MCID: BBS001
MIFTS: 46

Babesiosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 10 45 12 51 36 2 65
Human Babesiosis 45 65
Babesia Parasite Infection 45
 
Infection by Babesia 10
Piroplasmosis 10
Babesiasis 10

Characteristics:

Orphanet epidemiological data:

51
babesiosis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult

Classifications:



External Ids:

Disease Ontology10 DOID:9643
ICD1027 B60.0
ICD9CM29 088.82
MeSH36 D001404
NCIt42 C84581
Orphanet51 108
ICD10 via Orphanet28 B60.0
MESH via Orphanet37 D001404
UMLS via Orphanet66 C0004576
UMLS65 C0004576, C2930674

Summaries for Babesiosis

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Disease Ontology:10 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

MalaCards based summary: Babesiosis, also known as human babesiosis, is related to tick infestation and neuronitis, and has symptoms including hemolytic anemia, migraine and abnormality of temperature regulation. An important gene associated with Babesiosis is CCT7 (Chaperonin Containing TCP1 Subunit 7), and among its related pathways are Reelin signaling pathway and Post-translational modification- synthesis of GPI-anchored proteins. The drugs quinine and quinine sulfate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and liver.

CDC:2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:68 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms for Babesiosis

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Symptoms:

 51 10 (show all 32)
  • facial pain/cephalalgia/migraine
  • hemolytic anemia
  • fever/chilling
  • hyperhidrosis/increased sweating
  • hepatitis/icterus/cholestasis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cough
  • anorexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • asthenia/fatigue/weakness
  • photophobia
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatocellular liver disease/hepatic failure
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • renal failure
  • obnubilation/coma/lethargia/desorientation
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • restricted joint mobility/joint stiffness/ankylosis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • blood hyperviscosity/hypercoagulability
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anemia described as malaria-like symptoms

HPO human phenotypes related to Babesiosis:

(show all 24)
id Description Frequency HPO Source Accession
1 hemolytic anemia hallmark (90%) HP:0001878
2 migraine hallmark (90%) HP:0002076
3 abnormality of temperature regulation hallmark (90%) HP:0004370
4 hyperhidrosis typical (50%) HP:0000975
5 splenomegaly typical (50%) HP:0001744
6 thrombocytopenia typical (50%) HP:0001873
7 leukopenia typical (50%) HP:0001882
8 anorexia typical (50%) HP:0002039
9 hepatomegaly typical (50%) HP:0002240
10 arthralgia typical (50%) HP:0002829
11 myalgia typical (50%) HP:0003326
12 renal insufficiency occasional (7.5%) HP:0000083
13 photophobia occasional (7.5%) HP:0000613
14 limitation of joint mobility occasional (7.5%) HP:0001376
15 hepatic failure occasional (7.5%) HP:0001399
16 congestive heart failure occasional (7.5%) HP:0001635
17 coronary artery disease occasional (7.5%) HP:0001677
18 weight loss occasional (7.5%) HP:0001824
19 nausea and vomiting occasional (7.5%) HP:0002017
20 respiratory insufficiency occasional (7.5%) HP:0002093
21 reduced consciousness/confusion occasional (7.5%) HP:0004372
22 thrombophlebitis occasional (7.5%) HP:0004418
23 hypercoagulability occasional (7.5%) HP:0100724
24 recurrent pharyngitis occasional (7.5%) HP:0100776

Drugs & Therapeutics for Babesiosis

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Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 34477
2AntibodiesPhase 34477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Babesia Testing in Blood DonorsCompletedNCT01528449Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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MalaCards organs/tissues related to Babesiosis:

33
Heart, Lung, Liver, Breast, Endothelial, Testes, Bone

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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Articles related to Babesiosis:

(show top 50)    (show all 543)
idTitleAuthorsYear
1
BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-I^ Responses. (26121674)
2015
2
Bone morphogenetic protein 4 and bone morphogenetic protein receptor expression in the pituitary gland of adult dogs in healthy condition and with ACTH-secreting pituitary adenoma. (26542941)
2015
3
Association of MnSOD AA Genotype with the Progression of Prostate Cancer. (26147925)
2015
4
Coil Migration to the Pulmonary Artery during Endovascular Embolization Treatment in a Patient with Arteriovenous Malformation in the Right Ear. (26568001)
2015
5
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. (26052095)
2015
6
A novel c.776_777insA mutation in CLN1 leads to infantile neuronal ceroid lipofuscinosis. (23857568)
2013
7
Cognitive development in patients with Mucopolysaccharidosis type III (Sanfilippo syndrome). (21689409)
2011
8
Voluminous intussusception involving the whole midgut in a teenager: a unique differentiation from abdominal cocoon. (21512845)
2011
9
Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells. (21220185)
2011
10
Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (20162745)
2010
11
Painful medial branch neuroma treated with minimally invasive medial branch neurectomy. (20456081)
2010
12
Relationship of nonsyndromic cleft lip and/or palate and poliovirus receptor-related 1 exon 3 polymorphisms in Han people of Jiangzhe area]. (19408722)
2009
13
Prevalence of auditory neuropathy (AN) among infants and young children with severe to profound hearing loss. (19409623)
2009
14
Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. (17593366)
2008
15
Aldosterone synthase gene polymorphism as a determinant of atrial fibrillation in patients with heart failure. (18638595)
2008
16
Thoracic chordoma: review and role of FDG-PET. (18946438)
2008
17
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West. (18795209)
2008
18
Influence of the APOE genotypes in some atherosclerotic risk factors]. (19187685)
2008
19
Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial. (17653121)
2007
20
Chronic viral diseases of the liver and oncoproteins externalization in hepatocytes]. (16729487)
2006
21
Gender differences in the expression of erythrocyte aggregation in relation to B beta-fibrinogen gene polymorphisms in apparently healthy individuals. (16525569)
2006
22
A case of breast cancer metastatic to the tail of the pancreas. (16755123)
2006
23
Cyclophilin a protects Peg3 from hypermethylation and inactive histone modification. (17071620)
2006
24
Management of chemotherapy-induced nausea, vomiting, oral mucositis, and diarrhoea. (15683818)
2005
25
Molecular targets of diabetic vascular complications and potential new drugs. (16026269)
2005
26
BNP as a biomarker in heart disease. (16355919)
2005
27
Gene expression of Toll-like receptor-2, Toll-like receptor-4, and MD2 is differentially regulated in rabbits with Escherichia coli pneumonia. (15656985)
2005
28
Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma. (15297175)
2004
29
Lack of association between ICAM-1 gene polymorphisms and biopsy-proven erythema nodosum. (14760823)
2004
30
Quantitation of SU1 1248, an oral multi-target tyrosine kinase inhibitor, and its metabolite in monkey tissues by liquid chromatograph with tandem mass spectrometry following semi-automated liquid-liquid extraction. (14753710)
2004
31
An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220. (12556447)
2003
32
Elevated levels of adhesion molecules derived from leukocytes and endothelial cells in patients with pregnancy-induced hypertension. (12648441)
2003
33
Localization of proteins bound to a replication origin of human DNA along the cell cycle. (12912926)
2003
34
Eleven novel JAK3 mutations in patients with severe combined immunodeficiency-including the first patients with mutations in the kinase domain. (11668621)
2001
35
Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter. (11740346)
2001
36
Effect of cocaine on chemokine and CCR-5 gene expression by mononuclear cells from normal donors and HIV-1 infected patients. (11727771)
2001
37
Quantifying the 5-HT1A agonist action of buspirone in man. (11713611)
2001
38
Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells. (10700460)
2000
39
The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene. (11122115)
2000
40
Clinicopathological characteristics of interstitial foam cells in membranous nephropathy. (10412760)
1999
41
A case of microphthalmos with cyst and partial trisomy 22. (9695091)
1998
42
Prenatal sonographic appearance of congenital fibrosarcoma. (9608374)
1998
43
Surface properties after a simulated PLA2 hydrolysis of pulmonary surfactant's main component, DPPC. (9084505)
1997
44
A temperature-sensitive mutant of human p53. (8013454)
1994
45
Contribution of serotonin neurotoxins to understanding psychiatric disorders: the role of 5-HT2 receptors in schizophrenia and antipsychotic activity. (7911139)
1993
46
Chondroma of the cervical spinal canal. Case report. (1306207)
1992
47
Fatal virus-associated hemophagocytic syndrome in a young adult producing nontraumatic splenic rupture. (1402765)
1992
48
Homologous and heterologous regulation of 1,25-dihydroxyvitamin D-3 receptor mRNA levels in human osteosarcoma cells. (1846564)
1991
49
Congenital myopathy with oculo-facial abnormalities (Marden-Walker syndrome). (1877612)
1991
50
Urinary steroidal pattern of infants with congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency. (6968003)
1980

Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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GO Terms for genes affiliated with Babesiosis

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Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1preassembly of GPI anchor in ER membraneGO:00162549.5PIGV, PIGW

Sources for Babesiosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet