MCID: AVD001
MIFTS: 43

Avoidant Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

MalaCards integrated aliases for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 12 72 14 69
Anxious Personality Disorder 12 69
Personality Disorders 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1509
ICD10 32 F60.6
ICD9CM 34 301.82
MeSH 41 D010554
NCIt 46 C92636
SNOMED-CT 64 191771004 37746008

Summaries for Avoidant Personality Disorder

Disease Ontology : 12 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary : Avoidant Personality Disorder, also known as anxious personality disorder, is related to disease of mental health and personality disorder, and has symptoms including pseudobulbar behavioral symptoms, restlessness and personality changes. An important gene associated with Avoidant Personality Disorder is AMY1A (Amylase, Alpha 1A (Salivary)), and among its related pathways/superpathways are PAK Pathway and CCR5 Pathway in Macrophages. Affiliated tissues include brain, testes and amygdala, and related phenotypes are liver/biliary system and nervous system

Wikipedia : 72 Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a... more...

Related Diseases for Avoidant Personality Disorder

Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 disease of mental health 28.7 CRH FMR1 MAOA WASF1 WASF2
2 personality disorder 10.7
3 social phobia 10.4
4 whiplash 10.4 CCL5 CCR5
5 phobia, specific 10.4 FMR1 MAOA
6 atypical depressive disorder 10.3 CRH MAOA
7 anxiety 10.3
8 central nervous system leukemia 10.3 CRH MME
9 narcissistic personality disorder 10.1 FLNA WASF2
10 immune deficiency disease 10.1 CCR5 CXCL12 CXCR4
11 aids dementia complex 10.1 CXCL12 CXCR4
12 human immunodeficiency virus infectious disease 10.0 CCL5 CCR5 CXCL12 CXCR4
13 orofacial granulomatosis 10.0 CCL5 CCR5
14 viral infectious disease 10.0 CCL5 CCR5 CXCR4
15 intraocular lymphoma 9.9 CXCL12 CXCR4 CXCR5
16 human immunodeficiency virus type 1 9.9 CCL5 CCR5 CXCL12 CXCR4
17 schizophrenia 9.8
18 bulimia nervosa 1 9.8
19 eating disorder 9.8
20 tobacco addiction 9.7 MAOA WASF1 WASF2
21 obsessive-compulsive disorder 9.7
22 paraphilia disorder 9.7
23 schizotypal personality disorder 9.7
24 borderline personality disorder 9.7
25 obsessive-compulsive personality disorder 9.7
26 intermittent explosive disorder 9.7
27 substance abuse 9.7
28 ring chromosome y syndrome 9.7
29 myocardial infarction 9.7 CCL5 CCR5 CXCL12 CXCR4 MME
30 lymphoma, non-hodgkin, familial 9.6 CXCL12 CXCR4 CXCR5 MME
31 mental depression 9.5 CRH MAOA WASF1 WASF2
32 dependent personality disorder 9.5 MAOA MME WASF1 WASF2

Comorbidity relations with Avoidant Personality Disorder via Phenotypic Disease Network (PDN):


Dependent Personality Disorder Dysthymic Disorder
Major Depressive Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to Avoidant Personality Disorder

Symptoms & Phenotypes for Avoidant Personality Disorder

UMLS symptoms related to Avoidant Personality Disorder:


pseudobulbar behavioral symptoms, restlessness, personality changes, photophobia, sleep disturbances

MGI Mouse Phenotypes related to Avoidant Personality Disorder:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 WASF1 WASF2 CCR5 CRH CXCL12 FLNA
2 nervous system MP:0003631 9.36 SPRN WASF1 WASF2 CCR5 CRH CTSB

Drugs & Therapeutics for Avoidant Personality Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Group Based Schema Therapy in the Treatment of Personality Disorders Completed NCT00247234
2 Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions Completed NCT02465697

Search NIH Clinical Center for Avoidant Personality Disorder

Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

Anatomical Context for Avoidant Personality Disorder

MalaCards organs/tissues related to Avoidant Personality Disorder:

38
Brain, Testes, Amygdala

Publications for Avoidant Personality Disorder

Articles related to Avoidant Personality Disorder:

(show top 50) (show all 98)
# Title Authors Year
1
Avoidant personality disorder and social phobia: Does mindreading make the difference? ( 29096207 )
2018
2
Stability or instability in avoidant personality disorder:Mode fluctuations within schema therapy sessions. ( 28527713 )
2017
3
Examination of DSM-5 Section III avoidant personality disorder in a community sample. ( 28703479 )
2017
4
The fear of being laughed at as additional diagnostic criterion in social anxiety disorder and avoidant personality disorder? ( 29176893 )
2017
5
Group schema therapy versus group cognitive behavioral therapy for social anxiety disorder with comorbid avoidant personality disorder: study protocol for a randomized controlled trial. ( 27717405 )
2016
6
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. ( 27505187 )
2016
7
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. ( 27653504 )
2016
8
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. ( 27155069 )
2016
9
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. ( 26651009 )
2016
10
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. ( 27662043 )
2016
11
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. ( 27744447 )
2016
12
Avoidant Personality Disorder: a Current Review. ( 26830887 )
2016
13
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. ( 27227557 )
2016
14
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. ( 27547506 )
2016
15
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. ( 26481549 )
2015
16
Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25978045 )
2015
17
Attachment styles in patients with avoidant personality disorder compared with social phobia. ( 26332087 )
2015
18
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. ( 26129819 )
2015
19
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. ( 26569037 )
2015
20
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. ( 25557644 )
2015
21
Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25815817 )
2015
22
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. ( 24275960 )
2014
23
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
24
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. ( 25451388 )
2014
25
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. ( 25215596 )
2014
26
A parallel process growth model of avoidant personality disorder symptoms and personality traits. ( 22506627 )
2013
27
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. ( 24378158 )
2013
28
Personality functioning in patients with avoidant personality disorder and social phobia. ( 23786266 )
2013
29
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. ( 24343980 )
2013
30
Social Phobia and Avoidant Personality Disorder: Similar but Different? ( 23398095 )
2013
31
Brief Cognitive Therapy for Avoidant Personality Disorder. ( 24377411 )
2013
32
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? ( 22705954 )
2012
33
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. ( 22448805 )
2011
34
Psychotherapy of an older adult with an avoidant personality disorder. ( 20880430 )
2011
35
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. ( 21308885 )
2011
36
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. ( 20677852 )
2010
37
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. ( 20053537 )
2010
38
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? ( 19536877 )
2010
39
Changes in defensive functioning in a case of avoidant personality disorder. ( 22402007 )
2010
40
Relations among symptoms of social phobia subtypes, avoidant personality disorder, panic, and depression. ( 20171323 )
2010
41
A functionalist perspective on social anxiety and avoidant personality disorder. ( 19825257 )
2009
42
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. ( 19516064 )
2009
43
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? ( 19728570 )
2009
44
The relationship between generalized social phobia and avoidant personality disorder in a national mental health survey. ( 19031488 )
2009
45
The impact of avoidant personality disorder on psychosocial impairment is substantial. ( 19333817 )
2009
46
Predictors of withdrawal: possible precursors of avoidant personality disorder. ( 19583885 )
2009
47
Avoidant personality disorder and its relationship to social phobia. ( 19187715 )
2009
48
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. ( 19683617 )
2009
49
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? ( 17161000 )
2008
50
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome. ( 17618526 )
2008

Variations for Avoidant Personality Disorder

Expression for Avoidant Personality Disorder

Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for Avoidant Personality Disorder

Pathways related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CCL5 CCR5 CXCL12 CXCR4 CXCR5 FLNA
2
Show member pathways
12.61 CCL5 CCR5 CXCL12 CXCR4 CXCR5
3 12.29 CCL5 CXCL12 CXCR4 CXCR5
4
Show member pathways
11.91 CCL5 CCR5 CXCL12 CXCR4 WASF1
5
Show member pathways
11.75 AMY1A AMY1B AMY1C
6 11.54 FLNA WASF1 WASF2
7 11.22 CXCR4 CXCR5 MME
8
Show member pathways
11.09 CCL5 CCR5 CXCL12 CXCR4 CXCR5
9 11.08 AMY1A AMY1B AMY1C
10 10.87 CTSB MME
11 10.82 CCL5 CXCL12 CXCR4
12 10.09 AMY1A AMY1B AMY1C

GO Terms for Avoidant Personality Disorder

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 AMY1A AMY1B AMY1C CTSB CXCL12 CXCR4
2 extracellular region GO:0005576 9.32 AMY1A AMY1B AMY1C C6orf15 CCL5 CRH
3 SCAR complex GO:0031209 8.96 WASF1 WASF2

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to virus GO:0009615 9.69 CCL5 CXCL12 CXCR4
2 digestion GO:0007586 9.61 AMY1A AMY1B AMY1C
3 Rac protein signal transduction GO:0016601 9.52 WASF1 WASF2
4 positive regulation of monocyte chemotaxis GO:0090026 9.49 CCL5 CXCL12
5 positive regulation of calcium ion import GO:0090280 9.48 CRH CXCL12
6 positive regulation of T cell migration GO:2000406 9.46 CCL5 CXCL12
7 fusion of virus membrane with host plasma membrane GO:0019064 9.4 CCR5 CXCR4
8 lamellipodium morphogenesis GO:0072673 9.37 WASF1 WASF2
9 chemotaxis GO:0006935 9.35 CCL5 CCR5 CXCL12 CXCR4 CXCR5
10 dendritic cell chemotaxis GO:0002407 9.33 CCL5 CCR5 CXCR4
11 negative regulation of macrophage apoptotic process GO:2000110 9.32 CCL5 CCR5
12 entry into host cell GO:0030260 9.26 CCR5 CXCR4
13 chemokine-mediated signaling pathway GO:0070098 9.02 CCL5 CCR5 CXCL12 CXCR4 CXCR5

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.65 CCR5 CXCR4 FLNA WASF1 WASF2
2 hydrolase activity, acting on glycosyl bonds GO:0016798 9.61 AMY1A AMY1B AMY1C
3 chemokine receptor activity GO:0004950 9.46 CCR5 CXCR4
4 C-C chemokine binding GO:0019957 9.4 CCR5 CXCR4
5 C-X-C chemokine receptor activity GO:0016494 9.37 CXCR4 CXCR5
6 cation binding GO:0043169 9.33 AMY1A AMY1B AMY1C
7 chemokine receptor binding GO:0042379 9.32 CCL5 CXCL12
8 alpha-amylase activity GO:0004556 9.13 AMY1A AMY1B AMY1C
9 alpha-amylase activity (releasing maltohexaose) GO:0103025 8.8 AMY1A AMY1B AMY1C

Sources for Avoidant Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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