MCID: AZS001
MIFTS: 44

Azoospermia malady

Summaries for Azoospermia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards: Azoospermia is related to oligospermia and infertility. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include spinal cord, brain and kidney.

Description from OMIM:47 415000

Aliases & Classifications for Azoospermia

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 47OMIM
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Aliases & Descriptions:

azoospermia 8 22 10 45 61


External Ids:

Disease Ontology8 DOID:14227
ICD9CM27 606.0
MeSH35 D053713
OMIM47 415000

Related Diseases for Azoospermia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Azoospermia family:

azoospermia due to perturbations of meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1oligospermia30.9DAZ1, DAZ2
2infertility30.9DAZ2, DAZ1, DAZ4, DAZL, SYCP3, SOHLH1
3y chromosome infertility30.4DAZ1, RBMY1A1, HSFY1
4cryptorchidism30.3DAZ1, AZF1
5sertoli cell-only syndrome30.0DAZ2, DAZ1
6varicocele10.6
7cystic fibrosis10.3
8young syndrome10.3
9klinefelter's syndrome10.2
10n syndrome10.2
11testicular cancer10.2
12spermatogenic failure10.2
13spermatogenic failure 410.2
14kartagener syndrome10.1
15azoospermia due to perturbations of meiosis10.1
16intussusception10.0
17situs inversus10.0
18spermatocele10.0
19hypoxia10.0
20male infertility10.0AZF1, RBMY1A1, DAZL, DAZ4, DAZ1, BOLL
21smith magenis syndrome10.0AZF1, RBMY1A1, DAZL, DAZ1
22turner syndrome10.0RBMY1F, RBMY1J
23gonadoblastoma10.0RBMY1F, RBMY1J
24graft versus host disease9.9
25tuberculous epididymitis9.9
26acute pancreatitis9.9
27machado-joseph disease9.9
28bronchiolitis9.9
29cystadenoma9.9
30williams-beuren syndrome9.9
31arteriovenous malformation9.9
32hyperprolactinemia9.9
33sertoli cell tumor9.9
34panhypopituitarism9.9
35radioulnar synostosis9.9
36congenital adrenal hyperplasia9.9
37oculocerebrorenal syndrome9.9
38cystinosis9.9
39primary ciliary dyskinesia9.9
40hypospadias9.9
41fabry disease9.9
42synostosis9.9
43testicular disease9.9
44micro syndrome9.9
45wilms tumor9.9
46spermatogenesis arrest9.9
47deafness-infertility syndrome9.9
48visceral steatosis9.9
49pulmonic stenosis9.9
5049,xxxxy syndrome9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Clinical Features for Azoospermia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Azoospermia

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Search CenterWatch for Azoospermia

Genetic Tests for Azoospermia

Sources:
22GTR
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Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

Sources:
33MalaCards
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MalaCards organs/tissues related to Azoospermia:

33
Spinal cord, Brain, Kidney, Breast, Prostate, Testis, T cells, B cells, Testis germ

Animal Models for Azoospermia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Azoospermia

Sources:
51PubMed
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Articles related to Azoospermia:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
The importance of semen analysis in the context of azoospermia. (23503953)
2013
2
Association between glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1 and GSTP1) and idiopathic azoospermia]. (23450492)
2013
3
Prognostic factors for sperm retrieval in non-obstructive azoospermia. (23503961)
2013
4
Expression analysis of MND1/GAJ, SPATA22, GAPDHS and ACR genes in testicular biopsies from non-obstructive azoospermia (NOA) patients. (23675907)
2013
5
Perspectives on repeat sperm retrieval in nonobstructive azoospermia. (23706338)
2013
6
Micro-dissection testicular sperm extraction as an alternative for sperm acquisition in the most difficult cases of Azoospermia: Technique and preliminary results in India. (24082652)
2013
7
Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis. (24012201)
2013
8
Combined trifocal and microsurgical testicular sperm extraction is the best technique for testicular sperm retrieval in "low-chance" nonobstructive azoospermia. (22521095)
2012
9
Beneficial effect of tamoxifen on sperm recovery in infertile men with nonobstructive azoospermia. (21651602)
2012
10
Panhypopituitarism presenting as azoospermia. (22629531)
2012
11
Relationship between sperm chromatin status and ICSI outcome in men with obstructive azoospermia and unexplained infertile normozoospermia. (21655656)
2011
12
Bilateral endoscopic total extraperitoneal (TEP) inguinal hernia repair does not induce obstructive azoospermia: data of a retrospective and prospective trial. (21528415)
2011
13
Prostate cystadenoma presenting with obstructive azoospermia. (21051587)
2011
14
The prevalence of common CFTR mutations in Iranian infertile men with non-CAVD obstructive azoospermia by using ARMS PCR techniques. (21976147)
2011
15
Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia. (20676751)
2010
16
Supernumerary marker chromosome 15 in a male with azoospermia and open bite deformity. (19701220)
2009
17
Changes in plasma testosterone level and semen quality after frequent injections of GnRH analogue in a Beagle dog with azoospermia. (19887745)
2009
18
Azoospermia and severe oligospermia in testicular cancer. (19499754)
2009
19
Rapidly progressing, late-onset obstructive azoospermia linked to herniorrhaphy with mesh. (18675969)
2008
20
Vasal irrigation with sterile water and saline solution for acceleration of postvasectomy azoospermia. (18454425)
2008
21
Expression of androgen receptor co-regulators in the testes of men with azoospermia. (17919607)
2008
22
Routine screening for classical azoospermia factor deletions of the Y chromosome in azoospermic patients with Klinefelter syndrome. (17968468)
2007
23
Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia]. (17491259)
2007
24
Azoospermia: is sample centrifugation indicated? A national survey of practice and the Oxford experience. (17289038)
2007
25
Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome]. (18284064)
2007
26
Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (16824523)
2006
27
Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (16884537)
2006
28
GR/GR deletions within the azoospermia factor c region on the Y chromosome might not be associated with spermatogenic failure. (16412764)
2006
29
Synaptonemal complex--an essential role in etiology of idiopathic azoospermia]. (16520322)
2006
30
Posttreatment azoospermia in cancer patients is subgroup dependent. (16595253)
2006
31
Chromosomal abnormalities in patients with azoospermia in Western Mexico. (16443583)
2006
32
Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. (16328470)
2006
33
Y chromosome microdeletions in infertile men with idiopathic oligo- or azoospermia. (16445861)
2006
34
Induction of spermatogenesis in men with azoospermia or severe oligoteratoasthenospermia after antegrade internal spermatic vein sclerotherapy for the treatment of varicocele. (16847530)
2006
35
Constitutional mosaic trisomy 21 and azoospermia: a case report. (15719052)
2005
36
Sperm retrieval for intra-cytoplasmic sperm injection in non-obstructive azoospermia. (15951734)
2005
37
Severe hypospermatogenesis in cases of nonobstructive azoospermia: should we use fresh or frozen testicular spermatozoa? (16291973)
2005
38
Deficiency of pantothenate kinase 2 (Pank2) in mice leads to retinal degeneration and azoospermia. (15525657)
2005
39
Testicular fine needle aspiration as a diagnostic tool in non-obstructive azoospermia. (16110357)
2005
40
Factors affecting outcome after ICSI with spermatozoa retrieved from cryopreserved testicular tissue in non-obstructive azoospermia. (15901451)
2005
41
Effect of time since vasectomy and maternal age on intracytoplasmic sperm injection success in men with obstructive azoospermia after vasectomy. (15302285)
2004
42
Idiopathic non-obstructive azoospermia or severe oligozoospermia: a cross-sectional study in 61 Greek men. (15149468)
2004
43
The Azoospermia region AZFa: an evolutionar y view. (12900557)
2002
44
Inhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor C microdeletions. (12466362)
2002
45
Identification of mutation and polymorphic changes in the CFTR gene of patients with obstructive azoospermia]. (11247407)
2000
46
Microdeletions in interval 6 of the Y chromosome detected by STS-PCR in 6 of 33 patients with idiopathic oligo- or azoospermia. (8978761)
1996
47
Cystic fibrosis transmembrane conductance regulator and obstructive azoospermia. (7540706)
1995
48
A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. (8269511)
1993
49
Plasma testosterone and testosterone binding affinities in men with impotence, oligospermia, azoospermia, and hypogonadism. (4819173)
1974
50
Therapeutic effect of synthetic luteinizing hormone-releasing hormone (LH-RH) in male infertility due to idiopathic azoospermia and oligospermia. (4575636)
1973

Genetic Variations for Azoospermia

Expression for genes affiliated with Azoospermia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Azoospermia

Search GEO for disease gene expression data for Azoospermia.

Pathways for genes affiliated with Azoospermia

Compounds for genes affiliated with Azoospermia

GO Terms for genes affiliated with Azoospermia

Sources:
16Gene Ontology
See all sources

Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3DAZAP2, HSFY2, SOHLH1, MEF2D, RBMY1D, RBMY1J
2cytoplasmGO:00573711.2SOHLH1, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.3RBMY1B, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3
2cell differentiationGO:03015411.0DAZ2, DAZ3, DAZ1, DAZ4, DAZAP1, SOHLH1
3RNA splicingGO:00838010.8RBMY1J, RBMY1A1, RBMY1B, RBMY1E, RBMY1D
4mRNA processingGO:00639710.7RBMY1B, RBMY1A1, RBMY1J, RBMY1D, RBMY1E
5positive regulation of translational initiationGO:04594810.7BOLL, DAZ1, DAZL
6multicellular organismal developmentGO:00727510.6DAZ1, DAZL, BOLL, DAZ2, DAZ3, DAZ4

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00016611.2BOLL, RBMY1D, RBMY1J, RBMY1A1, RBMY1B, RBMY1E
2RNA bindingGO:00372310.9RBMY1E, RBMY1B, RBMY1J, RBMY1D, DAZAP1, DAZL
3translation activator activityGO:00849410.7BOLL, DAZ1, DAZL

Products for genes affiliated with Azoospermia

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  • Antibodies

Sources for Azoospermia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet