MCID: AXN001
MIFTS: 37

Axonal Neuropathy malady

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Axonal Neuropathy

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Aliases & Descriptions for Axonal Neuropathy:

Name: Axonal Neuropathy 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:7319
SNOMED-CT60 60703000
NCIt43 C27301

Summaries for Axonal Neuropathy

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MalaCards based summary: Axonal Neuropathy is related to charcot-marie-tooth disease, type 1b and hereditary motor and sensory neuropathy via. An important gene associated with Axonal Neuropathy is GAN (Gigaxonin). Affiliated tissues include skin, brain and testes, and related mouse phenotypes are muscle and cellular.

Related Diseases for Axonal Neuropathy

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Diseases in the Axonal Neuropathy family:

Infantile Axonal Neuropathy Severe Infantile Axonal Neuropathy

Diseases related to Axonal Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1charcot-marie-tooth disease, type 1b30.7GDAP1, MFN2, TRPV4
2hereditary motor and sensory neuropathy via30.2C12orf65, MFN2, PMP22
3charcot-marie-tooth disease, type 1f29.9GDAP1, MFN2, PMP22, TRPV4
4giant axonal neuropathy12.4
5neuromyotonia and axonal neuropathy, autosomal recessive12.3
6spinocerebellar ataxia, autosomal recessive with axonal neuropathy12.3
7acute motor axonal neuropathy12.2
8gars-associated axonal neuropathy12.1
9giant axonal neuropathy 2, autosomal dominant12.1
10infantile axonal neuropathy12.1
11severe infantile axonal neuropathy12.1
12acute motor-sensory axonal neuropathy12.1
13spinocerebellar ataxia with axonal neuropathy type 212.0
14moebius axonal neuropathy hypogonadism12.0
15severe early-onset axonal neuropathy due to nefl deficiency12.0
16moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome11.9
17microcephaly-complex motor and sensory axonal neuropathy syndrome11.9
18severe early-onset axonal neuropathy due to mfn2 deficiency11.9
19giant axonal neuropathy-111.5
20ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia11.2
21neuronopathy, distal hereditary motor, type vi11.2
22neuropathy11.0
23spinocerebellar ataxia, autosomal recessive 110.9
24spinocerebellar ataxia 510.9
25spinocerebellar ataxia 410.9
26keratoderma palmoplantar spastic paralysis10.9
27infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome10.9
28spinal muscular atrophy with respiratory distress type 210.9
29ciliary dyskinesia, primary, 1310.6GAN, MIR4720
30hfe-associated hereditary hemochromatosis10.5DCAF8, GAN, MIR4720
31hypertonia10.3MFN2, PMP22
32prop1-related combined pituitary hormone deficiency10.3C10orf2, POLG
33perrault syndrome 510.3C10orf2, SLC25A4
34deafness, autosomal dominant 3010.3C10orf2, POLG
35ataxia10.3
36trachea leiomyoma10.3MFN2, PMP22
37spasticity10.2
38charcot-marie-tooth neuropathy type 2a10.2GDAP1, LMNA, MFN2, TRPV4
39paraplegia10.2
40mitochondrial dna depletion syndrome 710.1
41charcot-marie-tooth disease, axonal, type 2s10.1
42thrombophilia due to antithrombin iii deficiency10.1GDAP1, MFN2, PMP22, TRPV4
43occupational dermatitis10.1GDAP1, MFN2, PMP22, TRPV4
44hepatitis10.1
45neuronitis10.1
46encephalopathy10.1
47spastic paraplegia 56, autosomal recessive10.0
48neuropathy, hereditary motor and sensory, type vib10.0
49hereditary motor and sensory neuropathy, type iic10.0
50charcot-marie-tooth disease, dominant intermediate b10.0

Graphical network of the top 20 diseases related to Axonal Neuropathy:



Diseases related to axonal neuropathy

Symptoms for Axonal Neuropathy

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Drugs & Therapeutics for Axonal Neuropathy

About this section

Drugs for Axonal Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Nitric OxidePhase 358510102-43-9145068
Synonyms:
(.)NO
(NO)(.)
10102-43-9
14332-28-6
295566_ALDRICH
51005-20-0
51005-21-1
53851-19-7
90452-29-2
AC1L1ADQ
AC1L3QHF
AC1Q6QZ0
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
C00533
CCRIS 4319
CHEMBL1200689
CHEMBL1234765
CID145068
CID945
D00074
D009569
DB00435
EDRF
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
INOmax (TN)
LS-192158
LS-7547
MolPort-003-929-452
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Monoxido de nitrogeno
Monoxyde d'azote
NITRIC-OXIDE
NO
NO(.)
Nitrate Vasodilator, Endogenous
Nitric Oxide, Endothelium Derived
 
Nitric Oxide, Endothelium-Derived
Nitric oxide
Nitric oxide (JAN)
Nitric oxide 10% by volume or more
Nitric oxide trimer
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
Nitrogen protoxide
Nitrosyl
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitrosyl radical
Nitroxide radical
Nitroxyl
OHM 11771
Oxide, Nitric
Oxido de nitrogeno(ii)
Oxido nitrico
Oxyde azotique
Oxyde nitrique
Oxyde nitrique [French]
RCRA waste no. P076
Stickmonoxyd
Stickmonoxyd [German]
Stickstoff(II)-oxid
Stickstoff(ii)-oxid
Stickstoffmonoxid
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
[NO]
endothelium-derived relaxing factor
monoxido de nitrogeno
monoxyde d'azote
nitric oxide
nitrogen monooxide
nitrogen monoxide
nitrosyl
oxido de nitrogeno(II)
oxido nitrico
oxidonitrogen(.)
oxoazanyl
oxyde azotique
2
AcetylcysteinePhase 2304616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
3TocotrienolNutraceuticalPhase 2391
4
vitamin eNutraceuticalPhase 239259-02-914985
Synonyms:
(+)-a-Tocopherol
(+)-alpha-Tocopherol
(+)-α-tocopherol
(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL
(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol
(2R,4'R,8'R)-a-Tocopherol
(2R,4'R,8'R)-alpha-Tocopherol
(2R,4'R,8'R)-α-tocopherol
(R,R,R)-a-Tocopherol
(R,R,R)-alpha-Tocopherol
(R,R,R)-α-tocopherol
5,7,8-Trimethyltocol
5,7,8-trimethyltocol
Amino-Opti-E
Aquasol E
D-alpha-Tocopherol
Daltose
Denamone
E-200 I.U. Softgels
 
E-Complex-600
E-Ferol
E-Vitamin succinate
Eprolin
Gordo-Vite E
Phytogermin
Phytogermine
RRR-alpha-tocopherol
RRR-alpha-tocopheryl
Tocopherol
Vitamin E
Vitamin Ea
Vitamin Plus E Softgells
Vitec
a-D-Tocopherol
a-Tocopherol
alpha-Tocopherol
alpha-delta-Tocopherol
alpha-tocopherol
d-α-tocopherol
delta-alpha-Tocopherol
5TocopherolNutraceuticalPhase 2395
6
Folic AcidNutraceuticalPhase 2414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
7FolateNutraceuticalPhase 24143
8
flupirtinePhase 1356995-20-153276
Synonyms:
 
Flupirtine
9
ChlormezanonePhase 1280-77-32717
Synonyms:
(+-)-Chlormezanone
(+-)-Fenarol
(±)-chlormezanone
102818-65-5
2-(4-Chlorophenyl)-3-methyl-1,3-thiazinan-4-one 1,1-dioxide
2-(4-Chlorophenyl)-3-methyl-4-metathiazanone-1,1-dioxide
2-(4-Chlorophenyl)tetrahydro-3-methyl-4H,1,3-thiazin-4-one 1,1-Dioxide
2-(4-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
2-(4-Chlorphenyl)-3-methyl-4-metathiazanon-1,1-dioxid
2-(4-chlorophenyl)-3-methyl-1,1-dioxo-1,3-thiazinan-4-one
2-(P-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
2-(P-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
2-(p-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
2-(p-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
2-(para-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one, 1,1-dioxide
4H-1,3-Thiazin-4-one, 2-(4-chlorophenyl)tetrahydro-3-methyl-, 1,1-dioxide
4H-1,3-Thiazin-4-one, 2-(4-chlorophenyl)tetrahydro-3-methyl-1,1-dioxide
4H-1,3-Thiazin-4-one, 2-(p-chlorophenyl)tetrahydro-3-methyl-, 1,1,-dioxide
4H-1,3-Thiazin-4-one, 2-(p-chlorophenyl)tetrahydro-3-methyl-, 1,1-dioxide
4H-1,3-Thiazin-4-one, 2-(p-chlorophenyl)tetrahydro-3-methyl-1,1-dioxide
4H-1,3-Thiazin-4-one, tetrahydro-2-(p-chlorophenyl)-3-methyl-, 1,1-dioxide
80-77-3
AB00052410
AC1L1EB2
AKOS000121464
Alinam
BPBio1_000409
BPBio1_001189
BRD-A20348246-001-05-9
BSPBio_000371
BSPBio_002728
Banabil-sintyal
Banabin
Banabin-sintyal
Banabin-syntyal
Biomol-NT_000277
Bisina
C-192
C11H12ClNO3S
CHEBI:3619
CHEMBL1200714
CID2717
Chlomedinon
Chlormethazanone
Chlormethazone
Chlormezanon
Chlormezanona
Chlormezanone
Chlormezanone (JAN/INN)
Chlormezanone [BAN:INN:JAN]
Chlormezanone [INN:BAN:JAN]
Chlormezanonum
Chlormezanonum [INN-Latin]
Clorilax
Clormetazanone
Clormetazon
Clormezanona
Clormezanona [INN-Spanish]
Clormezanone
Clormezanone [DCIT]
D00268
DB01178
Dichloromethazanone
Dichloromezanone
DivK1c_000886
Dl-Chlormezanone
EINECS 201-307-4
EU-0100383
 
HMS1569C13
HMS502M08
HSDB 3300
I01-1903
IDI1_000886
InChI=1/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
KBio1_000886
KBio2_000894
KBio2_003462
KBio2_006030
KBio3_001948
KBioGR_001734
KBioSS_000894
LS-150535
Lobak
Lopac0_000383
Mio-sed
Miorilax
MolPort-003-666-762
Muskel
Muskel-Trancopal
Myolespen
NCGC00015191-03
NCGC00015191-08
NCGC00024597-02
NCGC00024597-03
NCGC00024597-04
NCGC00024597-05
NINDS_000886
NSC 169108
NSC169108
Oprea1_275911
Phenarol
Prestwick0_000336
Prestwick1_000336
Prestwick2_000336
Prestwick3_000336
Prestwick_736
Rexan
Rilansyl
Rilaquil
Rilasol
Rilassol
Rilax
Rillasol
S2021_Selleck
SPBio_001793
SPBio_002292
SPECTRUM2300062
Spectrum2_001807
Spectrum3_001084
Spectrum4_001237
Spectrum5_001364
Spectrum_000414
Supotran
Suprotan
T5889171
TRANCOPAL (TN)
Tanafol
Trancopal
Trancote
Tranrilax
Transanate
UNII-GP568V9G19
WIN 4692
WLN: T6VN DSWTJ B1 CR DG
chlormezanona
chlormezanone
dl-Chlormezanone
10
Capsaicin163404-86-41548943
Synonyms:
(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
(6E)-N-{[4-hydroxy-3-(methyloxy)phenyl]methyl}-8-methylnon-6-enamide
(E)-8-Methyl-N-vanillyl-6-nonenamide
(E)-8-Methyl-N-vanillyl-6-nonenamide(8cl)
(E)-Capsaicin
(E)-N-((4-Hydroxy-3-methoxyphenyl)-methyl)-8-methyl-6-nonenamide
(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide
(E)8-methyl-N-vanillyl-6-Nonenamide
12084_FLUKA
21748_FLUKA
21748_SIGMA
21750_FLUKA
21750_SIGMA
360376_ALDRICH
360376_SIGMA
404-86-4
6-Nonenamide, (E)-N-((4-hydroxy-3-methoxy-phenyl)methyl)-8-methyl
6-Nonenamide, 8-methyl-N-vanillyl-, (E)- (8CI)
8 Methyl N Vanillyl 6 Nonenamide
8-Methyl-N-Vanillyl-6-Nonenamide
8-Methyl-N-vanillyl-trans-6-nonenamide
912457-62-6
AC1LU7K3
AC1Q46B3
Alacan Brand of Capsaicin
Antiphlogistine Rub A-535 Capsaicin
Axsain
BPBio1_001053
BRD-K37056290-001-01-1
BRD-K50590187-001-06-6
BRN 2816484
BSPBio_000957
BSPBio_001548
BSPBio_002917
Bio-0615
C-1700
C06866
C18H27NO3
CAPSAICIN (2444-46-4 NONIVAMIDE (SYNTHETIC CAPSAICIN))
CAPSAICINE
CCRIS 1588
CHEBI:3374
CHEMBL294199
CID1548943
Capsaicin
Capsaicin (JAN/USP)
Capsaicin (Natural)
Capsaicin (in oleoresin of capsicum)
Capsaicin (jan/usp)
Capsaicin Patch
Capsaicin [USAN]
Capsaicin [in oleoresin of capsicum]
Capsaicin [usan]
Capsicum Farmaya
Capsidol
Capsin
Capzasin
Carter Horner Brand of Capsaicin
Caswell No. 158
Centrum Brand of Capsaicin
D002211
D00250
E-CAPSAICIN
E-Capsaicin
EINECS 206-969-8
EPA Pesticide Chemical Code 070701
Elan Brand of Capsaicin
FEMA No. 3404
FT-0082538
Flemming Brand of Capsaicin
Gelcen
HMS1361N10
HMS1570P19
HMS1791N10
HMS1921H11
HMS1989N10
 
HMS2089N11
HMS2092D21
HMS501B16
HSDB 954
I01-2469
IDI1_000354
IDI1_034018
Isodecenoate
Isodecenoic acid
Isodecenoic acid vanillylamide
Katrum
LS-2138
Link Brand of Capsaicin
M1149
M2028_SIGMA
MEGxp0_001448
MLS002154049
MR3H3
Medicis Brand of Capsaicin
MolPort-001-742-263
N-(4-Hydroxy-3-methoxybenzyl)-8-methylnon-trans-6-enamide
N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide
NCGC00090853-01
NCGC00090853-02
NCGC00090853-03
NCGC00090853-04
NCGC00090853-06
NCGC00090853-07
NCGC00090853-08
NCGC00090853-09
NCI-C56564
NGX 4010
NGX-1998
NGX-3781
NGX-4010
NGX-7325
NGX4010
NSC 56353
NSC56353
Prestwick2_000879
Prestwick3_000879
Prestwick_204
Qutenza
S1990_Selleck
SDCCGMLS-0066678.P001
SMP2_000337
SMR000718774
SPECTRUM1501128
Smaller Brand of Capsaicin
Spectrum5_000538
Styptysat
TL8002946
TQ-1018
Thompson Brand of Capsaicin
Transacin
UNII-S07O44R1ZM
UPCMLD-DP092
UPCMLD-DP092:001
UPCMLD-DP092:002
Vinas Brand of Capsaicin
ZINC01530575
ZOSTRIX (TN)
Zacin
Zostrix
Zostrix (TN)
Zostrix HP
[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
depletes Substance P
epsilon-Capsaicin
n-(4-hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide
nchembio.146-comp1
nchembio862-comp2
neurotoxic
trans-8-Methyl-N-vanillyl-6-nonenamide
trans-Capsaicin

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Near Infrared Light for the Treatment of Painful Peripheral NeuropathyTerminatedNCT00125268Phase 3
2A Clinical Trial for AMN: Validation of Biomarkers of Oxidative Stress, Efficacy and Safety of a Mixture of AntioxidantsCompletedNCT01495260Phase 2
3Effect of the Kv7-channel Opener Flupirtine on the Excitability of Human Peripheral Myelinated Axons in VivoCompletedNCT01450865Phase 1
4Intrathecal Administration of scAAV9/JeT-GAN for the Treatment of Giant Axonal NeuropathyRecruitingNCT02362438Phase 1
5The Significance of Glucose Intolerance in the Pathogenesis of Idiopathic Axonal PolyneuropathyTerminatedNCT00228345Phase 1
6Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT01793168
7Magnetic Resonance Diagnostics of Diabetic Peripheral NeuropathyRecruitingNCT01847937
8Use of QTRAC Technique to Measure Axonal Excitability in Anti-MAG NeuropathyRecruitingNCT02468596
9CHRONIC OPTIC NEUROPATHY IN MULTIPLE SCLEROSISRecruitingNCT02543788
10Giant Axonal Neuropathy Natural History StudyActive, not recruitingNCT01503125
11The Effect of Bariatric Surgery on Peripheral Nerve Function and Axonal RegenerationActive, not recruitingNCT02218866
12Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1ANot yet recruitingNCT01750710
13Exploratory Study of Predictive Markers of the Therapeutic Response in Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy Treated With Intravenous ImmunoglobulinNot yet recruitingNCT02892890

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Genetic Tests for Axonal Neuropathy

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Anatomical Context for Axonal Neuropathy

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MalaCards organs/tissues related to Axonal Neuropathy:

34
Skin, Brain, Testes, Globus pallidus, Tongue, Endothelial, T cells

Animal Models for Axonal Neuropathy or affiliated genes

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MGI Mouse Phenotypes related to Axonal Neuropathy:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.4GAN, GARS, LMNA, MFN2, PMP22, POLG
2MP:00053847.1C10orf2, GAN, GDAP1, HINT1, KIF5A, LMNA
3MP:00053866.9ATL1, GAN, GARS, GDAP1, KIF5A, LMNA
4MP:00036316.5GAN, GARS, GDAP1, KIF5A, LMNA, MFN2

Publications for Axonal Neuropathy

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Articles related to Axonal Neuropathy:

(show top 50)    (show all 353)
idTitleAuthorsYear
1
A Novel Variant in the HINT1 Gene in a Girl with Autosomal Recessive Axonal Neuropathy with Neuromyotonia: Thorough Neurological Examination Gives the Clue. (26760849)
2016
2
Abnormal intermediate filament organization alters mitochondrial motility in giant axonal neuropathy fibroblasts. (26700320)
2016
3
Giant axonal neuropathy-like disease in an Alexandrine parrot (Psittacula eupatria). (26330398)
2015
4
Elevated blood mercury levels in idiopathic axonal neuropathy. (25867721)
2015
5
Temporary conduction block in acute motor axonal neuropathy. (26442689)
2015
6
Compound muscle action potential amplitude and distal potential duration in axonal neuropathy. (24038120)
2014
7
De novo Mutations in the Motor Domain of KIF1A Cause Cognitive Impairment, Spastic Paraparesis, Axonal Neuropathy and Cerebellar Atrophy. (25265257)
2014
8
Giant axonal neuropathy: An updated perspective on its pathology and pathogenesis. (24947478)
2014
9
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy. (25008398)
2014
10
Axonal neuropathy in female carriers of the fragile X premutation with fragile X-associated tremor ataxia syndrome. (25388402)
2014
11
A case of acute motor and sensory axonal neuropathy following hepatitis a infection. (24339719)
2013
12
Heterogeneity of axonal pathology in Chinese patients with giant axonal neuropathy. (24273072)
2013
13
Explaining intermediate filament accumulation in giant axonal neuropathy. (25003002)
2013
14
Motor Axonal Neuropathy Associated With Idiopathic CD4(+) T-Lymphocytopenia. (23526179)
2013
15
Clinicogenetical features of a Japanese patient with giant axonal neuropathy. (21356581)
2012
16
Acute transverse myelitis and acute motor axonal neuropathy developed after vaccinations against seasonal and 2009 A/H1N1 influenza. (21372468)
2011
17
Giant axonal neuropathy caused by compound heterozygosity for a maternally inherited microdeletion and a paternal mutation within the GAN gene. (20949505)
2010
18
Spectrum of magnetic resonance imaging findings in a family with giant axonal neuropathy confirmed by genetic studies. (19439850)
2009
19
Clinical features and molecular modelling of novel MPZ mutations in demyelinating and axonal neuropathies. (19293842)
2009
20
Clinical and genetic studies in a Chinese family with giant axonal neuropathy. (19295179)
2009
21
Clinical, pathological and molecular findings in two siblings with giant axonal neuropathy (GAN): report from India. (18595793)
2008
22
Acute motor axonal neuropathy presenting with bowel, bladder, and erectile dysfunction. (17334958)
2007
23
Alterations in lipid metabolism gene expression and abnormal lipid accumulation in fibroblast explants from giant axonal neuropathy patients. (17331252)
2007
24
Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect. (16374829)
2006
25
Cerebellar ataxia and acute motor axonal neuropathy associated with Anti GD1b and Anti GM1 antibodies. (16054817)
2005
26
An unusual phenotype of McLeod syndrome with late onset axonal neuropathy. (14638894)
2003
27
Acute motor axonal neuropathy with selective involvement of the lower limbs. (19078684)
2002
28
Axonal neuropathy in chronic peripheral arterial occlusive disease. (12362411)
2002
29
Infantile neuroaxonal dystrophy and giant axonal neuropathy--overlap diseases of neuronal cytoskeletal elements in childhood? (11048747)
2000
30
Age related axonal neuropathy in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). (10071104)
1999
31
Hyperreflexia in Guillain-BarrAc syndrome: relation with acute motor axonal neuropathy and anti-GM1 antibody. (10406985)
1999
32
Axonal neuropathy and predominance of type II myofibers in infantile spinal muscular atrophy. (9701481)
1998
33
Lissencephaly associated with congenital hypomyelinating and axonal neuropathy. (9831005)
1998
34
Chronic relapsing axonal neuropathy responsive to intravenous immunoglobulin. (9596031)
1998
35
Congenital axonal neuropathy caused by deletions in the spinal muscular atrophy region. (9307259)
1997
36
Giant axonal neuropathy: a generalized disorder of intermediate filaments with longitudinal grooves in the hair. (8072681)
1994
37
Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. (8489203)
1993
38
Giant axonal neuropathy with predominant central nervous system manifestations. (1310292)
1992
39
Anaesthesia for a patient with giant axonal neuropathy. (2048666)
1991
40
Multiple sclerosis associated with axonal neuropathy. (2100156)
1990
41
Giant axonal neuropathy with inherited multisystem degeneration in a Tunisian kindred. (2153943)
1990
42
Abnormalities of sympathetic vasomotor tone in distal axonal neuropathy. (2544682)
1989
43
Delayed onset of distal axonal neuropathy in primates after prolonged low-level administration of a neurotoxin. (2817831)
1989
44
Characterization of the intermediate filament apparatus in skin fibroblasts from patients with giant axonal neuropathy: effect of trypsin. (3308126)
1987
45
Congenital giant axonal neuropathy. (2990373)
1985
46
Giant axonal neuropathy. Endocrinological and histological studies. (4054168)
1985
47
Canine giant axonal neuropathy; some aspects of its clinical, pathological and comparative features. (7031366)
1981
48
The central nervous system in canine giant axonal neuropathy. (223361)
1979
49
Generalized giant axonal neuropathy: a filament-forming disease of neuronal, endothelial, glial, and schwann cells in a patient without kinky hair. (602684)
1977
50
Giant axonal neuropathy--a unique case with segmental neurofilamentous masses. (5044004)
1972

Variations for Axonal Neuropathy

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Expression for genes affiliated with Axonal Neuropathy

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Search GEO for disease gene expression data for Axonal Neuropathy.

Pathways for genes affiliated with Axonal Neuropathy

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GO Terms for genes affiliated with Axonal Neuropathy

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Cellular components related to Axonal Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrionGO:00057397.2C10orf2, C12orf65, C19orf12, GARS, GDAP1, MFN2

Biological processes related to Axonal Neuropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial fusionGO:000805310.3GDAP1, MFN2
2mitochondrial DNA replicationGO:00062649.7C10orf2, POLG
3protein ubiquitinationGO:00165679.2DCAF8, GAN, MIR4720, TRIM2

Sources for Axonal Neuropathy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet