Aliases & Classifications for Azoospermia

MalaCards integrated aliases for Azoospermia:

Name: Azoospermia 12 36 28 51 41 14 69
Spermatogenic Failure 12 36

Classifications:



External Ids:

Disease Ontology 12 DOID:14227
ICD10 32 N46.0 N46.01
ICD9CM 34 606.0
MeSH 41 D053713
NCIt 46 C80076
UMLS 69 C0004509

Summaries for Azoospermia

Disease Ontology : 12 A male infertility disease characterized by the absence of any measurable level of sperm in semen.

MalaCards based summary : Azoospermia, also known as spermatogenic failure, is related to spermatogenic failure 4 and spermatogenic failure, y-linked, 2. An important gene associated with Azoospermia is DAZ1 (Deleted In Azoospermia 1). The drugs Metformin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and liver, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 Azoospermia is the medical condition of a man whose semen contains no sperm. It is associated with... more...

Related Diseases for Azoospermia

Diseases related to Azoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure 4 33.0 AR SYCP3
2 spermatogenic failure, y-linked, 2 32.0 DAZ1 DAZ2 DAZ3 DAZ4 DDX3Y RBMY1A1
3 spermatogenic failure, x-linked, 1 30.9 DAZ1 DAZ4 DAZL DDX3Y RBMY1A1 USP26
4 oligospermia 30.2 AR CFTR DAZ1 DAZ4
5 cryptorchidism, unilateral or bilateral 30.1 AR AZF1 DAZ1
6 infertility 29.4 DAZ1 DAZ3 DAZ4 DAZL DDX3Y FSHB
7 male infertility 27.5 AR BOLL CFTR DAZ1 DAZ2 DAZ3
8 spermatogenic failure 10 12.4
9 y chromosome infertility 11.7
10 young syndrome 11.7
11 spinocerebellar ataxia 32 11.4
12 spermatogenic failure 3 11.2
13 vas deferens, congenital bilateral aplasia of 11.1
14 vas deferens, congenital bilateral aplasia of, x-linked 10.9
15 hypogonadotropic hypogonadism 24 without anosmia 10.8
16 spermatogenic failure, x-linked, 2 10.8
17 androgen insensitivity, partial 10.8
18 46,xx sex reversal 1 10.8
19 leukoencephalopathy with dystonia and motor neuropathy 10.8
20 spermatogenic failure 12 10.8
21 spermatogenic failure 13 10.8
22 spermatogenic failure 14 10.8
23 spermatogenic failure 15 10.8
24 spermatogenic failure 22 10.8
25 spermatogenic failure 23 10.8
26 varicocele 10.2
27 cystic fibrosis 10.0
28 fibrosis of extraocular muscles, congenital, 1 10.0
29 testicular germ cell cancer 10.0 AR RBMY1A1
30 phelan-mcdermid syndrome 10.0 AZF1 DAZ1 DAZL RBMY1A1 USP9Y
31 aging 9.9
32 hypogonadism 9.9
33 intussusception 9.8
34 inguinal hernia 9.8
35 hypogonadotropic hypogonadism 9.8
36 hereditary wilms' tumor 9.8
37 testicular germ cell tumor 9.7
38 testicular germ cell tumor 1 9.7
39 wilms tumor 5 9.7
40 wilms tumor 6 9.7
41 spinal cord injury 9.7
42 hypospadias 9.7
43 spermatocele 9.7
44 leydig cell tumor 9.7
45 conjunctivitis 9.7
46 hypogonadotropism 9.7
47 situs inversus 9.7
48 germ cells tumors 9.7
49 hypoxia 9.7
50 partial deletion of y 9.7 DAZ1 DAZ2 DAZ3 DAZ4 DDX3Y RBMY1A1

Comorbidity relations with Azoospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to Azoospermia

Symptoms & Phenotypes for Azoospermia

MGI Mouse Phenotypes related to Azoospermia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.61 AR BOLL CFTR DAZ2 FKBP6 FSHB
2 reproductive system MP:0005389 9.28 AR BOLL CFTR DAZ2 FKBP6 FSHB

Drugs & Therapeutics for Azoospermia

Drugs for Azoospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 4091 14219
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Methyltestosterone Approved Phase 4,Phase 2,Phase 3,Phase 1 58-18-4 6010
4
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 58-22-0 6013
5
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
6
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
7
Enclomiphene Investigational Phase 4 15690-57-0
8 Anticoagulants Phase 4
9 Calcium, Dietary Phase 4
10 Chelating Agents Phase 4
11 Chorionic Gonadotropin Phase 4,Phase 2
12 Clomiphene Phase 4
13 Estrogen Antagonists Phase 4,Phase 3
14 Estrogen Receptor Modulators Phase 4
15 Estrogens Phase 4,Phase 3
16 Fertility Agents Phase 4
17 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
20 Hypoglycemic Agents Phase 4
21 insulin Phase 4
22 Insulin, Globin Zinc Phase 4
23 Selective Estrogen Receptor Modulators Phase 4
24 Zuclomiphene Phase 4
25 Follicle Stimulating Hormone Phase 4,Phase 3
26 Anabolic Agents Phase 4,Phase 2,Phase 3,Phase 1
27 Androgens Phase 4,Phase 2,Phase 3,Phase 1
28 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
29 Estradiol 17 beta-cypionate Phase 4
30 Estradiol 3-benzoate Phase 4
31 Estradiol valerate Phase 4 979-32-8
32 Polyestradiol phosphate Phase 4
33 Testosterone 17 beta-cypionate Phase 4,Phase 2,Phase 3,Phase 1
34
Testosterone enanthate Phase 4,Phase 2,Phase 3,Phase 1 315-37-7 9416
35 Testosterone undecanoate Phase 4,Phase 2,Phase 3,Phase 1
36 Citrate Nutraceutical Phase 4
37
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
38 Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3
39 Aromatase Inhibitors Phase 3
40 Steroid Synthesis Inhibitors Phase 3
41 Cathartics Phase 2, Phase 3
42 Gastrointestinal Agents Phase 2, Phase 3
43 Laxatives Phase 2, Phase 3
44 Castor Nutraceutical Phase 2, Phase 3
45
Goserelin Approved Phase 2 65807-02-5 5311128 47725
46
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
47
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538
48 Contraceptive Agents Phase 2,Phase 1
49 Dermatologic Agents Phase 2
50 Keratolytic Agents Phase 2

Interventional clinical trials:

(show all 48)

# Name Status NCT ID Phase Drugs
1 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
2 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
3 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
4 Natesto Effects on Testosterone, Luteinizing Hormone, Follicle Stimulating Hormone and Semen Parameters Recruiting NCT03203681 Phase 4 NATESTO® (4.5% nasal testosterone) Nasal Gel
5 FSH Treatment for Non-obstructive Azoospermic Patients Unknown status NCT02275169 Phase 3 Urofollitropin
6 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
7 The Comparison of Diagnostic TESE and TESA in Non-obstructive Azoospermic Completed NCT01210326 Phase 2, Phase 3
8 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
9 Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia Unknown status NCT02041910 Phase 1, Phase 2
10 Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls Unknown status NCT00282477 Phase 2
11 GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia Recruiting NCT02544191 Phase 2 GnRHa/ hCG/ hMG
12 RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia Recruiting NCT03323801 Phase 2 13-cis retinoic acid
13 Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility. Recruiting NCT02641769 Phase 1, Phase 2
14 MSCs For Treatment of Azoospermic Patients Recruiting NCT02025270 Phase 1, Phase 2
15 Contraception in Normal and Subnormal Men Terminated NCT00167141 Phase 2 injection of hormonal male contraceptive
16 Study of the Safety, and Sperm and Gonadotropin Suppression of a Contraceptive Gel in Normal Men Completed NCT00891228 Phase 1 Testosterone;Nestorone®;Nestorone®;Nestorone®
17 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799
18 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
19 Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia Unknown status NCT01178463
20 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173
21 Isolation of the Spermatic Cord in Mesh Inguinal Hernia Repair Unknown status NCT01391455
22 A Preliminary Study on Effect of Omega-3 on Human Sperm Unknown status NCT00479960 Early Phase 1
23 Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia Completed NCT02255396
24 Insulin Resistance in Idiopathic Oligospermia and Azoospermia Completed NCT01509482
25 Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA) Completed NCT00484081
26 The Acceptance, Safety, and Efficacy of MadaJet Versus Needle Injection for Sperm Retrieval in Patients With Azoospermia Completed NCT03181243
27 Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility Completed NCT02339272
28 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
29 Obtaining Undifferentiated Cells From Testis Biopsy Completed NCT01375062
30 Genetic Studies Spermatogenic Failure Completed NCT00548977
31 Chromosomal and Morphological Structure of Mature and Immature Male Germ Cells and Recognition of IL-18 in Testicular Tissue of Azoospermic Men Completed NCT00544089
32 Testicular Function After Iodine 131 Therapy in Papillary Carcinoma Patients Completed NCT01150318 Administration of 131 iodine
33 Role of the Toxic Metal Cadmium in the Mechanism Producing Infertility With a Varicocele Completed NCT00044369
34 Secretory Azoospermia and FDG (Fluoro Deoxyglucose) PET-CT Recruiting NCT02043444
35 Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism Recruiting NCT02137265 Clomiphene;Placebo
36 Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration Recruiting NCT03291522
37 HPV as a Possible Cause of Azoospermia Recruiting NCT02329275
38 Fertility Preservation in Cases of Klinefelter Syndrome. Recruiting NCT01918280
39 Treatment of Severe Male Infertility - Predictive Factors (Imaging) Recruiting NCT02931721
40 Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility Recruiting NCT02932865
41 Reproductive Capacity and Iron Burden in Thalassemia Recruiting NCT02308904
42 Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track Active, not recruiting NCT02773498
43 Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia Enrolling by invitation NCT02851966
44 Quantitative MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile Male Enrolling by invitation NCT02756325
45 Testis Needle Aspiration of Sperm in Men With Azoospermia Not yet recruiting NCT02418832
46 TESE and Non Obstructive Azoospermia Not yet recruiting NCT03146260
47 Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk Terminated NCT00820287
48 PET-MRI for Functional Imaging of the Testis: A Feasibility Study Withdrawn NCT02669108

Search NIH Clinical Center for Azoospermia

Cochrane evidence based reviews: azoospermia

Genetic Tests for Azoospermia

Genetic tests related to Azoospermia:

# Genetic test Affiliating Genes
1 Azoospermia 28

Anatomical Context for Azoospermia

MalaCards organs/tissues related to Azoospermia:

38
Testis, Testes, Liver, Bone Marrow, Bone, Kidney, Spinal Cord

Publications for Azoospermia

Articles related to Azoospermia:

(show top 50) (show all 891)
# Title Authors Year
1
Surgical management of azoospermia: can the NHS England Clinical Commissioning Policy reduce geographical inequality of services? ( 29105258 )
2018
2
Association of the common SNPs in RNF212, STAG3 and RFX2 gene with male infertility with azoospermia in Chinese population. ( 29277047 )
2018
3
<i>DMC1</i> mutation that causes human non-obstructive azoospermia and premature ovarian insufficiency identified by whole-exome sequencing. ( 29331980 )
2018
4
Investigation of piwi-interacting RNA pathway genes role in idiopathic non-obstructive azoospermia. ( 29317647 )
2018
5
Transplantation of Spermatogonial Stem Cells Suspension into Rete Testis of Azoospermia Mouse Model. ( 29250763 )
2018
6
Microdissection testicular sperm extraction (micro-TESE): Predictive value of preoperative hormonal levels and pathology in non-obstructive azoospermia. ( 29413225 )
2018
7
Usefulness of Testicular Volume, Apparent Diffusion Coefficient, and Normalized Apparent Diffusion Coefficient in the MRI Evaluation of Infertile Men With Azoospermia. ( 29364721 )
2018
8
Re: Fertility Outcomes After Extended Searches for Ejaculated Spermatozoa in Men with Virtual Azoospermia. ( 29162350 )
2018
9
Primary Ovarian Insufficiency and Azoospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation. ( 29240891 )
2018
10
Analysis of CDK2 mutations in Chinese men with non-obstructive azoospermia who underwent testis biopsy. ( 29373224 )
2018
11
Single-nucleotide polymorphisms in the human RAD21L gene may be a genetic risk factor for Japanese patients with azoospermia caused by meiotic arrest and Sertoli cell-only syndrome. ( 28635411 )
2017
12
Distinguishing non-obstructive azoospermia from obstructive azoospermia in Taiwanese patients by hormone profile and testis size. ( 29079114 )
2017
13
Loss of SLC9A3 decreases CFTR protein and causes obstructed azoospermia in mice. ( 28384194 )
2017
14
Untargeted metabolomic profiling of seminal plasma in non-obstructive azoospermia men: a non-invasive detection of spermatogenesis. ( 28058728 )
2017
15
Screening of Two Neighboring CFTR Mutations in Iranian Infertile Men with Non-Obstructive Azoospermia. ( 28042420 )
2017
16
Y Chromosome Microdeletions in Infertile Men with Non-obstructive Azoospermia and Severe Oligozoospermia. ( 29062795 )
2017
17
Azoospermia Factor C Subregion of the Y Chromosome. ( 29430151 )
2017
18
Biological therapy for non-obstructive azoospermia. ( 28927307 )
2017
19
Effectiveness of highly purified urofollitropin treatment in patients with idiopathic azoospermia before testicular sperm extraction. ( 28799634 )
2017
20
The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. ( 28367414 )
2017
21
Embryonic stem cell derived germ cells induce spermatogenesis after transplantation into the testes of an adult mouse azoospermia model. ( 28768794 )
2017
22
Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors. ( 28727831 )
2017
23
Leydig cell tumor of the testis, presenting with azoospermia. ( 29259494 )
2017
24
Pathological changes in Sertoli cells and dysregulation of divalent metal transporter 1 with iron responsive element inA the testes of idiopathic azoospermia patients. ( 28762519 )
2017
25
Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort. ( 28868835 )
2017
26
Evidence for the involvement of the proximal copy of the MAGEA9 gene in Xq28-linked CNV67 specific to spermatogenic failure. ( 28339631 )
2017
27
Mutation in TDRD9 causes non-obstructive azoospermia in infertile men. ( 28536242 )
2017
28
Two Novel TEX15 Mutations in a Family with Nonobstructive Azoospermia. ( 28355598 )
2017
29
Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia. ( 29404532 )
2017
30
CFTR gene mutations and polymorphism are associated with non-obstructive azoospermia: From case-control study. ( 28456595 )
2017
31
CUL4B mutations are uncommon in Japanese patients with Sertoli-cell-only syndrome and azoospermia. ( 28816568 )
2017
32
Abnormal synapses, recombination, and impaired double-strand break repair in a man with nonobstructive azoospermia. ( 29271398 )
2017
33
A step-by-step guide to office-based sperm retrieval for obstructive azoospermia. ( 28904906 )
2017
34
Association of FAS-670A/G and FASL-844C/T polymorphisms with idiopathic azoospermia in Western Iran. ( 28942044 )
2017
35
Validation and application of a novel integrated genetic screening method to a cohort of 1,112 men with idiopathic azoospermia or severe oligozoospermia. ( 28801929 )
2017
36
Reduced microRNA-188-3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia. ( 27868267 )
2017
37
Molecular characterisation of a case of dicentric Y presented as nonobstructive azoospermia with testicular early maturation arrest. ( 28836280 )
2017
38
R383C mutation of human CDC20 results in idiopathic non-obstructive azoospermia. ( 29245942 )
2017
39
Human PIWI (HIWI) is an azoospermia factor. ( 28801861 )
2017
40
A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes. ( 28206990 )
2017
41
Relationship of genetic causes and inhibin B in non obstructive azoospermia spermatogenic failure. ( 28874128 )
2017
42
Re: Prediction Model for Obtaining Spermatozoa with Testicular Sperm Extraction in Men with Non-Obstructive Azoospermia. ( 29370621 )
2017
43
Obstructive azoospermia caused by low ligation of varicocele: A case report. ( 28771041 )
2017
44
A case of azoospermia in a non-destructive testingA worker exposed to radiation. ( 28815050 )
2017
45
Transcriptome-wide association study revealed two novel genes associated with nonobstructive azoospermia in a Chinese population. ( 29202958 )
2017
46
Loss-of-function mutations in TDRD7 lead to a rare novel syndrome combining congenital cataract and nonobstructive azoospermia in humans. ( 28837160 )
2017
47
Paternal age as an independent factor does not affect embryo quality and pregnancy outcomes of testicular sperm extraction-intracytoplasmic sperm injection in azoospermia. ( 28703337 )
2017
48
Next-generation sequencing for patients with non-obstructive azoospermia: implications for significant roles of monogenic/oligogenic mutations. ( 28718531 )
2017
49
Multicenter study of genetic abnormalities associated with severe oligospermia and non-obstructive azoospermia. ( 28730893 )
2017
50
DiGeorge Syndrome Associated with Azoospermia: First case in the literature. ( 28861318 )
2017

Variations for Azoospermia

Copy number variations for Azoospermia from CNVD:

7 (show all 15)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 218759 7 116907252 117095954 Genomic rearrangement CFTR Azoospermia
2 266752 Y 1 57772954 Microdeletion Azoospermia
3 266760 Y 1 57772954 Microdeletions Azoospermia
4 266846 Y 11300000 57772954 Microdeletio Azoospermia
5 266849 Y 11300000 57772954 Microdeletion Azoospermia
6 266862 Y 11300000 57772954 Microdeletion DAZ Azoospermia
7 266959 Y 174481503 174538309 Deletion AZF Spermatogenic Failure
8 266963 Y 174481503 174538309 Microdeletion AZF Azoospermia
9 266968 Y 174481503 174538309 Microdeletion AZFA Azoospermia
10 266969 Y 174481503 174538309 Microdeletion AZFA Azoospermia
11 267104 Y 23539797 25607639 Deletion BPY2 Azoospermia
12 267118 Y 23684889 23754627 Deletion DAZ Azoospermia
13 267153 Y 24600763 26180436 Deletion CDY1 Azoospermia
14 267157 Y 24738968 26042240 Deletion CSPG4LY Azoospermia
15 267158 Y 24765501 26015710 Deletion GOLGA2LY Azoospermia

Expression for Azoospermia

Search GEO for disease gene expression data for Azoospermia.

Pathways for Azoospermia

GO Terms for Azoospermia

Cellular components related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.23 AR CFTR DAZ1 DAZ2 DAZ3 DAZ4
2 synaptonemal complex GO:0000795 9.13 FKBP6 SYCP3 TEX11
3 nucleus GO:0005634 10.07 AR DAZ1 DAZ2 DAZ3 DAZ4 DAZAP1
4 cytoplasm GO:0005737 10 AR BOLL CFTR DAZ1 DAZ2 DAZ3

Biological processes related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.97 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZAP1
2 cell differentiation GO:0030154 9.97 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZAP1
3 protein deubiquitination GO:0016579 9.73 AR CFTR USP26 USP9Y
4 germ cell development GO:0007281 9.73 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
5 meiotic cell cycle GO:0051321 9.71 BOLL FKBP6 SYCP3 TEX11
6 spermatogenesis GO:0007283 9.7 AR BOLL DAZ1 DAZ2 DAZ3 DAZ4
7 positive regulation of translational initiation GO:0045948 9.63 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
8 3-UTR-mediated mRNA stabilization GO:0070935 9.1 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL

Molecular functions related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.91 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZAP1
2 mRNA binding GO:0003729 9.7 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
3 mRNA 3-UTR binding GO:0003730 9.43 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
4 translation activator activity GO:0008494 9.1 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL

Sources for Azoospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....