MCID: BBS001
MIFTS: 50

Babesiosis malady

Rare diseases, Infectious diseases categories

Aliases & Classifications for Babesiosis

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 12DISEASES, 51Orphanet, 2CDC, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt, 29ICD9CM, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 10 45 12 51 2 65 36
Human Babesiosis 45 65
Babesia Parasite Infection 45
 
Infection by Babesia 10
Piroplasmosis 10
Babesiasis 10


Classifications:



Characteristics (Orphanet epidemiological data):

51
babesiosis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult


External Ids:

Disease Ontology10 DOID:9643
NCIt42 C84581
ICD9CM29 088.82
MeSH36 D001404
Orphanet51 108
ICD10 via Orphanet28 B60.0
MESH via Orphanet37 D001404
UMLS via Orphanet66 C0004576
ICD1027 B60.0

Summaries for Babesiosis

About this section
Disease Ontology:10 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus babesia, which reproduce in red blood cells and cause hemolytic anemia. they are transmitted by ixodid ticks or by blood transfusion. babesiosis is a zoonotic disease.

MalaCards based summary: Babesiosis, also known as human babesiosis, is related to ehrlichiosis and lyme disease, and has symptoms including hemolytic anemia, migraine and abnormality of temperature regulation. An important gene associated with Babesiosis is CD36 (CD36 Molecule (Thrombospondin Receptor)), and among its related pathways are Malaria and Reelin signaling pathway. The drugs quinine and quinine sulfate have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and liver.

CDC:2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:68 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal... more...

Related Diseases for Babesiosis

About this section

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms for Babesiosis

About this section

Symptoms:

 51 10 (show all 32)
  • facial pain/cephalalgia/migraine
  • hemolytic anemia
  • fever/chilling
  • hyperhidrosis/increased sweating
  • hepatitis/icterus/cholestasis
  • hepatomegaly/liver enlargement (excluding storage disease)
  • splenomegaly
  • cough
  • anorexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • leukopenia/hypoleukocytosis
  • thrombocytopenia/thrombopenia
  • asthenia/fatigue/weakness
  • photophobia
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hepatocellular liver disease/hepatic failure
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • venous thrombosis/phlebitis/thrombophlebitis
  • renal failure
  • obnubilation/coma/lethargia/desorientation
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • restricted joint mobility/joint stiffness/ankylosis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • blood hyperviscosity/hypercoagulability
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anemia described as malaria-like symptoms

HPO human phenotypes related to Babesiosis:

(show all 24)
id Description Frequency HPO Source Accession
1 hemolytic anemia hallmark (90%) HP:0001878
2 migraine hallmark (90%) HP:0002076
3 abnormality of temperature regulation hallmark (90%) HP:0004370
4 hyperhidrosis typical (50%) HP:0000975
5 splenomegaly typical (50%) HP:0001744
6 thrombocytopenia typical (50%) HP:0001873
7 leukopenia typical (50%) HP:0001882
8 anorexia typical (50%) HP:0002039
9 hepatomegaly typical (50%) HP:0002240
10 arthralgia typical (50%) HP:0002829
11 myalgia typical (50%) HP:0003326
12 renal insufficiency occasional (7.5%) HP:0000083
13 photophobia occasional (7.5%) HP:0000613
14 limitation of joint mobility occasional (7.5%) HP:0001376
15 hepatic failure occasional (7.5%) HP:0001399
16 congestive heart failure occasional (7.5%) HP:0001635
17 coronary artery disease occasional (7.5%) HP:0001677
18 weight loss occasional (7.5%) HP:0001824
19 nausea and vomiting occasional (7.5%) HP:0002017
20 respiratory insufficiency occasional (7.5%) HP:0002093
21 reduced consciousness/confusion occasional (7.5%) HP:0004372
22 thrombophlebitis occasional (7.5%) HP:0004418
23 hypercoagulability occasional (7.5%) HP:0100724
24 recurrent pharyngitis occasional (7.5%) HP:0100776

Drugs & Therapeutics for Babesiosis

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Babesia Testing in Blood DonorsCompletedNCT01528449Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: Babesiosis

Genetic Tests for Babesiosis

About this section

Anatomical Context for Babesiosis

About this section

MalaCards organs/tissues related to Babesiosis:

33
Testes, Heart, Liver, Lung, Pituitary, Endothelial, T cells

Animal Models for Babesiosis or affiliated genes

About this section

Publications for Babesiosis

About this section

Articles related to Babesiosis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Apheresis for babesiosis: Therapeutic parasite reduction or removal of harmful toxins or both? (26481763)
2015
2
Babesiosis and Lyme disease co-infection in a female patient returning from the United States. (26525187)
2015
3
Detection and molecular characterization of canine babesiosis causative agent Babesia canis in the naturally infected dog in Lithuania. (25257504)
2014
4
Diagnostic methods used to monitor an outbreak of babesiosis (Babesia bovis) in a herd of feral cattle in New Caledonia. (23718796)
2013
5
Generalized alopecia with vasculitis-like changes in a dog with babesiosis. (23676299)
2013
6
Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France. (23448544)
2013
7
Babesiosis in a recently imported cat. (23264391)
2012
8
Human babesiosis. (22970965)
2012
9
Babesiosis in an Egyptian boy aquired from pet dog, and a general review. (21634246)
2011
10
Transfusion-associated babesiosis in the United States: a description of cases. (21893613)
2011
11
Persistent babesiosis in a stem cell transplant recipient. (21185598)
2011
12
Why is Southern African canine babesiosis so virulent? An evolutionary perspective. (21489239)
2011
13
Clinical management of canine babesiosis. (20230437)
2010
14
Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections. (20377861)
2010
15
Efficacy of Ixodes ricinus as a vector of zoonotic babesiosis in Sinai Peninsula, Egypt. (21246957)
2010
16
Babesiosis in the immediate postoperative period after splenectomy for trauma. (19622029)
2009
17
Fatality despite appropriate treatment for babesiosis. (19500034)
2009
18
Preliminary evaluation of the BrEMA1 gene as a tool for associating babesia rossi genotypes and clinical manifestation of canine Babesiosis. (19741079)
2009
19
Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus casei. (19120190)
2008
20
Causative agents of canine babesiosis in Brazil. (17980446)
2008
21
The case of babesiosis in farmed wolf (Canis lupus L). (19055068)
2008
22
Canine babesiosis: a Brazilian perspective. (16962707)
2006
23
Haematuria due to babesiosis. (15938562)
2005
24
The impact of 2 dipping systems on endemic stability to bovine babesiosis and anaplasmosis in cattle in 4 communally grazed areas in Limpopo Province, South Africa. (16642719)
2005
25
Cardiac involvement in canine babesiosis. (15900893)
2005
26
Babesiosis: An Update on Epidemiology and Treatment. (12525291)
2003
27
Life-threatening hypotension from babesiosis hemolysis. (12098187)
2002
28
Lipid abnormalities in babesiosis. (10946820)
2000
29
Cloned lines of Babesia bovis differ in their ability to induce cerebral babesiosis in cattle. (10894468)
2000
30
Blood pressure changes in dogs with babesiosis. (10949511)
2000
31
Atovaquone and azithromycin for the treatment of babesiosis. (11078770)
2000
32
Detection of enzootic babesiosis in baboons (Papio cynocephalus) and phylogenetic evidence supporting synonymy of the genera Entopolypoides and Babesia. (10203519)
1999
33
Concurrent babesiosis and Lyme disease diagnosed in Ontario. (9659788)
1998
34
Do babesiosis and malaria share a common disease process? (9683899)
1998
35
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in Malawi. (9203307)
1997
36
Response of babesiosis to a combined regimen of quinine and azithromycin. (9196774)
1997
37
Babesiosis in a patient with sickle cell anemia. (9217625)
1997
38
Cross-sectional estimation of Babesia bovis antibody prevalence in an area of Argentina used for extensive cattle breeding as an aid to control babesiosis. (9234418)
1997
39
Babesiosis. (8729197)
1996
40
Spread of lymphatic filariasis, re-emergence of leishmaniasis & threat of babesiosis in India. (8926027)
1996
41
Current state and future trends in the diagnosis of babesiosis. (7597794)
1995
42
The level of infestation with the vector of cattle babesiosis in Argentina. (1343682)
1992
43
Fatal acute babesiosis in a juvenile wild dog (Lycaon pictus). (1569540)
1992
44
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992
45
Estimation of the potential demand for a bovine babesiosis and anaplasmosis vaccine in Argentina. (2382381)
1990
46
Effect of dexamethosone on babesiosis in Tatera indica (Hardwicke). (16414662)
1990
47
Tick-borne diseases of cattle in Paraguay. I. Seroepidemiological studies on anaplasmosis and babesiosis. (2321261)
1990
48
Bovine babesiosis on Nevis--implications for tick control. (2368265)
1990
49
Concurrent babesiosis and ehrlichiosis in the dog: blood smear examination supplemented by the indirect fluorescent antibody test, using Cowdria ruminantium as antigen. (2234860)
1990
50
The impact of cultural and environmental changes on the epidemiology and control of human babesiosis. (2696158)
1989

Variations for Babesiosis

About this section

Expression for genes affiliated with Babesiosis

About this section
Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

About this section

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CD36, THBS1
29.7LRPAP1, RAP1A

GO Terms for genes affiliated with Babesiosis

About this section

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of blood coagulationGO:003019410.3CD36, THBS1
2positive regulation of reactive oxygen species metabolic processGO:200037910.1CD36, THBS1
3preassembly of GPI anchor in ER membraneGO:00162549.6PIGV, PIGW
4GPI anchor biosynthetic processGO:00065069.6PIGV, PIGW
5platelet activationGO:00301689.5CD36, RAP1A, THBS1
6C-terminal protein lipidationGO:00065019.5PIGV, PIGW
7receptor-mediated endocytosisGO:00068989.5CD36, LRPAP1, MASP1
8cellular protein metabolic processGO:00442678.1CCT7, EXOC8, PIGV, PIGW, THBS1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:00504319.9CD36, THBS1
2low-density lipoprotein particle bindingGO:00301699.6CD36, THBS1

Sources for Babesiosis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet