MCID: AVD001
MIFTS: 38

Avoidant Personality Disorder malady

Category: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

About this section

Aliases & Descriptions for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 11 13 66
Anxious Personality Disorder 11 66
 
Personality Disorders 37

Classifications:



External Ids:

Disease Ontology11 DOID:1509
ICD1028 F60.6
ICD9CM30 301.82
SNOMED-CT60 191771004, 37746008
MeSH37 D010554
NCIt43 C92636

Summaries for Avoidant Personality Disorder

About this section
Disease Ontology:11 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary: Avoidant Personality Disorder, also known as anxious personality disorder, is related to personality disorder and familial sick sinus syndrome. An important gene associated with Avoidant Personality Disorder is AMY1A (Amylase, Alpha 1A (Salivary)), and among its related pathways are Syndecan-4-mediated signaling events and A-beta Pathways: Plaque Formation and APP Metabolism. Affiliated tissues include brain, testes and amygdala, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:69 Avoidant personality disorder (AvPD), also known as anxious personality disorder, is a Cluster C... more...

Related Diseases for Avoidant Personality Disorder

About this section

Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
idRelated DiseaseScoreTop Affiliating Genes
1personality disorder10.7
2familial sick sinus syndrome10.6CCL5, CCR5
3intrahepatic gall duct cancer10.5CRH, MAOA
4social phobia10.5
5nonencapsulated sclerosing carcinoma10.4AMY1A, MAOA
6glycogen storage disease viii10.4FLNA, WASF2
7ischemic optic neuropathy10.4CXCL12, CXCR4
8taylor's syndrome10.3CCL5, CCR5, CXCR4
9disease_ontology10.3CXCL12, CXCR4
10whim syndrome10.2CXCL12, CXCR4
11anxiety disorder10.1
12heart leiomyosarcoma10.1CCL5, CCR5, CXCL12, CXCR4
13schizophrenia9.9
14bulimia nervosa9.9
15eating disorder9.9
16obsessive-compulsive disorder9.7
17schizotypal personality disorder9.7
18borderline personality disorder9.7
19obsessive-compulsive personality disorder9.7
20intermittent explosive disorder9.7
21substance abuse9.7
22parkinsonism-dystonia, infantile9.6MAOA, WASF1, WASF2
23smoking as a quantitative trait locus 19.6CXCL12, CXCR4, CXCR5, MME
24gemistocytic astrocytoma9.5APP, CCL5, WDTC1
25chronic myocardial ischemia9.4CXCL12, CXCR4, CXCR5, MME
26hypoglycemic coma9.4CRH, MAOA, WASF1, WASF2
27multiple personality disorder9.4MAOA, MME, WASF1, WASF2
28avoidant personality disorder9.2CRH, FMR1, MAOA, WASF1, WASF2
29chronic gonorrhea of cervix4.3AMY1A, AMY1B, AMY1C, APP, C6orf15, CCL5

Comorbidity relations with Avoidant Personality Disorder via Phenotypic Disease Network (PDN):


Major Depressive Disorder and Accelerated Response to Antidepressant Drug TreatmentDependent Personality Disorder
Dysthymic Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to avoidant personality disorder

Symptoms for Avoidant Personality Disorder

About this section

Drugs & Therapeutics for Avoidant Personality Disorder

About this section

Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nicotine101654-11-5942, 89594
Synonyms:
(−
(+)-Nicotine
(+-)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(+-)-Nicotine
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(-)-Nicotine
(-)-Nicotine solution
(2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine
(R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
(R,S)-Nicotine
(R,S)-nicotine
(RS)-nicotine
(S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE
(S)-(-)-Nicotine
(S)-3-(1-methylpyrrolidin-2-yl)pyridine
(S)-3-(N-methylpyrrolidin-2-yl)pyridine
(S)-Nicotine
(┬▒)-nicotine
)-1-Methyl-2-(3-pyridyl)pyrrolidine
)-Nicotine
)-Nicotine solution
1-Methyl-2-(3-pyridal)-Pyrrolidine
1-Methyl-2-(3-pyridal)-pyrrolidene
1-Methyl-2-(3-pyridiyl)pyrrolidine
1-Methyl-2-(3-pyridyl)pyrrolidine
1uw6
2'-beta-H-Nicotine
3-(1-Methyl-2-pyrollidinyl)pyridine
3-(1-Methyl-2-pyrrolidinyl)-Pyridine
3-(1-Methyl-2-pyrrolidinyl)pyridine
3-(1-Methylpyrrolidin-2-yl)pyridine
3-(2-(N-methylpyrrolidinyl))pyridine
3-(N-Methylpyrollidino)pyridine
3-(N-Methylpyrrolidino)pyridine
3-N-Methylpyrrolidine
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
36733_FLUKA
36733_RIEDEL
434F7990-3240-4A43-ACEC-E6CC1E495FA0
46343_FLUKA
46343_RIEDEL
54-11-5
AC1L3I79
AC1Q3ZOC
AI3-03424
BB_NC-0777
BIDD:GT0599
BRD-K05395900-322-02-1
Black Leaf
Black Leaf 40
C00745
CCRIS 1637
CHEBI:17688
CHEMBL3
CID89594
CPD000059074
Campbell's Nico-Soap
Caswell No. 597
Commit
D-Nicotine
D03365
DL-tetrahydronicotyrine
Destruxol
Destruxol Orchid Spray
EINECS 200-193-3
ENT 3,424
EPA Pesticide Chemical Code 056702
Emo-Nik
Flux Maag
Fumeto bac
Fumetobac
HSDB 1107
Habitrol
Habitrol (TN)
L(-)-nicotine
L-3-(1-Methyl-2-pyrrolidyl)pyridine
 
L-Nicotine
LS-202
MLS001055457
MLS001335905
Mach-Nic
Methyl-2-pyrrolidinyl)pyridine
Micotine
MolPort-000-744-731
N3876_SIGMA
N5511_FLUKA
N5511_SIGMA
NCGC00090693-01
NCGC00090693-02
NCGC00090693-03
NCGC00090693-04
NCGC00090693-05
NCGC00090693-06
NCGC00090693-07
NCT
NICOTINE AND SALTS
NSC 5065
NSC97238
Niagara P.A. Dust
Nic-Sal
Nico-Dust
Nico-Fume
Nicocide
Nicoderm
Nicoderm Cq
Nicoderm Patch
Nicorette
Nicorette Plus
Nicotin
Nicotina
Nicotina [Italian]
Nicotine
Nicotine (USP)
Nicotine (compounds related to)
Nicotine Alkaloid
Nicotine Patch
Nicotine Polacrilex
Nicotine [BSI:ISO]
Nicotine [UN1654]
Nicotine [UN1654] [Poison]
Nicotine [USAN]
Nicotrol
Nicotrol Inhaler
Nicotrol Ns
Nictoine patch
Nikotin
Nikotin [German]
Nikotyna
Nikotyna [Polish]
Ortho N-4 Dust
Ortho N-5 Dust
PDSP1_000113
PDSP1_000465
PDSP2_000463
PDSP2_000555
Prostep
R)-(+)-Nicotine
RCRA waste no. P075
RCRA waste number P075
SAM002564224
SDCCGMLS-0066911.P001
SMR000059074
Tendust
Transdermal Nicotine
UN1654
a -N-Methylpyrrolidine
a-N-Methylpyrrolidine
alpha-N-Methylpyrrolidine
beta-Pyridyl-alpha-N-methyl pyrrolidine
beta-Pyridyl-alpha-N-methylpyrrolidine
bmse000105
delta-Nicotine
nicotine
nicotine replacement patch

Interventional clinical trials:

idNameStatusNCT IDPhase
1Effectiveness of Group Based Schema Therapy in the Treatment of Personality DisordersCompletedNCT00247234Phase 2
2Developing Genetic Education for Smoking CessationCompletedNCT01186016
3Changes in the Brain as Borderline Patients Learn to Regulate Their EmotionsRecruitingNCT02465697

Search NIH Clinical Center for Avoidant Personality Disorder


Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

About this section

Anatomical Context for Avoidant Personality Disorder

About this section

MalaCards organs/tissues related to Avoidant Personality Disorder:

34
Brain, Testes, Amygdala

Animal Models for Avoidant Personality Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Avoidant Personality Disorder:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.2CCR5, CRH, CXCL12, FLNA, MME, WASF1
2MP:00053877.5APP, CCL5, CCR5, CRH, CTSB, CXCL12
3MP:00036316.6APP, CCR5, CRH, CTSB, CXCL12, CXCR4

Publications for Avoidant Personality Disorder

About this section

Articles related to Avoidant Personality Disorder:

(show top 50)    (show all 92)
idTitleAuthorsYear
1
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. (27227557)
2016
2
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. (26651009)
2016
3
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. (27653504)
2016
4
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. (27505187)
2016
5
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. (27662043)
2016
6
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. (27547506)
2016
7
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. (26129819)
2015
8
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. (26481549)
2015
9
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. (25557644)
2015
10
Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. (25815817)
2015
11
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. (24275960)
2014
12
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. (25451388)
2014
13
Brief Cognitive Therapy for Avoidant Personality Disorder. (24377411)
2013
14
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. (24378158)
2013
15
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. (21308885)
2011
16
Psychotherapy of an older adult with an avoidant personality disorder. (20880430)
2011
17
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? (19536877)
2010
18
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. (20677852)
2010
19
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. (20053537)
2010
20
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. (19683617)
2009
21
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. (19516064)
2009
22
The impact of avoidant personality disorder on psychosocial impairment is substantial. (19333817)
2009
23
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. (17618526)
2008
24
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? (17161000)
2008
25
Psychoanalysis with avoidant personality disorder: A systematic case study. (22122163)
2007
26
The relationship between avoidant personality disorder and social phobia. (17560956)
2007
27
Cognitive-behavioural therapy for avoidant personality disorder. (17197665)
2007
28
Comparison of brief dynamic and cognitive-behavioural therapies in avoidant personality disorder. (16816307)
2006
29
An investigation of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder construct as a prototype category and the psychometric properties of the diagnostic criteria. (16905400)
2006
30
Social phobia and avoidant personality disorder: one spectrum disorder? (15204221)
2004
31
Is avoidant personality disorder more than just social avoidance? (15615668)
2004
32
A case of social phobia and avoidant personality disorder with erectile dysfunction successfully treated with venlafaxine and add-on reboxetine. (15196607)
2004
33
Childhood antecedents of avoidant personality disorder: a retrospective study. (12960713)
2003
34
The influence on treatment gain of comorbid avoidant personality disorder in patients with social phobia. (11838470)
2002
35
Avoidant personality disorder: current status and future directions. (11881158)
2002
36
Generalized social phobia versus avoidant personality disorder: differences in psychopathology, personality traits, and social and occupational functioning. (11043888)
2000
37
Multimodal comparisons of social phobia subtypes and avoidant personality disorder. (10372342)
1999
38
Avoidant personality disorder: empirical support for DSM-IV revisions. (9573517)
1998
39
Social phobia, avoidant personality disorder and atypical depression: co-occurrence and clinical implications. (9153683)
1997
40
The relationship between social phobia and avoidant personality disorder: workshop report 3. (8923120)
1996
41
Avoidant personality disorder and the generalized subtype of social phobia. (1583226)
1992
42
Social phobia: a comparison of specific and generalized subtypes and avoidant personality disorder. (1583227)
1992
43
Validity of the distinction between generalized social phobia and avoidant personality disorder. (1583228)
1992
44
The relationship of social phobia subtypes and avoidant personality disorder. (1778076)
1991
45
MMPI characteristics of the DSM-III-R avoidant personality disorder. (1961830)
1991
46
Attachment pathology and low social skills in avoidant personality disorder: an exploratory study. (2268838)
1990
47
Perception of early parenting by patients diagnosed avoidant personality disorder: a test of the overprotection hypothesis. (2596337)
1989
48
Short-term structured treatment for avoidant personality disorder. (2600246)
1989
49
Psychopathology of social phobia and comparison to avoidant personality disorder. (3805504)
1986
50
A case of social phobia with avoidant personality disorder treated with MAOI. (3709141)
1986

Variations for Avoidant Personality Disorder

About this section

Expression for genes affiliated with Avoidant Personality Disorder

About this section
Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for genes affiliated with Avoidant Personality Disorder

About this section

GO Terms for genes affiliated with Avoidant Personality Disorder

About this section

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth cone filopodiumGO:199081210.6APP, FMR1
2dendritic shaftGO:00431989.9APP, FLNA, FMR1
3SCAR complexGO:00312099.8WASF1, WASF2
4external side of plasma membraneGO:00098979.6CCR5, CTSB, CXCL12, CXCR5
5synapseGO:00452028.8APP, FMR1, MME, WASF1
6extracellular spaceGO:00056157.6AMY1A, AMY1B, AMY1C, APP, CCL5, CRH
7extracellular exosomeGO:00700627.1AMY1A, AMY1B, AMY1C, APP, CTSB, CXCL12

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1response to cholesterolGO:007072310.6CCL5, CCR5
2positive regulation of monocyte chemotaxisGO:009002610.5CCL5, CXCL12
3positive regulation of T cell migrationGO:200040610.5CCL5, CXCL12
4positive regulation of calcium ion importGO:009028010.4CRH, CXCL12
5fusion of virus membrane with host plasma membraneGO:001906410.2CCR5, CXCR4
6telencephalon cell migrationGO:002202910.2CXCL12, CXCR4
7entry into host cellGO:003026010.2CCR5, CXCR4
8dendritic cell chemotaxisGO:000240710.0CCL5, CCR5, CXCR4
9lamellipodium morphogenesisGO:00726739.8WASF1, WASF2
10digestionGO:00075869.8AMY1A, AMY1B, AMY1C
11Rac protein signal transductionGO:00166019.6WASF1, WASF2
12response to virusGO:00096159.4CCL5, CXCL12, CXCR4
13chemotaxisGO:00069359.2CCL5, CCR5, CXCL12, CXCR5
14chemokine-mediated signaling pathwayGO:00700988.8CCL5, CCR5, CXCL12, CXCR4, CXCR5

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine receptor bindingGO:004237910.3CCL5, CXCL12
2alpha-amylase activityGO:00045569.9AMY1A, AMY1B, AMY1C
3C-X-C chemokine receptor activityGO:00164949.7CXCR4, CXCR5
4actin bindingGO:00037798.7CCR5, CXCR4, WASF1, WASF2

Sources for Avoidant Personality Disorder

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet