MCID: AZS001
MIFTS: 45

Azoospermia malady

Genetic diseases (common), Reproductive diseases categories
Download this MalaCard

Summaries for Azoospermia

About this section
Sources:
65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Azoospermia is the medical condition of a man not having any measurable level of sperm in his semen. It... more...

MalaCards: Azoospermia is related to infertility and oligospermia. An important gene associated with Azoospermia is DAZL (deleted in azoospermia-like). Affiliated tissues include testis, testes and spinal cord, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Description from OMIM:47 415000

Aliases & Classifications for Azoospermia

About this section
Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 47OMIM, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Reproductive diseases


Aliases & Descriptions:

azoospermia 8 22 10 45 62


External Ids:

Disease Ontology8 DOID:14227
MeSH35 D053713
OMIM47 415000
ICD9CM27 606.0

Related Diseases for Azoospermia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Azoospermia family:

Azoospermia Due to Perturbations of Meiosis

Diseases related to Azoospermia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1infertility31.0DAZL, DAZ1, DAZ4, DAZ2, AZF1, SOHLH1
2oligospermia31.0DAZ2, DAZ1
3male infertility30.7DAZL, DAZ3, HSFY1
4cryptorchidism30.4AZF1, DAZ1
5sertoli cell-only syndrome30.4DAZ1, DAZ2
6y chromosome infertility30.4RBMY1A1, HSFY1, DAZ1
7klinefelter's syndrome30.1AZF1, DAZ4
8varicocele10.5
9epididymitis10.5
10cystic fibrosis10.3
11young syndrome10.3
12hypogonadism10.2
13spermatogenic failure10.2
14azoospermia due to perturbations of meiosis10.1
15intussusception10.0
16situs inversus10.0
17spermatocele10.0
18hypogonadotropism10.0
19sarcoidosis10.0
20hypoxia10.0
21spinal cord injury10.0
22spinocerebellar ataxia 3210.0
23smith magenis syndrome10.0DAZL, DAZ1, AZF1, RBMY1A1
24graft versus host disease9.9
25williams-beuren syndrome9.9
26cystadenoma9.9
27bronchiolitis9.9
28machado-joseph disease9.9
29acute pancreatitis9.9
30tuberculous epididymitis9.9
31panhypopituitarism9.9
32congenital adrenal hyperplasia9.9
33oculocerebrorenal syndrome9.9
34cystinosis9.9
35primary ciliary dyskinesia9.9
36hypospadias9.9
37radioulnar synostosis9.9
38arteriovenous malformation9.9
39hyperprolactinemia9.9
40fabry disease9.9
41pantothenate kinase-associated neurodegeneration9.9
42conjunctivitis9.9
43hodgkin's lymphoma9.9
44hydrocele9.9
45impotence9.9
46myotonic dystrophy9.9
47obesity9.9
48pancreatitis9.9
49prostatitis9.9
50retinal degeneration9.9

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to azoospermia

Symptoms for Azoospermia

About this section
Sources:
47OMIM
See all sources


Clinical features from OMIM:

415000

Drugs & Therapeutics for Azoospermia

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Azoospermia

Search NIH Clinical Center for Azoospermia

Genetic Tests for Azoospermia

About this section
Sources:
22GTR
See all sources

Genetic tests related to Azoospermia:

id Genetic test Affiliating Genes
1 Azoospermia22

Anatomical Context for Azoospermia

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Azoospermia:

33
Testis, Testes, Spinal cord, Brain, Kidney, Breast, Prostate

Animal Models for Azoospermia or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Azoospermia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8DAZAP1, SOHLH1, SYCP3, BOLL, DAZL
2MP:00053798.5BOLL, SYCP3, SOHLH1, DAZAP1, DAZL

Publications for Azoospermia

About this section
Sources:
52PubMed
See all sources

Articles related to Azoospermia:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
rs189037, a functional variant in ATM gene promoter, is associated with idiopathic nonobstructive azoospermia. (23993922)
2013
2
Non-chimerism and chimerism pseudo dicentric Y chromosome: two case reports about azoospermia and cytogenetic/molecular genetic analysis in the Chinese population. (23504399)
2013
3
Outcome of intracytoplasmic sperm injection cycles with fresh testicular spermatozoa obtained on the day of or the day before oocyte collection and with cryopreserved testicular sperm in patients with azoospermia. (23891272)
2013
4
Different cystic fibrosis transmembrane conductance regulator mutations in Chinese men with congenital bilateral absence of vas deferens and other acquired obstructive azoospermia. (23953609)
2013
5
Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate. (23550190)
2013
6
The importance of semen analysis in the context of azoospermia. (23503953)
2013
7
Overweight men with nonobstructive azoospermia have worse pregnancy outcomes after microdissection testicular sperm extraction. (23122830)
2013
8
Microdissection testicular sperm extraction (micro-TESE) as a sperm acquisition method for men with nonobstructive azoospermia seeking fertility: operative and laboratory aspects. (23849579)
2013
9
Medical management of non-obstructive azoospermia. (23503956)
2013
10
Midkine promotes proliferation of primordial germ cells by inhibiting the expression of the deleted in azoospermia-like gene. (22564978)
2012
11
ICSI outcome of patients with severe oligospermia vs. non-obstructive azoospermia. (22905450)
2012
12
The value of testicular 'mapping' in men with non-obstructive azoospermia. (21258355)
2011
13
High risk of azoospermia in men treated for childhood cancer. (20345878)
2011
14
Gene copy number reduction in the azoospermia factor c (AZFc) region and its effect on total motile sperm count. (21429917)
2011
15
Varicocele repair in patients with nonobstructive azoospermia: a meta-analysis. (20400156)
2010
16
Long-term proliferation and characterization of human spermatogonial stem cells obtained from obstructive and non-obstructive azoospermia under exogenous feeder-free culture conditions. (20590666)
2010
17
Differential diagnosis of azoospermia and etiologic classification of obstructive azoospermia: role of scrotal and transrectal US. (20515977)
2010
18
Genetic anomalies in patients with severe oligozoospermia and azoospermia in eastern Turkey: a prospective study. (19731213)
2009
19
Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. (17941933)
2008
20
Rapidly progressing, late-onset obstructive azoospermia linked to herniorrhaphy with mesh. (18675969)
2008
21
Tag STS in the AZF region associated with azoospermia in a Tunisian population. (17409464)
2007
22
Semen evaluation for verification of azoospermia after vasectomy in chimpanzees (Pan troglodytes). (17877328)
2007
23
Testicular sperm extraction in cancerous testicle in patients with azoospermia: a case report. (17172283)
2007
24
Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. (16824523)
2006
25
Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. (16372124)
2006
26
Azoospermia: virtual reality or possible to quantify? (16598028)
2006
27
Vasal obstruction after hernioplasty: the importance of surgical strategy in preventing azoospermia. (16794407)
2006
28
Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (16884537)
2006
29
Immunophenotypical characterization of contractile cells in caput epididymidis of men affected by congenital or post-inflammatory obstructive azoospermia. (15734898)
2005
30
Constitutional mosaic trisomy 21 and azoospermia: a case report. (15719052)
2005
31
Chromosome abnormalities in spermatozoa of patients with azoospermia and normal somatic karyotype. (16192717)
2005
32
Sperm retrieval for intra-cytoplasmic sperm injection in non-obstructive azoospermia. (15951734)
2005
33
Meiotic studies of infertile men in case of non-obstructive azoospermia with normal karyotype and no microdeleted Y-chromosome precise the clinical couple management. (15183743)
2004
34
Outcome of testicular sperm recovery and ICSI in patients with non-obstructive azoospermia with a history of orchidopexy. (15310729)
2004
35
Yq microdeletions--azoospermia factor candidate genes and spermatogenic arrest. (15331583)
2004
36
New techniques for sperm acquisition in obstructive azoospermia. (15363724)
2004
37
Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (15081113)
2004
38
Genetic analysis of three polymorphic sites of the luteinizing hormone beta-subunit gene in infertile Korean men with nonobstructive azoospermia. (12620433)
2003
39
Spermatogonial proliferation patterns in men with azoospermia of different etiologies. (14607570)
2003
40
Absence of microdeletions in the azoospermia-factor region of the Y-chromosome in Viennese men seeking assisted reproduction. (14740346)
2003
41
Percutaneous epididymal sperm aspiration (PESA) in men with obstructive azoospermia. (15745497)
2003
42
Increased (CTG/CAG)(n) lengths in myotonic dystrophy type 1 and Machado-Joseph disease genes in idiopathic azoospermia patients. (12042281)
2002
43
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. (11994405)
2002
44
Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (12366783)
2002
45
Suppression of spermatogenesis to azoospermia by combined administration of GnRH antagonist and 19-nortestosterone cannot be maintained by this non-aromatizable androgen alone. (11726576)
2001
46
Absence of deleted in azoospermia (DAZ) genes in spermatozoa of infertile men with somatic DAZ deletions. (11239526)
2001
47
Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. (10376575)
1999
48
Absence of microdeletions in the Y chromosome in patients with a history of cryptorchidism and azoospermia or oligospermia. (10202881)
1999
49
Cystic fibrosis mutation screening in CBAVD patients and men with obstructive azoospermia or severe oligozoospermia. (9620832)
1998
50
The azoospermia factor (AZF) of the human Y chromosome in Yq11: function and analysis in spermatogenesis. (8711205)
1995

Variations for Azoospermia

About this section

Expression for genes affiliated with Azoospermia

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Azoospermia

Search GEO for disease gene expression data for Azoospermia.

Pathways for genes affiliated with Azoospermia

About this section

Compounds for genes affiliated with Azoospermia

About this section

GO Terms for genes affiliated with Azoospermia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.3DAZAP2, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
2nucleusGO:0056345.3RBMY1A1, DAZL, DAZAP2, DAZ1, DAZ4, DAZ2

Biological processes related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of translational initiationGO:0459489.4BOLL, DAZ1, DAZL
2RNA splicingGO:0083808.5RBMY1A1, RBMY1E, RBMY1D
3multicellular organismal developmentGO:0072758.4DAZL, DAZ1, DAZ4, DAZ2, DAZ3, BOLL
4mRNA processingGO:0063978.2RBMY1D, RBMY1E, RBMY1A1
5cell differentiationGO:0301548.0DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3, SOHLH1
6spermatogenesisGO:0072837.8BOLL, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Molecular functions related to Azoospermia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1translation activator activityGO:0084949.5BOLL, DAZ1, DAZL
2RNA bindingGO:0037236.3DAZL, DAZ1, DAZ4, DAZ2, DAZAP1, DAZ3
3nucleotide bindingGO:0001665.9RBMY1A1, DAZL, DAZ1, DAZ4, DAZ2, DAZAP1

Products for genes affiliated with Azoospermia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Azoospermia

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet