MCID: AZS001
MIFTS: 44

Azoospermia malady

Summaries for Azoospermia

About this section
Sources:
63Wikipedia, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards: Azoospermia is related to infertility and oligospermia. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord.

Description from OMIM:46 415000

Aliases & Classifications for Azoospermia

About this section
Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 27ICD9CM, 56SNOMED-CT, 34MeSH, 46OMIM
See all sources

Aliases & Descriptions:

azoospermia 8 22 10 44 60


External Ids:

Disease Ontology8 DOID:14227
ICD9CM27 606.0
MeSH34 D053713
OMIM46 415000

Related Diseases for Azoospermia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Azoospermia family:

Azoospermia Due to Perturbations of Meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.2DAZ2, DAZ1, DAZ4, DAZL, SYCP3, SOHLH1
2oligospermia30.9DAZ1, DAZ2
3male infertility30.8AZF1, RBMY1A1, DAZL, DAZ4, DAZ1, BOLL
4y chromosome infertility30.4DAZ1, RBMY1A1, HSFY1
5sertoli cell-only syndrome30.4DAZ2, DAZ1
6cryptorchidism30.3DAZ1, AZF1
7varicocele10.5
8cystic fibrosis10.3
9young syndrome10.3
10hypogonadism10.2
11testicular cancer10.2
12spermatogenic failure 410.2
13azoospermia due to perturbations of meiosis10.1
14klinefelter's syndrome10.0
15intussusception10.0
16situs inversus10.0
17spermatocele10.0
18hypogonadotropism10.0
19sarcoidosis10.0
20smith magenis syndrome10.0AZF1, RBMY1A1, DAZL, DAZ1
21turner syndrome10.0RBMY1F, RBMY1J
22gonadoblastoma10.0RBMY1F, RBMY1J
23graft versus host disease9.9
24ureteral obstruction9.9
25tuberculous epididymitis9.9
26acute pancreatitis9.9
27machado-joseph disease9.9
28bronchiolitis9.9
29cystadenoma9.9
30williams-beuren syndrome9.9
31arteriovenous malformation9.9
32hyperprolactinemia9.9
33sertoli cell tumor9.9
34panhypopituitarism9.9
35radioulnar synostosis9.9
36congenital adrenal hyperplasia9.9
37oculocerebrorenal syndrome9.9
38cystinosis9.9
39primary ciliary dyskinesia9.9
40hypospadias9.9
41fabry disease9.9
42pantothenate kinase-associated neurodegeneration9.9
43chromosomal disease9.9
44conjunctivitis9.9
45hodgkin's lymphoma9.9
46hydrocele9.9
47impotence9.9
48myotonic disease9.9
49myotonic dystrophy9.9
50obesity9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Clinical Features for Azoospermia

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Azoospermia

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Search CenterWatch for Azoospermia

Genetic Tests for Azoospermia

About this section
Sources:
22GTR
See all sources

Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Azoospermia:

32
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

About this section

Publications for Azoospermia

About this section
Sources:
50PubMed
See all sources

Articles related to Azoospermia:

(show top 50)    (show all 622)
idTitleAuthorsYear
1
rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia. (23993922)
2013
2
Percutaneous epididymal sperm aspiration and short time insemination in the treatment of men with obstructive azoospermia. (23989999)
2013
3
Cysteine-rich secretory protein 1 in seminal plasma: potential biomarker for the distinction between obstructive and nonobstructive azoospermia. (23987519)
2013
4
Ongoing graft-versus-host disease is a risk factor for azoospermia after allogeneic hematopoietic stem cell transplantation: a survey of the Late Effects Working Party of the European Group for Blood and Marrow Transplantation. (22929982)
2013
5
A dominant-negative mutation of HSF2 associated with idiopathic azoospermia. (23064888)
2013
6
Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu. (22669085)
2012
7
Discordant clinical and histological findings predict failure of reconstruction in suspected obstructive azoospermia. (22557716)
2012
8
Association between XRCC1 single-nucleotide polymorphisms and infertility with idiopathic azoospermia in northern Chinese Han males. (22868082)
2012
9
Quantification studies in human seminal plasma samples identify prolactin inducible protein as a plausible marker of azoospermia. (22724438)
2012
10
A rational approach to the management of varicocele-associated nonobstructive azoospermia. (21183173)
2011
11
The TNP1 haplotype - GCG is associated with azoospermia. (20522125)
2011
12
Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. (21460039)
2011
13
The value of epididymal protease inhibitor in differential diagnosis between obstructive azoospermia and non-obstructive azoospermia. (21951200)
2011
14
Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men. (20505168)
2010
15
Eppin, a novel marker to differentially diagnose azoospermia? (20800364)
2010
16
Cytogenetic abnormalities and azoospermia factor (AZF) microdeletions in infertile men from Kuwait. (20589193)
2010
17
Azoospermia in an 8-month-old boar due to bilateral obstruction at the testis/epididymis interface. (21197205)
2010
18
Pregnancies achieved by testicular sperm recovery in male hypogonadotrophic hypogonadism with persistent azoospermia. (19400984)
2009
19
Mutation of KLHL-10 in idiopathic infertile males with azoospermia, oligospermia or asthenospermia]. (20218307)
2009
20
Polyorchidism in a patient with azoospermia. (19587516)
2009
21
Cytogenetic and Y chromosome microdeletion screening studies in infertile males with Oligozoospermia and Azoospermia in Southeast Turkey. (18953646)
2008
22
Molecular cytogenetic studies of 25 males with azoospermia]. (18393244)
2008
23
Azoospermia with Klippel-Feil anomaly. (18269464)
2008
24
Re: Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (18399835)
2008
25
Association of TGIFLX/Y mRNA expression with azoospermia in infertile men. (18384077)
2008
26
Semen evaluation for verification of azoospermia after vasectomy in chimpanzees (Pan troglodytes). (17877328)
2007
27
Rapid detection of sex chromosomal aneuploidies by QF-PCR: application in 200 men with severe oligozoospermia or azoospermia. (17627384)
2007
28
Testicular sperm extraction and ICSI in patients with post-chemotherapy non-obstructive azoospermia. (17453682)
2007
29
Deprivation of pantothenic acid elicits a movement disorder and azoospermia in a mouse model of pantothenate kinase-associated neurodegeneration. (17429753)
2007
30
Hydroxyurea therapy: a rare cause of reversible azoospermia. (17333529)
2007
31
Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia. (16888682)
2007
32
Fine mapping of re-arranged Y chromosome in three infertile patients with non-obstructive azoospermia/cryptozoospermia. (17582144)
2007
33
Uniform testicular maturation arrest: a unique subset of men with nonobstructive azoospermia. (17570432)
2007
34
Vasal obstruction after hernioplasty: the importance of surgical strategy in preventing azoospermia. (16794407)
2006
35
Uniform deletion junctions of complete azoospermia factor region c deletion in infertile men in Taiwan. (16491273)
2006
36
Chromosomal abnormality and Y chromosome microdeletion in Chinese patients with azoospermia or severe oligozoospermia. (16529294)
2006
37
Cytogenetic and molecular analysis of male infertility: Y chromosome deletion during nonobstructive azoospermia and severe oligozoospermia. (16456245)
2006
38
Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia. (16227348)
2005
39
Etiology of azoospermia in 100 consecutive nonvasectomized men. (15533383)
2004
40
Azoospermia in testicular sarcoidosis is an indication for corticosteroid therapy. (15589877)
2004
41
Percutaneous epididymal sperm aspiration (PESA) in men with obstructive azoospermia. (15745497)
2003
42
Testicular sperm retrieval in the management of chemotherapy induced azoospermia. (14581502)
2003
43
Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. (12042281)
2002
44
Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. (10376575)
1999
45
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
46
Azoospermia and oligospermia among a large cohort of DBCP applicators in 12 countries. (10330512)
1999
47
Follitropin (FSH) deficiency in an infertile male due to FSHbeta gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations. (9806482)
1998
48
Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11. (8817327)
1996
49
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (916056)
1977
50
Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among levels of plasma follicle stimulating hormone, testosterone and testicular pathology in patients with severe oligospermia and/or azoospermia. (1030546)
1976

Genetic Variations for Azoospermia

About this section

Expression for genes affiliated with Azoospermia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Azoospermia

Search GEO for disease gene expression data for Azoospermia.

Pathways for genes affiliated with Azoospermia

About this section

Compounds for genes affiliated with Azoospermia

About this section

GO Terms for genes affiliated with Azoospermia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563411.3DAZAP2, HSFY2, SOHLH1, MEF2D, RBMY1D, RBMY1J
2cytoplasmGO:00573711.2SOHLH1, DAZAP1, DAZL, DAZ4, DAZ1, DAZ3

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.3BOLL, SOHLH1, RBMY1J, RBMY1B, DAZAP1, DAZL
2cell differentiationGO:03015411.0SOHLH1, DAZAP1, DAZ4, DAZ1, DAZ3, DAZ2
3RNA splicingGO:00838010.8RBMY1E, RBMY1B, RBMY1A1, RBMY1J, RBMY1D
4mRNA processingGO:00639710.7RBMY1E, RBMY1B, RBMY1A1, RBMY1J, RBMY1D
5positive regulation of translational initiationGO:04594810.7DAZL, DAZ1, BOLL
6multicellular organismal developmentGO:00727510.6DAZL, DAZ4, DAZ1, DAZ3, DAZ2, BOLL

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleotide bindingGO:00016611.2BOLL, RBMY1D, RBMY1J, RBMY1A1, RBMY1B, RBMY1E
2RNA bindingGO:00372310.9RBMY1E, RBMY1B, RBMY1J, RBMY1D, DAZAP1, DAZL
3translation activator activityGO:00849410.7BOLL, DAZ1, DAZL

Products for genes affiliated with Azoospermia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Azoospermia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet