MCID: AZS001
MIFTS: 41

Azoospermia malady

Reproductive diseases category

Aliases & Classifications for Azoospermia

About this section

Azoospermia, Aliases & Descriptions:

Name: Azoospermia 9 11 43 22
Spermatogenic Failure, Susceptibility to 10
 
Infertility Due to Azoospermia 60
Spermatogenic Failure 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:14227
MeSH33 D053713
ICD9CM27 606.0

Summaries for Azoospermia

About this section


Wikipedia:63 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards based summary: Azoospermia, also known as spermatogenic failure, susceptibility to, is related to oligospermia and sertoli cell-only syndrome. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Disease Ontology:9 A male infertility disease characterized by the absence of any measurable level of sperm in semen.

Related Diseases for Azoospermia

About this section

Diseases related to Azoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idRelated DiseaseScoreTop Affiliating Genes
1oligospermia31.3DAZ2, DAZ1
2sertoli cell-only syndrome30.7DAZ1, DAZ2
3cryptorchidism30.5AZF1, DAZ1
4male infertility30.5DAZL, DAZ3, HSFY1
5infertility30.5DAZL, DAZ1, DAZ4, DAZ2, AZF1, SOHLH1
6y chromosome infertility30.4RBMY1A1, HSFY1, DAZ1
7klinefelter's syndrome30.3AZF1, DAZ4
8spermatogenic failure 910.6
9epididymitis10.5
10spermatogenic failure, y-linked, 110.5
11varicocele10.5
12spermatogenic failure 710.4
13spermatogenic failure 1010.4
14spermatogenic failure 1110.4
15spermatogenic failure 510.4
16spermatogenic failure 210.4
17spermatogenic failure 610.4
18spermatogenic failure, x-linked, 210.4
19morbid obesity and spermatogenic failure10.3
20cystic fibrosis10.3
21young syndrome10.3
22macrozoospermia10.2
23hypogonadism10.2
24spermatogenic failure 410.1
25intussusception10.1
26prostate cancer10.1
27blindness10.1
28spinocerebellar ataxia 3210.1
29spermatogenic failure, y-linked, 210.1
30congenital bilateral absence of vas deferens10.1
31spinal cord injury10.1
32situs inversus10.1
33spermatocele10.1
34hypogonadotropism10.1
35conjunctivitis10.1
36hypoxia10.1
37smith-magenis syndrome9.9DAZL, DAZ1, AZF1, RBMY1A1
38rheumatoid arthritis9.9
39leukoencephalopathy with dystonia and motor neuropathy9.9
40anemia, hypochromic microcytic, with iron overload 29.9
41hyperprolactinemia9.9
42spermatogenic failure 39.9
43williams-beuren syndrome9.9
44hypogonadotropic hypogonadism 16 with or without anosmia9.9
45spermatogenic failure 89.9
46spermatogenic failure 129.9
47machado-joseph disease9.9
48bloom syndrome9.9
49fanconi anemia, complementation group a9.9
50spermatogenic failure 149.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Symptoms for Azoospermia

About this section

Drugs & Therapeutics for Azoospermia

About this section

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Genetic Tests for Azoospermia

About this section

Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

About this section

MalaCards organs/tissues related to Azoospermia:

31
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

About this section

MGI Mouse Phenotypes related to Azoospermia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8DAZAP1, SOHLH1, SYCP3, BOLL, DAZL
2MP:00053798.5BOLL, SYCP3, SOHLH1, DAZAP1, DAZL

Publications for Azoospermia

About this section

Articles related to Azoospermia:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia. (25739334)
2015
2
Microhomology-mediated microduplication in the y chromosomal azoospermia factor a region in a male with mild asthenozoospermia. (25765000)
2014
3
rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia. (23993922)
2013
4
Non-chimerism and chimerism pseudo dicentric Y chromosome: two case reports about azoospermia and cytogenetic/molecular genetic analysis in the Chinese population. (23504399)
2013
5
Outcome of intracytoplasmic sperm injection cycles with fresh testicular spermatozoa obtained on the day of or the day before oocyte collection and with cryopreserved testicular sperm in patients with azoospermia. (23891272)
2013
6
Different cystic fibrosis transmembrane conductance regulator mutations in Chinese men with congenital bilateral absence of vas deferens and other acquired obstructive azoospermia. (23953609)
2013
7
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. (23550190)
2013
8
The importance of semen analysis in the context of azoospermia. (23503953)
2013
9
Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. (23122830)
2013
10
Microdissection testicular sperm extraction (micro-TESE) as a sperm acquisition method for men with nonobstructive azoospermia seeking fertility: operative and laboratory aspects. (23849579)
2013
11
Midkine promotes proliferation of primordial germ cells by inhibiting the expression of the deleted in azoospermia-like gene. (22564978)
2012
12
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
13
The value of testicular 'mapping' in men with non-obstructive azoospermia. (21258355)
2011
14
High risk of azoospermia in men treated for childhood cancer. (20345878)
2011
15
Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count. (21429917)
2011
16
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
17
Long-term proliferation and characterization of human spermatogonial stem cells obtained from obstructive and non-obstructive azoospermia under exogenous feeder-free culture conditions. (20590666)
2010
18
Differential diagnosis of azoospermia and etiologic classification of obstructive azoospermia: role of scrotal and transrectal US. (20515977)
2010
19
Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study. (19731213)
2009
20
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
21
Rapidly progressing, late-onset obstructive azoospermia linked to herniorrhaphy with mesh. (18675969)
2008
22
Tag STS in the AZF region associated with azoospermia in a Tunisian population. (17409464)
2007
23
Semen evaluation for verification of azoospermia after vasectomy in chimpanzees (Pan troglodytes). (17877328)
2007
24
Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. (17172283)
2007
25
Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (16824523)
2006
26
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. (16372124)
2006
27
Azoospermia: virtual reality or possible to quantify? (16598028)
2006
28
Vasal obstruction after hernioplasty: the importance of surgical strategy in preventing azoospermia. (16794407)
2006
29
Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (16884537)
2006
30
Immunophenotypical characterization of contractile cells in caput epididymidis of men affected by congenital or post-inflammatory obstructive azoospermia. (15734898)
2005
31
Constitutional mosaic trisomy 21 and azoospermia: a case report. (15719052)
2005
32
Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype. (16192717)
2005
33
Sperm retrieval for intra-cytoplasmic sperm injection in non-obstructive azoospermia. (15951734)
2005
34
Meiotic studies of infertile men in case of non-obstructive azoospermia with normal karyotype and no microdeleted Y-chromosome precise the clinical couple management. (15183743)
2004
35
Outcome of testicular sperm recovery and ICSI in patients with non-obstructive azoospermia with a history of orchidopexy. (15310729)
2004
36
Yq microdeletions--azoospermia factor candidate genes and spermatogenic arrest. (15331583)
2004
37
New techniques for sperm acquisition in obstructive azoospermia. (15363724)
2004
38
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (15081113)
2004
39
Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. (12620433)
2003
40
Spermatogonial proliferation patterns in men with azoospermia of different etiologies. (14607570)
2003
41
Absence of microdeletions in the azoospermia-factor region of the Y-chromosome in Viennese men seeking assisted reproduction. (14740346)
2003
42
Percutaneous epididymal sperm aspiration (PESA) in men with obstructive azoospermia. (15745497)
2003
43
Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. (12042281)
2002
44
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. (11994405)
2002
45
Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (12366783)
2002
46
Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. (11726576)
2001
47
Absence of deleted in azoospermia (DAZ) genes in spermatozoa of infertile men with somatic DAZ deletions. (11239526)
2001
48
Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. (10376575)
1999
49
Cystic fibrosis mutation screening in CBAVD patients and men with obstructive azoospermia or severe oligozoospermia. (9620832)
1998
50
The azoospermia factor (AZF) of the human Y chromosome in Yq11: function and analysis in spermatogenesis. (8711205)
1995

Variations for Azoospermia

About this section

Expression for genes affiliated with Azoospermia

About this section
Search GEO for disease gene expression data for Azoospermia.

Pathways for genes affiliated with Azoospermia

About this section

Compounds for genes affiliated with Azoospermia

About this section

GO Terms for genes affiliated with Azoospermia

About this section

Cellular components related to Azoospermia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00057377.3DAZAP2, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
2nucleusGO:00056345.3RBMY1A1, DAZL, DAZAP2, DAZ1, DAZ4, DAZ2

Biological processes related to Azoospermia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of translational initiationGO:00459489.4BOLL, DAZ1, DAZL
2RNA splicingGO:00083808.5RBMY1A1, RBMY1E, RBMY1D
3multicellular organismal developmentGO:00072758.4DAZL, DAZ1, DAZ4, DAZ2, DAZ3, BOLL
4mRNA processingGO:00063978.2RBMY1D, RBMY1E, RBMY1A1
5cell differentiationGO:00301548.0DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3, SOHLH1
6spermatogenesisGO:00072837.8BOLL, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Molecular functions related to Azoospermia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1translation activator activityGO:00084949.5BOLL, DAZ1, DAZL
2RNA bindingGO:00037236.3DAZL, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
3nucleotide bindingGO:00001665.9RBMY1A1, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Products for genes affiliated with Azoospermia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Azoospermia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet