B-CLL
MCID: BCL009
MIFTS: 54

B-Cell Chronic Lymphocytic Leukemia (B-CLL) malady

Cancer diseases, Blood diseases, Immune diseases categories

Summaries for B-Cell Chronic Lymphocytic Leukemia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 B-cell chronic lymphocytic leukemia (B-CLL), also known as chronic lymphoid leukemia (CLL), is the most... more...

MalaCards: B-Cell Chronic Lymphocytic Leukemia, also known as lymphoplasmacytic leukemia, is related to chronic lymphocytic leukemia and leukemia. An important gene associated with B-Cell Chronic Lymphocytic Leukemia is ATM (ataxia telangiectasia mutated), and among its related pathways are Cyclins and Cell Cycle Regulation and p53 signaling pathway. The drugs mercaptopurine and chlorambucil and the compounds bpde and fludarabine have been mentioned in the context of this disorder. Affiliated tissues include b cells, bone marrow and bone, and related mouse phenotype cellular.

Description from OMIM:46 109543, 151400, 609630, 612557, 612558 612559 more

Aliases & Classifications for B-Cell Chronic Lymphocytic Leukemia

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48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
b-cell chronic lymphocytic leukemia:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Adulthood


Aliases & Descriptions:

b-cell chronic lymphocytic leukemia 48 46
lymphoplasmacytic leukemia 48 60
malignant lymphoma - lymphoplasmacytic 60
b-cell chronic lymphoid leukemia 48
lymphoplasmacytoid immunocytoma 48
chronic lymphocytic leukemia 60
small lymphocytic lymphoma 48
b-cll 48


External Ids:

MESH via Orphanet35 D015451
ICD10 via Orphanet26 C91.1
SNOMED-CT via Orphanet57 277473004, 51092000, 92814006 302841002, more
UMLS via Orphanet61 C0023434
ICD1025 C91.1

Related Diseases for B-Cell Chronic Lymphocytic Leukemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the B-Cell Chronic Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia Leukemia-1, T-Cell Acute Lymphocytic
Lymphocytic Leukemia, Acute T-Cell

Diseases related to B-Cell Chronic Lymphocytic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1chronic lymphocytic leukemia32.5CCND1, ZAP70, ATM, IGHM, CD5, CD38
2leukemia32.5TP53, CCND1, ZAP70, ATM, CD5, CD38
3mantle cell lymphoma31.0ATM, CCND1
4non-hodgkin lymphoma30.8CCND1, ATM, CD5, CD38
5myeloma30.6CD38, IGHM, CCND1
6macroglobulinemia30.4CD5
7hypercalcemia30.4TRIM13
8prolymphocytic leukemia30.4CCND1, ZAP70, ATM, CD5, CD38
9multiple myeloma30.4TP53, CD38, CCND1
10severe combined immunodeficiency30.1CD38, ZAP70
11burkitt's lymphoma30.1CD38, IGHM, ZAP70
12t-cell leukemia10.9
13autoimmune hemolytic anemia10.6
14hemolytic anemia10.6
15lymphoid leukemia10.6
16b cell deficiency10.6
17pure red-cell aplasia10.5
18herpes simplex10.5
19hodgkin's lymphoma10.5
20retinoblastoma10.5
21acute myeloid leukemia10.5
22composite lymphoma10.5
23central nervous system leukemia10.5
24progressive multifocal leukoencephalopathy10.5
25chronic monocytic leukemia10.4
26monocytic leukemia10.4
27richter's syndrome10.4
28mast-cell leukemia10.4
29hepatitis b10.4
30diffuse large b-cell lymphoma10.4
31acute leukemia10.4
32acute lymphocytic leukemia10.4
33adenocarcinoma10.4
34cll/sll10.4
35colon adenocarcinoma10.4
36hairy cell leukemia10.4
37hepatitis10.4
38vasculitis10.4
39postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
40pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma10.4
41squamous cell carcinoma10.4
42small cell sarcoma10.3
43dendritic cell sarcoma10.3
44sarcoma10.3
45gaucher's disease10.3
46central nervous system lymphoma10.3
47purpura10.3
48graft versus host disease10.3
49genital herpes10.3
50membranoproliferative glomerulonephritis10.3

Graphical network of the top 20 diseases related to B-Cell Chronic Lymphocytic Leukemia:



Diseases related to b-cell chronic lymphocytic leukemia

Clinical Features for B-Cell Chronic Lymphocytic Leukemia

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Sources:
46OMIM
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Clinical features from OMIM:

109543,151400,609630,612557,612558,612559

Clinical synopsis from OMIM:

109543

Drugs & Therapeutics for B-Cell Chronic Lymphocytic Leukemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Drug clinical trials:

Search ClinicalTrials for B-Cell Chronic Lymphocytic Leukemia

Search NIH Clinical Center for B-Cell Chronic Lymphocytic Leukemia

Search CenterWatch for B-Cell Chronic Lymphocytic Leukemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for B-Cell Chronic Lymphocytic Leukemia

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Anatomical Context for B-Cell Chronic Lymphocytic Leukemia

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32MalaCards
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MalaCards organs/tissues related to B-Cell Chronic Lymphocytic Leukemia:

32
B cells, Bone marrow, Bone, Lymph node

Animal Models for B-Cell Chronic Lymphocytic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to B-Cell Chronic Lymphocytic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538411.2TP53, CD38, CD5, POT1, IGHG1, IGHM

Publications for B-Cell Chronic Lymphocytic Leukemia

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Genetic Variations for B-Cell Chronic Lymphocytic Leukemia

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Expression for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

Search GEO for disease gene expression data for B-Cell Chronic Lymphocytic Leukemia.

Pathways for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
44Novoseek, 11DrugBank
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Compounds related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bpde4410.6TP53, ATM
2fludarabine44 1111.6TP53, CD38, ZAP70
3adpribose4410.4TP53, CD38, CCND1

GO Terms for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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Sources:
16Gene Ontology
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Biological processes related to B-Cell Chronic Lymphocytic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitotic G1 DNA damage checkpointGO:03157110.6TP53, CCND1
2response to X-rayGO:01016510.6TP53, CCND1
3replicative senescenceGO:09039910.5TP53, ATM
4Leydig cell differentiationGO:03332710.3DHH, CCND1

Products for genes affiliated with B-Cell Chronic Lymphocytic Leukemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for B-Cell Chronic Lymphocytic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet