MCID: BCL006
MIFTS: 58

B-Cell Lymphomas malady

Immune category

Summaries for B-Cell Lymphomas

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: B-Cell Lymphomas, also known as lymphoma, b-cell, is related to lymphoma, diffuse large cell and diffuse large b-cell lymphoma. An important gene associated with B-Cell Lymphomas is BCL6 (B-cell CLL/lymphoma 6), and among its related pathways are Lymphocyte Signaling and Wnt signaling pathway. The drugs ibritumomab tiuxetan and rituximab and the compounds paraffin and vincristine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone marrow, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for B-Cell Lymphomas

Sources:
43NIH Rare Diseases, 31LifeMap Discovery™, 61UMLS, 47OMIM, 45Novoseek
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

b-cell lymphomas 43 31 61
lymphoma, b-cell 43 47
lymphoma b-cell 45


Related Diseases for B-Cell Lymphomas

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the B-Cell Lymphomas family:

t-cell lymphoma 1a

Diseases related to B-Cell Lymphomas via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 323)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell32.4MYC, PAX5, BCL6
2diffuse large b-cell lymphoma31.9PASD1
3gastric lymphoma31.5BCL10, BCL6, MALT1
4follicular lymphoma31.4CD5, PAX5, BCL3, BCL10, BCL6, MYC
5central nervous system lymphoma31.3BCL6
6central nervous system lymphoma, primary31.1BCL6, PIM1, PAX5
7mantle cell lymphoma31.1CCND1, BCL6
8burkitt's lymphoma31.0PAX5, TP53, CCND1, BCL10, BCL11B, BCL6
9peripheral t-cell lymphoma30.9CD5, BCL3, BCL6, PAX5
10anaplastic large cell lymphoma30.9BCL3, PAX5, BCL6
11macroglobulinemia30.9CD5, PAX5
12b-cell chronic lymphocytic leukemia30.6PAX5, CD5, CCND1, BCL10
13plasma cell leukemia30.5CCND1
14lymphoma, malt, somatic30.4CCND1, CD5, BCL10, MALT1, BCL6, IRF4
15reticulosarcoma30.0BCL6, PAX5, BCL3
16gallbladder lymphoma30.0MALT1, BCL10
17bone lymphoma10.9
18intravascular large b-cell lymphoma10.8
19splenic marginal zone lymphoma10.8
20t-cell leukemia10.8
21leukemia/lymphoma, t-cell10.8
22lung lymphoma10.7
23composite lymphoma10.7
24lymphoma, somatic10.7
25breast lymphoma10.7
26adult lymphoma10.7
27hepatitis c10.7
28primary bone lymphoma10.7
29gastrointestinal lymphoma10.7
30hepatitis c virus10.7
31colon lymphoma10.6
32thyroid lymphoma10.6
33pediatric lymphoma10.6
34primary mediastinal large b-cell lymphoma10.6
35testicular lymphoma10.6
36nodular lymphocyte predominant hodgkin lymphoma10.6
37n syndrome10.6
38indolent b cell lymphoma10.6
39liver lymphoma10.6
40arthritis10.6
41mediastinal gray zone lymphoma10.5
42orbit lymphoma10.5
43hepatitis d10.5
44cerebral lymphoma10.5
45richter's syndrome10.5
46lymphoplasmacytic lymphoma10.5
47amyloidosis10.5
48primary cutaneous marginal zone b-cell lymphoma10.5
49plasmablastic lymphoma10.5
50cryoglobulinemia10.5

Graphical network of the top 20 diseases related to B-Cell Lymphomas:



Diseases related to b-cell lymphomas

Clinical Features for B-Cell Lymphomas

Drugs & Therapeutics for B-Cell Lymphomas

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for B-Cell Lymphomas

Drug clinical trials:

Search ClinicalTrials for B-Cell Lymphomas

Search NIH Clinical Center for B-Cell Lymphomas

Search CenterWatch for B-Cell Lymphomas

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about B-Cell Lymphomas cell therapies at LifeMap Discovery.

Genetic Tests for B-Cell Lymphomas

Anatomical Context for B-Cell Lymphomas

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to B-Cell Lymphomas:

33
Skin, Lymph node, Bone marrow, Smooth muscle, Small intestine, Breast, Testis, Tonsil, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Testis germ

Animal Models for B-Cell Lymphomas or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to B-Cell Lymphomas:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.4CCND1, BCL11A, TP53, BCL3, BCL11B, BCL6
2MP:000538712.3IRF4, MALT1, MYC, CD5, PAX5, BCL11B
3MP:000538412.1BCL6, TP53, BCL11A, BCL10, BCL3, BCL11B
4MP:000301211.5MYC, CD5, BCL6, BCL11B, BCL11A, TP53

Publications for B-Cell Lymphomas

Sources:
51PubMed
See all sources

Articles related to B-Cell Lymphomas:

(show top 50)    (show all 251)
idTitleAuthorsYear
1
Survivin Messenger RNA Levels in Epstein-Barr Virus-Positive Patients With Leukemic Low-Grade B-Cell Lymphomas Expressing the Latent Membrane Protein 1: Evidence of Apoptotic Function? (24262330)
2013
2
Double-hit B-cell lymphomas with BCL6 and MYC translocations are aggressive, frequently extranodal lymphomas distinct from BCL2 double-hit B-cell lymphomas. (23348205)
2013
3
LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. (23795761)
2013
4
Very poor performance status elderly patients with aggressive B cell lymphomas can benefit from intensive chemotherapy. (22188201)
2012
5
Pityriasis lichenoides et varioliformis acuta with numerous CD30(+) cells: a variant mimicking lymphomatoid papulosis and other cutaneous lymphomas. A clinicopathologic, immunohistochemical, and molecular biological study of 13 cases. (22472952)
2012
6
Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissues. (21366462)
2011
7
Down-regulation of BLIMP1I+ by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas. (21411757)
2011
8
High expression of LMO2 in Hodgkin, Burkitt and germinal center diffuse large B cell lymphomas. (22776842)
2011
9
Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases. (19935644)
2010
10
Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells. (20220060)
2010
11
Epstein-Barr virus (EBV) genotypes among human immunodeficiency virus (HIV)-related B-cell lymphomas and B-cell post-transplant lymphoproliferative disorders (B-PTLD)--late-onset lymphomas, especially in the HIV setting, are associated with type-B-EBV. (20408873)
2010
12
Nodular pattern of bone marrow infiltration: frequent finding in immunosuppression-related EBV-associated large B-cell lymphomas. (19806362)
2009
13
Bone marrow histology in marginal zone B-cell lymphomas: correlation with clinical parameters and flow cytometry in 120 patients. (18718888)
2009
14
The frequency of immunoglobulin heavy chain gene and T-cell receptor gamma-chain gene rearrangements and Epstein-Barr virus in ALK+ and ALK- anaplastic large cell lymphoma and other peripheral T-cell lymphomas. (18832464)
2008
15
A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas. (18277385)
2008
16
Comparative biodistributions of pretargeted radioimmunoconjugates targeting CD20, CD22, and DR molecules on human B-cell lymphomas. (17303693)
2007
17
New treatment concepts in diffuse large B-cell lymphomas (DLBL): chemothe-rapy and biological therapy. (18474000)
2007
18
Transcriptional profiling suggests that secondary and primary large B-cell lymphomas of the gastrointestinal (GI) tract are blastic variants of GI marginal zone lymphoma. (17152084)
2007
19
A tree-based decision rule for identifying profile groups of cases without predefined classes: application in diffuse large B-cell lymphomas. (16895724)
2007
20
Clinicopathological features of primary cutaneous B-cell lymphomas from an academic regional hospital in central Italy: no evidence of Borrelia burgdorferi association. (17926178)
2007
21
Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. (16497967)
2006
22
Variable expression of Epstein-Barr virus-induced gene 3 during normal B-cell differentiation and among B-cell lymphomas. (16639698)
2006
23
PCR-based clonality analysis of B-cell lymphomas in paraffin-embedded tissues: diagnostic value of immunoglobulin kappa and lambda light chain gene rearrangement investigation. (16677778)
2006
24
Rapid detection of clonal T-cell receptor-beta gene rearrangements in T-Cell lymphomas using the LightCycler-polymerase chain reaction with DNA melting curve analysis. (15681478)
2005
25
Expression of the NF-kappaB targets BCL2 and BIRC5/Survivin characterizes small B-cell and aggressive B-cell lymphomas, respectively. (15880597)
2005
26
Circulating endothelial cells, endothelial precursors, VEGF and bFGF concentrations in patients with acute leukemias, lymphomas and myelomas]. (16130598)
2005
27
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
28
Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. (15041742)
2004
29
Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component. (15277222)
2004
30
Increased expression of the bcl6 and CD10 proteins is associated with increased apoptosis and proliferation in diffuse large B-cell lymphomas. (12748254)
2003
31
Telomerase activity in B-cell non-Hodgkin lymphomas is regulated by hTERT transcription and correlated with telomere-binding protein expression but uncoupled from proliferation. (12915884)
2003
32
Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. (12780797)
2003
33
The latency pattern of Epstein-Barr virus infection and viral IL-10 expression in cutaneous natural killer/T-cell lymphomas. (11286472)
2001
34
Decreased expression of Fas (APO-1/CD95) on peripheral blood CD4+ T lymphocytes in cutaneous T-cell lymphomas. (11122022)
2000
35
Structure of the MLT gene and molecular characterization of the genomic breakpoint junctions in the t(11;18)(q21;q21) of marginal zone B-cell lymphomas of MALT type. (11066071)
2000
36
Anaplastic large cell lymphomas presented as bone lesions: a clinicopathologic study of six cases and review of the literature. (11048810)
2000
37
Mobilisation of peripheral blood stem cells with IVE and G-CSF improves CD34+ cell yields and engraftment in patients with non-Hodgkin's lymphomas and Hodgkin's disease. (10516673)
1999
38
A biological role for deletions in chromosomal band 13q14 in mantle cell and peripheral t-cell lymphomas? (10502318)
1999
39
Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior. (10433941)
1999
40
Bone marrow versus peripheral blood progenitor cells CD34 selection in patients with non-Hodgkin's lymphomas: different levels of tumor cell reduction. Implications for autografting. (9326252)
1997
41
Peripheral blood progenitor cell mobilization with Dexa-Beam/G-CSF, ether lipid purging, and autologous transplantation after high-dose CBV treatment: a safe and effective regimen in patients with poor risk malignant lymphomas. (9031111)
1996
42
"Small" B-cell non-Hodgkin's lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma. A study based on histology, cytology, immunohistochemistry, and cytogenetic analysis. (8554111)
1996
43
Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin D1 gene. (7545645)
1995
44
High frequency of Epstein-Barr virus latent membrane protein-1 expression in acquired immunodeficiency syndrome-related Ki-1 (CD30)-positive anaplastic large-cell lymphomas. Italian Cooperative Group on AIDS and Tumors. (8209867)
1994
45
In vivo phenotypic characteristics of AKR T-cell lymphomas with different leukemic potential: possible role of alpha 4 beta 7 integrin in the progression towards the leukemic phenotype. (8112892)
1994
46
Expression of leukocyte adhesion molecules (ICAM-1/LFA-1) related to clinical behaviour in B cell lymphomas. (1356904)
1992
47
Cytokine expression in T-cell lymphomas and Hodgkin's disease. Its possible implication in autocrine or paracrine production as a potential basis for neoplastic growth. (1951632)
1991
48
Differentiation of human B-cell malignant lymphomas is independent of the octamer lymphoid specific binding factor (Oct-2). (1937571)
1991
49
MYC rearrangement and translocations involving band 8q24 in diffuse large cell lymphomas. (1671647)
1991
50
Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. (1967431)
1990

Genetic Variations for B-Cell Lymphomas

Expression for genes affiliated with B-Cell Lymphomas

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with B-Cell Lymphomas

Search GEO for disease gene expression data for B-Cell Lymphomas.

Pathways for genes affiliated with B-Cell Lymphomas

Sources:
4Cell Signaling Technology, 30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4BCL6, MALT1, PAX5, PIM1, BCL11B, BCL10
2
Hide members
11.2CCND1, MYC, BCL9, TP53, BCL9L
311.2BCL10, MYC, PIR, PIM1, MALT1
4
Hide members
11.1BCL6, CCND1, TP53, MYC
511.1CCND1, MYC, BCL9, TP53
611.1PAX5, MYC, BCL6, TP53
7
Hide members
11.1MYC, MALT1, BCL10, CCND1
811.1PIR, MALT1, BCL10, IRF4
911.1CCND1, PIM1, MYC, PAX5
10
Hide members
11.1TP53, MYC, PIM1, CCND1
1111.1MYC, TP53, CCND1, PIM1
1210.9BCL6, CCND1, MYC
1310.9MYC, CCND1, BCL9
14
Hide members
10.9CCND1, MYC, TP53
1510.9CCND1, MYC, TP53
1610.9TP53, MYC, CCND1
17
Hide members
10.9TP53, MYC, CCND1
1810.9CCND1, TP53, MYC
19
Hide members
10.9CCND1, TP53, MYC
2010.9CCND1, TP53, MYC
2110.9CCND1, MYC, TP53
22
Hide members
10.9CCND1, TP53, MYC
2310.9TP53, MYC, CCND1
2410.9MYC, TP53, CCND1
2510.9CCND1, MYC, PIM1
2610.9PIM1, MYC, TP53

Compounds for genes affiliated with B-Cell Lymphomas

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1paraffin4511.9PAX5, CCND1, MALT1, MYC, BCL6, TP53
2vincristine45 50 1113.4CCND1, TP53, BCL6, MYC
3[alcl]4511.3BCL3, MYC, PAX5
4sodium arsenite4511.3MYC, TP53, CCND1
5depsipeptide4511.3CCND1, MYC, TP53
6suberoylanilide hydroxamic acid4511.2MYC, TP53, CCND1
72-methoxyestradiol45 60 2413.2CCND1, TP53, PAX5
8serine4511.2BCL10, BCL6, PAX5, MYC, PIM1, CCND1
9n-(4-hydroxyphenyl)retinamide4511.2MYC, TP53, CCND1
10roscovitine4511.2TP53, MYC, CCND1
11cytidine45 11 2413.2BCL6, PAX5, MYC
12melphalan45 1112.2TP53, MYC, CCND1
13bortezomib45 1112.1CCND1, TP53, MYC
14tanshinone iia4511.1TP53, MYC
15doxorubicin45 50 1113.1TP53, BCL6, MYC, CCND1
16gemcitabine45 50 1113.1CCND1, MYC, TP53
17geldanamycin45 50 60 1114.0TP53, PIM1, CCND1
18pga24511.0MYC, CCND1
19lactacystin4511.0CCND1, TP53, MYC
20cyclopamine45 6012.0CCND1, MYC
21rapamycin4511.0MYC, CCND1, PIM1, BCL3
2210-hydroxycamptothecin4511.0MYC, TP53
23everolimus50 45 1112.8MYC, CCND1

GO Terms for genes affiliated with B-Cell Lymphomas

Sources:
16Gene Ontology
See all sources

Cellular components related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563413.0TP53, CCND1, IRF4, PIR, PIM1, MALT1
2protein complexGO:04323411.1MYC, BCL3, BCL10, TP53, MALT1
3replication forkGO:00565710.8BCL6, TP53
4CBM complexGO:03244910.5MALT1, BCL10

Biological processes related to B-Cell Lymphomas according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594412.1PAX5, BCL9, MYC, IRF4, BCL3, BCL11B
2negative regulation of apoptotic processGO:04306611.6PIM1, MYC, BCL11B, BCL3, TP53, MALT1
3response to DNA damage stimulusGO:00697411.5BCL6, TP53, BCL3, MYC, CCND1
4positive regulation of transcription, DNA-dependentGO:04589311.4IRF4, MYC, BCL10, TP53, BCL3
5canonical Wnt receptor signaling pathwayGO:06007011.4MYC, BCL9L, BCL9, CCND1
6protein import into nucleus, translocationGO:00006011.2TP53, BCL3, BCL6
7positive regulation of interleukin-10 biosynthetic processGO:04508211.0BCL3, IRF4
8regulation of T cell receptor signaling pathwayGO:05085611.0MALT1, BCL10
9response to fungusGO:00962011.0BCL10, MALT1
10germinal center formationGO:00246710.9BCL3, BCL6
11response to molecule of bacterial originGO:00223710.9BCL10, MALT1
12mitotic G1 DNA damage checkpointGO:03157110.8TP53, CCND1
13DNA damage response, signal transduction by p53 class mediatorGO:03033010.8TP53, BCL3
14response to X-rayGO:01016510.8TP53, CCND1
15positive regulation of T cell activationGO:05087010.7BCL10, MALT1
16defense response to protozoanGO:04283210.5BCL3, IRF4

Molecular functions related to B-Cell Lymphomas according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.6BCL6, PIR, CD5, MYC, MALT1, LASP1
2transcription factor bindingGO:00813411.4TP53, IRF4, PIM1, MYC, BCL3, BCL10
3sequence-specific DNA binding transcription factor activityGO:00370011.4BCL6, TP53, PAX5, MYC, IRF4, BCL3
4protease bindingGO:00202010.8TP53, BCL10, MALT1
5kinase activator activityGO:01920910.5BCL10, MALT1

Products for genes affiliated with B-Cell Lymphomas

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for B-Cell Lymphomas

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet