MCID: BBS001
MIFTS: 58

Babesiosis malady

Infectious diseases category

Summaries for Babesiosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus babesia, which reproduce in red blood cells and cause hemolytic anemia. they are transmitted by ixodid ticks or by blood transfusion. babesiosis is a zoonotic disease.

MalaCards: Babesiosis, also known as human babesiosis, is related to systemic lupus erythematosus and ehrlichiosis, and has symptoms including thrombocytopenia/thrombopenia, hemolytic anemia and facial pain/cephalalgia/migraine. An important gene associated with Babesiosis is RPA4 (replication protein A4, 30kDa), and among its related pathways are Post-translational modification: synthesis of GPI-anchored proteins and Metabolism. The drugs quinine and quinine sulfate and the compounds phytosphingosine and sphinganine 1-phosphate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

CDC:3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:63 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal... more...

Aliases & Classifications for Babesiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
babesiosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

babesiosis 8 42 10 48 60
human babesiosis 42 60
babesia parasite infection 42
infection by babesia 8
piroplasmosis 8
babesiasis 8


External Ids:

Disease Ontology8 DOID:9643
MeSH34 D001404
NCIt39 C84581
ICD9CM27 088.82
MESH via Orphanet35 D001404
ICD10 via Orphanet26 B60.0
SNOMED-CT via Orphanet57 21061004
UMLS via Orphanet61 C0004576
ICD1025 B60.0

Related Diseases for Babesiosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Clinical Features for Babesiosis

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48Orphanet
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Symptoms:

48 (show all 32)
  • thrombocytopenia/thrombopenia
  • hemolytic anemia
  • facial pain/cephalalgia/migraine
  • anorexia
  • pharyngitis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • leukopenia/hypoleukocytosis
  • blood hyperviscosity/hypercoagulability
  • anemia described as malaria-like symptoms
  • hepatomegaly/liver enlargement (excluding storage disease)
  • venous thrombosis/phlebitis/thrombophlebitis
  • angor pectoris/myocardial infarction
  • myalgia/muscular pain
  • photophobia
  • obnubilation/coma/lethargia/desorientation
  • restricted joint mobility/joint stiffness/ankylosis
  • splenomegaly
  • early death/lethality
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • hyperhidrosis/increased sweating
  • asthenia/fatigue/weakness
  • renal failure
  • cough
  • heart/cardiac failure
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • hepatocellular liver disease/hepatic failure
  • hepatitis/icterus/cholestasis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • articular/joint pain/arthralgia
  • fever/chilling
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Babesiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Babesiosis

Drug clinical trials:

Search ClinicalTrials for Babesiosis

Search NIH Clinical Center for Babesiosis

Search CenterWatch for Babesiosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Babesiosis:

32
Liver, Testes, Heart, Lung, Pituitary, Thyroid, Endothelial, Kidney, T cells, Whole blood

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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Sources:
50PubMed
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Articles related to Babesiosis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France. (23448544)
2013
2
In this issue - June 2013: MRSA at a veterinary hospital A^ Complications after cranial cruciate ligament repair in dogs A^ Tidal breathing flow volume loop reference values A^ Mechanical ventilation for tick paralysis A^ Internal parasite control at Pony Clubs A^ Racing after pelvic fractures A^ Acellular aortic matrix for hernia repair A^ Babesiosis in a naA^ve herd. (23718788)
2013
3
Babesiosis among elderly Medicare beneficiaries, United States, 2006-2008. (22257500)
2012
4
Symptomatic babesiosis in systemic lupus erythematosus: report of a case and review of the literature. (22892003)
2012
5
Human babesiosis. (22716978)
2012
6
Transfusion-transmitted babesiosis: achieving successful mitigation while balancing cost and donor loss. (22780893)
2012
7
First diagnostic cases of human babesiosis in Montenegro. (22975172)
2012
8
High risk of QT interval prolongation and torsades de pointes associated with intravenous quinidine used for treatment of resistant malaria or babesiosis. (22615288)
2012
9
The factors affecting the distribution of babesiosis in dogs in Poland. (21524856)
2011
10
Babesiosis in immunocompetent patients, Europe. (21192869)
2011
11
Clinical management of canine babesiosis. (20230437)
2010
12
Molecular and biomorphometrical identification of ovine babesiosis in iran. (22347262)
2010
13
Transfusion medicine illustrated. The expanding range and severity of babesiosis. (20233358)
2010
14
Preliminary evaluation of the BrEMA1 gene as a tool for associating babesia rossi genotypes and clinical manifestation of canine Babesiosis. (19741079)
2009
15
Transfusion-transmitted babesiosis in Rhode Island. (19761547)
2009
16
Babesiosis in equines in Pakistan: a clinical report. (20391402)
2009
17
Infection and seroconversion of susceptible animals introduced into a babesiosis endemic area. (19120191)
2008
18
Remission of cunical signs of adult-onset generalized demodicosis after treatment for concurrent babesiosis and/or granulocytic ehrlichiosis in dogs. (18225424)
2007
19
A novel 57-kDa merozoite protein of Babesia gibsoni is a prospective antigen for diagnosis and serosurvey of canine babesiosis by enzyme-linked immunosorbent assay. (17706873)
2007
20
Live vaccines against bovine babesiosis. (16504404)
2006
21
Babesiosis and blood transfusion: flying under the radar. (16507014)
2006
22
Endocrine dysfunction in chronic severe ehrlichiosis with or without babesiosis in dogs. (17139541)
2006
23
Cardiac involvement in canine babesiosis. (15900893)
2005
24
Are urea and creatinine values reliable indicators of azotaemia in canine babesiosis? (15628803)
2004
25
Human babesiosis--an unrecorded reality. Absence of formal registry undermines its detection, diagnosis and treatment, suggesting need for immediate mandatory reporting. (15325004)
2004
26
Serological diagnosis of human babesiosis by IgG enzyme-linked immunosorbent assay. (15696612)
2004
27
Lyme disease and babesiosis: preliminary findings on the transmission risk in highly frequented areas of the Monti Sibillini National Park (Central Italy). (15631066)
2004
28
Electrocardiographic changes and cardiac pathology in canine babesiosis. (19083300)
2004
29
Naturally acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain. (12541061)
2003
30
Serological and parasitological study and report of the first case of human babesiosis in Colombia. (12937727)
2003
31
Acid-base balance in field cases of bovine babesiosis. (12803396)
2003
32
Babesiosis diagnosis and treatment. (12804380)
2003
33
Development of an immunohistochemical assay for the detection of babesiosis in formalin-fixed, paraffin-embedded tissue samples. (14671971)
2003
34
Canine babesiosis. (12910748)
2003
35
Acute babesiosis caused by Babesia divergens in a resident of Kentucky. (12200568)
2002
36
An epidemiological study on ovine babesiosis in the Mashhad suburb area, province of Khorasan, Iran. (12208039)
2002
37
Diagnosis of babesiosis using an immunoblot serologic test. (11687460)
2001
38
Risk of babesiosis and anaplasmosis in different ecological zones of Santa Cruz Department, Bolivia. (11027858)
2000
39
Human babesiosis: an emerging tick-borne disease. (11113258)
2000
40
A focus of feline babesiosis at Kaapschehoop on the Mpumalanga escarpment. (10855823)
1999
41
Babesiosis. (9779356)
1998
42
Isolation and characterization of a Babesia species from Rhipicephalus evertsi evertsi ticks picked off a sable antelope (Hippotragus niger) which died of acute babesiosis. (9741050)
1998
43
Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. (8637139)
1996
44
Current state and future trends in the diagnosis of babesiosis. (7597794)
1995
45
Development of conventional subunit vaccines for anaplasmosis and babesiosis. (7597788)
1995
46
Immunization of cattle with an inactivated polyvalent vaccine against anaplasmosis and babesiosis. (1626861)
1992
47
Preliminary observations on ticks and tick-borne diseases in the north west province of Cameroon. I. Babesiosis and anaplasmosis. (1824132)
1991
48
Heat shock response of Babesia divergens and identification of the hsp70 as an immunodominant early antigen during ox, gerbil and human babesiosis. (1756315)
1991
49
Estimation of the potential demand for a bovine babesiosis and anaplasmosis vaccine in Argentina. (2382381)
1990
50
Babesiosis--Connecticut. (2506413)
1989

Genetic Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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53Reactome, 29KEGG
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Compounds for genes affiliated with Babesiosis

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank
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Compounds related to Babesiosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1phytosphingosine44 2410.7PIGW, PIGM, PIGL, PIGV
2sphinganine 1-phosphate44 2410.7PIGV, PIGL, PIGM, PIGW
3sphinganine44 2410.7PIGV, PIGL, PIGM, PIGW
4sphingosine 1-phosphate28 2410.6PIGW, PIGM, PIGL, PIGV
5dihydroceramide44 2410.6PIGV, PIGL, PIGM, PIGW
6glucosylceramide44 2410.6PIGV, PIGL, PIGM, PIGW
7phosphatidylinositol-3,4,5-trisphosphate44 2410.6PIGW, PIGM, PIGL, PIGV
8sphingosine44 11 2411.5PIGV, PIGL, PIGM, PIGW
9ascorbic acid44 2410.1HSPA4, CRP, MT-CYB, TPO
10iron44 2410.1TPO, MT-CYB, CRP, HSPA4
11asparagine449.0MT-CYB, RAP1A, TPO
12fibrinogen449.0TPO, MASP1, CRP, HSPA4

GO Terms for genes affiliated with Babesiosis

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16Gene Ontology
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Cellular components related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.2DPM1, PIGW, PIGM, PIGL, PIGV

Biological processes related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1GPI anchor biosynthetic processGO:0065069.8DPM1, PIGL, PIGV
2preassembly of GPI anchor in ER membraneGO:0162549.4PIGV, PIGL, PIGM, PIGW
3C-terminal protein lipidationGO:0065019.3DPM1, PIGW, PIGM, PIGL, PIGV
4post-translational protein modificationGO:0436878.9PIGV, PIGL, PIGM, PIGW, DPM1
5cellular protein metabolic processGO:0442677.6RPLP2, CCT7, EXOC8, PIGV, PIGL, PIGM

Molecular functions related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannosyltransferase activityGO:00003010.0PIGM, PIGV

Products for genes affiliated with Babesiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Babesiosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet