MCID: AVD001
MIFTS: 40

Avoidant Personality Disorder malady

Category: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

About this section

Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 11 13 68
Anxious Personality Disorder 11 68
 
Personality Disorders 39 68

Classifications:



External Ids:

Disease Ontology11 DOID:1509
ICD1030 F60.6
ICD9CM32 301.82
SNOMED-CT62 191771004, 37746008
MeSH39 D010554
NCIt45 C92636

Summaries for Avoidant Personality Disorder

About this section
Disease Ontology:11 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary: Avoidant Personality Disorder, also known as anxious personality disorder, is related to personality disorder and social phobia, and has symptoms including fatigue, sleep disturbances and photophobia. An important gene associated with Avoidant Personality Disorder is AMY1A (Amylase, Alpha 1A (Salivary)), and among its related pathways are Syndecan-4-mediated signaling events and Carbohydrate digestion and absorption. Affiliated tissues include testes, amygdala and brain, and related mouse phenotypes are liver/biliary system and nervous system.

Wikipedia:71 Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a... more...

Related Diseases for Avoidant Personality Disorder

About this section

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to avoidant personality disorder

Symptoms & Phenotypes for Avoidant Personality Disorder

About this section

UMLS symptoms related to Avoidant Personality Disorder:


fatigue, sleep disturbances, photophobia, personality changes, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6CCR5, CRH, CXCL12, FLNA, MME, WASF1
2MP:00036316.8CCR5, CRH, CTSB, CXCL12, CXCR4, FLNA

Drugs & Therapeutics for Avoidant Personality Disorder

About this section

Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotineapproved110354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-(−)-nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(−)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-(N-methylpyrollidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L(−)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch
2
Silicon1037440-21-34082203
Synonyms:
Si
 
Silica
Silicate
Silicic acid

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Group Based Schema Therapy in the Treatment of Personality DisordersCompletedNCT00247234Phase 2
2Developing Genetic Education for Smoking CessationCompletedNCT01186016
3Changes in the Brain as Borderline Patients Learn to Regulate Their EmotionsRecruitingNCT02465697
4Personality Pathology and Cerebral Processing in Eating DisordersRecruitingNCT02980120

Search NIH Clinical Center for Avoidant Personality Disorder


Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

About this section

Anatomical Context for Avoidant Personality Disorder

About this section

MalaCards organs/tissues related to Avoidant Personality Disorder:

36
Testes, Amygdala, Brain

Publications for Avoidant Personality Disorder

About this section

Articles related to Avoidant Personality Disorder:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. (27744447)
2016
2
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. (27653504)
2016
3
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. (26651009)
2016
4
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. (27227557)
2016
5
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. (27547506)
2016
6
Group schema therapy versus group cognitive behavioral therapy for social anxiety disorder with comorbid avoidant personality disorder: study protocol for a randomized controlled trial. (27717405)
2016
7
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. (27155069)
2016
8
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. (27662043)
2016
9
Avoidant Personality Disorder: a Current Review. (26830887)
2016
10
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. (27505187)
2016
11
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. (26569037)
2015
12
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. (26481549)
2015
13
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. (26129819)
2015
14
Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. (25978045)
2015
15
Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. (25815817)
2015
16
Attachment styles in patients with avoidant personality disorder compared with social phobia. (26332087)
2015
17
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. (25557644)
2015
18
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
19
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. (25215596)
2014
20
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. (24275960)
2014
21
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. (25451388)
2014
22
Personality functioning in patients with avoidant personality disorder and social phobia. (23786266)
2013
23
A parallel process growth model of avoidant personality disorder symptoms and personality traits. (22506627)
2013
24
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. (24343980)
2013
25
Brief Cognitive Therapy for Avoidant Personality Disorder. (24377411)
2013
26
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
27
Social Phobia and Avoidant Personality Disorder: Similar but Different? (23398095)
2013
28
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
29
Psychotherapy of an older adult with an avoidant personality disorder. (20880430)
2011
30
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. (21308885)
2011
31
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. (22448805)
2011
32
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. (20677852)
2010
33
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? (19536877)
2010
34
Relations among symptoms of social phobia subtypes, avoidant personality disorder, panic, and depression. (20171323)
2010
35
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. (20053537)
2010
36
Changes in defensive functioning in a case of avoidant personality disorder. (22402007)
2010
37
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. (19516064)
2009
38
A functionalist perspective on social anxiety and avoidant personality disorder. (19825257)
2009
39
Avoidant personality disorder and its relationship to social phobia. (19187715)
2009
40
Predictors of withdrawal: possible precursors of avoidant personality disorder. (19583885)
2009
41
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
42
The relationship between generalized social phobia and avoidant personality disorder in a national mental health survey. (19031488)
2009
43
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
44
The impact of avoidant personality disorder on psychosocial impairment is substantial. (19333817)
2009
45
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. (17618526)
2008
46
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? (17161000)
2008
47
The relationship between avoidant personality disorder and social phobia: a population-based twin study. (17974938)
2007
48
Avoidant personality disorder is a separable schizophrenia-spectrum personality disorder even when controlling for the presence of paranoid and schizotypal personality disorders The UCLA family study. (17306508)
2007
49
Cognitive-behavioural therapy for avoidant personality disorder. (17197665)
2007
50
Psychoanalysis with avoidant personality disorder: A systematic case study. (22122163)
2007

Variations for Avoidant Personality Disorder

About this section

Expression for genes affiliated with Avoidant Personality Disorder

About this section
Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for genes affiliated with Avoidant Personality Disorder

About this section

GO Terms for genes affiliated with Avoidant Personality Disorder

About this section

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SCAR complexGO:00312099.2WASF1, WASF2
2extracellular spaceGO:00056158.4AMY1A, AMY1B, AMY1C, CCL5, CRH, CTSB
3extracellular regionGO:00055768.2AMY1A, AMY1B, AMY1C, C6orf15, CCL5, CRH
4extracellular exosomeGO:00700628.1AMY1A, AMY1B, AMY1C, CTSB, CXCL12, CXCR4

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of monocyte chemotaxisGO:009002610.5CCL5, CXCL12
2positive regulation of T cell migrationGO:200040610.5CCL5, CXCL12
3entry into host cellGO:003026010.5CCR5, CXCR4
4positive regulation of calcium ion importGO:009028010.5CRH, CXCL12
5fusion of virus membrane with host plasma membraneGO:001906410.5CCR5, CXCR4
6dendritic cell chemotaxisGO:000240710.3CCL5, CCR5, CXCR4
7digestionGO:00075869.9AMY1A, AMY1B, AMY1C
8lamellipodium morphogenesisGO:00726739.8WASF1, WASF2
9Rac protein signal transductionGO:00166019.8WASF1, WASF2
10response to virusGO:00096159.6CCL5, CXCL12, CXCR4
11chemokine-mediated signaling pathwayGO:00700989.4CCL5, CCR5, CXCL12, CXCR4, CXCR5
12chemotaxisGO:00069359.4CCL5, CCR5, CXCL12, CXCR4, CXCR5

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1chemokine receptor bindingGO:004237910.5CCL5, CXCL12
2C-C chemokine bindingGO:001995710.5CCR5, CXCR4
3chemokine receptor activityGO:000495010.4CCR5, CXCR4
4C-X-C chemokine receptor activityGO:001649410.1CXCR4, CXCR5
5alpha-amylase activityGO:00045569.9AMY1A, AMY1B, AMY1C
6cation bindingGO:00431699.8AMY1A, AMY1B, AMY1C
7hydrolase activity, acting on glycosyl bondsGO:00167989.3AMY1A, AMY1B, AMY1C
8actin bindingGO:00037799.0CCR5, CXCR4, FLNA, WASF1, WASF2

Sources for Avoidant Personality Disorder

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet