF
15 positive regulation of interferon-alpha production GO:0032727 9.51 DDX58 IRF7
16 secretion by cell GO:0032940 9.49 FURIN PCSK6
17 peptide hormone processing GO:0016486 9.43 FURIN PCSK5 PCSK6
18 peptide biosynthetic process GO:0043043 9.4 FURIN PCSK5
19 nerve growth factor production GO:0032902 9.32 FURIN PCSK6
20 regulation of lipoprotein lipase activity GO:0051004 9.13 FURIN PCSK5 PCSK6
21 nerve growth factor processing GO:0032455 8.8 FURIN PCSK5 PCSK6

Molecular functions related to Avian Influenza according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.91 DDX58 FURIN NEU1 PCSK5 PCSK6 TMPRSS11A
2 peptidase activity GO:0008233 9.72 FURIN PCSK5 PCSK6 TMPRSS11A TMPRSS13
3 endopeptidase activity GO:0004175 9.43 FURIN PCSK5 PCSK6
4 serine-type endopeptidase activity GO:0004252 9.35 FURIN PCSK5 PCSK6 TMPRSS11A TMPRSS13
5 nerve growth factor binding GO:0048406 9.16 FURIN PCSK6
6 serine-type peptidase activity GO:0008236 9.02 FURIN PCSK5 PCSK6 TMPRSS11A TMPRSS13

Sources for Avian Influenza

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