MCID: AVD001
MIFTS: 39

Avoidant Personality Disorder malady

Category: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

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Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 10 12 65
Anxious Personality Disorder 10 65
 
Personality Disorders 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:1509
ICD1027 F60.6
ICD9CM29 301.82
SNOMED-CT59 191771004, 37746008
MeSH36 D010554
NCIt42 C92636
UMLS65 C0004444, C0494415, C0031212

Summaries for Avoidant Personality Disorder

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Disease Ontology:10 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary: Avoidant Personality Disorder, also known as anxious personality disorder, is related to obsessive-compulsive personality disorder and intermittent explosive disorder. An important gene associated with Avoidant Personality Disorder is SPRN (Shadow Of Prion Protein Homolog (Zebrafish)), and among its related pathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Syndecan-4-mediated signaling events. Affiliated tissues include brain, bone and lymph node, and related mouse phenotypes are liver/biliary system and behavior/neurological.

Wikipedia:68 Avoidant personality disorder (AvPD), also known as anxious personality disorder, is a Cluster C... more...

Related Diseases for Avoidant Personality Disorder

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Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1obsessive-compulsive personality disorder33.6MAOA, MME, WASF1, WASF2
2intermittent explosive disorder33.1HTR2A, MAOA
3personality disorder29.5APP, CCL5, CCR5, CRH, CTSB, CXCL12
4borderline personality disorder12.8
5antisocial personality disorder12.7
6schizotypal personality disorder12.7
7dependent personality disorder12.7
8schizoid personality disorder12.7
9paranoid personality disorder12.7
10histrionic personality disorder12.7
11narcissistic personality disorder12.6
12multiple personality disorder12.6
13cyclothymic disorder11.3
14ring chromosome 14 syndrome10.5HTR2A, MAOA
15ehrlichiosis10.4HTR2A, MAOA
16steatorrhea10.4CTSB, HTR2A
17brachial plexus neoplasm10.4HTR2A, MAOA
18kleptomania10.3HTR2A, MAOA
19hepatitis10.3
20endotheliitis10.3
21aids dysmorphic syndrome10.3CXCL12, CXCR4
22perrault syndrome10.3HTR2A, MAOA
23vogt-koyanagi-harada disease10.3CRH, HTR2A, MAOA
24hairy cell leukemia10.3CRH, HTR2A, MAOA
25whim syndrome10.3CXCL12, CXCR4
26tympanosclerosis10.3CRH, HTR2A, MAOA
27chronic mucocutaneous candidiasis10.3CRH, HTR2A, MAOA
28malignant hyperthermia10.3CRH, HTR2A, MAOA
29mental depression10.3CRH, HTR2A, MAOA
30may-hegglin anomaly10.3CRH, HTR2A, MAOA
31encephalomalacia10.3CRH, HTR2A, MAOA
32hyperglobulinemic purpura10.3CRH, HTR2A, MAOA
33tuberculosis10.3
34malignant pleural mesothelioma10.3CCL5, CCR5
35nodular episcleritis10.3CRH, HTR2A
36adrenal cortical adenoma10.2APP, HTR2A, MAOA
37birdshot chorioretinopathy10.2APP, CRH
38ischemic heart disease10.2CXCL12, CXCR5
39ovarian mixed germ cell neoplasm10.2HTR2A, MAOA
40colorectal cancer10.2
41cystic fibrosis10.2
42hepatitis c10.2
43epidermolysis bullosa10.2
44atopic dermatitis10.1APP, CCR5, HTR2A
45urethral diverticulum10.1CCL5, CCR5, CXCR4
46small intestine cancer10.1CTSB, MME
47lung cancer10.0
48breast cancer10.0
49hepatitis c virus10.0
50rothmund-thomson syndrome10.0

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to avoidant personality disorder

Symptoms for Avoidant Personality Disorder

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Drugs & Therapeutics for Avoidant Personality Disorder

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Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotineapproved97354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(R,S)-nicotine
(RS)-nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(┬▒)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
American Fare Nicotine Transdermal System
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Careone Nicotine Transdermal System Step 1
Careone Nicotine Transdermal System Step 2
Careone Nicotine Transdermal System Step 3
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Equaline Nicotine Transdermal System STEP 1
Exchange Select Nicotine Transdermal System STEP 3
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
Habitrol Patch Nicotine Transdermal System, Step 1
Habitrol Patch Nicotine Transdermal System, Step 2
Habitrol Patch Nicotine Transdermal System, Step 3
Healthmart Nicotine Transdermal System STEP 1
Healthmart Nicotine Transdermal System STEP 2
Healthmart Nicotine Transdermal System STEP 3
Kroger Nicotine Transdermal System STEP 1
Kroger Nicotine Transdermal System STEP 2
Kroger Nicotine Transdermal System STEP 3
L(-)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
L-Nicotine
LS-202
Leader Nicotine
Leader Nicotine Transdermal System STEP 1
Leader Nicotine Transdermal System STEP 2
Leader Nicotine Transdermal System STEP 3
MLS001055457
 
MLS001335905
Mach-Nic
Meijer Nicotine Transdermal System STEP 2
Meijer Nicotine Transdermal System Step 1
Meijer Nicotine Transdermal System Step 3
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm CQ
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine TRANSDERMAL SYSTEM
Nicotine Transdermal System PATCH KIT
Nicotine Transdermal System STEP 1
Nicotine Transdermal System STEP 2
Nicotine Transdermal System STEP 3
Nicotine Transdermal System Step 1
Nicotine Transdermal System Step 2
Nicotine Transdermal System Step 3
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotine transdermal system
Nicotrol
Nicotrol (professional Sample)
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
Rite Aid Nicotine Transdermal System Step 1
Rite Aid Nicotine Transdermal System Step 2
Rite Aid Nicotine Transdermal System Step 3
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Safeway Nicotine Transdermal System STEP 1
Safeway Nicotine Transdermal System STEP 2
Safeway Nicotine Transdermal System STEP 3
Smart Sense Nicotine
Sunmark Nicotine
Sunmark Nicotine Transdermal System STEP 1
Sunmark Nicotine Transdermal System STEP 2
Sunmark Nicotine Transdermal System STEP 3
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Group Based Schema Therapy in the Treatment of Personality DisordersCompletedNCT00247234Phase 2
2Developing Genetic Education for Smoking CessationCompletedNCT01186016
3Changes in the Brain as Borderline Patients Learn to Regulate Their EmotionsRecruitingNCT02465697

Search NIH Clinical Center for Avoidant Personality Disorder


Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

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Anatomical Context for Avoidant Personality Disorder

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MalaCards organs/tissues related to Avoidant Personality Disorder:

33
Brain, Bone, Lymph node, Bone marrow, Breast, B cells, Endothelial

Animal Models for Avoidant Personality Disorder or affiliated genes

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MGI Mouse Phenotypes related to Avoidant Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2CCR5, CRH, CXCL12, MME, WASF1, WASF2
2MP:00053867.7APP, CCR5, CRH, CTSB, FMR1, HTR2A
3MP:00053697.4APP, CCR5, CXCL12, CXCR4, HTR2A, WASF1
4MP:00036316.7APP, CCR5, CRH, CTSB, CXCL12, CXCR4
5MP:00053876.4APP, CCL5, CCR5, CRH, CTSB, CXCL12

Publications for Avoidant Personality Disorder

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Articles related to Avoidant Personality Disorder:

(show top 50)    (show all 84)
idTitleAuthorsYear
1
Hydroxychloroquine de Novo-Induced Psoriasis in a Patient With Lichen Planus Pigmentosus. (26861533)
2015
2
The benefits of staying active in old age: physical activity counteracts the negative influence of PICALM, BIN1, and CLU risk alleles on episodic memory functioning. (24660791)
2014
3
Susac syndrome: an Italian case. (23828373)
2013
4
Tetraparesia with areflexia revealing cerebral venous thrombosis. (23394852)
2013
5
Myoclonus-dystonia and Silver-Russell syndrome resulting from maternal uniparental disomy of chromosome 7. (23237735)
2013
6
Shortness: an unknown phenotype of multiple endocrine neoplasia type 1. (23828958)
2013
7
Embodiment and dementia - Dance movement psychotherapists respond. (24337633)
2013
8
Subjective binge eating with compensatory behaviors: a variant presentation of bulimia nervosa. (22911884)
2013
9
Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases. (22088212)
2012
10
Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. (22952453)
2012
11
A functional variant in the MTOR promoter modulates its expression and is associated with renal cell cancer risk. (23209702)
2012
12
Association of renal resistive index with target organ damage in essential hypertension. (22874890)
2012
13
Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients. (22144829)
2011
14
Surfactant protein-A (SP-A) selectively inhibits prostaglandin F2alpha (PGF2alpha) production in term decidua: implications for the onset of labor. (21270323)
2011
15
Pancreatic panniculitis: a cutaneous presentation as an initial clue to the diagnosis of pancreatic cancer. (21721456)
2011
16
Recurrent bilateral orbital myositis: case report and review of the literature. (21575325)
2011
17
Down-regulation of c-Myc expression inhibits the invasion of bile duct carcinoma cells. (21557726)
2011
18
The Valued People Project: users' views on learning disability nursing. (21240134)
2011
19
Epithelial induction of porcine suppressor of cytokine signaling 2 (SOCS2) gene expression in response to Entamoeba histolytica. (20045027)
2010
20
A preterm infant with semilobar holoprosencephaly and hydrocephalus: a case report. (20180992)
2010
21
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
22
Multiple sulfatase deficiency in a Turkish family resulting from a novel mutation. (18509892)
2008
23
Beneficial effects of adalimumab on biomarkers reflecting structural damage in patients with ankylosing spondylitis. (18785308)
2008
24
Transitional cell carcinoma of the bladder in first decade of life. (18813937)
2008
25
Surface modifications of Nitinol for biomedical applications. (18815014)
2008
26
Human gene mutations. Gene symbol: SLC7A9. Disease: cystinuria. (18386345)
2007
27
Age-related penetrance of endocrine tumours in multiple endocrine neoplasia type 1 (MEN1): a multicentre study of 258 gene carriers. (17590169)
2007
28
Alphavbeta6 integrin in wound healing and cancer of the oral cavity. (16393247)
2006
29
The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants. (16434690)
2006
30
False aneurysm formation at proximal and distal ends of a stent graft: a rare complication in the repair of endovascular thoracic aortic aneurysm. (16763544)
2006
31
An assessment of transmission disequilibrium between quantitative measures of childhood problem behaviors and DRD2/Taql and DRD4/48bp-repeat polymorphisms. (15319572)
2004
32
Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. (15314226)
2004
33
Melphalan-mobilized blood stem cell components contain minimal clonotypic myeloma cell contamination. (12649134)
2003
34
In vitro model of suicide gene therapy for alpha-fetoprotein-producing gastric cancer. (14666679)
2003
35
Hormonal therapy in postmenopausal women with breast cancer. (12759523)
2003
36
Evidence that hepatic lipase and endothelial lipase have different substrate specificities for high-density lipoprotein phospholipids. (14622025)
2003
37
Incidence of differentiated cancer in nodular goiter. (12235469)
2002
38
Tuberculum sellae meningioma: a report on management on the basis of a surgical experience with 70 patients. (12445340)
2002
39
Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta. (12450065)
2002
40
KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. (11703931)
2001
41
Gating kinetics of potassium channel and effects of nerve growth factors in PC12 cells analyzed with fractal model. (11741513)
2001
42
Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription. (11691937)
2001
43
Biochemical detection and monitoring of alcohol abuse and abstinence. (11732647)
2001
44
Deep venous thrombosis: epidemiologic, diagnostic and therapeutic aspects]. (9675960)
1998
45
Plasma patterns of tumor necrosis factor-alpha (TNF) and TNF soluble receptors during acute meningococcal infections and the effect of plasma exchange. (9564476)
1998
46
A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. (8662874)
1996
47
Prenatal diagnosis of mitochondrial fatty acid oxidation defects. (8650121)
1996
48
Platypnea related to constrictive pericarditis. (7874980)
1995
49
Spondylolysis and spondylolisthesis in military parachutists. (1780073)
1991
50
Glanders. (15431372)
1950

Variations for Avoidant Personality Disorder

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Expression for genes affiliated with Avoidant Personality Disorder

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Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for genes affiliated with Avoidant Personality Disorder

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GO Terms for genes affiliated with Avoidant Personality Disorder

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Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:000590110.0CTSB, HTR2A

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:007072310.3CCL5, CCR5
2positive regulation of monocyte chemotaxisGO:009002610.2CCL5, CXCL12
3positive regulation of T cell migrationGO:200040610.1CCL5, CXCL12
4dendritic cell chemotaxisGO:000240710.0CCL5, CXCR4
5negative regulation of cell deathGO:00605489.6CCL5, CRH, CTSB
6Rac protein signal transductionGO:00166019.4WASF1, WASF2
7chemokine-mediated signaling pathwayGO:00700989.2CCL5, CCR5, CXCL12
8G-protein coupled receptor signaling pathwayGO:00071868.7CCL5, CXCL12, CXCR4, CXCR5, HTR2A

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1actin bindingGO:00037799.0CCR5, WASF1, WASF2

Sources for Avoidant Personality Disorder

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet