B-CLL
MCID: BCL009
MIFTS: 59

B-Cell Chronic Lymphocytic Leukemia (B-CLL) malady

Cancer, Blood, Immune categories

Summaries for B-Cell Chronic Lymphocytic Leukemia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

MalaCards: B-Cell Chronic Lymphocytic Leukemia, also known as lymphoplasmacytic leukemia, is related to mantle cell lymphoma and follicular lymphoma. An important gene associated with B-Cell Chronic Lymphocytic Leukemia is ATM (ataxia telangiectasia mutated), and among its related pathways are Cyclins and Cell Cycle Regulation and p53 signaling pathway. The drugs mercaptopurine and chlorambucil and the compounds bpde and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone marrow and whole blood, and related mouse phenotype cellular.

Description from OMIM:47 109543, 151400, 609630, 612557, 612558 612559 more

Aliases & Classifications for B-Cell Chronic Lymphocytic Leukemia

Sources:
49Orphanet, 47OMIM, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
b-cell chronic lymphocytic leukemia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

b-cell chronic lymphocytic leukemia 49 47
lymphoplasmacytic leukemia 49 61
malignant lymphoma - lymphoplasmacytic 61
b-cell chronic lymphoid leukemia 49
lymphoplasmacytoid immunocytoma 49
chronic lymphocytic leukemia 61
small lymphocytic lymphoma 49
b-cll 49


External Ids:

MESH via Orphanet36 D015451
ICD10 via Orphanet26 C91.1
SNOMED-CT via Orphanet58 277473004, 51092000, 92814006
UMLS via Orphanet62 C0023434
ICD1025 C91.1

Related Diseases for B-Cell Chronic Lymphocytic Leukemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to B-Cell Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1mantle cell lymphoma31.1ATM, CCND1
2follicular lymphoma30.6CCND1, ZAP70, IGHM, CD5
3macroglobulinemia30.5CD5
4hypercalcemia30.4TRIM13
5b-cell lymphomas30.1CCND1, ZAP70, ATM, IGHM, CD5, TP53
6burkitt's lymphoma30.1CD38, IGHM, ZAP70
7asthma30.1ZAP70, CD38
8t-cell leukemia11.4
9leukemia, t-cell, chronic11.4
10leukemia, b-cell, chronic11.2
11leukemia, chronic lymphocytic 110.9
12leukemia/lymphoma, t-cell10.8
13plasma cell leukemia10.7
14richter's syndrome10.7
15autoimmune hemolytic anemia10.7
16lymphoid leukemia10.6
17familial chronic lymphocytic leukemia10.6
18acute myeloid leukemia10.5
19composite lymphoma10.5
20central nervous system leukemia10.5
21progressive multifocal leukoencephalopathy10.5
22essential thrombocythemia10.4
23leukemia, chronic lymphocytic 310.4
24hepatitis c10.4
25mast-cell leukemia10.4
26n syndrome10.4
27acute leukemia10.4
28acute lymphocytic leukemia10.4
29adenocarcinoma10.4
30vasculitis10.4
31chronic myelomonocytic leukemia10.4
32lymphocytic vasculitis10.4
33leukemia, chronic lymphocytic 210.4
34lymphoma, diffuse large cell10.4
35postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
36pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
37squamous cell carcinoma10.4
38acute myelomonocytic leukemia10.4
39angiomatosis10.4
40leukemia, chronic lymphocytic 410.4
41small cell sarcoma10.3
42central nervous system lymphoma10.3
43nephritis10.3
44graft versus host disease10.3
45genital herpes10.3
46membranoproliferative glomerulonephritis10.3
47colon lymphoma10.3
48polycythemia vera10.3
49thyroid lymphoma10.3
50ataxia telangiectasia10.3

Graphical network of the top 20 diseases related to B-Cell Chronic Lymphocytic Leukemia:



Diseases related to b-cell chronic lymphocytic leukemia

Clinical Features for B-Cell Chronic Lymphocytic Leukemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

109543,151400,609630,612557,612558,612559

Clinical synopsis from OMIM:

109543

Drugs & Therapeutics for B-Cell Chronic Lymphocytic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for B-Cell Chronic Lymphocytic Leukemia

Search NIH Clinical Center for B-Cell Chronic Lymphocytic Leukemia

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for B-Cell Chronic Lymphocytic Leukemia

Anatomical Context for B-Cell Chronic Lymphocytic Leukemia

Sources:
33MalaCards
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MalaCards organs/tissues related to B-Cell Chronic Lymphocytic Leukemia:

33
Lymph node, Bone marrow, Whole blood, Smooth muscle, Prostate, T cells, B cells, Endothelial

Animal Models for B-Cell Chronic Lymphocytic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to B-Cell Chronic Lymphocytic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2TP53, CD38, CD5, POT1, IGHG1, IGHM

Publications for B-Cell Chronic Lymphocytic Leukemia

Sources:
51PubMed
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Articles related to B-Cell Chronic Lymphocytic Leukemia:

(show top 50)    (show all 169)
idTitleAuthorsYear
1
Enumeration of interleukin-10-positive B cells from peripheral blood of patients with chronic lymphocytic leukemia. (23998252)
2014
2
Regulatory T-cells in chronic lymphocytic leukemia: actor or innocent bystander? (23358515)
2013
3
The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells. (23850807)
2013
4
Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia. (23249221)
2013
5
Autologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter's syndrome): A retrospective analysis from the chronic lymphocytic leukemia subcommittee of the chronic leukemia working party and lymphoma working party of the European Group for Blood and Marrow Transplantation. (22547610)
2012
6
A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds I+4I^1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells. (22730324)
2012
7
Cutaneous manifestations of B-cell chronic lymphocytic leukemia associated with Borrelia burgdorferi infection showing a marginal zone B-cell lymphoma-like infiltrate. (21946761)
2011
8
TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation. (21908732)
2011
9
The autocrine motility factor receptor is overexpressed on the surface of B cells in Binet C chronic lymphocytic leukemia. (20574759)
2011
10
Cross-talk between chronic lymphocytic leukemia cells and bone marrow endothelial cells: role of signal transducer and activator of transcription 3. (21733558)
2011
11
Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells. (21519633)
2011
12
Concurrent classical Hodgkin lymphoma and plasmablastic lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma treated with fludarabine: a dimorphic presentation of iatrogenic immunodeficiency-associated lymphoproliferative disorder with evidence suggestive of multiclonal transformability of B cells by Epstein-Barr virus. (20869749)
2010
13
Prognostic value of the bone marrow microvessel density in progressive B-cell chronic lymphocytic leukemia. (20496991)
2010
14
High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. (19762537)
2009
15
Epstein-Barr virus-positive lymphoma after alemtuzumab therapy for B-cell chronic lymphocytic leukemia. (19330655)
2009
16
Increased serum BAFF (B-cell activating factor of the TNF family) level is a peculiar feature associated with familial chronic lymphocytic leukemia. (18556064)
2009
17
A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display. (19667400)
2009
18
The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells. (18492692)
2008
19
Combined molecular biological and molecular cytogenetic analysis of genomic changes in 146 patients with B-cell chronic lymphocytic leukemia. (18665750)
2008
20
BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. (18596739)
2008
21
Concomitant Herpes simplex and Epstein-Barr virus lymphadenitis with simultaneous lymph node metastases of an occult squamous cell carcinoma in a patient with chronic lymphocytic leukemia. (19052994)
2008
22
Lipoprotein lipase mRNA expression in whole blood is a prognostic marker in B cell chronic lymphocytic leukemia. (17158192)
2007
23
B-cell chronic lymphocytic leukemia: clinical impact of biological prognostic factors and updated treatment strategies. (18959056)
2007
24
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. (17179226)
2007
25
Metaphase cells with normal G-bands have cryptic interstitial deletions in 13q14 detectable by fluorescence in situ hybridization in B-cell chronic lymphocytic leukemia. (16631472)
2006
26
Phase II study of single-agent bortezomib for the treatment of patients with fludarabine-refractory B-cell chronic lymphocytic leukemia. (16832816)
2006
27
Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia. (15661260)
2005
28
Early B-cell chronic lymphocytic leukemia presenting as cutaneous lesions with a normal peripheral blood lymphocyte count. (16112376)
2005
29
A gender-based score system predicts the clinical outcome of patients with early B-cell chronic lymphocytic leukemia. (16032778)
2005
30
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha. (15860672)
2005
31
Allogeneic dendritic cells pulsed with tumor lysates or apoptotic bodies as immunotherapy for patients with early-stage B-cell chronic lymphocytic leukemia. (15990861)
2005
32
Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL). (15467427)
2004
33
Guillain-BarrAc syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia. (15359655)
2004
34
Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells. (12718765)
2003
35
Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. (12886250)
2003
36
Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia. (12835741)
2003
37
Differential expression of alpha-smooth muscle actin molecule in a subset of bone marrow stromal cells, in b-cell chronic lymphocytic leukemia, autoimmune disorders and normal fetuses. (11874079)
2001
38
Higher levels of surface CD20 expression on circulating lymphocytes compared with bone marrow and lymph nodes in B-cell chronic lymphocytic leukemia. (11554173)
2001
39
Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. (11023495)
2000
40
Role of beta2 integrins in the prevention of apoptosis induction in chronic lymphocytic leukemia B cells. (10637474)
2000
41
Autoimmune hemolytic anemia in a patient with chronic lymphocytic leukemia and renal cell carcinoma after treatment with high-dose intravenous bolus interleukin-2. (10916762)
2000
42
B-cell chronic lymphocytic leukemia: a bird of a different feather. (10458259)
1999
43
Revealing some oncofetal antigens in peripheral blood mononuclear cells of donors and patients with B-chronic lymphocytic leukemia. (9783803)
1998
44
Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma. (9583687)
1998
45
Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis. (9009090)
1997
46
Characterization and sensitivity to interleukin 2 and interferon alpha of leukemic cells from a patient with large granular lymphocytic leukemia associated with chronic active Epstein-Barr virus infection. (9403005)
1997
47
Chronic lymphocytic leukemia B cells are resistant to the apoptotic effects of transforming growth factor-beta. (9028325)
1997
48
Increased intracellular and plasma levels of basic fibroblast growth factor in B-cell chronic lymphocytic leukemia. (7772131)
1995
49
Cytokine gene expression in B-cell chronic lymphocytic leukemia: evidence of constitutive interleukin-8 (IL-8) mRNA expression and secretion of biologically active IL-8 protein. (7517209)
1994
50
Regulatory mechanisms for the expression of a functional beta chain of interleukin 2 receptor on T4 chronic lymphocytic leukemia cells. (1764265)
1991

Genetic Variations for B-Cell Chronic Lymphocytic Leukemia

Expression for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for B-Cell Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Sources:
45Novoseek, 11DrugBank
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Compounds related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bpde4510.6TP53, ATM
2fludarabine45 1111.6TP53, CD38, ZAP70
3adpribose4510.4TP53, CD38, CCND1

GO Terms for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Sources:
16Gene Ontology
See all sources

Biological processes related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.6TP53, CCND1
2response to X-rayGO:01016510.6TP53, CCND1
3replicative senescenceGO:09039910.5TP53, ATM
4Leydig cell differentiationGO:03332710.3DHH, CCND1

Products for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources for B-Cell Chronic Lymphocytic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet