MCID: BBS001
MIFTS: 46

Babesiosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 11 48 54 2 39 13 68
Human Babesiosis 48 68
Babesia Parasite Infection 48
 
Infection by Babesia 11
Piroplasmosis 11
Babesiasis 11

Characteristics:

Orphanet epidemiological data:

54
babesiosis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult

Classifications:



External Ids:

Disease Ontology11 DOID:9643
ICD1030 B60.0
ICD9CM32 088.82
MeSH39 D001404
NCIt45 C84581
Orphanet54 ORPHA108
UMLS via Orphanet69 C0004576
MESH via Orphanet40 D001404
ICD10 via Orphanet31 B60.0

Summaries for Babesiosis

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Disease Ontology:11 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

MalaCards based summary: Babesiosis, also known as human babesiosis, is related to tick infestation and lyme disease, and has symptoms including Array, Array and Array. An important gene associated with Babesiosis is CD36 (CD36 Molecule), and among its related pathways are Malaria and Reelin signaling pathway. The drugs quinine and quinine sulfate have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and endothelial.

CDC:2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:71 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms & Phenotypes for Babesiosis

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Symptoms:

 11
  • anemia described as malaria-like symptoms

Human phenotypes related to Babesiosis:

 54 64 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency64 54 Occasional (29-5%) HP:0000083
2 photophobia64 54 Occasional (29-5%) HP:0000613
3 depression64 54 Occasional (29-5%) HP:0000716
4 jaundice64 54 Frequent (79-30%) HP:0000952
5 hyperhidrosis64 54 Frequent (79-30%) HP:0000975
6 coma64 54 Occasional (29-5%) HP:0001259
7 confusion64 54 Occasional (29-5%) HP:0001289
8 limitation of joint mobility64 54 Occasional (29-5%) HP:0001376
9 hepatic failure64 54 Occasional (29-5%) HP:0001399
10 congestive heart failure64 54 Occasional (29-5%) HP:0001635
11 myocardial infarction64 54 Occasional (29-5%) HP:0001658
12 splenomegaly64 54 Frequent (79-30%) HP:0001744
13 clinodactyly of the 5th toe64 54 Occasional (29-5%) HP:0001864
14 thrombocytopenia64 54 Frequent (79-30%) HP:0001873
15 hemolytic anemia64 54 Very frequent (99-80%) HP:0001878
16 leukopenia64 54 Frequent (79-30%) HP:0001882
17 fever64 54 Very frequent (99-80%) HP:0001945
18 nausea and vomiting64 54 Occasional (29-5%) HP:0002017
19 anorexia64 54 Occasional (29-5%) HP:0002039
20 respiratory insufficiency64 54 Occasional (29-5%) HP:0002093
21 hepatomegaly64 54 Frequent (79-30%) HP:0002240
22 headache64 54 Very frequent (99-80%) HP:0002315
23 recurrent infections54 Frequent (79-30%)
24 arthralgia64 54 Frequent (79-30%) HP:0002829
25 myalgia64 54 Frequent (79-30%) HP:0003326
26 venous thrombosis64 54 Occasional (29-5%) HP:0004936
27 disseminated intravascular coagulation64 54 Occasional (29-5%) HP:0005521
28 fatigue64 54 Frequent (79-30%) HP:0012378
29 cough64 54 Frequent (79-30%) HP:0012735
30 hypercoagulability64 54 Occasional (29-5%) HP:0100724
31 recurrent pharyngitis64 54 Occasional (29-5%) HP:0100776

Drugs & Therapeutics for Babesiosis

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Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 36394
2AntibodiesPhase 36394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Babesia Testing in Blood DonorsCompletedNCT01528449Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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MalaCards organs/tissues related to Babesiosis:

36
Testes, Heart, Endothelial, Pituitary, T cells, Thyroid, Kidney

Publications for Babesiosis

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Articles related to Babesiosis:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Black-backed jackals (Canis mesomelas) are natural hosts of Babesia rossi, the virulent causative agent of canine babesiosis in sub-Saharan Africa. (28285591)
2017
2
Comparison between conventional and molecular methods for diagnosis of bovine babesiosis (Babesia bovis infection) in tick infested cattle in upper Egypt. (28316419)
2017
3
Autoimmune hemolytic anemia associated with babesiosis. (28405337)
2017
4
Hematologic manifestations of babesiosis. (28202022)
2017
5
Incidence of human babesiosis in Spain obtained from the diagnoses at hospital discharge. (28396138)
2017
6
Splenic dysfunction from celiac disease resulting in severe babesiosis. (28286145)
2017
7
Acute Atraumatic Splenic Hemorrhage: Babesiosis or Acute Infectious Mononucleosis. (28347760)
2017
8
Babesiosis-associated immune thrombocytopenia. (28217703)
2017
9
Utility of urinary markers in the assessment of renal dysfunction in canine babesiosis. (28074976)
2017
10
Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. (28054180)
2017
11
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone. (28399851)
2017
12
Blood markers of fibrinolysis and endothelial activation in canine babesiosis. (28363279)
2017
13
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. (28273010)
2017
14
Babesiosis acquired from a pet dog: a second reported case in Hong Kong. (27511969)
2016
15
Human Babesiosis, Bolivia, 2013. (27434696)
2016
16
Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis. (26953797)
2016
17
Tracing disease emergence: canine babesiosis in the UK. (27758918)
2016
18
A promising new ELISA diagnostic test for cattle babesiosis based on Babesia bigemina Apical Membrane Antigena891. (27033532)
2016
19
A review of canine babesiosis: the European perspective. (27289223)
2016
20
Spurious reticulocyte profiles in dogs with large form babesiosis: a retrospective study. (27701759)
2016
21
Escalations in the incidence of canine babesiosis over a period of 8A years (2006-2013) in Chennai, Tamil Nadu, India. (27876923)
2016
22
Persistence of babesiosis for >2 years in a patient on rituximab for rheumatoid arthritis. (27036977)
2016
23
Red cell exchange for a case of babesiosis. (27531166)
2016
24
Identification and characterization of profilin antigen among Babesia species as a common vaccine candidate against babesiosis. (27003460)
2016
25
Babesiosis in dogs. (26868242)
2016
26
Unexpected babesiosis in a patient with worsening anemia after allogeneic hematopoietic stem cell transplantation. (28092881)
2016
27
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus. (26745503)
2016
28
Atypical challenging and first case report of babesiosis in Ecuador. (27051577)
2016
29
Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites. (27246780)
2016
30
The Brief Case: Probable Transfusion-Transmitted Babesiosis in a Transplant Recipient. (27935831)
2016
31
Autochthonous babesiosis in the United Kingdom. (27112907)
2016
32
Traditional versus molecular based detection of a rare occurrence of babesiosis in Gir calf and its therapeutic management. (27876992)
2016
33
Plasma biomarkers of SIRS and MODS associated with canine babesiosis. (27033937)
2016
34
Acute Babesiosis in Pregnancy: A Novel Imitator of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome. (27275801)
2016
35
Availability of treatments for babesiosis in dogs. (27235482)
2016
36
Spurious reticulocyte profiles in a dog with babesiosis. (27755775)
2016
37
Modeling of babesipain-1 and identification of natural and synthetic leads for bovine babesiosis drug development. (26969677)
2016
38
Comparison of Babesia microti Real-Time Polymerase Chain Reaction Assays for Confirmatory Diagnosis of Babesiosis. (27928088)
2016
39
Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. (27270894)
2016
40
Clinicopatho-Biochemical Alterations Associated with Subclinical Babesiosis in Dairy Animals. (27308284)
2016
41
Canine babesiosis and tick activity monitored using companion animal electronic health records in the UK. (27484328)
2016
42
The prevalence of Dirofilaria repens in cats, healthy dogs and dogs with concurrent babesiosis in an expansion zone in central Europe. (27595920)
2016
43
Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis. (27306898)
2016
44
First Report of Babesia microti-Caused Babesiosis in Spain. (27560451)
2016
45
Closing the Brief Case: Probable Transfusion-Transmitted Babesiosis in a Transplant Recipient. (27935832)
2016
46
Transfusion-transmitted babesiosis: is it time to screen the blood supply? (27537475)
2016
47
Insulator-based dielectrophoretic diagnostic tool for babesiosis. (27375817)
2016
48
Exchange transfusion for babesiosis when, how, and how long? (27994385)
2016
49
Canine babesiosis: autochthonous today, endemic tomorrow? (27103693)
2016
50
Diagnosis and management of bovine babesiosis outbreaks in cattle in Punjab state. (28096607)
2016

Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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Pathways related to Babesiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CD36, THBS1
29.7LRPAP1, RAP1A
3
Show member pathways
9.6EXOC8, RAP1A

GO Terms for genes affiliated with Babesiosis

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Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of mitochondrial inner membraneGO:003130510.0COQ2, MT-CYB
2phagocytic vesicleGO:00453359.8CD36, RAP1A

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:003019410.4CD36, THBS1
2positive regulation of reactive oxygen species metabolic processGO:200037910.4CD36, THBS1
3response to calcium ionGO:00515929.7MT-CYB, THBS1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1low-density lipoprotein particle bindingGO:003016910.2CD36, THBS1
2transforming growth factor beta bindingGO:00504319.9CD36, THBS1

Sources for Babesiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet