MCID: BBS001
MIFTS: 45

Babesiosis malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Babesiosis

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Sources:
2CDC, 11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Babesiosis:

Name: Babesiosis 11 47 53 2 38 13 67
Human Babesiosis 47 67
Babesia Parasite Infection 47
 
Infection by Babesia 11
Piroplasmosis 11
Babesiasis 11

Characteristics:

Orphanet epidemiological data:

53
babesiosis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult

Classifications:



External Ids:

Disease Ontology11 DOID:9643
ICD1029 B60.0
ICD9CM31 088.82
MeSH38 D001404
NCIt44 C84581
Orphanet53 ORPHA108
UMLS via Orphanet68 C0004576
MESH via Orphanet39 D001404
ICD10 via Orphanet30 B60.0

Summaries for Babesiosis

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Disease Ontology:11 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

MalaCards based summary: Babesiosis, also known as human babesiosis, is related to tick infestation and lyme disease, and has symptoms including hemolytic anemia, migraine and abnormality of temperature regulation. An important gene associated with Babesiosis is CD36 (CD36 Molecule), and among its related pathways are Malaria and Reelin signaling pathway. The drugs quinine and quinine sulfate have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and pituitary.

CDC:2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:70 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of Apicomplexa.... more...

Related Diseases for Babesiosis

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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms for Babesiosis

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Symptoms:

 11
  • anemia described as malaria-like symptoms

Human phenotypes related to Babesiosis:

 63 53 (show all 37)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hemolytic anemia63 53 hallmark (90%) Very frequent (99-80%) HP:0001878
2 migraine63 hallmark (90%) HP:0002076
3 abnormality of temperature regulation63 hallmark (90%) HP:0004370
4 hyperhidrosis63 53 typical (50%) Frequent (79-30%) HP:0000975
5 splenomegaly63 53 typical (50%) Frequent (79-30%) HP:0001744
6 thrombocytopenia63 53 typical (50%) Frequent (79-30%) HP:0001873
7 leukopenia63 53 typical (50%) Frequent (79-30%) HP:0001882
8 anorexia63 53 typical (50%) Occasional (29-5%) HP:0002039
9 hepatomegaly63 53 typical (50%) Frequent (79-30%) HP:0002240
10 arthralgia63 53 typical (50%) Frequent (79-30%) HP:0002829
11 myalgia63 53 typical (50%) Frequent (79-30%) HP:0003326
12 renal insufficiency63 53 occasional (7.5%) Occasional (29-5%) HP:0000083
13 photophobia63 53 occasional (7.5%) Occasional (29-5%) HP:0000613
14 limitation of joint mobility63 53 occasional (7.5%) Occasional (29-5%) HP:0001376
15 hepatic failure63 53 occasional (7.5%) Occasional (29-5%) HP:0001399
16 congestive heart failure63 53 occasional (7.5%) Occasional (29-5%) HP:0001635
17 coronary artery disease63 occasional (7.5%) HP:0001677
18 weight loss63 occasional (7.5%) HP:0001824
19 nausea and vomiting63 53 occasional (7.5%) Occasional (29-5%) HP:0002017
20 respiratory insufficiency63 53 occasional (7.5%) Occasional (29-5%) HP:0002093
21 reduced consciousness/confusion63 occasional (7.5%) HP:0004372
22 thrombophlebitis63 occasional (7.5%) HP:0004418
23 hypercoagulability63 53 occasional (7.5%) Occasional (29-5%) HP:0100724
24 recurrent pharyngitis63 53 occasional (7.5%) Occasional (29-5%) HP:0100776
25 depression53 Occasional (29-5%)
26 jaundice53 Frequent (79-30%)
27 coma53 Occasional (29-5%)
28 confusion53 Occasional (29-5%)
29 myocardial infarction53 Occasional (29-5%)
30 clinodactyly of the 5th toe53 Occasional (29-5%)
31 fever53 Very frequent (99-80%)
32 headache53 Very frequent (99-80%)
33 recurrent infections53 Frequent (79-30%)
34 venous thrombosis53 Occasional (29-5%)
35 disseminated intravascular coagulation53 Occasional (29-5%)
36 fatigue53 Frequent (79-30%)
37 cough53 Frequent (79-30%)

Drugs & Therapeutics for Babesiosis

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Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 36045
2AntibodiesPhase 36045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Babesia Testing in Blood DonorsCompletedNCT01528449Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS67/NDF-RT45:


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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MalaCards organs/tissues related to Babesiosis:

35
Testes, Heart, Pituitary, T cells, Endothelial, Thyroid, Kidney

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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Articles related to Babesiosis:

(show top 50)    (show all 591)
idTitleAuthorsYear
1
First Report of Babesia microti-Caused Babesiosis in Spain. (27560451)
2016
2
Babesiosis and other protists causing systemic infection. (26629447)
2015
3
A Study of Naturally Acquired Canine Babesiosis Caused by Single and Mixed Babesia Species in Zambia: Clinicopathological Findings and Case Management. (26682062)
2015
4
A retrospective serological survey on human babesiosis in Belgium. (25636942)
2015
5
Screening for babesiosis: where is the policy? (25212423)
2014
6
Diagnostic methods used to monitor an outbreak of babesiosis (Babesia bovis) in a herd of feral cattle in New Caledonia. (23718796)
2013
7
Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France. (23448544)
2013
8
Babesiosis in a recently imported cat. (23264391)
2012
9
Babesiosis among elderly Medicare beneficiaries, United States, 2006-2008. (22257500)
2012
10
Babesiosis. (22608122)
2012
11
Persistent babesiosis in a stem cell transplant recipient. (21185598)
2011
12
Why is Southern African canine babesiosis so virulent? An evolutionary perspective. (21489239)
2011
13
Clinical management of canine babesiosis. (20230437)
2010
14
Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections. (20377861)
2010
15
Babesiosis in the immediate postoperative period after splenectomy for trauma. (19622029)
2009
16
Fatality despite appropriate treatment for babesiosis. (19500034)
2009
17
Babesiosis in Italy: an overview. (17691603)
2007
18
Seroprevalence of canine babesiosis in Hungary suggesting breed predisposition. (16715235)
2006
19
Babesiosis of wild carnivores and ungulates. (16500026)
2006
20
Haematuria due to babesiosis. (15938562)
2005
21
Cardiac involvement in canine babesiosis. (15900893)
2005
22
Glucose, lactate, and pyruvate concentrations in dogs with babesiosis. (15757122)
2005
23
Babesiosis: An Update on Epidemiology and Treatment. (12525291)
2003
24
Risk and prevention of transfusion-transmitted babesiosis and other tick-borne diseases. (14564169)
2003
25
Naturally acquired babesiosis in a reindeer (Rangifer tarandus tarandus) herd in Great Britain. (12541061)
2003
26
Life-threatening hypotension from babesiosis hemolysis. (12098187)
2002
27
Babesiosis. (11982307)
2002
28
Blood pressure changes in dogs with babesiosis. (10949511)
2000
29
Detection of enzootic babesiosis in baboons (Papio cynocephalus) and phylogenetic evidence supporting synonymy of the genera Entopolypoides and Babesia. (10203519)
1999
30
Concurrent babesiosis and Lyme disease diagnosed in Ontario. (9659788)
1998
31
Do babesiosis and malaria share a common disease process? (9683899)
1998
32
Bovine babesiosis and anaplasmosis follow-up on cattle relocated in an endemic area for hemoparasitic diseases. (9668444)
1998
33
Human babesiosis. (9683900)
1998
34
Canine babesiosis in South Africa: more than one disease. Does this serve as a model for falciparum malaria? (9683901)
1998
35
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in Malawi. (9203307)
1997
36
Cross-sectional estimation of Babesia bovis antibody prevalence in an area of Argentina used for extensive cattle breeding as an aid to control babesiosis. (9234418)
1997
37
Babesiosis. (8729197)
1996
38
Spread of lymphatic filariasis, re-emergence of leishmaniasis & threat of babesiosis in India. (8926027)
1996
39
Use of polymerase chain reaction in bovine babesiosis research. (8784529)
1996
40
Acute fulminating babesiosis in hamsters infected with Babesia microti. (8875313)
1996
41
Current state and future trends in the diagnosis of babesiosis. (7597794)
1995
42
Molecular basis for vaccine development against anaplasmosis and babesiosis. (7597787)
1995
43
The level of infestation with the vector of cattle babesiosis in Argentina. (1343682)
1992
44
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992
45
Estimation of the potential demand for a bovine babesiosis and anaplasmosis vaccine in Argentina. (2382381)
1990
46
Effect of dexamethosone on babesiosis in Tatera indica (Hardwicke). (16414662)
1990
47
Tick-borne diseases of cattle in Paraguay. I. Seroepidemiological studies on anaplasmosis and babesiosis. (2321261)
1990
48
Bovine babesiosis on Nevis--implications for tick control. (2368265)
1990
49
Babesiosis, asplenia, and AIDS. (1975291)
1990
50
Human babesiosis--a preliminary report of 2 suspected cases in South Africa. (2251622)
1990

Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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Pathways related to Babesiosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9CD36, THBS1
29.7LRPAP1, RAP1A

GO Terms for genes affiliated with Babesiosis

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Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of reactive oxygen species metabolic processGO:200037910.2CD36, THBS1
2response to calcium ionGO:00515929.8MT-CYB, THBS1
3positive regulation of blood coagulationGO:00301949.8CD36, THBS1
4receptor-mediated endocytosisGO:00068989.1CD36, LRPAP1, MASP1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:00504319.9CD36, THBS1
2low-density lipoprotein particle bindingGO:00301699.9CD36, THBS1

Sources for Babesiosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet