MCID: AVD001
MIFTS: 40

Avoidant Personality Disorder malady

Categories: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 12 14 69
Anxious Personality Disorder 12 69
Personality Disorders 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1509
ICD10 33 F60.6
ICD9CM 35 301.82
MeSH 42 D010554
NCIt 47 C92636
SNOMED-CT 64 191771004 37746008
UMLS 69 C0004444

Summaries for Avoidant Personality Disorder

Disease Ontology : 12 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary : Avoidant Personality Disorder, also known as anxious personality disorder, is related to personality disorder and social phobia, and has symptoms including fatigue, sleep disturbances and photophobia. An important gene associated with Avoidant Personality Disorder is AMY1A (Amylase, Alpha 1A (Salivary)), and among its related pathways/superpathways are PAK Pathway and CCR5 Pathway in Macrophages. The drugs Nicotine and Silicon have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and amygdala, and related phenotypes are liver/biliary system and nervous system

Wikipedia : 71 Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a... more...

Related Diseases for Avoidant Personality Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to Avoidant Personality Disorder

Symptoms & Phenotypes for Avoidant Personality Disorder

UMLS symptoms related to Avoidant Personality Disorder:


fatigue, sleep disturbances, photophobia, personality changes, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Avoidant Personality Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 FLNA MME WASF1 WASF2 CCR5 CRH
2 nervous system MP:0003631 9.36 CCR5 CRH CTSB CXCL12 CXCR4 FLNA

Drugs & Therapeutics for Avoidant Personality Disorder

Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotine Approved 54-11-5 942 89594
2
Silicon 7440-21-3 4082203

Interventional clinical trials:


id Name Status NCT ID Phase
1 Effectiveness of Group Based Schema Therapy in the Treatment of Personality Disorders Completed NCT00247234 Phase 2
2 Developing Genetic Education for Smoking Cessation Completed NCT01186016
3 Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions Recruiting NCT02465697
4 Personality Pathology and Cerebral Processing in Eating Disorders Recruiting NCT02980120

Search NIH Clinical Center for Avoidant Personality Disorder

Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

Anatomical Context for Avoidant Personality Disorder

MalaCards organs/tissues related to Avoidant Personality Disorder:

39
Testes, Brain, Amygdala

Publications for Avoidant Personality Disorder

Articles related to Avoidant Personality Disorder:

(show top 50) (show all 94)
id Title Authors Year
1
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. ( 27744447 )
2016
2
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. ( 27653504 )
2016
3
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. ( 26651009 )
2016
4
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. ( 27227557 )
2016
5
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. ( 27547506 )
2016
6
Group schema therapy versus group cognitive behavioral therapy for social anxiety disorder with comorbid avoidant personality disorder: study protocol for a randomized controlled trial. ( 27717405 )
2016
7
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. ( 27155069 )
2016
8
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. ( 27662043 )
2016
9
Avoidant Personality Disorder: a Current Review. ( 26830887 )
2016
10
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. ( 27505187 )
2016
11
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. ( 26569037 )
2015
12
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. ( 26481549 )
2015
13
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. ( 26129819 )
2015
14
Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25978045 )
2015
15
Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25815817 )
2015
16
Attachment styles in patients with avoidant personality disorder compared with social phobia. ( 26332087 )
2015
17
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. ( 25557644 )
2015
18
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
19
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. ( 25215596 )
2014
20
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. ( 24275960 )
2014
21
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. ( 25451388 )
2014
22
Personality functioning in patients with avoidant personality disorder and social phobia. ( 23786266 )
2013
23
A parallel process growth model of avoidant personality disorder symptoms and personality traits. ( 22506627 )
2013
24
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. ( 24343980 )
2013
25
Brief Cognitive Therapy for Avoidant Personality Disorder. ( 24377411 )
2013
26
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. ( 24378158 )
2013
27
Social Phobia and Avoidant Personality Disorder: Similar but Different? ( 23398095 )
2013
28
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? ( 22705954 )
2012
29
Psychotherapy of an older adult with an avoidant personality disorder. ( 20880430 )
2011
30
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. ( 21308885 )
2011
31
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. ( 22448805 )
2011
32
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. ( 20677852 )
2010
33
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? ( 19536877 )
2010
34
Relations among symptoms of social phobia subtypes, avoidant personality disorder, panic, and depression. ( 20171323 )
2010
35
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. ( 20053537 )
2010
36
Changes in defensive functioning in a case of avoidant personality disorder. ( 22402007 )
2010
37
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. ( 19516064 )
2009
38
A functionalist perspective on social anxiety and avoidant personality disorder. ( 19825257 )
2009
39
Avoidant personality disorder and its relationship to social phobia. ( 19187715 )
2009
40
Predictors of withdrawal: possible precursors of avoidant personality disorder. ( 19583885 )
2009
41
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. ( 19683617 )
2009
42
The relationship between generalized social phobia and avoidant personality disorder in a national mental health survey. ( 19031488 )
2009
43
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? ( 19728570 )
2009
44
The impact of avoidant personality disorder on psychosocial impairment is substantial. ( 19333817 )
2009
45
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. ( 17618526 )
2008
46
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? ( 17161000 )
2008
47
The relationship between avoidant personality disorder and social phobia: a population-based twin study. ( 17974938 )
2007
48
Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders The UCLA family study. ( 17306508 )
2007
49
Cognitive-behavioural therapy for avoidant personality disorder. ( 17197665 )
2007
50
Psychoanalysis with avoidant personality disorder: A systematic case study. ( 22122163 )
2007

Variations for Avoidant Personality Disorder

Expression for Avoidant Personality Disorder

Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for Avoidant Personality Disorder

GO Terms for Avoidant Personality Disorder

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 AMY1A AMY1B AMY1C CTSB CXCL12 CXCR4
2 extracellular space GO:0005615 9.7 AMY1A AMY1B AMY1C CCL5 CRH CTSB
3 extracellular region GO:0005576 9.32 AMY1A AMY1B AMY1C C6orf15 CCL5 CRH
4 SCAR complex GO:0031209 8.96 WASF1 WASF2

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 12)
id Name GO ID Score Top Affiliating Genes
1 response to virus GO:0009615 9.65 CCL5 CXCL12 CXCR4
2 digestion GO:0007586 9.58 AMY1A AMY1B AMY1C
3 Rac protein signal transduction GO:0016601 9.51 WASF1 WASF2
4 positive regulation of monocyte chemotaxis GO:0090026 9.49 CCL5 CXCL12
5 positive regulation of calcium ion import GO:0090280 9.46 CRH CXCL12
6 positive regulation of T cell migration GO:2000406 9.43 CCL5 CXCL12
7 fusion of virus membrane with host plasma membrane GO:0019064 9.37 CCR5 CXCR4
8 chemotaxis GO:0006935 9.35 CCL5 CCR5 CXCL12 CXCR4 CXCR5
9 dendritic cell chemotaxis GO:0002407 9.33 CCL5 CCR5 CXCR4
10 lamellipodium morphogenesis GO:0072673 9.32 WASF1 WASF2
11 entry into host cell GO:0030260 9.26 CCR5 CXCR4
12 chemokine-mediated signaling pathway GO:0070098 9.02 CCL5 CCR5 CXCL12 CXCR4 CXCR5

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.58 AMY1A AMY1B AMY1C
2 actin binding GO:0003779 9.55 CCR5 CXCR4 FLNA WASF1 WASF2
3 chemokine receptor activity GO:0004950 9.43 CCR5 CXCR4
4 chemokine receptor binding GO:0042379 9.37 CCL5 CXCL12
5 C-C chemokine binding GO:0019957 9.32 CCR5 CXCR4
6 C-X-C chemokine receptor activity GO:0016494 9.26 CXCR4 CXCR5
7 cation binding GO:0043169 9.13 AMY1A AMY1B AMY1C
8 alpha-amylase activity GO:0004556 8.8 AMY1A AMY1B AMY1C

Sources for Avoidant Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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