MCID: BCL006
MIFTS: 47

B-Cell Lymphomas malady

Immune diseases category

Summaries for B-Cell Lymphomas

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32MalaCards
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MalaCards: B-Cell Lymphomas, also known as lymphoma, b-cell, is related to diffuse large b-cell lymphoma and gastric lymphoma. An important gene associated with B-Cell Lymphomas is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are Lymphocyte Signaling and Wnt signaling pathway. The drugs ibritumomab tiuxetan and rituximab and the compounds paraffin and vincristine have been mentioned in the context of this disorder. Affiliated tissues include b cells and bone, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for B-Cell Lymphomas

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Sources:
42NIH Rare Diseases, 46OMIM, 44Novoseek, 30LifeMap Discovery™, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

b-cell lymphomas 42 30 60
lymphoma, b-cell 42 46
lymphoma b-cell 44


Related Diseases for B-Cell Lymphomas

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the B-Cell Lymphomas family:

T-Cell Lymphoma 1a

Diseases related to B-Cell Lymphomas via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse large b-cell lymphoma32.4PASD1
2gastric lymphoma31.4BCL10, BCL6, MALT1
3leukemia31.4BCL10, BCL3, BCL11B, BCL6, PAX5, CD5
4central nervous system lymphoma31.3BCL6
5hodgkin's lymphoma31.2PAX5, IRF4, BCL3, BCL6
6mantle cell lymphoma31.1CCND1, BCL6
7non-hodgkin lymphoma31.0IRF4, CCND1, MALT1, MYC, CD5, BCL6
8chronic lymphocytic leukemia31.0BCL3, BCL10, CCND1, CD5, PAX5, BCL6
9burkitt's lymphoma30.9BCL6, BCL3, PAX5, CCND1
10anaplastic large cell lymphoma30.9BCL3, PAX5, BCL6
11macroglobulinemia30.9CD5, PAX5
12hairy cell leukemia30.7CCND1, CD5, BCL6
13myeloma30.6IRF4, MYC, CCND1, BCL6, PAX5
14plasmacytoma30.6MYC, PAX5, BCL6, IRF4
15myeloid leukemia30.5MYC, PIM1
16multiple myeloma30.5CCND1, IRF4, TP53
17prolymphocytic leukemia30.4MYC, CD5, CCND1
18retinoblastoma30.4MYC, CCND1, BCL3, TP53
19malt lymphoma30.3CCND1, CD5, BCL10, MALT1, BCL6, IRF4
20b-cell chronic lymphocytic leukemia30.0PAX5, CD5, CCND1, BCL10
21lymphoma, diffuse large cell30.0MYC, PAX5, BCL6
22reticulosarcoma30.0BCL6, PAX5, BCL3
23gallbladder lymphoma30.0MALT1, BCL10
24marginal zone b-cell lymphoma11.3
25mediastinitis11.1
26bone lymphoma10.9
27splenic marginal zone lymphoma10.8
28hepatitis b10.8
29hepatitis10.8
30lung lymphoma10.7
31breast lymphoma10.7
32composite lymphoma10.7
33adult lymphoma10.7
34gastrointestinal lymphoma10.7
35gray zone lymphoma10.6
36thyroid lymphoma10.6
37pediatric lymphoma10.6
38cutaneous t cell lymphoma10.6
39testicular lymphoma10.6
40thyroiditis10.6
41hepatitis c10.6
42colon lymphoma10.6
43hepatitis a10.6
44liver lymphoma10.5
45arthritis10.5
46rheumatoid arthritis10.5
47cerebritis10.5
48mediastinal gray zone lymphoma10.5
49orbit lymphoma10.5
50prostate lymphoma10.5

Graphical network of the top 20 diseases related to B-Cell Lymphomas:



Diseases related to b-cell lymphomas

Clinical Features for B-Cell Lymphomas

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Drugs & Therapeutics for B-Cell Lymphomas

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for B-Cell Lymphomas

Drug clinical trials:

Search ClinicalTrials for B-Cell Lymphomas

Search NIH Clinical Center for B-Cell Lymphomas

Search CenterWatch for B-Cell Lymphomas

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about B-Cell Lymphomas cell therapies at LifeMap Discovery.

Genetic Tests for B-Cell Lymphomas

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Anatomical Context for B-Cell Lymphomas

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Sources:
32MalaCards
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MalaCards organs/tissues related to B-Cell Lymphomas:

32
B cells, Bone

Animal Models for B-Cell Lymphomas or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to B-Cell Lymphomas:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4CCND1, BCL11A, TP53, BCL3, BCL11B, BCL6
2MP:000538712.3IRF4, MALT1, MYC, CD5, PAX5, BCL11B
3MP:000538412.1BCL6, TP53, BCL11A, BCL10, BCL3, BCL11B
4MP:000301211.5MYC, CD5, BCL6, BCL11B, BCL11A, TP53

Publications for B-Cell Lymphomas

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Genetic Variations for B-Cell Lymphomas

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Expression for genes affiliated with B-Cell Lymphomas

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with B-Cell Lymphomas

Search GEO for disease gene expression data for B-Cell Lymphomas.

Pathways for genes affiliated with B-Cell Lymphomas

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Sources:
4Cell Signaling Technology, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 49PharmGKB
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Pathways related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4BCL10, BCL11B, BCL6, PAX5, MALT1, PIM1
2
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11.2TP53, BCL9L, BCL9, MYC, CCND1
311.2PIR, PIM1, MALT1, MYC, BCL10
4
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11.1CCND1, MYC, BCL6, TP53
511.1TP53, BCL9, MYC, CCND1
611.1MYC, PAX5, BCL6, TP53
7
Hide members
11.1CCND1, MALT1, MYC, BCL10
811.1IRF4, PIR, MALT1, BCL10
911.1CCND1, PIM1, MYC, PAX5
10
Hide members
11.1CCND1, PIM1, MYC, TP53
1111.1CCND1, PIM1, MYC, TP53
1210.9BCL6, MYC, CCND1
1310.9CCND1, MYC, BCL9
14
Hide members
10.9CCND1, MYC, TP53
1510.9CCND1, MYC, TP53
1610.9TP53, MYC, CCND1
17
Hide members
10.9TP53, MYC, CCND1
1810.9TP53, MYC, CCND1
19
Hide members
10.9CCND1, MYC, TP53
2010.9CCND1, MYC, TP53
2110.9TP53, MYC, CCND1
22
Hide members
10.9CCND1, MYC, TP53
2310.9TP53, MYC, CCND1
2410.9TP53, MYC, CCND1
2510.9MYC, PIM1, CCND1
2610.9TP53, MYC, PIM1

Compounds for genes affiliated with B-Cell Lymphomas

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1paraffin4411.9TP53, BCL6, PAX5, CD5, MYC, MALT1
2vincristine44 49 1113.4TP53, BCL6, MYC, CCND1
3[alcl]4411.3MYC, PAX5, BCL3
4sodium arsenite4411.3TP53, MYC, CCND1
5depsipeptide4411.3CCND1, MYC, TP53
6suberoylanilide hydroxamic acid4411.2TP53, MYC, CCND1
72-methoxyestradiol44 59 2413.2CCND1, PAX5, TP53
8serine4411.2CCND1, PIM1, MYC, PAX5, BCL6, BCL10
9n-(4-hydroxyphenyl)retinamide4411.2CCND1, MYC, TP53
10cytidine44 11 2413.2MYC, PAX5, BCL6
11roscovitine4411.2CCND1, MYC, TP53
12melphalan44 1112.2CCND1, MYC, TP53
13bortezomib44 1112.1TP53, MYC, CCND1
14tanshinone iia4411.1TP53, MYC
15doxorubicin44 49 1113.1TP53, BCL6, MYC, CCND1
16geldanamycin44 49 59 1114.1TP53, PIM1, CCND1
17gemcitabine44 49 1113.0TP53, MYC, CCND1
18pga24411.0MYC, CCND1
19lactacystin4411.0CCND1, MYC, TP53
20cyclopamine44 5912.0CCND1, MYC
21rapamycin4411.0CCND1, PIM1, MYC, BCL3
2210-hydroxycamptothecin4411.0MYC, TP53
23everolimus49 44 1112.8MYC, CCND1

GO Terms for genes affiliated with B-Cell Lymphomas

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Sources:
16Gene Ontology
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Cellular components related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.0TP53, CCND1, IRF4, PIR, PIM1, MALT1
2protein complexGO:04323411.1MALT1, MYC, BCL3, BCL10, TP53
3replication forkGO:00565710.8TP53, BCL6
4CBM complexGO:03244910.5BCL10, MALT1

Biological processes related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594412.1TP53, IRF4, MYC, PAX5, BCL11B, BCL9
2negative regulation of apoptotic processGO:04306611.6PIM1, MALT1, MYC, BCL11B, BCL3, TP53
3response to DNA damage stimulusGO:00697411.5CCND1, MYC, BCL6, BCL3, TP53
4positive regulation of transcription, DNA-dependentGO:04589311.4IRF4, MYC, BCL3, BCL10, TP53
5canonical Wnt receptor signaling pathwayGO:06007011.4BCL9L, BCL9, MYC, CCND1
6protein import into nucleus, translocationGO:00006011.2BCL6, BCL3, TP53
7positive regulation of interleukin-10 biosynthetic processGO:04508211.0BCL3, IRF4
8regulation of T cell receptor signaling pathwayGO:05085611.0BCL10, MALT1
9response to fungusGO:00962011.0MALT1, BCL10
10germinal center formationGO:00246710.9BCL6, BCL3
11response to molecule of bacterial originGO:00223710.9BCL10, MALT1
12mitotic G1 DNA damage checkpointGO:03157110.8TP53, CCND1
13DNA damage response, signal transduction by p53 class mediatorGO:03033010.8BCL3, TP53
14response to X-rayGO:01016510.8TP53, CCND1
15positive regulation of T cell activationGO:05087010.7BCL10, MALT1
16defense response to protozoanGO:04283210.5BCL3, IRF4

Molecular functions related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.6MYC, MALT1, PIM1, PIR, IRF4, CCND1
2transcription factor bindingGO:00813411.4TP53, BCL10, BCL3, MYC, PIM1, IRF4
3sequence-specific DNA binding transcription factor activityGO:00370011.4TP53, BCL3, BCL6, PAX5, MYC, IRF4
4protease bindingGO:00202010.8MALT1, BCL10, TP53
5kinase activator activityGO:01920910.5BCL10, MALT1

Products for genes affiliated with B-Cell Lymphomas

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for B-Cell Lymphomas

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet