MCID: BCL002
MIFTS: 49

B Cell Deficiency malady

Categories: Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for B Cell Deficiency

Aliases & Descriptions for B Cell Deficiency:

Name: B Cell Deficiency 12 14
Immunoglobulin Heavy Chain Deficiency 12 56 69
Immunoglobulin Heavy Chain Deletion 12
B Cell Deficiencies 12
Humoral Immune Defect 69

Classifications:

Orphanet: 56  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:2115
ICD9CM 35 279.03
SNOMED-CT 64 190982008
Orphanet 56 ORPHA169110
UMLS via Orphanet 70 C0398692
ICD10 via Orphanet 34 D80.8
UMLS 69 C0154276

Summaries for B Cell Deficiency

Disease Ontology : 12 A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.

MalaCards based summary : B Cell Deficiency, also known as immunoglobulin heavy chain deficiency, is related to arteriosclerosis and agammaglobulinemia. An important gene associated with B Cell Deficiency is IGLL1 (Immunoglobulin Lambda Like Polypeptide 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Selenium and Iron have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and nk cells, and related phenotypes are hematopoietic system and cellular

Related Diseases for B Cell Deficiency

Diseases related to B Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
id Related Disease Score Top Affiliating Genes
1 arteriosclerosis 29.3 BTK CD19 CD40LG CD79A
2 agammaglobulinemia 11.1
3 agammaglobulinemia, x-linked 1 10.7
4 lambda 5 deficiency 10.7
5 immunoglobulin alpha deficiency 10.7
6 b cell linker protein deficiency 10.7
7 autoimmune lymphoproliferative syndrome, type iii 10.7
8 alcoholic neuropathy 10.3 CD40LG CD79A
9 camptodactyly vertebral fusion 10.3 CD40LG CD79A
10 primary melanoma of the central nervous system 10.3 TNFRSF13B TNFRSF13C
11 spinal polio 10.3 CD40LG CD79A
12 rabies 10.3 CD40LG CD79A
13 unilateral retinoblastoma 10.3 CD40LG CD79A
14 mesangial proliferative glomerulonephritis 10.3 CD40LG CD79A
15 delta chain disease 10.3 CD40LG CD79A
16 discitis 10.3 CD40LG CD79A
17 spinal canal and spinal cord meningioma 10.3 CD40LG CD79A
18 trichostrongyloidiasis 10.3 CD40LG CD79A
19 heart septal defect 10.3 CD40LG CD79A
20 cutaneous polyarteritis nodosa 10.3 CD40LG CD79A
21 pediatric meningioma 10.3 CD40LG CD79A
22 tonsil cancer 10.2 CD40LG CD79A
23 indomethacin antenatal infection 10.2 CD40LG CD79A
24 diabetic angiopathy 10.2 BTK CD40LG CD79A
25 beach ear 10.2 CD40LG CD79A
26 acute kidney tubular necrosis 10.2 CD40LG CD79A
27 eye disease 10.2 CD27 CD79A
28 pancreatic serous cystadenoma 10.2 CD40LG CD79A CR2
29 atheroembolism of kidney 10.2 CD40LG CD79A
30 hyperparathyroidism, primary, caused by water clear cell hyperplasia 10.2 CD40 CD40LG
31 pyridoxine-responsive sideroblastic anemia 10.2 CD79A TGM2
32 partial sensory epilepsy 10.2 CD40LG CD79A
33 gestational diabetes 10.2 CD40LG CD79A SH2D1A
34 ritscher-schinzel syndrome 1 10.2 CD40LG CD79A
35 childhood pleomorphic rhabdomyosarcoma 10.1 CD19 CD40LG CD79A
36 akinetopsia 10.1 CD19 CD40LG CD79A
37 ethmoid sinus schneiderian papilloma 10.1 CD19 CD40LG CD79A
38 colonic benign neoplasm 10.1 CD27 CD40LG CD79A
39 endocarditis 10.1 CD40LG CD79A
40 muscular dystrophy 10.1 CD40LG CD79A
41 cutaneous solitary mastocytoma 10.1 CD79A TGM2
42 bursitis 10.1 CD40 CD40LG CD79A
43 immunoglobulin beta deficiency 10.1 CD40 CD40LG CD79A
44 odontogenic myxoma 10.1 CD40LG CD79A TLR9
45 pedophilia 10.1 CD40LG CD79A TLR9
46 amyotrophic lateral sclerosis type 10 10.1 CD79A TGM2
47 hypogonadotropic hypogonadism 2 with or without anosmia 10.1 CD40LG CR2 SH2D1A
48 temtamy syndrome 10.1 CD40 CD40LG CD79A
49 ciliary body spindle cell melanoma 10.1 BTK CD40LG CD79A SH2D1A
50 ovarian cystic teratoma 10.1 CD40LG CD79A TLR9

Graphical network of the top 20 diseases related to B Cell Deficiency:



Diseases related to B Cell Deficiency

Symptoms & Phenotypes for B Cell Deficiency

MGI Mouse Phenotypes related to B Cell Deficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.2 CD8A CR2 NFKB2 PRKCD SH2D1A TGM2
2 cellular MP:0005384 10.11 CD8A IDS NFKB2 PRKCD TGM2 TLR9
3 homeostasis/metabolism MP:0005376 10.07 TGM2 TLR9 TNFRSF13B TNFRSF13C BTK CD19
4 immune system MP:0005387 10.06 BTK CD19 CD27 CD40 CD40LG CD79A
5 mortality/aging MP:0010768 9.7 BTK CD19 CD40LG CD8A CR2 IDS
6 renal/urinary system MP:0005367 9.32 CD19 CD40 CD40LG CD79A CR2 NFKB2

Drugs & Therapeutics for B Cell Deficiency

Drugs for B Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 524)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4 7782-49-2
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
3
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
4
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
5
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1 36791-04-5 37542
6
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
8
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1 69655-05-6 50599
9
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 154598-52-4 64139
10
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 134678-17-4 60825
11
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
12
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
13
Methotrexate Approved Phase 4,Phase 3,Phase 2 1959-05-2, 59-05-2 126941
14
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
15
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
16
Nevirapine Approved Phase 4,Phase 3,Phase 2 129618-40-2 4463
17
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 143491-57-0 60877
18
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147127-20-6 464205
19
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 376348-65-1 3002977
20 Dolutegravir Approved Phase 4,Phase 3,Phase 2 1051375-16-6 54726191
21
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
22
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
23
Lopinavir Approved Phase 4,Phase 3,Phase 2 192725-17-0 92727
24
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
25
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2 3056-17-5 18283
26
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1 30516-87-1 35370
27
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
28
Cysteamine Approved, Investigational Phase 4 60-23-1 6058
29
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2 136470-78-5 65140 441300
30
Peginterferon alfa-2b Approved Phase 4,Phase 3,Phase 1,Phase 2 99210-65-8, 215647-85-1
31
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1 635728-49-3, 206361-99-1 213039
32
Drospirenone Approved Phase 4 67392-87-4 68873
33
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
34
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
35
Enfuvirtide Approved, Investigational Phase 4,Phase 3,Phase 1 159519-65-0 16130199
36
Ethambutol Approved Phase 4,Phase 2,Phase 3 74-55-5 3279 14052
37
Isoniazid Approved Phase 4,Phase 2,Phase 3 54-85-3 3767
38
Pyrazinamide Approved Phase 4 98-96-4 1046
39
Rifampin Approved Phase 4,Phase 2,Phase 3 13292-46-1 5458213 5381226
40
Tipranavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 174484-41-4 65027
41
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 198153-51-4 5360545
42
Amprenavir Approved Phase 4,Phase 2 161814-49-9 65016
43
Indinavir Approved Phase 4,Phase 3,Phase 2 150378-17-9 5362440
44
Nelfinavir Approved Phase 4,Phase 3,Phase 2 159989-64-7 64143
45
Saquinavir Approved, Investigational Phase 4,Phase 3,Phase 2 127779-20-8 60787
46
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 5460373 44475014
47
Cobicistat Approved Phase 4,Phase 3,Phase 2 1004316-88-4
48
Nitric Oxide Approved Phase 4,Phase 2 10102-43-9 145068
49
Etravirine Approved Phase 4,Phase 2,Phase 3 269055-15-4 193962
50
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 50-14-6 5280793

Interventional clinical trials:

(show top 50) (show all 666)
id Name Status NCT ID Phase
1 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
2 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4
3 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4
4 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4
5 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4
6 Immunologic Action of a Single Dose Cholecalciferol Completed NCT01845142 Phase 4
7 LINFOTARGAM: Treatment With Chemotherapy Plus Rituximab and Highly Active Antiretroviral Therapy in Patients With Diffuse Large B Cell Lymphoma and Infection With the Human Immunodeficiency Virus (HIV) Completed NCT00466258 Phase 4
8 Immunologic Memory (Supp. of ATN 024) Completed NCT00142753 Phase 4
9 Immunogenicity and Safety of Trivalent Influenza Vaccine in Non-pregnant HIV-infected Women Completed NCT01812980 Phase 4
10 PI or NNRTI as First-line Treatment of HIV in West Africa - the PIONA Trial Completed NCT01192035 Phase 4
11 Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis Completed NCT00028262 Phase 4
12 A Simplification Study of Unboosted Reyataz With Epzicom (ASSURE) Completed NCT01102972 Phase 4
13 Induction and Expansion of T Cell Repertoire Using Growth Hormone and Vaccination in HIV-1 Infected Patients Completed NCT00287677 Phase 4
14 Interferon Alfa Sensitivity in HIV/HCV Persons Before and After HIV Meds Completed NCT01285050 Phase 4
15 A Research Study to See if a Change in Therapy for HIV Infection Can Improve the Immune Response to Treatment Completed NCT00145795 Phase 4
16 Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa Completed NCT02028676 Phase 4
17 Virological and Clinical Anti-Hepatitis B Virus (HBV) Efficacy of Tenofovir and Emtricitabine in Patients With HIV/HBV co-Infection Completed NCT00127959 Phase 4
18 An Immunologic Study of Treatment-Naive HIV Patients Starting a Darunavir/Ritonavir- or Efavirenz-Based HAART Completed NCT01541085 Phase 4
19 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4
20 A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy Completed NCT00344760 Phase 4
21 Compare the Efficacy and Safety of Raltegravir Versus Efavirenz Combination Therapy in Treatment-naïve HIV-1 Patients Completed NCT01989910 Phase 4
22 Efficacy of Influenza Vaccine in HIV Infected Adults Completed NCT00757900 Phase 4
23 REMEMBER: Reducing Early Mortality & Morbidity by Empiric Tuberculosis (TB) Treatment Completed NCT01380080 Phase 4
24 Once-daily Antiretroviral Therapy in HIV-1 Infected Patients With CD4+ Cell Counts Below 100 Cells/Mcl Completed NCT00532168 Phase 4
25 A Pilot Project of Virologic, Pharmacologic and Immunologic Correlates of Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution Following Maraviroc Therapy Completed NCT00870363 Phase 4
26 Maraviroc as an Immunomodulatory Drug for Antiretroviral-treated HIV Infected Patients Exhibiting Immunologic Failure Completed NCT00735072 Phase 4
27 Evaluation of 2 Interferon γ Assays in the Diagnosis of Latent Tuberculosis in HIV-infected Patients.ANRS EP 40 QUANTI SPOT Completed NCT00647205 Phase 4
28 Viral Kinetics of Treatment With Peginterferon Alpha-2a, Ribavirin and Epoetin β in Patients Coinfected HCV/HIV Completed NCT00356486 Phase 4
29 HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001) Completed NCT00192660 Phase 4
30 Antiretroviral Therapy for Advanced HIV Disease in South Africa Completed NCT00342355 Phase 4
31 KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects Completed NCT00549198 Phase 4
32 Anti-Retrovirals for Kaposi's Sarcoma Completed NCT00444379 Phase 4
33 FOTO: Five Consecutive Days on Treatment With Efavirenz, Tenofovir, and Emtricitabine Followed by Two Days Off Treatment Versus Continuous Treatment Completed NCT00414635 Phase 4
34 Once a Day (QD) - Twice a Day (BID) Clinical Trial: Didanosine, Lamivudine and Efavirenz Versus Zidovudine, Lamivudine and Efavirenz in the Starting Treatment of HIV Completed NCT00256828 Phase 4
35 DART II - A Phase IV Study of 3 Antiretroviral Medicines in Combination, in HIV Patients Who Have Not Been Previously Treated With Antiretroviral Therapy Completed NCT00116116 Phase 4
36 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
37 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Recruiting NCT02031289 Phase 4
38 Integrase and Maraviroc Intensification for Neurocognitive Dysfunction (InMIND) Recruiting NCT02519777 Phase 4
39 Evaluation of Safety and Immunogenicity of a Human Papillomavirus (HPV) Vaccine in Human Immunodeficiency Virus (HIV) Infected Females Active, not recruiting NCT01031069 Phase 4
40 Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients Active, not recruiting NCT03041051 Phase 4
41 The Dolutegravir Antiretroviral Mono-Therapy for HIV Trial Active, not recruiting NCT02401828 Phase 4
42 Elvitegravir/Cobicistat/Tenofovir DF/Emtricitabine With Darunavir Treatment Simplification Strategy Active, not recruiting NCT02199613 Phase 4
43 Hepatic Safety of Raltegravir Versus Efavirenz as HIV Therapy for Patients With HIV and HCV Coinfection Active, not recruiting NCT01147107 Phase 4
44 Optimization of Antiretroviral Therapy Not yet recruiting NCT02935075 Phase 4
45 Immune Reconstitution of Lopinavir/Ritonavir-Based vs Efavirenz-based HAART in Advanced HIV Disease Terminated NCT00775606 Phase 4
46 N-Acetylcysteine and Arginine Administration in Diabetic Patients Terminated NCT00569465 Phase 4
47 Evaluation of 3TC or FTC Mono-therapy Compared to Continuing HAART as a Bridging Strategy Terminated NCT01338025 Phase 4
48 Influence of Atorvastatin on Viral Replication During Antiretroviral Treatment Interruption Terminated NCT00355251 Phase 4
49 Immune Reconstitution in naïve HIV Patients With CD4 <100 Cells/mL When Treated With Lopinavir or Efavirenz. Terminated NCT00386659 Phase 4
50 A Study to Determine the Best Dose of Antivirals in Patients With Both TB and HIV Terminated NCT00523458 Phase 4

Search NIH Clinical Center for B Cell Deficiency

Genetic Tests for B Cell Deficiency

Anatomical Context for B Cell Deficiency

MalaCards organs/tissues related to B Cell Deficiency:

39
B Cells, T Cells, Nk Cells, Lung, Thyroid

Publications for B Cell Deficiency

Articles related to B Cell Deficiency:

(show top 50) (show all 52)
id Title Authors Year
1
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. ( 27303042 )
2016
2
Progressive severe B cell deficiency in pediatric Rubinstein-Taybi syndrome. ( 27825976 )
2016
3
Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. ( 25237204 )
2014
4
NK and B cell deficiency in a MPS type II family with novel mutation in the IDS gene. ( 25038527 )
2014
5
Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency. ( 25437445 )
2014
6
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. ( 25270508 )
2014
7
A case of IgM deficiency with B cell deficiency detected by ABO discrepancy in a patient with acute osteomyelitis. ( 23667850 )
2013
8
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C I'. ( 23319571 )
2013
9
Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency. ( 24069355 )
2013
10
B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia. ( 23991203 )
2013
11
T and B cell deficiency associated with yellow nail syndrome. ( 21995335 )
2012
12
Chronic B cell deficiency from birth prevents age-related alterations in the B lineage. ( 21810615 )
2011
13
More on NK-cell and B-cell deficiency with a thymic mass. ( 21591963 )
2011
14
NK-cell and B-cell deficiency with a thymic mass. ( 21306273 )
2011
15
Long-term immune deficiency after allogeneic stem cell transplantation: B-cell deficiency is associated with late infections. ( 20133894 )
2010
16
B cell-deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis. ( 16446379 )
2006
17
Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury. ( 15888022 )
2005
18
Mucosal B cell deficiency in IgA-/- mice abrogates the development of allergic lung inflammation. ( 16002732 )
2005
19
B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit mice. ( 14662329 )
2003
20
B cell deficiency confers protection from renal ischemia reperfusion injury. ( 12960350 )
2003
21
B-cell deficiency and type 1 diabetes. ( 11844863 )
2002
22
Successful immunosuppressive therapy with cyclosporine A for posthepatitis B-cell deficiency with activated cytoplasmic interferon--gamma-positive T-lymphocytes. ( 11999357 )
2002
23
Novel Igalpha (CD79a) gene mutation in a Turkish patient with B cell- deficient agammaglobulinemia. ( 11920841 )
2002
24
B-cell deficiency and type 1 diabetes. ( 11858222 )
2002
25
A case of severe B cell deficiency after allogeneic stem cell transplantation. ( 12235525 )
2002
26
B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. ( 11598082 )
2001
27
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. ( 11591325 )
2001
28
A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. ( 11003386 )
2000
29
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. ( 11104803 )
2000
30
B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. ( 10992465 )
2000
31
Microphthalmic mice display a B cell deficiency similar to that seen for mast and NK cells. ( 10586063 )
1999
32
Resistance to herpetic stromal keratitis in immunized B-cell-deficient mice. ( 10208930 )
1999
33
Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. ( 10030835 )
1999
34
B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization. ( 9794370 )
1998
35
Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. ( 9419212 )
1998
36
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. ( 9642684 )
1998
37
The effect of B cell deficiency on the immune response to acetylcholine receptor and the development of experimental autoimmune myasthenia gravis. ( 9646836 )
1998
38
Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. ( 9736610 )
1998
39
Analysis of T cell receptor V beta gene expression in B cell deficient mice after experimental herpes simplex virus keratitis. ( 9385402 )
1997
40
B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene. ( 9451590 )
1997
41
Alloantibody- and T cell-mediated immunity in the pathogenesis of transplant arteriosclerosis: lack of progression to sclerotic lesions in B cell-deficient mice. ( 9415552 )
1997
42
B cell-deficient muMT mice as an experimental model for Mycoplasma infections in X-linked agammaglobulinemia. ( 9295053 )
1997
43
A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat. ( 9164980 )
1997
44
Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice. ( 8816417 )
1996
45
The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. ( 7835973 )
1994
46
The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. ( 8157969 )
1994
47
Intestinal intraepithelial gamma/delta T cells in B-cell deficiency. ( 8167738 )
1993
48
B cell deficiency progresses with lineage maturation in nude.X-linked immunodeficient mice B cell deficiency progresses with lineage maturation. ( 1385525 )
1992
49
Chronic giardiasis in B-cell-deficient mice expressing the xid gene. ( 3262587 )
1988
50
Experimental model of B-cell deficiency in mice. ( 6966610 )
1980

Variations for B Cell Deficiency

Expression for B Cell Deficiency

Search GEO for disease gene expression data for B Cell Deficiency.

Pathways for B Cell Deficiency

Pathways related to B Cell Deficiency according to GeneCards Suite gene sharing:

(show all 30)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 BTK CD19 CD27 CD40 CD40LG CD79A
2
Show member pathways
13.36 BTK CD19 CD40 CD40LG CD79A CD8A
3
Show member pathways
13.27 CD27 CD40 CD40LG NFKB2 PRKCD TNFRSF13B
4
Show member pathways
13.27 BTK CD27 CD40 CD40LG PRKCD TLR9
5
Show member pathways
13.19 BTK CD27 CD40 CD40LG PRKCD TNFRSF13B
6
Show member pathways
13.07 BTK CD19 CD40 CD79A CR2 PRKCD
7
Show member pathways
12.77 CD40 CD40LG CD8A TNFRSF13B TNFRSF13C
8
Show member pathways
12.59 CD40 CD40LG NFKB2 PRKCD TLR9 TNFRSF13C
9
Show member pathways
12.55 CD27 CD40 CD40LG CR2 PRKCD
10
Show member pathways
12.53 BTK CD40 CD40LG CD79A NFKB2
11
Show member pathways
12.48 BTK CD19 CD79A CR2 NFKB2
12
Show member pathways
12.45 BTK CD27 CD40 CD40LG PRKCD TLR9
13 12.35 BTK CD19 CD40LG CD79A CD8A NFKB2
14
Show member pathways
12.29 CR2 NFKB2 TNFRSF13B TNFRSF13C
15
Show member pathways
12.28 BTK CD19 CD79A CR2 PRKCD
16
Show member pathways
12.24 BTK CD19 CD40 PRKCD
17 12.21 CD19 CD40 CR2 NFKB2
18 11.96 CD19 CD40 CD40LG CD8A SH2D1A
19 11.89 CD19 CD79A CD8A
20
Show member pathways
11.84 BTK CD19 CD79A
21 11.8 CD19 CD8A CR2
22 11.78 BTK CD40 CD40LG NFKB2 TNFRSF13C
23
Show member pathways
11.7 CD27 CD40 CD40LG TNFRSF13B TNFRSF13C
24 11.68 CD19 CD8A TLR9
25
Show member pathways
11.64 CD40 CD40LG NFKB2 TNFRSF13B
26 11.55 CD27 CD40 CD40LG
27 11.48 CD40 CD40LG CR2 TLR9 TNFRSF13B TNFRSF13C
28 11.43 CD40 CD40LG TLR9
29 11.16 CD19 CD27 CD40 CD40LG CR2 TNFRSF13B
30 10.84 BTK CD19 CD40 CD40LG CD79A CD8A

GO Terms for B Cell Deficiency

Cellular components related to B Cell Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 BTK CD19 CD27 CD40 CD40LG CD79A
2 integral component of plasma membrane GO:0005887 9.7 CD19 CD27 CD40 CD40LG CD79A CD8A
3 external side of plasma membrane GO:0009897 9.28 CD19 CD27 CD40 CD40LG CD79A CD8A

Biological processes related to B Cell Deficiency according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.95 BTK CR2 IGLL1 NFKB2 SH2D1A TLR9
2 inflammatory response GO:0006954 9.93 CD27 CD40 CD40LG NFKB2 TLR9
3 immune response GO:0006955 9.93 CD27 CD40 CD40LG CD8A CR2 IGLL1
4 cell surface receptor signaling pathway GO:0007166 9.89 CD19 CD27 CD79A CD8A TNFRSF13B
5 platelet activation GO:0030168 9.77 CD40 CD40LG PRKCD
6 adaptive immune response GO:0002250 9.77 BTK CD79A SH2D1A TNFRSF13B TNFRSF13C
7 B cell differentiation GO:0030183 9.72 CD40LG CD79A CR2
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.72 BTK CD40 CD40LG NFKB2 TLR9
9 B cell receptor signaling pathway GO:0050853 9.71 BTK CD19 CD79A IGLL1
10 B cell activation GO:0042113 9.69 BTK CD40 CD79A
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.65 CD27 CD40 CD40LG TNFRSF13B TNFRSF13C
12 regulation of immune response GO:0050776 9.63 CD19 CD40 CD40LG CD8A SH2D1A TNFRSF13C
13 positive regulation of interleukin-12 production GO:0032735 9.61 CD40 CD40LG TLR9
14 negative regulation of B cell proliferation GO:0030889 9.59 BTK TNFRSF13B
15 positive regulation of endothelial cell apoptotic process GO:2000353 9.58 CD40 CD40LG
16 positive regulation of B cell differentiation GO:0045579 9.58 BTK CD27
17 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.57 TLR9 TNFRSF13C
18 immunoglobulin mediated immune response GO:0016064 9.56 CD27 PRKCD
19 regulation of immunoglobulin secretion GO:0051023 9.52 CD40 CD40LG
20 B cell proliferation GO:0042100 9.35 CD40 CD40LG CD79A CR2 PRKCD
21 immune system process GO:0002376 9.28 BTK CD40 CD79A CD8A CR2 SH2D1A

Molecular functions related to B Cell Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.92 CD27 CD79A CR2 TLR9

Sources for B Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....