MCID: BBS001
MIFTS: 58

Babesiosis malady

Infectious diseases category

Summaries for Babesiosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus babesia, which reproduce in red blood cells and cause hemolytic anemia. they are transmitted by ixodid ticks or by blood transfusion. babesiosis is a zoonotic disease.

MalaCards: Babesiosis, also known as human babesiosis, is related to systemic lupus erythematosus and ehrlichiosis, and has symptoms including renal failure, obnubilation/coma/lethargia/desorientation and humour troubles/anxiety/depression/apathy/euphoria/irritability. An important gene associated with Babesiosis is RPA4 (replication protein A4, 30kDa), and among its related pathways are Post-translational modification: synthesis of GPI-anchored proteins and Metabolism. The drugs quinine and quinine sulfate and the compounds phytosphingosine and sphinganine 1-phosphate have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

CDC:3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:63 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal... more...

Aliases & Classifications for Babesiosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
babesiosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

babesiosis 8 42 10 48 60
human babesiosis 42 60
babesia parasite infection 42
infection by babesia 8
piroplasmosis 8
babesiasis 8


External Ids:

Disease Ontology8 DOID:9643
MeSH34 D001404
NCIt39 C84581
ICD9CM27 088.82
MESH via Orphanet35 D001404
ICD10 via Orphanet26 B60.0
SNOMED-CT via Orphanet57 21061004
UMLS via Orphanet61 C0004576
ICD1025 B60.0

Related Diseases for Babesiosis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Clinical Features for Babesiosis

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48Orphanet
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Symptoms:

48 (show all 32)
  • renal failure
  • obnubilation/coma/lethargia/desorientation
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • restricted joint mobility/joint stiffness/ankylosis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • blood hyperviscosity/hypercoagulability
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • anemia described as malaria-like symptoms
  • hepatomegaly/liver enlargement (excluding storage disease)
  • venous thrombosis/phlebitis/thrombophlebitis
  • heart/cardiac failure
  • angor pectoris/myocardial infarction
  • myalgia/muscular pain
  • anorexia
  • cough
  • splenomegaly
  • hepatitis/icterus/cholestasis
  • hyperhidrosis/increased sweating
  • fever/chilling
  • hemolytic anemia
  • articular/joint pain/arthralgia
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hepatocellular liver disease/hepatic failure
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • pharyngitis
  • photophobia
  • asthenia/fatigue/weakness
  • thrombocytopenia/thrombopenia
  • leukopenia/hypoleukocytosis
  • facial pain/cephalalgia/migraine

Drugs & Therapeutics for Babesiosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Babesiosis

Drug clinical trials:

Search ClinicalTrials for Babesiosis

Search NIH Clinical Center for Babesiosis

Search CenterWatch for Babesiosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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32MalaCards
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MalaCards organs/tissues related to Babesiosis:

32
Liver, Testes, Heart, Lung, Pituitary, Kidney, Whole blood, Thyroid, T cells, Endothelial

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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Sources:
50PubMed
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Articles related to Babesiosis:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Generalized alopecia with vasculitis-like changes in a dog with babesiosis. (23676299)
2013
2
Questing Dermacentor reticulatus harbouring Babesia canis DNA associated with outbreaks of canine babesiosis in the Swiss Midlands. (23571114)
2013
3
Survey of babesiosis in symptomatic dogs from Romania: occurrence of Babesia gibsoni associated with breed. (23994336)
2013
4
Bovine babesiosis in the 21st century: advances in biology and functional genomics. (23068911)
2013
5
Babesiosis. (22608122)
2012
6
Preventing transfusion-transmitted babesiosis: preliminary experience of the first laboratory-based blood donor screening program. (22452654)
2012
7
Babesiosis surveillance - 18 States, 2011. (22785341)
2012
8
Transfusion-associated babesiosis in the United States: a description of cases. (21893613)
2011
9
Emerging incidence of Lyme borreliosis, babesiosis, bartonellosis, and granulocytic ehrlichiosis in Australia. (22267937)
2011
10
Congenital babesiosis in a four-week-old female infant. (20118748)
2010
11
Canine babesiosis. (20933141)
2010
12
Red cell exchange transfusion for babesiosis in Rhode Island. (19291782)
2009
13
Babesiosis: another tick-borne disease. (19474614)
2009
14
Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus casei. (19120190)
2008
15
Detection of bovine babesiosis in Mozambique by a novel seminested hot-start PCR method. (18329810)
2008
16
Productivity and health effects of anaplasmosis and babesiosis on Bos indicus cattle and their crosses, and the effects of differing intensity of tick control in Australia. (18472219)
2008
17
Epidemiologic features of human babesiosis in Wisconsin, 1996-2005. (17844708)
2007
18
Atovaquone and azithromycin treatment for babesiosis in an infant. (17259886)
2007
19
Development of two immunochromatographic tests for the serodiagnosis of bovine babesiosis. (17590275)
2007
20
Seroprevalence of canine babesiosis in Hungary suggesting breed predisposition. (16715235)
2006
21
Transfusion-acquired babesiosis in a nonendemic area. (15916297)
2005
22
Vaccination against canine babesiosis. (15780840)
2005
23
Inhibitory effect of pyrimidine and purine nucleotides on the multiplication of Babesia gibsoni: possible cause of low parasitemia and simultaneous reticulocytosis in canine babesiosis. (15133268)
2004
24
Risk and prevention of transfusion-transmitted babesiosis and other tick-borne diseases. (14564169)
2003
25
Molecular characterization of a non-Babesia divergens organism causing zoonotic babesiosis in Europe. (12967491)
2003
26
Renal involvement in dogs with babesiosis. (11563713)
2001
27
Laboratory diagnosis of ehrlichiosis and babesiosis. (11332670)
2001
28
Septic shock due to babesiosis. (11477535)
2001
29
Attenuated trivalent vaccine against babesiosis and anaplasmosis in Colombia. (11193685)
2000
30
A cluster of transfusion-associated babesiosis cases traced to a single asymptomatic donor. (10078490)
1999
31
Diagnosis of canine babesiosis by Percoll gradient separation of parasitized erythrocytes. (9925223)
1999
32
Southern extension of the range of human babesiosis in the eastern United States. (10325378)
1999
33
Persistent parasitemia after acute babesiosis. (9664092)
1998
34
Life-threatening babesiosis in an asplenic patient treated with exchange transfusion, azithromycin, and atovaquone. (9835673)
1998
35
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in Malawi. (9203307)
1997
36
Antibodies to multiple tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in white-footed mice. (9249691)
1997
37
Duration of protective immunity in experimental canine babesiosis after homologous and heterologous challenge. (9066051)
1997
38
The effect of diminazene aceturate on cholinesterase activity in dogs with canine babesiosis. (9561493)
1997
39
Studies on buffalo babesiosis in Hubei Province, China. (9512742)
1997
40
Spread of lymphatic filariasis, re-emergence of leishmaniasis &amp; threat of babesiosis in India. (8926027)
1996
41
Use of polymerase chain reaction in bovine babesiosis research. (8784529)
1996
42
Prophylactic treatment of experimental canine babesiosis (Babesia canis) with doxycycline. (9017887)
1996
43
Babesiosis in a six-day-old calf. (8903013)
1996
44
Human babesiosis. (8978977)
1996
45
Electrophoretic separation of canine haemoglobin in dogs with babesiosis. (8691410)
1995
46
Large scale survey of bovine babesiosis due to Babesia divergens in France. (7709570)
1995
47
Cerebellar ataxia as a possible complication of babesiosis in two dogs. (7595921)
1994
48
Human babesiosis in New York State: an epidemiological description of 136 cases. (1457632)
1992
49
Studies on the use of gerbil-derived Babesia divergens antigen for diagnosis of bovine babesiosis. (1957482)
1991
50
Epidemiology of bovine babesiosis and anaplasmosis in Zambia. (3070875)
1988

Genetic Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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53Reactome, 29KEGG
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Compounds for genes affiliated with Babesiosis

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank
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Compounds related to Babesiosis according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1phytosphingosine44 2410.7PIGW, PIGM, PIGL, PIGV
2sphinganine 1-phosphate44 2410.7PIGV, PIGL, PIGM, PIGW
3sphinganine44 2410.7PIGV, PIGL, PIGM, PIGW
4sphingosine 1-phosphate28 2410.6PIGW, PIGM, PIGL, PIGV
5dihydroceramide44 2410.6PIGV, PIGL, PIGM, PIGW
6glucosylceramide44 2410.6PIGV, PIGL, PIGM, PIGW
7phosphatidylinositol-3,4,5-trisphosphate44 2410.6PIGW, PIGM, PIGL, PIGV
8sphingosine44 11 2411.5PIGV, PIGL, PIGM, PIGW
9ascorbic acid44 2410.1HSPA4, CRP, MT-CYB, TPO
10iron44 2410.1TPO, MT-CYB, CRP, HSPA4
11asparagine449.0MT-CYB, RAP1A, TPO
12fibrinogen449.0TPO, MASP1, CRP, HSPA4

GO Terms for genes affiliated with Babesiosis

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16Gene Ontology
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Cellular components related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.2DPM1, PIGW, PIGM, PIGL, PIGV

Biological processes related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1GPI anchor biosynthetic processGO:0065069.8DPM1, PIGL, PIGV
2preassembly of GPI anchor in ER membraneGO:0162549.4PIGV, PIGL, PIGM, PIGW
3C-terminal protein lipidationGO:0065019.3DPM1, PIGW, PIGM, PIGL, PIGV
4post-translational protein modificationGO:0436878.9PIGV, PIGL, PIGM, PIGW, DPM1
5cellular protein metabolic processGO:0442677.6RPLP2, CCT7, EXOC8, PIGV, PIGL, PIGM

Molecular functions related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mannosyltransferase activityGO:00003010.0PIGM, PIGV

Products for genes affiliated with Babesiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Babesiosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet