MCID: AVD001
MIFTS: 35

Avoidant Personality Disorder malady

Mental diseases category

Aliases & Classifications for Avoidant Personality Disorder

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Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 10 12 65
 
Anxious Personality Disorder 10 65


Classifications:



External Ids:

Disease Ontology10 DOID:1509
ICD9CM29 301.82
SNOMED-CT59 37746008, 191771004
MeSH36 D010554
ICD1027 F60.6

Summaries for Avoidant Personality Disorder

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Disease Ontology:10 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary: Avoidant Personality Disorder, also known as anxious personality disorder, is related to borderline personality disorder and personality disorder. An important gene associated with Avoidant Personality Disorder is SPRN (Shadow Of Prion Protein Homolog (Zebrafish)), and among its related pathways are Syndecan-4-mediated signaling events and A-beta Plaque Formation and APP Metabolism. Affiliated tissues include testes and amygdala, and related mouse phenotypes are other and muscle.

Wikipedia:68 Avoidant personality disorder (AvPD), also known as anxious personality disorder, is a Cluster C... more...

Related Diseases for Avoidant Personality Disorder

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Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1borderline personality disorder29.8MAOA, MME, WASF1, WASF2
2personality disorder11.1
3social phobia10.9
4anxiety disorder10.5
5ring chromosome 14 syndrome10.3HTR2A, MAOA
6schizophrenia10.3
7bulimia nervosa10.3
8phosphorus metabolism disease10.2HTR2A, MAOA
9uterine sarcoma10.2CXCL12, CXCR4
10ischemic retinopathy10.2CCL5, CCR5
11frey syndrome10.2HTR2A, MAOA
12spastic ectropion10.2CRH, HTR2A, MAOA
13postsurgical hypothyroidism10.2CRH, HTR2A, MAOA
14pericardial tuberculosis10.2CRH, HTR2A, MAOA
15bacterial vaginosis10.2CRH, HTR2A, MAOA
16whim syndrome10.2CXCL12, CXCR4
17hodgkin's lymphoma, lymphocytic-histiocytic predominance10.2CRH, HTR2A, MAOA
18may-hegglin anomaly10.2CRH, HTR2A, MAOA
19aortic aneurysm10.2CRH, HTR2A, MAOA
20aids dysmorphic syndrome10.2CXCL12, CXCR4
21spastic entropion10.2HTR2A, MAOA
22familial glomangioma10.2HTR2A, MAOA
23rubella10.2CCL5, CCR5
24infantile-onset ascending hereditary spastic paralysis10.1CXCL12, MME
25motion sickness10.1CRH, HTR2A, MAOA
26obsessive-compulsive disorder10.1
27intermittent explosive disorder10.1
28schizotypal personality disorder10.1
29obsessive-compulsive personality disorder10.1
30eating disorder10.1
31pediculus humanus corporis infestation10.1CRH, HTR2A
32ischemic heart disease10.1CXCR4, CXCR5
33polyradiculopathy10.1CCL5, CXCL12, CXCR4
34viral meningitis10.1CCL5, CCR5, CXCR4
35hydrocele10.0CCL5, CCR5, CXCL12, CXCR4
36endometrial adenocarcinoma9.9CRH, HTR2A, MAOA, WASF1
37nicotine dependence, protection against9.9HTR2A, MAOA, WASF1, WASF2
38lymphoma, non-hodgkin9.8CXCL12, CXCR4, CXCR5, MME
39epidermolysis bullosa9.7CCL5, WDTC1
40mesenchymal cell neoplasm9.7CRH, HTR2A, MAOA, WASF1, WASF2
41major depressive disorder and accelerated response to antidepressant drug treatment9.7CRH, HTR2A, MAOA, WASF1, WASF2
42alzheimer disease9.7APP, CRH, CTSB, HTR2A, MME
43myocardial infarction9.7CCL5, CCR5, CXCL12, CXCR4, HTR2A, MME
44dependent personality disorder9.4CCL5, CXCL12, HTR2A, WASF1, WASF2, WDTC1
45stress polycythemia8.0APP, CCL5, CCR5, CRH, CTSB, CXCL12

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to avoidant personality disorder

Symptoms for Avoidant Personality Disorder

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Drugs & Therapeutics for Avoidant Personality Disorder

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Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotineapproved92354-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(R,S)-nicotine
(RS)-nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(┬▒)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
American Fare Nicotine Transdermal System
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Careone Nicotine Transdermal System Step 1
Careone Nicotine Transdermal System Step 2
Careone Nicotine Transdermal System Step 3
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Equaline Nicotine Transdermal System STEP 1
Exchange Select Nicotine Transdermal System STEP 3
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
Habitrol Patch Nicotine Transdermal System, Step 1
Habitrol Patch Nicotine Transdermal System, Step 2
Habitrol Patch Nicotine Transdermal System, Step 3
Healthmart Nicotine Transdermal System STEP 1
Healthmart Nicotine Transdermal System STEP 2
Healthmart Nicotine Transdermal System STEP 3
Kroger Nicotine Transdermal System STEP 1
Kroger Nicotine Transdermal System STEP 2
Kroger Nicotine Transdermal System STEP 3
L(-)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
L-Nicotine
LS-202
Leader Nicotine
Leader Nicotine Transdermal System STEP 1
Leader Nicotine Transdermal System STEP 2
Leader Nicotine Transdermal System STEP 3
MLS001055457
 
MLS001335905
Mach-Nic
Meijer Nicotine Transdermal System STEP 2
Meijer Nicotine Transdermal System Step 1
Meijer Nicotine Transdermal System Step 3
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm CQ
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine TRANSDERMAL SYSTEM
Nicotine Transdermal System PATCH KIT
Nicotine Transdermal System STEP 1
Nicotine Transdermal System STEP 2
Nicotine Transdermal System STEP 3
Nicotine Transdermal System Step 1
Nicotine Transdermal System Step 2
Nicotine Transdermal System Step 3
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotine transdermal system
Nicotrol
Nicotrol (professional Sample)
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
Rite Aid Nicotine Transdermal System Step 1
Rite Aid Nicotine Transdermal System Step 2
Rite Aid Nicotine Transdermal System Step 3
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Safeway Nicotine Transdermal System STEP 1
Safeway Nicotine Transdermal System STEP 2
Safeway Nicotine Transdermal System STEP 3
Smart Sense Nicotine
Sunmark Nicotine
Sunmark Nicotine Transdermal System STEP 1
Sunmark Nicotine Transdermal System STEP 2
Sunmark Nicotine Transdermal System STEP 3
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Group Based Schema Therapy in the Treatment of Personality DisordersCompletedNCT00247234Phase 2
2Developing Genetic Education for Smoking CessationCompletedNCT01186016
3Changes in the Brain as Borderline Patients Learn to Regulate Their EmotionsRecruitingNCT02465697

Search NIH Clinical Center for Avoidant Personality Disorder

Genetic Tests for Avoidant Personality Disorder

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Anatomical Context for Avoidant Personality Disorder

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MalaCards organs/tissues related to Avoidant Personality Disorder:

33
Testes, Amygdala

Animal Models for Avoidant Personality Disorder or affiliated genes

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MGI Mouse Phenotypes related to Avoidant Personality Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.3APP, CRH, CTSB, MME
2MP:00053698.0APP, CCR5, CXCL12, CXCR4, HTR2A, WASF1
3MP:00053867.5APP, CCR5, CRH, CTSB, FMR1, HTR2A
4MP:00053877.2APP, CCL5, CCR5, CRH, CTSB, CXCL12
5MP:00053786.8APP, CRH, CTSB, CXCR4, FMR1, SPRN
6MP:00036316.4APP, CCR5, CRH, CTSB, CXCL12, CXCR4

Publications for Avoidant Personality Disorder

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Articles related to Avoidant Personality Disorder:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. (26569037)
2015
2
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. (26129819)
2015
3
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. (26481549)
2015
4
Attachment styles in patients with avoidant personality disorder compared with social phobia. (26332087)
2015
5
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. (25035563)
2014
6
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. (25215596)
2014
7
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. (24275960)
2014
8
Brief Cognitive Therapy for Avoidant Personality Disorder. (24377411)
2013
9
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
10
Personality functioning in patients with avoidant personality disorder and social phobia. (23786266)
2013
11
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. (24343980)
2013
12
Social Phobia and Avoidant Personality Disorder: Similar but Different? (23398095)
2013
13
A parallel process growth model of avoidant personality disorder symptoms and personality traits. (22506627)
2013
14
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? (22705954)
2012
15
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. (22448805)
2011
16
Changes in defensive functioning in a case of avoidant personality disorder. (22402007)
2010
17
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? (19536877)
2010
18
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. (20677852)
2010
19
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. (20053537)
2010
20
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
21
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? (19728570)
2009
22
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. (19516064)
2009
23
Avoidant personality disorder and its relationship to social phobia. (19187715)
2009
24
The impact of avoidant personality disorder on psychosocial impairment is substantial. (19333817)
2009
25
Predictors of withdrawal: possible precursors of avoidant personality disorder. (19583885)
2009
26
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. (17618526)
2008
27
The relationship between avoidant personality disorder and social phobia: a population-based twin study. (17974938)
2007
28
Psychoanalysis with avoidant personality disorder: A systematic case study. (22122163)
2007
29
The relationship between avoidant personality disorder and social phobia. (17560956)
2007
30
Integrated wilderness therapy for avoidant personality disorder. (16923635)
2006
31
A comparison of publication trends on avoidant personality disorder and social phobia. (16962667)
2006
32
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
33
Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function. (14971632)
2004
34
Childhood antecedents of avoidant personality disorder: a retrospective study. (12960713)
2003
35
Personality and mood correlates of avoidant personality disorder. (12004493)
2002
36
The influence on treatment gain of comorbid avoidant personality disorder in patients with social phobia. (11838470)
2002
37
Generalized social phobia versus avoidant personality disorder: differences in psychopathology, personality traits, and social and occupational functioning. (11043888)
2000
38
The relationship of social phobia to avoidant personality disorder: a proposal to reclassify avoidant personality disorder based on clinical empirical findings. (10960264)
2000
39
Multimodal comparisons of social phobia subtypes and avoidant personality disorder. (10372342)
1999
40
Social phobia, avoidant personality disorder and atypical depression: co-occurrence and clinical implications. (9153683)
1997
41
Avoidant personality disorder and taijin kyoufu: sociocultural implications of the WHO/ADAMHA International Study of Personality Disorders in Japan. (8739661)
1996
42
The treatment of avoidant personality disorder by social skills training in the clinic or in real-life settings. (7834593)
1994
43
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992
44
Social phobia: a comparison of specific and generalized subtypes and avoidant personality disorder. (1583227)
1992
45
Generalized social phobia versus avoidant personality disorder: a commentary on three studies. (1583229)
1992
46
The relationship of social phobia subtypes and avoidant personality disorder. (1778076)
1991
47
A test of the therapeutic mechanism in social skills training with avoidant personality disorder. (2592963)
1989
48
Perception of early parenting by patients diagnosed avoidant personality disorder: a test of the overprotection hypothesis. (2596337)
1989
49
Psychopharmacological treatment of avoidant personality disorder. (2684499)
1989
50
Clinical phobias and avoidant personality disorder among alcoholics admitted to an alcoholism rehabilitation setting. (3791123)
1986

Variations for Avoidant Personality Disorder

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Expression for genes affiliated with Avoidant Personality Disorder

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Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for genes affiliated with Avoidant Personality Disorder

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GO Terms for genes affiliated with Avoidant Personality Disorder

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Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1SCAR complexGO:00312099.7WASF1, WASF2
2external side of plasma membraneGO:00098979.1CCR5, CTSB, CXCL12, CXCR5

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:007072310.4CCL5, CCR5
2entry into host cellGO:003026010.3CCR5, CXCR4
3positive regulation of calcium ion importGO:009028010.3CRH, CXCL12
4positive regulation of monocyte chemotaxisGO:009002610.3CCL5, CXCL12
5positive regulation of T cell migrationGO:200040610.2CCL5, CXCL12
6ameboidal-type cell migrationGO:000166710.1CXCL12, WASF2
7neutrophil activationGO:004211910.0CCL5, CXCR4
8positive regulation of cytosolic calcium ion concentrationGO:000720410.0CCR5, CXCR4, HTR2A
9negative regulation of cell deathGO:006054810.0CCL5, CRH, CTSB
10Rac protein signal transductionGO:001660110.0WASF1, WASF2
11lamellipodium morphogenesisGO:007267310.0WASF1, WASF2
12viral entry into host cellGO:00467189.8CCR5, CTSB, CXCR4, HTR2A
13dendritic cell chemotaxisGO:00024079.8CCL5, CCR5, CXCR4
14cellular response to cytokine stimulusGO:00713459.6CCL5, CXCR4, MME
15cellular calcium ion homeostasisGO:00068749.6CCL5, CXCL12, HTR2A
16inflammatory responseGO:00069549.5CCL5, CCR5, CRH, CXCR4
17chemotaxisGO:00069359.2CCL5, CCR5, CXCL12, CXCR5
18immune responseGO:00069559.2CCL5, CCR5, CXCL12, CXCR5
19response to virusGO:00096159.1CCL5, CXCL12, CXCR4
20chemokine-mediated signaling pathwayGO:00700988.9CCL5, CCR5, CXCL12, CXCR4, CXCR5
21G-protein coupled receptor signaling pathwayGO:00071868.4CCL5, CCR5, CXCL12, CXCR4, CXCR5, HTR2A

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:005137810.6HTR2A, MAOA
2coreceptor activityGO:001502610.1CCR5, CXCR4
3chemoattractant activityGO:004205610.0CCL5, CXCL12
4chemokine receptor bindingGO:004237910.0CCL5, CXCL12
5virus receptor activityGO:00016189.9CCR5, CXCR4, HTR2A
6C-X-C chemokine receptor activityGO:00164949.7CXCR4, CXCR5
7protein complex bindingGO:00324039.1CTSB, HTR2A, WASF1, WASF2
8actin bindingGO:00037798.7CCR5, CXCR4, WASF1, WASF2

Sources for Avoidant Personality Disorder

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet