MCID: AZS001
MIFTS: 44

Azoospermia malady

Summaries for Azoospermia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards: Azoospermia is related to infertility and oligospermia. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord.

Description from OMIM:46 415000

Aliases & Classifications for Azoospermia

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8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM
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Aliases & Descriptions:

azoospermia 8 22 10 44 60


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Disease Ontology8 DOID:14227
ICD9CM27 606.0
MeSH34 D053713
OMIM46 415000

Related Diseases for Azoospermia

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17GeneCards, 18GeneDecks
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Diseases in the Azoospermia family:

Azoospermia Due to Perturbations of Meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.2DAZ2, DAZ1, DAZ4, DAZL, SYCP3, SOHLH1
2oligospermia30.9DAZ1, DAZ2
3male infertility30.8AZF1, RBMY1A1, DAZL, DAZ4, DAZ1, BOLL
4y chromosome infertility30.4DAZ1, RBMY1A1, HSFY1
5sertoli cell-only syndrome30.4DAZ2, DAZ1
6cryptorchidism30.3DAZ1, AZF1
7varicocele10.5
8cystic fibrosis10.3
9young syndrome10.3
10hypogonadism10.2
11testicular cancer10.2
12spermatogenic failure 410.2
13azoospermia due to perturbations of meiosis10.1
14klinefelter's syndrome10.0
15intussusception10.0
16situs inversus10.0
17spermatocele10.0
18hypogonadotropism10.0
19sarcoidosis10.0
20smith magenis syndrome10.0AZF1, RBMY1A1, DAZL, DAZ1
21turner syndrome10.0RBMY1F, RBMY1J
22gonadoblastoma10.0RBMY1F, RBMY1J
23graft versus host disease9.9
24ureteral obstruction9.9
25tuberculous epididymitis9.9
26acute pancreatitis9.9
27machado-joseph disease9.9
28bronchiolitis9.9
29cystadenoma9.9
30williams-beuren syndrome9.9
31arteriovenous malformation9.9
32hyperprolactinemia9.9
33sertoli cell tumor9.9
34panhypopituitarism9.9
35radioulnar synostosis9.9
36congenital adrenal hyperplasia9.9
37oculocerebrorenal syndrome9.9
38cystinosis9.9
39primary ciliary dyskinesia9.9
40hypospadias9.9
41fabry disease9.9
42pantothenate kinase-associated neurodegeneration9.9
43chromosomal disease9.9
44conjunctivitis9.9
45hodgkin's lymphoma9.9
46hydrocele9.9
47impotence9.9
48myotonic disease9.9
49myotonic dystrophy9.9
50obesity9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Clinical Features for Azoospermia

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46OMIM
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Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Azoospermia

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Search CenterWatch for Azoospermia

Genetic Tests for Azoospermia

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22GTR
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Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

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32MalaCards
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MalaCards organs/tissues related to Azoospermia:

32
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

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Publications for Azoospermia

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50PubMed
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Articles related to Azoospermia:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. (23550190)
2013
2
Re: Optimization of spermatogenesis-regulating hormones in patients with non-obstructive azoospermia and its impact on sperm retrieval: a multicentre study. (24209557)
2013
3
HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients. (23934009)
2013
4
The effect of human chorionic gonadotropin-based hormonal therapy on intratesticular testosterone levels and spermatogonial DNA synthesis in men with non-obstructive azoospermia. (24123916)
2013
5
A rare case of obstructive azoospermia due to compression of the seminal vesicle and ejaculatory duct by a large lower ureteric stone. (23546036)
2013
6
Comparative proteomic analysis coupled with conventional protein assay as a strategy to identify predictors of successful testicular sperm extraction in patients with non-obstructive azoospermia. (23427166)
2013
7
Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. (23559187)
2013
8
Deleted in azoospermia-like enhances in vitro derived porcine germ cell formation and meiosis. (23259838)
2013
9
Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients. (22407170)
2012
10
Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia. (21625623)
2011
11
Successful repeat microdissection testicular sperm extraction in men with nonobstructive azoospermia. (21247600)
2011
12
Incidence of microdeletions in the AZF region of the Y chromosome in Slovak patients with azoospermia. (21475375)
2011
13
Appropriate cut-off value for follicle-stimulating hormone in azoospermia to predict spermatogenesis. (20825644)
2010
14
Epididymovasostomy as the first-line treatment of obstructive azoospermia in young couples with normal spermatogenesis. (20219429)
2010
15
Analysis of azoospermia factor loci polymorphisms among Tunisian infertile men with varicocele. (20818979)
2010
16
LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest. (19806447)
2009
17
XPC gene polymorphisms and risk of idiopathic azoospermia or oligozoospermia in a Chinese population. (18067564)
2009
18
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
19
Microdissection testicular sperm extraction and IVF-ICSI outcome in nonobstructive azoospermia. (18727731)
2008
20
The management of infertility due to obstructive azoospermia. (19007607)
2008
21
Massive deletion in AZFb/b+c and azoospermia with Sertoli cell only and/or maturation arrest. (17877719)
2008
22
Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. (17172283)
2007
23
Azoospermia factor microdeletion on Y chromosome in patients with idiopathic azoospermia or severe oligozoospermia]. (17478930)
2007
24
DNA repair gene XRCC1 and XPD polymorphisms and the risk of idiopathic azoospermia in a Chinese population. (17912469)
2007
25
Role of transcription factors Ad4bp/SF-1 and DAX-1 in steroidogenesis and spermatogenesis in human testicular development and idiopathic azoospermia. (16834661)
2006
26
Associations of homologous RNA-binding motif gene on the X chromosome (RBMX) and its like sequence on chromosome 9 (RBMXL9) with non-obstructive azoospermia. (16491274)
2006
27
Expression and distribution of OCTN2 in mouse epididymis and its association with obstructive azoospermia in juvenile visceral steatosis mice. (16734862)
2006
28
How successful is repeat testicular sperm extraction in patients with azoospermia? (16473930)
2006
29
Report on management of obstructive azoospermia. (17055837)
2006
30
Salvage microdissection testicular sperm extraction after failed conventional testicular sperm extraction in patients with nonobstructive azoospermia. (16516017)
2006
31
The Caenorhabditis elegans homologue of deleted in azoospermia is involved in the sperm/oocyte switch. (16641369)
2006
32
Cumulative pregnancy rate after ICSI with cryopreserved testicular tissue in non-obstructive azoospermia. (15901452)
2005
33
Herniorrhaphy with polypropylene mesh causing inguinal vasal obstruction: a preventable cause of obstructive azoospermia. (15798455)
2005
34
The diagnosis of azoospermia depends on the force of centrifugation. (15820801)
2005
35
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (15081113)
2004
36
Fine-needle aspiration cytology of the testis: can it be a single diagnostic modality in azoospermia? (15263788)
2004
37
Fresh testicular sperm from men with nonobstructive azoospermia works best for ICSI. (15596170)
2004
38
Spermatogonial proliferation patterns in men with azoospermia of different etiologies. (14607570)
2003
39
Influence of motility on the outcome of in vitro fertilization/intracytoplasmic sperm injection with fresh vs. frozen testicular sperm from men with obstructive azoospermia. (12969692)
2003
40
Pregnancy outcome and neonatal data of children born after ICSI using testicular sperm in obstructive and non-obstructive azoospermia. (14507827)
2003
41
Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells. (12649345)
2003
42
Identification of target messenger RNA substrates for the murine deleted in azoospermia-like RNA-binding protein. (11804965)
2002
43
Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. (11726576)
2001
44
Decreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosome. (11157822)
2001
45
Absence of Y chromosome microdeletions involving the DAZ (deleted in azoospermia) and RBM (ribonucleic acid-binding motif) genes in patients with chordee without hypospadias. (10959496)
2000
46
Investigation of occurrence of deletion of the DAZ gene among men with azoospermia and severe oligozoospermia]. (9695355)
1998
47
Hyperprolactinemia in men with asthenozoospermia, oligozoospermia, or azoospermia. (9140616)
1997
48
Short stature and azoospermia in a patient with Y chromosome long arm deletion. (9438922)
1997
49
Substantial prevalence of microdeletions of the Y-chromosome in infertile men with idiopathic azoospermia and oligozoospermia detected using a sequence-tagged site-based mapping strategy. (8636331)
1996
50
Serum bioactive follicle-stimulating hormone in men with idiopathic azoospermia and oligospermia. (3116028)
1987

Genetic Variations for Azoospermia

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Expression for genes affiliated with Azoospermia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Azoospermia

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Pathways for genes affiliated with Azoospermia

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Compounds for genes affiliated with Azoospermia

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GO Terms for genes affiliated with Azoospermia

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16Gene Ontology
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Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3DAZAP2, HSFY2, SOHLH1, MEF2D, RBMY1D, RBMY1J
2cytoplasmGO:00573711.2SOHLH1, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.3BOLL, SOHLH1, RBMY1J, RBMY1B, DAZAP1, DAZL
2cell differentiationGO:03015411.0SOHLH1, DAZAP1, DAZ4, DAZ1, DAZ3, DAZ2
3RNA splicingGO:00838010.8RBMY1E, RBMY1B, RBMY1A1, RBMY1J, RBMY1D
4mRNA processingGO:00639710.7RBMY1E, RBMY1B, RBMY1A1, RBMY1J, RBMY1D
5positive regulation of translational initiationGO:04594810.7DAZL, DAZ1, BOLL
6multicellular organismal developmentGO:00727510.6DAZL, DAZ4, DAZ1, DAZ3, DAZ2, BOLL

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00016611.2BOLL, RBMY1D, RBMY1J, RBMY1A1, RBMY1B, RBMY1E
2RNA bindingGO:00372310.9RBMY1E, RBMY1B, RBMY1J, RBMY1D, DAZAP1, DAZL
3translation activator activityGO:00849410.7BOLL, DAZ1, DAZL

Products for genes affiliated with Azoospermia

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Sources for Azoospermia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet