MCID: BCL006
MIFTS: 49

B-Cell Lymphomas malady

Rare diseases, Immune diseases categories

Summaries for B-Cell Lymphomas

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34MalaCards
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MalaCards: B-Cell Lymphomas, also known as lymphoma, b-cell, is related to follicular lymphoma and malt lymphoma. An important gene associated with B-Cell Lymphomas is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are TFs Regulate miRNAs related to cardiac hypertrophy and Immune response NFAT in immune response. The drugs ibritumomab tiuxetan and rituximab have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone.

Aliases & Classifications for B-Cell Lymphomas

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Sources:
44NIH Rare Diseases, 32LifeMap Discoveryā„¢, 63UMLS, 48OMIM, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

b-cell lymphomas 44 32 63
lymphoma, b-cell 44 48
lymphoma b-cell 46


Related Diseases for B-Cell Lymphomas

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the B-Cell Lymphomas family:

T-Cell Lymphoma 1a

Diseases related to B-Cell Lymphomas via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 362)
idRelated DiseaseScoreTop Affiliating Genes
1follicular lymphoma31.4BCL6, TCL1A, TNFRSF13C, IGH
2malt lymphoma31.4IGH, BCL6
3hodgkin's lymphoma31.1IGH, BCL6, TCL1A
4peripheral t-cell lymphoma31.1BCL6, TCL1A
5burkitt's lymphoma31.0IGH, TCL1A, BCL6
6chronic lymphocytic leukemia31.0IGK, TNFRSF13C, IGH, TCL1A, BCL6
7b-cell chronic lymphocytic leukemia30.8TCL1A, BCL6, IGH
8plasmacytoma30.8IGH, BCL6
9myeloma30.8IGH, TCL1A, BCL6, NFKB2
10central nervous system lymphoma30.5BCL6
11gastric lymphoma30.5IGH, BCL6
12reticulosarcoma30.1IGH, BCL6
13non-hodgkin lymphoma30.1HOXC5, IGH, TNFRSF13C, TCL1A, BCL6
14diffuse large b-cell lymphoma11.6
15marginal zone b-cell lymphoma11.3
16intravascular large b-cell lymphoma11.2
17mediastinitis11.1
18primary mediastinal large b-cell lymphoma11.0
19leukemia11.0
20indolent b cell lymphoma10.9
21primary cutaneous marginal zone b-cell lymphoma10.9
22nodal marginal zone b-cell lymphoma10.8
23t-cell/histiocyte rich large b cell lymphoma10.8
24hepatitis10.8
25primary cutaneous diffuse large b-cell lymphoma, leg type10.7
26mantle cell lymphoma10.7
27epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.7
28gray zone lymphoma10.6
29thyroiditis10.6
30macroglobulinemia10.6
31hepatitis c10.6
32nodular lymphocyte predominant hodgkin lymphoma10.6
33arthritis10.6
34rheumatoid arthritis10.6
35hepatitis c virus10.6
36endotheliitis10.6
37cerebritis10.6
38histiocytosis10.6
39prostatitis10.6
40angioimmunoblastic t-cell lymphoma10.6
41alk-positive large b-cell lymphoma10.6
42mediastinal gray zone lymphoma10.5
43splenic marginal zone lymphoma10.5
44anaplastic large cell lymphoma10.5
45amyloidosis10.5
46diffuse large b-cell lymphoma of the central nervous system10.5
47cryoglobulinemia10.5
48lymphoplasmacytic lymphoma10.5
49hairy cell leukemia10.5
50pemphigus10.5

Graphical network of the top 20 diseases related to B-Cell Lymphomas:



Diseases related to b-cell lymphomas

Symptoms for B-Cell Lymphomas

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Drugs & Therapeutics for B-Cell Lymphomas

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for B-Cell Lymphomas

Drug clinical trials:

Search ClinicalTrials for B-Cell Lymphomas

Search NIH Clinical Center for B-Cell Lymphomas

Search CenterWatch for B-Cell Lymphomas

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about B-Cell Lymphomas cell therapies at LifeMap Discovery.

Genetic Tests for B-Cell Lymphomas

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Anatomical Context for B-Cell Lymphomas

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34MalaCards
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MalaCards organs/tissues related to B-Cell Lymphomas:

34
B cells, T cells, Bone, Bone marrow, Lung, Skin, Breast, Thyroid, Colon, Spleen, Liver, Endothelial, Prostate, Lymph node, Monocytes, Salivary gland, Uterus, Small intestine, Testis, Brain, Myeloid, Thymus, Pituitary, Tonsil, Kidney, B lymphoblasts, Spinal cord, Nk cells, Testes, Smooth muscle, Heart, Appendix, Cervix, Ovary, Retina

Animal Models for B-Cell Lymphomas or affiliated genes

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Publications for B-Cell Lymphomas

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Sources:
53PubMed
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Articles related to B-Cell Lymphomas:

(show top 50)    (show all 2900)
idTitleAuthorsYear
1
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene. (23457195)
2013
2
Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome. (23859481)
2013
3
Activation of the STAT3 Signaling Pathway Is Associated With Poor Survival in Diffuse Large B-Cell Lymphoma Treated With R-CHOP. (24220563)
2013
4
Infusion Rate Escalation Study of Rituximab in Patients with CD20+ B-Cell Lymphomas: A Single Institution Analysis in Japan. (23691364)
2013
5
Paradoxical Regulation of Hypoxia Inducible Factor-1I+ (HIF-1I+) by Histone Deacetylase Inhibitor in Diffuse Large B-Cell Lymphoma. (24312289)
2013
6
An international confirmatory study of the prognostic value of early PET/CT in diffuse large B-cell lymphoma: comparison between Deauville criteria and I9SUVmax. (23649463)
2013
7
Pediatric Burkitt's Lymphoma and Diffuse B-Cell Lymphoma: Are Surveillance Scans Required? (24087880)
2013
8
Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-Cell Lymphoma (MALT Lymphoma). (23767042)
2013
9
Massive transcriptional perturbation in subgroups of diffuse large B-cell lymphomas. (24223701)
2013
10
Lenalidomide in diffuse large B-cell lymphomas. (22792112)
2012
11
A case of monoclonal gammopathy in extranodal marginal zone B-cell lymphoma of the small intestine. (21239866)
2011
12
Treatment of patients with refractory diffuse large B-cell lymphoma or mantle cell lymphoma with alemtuzumab, alone or in combination with cytotoxic chemotherapy. (21067447)
2011
13
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
14
A fatal case of hemoperitoneum after ultrasound-guided liver biopsy in a patient with intravascular large B-cell lymphoma. (21377915)
2011
15
FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type. (21154235)
2011
16
Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. (21173233)
2011
17
Molecular characterization of 9p21 deletions shows a minimal common deleted region removing CDKN2A exon 1 and CDKN2B exon 2 in diffuse large B-cell lymphomas. (21638516)
2011
18
Pulmonary marginal zone B-cell lymphoma of MALT type--what is a prognostic factor and which is the optimal treatment, operation, or chemotherapy?: Consortium for Improving Survival of Lymphoma (CISL) study. (20024551)
2010
19
18F-FDG PET/CT in a case of intravascular large B-cell lymphoma. (20607536)
2010
20
Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. (20651244)
2010
21
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
22
A novel flow cytometric antibody panel for distinguishing Burkitt lymphoma from CD10+ diffuse large B-cell lymphoma. (20395518)
2010
23
Retreatment with rituximab in 178 patients with relapsed and refractory B-cell lymphomas: a single institution case control study. (20038227)
2010
24
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
25
Caspase 3a: new prognostic marker for diffuse large B-cell lymphoma in the rituximab era. (20919853)
2010
26
Primary mediastinal large B-cell lymphoma in HIV: report of two cases. (19669223)
2009
27
Nuclear expression of YB-1 in diffuse large B-cell lymphoma: correlation with disease activity and patient outcome. (19500133)
2009
28
BCL2 expression in de novo diffuse large B-cell lymphoma partly reflects normal differences in age distribution. (19508293)
2009
29
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. (17916749)
2008
30
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas. (18539616)
2008
31
Expression of TNF-receptor associated factor 2 correlates with poor progression-free survival time in ABC-like primary nodal diffuse large B-cell lymphomas. (18312353)
2008
32
Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma. (17567982)
2007
33
Comparison of ataxia-telangiectasia mutated protein expression in diffuse large B-cell lymphomas of primary central nervous system and non-central nervous system origin. (17516749)
2007
34
CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model. (17513732)
2007
35
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. (16424392)
2006
36
Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. (16497967)
2006
37
CD5-positive diffuse large B-cell lymphoma with an unusual phenotype: Cytoplasmic CD20 (+), surface CD20 (-). (16923582)
2006
38
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the lateral ventricle. (16194887)
2005
39
Coexistent rearrangements of c-MYC, BCL2, and BCL6 genes in a diffuse large B-cell lymphoma. (14979479)
2004
40
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
41
Mutations of the BIK gene in human peripheral B-cell lymphomas. (12874789)
2003
42
Alpha-2,6-sialylation of L-PHA reactive oligosaccharides and expression of N-acetylglucosaminyltransferase V in human diffuse large B cell lymphoma. (14534692)
2003
43
Pathobiology of primary mediastinal B-cell lymphoma. (15202521)
2003
44
Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation. (14691303)
2003
45
Plasma exchange and continuous hemodiafiltration as an initial treatment for diffuse large B-cell lymphoma-associated hemophagocytic syndrome]. (11868363)
2002
46
Role of radiation therapy in the management of primary mediastinal large B-cell lymphoma (PMLBL). (12553345)
2002
47
Somatically mutated regions of immunoglobulin on human B-cell lymphomas code for peptides that bind to autologous major histocompatibility complex class I, providing a potential target for cytotoxic T cells. (11431353)
2001
48
A reassessment of primary thyroid lymphoma: high-grade MALT-type lymphoma as a distinct subtype of diffuse large B-cell lymphoma. (10931213)
2000
49
Cerebral B-cell lymphoma following treatment for Tolosa-Hunt syndrome. (10192704)
1999
50
Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases. (7573673)
1995

Variations for B-Cell Lymphomas

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Expression for genes affiliated with B-Cell Lymphomas

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with B-Cell Lymphomas

Search GEO for disease gene expression data for B-Cell Lymphomas.

Pathways for genes affiliated with B-Cell Lymphomas

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51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 13EMD Millipore, 55R&D Systems, 31KEGG
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Pathways related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MIR125B1, MIR29A
2
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.7IGH, IGK, NFKB2
3
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.7IGH, NFKB2, IGK
4
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.5IGH, IGK, BCL6, NFKB2
59.1MIR16-1, MIR15A, MIR24-1, MIR29A, MIR223
69.1MIR16-1, MIR15A, MIR223, MIR29A, MIR125B1

Compounds for genes affiliated with B-Cell Lymphomas

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GO Terms for genes affiliated with B-Cell Lymphomas

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17Gene Ontology
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Biological processes related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:03089010.1BCL6, TNFRSF13C
2germinal center formationGO:0024679.9NFKB2, BCL6

Products for genes affiliated with B-Cell Lymphomas

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Sources for B-Cell Lymphomas

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet