MCID: AVN001
MIFTS: 51

Avian Influenza malady

Infectious diseases, Respiratory diseases categories
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Summaries for Avian Influenza

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Birds, just like people, get the flu. bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. most bird flu viruses can only infect other birds. however, bird flu can pose health risks to people. the first case of a bird flu virus infecting a person directly, h5n1, was in hong kong in 1997. since then, the bird flu virus has spread to birds in countries in asia, africa, the middle east, and europe. human infection is still very rare, but the virus that causes the infection in birds might change, or mutate, to more easily infect humans. this could lead to a pandemic, a worldwide outbreak of the illness. during an outbreak of bird flu, people who have contact with infected birds can become sick. it may also be possible to catch bird flu by eating poultry or eggs that are not well cooked or through contact with a person who has it. bird flu can make people very sick or even cause death. antiviral medicines may make the illness less severe, and may help prevent the flu in people who were exposed to it. there is currently no vaccine.

MalaCards: Avian Influenza, also known as bird flu, is related to influenza and pneumonia, and has symptoms including acute respiratory distress, pneumonia and neurologic changes. An important gene associated with Avian Influenza is NEU1 (sialidase 1 (lysosomal sialidase)). The compounds monosaccharide and n-acetylglucosamine have been mentioned in the context of this disorder. Affiliated tissues include respiratory tract of humans, testes and t cells, and related mouse phenotypes are liver/biliary system and respiratory system.

Disease Ontology:8 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in influenza a virus, which is transmitted by contact with infected poultry. five strains of avian influenza a viruses (h5n1, h7n3, h7n2, h7n7 and h9n2) are known to cause human infections. the infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

Wikipedia:65 Avian influenza ? known informally as avian flu or bird flu ? refers to \"influenza caused by viruses... more...

Aliases & Classifications for Avian Influenza

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8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

avian influenza 8 10
bird flu 8 34
influenza in birds 62
avian flu 8


External Ids:

Disease Ontology8 DOID:4492
SNOMED-CT58 55604004
MeSH35 D005585

Related Diseases for Avian Influenza

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to avian influenza

Symptoms for Avian Influenza

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • acute respiratory distress
  • pneumonia
  • neurologic changes
  • vomiting
  • diarrhea
  • nausea
  • muscle aches
  • sore throat
  • cough
  • fever

Drugs & Therapeutics for Avian Influenza

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Avian Influenza

Search NIH Clinical Center for Avian Influenza

Genetic Tests for Avian Influenza

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Anatomical Context for Avian Influenza

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Avian Influenza:

33
Testes, T cells, Lung, Trachea, B cells, Nk cells, Myeloid, Brain

FMA organs/tissues related to Avian Influenza:

14
Respiratory tract of humans

Animal Models for Avian Influenza or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Avian Influenza:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7CCR1, NEU1, FURIN
2MP:00053888.5CCR1, NEU1, SCRIB, SFTPD
3MP:00053978.0FURIN, SFTPD, NEU1, CCR1
4MP:00053877.8CCR1, NEU1, SFTPD, FURIN
5MP:00107687.6FURIN, SFTPD, SCRIB, NEU1, CCR1

Publications for Avian Influenza

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52PubMed
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Articles related to Avian Influenza:

(show top 50)    (show all 570)
idTitleAuthorsYear
1
Avian influenza H9N2 seroprevalence among swine farm residents in China. (24390939)
2014
2
Effects of different polymerases of avian influenza viruses on the growth and pathogenicity of A/Puerto Rico/8/1934 (H1N1)-derived reassorted viruses. (24296300)
2014
3
Exposure to avian influenza H7N9 in farms and wet markets. (23664058)
2013
4
Pathogenicity of an H5N1 highly pathogenic avian influenza virus isolated in the 2010-2011 winter in Japan to mandarin ducks. (23318574)
2013
5
Seroprevalence of antibodies to highly pathogenic avian influenza A (H5N1) virus among close contacts exposed to H5N1 cases, China, 2005-2008. (23967241)
2013
6
Characterisation and haemagglutinin gene epitope mapping of a variant strain of H5N1 subtype avian influenza virus. (23265247)
2013
7
Immune responses of chickens inoculated with recombinant Lactobacillus expressing the haemagglutinin of the avian influenza virus. (23937220)
2013
8
Surveillance for avian influenza A(H7N9), Beijing, China, 2013. (24274700)
2013
9
Differences in the detection of highly pathogenic avian influenza H5N1 virus in feather samples from 4-week-old and 24-week-old infected Pekin ducks (Anas platyrhynchos var. domestica). (23608476)
2013
10
Development and optimization of a biopreparedness protocol for extracting and detecting avian influenza virus in broiler chicken meat. (23971811)
2013
11
Estimation of the sensitivity of the surveillance system for avian influenza in the western region of Cuba. (23564591)
2013
12
Avirulent Marek's disease virus type 1 strain 814 vectored vaccine expressing avian influenza (AI) virus H5 haemagglutinin induced better protection than turkey herpesvirus vectored AI vaccine. (23301062)
2013
13
Amaryllidaceae alkaloids inhibit nuclear-to-cytoplasmic export of ribonucleoprotein (RNP) complex of highly pathogenic avian influenza virus H5N1. (23136954)
2013
14
H7N3 live attenuated influenza vaccine has a potential to protect against new H7N9 avian influenza virus. (23988294)
2013
15
Discover binding pathways using the sliding binding-box docking approach: application to binding pathways of oseltamivir to avian influenza H5N1 neuraminidase. (23979194)
2013
16
Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China. (23614499)
2013
17
Age-specific and sex-specific morbidity and mortality from avian influenza A(H7N9). (24091087)
2013
18
Highly pathogenic avian influenza A(H5N1) mutants transmissible by air are susceptible to human and animal neutralizing antibodies. (23868877)
2013
19
Experimental infection of non-human primates with avian influenza virus (H9N2). (23665767)
2013
20
Full Genome Sequence of an Avian Influenza H5N1 Virus Isolated from the Environment in Hunan Province, China. (23682135)
2013
21
Goose Toll-like receptor 7 (TLR7), myeloid differentiation factor 88 (MyD88) and antiviral molecules involved in anti-H5N1 highly pathogenic avian influenza virus response. (23481654)
2013
22
Avian influenza: mixed infections and missing viruses. (23921843)
2013
23
Baculovirus vector as an avian influenza vaccine: hemagglutinin expression and presentation augment the vaccine immunogenicity. (23313887)
2013
24
Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. (23526211)
2013
25
Evaluation of phenotypic markers in full genome sequences of avian influenza isolates from California. (23891310)
2013
26
Qualitative dynamics of lowly- and highly-pathogenic avian influenza strains. (23485554)
2013
27
Descriptive Results of a Prospective Cohort Study of Avian Influenza in the Mekong River Delta of Viet Nam. (23331425)
2013
28
Contribution of the NS1 Gene of H7 Avian Influenza Virus Strains to Pathogenicity in Chickens. (24236854)
2013
29
Avian Influenza A(H7N9) Virus Screening in Patients with Fever and Flu-Like Symptoms in a Tertiary Hospital in an Area with Confirmed Cases. (24367529)
2013
30
Subtype diversity and reassortment potential for co-circulating avian influenza viruses at a diversity hot spot. (24164627)
2013
31
Is avian influenza A (H7N9) virus staggering its way to humans? (23742902)
2013
32
The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks. (23290928)
2013
33
Virucidal effect of acidic electrolyzed water and neutral electrolyzed water on avian influenza viruses. (24026292)
2013
34
An experimental model to analyse the risk of introduction of a duck-originated H5 low-pathogenic avian influenza virus in poultry through close contact and contaminative transmission. (24252718)
2013
35
Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-I^ T cell responses in humans. (23357198)
2013
36
Receptor binding by a ferret-transmissible H5 avian influenza virus. (23615615)
2013
37
Risk factors for avian influenza and Newcastle disease in smallholder farming systems, Madagascar highlands. (22130311)
2012
38
The pathogenesis of low pathogenic avian influenza in mallards. (23402122)
2012
39
Satellite tracking on the flyways of brown-headed gulls and their potential role in the spread of highly pathogenic avian influenza H5N1 virus. (23209623)
2012
40
Transmissibility of the highly pathogenic avian influenza virus, subtype H5N1 in domestic poultry: a spatio-temporal estimation at the global scale. (23242687)
2012
41
Complete genome sequence of an H10N5 avian influenza virus isolated from pigs in central China. (23166264)
2012
42
Associations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers. (23155008)
2012
43
Surveillance for avian influenza and Newcastle disease in backyard poultry flocks in CA'te d'Ivoire, 2007-2009. (23520736)
2012
44
A randomized clinical trial of an inactivated avian influenza A (H7N7) vaccine. (23239968)
2012
45
Avian influenza virus and Newcastle disease virus (NDV) surveillance in commercial breeding farm in China and the characterization of Class I NDV isolates. (20133090)
2010
46
Heterosubtypic T-cell responses against avian influenza H5 haemagglutinin are frequently detected in individuals vaccinated against or previously infected with human subtypes of influenza. (19453462)
2008
47
Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. (18199656)
2008
48
Human parainfluenza viruses hPIV1 and hPIV3 bind oligosaccharides with alpha2-3-linked sialic acids that are distinct from those bound by H5 avian influenza virus hemagglutinin. (17522226)
2007
49
Insufficient perforin expression in CD8+ T cells in response to hemagglutinin from avian influenza (H5N1) virus. (16585542)
2006
50
p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. (16051807)
2005

Variations for Avian Influenza

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Expression for genes affiliated with Avian Influenza

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Avian Influenza

Search GEO for disease gene expression data for Avian Influenza.

Pathways for genes affiliated with Avian Influenza

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Compounds for genes affiliated with Avian Influenza

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank
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Compounds related to Avian Influenza according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1monosaccharide459.7NEU1, SFTPD
2n-acetylglucosamine459.6NEU1, SFTPD
3dmso459.5CCR1, NEU1
4agarose459.4SFTPD, NEU1
5con a459.4NEU1, FURIN
6carbohydrates459.3SFTPD, NEU1
7mannose 6-phosphate45 2410.3NEU1, FURIN
8mannose459.1NEU1, SFTPD
9heparin45 29 24 1111.9FURIN, NEU1, CCR1
10cysteine458.3FURIN, SFTPD, NEU1, CCR1
11serine457.9CCR1, NEU1, TMPRSS11A, SFTPD, FURIN

GO Terms for genes affiliated with Avian Influenza

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16Gene Ontology
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Cellular components related to Avian Influenza according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057649.4NEU1, SFTPD

Molecular functions related to Avian Influenza according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.2TMPRSS11A, FURIN

Products for genes affiliated with Avian Influenza

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Avian Influenza

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet