MCID: AVD001
MIFTS: 44

Avoidant Personality Disorder malady

Category: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

About this section

Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 10 12 65
Anxious Personality Disorder 10 65
 
Personality Disorders 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:1509
ICD1027 F60.6
ICD9CM29 301.82
SNOMED-CT59 191771004, 37746008
MeSH36 D010554
NCIt42 C92636
UMLS65 C0004444, C0494415, C0031212

Summaries for Avoidant Personality Disorder

About this section
Disease Ontology:10 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary: Avoidant Personality Disorder, also known as anxious personality disorder, is related to intermittent explosive disorder and obsessive-compulsive personality disorder, and has symptoms including pseudobulbar behavioral symptoms, restlessness and personality change. An important gene associated with Avoidant Personality Disorder is SPRN (Shadow Of Prion Protein Homolog (Zebrafish)), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Syndecan-4-mediated signaling events. Affiliated tissues include brain, bone and lung, and related mouse phenotypes are liver/biliary system and behavior/neurological.

Wikipedia:68 Avoidant personality disorder (AvPD), also known as anxious personality disorder, is a Cluster C... more...

Related Diseases for Avoidant Personality Disorder

About this section

Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1intermittent explosive disorder30.2HTR2A, MAOA
2obsessive-compulsive personality disorder28.8MAOA, MME, WASF1, WASF2
3personality disorder24.0APP, CCL5, CCR5, CRH, CTSB, CXCL12
4ring chromosome 14 syndrome10.7HTR2A, MAOA
5ehrlichiosis10.6HTR2A, MAOA
6steatorrhea10.6CTSB, HTR2A
7brachial plexus neoplasm10.6HTR2A, MAOA
8kleptomania10.5HTR2A, MAOA
9aids dysmorphic syndrome10.5CXCL12, CXCR4
10perrault syndrome10.5HTR2A, MAOA
11social phobia10.5
12vogt-koyanagi-harada disease10.5CRH, HTR2A, MAOA
13hairy cell leukemia10.5CRH, HTR2A, MAOA
14whim syndrome10.5CXCL12, CXCR4
15tympanosclerosis10.5CRH, HTR2A, MAOA
16chronic mucocutaneous candidiasis10.4CRH, HTR2A, MAOA
17malignant hyperthermia10.4CRH, HTR2A, MAOA
18mental depression10.4CRH, HTR2A, MAOA
19may-hegglin anomaly10.4CRH, HTR2A, MAOA
20encephalomalacia10.4CRH, HTR2A, MAOA
21hyperglobulinemic purpura10.4CRH, HTR2A, MAOA
22malignant pleural mesothelioma10.4CCL5, CCR5
23nodular episcleritis10.4CRH, HTR2A
24adrenal cortical adenoma10.3APP, HTR2A, MAOA
25birdshot chorioretinopathy10.3APP, CRH
26ischemic heart disease10.3CXCL12, CXCR5
27ovarian mixed germ cell neoplasm10.3HTR2A, MAOA
28atopic dermatitis10.2APP, CCR5, HTR2A
29urethral diverticulum10.2CCL5, CCR5, CXCR4
30small intestine cancer10.1CTSB, MME
31anxiety disorder10.1
32cytoplasmic body myopathy10.0CCR5, CXCL12
33colon sarcoma9.9CCL5, CCR5, CXCL12, CXCR4
34schizophrenia9.9
35bulimia nervosa9.9
36eating disorder9.9
37laryngeal adductor paralysis9.9CRH, HTR2A, MAOA, WASF1
38obsessive-compulsive disorder9.7
39schizotypal personality disorder9.7
40borderline personality disorder9.7
41substance abuse9.7
42parkinsonism-dystonia, infantile9.7HTR2A, MAOA, WASF1, WASF2
43smoking as a quantitative trait locus 19.6CXCL12, CXCR4, CXCR5, MME
44hypersensitivity syndrome, carbamazepine-induced9.5APP, CRH, CTSB, HTR2A, MME
45candidiasis9.1CRH, FMR1, HTR2A, MAOA, WASF1, WASF2

Comorbidity relations with Avoidant Personality Disorder via Phenotypic Disease Network (PDN):


Major Depressive Disorder and Accelerated Response to Antidepressant Drug TreatmentDependent Personality Disorder
Dysthymic Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to avoidant personality disorder

Symptoms for Avoidant Personality Disorder

About this section

UMLS symptoms related to Avoidant Personality Disorder:


pseudobulbar behavioral symptoms, restlessness, personality change, photophobia, sleep disturbances, fatigue, drooling

Drugs & Therapeutics for Avoidant Personality Disorder

About this section

Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotineapproved97354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(R,S)-nicotine
(RS)-nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(┬▒)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
American Fare Nicotine Transdermal System
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Careone Nicotine Transdermal System Step 1
Careone Nicotine Transdermal System Step 2
Careone Nicotine Transdermal System Step 3
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Equaline Nicotine Transdermal System STEP 1
Exchange Select Nicotine Transdermal System STEP 3
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
Habitrol Patch Nicotine Transdermal System, Step 1
Habitrol Patch Nicotine Transdermal System, Step 2
Habitrol Patch Nicotine Transdermal System, Step 3
Healthmart Nicotine Transdermal System STEP 1
Healthmart Nicotine Transdermal System STEP 2
Healthmart Nicotine Transdermal System STEP 3
Kroger Nicotine Transdermal System STEP 1
Kroger Nicotine Transdermal System STEP 2
Kroger Nicotine Transdermal System STEP 3
L(-)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
L-Nicotine
LS-202
Leader Nicotine
Leader Nicotine Transdermal System STEP 1
Leader Nicotine Transdermal System STEP 2
Leader Nicotine Transdermal System STEP 3
MLS001055457
 
MLS001335905
Mach-Nic
Meijer Nicotine Transdermal System STEP 2
Meijer Nicotine Transdermal System Step 1
Meijer Nicotine Transdermal System Step 3
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm CQ
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine TRANSDERMAL SYSTEM
Nicotine Transdermal System PATCH KIT
Nicotine Transdermal System STEP 1
Nicotine Transdermal System STEP 2
Nicotine Transdermal System STEP 3
Nicotine Transdermal System Step 1
Nicotine Transdermal System Step 2
Nicotine Transdermal System Step 3
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotine transdermal system
Nicotrol
Nicotrol (professional Sample)
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
Rite Aid Nicotine Transdermal System Step 1
Rite Aid Nicotine Transdermal System Step 2
Rite Aid Nicotine Transdermal System Step 3
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Safeway Nicotine Transdermal System STEP 1
Safeway Nicotine Transdermal System STEP 2
Safeway Nicotine Transdermal System STEP 3
Smart Sense Nicotine
Sunmark Nicotine
Sunmark Nicotine Transdermal System STEP 1
Sunmark Nicotine Transdermal System STEP 2
Sunmark Nicotine Transdermal System STEP 3
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Group Based Schema Therapy in the Treatment of Personality DisordersCompletedNCT00247234Phase 2
2Developing Genetic Education for Smoking CessationCompletedNCT01186016
3Changes in the Brain as Borderline Patients Learn to Regulate Their EmotionsRecruitingNCT02465697

Search NIH Clinical Center for Avoidant Personality Disorder


Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

About this section

Anatomical Context for Avoidant Personality Disorder

About this section

MalaCards organs/tissues related to Avoidant Personality Disorder:

33
Brain, Bone, Lung, Heart, Endothelial, Breast, B cells

Animal Models for Avoidant Personality Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Avoidant Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2CCR5, CRH, CXCL12, MME, WASF1, WASF2
2MP:00053867.7APP, CCR5, CRH, CTSB, FMR1, HTR2A
3MP:00053697.4APP, CCR5, CXCL12, CXCR4, HTR2A, WASF1
4MP:00036316.7APP, CCR5, CRH, CTSB, CXCL12, CXCR4
5MP:00053876.4APP, CCL5, CCR5, CRH, CTSB, CXCL12

Publications for Avoidant Personality Disorder

About this section

Articles related to Avoidant Personality Disorder:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
Avoidant Personality Disorder: a Current Review. (26830887)
2016
2
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. (26651009)
2016
3
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. (26569037)
2015
4
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. (26129819)
2015
5
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. (26481549)
2015
6
Attachment styles in patients with avoidant personality disorder compared with social phobia. (26332087)
2015
7
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
8
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. (25215596)
2014
9
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. (24275960)
2014
10
Brief Cognitive Therapy for Avoidant Personality Disorder. (24377411)
2013
11
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
12
Personality functioning in patients with avoidant personality disorder and social phobia. (23786266)
2013
13
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. (24343980)
2013
14
Social Phobia and Avoidant Personality Disorder: Similar but Different? (23398095)
2013
15
A parallel process growth model of avoidant personality disorder symptoms and personality traits. (22506627)
2013
16
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
17
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. (22448805)
2011
18
Changes in defensive functioning in a case of avoidant personality disorder. (22402007)
2010
19
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? (19536877)
2010
20
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. (20677852)
2010
21
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
22
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
23
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. (19516064)
2009
24
Avoidant personality disorder and its relationship to social phobia. (19187715)
2009
25
The impact of avoidant personality disorder on psychosocial impairment is substantial. (19333817)
2009
26
Predictors of withdrawal: possible precursors of avoidant personality disorder. (19583885)
2009
27
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. (17618526)
2008
28
The relationship between avoidant personality disorder and social phobia: a population-based twin study. (17974938)
2007
29
Psychoanalysis with avoidant personality disorder: A systematic case study. (22122163)
2007
30
Integrated wilderness therapy for avoidant personality disorder. (16923635)
2006
31
A comparison of publication trends on avoidant personality disorder and social phobia. (16962667)
2006
32
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
33
Factorial structure and diagnostic efficiency of DSM-IV criteria for avoidant personality disorder in patients with binge eating disorder. (15350855)
2004
34
Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function. (14971632)
2004
35
Childhood antecedents of avoidant personality disorder: a retrospective study. (12960713)
2003
36
Personality and mood correlates of avoidant personality disorder. (12004493)
2002
37
The influence on treatment gain of comorbid avoidant personality disorder in patients with social phobia. (11838470)
2002
38
Generalized social phobia versus avoidant personality disorder: differences in psychopathology, personality traits, and social and occupational functioning. (11043888)
2000
39
The relationship of social phobia to avoidant personality disorder: a proposal to reclassify avoidant personality disorder based on clinical empirical findings. (10960264)
2000
40
Multimodal comparisons of social phobia subtypes and avoidant personality disorder. (10372342)
1999
41
Avoidant personality disorder and taijin kyoufu: sociocultural implications of the WHO/ADAMHA International Study of Personality Disorders in Japan. (8739661)
1996
42
The treatment of avoidant personality disorder by social skills training in the clinic or in real-life settings. (7834593)
1994
43
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992
44
Social phobia: a comparison of specific and generalized subtypes and avoidant personality disorder. (1583227)
1992
45
Generalized social phobia versus avoidant personality disorder: a commentary on three studies. (1583229)
1992
46
The relationship of social phobia subtypes and avoidant personality disorder. (1778076)
1991
47
A test of the therapeutic mechanism in social skills training with avoidant personality disorder. (2592963)
1989
48
Perception of early parenting by patients diagnosed avoidant personality disorder: a test of the overprotection hypothesis. (2596337)
1989
49
Psychopharmacological treatment of avoidant personality disorder. (2684499)
1989
50
Clinical phobias and avoidant personality disorder among alcoholics admitted to an alcoholism rehabilitation setting. (3791123)
1986

Variations for Avoidant Personality Disorder

About this section

Expression for genes affiliated with Avoidant Personality Disorder

About this section
Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for genes affiliated with Avoidant Personality Disorder

About this section

GO Terms for genes affiliated with Avoidant Personality Disorder

About this section

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:000590110.0CTSB, HTR2A

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:007072310.3CCL5, CCR5
2positive regulation of monocyte chemotaxisGO:009002610.2CCL5, CXCL12
3positive regulation of T cell migrationGO:200040610.1CCL5, CXCL12
4dendritic cell chemotaxisGO:000240710.0CCL5, CXCR4
5negative regulation of cell deathGO:00605489.6CCL5, CRH, CTSB
6Rac protein signal transductionGO:00166019.4WASF1, WASF2
7chemokine-mediated signaling pathwayGO:00700989.2CCL5, CCR5, CXCL12
8G-protein coupled receptor signaling pathwayGO:00071868.7CCL5, CXCL12, CXCR4, CXCR5, HTR2A

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037799.0CCR5, WASF1, WASF2

Sources for Avoidant Personality Disorder

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet