B-CLL
MCID: BCL009
MIFTS: 66

B-Cell Chronic Lymphocytic Leukemia (B-CLL) malady

Cancer diseases, Blood diseases, Rare diseases, Immune diseases categories

Summaries for B-Cell Chronic Lymphocytic Leukemia

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

MalaCards: B-Cell Chronic Lymphocytic Leukemia, also known as lymphoplasmacytic leukemia, is related to chronic lymphocytic leukemia and leukemia. An important gene associated with B-Cell Chronic Lymphocytic Leukemia is ATM (ataxia telangiectasia mutated), and among its related pathways are DNA Damage Induced 14-3-3Sigma Signaling and BARD1 signaling events. The drugs immunoglobulins, intravenous and cyclophosphamide and the compounds sulindac sulfide and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and bone marrow, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Description from OMIM:48 109543, 151400, 609630, 612557, 612558 612559 more

Aliases & Classifications for B-Cell Chronic Lymphocytic Leukemia

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Sources:
50Orphanet, 48OMIM, 63UMLS, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

50
b-cell chronic lymphocytic leukemia:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

b-cell chronic lymphocytic leukemia 50 48
lymphoplasmacytic leukemia 50 63
malignant lymphoma - lymphoplasmacytic 63
b-cell chronic lymphoid leukemia 50
lymphoplasmacytoid immunocytoma 50
chronic lymphocytic leukemia 63
small lymphocytic lymphoma 50
b-cll 50


External Ids:

MESH via Orphanet37 D015451
ICD10 via Orphanet27 C91.1
SNOMED-CT via Orphanet60 277473004, 51092000, 92814006 302841002, more
UMLS via Orphanet64 C0023434
ICD1026 C91.1

Related Diseases for B-Cell Chronic Lymphocytic Leukemia

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the B-Cell Chronic Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia Leukemia-1, T-Cell Acute Lymphocytic
Lymphocytic Leukemia, Acute T-Cell

Diseases related to B-Cell Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia32.5ATM, IGHM, CCND1, ZAP70, CD38
2leukemia32.5CD38, ZAP70, CCND1, TP53, ATM
3mantle cell lymphoma31.2ATM, CCND1
4b-cell lymphomas31.0ATM, IGHM, TP53, CCND1, ZAP70
5hodgkin's lymphoma30.9ZAP70, IGHM, ATM
6prolymphocytic leukemia30.5ATM, CCND1, ZAP70, CD38
7follicular lymphoma30.5ZAP70, CCND1, IGHM
8multiple myeloma30.4TP53, CCND1, CD38
9melanoma30.3ATM, TP53, CCND1, BAGE, ZAP70
10autoimmune hemolytic anemia10.7
11hemolytic anemia10.7
12non-hodgkin lymphoma10.6
13lymphoid leukemia10.6
14pure red-cell aplasia10.5
15herpes simplex10.5
16retinoblastoma10.5
17richter's syndrome10.4
18diffuse large b-cell lymphoma10.4
19adenocarcinoma10.4
20cll/sll10.4
21colon adenocarcinoma10.4
22hairy cell leukemia10.4
23hepatitis10.4
24myeloma10.4
25vasculitis10.4
26endotheliitis10.4
27postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
28pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
29macroglobulinemia10.3
30dendritic cell sarcoma10.3
31sarcoma10.3
32graft versus host disease10.3
33genital herpes10.3
34hepatitis c10.3
35polycythemia vera10.3
36membranoproliferative glomerulonephritis10.3
37pemphigus10.3
38hepatitis b10.3
39chronic myeloid leukemia10.3
40tonsillitis10.3
41mycosis fungoides10.3
42ataxia telangiectasia10.3
43cerebritis10.3
44granuloma annulare10.3
45merkel cell carcinoma10.3
46acute lymphocytic leukemia10.3
47aplastic anemia10.3
48arthritis10.3
49cervicitis10.3
50encephalitis10.3

Graphical network of the top 20 diseases related to B-Cell Chronic Lymphocytic Leukemia:



Diseases related to b-cell chronic lymphocytic leukemia

Symptoms for B-Cell Chronic Lymphocytic Leukemia

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Sources:
48OMIM
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Symptoms by clinical synopsis from OMIM:

109543

Clinical features from OMIM:

109543,151400,609630,612557,612558,612559

Drugs & Therapeutics for B-Cell Chronic Lymphocytic Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for B-Cell Chronic Lymphocytic Leukemia

Search NIH Clinical Center for B-Cell Chronic Lymphocytic Leukemia

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for B-Cell Chronic Lymphocytic Leukemia

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Anatomical Context for B-Cell Chronic Lymphocytic Leukemia

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34MalaCards
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MalaCards organs/tissues related to B-Cell Chronic Lymphocytic Leukemia:

34
B cells, Bone, Bone marrow, Lymph node, T cells, Endothelial, Colon, Kidney, Whole blood, Smooth muscle, Nk cells, Myeloid, Tonsil, Testes, Skin, Liver, Thyroid

Animal Models for B-Cell Chronic Lymphocytic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to B-Cell Chronic Lymphocytic Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.9CCND1, TP53, IGHG1, IGHM, ATM
2MP:00053979.7IGHM, IGHG1, TP53, CCND1, ZAP70, CD38
3MP:00053799.5ATM, IGHM, TP53, DHH, CCND1, CD38

Publications for B-Cell Chronic Lymphocytic Leukemia

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Sources:
53PubMed
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Articles related to B-Cell Chronic Lymphocytic Leukemia:

(show top 50)    (show all 600)
idTitleAuthorsYear
1
Concomitant JAK2 V617F-positive polycythemia vera and B-cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells. (23280542)
2013
2
High CD74 expression correlates with ZAP70 expression in B cell chronic lymphocytic leukemia patients. (23572149)
2013
3
KIR/HLA gene combinations influence susceptibility to B-cell chronic lymphocytic leukemia and the clinical course of disease. (21726204)
2011
4
Cutaneous manifestations of B-cell chronic lymphocytic leukemia associated with Borrelia burgdorferi infection showing a marginal zone B-cell lymphoma-like infiltrate. (21946761)
2011
5
SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target. (21844565)
2011
6
The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. (20428196)
2010
7
Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (18396212)
2008
8
Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. (18003886)
2008
9
Alemtuzumab in the treatment of fludarabine refractory B-cell chronic lymphocytic leukemia (CLL). (19707426)
2008
10
Massive swelling of the cervical region: an uncommon manifestation of B cell chronic lymphocytic leukemia. (18688662)
2008
11
Aberrant expression of T-cell-associated markers CD4 and CD7 on B-cell chronic lymphocytic leukemia. (17019687)
2007
12
Expression of soluble CD27 and interleukins-8 and -10 in B-cell chronic lymphocytic leukemia: correlation with disease stage and prognosis. (17526459)
2007
13
B-cell chronic lymphocytic leukemia-derived dendritic cells stimulate allogeneic T-cell response and express chemokines involved in T-cell migration. (17949237)
2007
14
IGHV3-21 gene expression in patients with B-cell chronic lymphocytic leukemia in Ukraine. (18004251)
2007
15
Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia. (17350468)
2007
16
Comparison of methods for determining zeta-chain associated protein - 70 (ZAP-70) expression in patients with B-cell chronic lymphocytic leukemia (B-CLL). (16906577)
2006
17
Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H. (16316778)
2006
18
Cytotoxic effect of R-etodolac (SDX-101) in combination with purine analogs or monoclonal antibodies on ex vivo B-cell chronic lymphocytic leukemia cells. (17169808)
2006
19
Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease. (16840194)
2006
20
Sequential fluorescence in situ hybridization analysis for trisomy 12 in B-cell chronic lymphocytic leukemia. (15998971)
2005
21
Hodgkin's disease in an elderly patient with B-cell chronic lymphocytic leukemia. (16276018)
2005
22
Detection of t(14;18)(q32;q21) in B-cell chronic lymphocytic leukemia. (15737042)
2005
23
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. (15068894)
2004
24
Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. (15370211)
2004
25
ATM mutations in B-cell chronic lymphocytic leukemia. (14754616)
2004
26
Clinical significance of soluble p53 protein in B-cell chronic lymphocytic leukemia. (15590397)
2004
27
Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies. (15231529)
2004
28
Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. (15075077)
2004
29
Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia. (14695629)
2004
30
Re: "anthropometric characteristics, physical activity, and risk of non-Hodgkin's lymphoma subtypes and B-cell chronic lymphocytic leukemia: a prospective study". (12851233)
2003
31
Peripheral blood CD38 expression predicts time to progression in B-cell chronic lymphocytic leukemia after first-line therapy with high-dose chlorambucil. (11836173)
2002
32
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. (11929788)
2002
33
Enhanced clearance of leukemic lymphocytes in B-cell chronic lymphocytic leukemia with etodolac. (11926185)
2002
34
Rheumatoid arthritis and B-cell chronic lymphocytic leukemia. (11892712)
2002
35
Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides. (11830482)
2002
36
Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia. (12040435)
2002
37
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. (11313271)
2001
38
Lack of allelic exclusion and isotype switching in B cell chronic lymphocytic leukemia. (11754422)
2001
39
Influence of abnormalities of TP53 and ATM genes for course of B-cell chronic lymphocytic leukemia]. (11875779)
2001
40
p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation. (11468183)
2001
41
The activation of intracellular tyrosine kinases by interferon-alpha (IFNalpha) correlates with its antiproliferative activity in B-lymphoid cell lines, but not in B-cell chronic lymphocytic leukemia patients. (10803933)
2000
42
Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax. (10025901)
1999
43
Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia. (10397742)
1999
44
p53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis. (9596683)
1998
45
A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5. (9599022)
1998
46
Incidence of 5' bcl-2 rearrangement in patients with B cell chronic lymphocytic leukemia from India. (8947590)
1996
47
Response to cyclosporin A and recombinant human erythropoietin in a case of B cell chronic lymphocytic leukemia and pure red cell aplasia. (8709652)
1996
48
Variable expression of CD49d antigen in B cell chronic lymphocytic leukemia is related to disease stages. (8709639)
1996
49
Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by fluorescence in situ hybridization. (7627948)
1995
50
Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs. (7949099)
1994

Variations for B-Cell Chronic Lymphocytic Leukemia

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Expression for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for B-Cell Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 61Thomson Reuters, 56Reactome, 31KEGG, 58SinoBiological, 13EMD Millipore
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Pathways related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TP53, ATM
210.3ATM, TP53
3
Show member pathways
10.3TP53, ATM
410.3TP53, ATM
5
Show member pathways
10.3ATM, TP53
610.3TP53, CCND1
7
Show member pathways
Cell cycle39
10.2CCND1, TP53, ATM
8
Show member pathways
10.2CCND1, TP53, ATM
9
Show member pathways
10.2CCND1, TP53, ATM
1010.2CCND1, TP53, ATM
11
Show member pathways
Signaling Pathways in Glioblastoma39
10.2CCND1, TP53, ATM
12
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
10.2CCND1, TP53, ATM
1310.2ATM, TP53, CCND1
1410.2ATM, TP53, CCND1
15
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
10.2ATM, TP53, CCND1
1610.2ATM, TP53, CCND1
17
Show member pathways
10.2ATM, TP53, CCND1
18
Show member pathways
DNA damage response39
10.2ATM, TP53, CCND1
1910.2ATM, TP53, CCND1
2010.2CCND1, POT1, ATM
21
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
10.2CCND1, TP53, IGHG1
2210.1TP53, CHST11, CCND1
23
Show member pathways
10.1CCND1, POT1, TP53, ATM
24
Show member pathways
10.0BTG1, CCND1, TP53, ATM
25
Show member pathways
9.9TP53, DHH, CCND1, ZAP70, ATM

Compounds for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank
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Compounds related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulindac sulfide4610.3CCND1, TP53
2fludarabine46 52 1212.2CD38, ZAP70, TP53
3bpde4610.2ATM, TP53
4adpribose4610.2CD38, CCND1, TP53
5olomoucine46 1211.0CCND1, TP53

GO Terms for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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17Gene Ontology
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Biological processes related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.4CCND1, TP53
2replicative senescenceGO:09039910.4TP53, ATM
3Leydig cell differentiationGO:03332710.2CCND1, DHH
4response to gamma radiationGO:01033210.2TRIM13, TP53
5response to X-rayGO:01016510.2TP53, CCND1
6cellular response to DNA damage stimulusGO:0069749.9CCND1, TP53, ATM

Products for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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  • Antibodies
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Sources for B-Cell Chronic Lymphocytic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet