MCID: BCL006
MIFTS: 57

B-Cell Lymphomas malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for B-Cell Lymphomas

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Disease Ontology:8 A non-hodgkin lymphoma that has material basis in b cells.

MalaCards based summary: B-Cell Lymphomas, also known as lymphoma, b-cell, is related to malt lymphoma and follicular lymphoma. An important gene associated with B-Cell Lymphomas is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are TFs Regulate miRNAs related to cardiac hypertrophy and Immune response NFAT in immune response. The drugs rituximab and ibritumomab tiuxetan have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone.

Aliases & Classifications for B-Cell Lymphomas

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B-Cell Lymphomas, Aliases & Descriptions:

Name: B-Cell Lymphomas 30 42 62
Lymphoma, B-Cell 9 42 46 62
B-Cell Lymphocytic Neoplasm 8 62
 
B-Cell Lymphoma 8
Lymphoma B-Cell 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:707
SNOMED-CT57 413616009
NCIt39 C27907

Related Diseases for B-Cell Lymphomas

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Diseases in the B-Cell Lymphomas family:

T-Cell Lymphoma 1a

Diseases related to B-Cell Lymphomas via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 379)
idRelated DiseaseScoreTop Affiliating Genes
1malt lymphoma31.7IGH, BCL6
2follicular lymphoma31.6BCL6, TCL1A, TNFRSF13C, IGH
3peripheral t-cell lymphoma31.5BCL6, TCL1A
4chronic lymphocytic leukemia31.4TCL1A, BCL6, IGH
5hodgkin's lymphoma31.4IGH, BCL6, TCL1A
6burkitt's lymphoma31.4IGH, TCL1A, BCL6
7plasmacytoma31.2IGH, BCL6
8myeloma31.1IGH, TCL1A, BCL6, NFKB2
9central nervous system lymphoma31.0BCL6
10common variable immunodeficiency31.0TNFRSF13C
11gastric lymphoma30.9IGH, BCL6
12non-hodgkin lymphoma30.4HOXC5, IGH, TNFRSF13C, TCL1A, BCL6
13reticulosarcoma30.4IGH, BCL6
14diffuse large b-cell lymphoma11.7
15marginal zone b-cell lymphoma11.4
16intravascular large b-cell lymphoma11.2
17mediastinitis11.1
18primary mediastinal large b-cell lymphoma11.1
19leukemia11.0
20indolent b cell lymphoma10.9
21primary cutaneous marginal zone b-cell lymphoma10.9
22t-cell/histiocyte rich large b cell lymphoma10.9
23nodal marginal zone b-cell lymphoma10.8
24hepatitis10.8
25primary cutaneous diffuse large b-cell lymphoma, leg type10.8
26mantle cell lymphoma10.7
27epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.7
28thyroiditis10.7
29hepatitis c10.7
30nodular lymphocyte predominant hodgkin lymphoma10.7
31arthritis10.6
32hepatitis c virus10.6
33endotheliitis10.6
34rheumatoid arthritis10.6
35macroglobulinemia10.6
36gray zone lymphoma10.6
37histiocytosis10.6
38angioimmunoblastic t-cell lymphoma10.6
39alk-positive large b-cell lymphoma10.6
40composite lymphoma10.6
41cerebritis10.6
42prostatitis10.6
43anaplastic large cell lymphoma10.5
44splenic marginal zone lymphoma10.5
45adenocarcinoma10.5
46amyloidosis10.5
47diffuse large b-cell lymphoma of the central nervous system10.5
48cryoglobulinemia10.5
49mediastinal gray zone lymphoma10.5
50pemphigus10.5

Graphical network of the top 20 diseases related to B-Cell Lymphomas:



Diseases related to b-cell lymphomas

Symptoms for B-Cell Lymphomas

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Drugs & Therapeutics for B-Cell Lymphomas

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Drug clinical trials:

Search ClinicalTrials for B-Cell Lymphomas

Search NIH Clinical Center for B-Cell Lymphomas

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about B-Cell Lymphomas cell therapies at LifeMap Discovery.

Genetic Tests for B-Cell Lymphomas

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Anatomical Context for B-Cell Lymphomas

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MalaCards organs/tissues related to B-Cell Lymphomas:

32
B cells, T cells, Bone, Bone marrow, Lung, Skin, Breast, Thyroid, Colon, Endothelial, Spleen, Liver, Prostate, Lymph node, Small intestine, Salivary gland, Uterus, Monocytes, Testis, Thymus, Brain, Myeloid, Kidney, Tonsil, Pituitary, Spinal cord, B lymphoblasts, Neutrophil, Heart, Smooth muscle, Ovary, Testes, Nk cells, Retina, Pancreas, Cervix, Appendix

Animal Models for B-Cell Lymphomas or affiliated genes

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Publications for B-Cell Lymphomas

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Articles related to B-Cell Lymphomas:

(show top 50)    (show all 3055)
idTitleAuthorsYear
1
Novel Immunotherapies for B-Cell Lymphomas and Leukemias. (25237982)
2014
2
Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus. (25197401)
2014
3
Influence of polymorphisms in ERCC5, XPA and MTR DNA repair and synthesis genes in B-cell lymphoma risk. A case-control study in Spanish population. (23818366)
2013
4
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene. (23457195)
2013
5
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome. (23859481)
2013
6
Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP. (24220563)
2013
7
Infusion Rate Escalation Study of Rituximab in Patients with CD20+ B-Cell Lymphomas: A Single Institution Analysis in Japan. (23691364)
2013
8
Paradoxical Regulation of Hypoxia Inducible Factor-1I+ (HIF-1I+) by Histone Deacetylase Inhibitor in Diffuse Large B-Cell Lymphoma. (24312289)
2013
9
MicroRNAs as prognostic markers in indolent primary cutaneous B-cell lymphoma. (22936066)
2013
10
An international confirmatory study of the prognostic value of early PET/CT in diffuse large B-cell lymphoma: comparison between Deauville criteria and I9SUVmax. (23649463)
2013
11
Pediatric Burkitt's Lymphoma and Diffuse B-Cell Lymphoma: Are Surveillance Scans Required? (24087880)
2013
12
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
13
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas. (24223701)
2013
14
Lenalidomide in diffuse large B-cell lymphomas. (22792112)
2012
15
A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine. (21239866)
2011
16
Treatment of patients with refractory diffuse large B-cell lymphoma or mantle cell lymphoma with alemtuzumab, alone or in combination with cytotoxic chemotherapy. (21067447)
2011
17
A fatal case of hemoperitoneum after ultrasound-guided liver biopsy in a patient with intravascular large B-cell lymphoma. (21377915)
2011
18
FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type. (21154235)
2011
19
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. (21173233)
2011
20
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas. (21638516)
2011
21
Pulmonary marginal zone B-cell lymphoma of MALT type--what is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) study. (20024551)
2010
22
18F-FDG PET/CT in a case of intravascular large B-cell lymphoma. (20607536)
2010
23
Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. (20651244)
2010
24
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
25
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
26
Retreatment with rituximab in 178 patients with relapsed and refractory B-cell lymphomas: a single institution case control study. (20038227)
2010
27
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
28
Caspase 3a: new prognostic marker for diffuse large B-cell lymphoma in the rituximab era. (20919853)
2010
29
Nuclear expression of YB-1 in diffuse large B-cell lymphoma: correlation with disease activity and patient outcome. (19500133)
2009
30
BCL2 expression in de novo diffuse large B-cell lymphoma partly reflects normal differences in age distribution. (19508293)
2009
31
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)
2008
32
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (18539616)
2008
33
Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas. (18312353)
2008
34
Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma. (17567982)
2007
35
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin. (17516749)
2007
36
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. (16424392)
2006
37
Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. (16497967)
2006
38
CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-). (16923582)
2006
39
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the lateral ventricle. (16194887)
2005
40
Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma. (14979479)
2004
41
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
42
Mutations of the BIK gene in human peripheral B-cell lymphomas. (12874789)
2003
43
Alpha-2,6-sialylation of L-PHA reactive oligosaccharides and expression of N-acetylglucosaminyltransferase V in human diffuse large B cell lymphoma. (14534692)
2003
44
Pathobiology of primary mediastinal B-cell lymphoma. (15202521)
2003
45
Plasma exchange and continuous hemodiafiltration as an initial treatment for diffuse large B-cell lymphoma-associated hemophagocytic syndrome]. (11868363)
2002
46
Role of radiation therapy in the management of primary mediastinal large B-cell lymphoma (PMLBL). (12553345)
2002
47
Somatically mutated regions of immunoglobulin on human B-cell lymphomas code for peptides that bind to autologous major histocompatibility complex class I, providing a potential target for cytotoxic T cells. (11431353)
2001
48
A reassessment of primary thyroid lymphoma: high-grade MALT-type lymphoma as a distinct subtype of diffuse large B-cell lymphoma. (10931213)
2000
49
Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome. (10192704)
1999
50
Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases. (7573673)
1995

Variations for B-Cell Lymphomas

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Expression for genes affiliated with B-Cell Lymphomas

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Expression patterns in normal tissues for genes affiliated with B-Cell Lymphomas

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Pathways for genes affiliated with B-Cell Lymphomas

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Pathways related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MIR125B1, MIR29A
2
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.7IGH, IGK, NFKB2
3
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.7IGH, NFKB2, IGK
4
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.5IGH, IGK, BCL6, NFKB2
59.1MIR16-1, MIR15A, MIR24-1, MIR29A, MIR223
69.1MIR16-1, MIR15A, MIR223, MIR29A, MIR125B1

Compounds for genes affiliated with B-Cell Lymphomas

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GO Terms for genes affiliated with B-Cell Lymphomas

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Biological processes related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:03089010.1BCL6, TNFRSF13C
2germinal center formationGO:0024679.9NFKB2, BCL6

Products for genes affiliated with B-Cell Lymphomas

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Sources for B-Cell Lymphomas

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet