MCID: AZS001
MIFTS: 44

Azoospermia malady

Summaries for Azoospermia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards: Azoospermia is related to infertility and oligospermia. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord.

Description from OMIM:46 415000

Aliases & Classifications for Azoospermia

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM
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Aliases & Descriptions:

azoospermia 8 22 10 44 60


External Ids:

Disease Ontology8 DOID:14227
ICD9CM27 606.0
MeSH34 D053713
OMIM46 415000

Related Diseases for Azoospermia

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17GeneCards, 18GeneDecks
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Diseases in the Azoospermia family:

Azoospermia Due to Perturbations of Meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.2DAZ2, DAZ1, DAZ4, DAZL, SYCP3, SOHLH1
2oligospermia30.9DAZ1, DAZ2
3male infertility30.8AZF1, RBMY1A1, DAZL, DAZ4, DAZ1, BOLL
4y chromosome infertility30.4DAZ1, RBMY1A1, HSFY1
5sertoli cell-only syndrome30.4DAZ2, DAZ1
6cryptorchidism30.3DAZ1, AZF1
7varicocele10.5
8cystic fibrosis10.3
9young syndrome10.3
10hypogonadism10.2
11testicular cancer10.2
12spermatogenic failure 410.2
13azoospermia due to perturbations of meiosis10.1
14klinefelter's syndrome10.0
15intussusception10.0
16situs inversus10.0
17spermatocele10.0
18hypogonadotropism10.0
19sarcoidosis10.0
20smith magenis syndrome10.0AZF1, RBMY1A1, DAZL, DAZ1
21turner syndrome10.0RBMY1F, RBMY1J
22gonadoblastoma10.0RBMY1F, RBMY1J
23graft versus host disease9.9
24ureteral obstruction9.9
25tuberculous epididymitis9.9
26acute pancreatitis9.9
27machado-joseph disease9.9
28bronchiolitis9.9
29cystadenoma9.9
30williams-beuren syndrome9.9
31arteriovenous malformation9.9
32hyperprolactinemia9.9
33sertoli cell tumor9.9
34panhypopituitarism9.9
35radioulnar synostosis9.9
36congenital adrenal hyperplasia9.9
37oculocerebrorenal syndrome9.9
38cystinosis9.9
39primary ciliary dyskinesia9.9
40hypospadias9.9
41fabry disease9.9
42pantothenate kinase-associated neurodegeneration9.9
43chromosomal disease9.9
44conjunctivitis9.9
45hodgkin's lymphoma9.9
46hydrocele9.9
47impotence9.9
48myotonic disease9.9
49myotonic dystrophy9.9
50obesity9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Clinical Features for Azoospermia

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46OMIM
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Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Azoospermia

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Search CenterWatch for Azoospermia

Genetic Tests for Azoospermia

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22GTR
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Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

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32MalaCards
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MalaCards organs/tissues related to Azoospermia:

32
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

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Publications for Azoospermia

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Sources:
50PubMed
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Articles related to Azoospermia:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Pathogenic variants screening in five non-obstructive azoospermia-associated genes. (24162948)
2014
2
Pregnancy outcome after ICSI with thawed testicular sperm from men with non-obstructive azoospermia compared to ICSI with ejaculated sperm from men with severe oligoasthenoteratozoospermia and IVF with normal ejaculated sperm. (24303883)
2014
3
Outcome of intracytoplasmic sperm injection cycles with fresh testicular spermatozoa obtained on the day of or the day before oocyte collection and with cryopreserved testicular sperm in patients with azoospermia. (23891272)
2013
4
Study of the prevalence of azoospermia in patients with Hodgkin's lymphoma prior to treatment. (24223388)
2013
5
A comparison of models for predicting sperm retrieval before microdissection testicular sperm extraction in men with nonobstructive azoospermia. (23260551)
2013
6
Regeneration of spermatogenesis in a mouse model of azoospermia by follicle-stimulating hormone and oestradiol. (24325627)
2013
7
Exceptional complex chromosomal rearrangement and microdeletions at the 4q22.3q23 and 14q31.1q31.3 regions in a patient with azoospermia. (23031811)
2013
8
Reproductive outcomes, including neonatal data, following sperm injection in men with obstructive and nonobstructive azoospermia: case series and systematic review. (23503964)
2013
9
Reproductive potential of men with obstructive azoospermia undergoing percutaneous sperm retrieval and intracytoplasmic sperm injection according to the cause of obstruction. (23174251)
2013
10
The PGAM4 gene in non-obstructive azoospermia. (23631659)
2013
11
Impact of fresh versus cryopreserved testicular sperm upon intracytoplasmic sperm injection pregnancy outcomes in men with azoospermia due to spermatogenic dysfunction: a meta-analysis. (24345355)
2013
12
Clinical characteristics and treatment of azoospermia and severe oligospermia patients with Y-chromosome microdeletions. (24002933)
2013
13
Patency rates of microsurgical vasoepididymostomy for patients with idiopathic obstructive azoospermia: a prospective analysis of factors associated with patency--single-center experience. (22202547)
2012
14
Re: heat shock factor Y chromosome (HSFY) mRNA level predicts the presence of retrievable testicular sperm in men with nonobstructive azoospermia. (22237366)
2012
15
Chromosomal and molecular abnormalities in a group of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia attending an infertility service. (21557841)
2011
16
Techniques for microsurgical reconstruction of obstructive azoospermia. (21716572)
2011
17
Obstructive azoospermia as an unusual complication associated with herniorrhaphy of an omphalocele: a case report. (21702973)
2011
18
Expression of NOSTRIN in the testis tissue of azoospermia patients]. (21351530)
2011
19
Alternate indications for varicocele repair: non-obstructive azoospermia, pain, androgen deficiency and progressive testicular dysfunction. (22130099)
2011
20
Prevalent false positives of azoospermia factor a (AZFa) microdeletions caused by single-nucleotide polymorphism rs72609647 in the sY84 screening of male infertility. (21765443)
2011
21
The effect of prior varicocelectomy in patients with nonobstructive azoospermia on intracytoplasmic sperm injection outcomes: a retrospective pilot study. (19913887)
2010
22
Testis transcriptome analysis in male infertility: new insight on the pathogenesis of oligo-azoospermia in cases with and without AZFc microdeletion. (20576090)
2010
23
Controversies in the management of nonobstructive azoospermia. (19304289)
2009
24
Clinical observation of loupe-assisted intussusception vasoepididymostomy in the treatment of obstructive azoospermia (analysis of 49 case reports). (19219057)
2009
25
Single-nucleotide polymorphisms of the PRDM9 (MEISETZ) gene in patients with nonobstructive azoospermia. (19168450)
2009
26
High serum FSH levels in men with nonobstructive azoospermia does not affect success of microdissection testicular sperm extraction. (18973887)
2009
27
Efficacy of percutaneous needle aspiration and open biopsy for sperm retrieval in men with non-obstructive azoospermia. (18850334)
2008
28
Acute renal failure may lead to reversible azoospermia. (18279857)
2008
29
Which is the best sperm retrieval technique for non-obstructive azoospermia? A systematic review. (17895238)
2007
30
The analysis of CFTR mutations in men with azoospermia, oligozoospermia and asthenozoospermia]. (18050608)
2007
31
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. (16372124)
2006
32
Azoospermia: virtual reality or possible to quantify? (16598028)
2006
33
Early successful orchidopexy does not prevent from developing azoospermia. (17081328)
2006
34
Defective expression of Galpha12 in the testes of azoospermia patients and in the spermatozoa with low motility. (16612612)
2006
35
Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. (16595237)
2006
36
Scrotal US for evaluation of infertile men with azoospermia. (16467212)
2006
37
Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype. (16192717)
2005
38
Secondary azoospermia after vasovasostomy. (15882733)
2005
39
A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia. (15734897)
2005
40
Yq microdeletions--azoospermia factor candidate genes and spermatogenic arrest. (15331583)
2004
41
Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) in hypogonadotropic hypogonadism with persistent azoospermia after hormonal therapy. (15202738)
2004
42
Should diagnostic testicular sperm retrieval followed by cryopreservation for later ICSI be the procedure of choice for all patients with non-obstructive azoospermia? (15492024)
2004
43
Re: testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. (15126855)
2004
44
Morphological and morphometric attributes of epididymal and testicular spermatozoa following surgical sperm retrieval for obstructive and nonobstructive azoospermia. (15018138)
2003
45
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. (11994405)
2002
46
A nation-based population screening for azoospermia factor deletions in Greek-Cypriot patients with severe spermatogenic failure and normal fertile controls, using a specific study and experimental design. (12031043)
2002
47
Possible relationship between seminal plasma inhibin B and spermatogenesis in patients with azoospermia. (12399529)
2002
48
Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. (12185095)
2002
49
Y-chromosome microdeletion and its effect on reproductive decisions in taiwanese patients presenting with nonobstructive azoospermia. (11113757)
2000
50
Incidence of AZF (azoospermia factor) deletions and familial forms of infertility among patients requiring intracytoplasmic spermatozoa injection (ICSI). (9447460)
1997

Genetic Variations for Azoospermia

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Expression for genes affiliated with Azoospermia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Azoospermia

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Pathways for genes affiliated with Azoospermia

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Compounds for genes affiliated with Azoospermia

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GO Terms for genes affiliated with Azoospermia

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16Gene Ontology
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Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3DAZAP2, HSFY2, SOHLH1, MEF2D, RBMY1D, RBMY1J
2cytoplasmGO:00573711.2SOHLH1, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.3RBMY1B, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3
2cell differentiationGO:03015411.0DAZ2, DAZ3, DAZ1, DAZ4, DAZAP1, SOHLH1
3RNA splicingGO:00838010.8RBMY1J, RBMY1A1, RBMY1B, RBMY1E, RBMY1D
4mRNA processingGO:00639710.7RBMY1B, RBMY1A1, RBMY1J, RBMY1D, RBMY1E
5positive regulation of translational initiationGO:04594810.7BOLL, DAZ1, DAZL
6multicellular organismal developmentGO:00727510.6DAZ1, DAZL, BOLL, DAZ2, DAZ3, DAZ4

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00016611.2BOLL, RBMY1D, RBMY1J, RBMY1A1, RBMY1B, RBMY1E
2RNA bindingGO:00372310.9RBMY1E, RBMY1B, RBMY1J, RBMY1D, DAZAP1, DAZL
3translation activator activityGO:00849410.7BOLL, DAZ1, DAZL

Products for genes affiliated with Azoospermia

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Sources for Azoospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet