MCID: AZS001
MIFTS: 45

Azoospermia malady

Genetic diseases (common), Reproductive diseases categories
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Summaries for Azoospermia

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Wikipedia:65 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards based summary: Azoospermia is related to oligospermia and sertoli cell-only syndrome. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Description from OMIM:46 415000

Aliases & Classifications for Azoospermia

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 27ICD9CM, 46OMIM, 34MeSH
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Azoospermia, Aliases & Descriptions:

Name: Azoospermia 8 22 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:14227
ICD9CM27 606.0
OMIM46 415000
MeSH34 D053713

Related Diseases for Azoospermia

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Diseases in the Azoospermia family:

Azoospermia Due to Perturbations of Meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1oligospermia31.3DAZ2, DAZ1
2sertoli cell-only syndrome30.7DAZ1, DAZ2
3cryptorchidism30.5AZF1, DAZ1
4male infertility30.5DAZL, DAZ3, HSFY1
5infertility30.5AZF1, SYCP3, DAZL, DAZ1, DAZ4, DAZ2
6y chromosome infertility30.4RBMY1A1, HSFY1, DAZ1
7klinefelter's syndrome30.3DAZ4, AZF1
8epididymitis10.5
9varicocele10.5
10cystic fibrosis10.3
11young syndrome10.3
12spermatogenic failure10.3
13hypogonadism10.2
14azoospermia due to perturbations of meiosis10.2
15spermatogenic failure 410.2
16intussusception10.2
17spinal cord injury10.1
18situs inversus10.1
19spermatocele10.1
20conjunctivitis10.1
21sarcoidosis10.1
22hypoxia10.1
23spinocerebellar ataxia 3210.1
24smith magenis syndrome9.9DAZL, DAZ1, AZF1, RBMY1A1
25graft versus host disease9.9
26hematopoietic stem cell transplantation9.9
27hodgkin's lymphoma9.9
28obesity9.9
29primary ciliary dyskinesia9.9
30wilms tumor9.9
31cystadenoma9.9
32bronchiolitis9.9
33acute pancreatitis9.9
34hypogonadotropism9.9
35fabry disease9.9
36williams-beuren syndrome9.9
37machado-joseph disease9.9
38tuberculous epididymitis9.9
39oculocerebrorenal syndrome9.9
40cystinosis9.9
41panhypopituitarism9.9
42radioulnar synostosis9.9
43myotonic dystrophy type 19.9
44hyperprolactinemia9.9
45hypospadias9.9
46arteriovenous malformation9.9
47pantothenate kinase-associated neurodegeneration9.9
48hydrocele9.9
49impotence9.9
50pancreatitis9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Symptoms for Azoospermia

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Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

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Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Genetic Tests for Azoospermia

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Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

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MalaCards organs/tissues related to Azoospermia:

32
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

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MGI Mouse Phenotypes related to Azoospermia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8DAZAP1, SOHLH1, SYCP3, BOLL, DAZL
2MP:00053798.5BOLL, SYCP3, SOHLH1, DAZAP1, DAZL

Publications for Azoospermia

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Articles related to Azoospermia:

(show top 50)    (show all 635)
idTitleAuthorsYear
1
rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia. (23993922)
2013
2
Non-chimerism and chimerism pseudo dicentric Y chromosome: two case reports about azoospermia and cytogenetic/molecular genetic analysis in the Chinese population. (23504399)
2013
3
Outcome of intracytoplasmic sperm injection cycles with fresh testicular spermatozoa obtained on the day of or the day before oocyte collection and with cryopreserved testicular sperm in patients with azoospermia. (23891272)
2013
4
Different cystic fibrosis transmembrane conductance regulator mutations in Chinese men with congenital bilateral absence of vas deferens and other acquired obstructive azoospermia. (23953609)
2013
5
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. (23550190)
2013
6
The importance of semen analysis in the context of azoospermia. (23503953)
2013
7
Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. (23122830)
2013
8
Microdissection testicular sperm extraction (micro-TESE) as a sperm acquisition method for men with nonobstructive azoospermia seeking fertility: operative and laboratory aspects. (23849579)
2013
9
Medical management of non-obstructive azoospermia. (23503956)
2013
10
Midkine promotes proliferation of primordial germ cells by inhibiting the expression of the deleted in azoospermia-like gene. (22564978)
2012
11
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
12
The value of testicular 'mapping' in men with non-obstructive azoospermia. (21258355)
2011
13
High risk of azoospermia in men treated for childhood cancer. (20345878)
2011
14
Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count. (21429917)
2011
15
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
16
Long-term proliferation and characterization of human spermatogonial stem cells obtained from obstructive and non-obstructive azoospermia under exogenous feeder-free culture conditions. (20590666)
2010
17
Differential diagnosis of azoospermia and etiologic classification of obstructive azoospermia: role of scrotal and transrectal US. (20515977)
2010
18
Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study. (19731213)
2009
19
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
20
Rapidly progressing, late-onset obstructive azoospermia linked to herniorrhaphy with mesh. (18675969)
2008
21
Tag STS in the AZF region associated with azoospermia in a Tunisian population. (17409464)
2007
22
Semen evaluation for verification of azoospermia after vasectomy in chimpanzees (Pan troglodytes). (17877328)
2007
23
Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. (17172283)
2007
24
Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (16824523)
2006
25
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. (16372124)
2006
26
Azoospermia: virtual reality or possible to quantify? (16598028)
2006
27
Vasal obstruction after hernioplasty: the importance of surgical strategy in preventing azoospermia. (16794407)
2006
28
Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (16884537)
2006
29
Immunophenotypical characterization of contractile cells in caput epididymidis of men affected by congenital or post-inflammatory obstructive azoospermia. (15734898)
2005
30
Constitutional mosaic trisomy 21 and azoospermia: a case report. (15719052)
2005
31
Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype. (16192717)
2005
32
Sperm retrieval for intra-cytoplasmic sperm injection in non-obstructive azoospermia. (15951734)
2005
33
Meiotic studies of infertile men in case of non-obstructive azoospermia with normal karyotype and no microdeleted Y-chromosome precise the clinical couple management. (15183743)
2004
34
Outcome of testicular sperm recovery and ICSI in patients with non-obstructive azoospermia with a history of orchidopexy. (15310729)
2004
35
Yq microdeletions--azoospermia factor candidate genes and spermatogenic arrest. (15331583)
2004
36
New techniques for sperm acquisition in obstructive azoospermia. (15363724)
2004
37
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (15081113)
2004
38
Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. (12620433)
2003
39
Spermatogonial proliferation patterns in men with azoospermia of different etiologies. (14607570)
2003
40
Absence of microdeletions in the azoospermia-factor region of the Y-chromosome in Viennese men seeking assisted reproduction. (14740346)
2003
41
Percutaneous epididymal sperm aspiration (PESA) in men with obstructive azoospermia. (15745497)
2003
42
Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. (12042281)
2002
43
Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (12366783)
2002
44
Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. (11726576)
2001
45
Absence of deleted in azoospermia (DAZ) genes in spermatozoa of infertile men with somatic DAZ deletions. (11239526)
2001
46
Identification of mutation and polymorphic changes in the CFTR gene of patients with obstructive azoospermia]. (11247407)
2000
47
Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. (10376575)
1999
48
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
49
Cystic fibrosis mutation screening in CBAVD patients and men with obstructive azoospermia or severe oligozoospermia. (9620832)
1998
50
The azoospermia factor (AZF) of the human Y chromosome in Yq11: function and analysis in spermatogenesis. (8711205)
1995

Variations for Azoospermia

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Expression for genes affiliated with Azoospermia

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Expression patterns in normal tissues for genes affiliated with Azoospermia

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Pathways for genes affiliated with Azoospermia

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Compounds for genes affiliated with Azoospermia

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GO Terms for genes affiliated with Azoospermia

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Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3DAZAP2, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
2nucleusGO:0056345.3RBMY1A1, DAZL, DAZAP2, DAZ1, DAZ4, DAZ2

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of translational initiationGO:0459489.4BOLL, DAZ1, DAZL
2RNA splicingGO:0083808.5RBMY1A1, RBMY1E, RBMY1D
3multicellular organismal developmentGO:0072758.4DAZL, DAZ1, DAZ4, DAZ2, DAZ3, BOLL
4mRNA processingGO:0063978.2RBMY1D, RBMY1E, RBMY1A1
5cell differentiationGO:0301548.0DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3, SOHLH1
6spermatogenesisGO:0072837.8BOLL, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation activator activityGO:0084949.5BOLL, DAZ1, DAZL
2RNA bindingGO:0037236.3DAZL, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
3nucleotide bindingGO:0001665.9RBMY1A1, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Products for genes affiliated with Azoospermia

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Sources for Azoospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet