MCID: BBS001
MIFTS: 47

Babesiosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 36MeSH, 2CDC, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 10 45 12 51 36 2 65
Human Babesiosis 45 65
Babesia Parasite Infection 45
 
Infection by Babesia 10
Piroplasmosis 10
Babesiasis 10

Characteristics:

Orphanet epidemiological data:

51
babesiosis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult

Classifications:



External Ids:

Disease Ontology10 DOID:9643
ICD1027 B60.0
ICD9CM29 088.82
MeSH36 D001404
NCIt42 C84581
Orphanet51 108
ICD10 via Orphanet28 B60.0
MESH via Orphanet37 D001404
UMLS via Orphanet66 C0004576
UMLS65 C0004576, C2930674

Summaries for Babesiosis

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Disease Ontology:10 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

MalaCards based summary: Babesiosis, also known as human babesiosis, is related to tick infestation and ehrlichiosis, and has symptoms including hemolytic anemia, migraine and abnormality of temperature regulation. An important gene associated with Babesiosis is CCT7 (Chaperonin Containing TCP1 Subunit 7), and among its related pathways are Reelin signaling pathway and Post-translational modification- synthesis of GPI-anchored proteins. The drugs quinine and quinine sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and thyroid.

CDC:2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:68 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms for Babesiosis

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Symptoms:

 51 10 (show all 32)
  • facial pain/cephalalgia/migraine
  • hemolytic anemia
  • fever/chilling
  • hyperhidrosis/increased sweating
  • hepatitis/icterus/cholestasis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cough
  • anorexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • asthenia/fatigue/weakness
  • photophobia
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatocellular liver disease/hepatic failure
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • renal failure
  • obnubilation/coma/lethargia/desorientation
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • restricted joint mobility/joint stiffness/ankylosis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • blood hyperviscosity/hypercoagulability
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anemia described as malaria-like symptoms

HPO human phenotypes related to Babesiosis:

(show all 24)
id Description Frequency HPO Source Accession
1 hemolytic anemia hallmark (90%) HP:0001878
2 migraine hallmark (90%) HP:0002076
3 abnormality of temperature regulation hallmark (90%) HP:0004370
4 hyperhidrosis typical (50%) HP:0000975
5 splenomegaly typical (50%) HP:0001744
6 thrombocytopenia typical (50%) HP:0001873
7 leukopenia typical (50%) HP:0001882
8 anorexia typical (50%) HP:0002039
9 hepatomegaly typical (50%) HP:0002240
10 arthralgia typical (50%) HP:0002829
11 myalgia typical (50%) HP:0003326
12 renal insufficiency occasional (7.5%) HP:0000083
13 photophobia occasional (7.5%) HP:0000613
14 limitation of joint mobility occasional (7.5%) HP:0001376
15 hepatic failure occasional (7.5%) HP:0001399
16 congestive heart failure occasional (7.5%) HP:0001635
17 coronary artery disease occasional (7.5%) HP:0001677
18 weight loss occasional (7.5%) HP:0001824
19 nausea and vomiting occasional (7.5%) HP:0002017
20 respiratory insufficiency occasional (7.5%) HP:0002093
21 reduced consciousness/confusion occasional (7.5%) HP:0004372
22 thrombophlebitis occasional (7.5%) HP:0004418
23 hypercoagulability occasional (7.5%) HP:0100724
24 recurrent pharyngitis occasional (7.5%) HP:0100776

Drugs & Therapeutics for Babesiosis

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Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 34477
2AntibodiesPhase 34477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Babesia Testing in Blood DonorsCompletedNCT01528449Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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MalaCards organs/tissues related to Babesiosis:

33
Liver, Testes, Thyroid, Heart, Bone, Lung, Kidney

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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Articles related to Babesiosis:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Plasma biomarkers of SIRS and MODS associated with canine babesiosis. (27033937)
2016
2
Babesiosis and other protists causing systemic infection. (26629447)
2015
3
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? (26481763)
2015
4
A Study of Naturally Acquired Canine Babesiosis Caused by Single and Mixed Babesia Species in Zambia: Clinicopathological Findings and Case Management. (26682062)
2015
5
HUMAN BABESIOSIS: A GENERAL REVIEW WITH SPECIAL REFERENCE TO EGYPT. (26939227)
2015
6
Babesiosis and Lyme disease co-infection in a female patient returning from the United States. (26525187)
2015
7
Detection and molecular characterization of canine babesiosis causative agent Babesia canis in the naturally infected dog in Lithuania. (25257504)
2014
8
Diagnostic methods used to monitor an outbreak of babesiosis (Babesia bovis) in a herd of feral cattle in New Caledonia. (23718796)
2013
9
Generalized alopecia with vasculitis-like changes in a dog with babesiosis. (23676299)
2013
10
Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France. (23448544)
2013
11
Babesiosis in a recently imported cat. (23264391)
2012
12
Human babesiosis. (22970965)
2012
13
Babesiosis in an Egyptian boy aquired from pet dog, and a general review. (21634246)
2011
14
Transfusion-associated babesiosis in the United States: a description of cases. (21893613)
2011
15
Persistent babesiosis in a stem cell transplant recipient. (21185598)
2011
16
Why is Southern African canine babesiosis so virulent? An evolutionary perspective. (21489239)
2011
17
Clinical management of canine babesiosis. (20230437)
2010
18
Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections. (20377861)
2010
19
Babesiosis in the immediate postoperative period after splenectomy for trauma. (19622029)
2009
20
Fatality despite appropriate treatment for babesiosis. (19500034)
2009
21
Preliminary evaluation of the BrEMA1 gene as a tool for associating babesia rossi genotypes and clinical manifestation of canine Babesiosis. (19741079)
2009
22
Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus casei. (19120190)
2008
23
Causative agents of canine babesiosis in Brazil. (17980446)
2008
24
The case of babesiosis in farmed wolf (Canis lupus L). (19055068)
2008
25
Canine babesiosis: a Brazilian perspective. (16962707)
2006
26
Haematuria due to babesiosis. (15938562)
2005
27
The impact of 2 dipping systems on endemic stability to bovine babesiosis and anaplasmosis in cattle in 4 communally grazed areas in Limpopo Province, South Africa. (16642719)
2005
28
Cardiac involvement in canine babesiosis. (15900893)
2005
29
Babesiosis: An Update on Epidemiology and Treatment. (12525291)
2003
30
Life-threatening hypotension from babesiosis hemolysis. (12098187)
2002
31
Lipid abnormalities in babesiosis. (10946820)
2000
32
Cloned lines of Babesia bovis differ in their ability to induce cerebral babesiosis in cattle. (10894468)
2000
33
Blood pressure changes in dogs with babesiosis. (10949511)
2000
34
Detection of enzootic babesiosis in baboons (Papio cynocephalus) and phylogenetic evidence supporting synonymy of the genera Entopolypoides and Babesia. (10203519)
1999
35
Concurrent babesiosis and Lyme disease diagnosed in Ontario. (9659788)
1998
36
Do babesiosis and malaria share a common disease process? (9683899)
1998
37
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in Malawi. (9203307)
1997
38
Response of babesiosis to a combined regimen of quinine and azithromycin. (9196774)
1997
39
Babesiosis in a patient with sickle cell anemia. (9217625)
1997
40
Babesiosis. (8729197)
1996
41
Spread of lymphatic filariasis, re-emergence of leishmaniasis & threat of babesiosis in India. (8926027)
1996
42
Current state and future trends in the diagnosis of babesiosis. (7597794)
1995
43
The level of infestation with the vector of cattle babesiosis in Argentina. (1343682)
1992
44
Fatal acute babesiosis in a juvenile wild dog (Lycaon pictus). (1569540)
1992
45
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992
46
Estimation of the potential demand for a bovine babesiosis and anaplasmosis vaccine in Argentina. (2382381)
1990
47
Effect of dexamethosone on babesiosis in Tatera indica (Hardwicke). (16414662)
1990
48
Tick-borne diseases of cattle in Paraguay. I. Seroepidemiological studies on anaplasmosis and babesiosis. (2321261)
1990
49
Bovine babesiosis on Nevis--implications for tick control. (2368265)
1990
50
Concurrent babesiosis and ehrlichiosis in the dog: blood smear examination supplemented by the indirect fluorescent antibody test, using Cowdria ruminantium as antigen. (2234860)
1990

Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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GO Terms for genes affiliated with Babesiosis

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Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1preassembly of GPI anchor in ER membraneGO:00162549.5PIGV, PIGW

Sources for Babesiosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet