MCID: BBS001
MIFTS: 51

Babesiosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 72 49 55 3 41 14 69
Human Babesiosis 49 69
Babesia Parasite Infection 49
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

55
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Babesiosis

NIH Rare Diseases : 49 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms. Last updated: 7/23/2017

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to tick infestation and lyme disease, and has symptoms including anemia described as malaria-like symptoms, renal insufficiency and photophobia. An important gene associated with Babesiosis is THBS1 (Thrombospondin 1), and among its related pathways/superpathways are Malaria and Bisphosphonate Pathway, Pharmacodynamics. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and pituitary.

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

CDC : 3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia : 72 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 tick infestation 11.3
2 lyme disease 10.3
3 ehrlichiosis 10.3
4 malaria 10.2
5 human granulocytic anaplasmosis 10.0
6 cerebritis 10.0
7 corneal neovascularization 9.9 CD36 THBS1
8 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
9 glanders 9.9
10 hemolytic anemia 9.9
11 bartonellosis 9.9
12 acute respiratory distress syndrome 9.9
13 anemia, autoimmune hemolytic 9.8
14 sickle cell anemia 9.8
15 thrombocytopenia 9.8
16 trypanosomiasis 9.8
17 endotheliitis 9.8
18 blood group--diego system 9.6
19 blood group, i system 9.6
20 systemic lupus erythematosus 9.6
21 rheumatoid arthritis 9.6
22 celiac disease 1 9.6
23 ataxia and polyneuropathy, adult-onset 9.6
24 aging 9.6
25 aceruloplasminemia 9.6
26 kala-azar 1 9.6
27 ataxia-oculomotor apraxia 3 9.6
28 infantile liver failure syndrome 1 9.6
29 b-cell expansion with nfkb and t-cell anergy 9.6
30 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.6
31 acute liver failure 9.6
32 adult respiratory distress syndrome 9.6
33 alopecia 9.6
34 arthritis 9.6
35 crohn's disease 9.6
36 hematopoietic stem cell transplantation 9.6
37 neutropenia 9.6
38 rocky mountain spotted fever 9.6
39 filariasis 9.6
40 spotted fever 9.6
41 respiratory failure 9.6
42 tick paralysis 9.6
43 chagas disease 9.6
44 filarial elephantiasis 9.6
45 pancytopenia 9.6
46 relapsing fever 9.6
47 thrombocytopenia due to platelet alloimmunization 9.6
48 splenic infarction 9.6
49 acute pancreatitis 9.6
50 myelitis 9.6

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Symptoms:

12
  • anemia described as malaria-like symptoms

Human phenotypes related to Babesiosis:

55 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0000083
2 photophobia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000613
3 jaundice 55 31 frequent (33%) Frequent (79-30%) HP:0000952
4 hyperhidrosis 55 31 frequent (33%) Frequent (79-30%) HP:0000975
5 coma 55 31 occasional (7.5%) Occasional (29-5%) HP:0001259
6 confusion 55 31 occasional (7.5%) Occasional (29-5%) HP:0001289
7 limitation of joint mobility 55 31 occasional (7.5%) Occasional (29-5%) HP:0001376
8 hepatic failure 55 31 occasional (7.5%) Occasional (29-5%) HP:0001399
9 congestive heart failure 55 31 occasional (7.5%) Occasional (29-5%) HP:0001635
10 myocardial infarction 55 31 occasional (7.5%) Occasional (29-5%) HP:0001658
11 splenomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0001744
12 clinodactyly of the 5th toe 55 31 occasional (7.5%) Occasional (29-5%) HP:0001864
13 thrombocytopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001873
14 hemolytic anemia 55 31 hallmark (90%) Very frequent (99-80%) HP:0001878
15 leukopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001882
16 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
17 nausea and vomiting 55 31 occasional (7.5%) Occasional (29-5%) HP:0002017
18 anorexia 55 31 occasional (7.5%) Occasional (29-5%) HP:0002039
19 respiratory insufficiency 55 31 occasional (7.5%) Occasional (29-5%) HP:0002093
20 hepatomegaly 55 31 frequent (33%) Frequent (79-30%) HP:0002240
21 headache 55 31 hallmark (90%) Very frequent (99-80%) HP:0002315
22 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
23 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
24 venous thrombosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0004936
25 disseminated intravascular coagulation 55 31 occasional (7.5%) Occasional (29-5%) HP:0005521
26 fatigue 55 31 frequent (33%) Frequent (79-30%) HP:0012378
27 cough 55 31 frequent (33%) Frequent (79-30%) HP:0012735
28 hypercoagulability 55 31 occasional (7.5%) Occasional (29-5%) HP:0100724
29 recurrent pharyngitis 55 31 occasional (7.5%) Occasional (29-5%) HP:0100776
30 depression 55 Occasional (29-5%)
31 recurrent infections 55 Frequent (79-30%)
32 depressivity 31 occasional (7.5%) HP:0000716

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Babesia Testing in Blood Donors Completed NCT01528449 Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

38
Testes, Heart, Pituitary, Kidney, Endothelial, Liver, Thyroid

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 633)
# Title Authors Year
1
Bovine babesiosis: Cattle protected in the field with a frozen vaccine containing Babesia bovis and Babesia bigemina cultured in vitro with a serum-free medium. ( 29155165 )
2018
2
Screening of patient blood samples for babesiosis using enzymatic assays. ( 29150323 )
2018
3
Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015. ( 29383735 )
2018
4
Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis. ( 29360801 )
2018
5
Human babesiosis in Southeast China: A case report. ( 29355731 )
2018
6
Comparison between conventional and molecular methods for diagnosis of bovine babesiosis (Babesia bovis infection) in tick infested cattle in upper Egypt. ( 28316419 )
2017
7
Babesiosis - of joint Romanian and US ancestry. ( 29107633 )
2017
8
Babesiosis in Long Island: review of 62 cases focusing on treatment with azithromycin and atovaquone. ( 28399851 )
2017
9
Alteration of haemostatic parameters in uncomplicated canine babesiosis. ( 28750862 )
2017
10
Vector-borne parasitic infections in dogs in the Baltic and Nordic countries: A questionnaire study to veterinarians on canine babesiosis and infections with Dirofilaria immitis and Dirofilaria repens. ( 28917320 )
2017
11
First record of locally acquired human babesiosis in Canada caused by Babesia duncani: a case report. ( 28890784 )
2017
12
Evaluation of the efficacy of sarolaner (SimparicaAr) in the prevention of babesiosis in dogs. ( 28877743 )
2017
13
Incidence of human babesiosis in Spain obtained from the diagnoses at hospital discharge. ( 28396138 )
2017
14
Clinical outbreak of babesiosis caused by Babesia capreoli in captive reindeer (Rangifer tarandus tarandus) in the Netherlands. ( 28648772 )
2017
15
Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis. ( 28722598 )
2017
16
Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules. ( 29040286 )
2017
17
False Positive HIV Result and Low CD4 in Babesiosis. ( 28801382 )
2017
18
Variable clinical presentations of babesiosis: A case series. ( 29040182 )
2017
19
Congenital Babesiosis After Maternal Infection With Borrelia burgdorferi and Babesia microti. ( 28992325 )
2017
20
Splenic dysfunction from celiac disease resulting in severe babesiosis. ( 28286145 )
2017
21
Tick, Diseases, Babesiosis ( 28613466 )
2017
22
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
23
Babesiosis Presenting as Acute Liver Failure. ( 29430231 )
2017
24
Black-backed jackals (Canis mesomelas) are natural hosts of Babesia rossi, the virulent causative agent of canine babesiosis in sub-Saharan Africa. ( 28285591 )
2017
25
Concurrent babesiosis and serological evidence of Lyme disease in a young patient. ( 28634526 )
2017
26
Correction: Human babesiosis: Indication of a molecular mimicry between thrombospondin domains from a novel Babesia microti BmP53 protein and host platelets molecules. ( 29206874 )
2017
27
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
28
Prevalence of babesiosis (Babesia bovis and Babesia bigemina) in cattle and water buffalo in Nueva Ecija, Philippines using Nested Polymerase Chain Reaction ( 29419989 )
2017
29
Utility of urinary markers in the assessment of renal dysfunction in canine babesiosis. ( 28074976 )
2017
30
Blood markers of fibrinolysis and endothelial activation in canine babesiosis. ( 28363279 )
2017
31
Status of babesiosis among domestic herbivores in Iran: a systematic review and meta-analysis. ( 28054180 )
2017
32
Cases of transfusion-transmitted babesiosis occurring in nonendemic areas: a diagnostic dilemma. ( 28782120 )
2017
33
Babesiosis-associated immune thrombocytopenia. ( 28217703 )
2017
34
Molecular and serological detection of bovine babesiosis in Indonesia. ( 29110723 )
2017
35
Babesiosis Surveillance - Wisconsin, 2001-2015. ( 28683059 )
2017
36
Babesiosis: An unusual cause of sepsis after kidney transplantation and review of the literature. ( 28636757 )
2017
37
Transfusion-transmitted babesiosis leading to severe hemolysis in two patients with sickle cell anemia. ( 28766838 )
2017
38
An ELISA for the early diagnosis of acute canine babesiosis detecting circulating antigen of large Babesia spp. ( 28807287 )
2017
39
Acute Atraumatic Splenic Hemorrhage: Babesiosis or Acute Infectious Mononucleosis. ( 28347760 )
2017
40
Is babesiosis the most common transfusion transmitted infection in the United States of America? The answer is not simple! ( 28867527 )
2017
41
Prevalence, risk factors and vectors identification of bovine anaplasmosis and babesiosis in and around Jimma town, Southwestern Ethiopia. ( 28939494 )
2017
42
Hematologic manifestations of babesiosis. ( 28202022 )
2017
43
Acute Babesiosis in Pregnancy: A Novel Imitator of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome. ( 27275801 )
2016
44
Autochthonous babesiosis in the United Kingdom. ( 27112907 )
2016
45
Diagnosis and management of bovine babesiosis outbreaks in cattle in Punjab state. ( 28096607 )
2016
46
Transfusion-transmitted babesiosis: is it time to screen the blood supply? ( 27537475 )
2016
47
Escalations in the incidence of canine babesiosis over a period of 8A years (2006-2013) in Chennai, Tamil Nadu, India. ( 27876923 )
2016
48
Red cell exchange for a case of babesiosis. ( 27531166 )
2016
49
Closing the Brief Case: Probable Transfusion-Transmitted Babesiosis in a Transplant Recipient. ( 27935832 )
2016
50
Human Babesiosis, Bolivia, 2013. ( 27434696 )
2016

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 CD36 THBS1
2
Show member pathways
10.42 EXOC8 RAP1A
3 10.09 LRPAP1 RAP1A

GO Terms for Babesiosis

Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle GO:0045335 8.96 CD36 RAP1A
2 integral component of mitochondrial inner membrane GO:0031305 8.62 COQ2 MT-CYB

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.16 MT-CYB THBS1
2 positive regulation of reactive oxygen species metabolic process GO:2000379 8.96 CD36 THBS1
3 positive regulation of blood coagulation GO:0030194 8.62 CD36 THBS1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.16 CD36 LRPAP1
2 transforming growth factor beta binding GO:0050431 8.96 CD36 THBS1
3 low-density lipoprotein particle binding GO:0030169 8.62 CD36 THBS1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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