MCID: BBS001
MIFTS: 46

Babesiosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 12 50 56 3 42 14 69
Human Babesiosis 50 69
Babesia Parasite Infection 50
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

56
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9643
ICD10 33 B60.0
ICD9CM 35 088.82
MeSH 42 D001404
NCIt 47 C84581
Orphanet 56 ORPHA108
UMLS via Orphanet 70 C0004576
MESH via Orphanet 43 D001404
ICD10 via Orphanet 34 B60.0
UMLS 69 C0004576

Summaries for Babesiosis

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to tick infestation and lyme disease, and has symptoms including anemia described as malaria-like symptoms, arthralgia and fatigue. An important gene associated with Babesiosis is CD36 (CD36 Molecule), and among its related pathways/superpathways are Malaria and Bisphosphonate Pathway, Pharmacodynamics. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and endothelial.

CDC : 3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia : 71 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Related Disease Score Top Affiliating Genes
1 tick infestation 11.2
2 lyme disease 10.2
3 ehrlichiosis 10.2
4 subdural empyema 10.1 CD36 THBS1
5 malaria 10.1
6 cerebritis 9.9
7 glanders 9.8
8 hemolytic anemia 9.8
9 human granulocytic anaplasmosis 9.8
10 acute respiratory distress syndrome 9.8
11 bartonellosis 9.8
12 thrombocytopenia 9.7
13 trypanosomiasis 9.7
14 endotheliitis 9.7
15 autoimmune hemolytic anemia 9.7
16 vasculitis 9.5
17 neutropenia 9.5
18 splenic infarction 9.5
19 lupus erythematosus 9.5
20 acute pancreatitis 9.5
21 evans' syndrome 9.5
22 myelitis 9.5
23 leishmaniasis 9.5
24 rocky mountain spotted fever 9.5
25 purpura 9.5
26 hypoglycemia 9.5
27 rheumatoid arthritis 9.5
28 sickle cell disease 9.5
29 systemic lupus erythematosus 9.5
30 retinitis 9.5
31 filariasis 9.5
32 theileriasis 9.5
33 transverse myelitis 9.5
34 cerebellar ataxia 9.5
35 mouth disease 9.5
36 cardiomyopathy 9.5
37 celiac disease 9.5
38 spotted fever 9.5
39 ataxia 9.5
40 sickle cell anemia 9.5
41 respiratory failure 9.5
42 hyperaldosteronism 9.5
43 adult respiratory distress syndrome 9.5
44 tick paralysis 9.5
45 pancreatitis 9.5
46 alopecia 9.5
47 lymphopenia 9.5
48 arthritis 9.5
49 chagas disease 9.5
50 hepatoblastoma 9.5

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Symptoms:

12
  • anemia described as malaria-like symptoms

Human phenotypes related to Babesiosis:

56 32 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Frequent (79-30%) HP:0002829
2 fatigue 56 32 Frequent (79-30%) HP:0012378
3 myalgia 56 32 Frequent (79-30%) HP:0003326
4 fever 56 32 Very frequent (99-80%) HP:0001945
5 headache 56 32 Very frequent (99-80%) HP:0002315
6 photophobia 56 32 Occasional (29-5%) HP:0000613
7 nausea and vomiting 56 32 Occasional (29-5%) HP:0002017
8 recurrent pharyngitis 56 32 Occasional (29-5%) HP:0100776
9 depression 56 32 Occasional (29-5%) HP:0000716
10 hyperhidrosis 56 32 Frequent (79-30%) HP:0000975
11 respiratory insufficiency 56 32 Occasional (29-5%) HP:0002093
12 splenomegaly 56 32 Frequent (79-30%) HP:0001744
13 hepatomegaly 56 32 Frequent (79-30%) HP:0002240
14 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
15 hemolytic anemia 56 32 Very frequent (99-80%) HP:0001878
16 hypercoagulability 56 32 Occasional (29-5%) HP:0100724
17 myocardial infarction 56 32 Occasional (29-5%) HP:0001658
18 congestive heart failure 56 32 Occasional (29-5%) HP:0001635
19 limitation of joint mobility 56 32 Occasional (29-5%) HP:0001376
20 thrombocytopenia 56 32 Frequent (79-30%) HP:0001873
21 venous thrombosis 56 32 Occasional (29-5%) HP:0004936
22 jaundice 56 32 Frequent (79-30%) HP:0000952
23 anorexia 56 32 Occasional (29-5%) HP:0002039
24 coma 56 32 Occasional (29-5%) HP:0001259
25 cough 56 32 Frequent (79-30%) HP:0012735
26 hepatic failure 56 32 Occasional (29-5%) HP:0001399
27 leukopenia 56 32 Frequent (79-30%) HP:0001882
28 confusion 56 32 Occasional (29-5%) HP:0001289
29 clinodactyly of the 5th toe 56 32 Occasional (29-5%) HP:0001864
30 disseminated intravascular coagulation 56 32 Occasional (29-5%) HP:0005521
31 recurrent infections 56 Frequent (79-30%)

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Babesia Testing in Blood Donors Completed NCT01528449 Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

39
Testes, Heart, Endothelial, Pituitary, T Cells, Kidney, Thyroid

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 603)
id Title Authors Year
1
Black-backed jackals (Canis mesomelas) are natural hosts of Babesia rossi, the virulent causative agent of canine babesiosis in sub-Saharan Africa. ( 28285591 )
2017
2
Comparison between conventional and molecular methods for diagnosis of bovine babesiosis (Babesia bovis infection) in tick infested cattle in upper Egypt. ( 28316419 )
2017
3
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
4
Hematologic manifestations of babesiosis. ( 28202022 )
2017
5
Incidence of human babesiosis in Spain obtained from the diagnoses at hospital discharge. ( 28396138 )
2017
6
Splenic dysfunction from celiac disease resulting in severe babesiosis. ( 28286145 )
2017
7
Acute Atraumatic Splenic Hemorrhage: Babesiosis or Acute Infectious Mononucleosis. ( 28347760 )
2017
8
Babesiosis-associated immune thrombocytopenia. ( 28217703 )
2017
9
Utility of urinary markers in the assessment of renal dysfunction in canine babesiosis. ( 28074976 )
2017
10
Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. ( 28054180 )
2017
11
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone. ( 28399851 )
2017
12
Blood markers of fibrinolysis and endothelial activation in canine babesiosis. ( 28363279 )
2017
13
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
14
Babesiosis acquired from a pet dog: a second reported case in Hong Kong. ( 27511969 )
2016
15
Human Babesiosis, Bolivia, 2013. ( 27434696 )
2016
16
Excessive Pro-Inflammatory Serum Cytokine Concentrations in Virulent Canine Babesiosis. ( 26953797 )
2016
17
Tracing disease emergence: canine babesiosis in the UK. ( 27758918 )
2016
18
A promising new ELISA diagnostic test for cattle babesiosis based on Babesia bigemina Apical Membrane Antigena891. ( 27033532 )
2016
19
A review of canine babesiosis: the European perspective. ( 27289223 )
2016
20
Spurious reticulocyte profiles in dogs with large form babesiosis: a retrospective study. ( 27701759 )
2016
21
Escalations in the incidence of canine babesiosis over a period of 8A years (2006-2013) in Chennai, Tamil Nadu, India. ( 27876923 )
2016
22
Persistence of babesiosis for >2 years in a patient on rituximab for rheumatoid arthritis. ( 27036977 )
2016
23
Red cell exchange for a case of babesiosis. ( 27531166 )
2016
24
Identification and characterization of profilin antigen among Babesia species as a common vaccine candidate against babesiosis. ( 27003460 )
2016
25
Babesiosis in dogs. ( 26868242 )
2016
26
Unexpected babesiosis in a patient with worsening anemia after allogeneic hematopoietic stem cell transplantation. ( 28092881 )
2016
27
In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus. ( 26745503 )
2016
28
Atypical challenging and first case report of babesiosis in Ecuador. ( 27051577 )
2016
29
Extensive Shared Chemosensitivity between Malaria and Babesiosis Blood-Stage Parasites. ( 27246780 )
2016
30
The Brief Case: Probable Transfusion-Transmitted Babesiosis in a Transplant Recipient. ( 27935831 )
2016
31
Autochthonous babesiosis in the United Kingdom. ( 27112907 )
2016
32
Traditional versus molecular based detection of a rare occurrence of babesiosis in Gir calf and its therapeutic management. ( 27876992 )
2016
33
Plasma biomarkers of SIRS and MODS associated with canine babesiosis. ( 27033937 )
2016
34
Acute Babesiosis in Pregnancy: A Novel Imitator of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome. ( 27275801 )
2016
35
Availability of treatments for babesiosis in dogs. ( 27235482 )
2016
36
Spurious reticulocyte profiles in a dog with babesiosis. ( 27755775 )
2016
37
Modeling of babesipain-1 and identification of natural and synthetic leads for bovine babesiosis drug development. ( 26969677 )
2016
38
Comparison of Babesia microti Real-Time Polymerase Chain Reaction Assays for Confirmatory Diagnosis of Babesiosis. ( 27928088 )
2016
39
Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. ( 27270894 )
2016
40
Clinicopatho-Biochemical Alterations Associated with Subclinical Babesiosis in Dairy Animals. ( 27308284 )
2016
41
Canine babesiosis and tick activity monitored using companion animal electronic health records in the UK. ( 27484328 )
2016
42
The prevalence of Dirofilaria repens in cats, healthy dogs and dogs with concurrent babesiosis in an expansion zone in central Europe. ( 27595920 )
2016
43
Recombinant methionine aminopeptidase protein of Babesia microti: immunobiochemical characterization as a vaccine candidate against human babesiosis. ( 27306898 )
2016
44
First Report of Babesia microti-Caused Babesiosis in Spain. ( 27560451 )
2016
45
Closing the Brief Case: Probable Transfusion-Transmitted Babesiosis in a Transplant Recipient. ( 27935832 )
2016
46
Transfusion-transmitted babesiosis: is it time to screen the blood supply? ( 27537475 )
2016
47
Insulator-based dielectrophoretic diagnostic tool for babesiosis. ( 27375817 )
2016
48
Exchange transfusion for babesiosis when, how, and how long? ( 27994385 )
2016
49
Canine babesiosis: autochthonous today, endemic tomorrow? ( 27103693 )
2016
50
Diagnosis and management of bovine babesiosis outbreaks in cattle in Punjab state. ( 28096607 )
2016

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.85 CD36 THBS1
2
Show member pathways
10.42 EXOC8 RAP1A
3 10.09 LRPAP1 RAP1A

GO Terms for Babesiosis

Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle GO:0045335 8.96 CD36 RAP1A
2 integral component of mitochondrial inner membrane GO:0031305 8.62 COQ2 MT-CYB

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.16 MT-CYB THBS1
2 positive regulation of reactive oxygen species metabolic process GO:2000379 8.96 CD36 THBS1
3 positive regulation of blood coagulation GO:0030194 8.62 CD36 THBS1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 8.96 CD36 THBS1
2 low-density lipoprotein particle binding GO:0030169 8.62 CD36 THBS1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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