MCID: BBS001
MIFTS: 61

Babesiosis malady

Rare diseases, Infectious diseases categories

Summaries for Babesiosis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A parasitic protozoa infectious disease that has symptommild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus babesia, which reproduce in red blood cells and cause hemolytic anemia. they are transmitted by ixodid ticks or by blood transfusion. babesiosis is a zoonotic disease.

MalaCards: Babesiosis, also known as human babesiosis, is related to ehrlichiosis and lyme disease, and has symptoms including thrombocytopenia/thrombopenia, hemolytic anemia and facial pain/cephalalgia/migraine. An important gene associated with Babesiosis is RPA4 (replication protein A4, 30kDa), and among its related pathways is Post-translational modification- synthesis of GPI-anchored proteins. The drugs quinine and quinine sulfate and the compounds ketamine and Ganglioside GT1b (d18:0/22:1(13Z)) have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and heart.

CDC:4 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.

Wikipedia:66 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a genus of protozoal... more...

Aliases & Classifications for Babesiosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 50Orphanet, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
babesiosis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

babesiosis 9 44 11 50 63
human babesiosis 44 63
babesia parasite infection 44
infection by babesia 9
piroplasmosis 9
babesiasis 9


External Ids:

Disease Ontology9 DOID:9643
MeSH36 D001404
NCIt41 C84581
ICD9CM28 088.82
MESH via Orphanet37 D001404
ICD10 via Orphanet27 B60.0
SNOMED-CT via Orphanet60 21061004
UMLS via Orphanet64 C0004576
ICD1026 B60.0

Related Diseases for Babesiosis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to babesiosis

Symptoms for Babesiosis

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50Orphanet
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Symptoms:

50 (show all 32)
  • thrombocytopenia/thrombopenia
  • hemolytic anemia
  • facial pain/cephalalgia/migraine
  • anorexia
  • pharyngitis
  • hemorrhage/hemorrhagic syndrome/excessive/long-lasting bleeding
  • leukopenia/hypoleukocytosis
  • blood hyperviscosity/hypercoagulability
  • anemia described as malaria-like symptoms
  • hepatomegaly/liver enlargement (excluding storage disease)
  • venous thrombosis/phlebitis/thrombophlebitis
  • angor pectoris/myocardial infarction
  • myalgia/muscular pain
  • photophobia
  • obnubilation/coma/lethargia/desorientation
  • restricted joint mobility/joint stiffness/ankylosis
  • splenomegaly
  • early death/lethality
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • humour troubles/anxiety/depression/apathy/euphoria/irritability
  • hyperhidrosis/increased sweating
  • asthenia/fatigue/weakness
  • renal failure
  • cough
  • heart/cardiac failure
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • hepatocellular liver disease/hepatic failure
  • hepatitis/icterus/cholestasis
  • immunodeficiency/increased susceptibility to infections/recurrent infections
  • articular/joint pain/arthralgia
  • fever/chilling
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Babesiosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Babesiosis

Drug clinical trials:

Search ClinicalTrials for Babesiosis

Search NIH Clinical Center for Babesiosis

Search CenterWatch for Babesiosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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34MalaCards
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MalaCards organs/tissues related to Babesiosis:

34
Liver, Testes, Heart, Lung, Pituitary, Kidney, T cells, Endothelial, Whole blood, Thyroid

Animal Models for Babesiosis or affiliated genes

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Publications for Babesiosis

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53PubMed
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Articles related to Babesiosis:

(show top 50)    (show all 488)
idTitleAuthorsYear
1
Diagnostic methods used to monitor an outbreak of babesiosis (Babesia bovis) in a herd of feral cattle in New Caledonia. (23718796)
2013
2
Generalized alopecia with vasculitis-like changes in a dog with babesiosis. (23676299)
2013
3
Questionnaire-based survey on distribution and clinical incidence of canine babesiosis in France. (23448544)
2013
4
Babesiosis in a recently imported cat. (23264391)
2012
5
Human babesiosis. (22970965)
2012
6
Babesiosis in an Egyptian boy aquired from pet dog, and a general review. (21634246)
2011
7
Transfusion-associated babesiosis in the United States: a description of cases. (21893613)
2011
8
Persistent babesiosis in a stem cell transplant recipient. (21185598)
2011
9
Why is Southern African canine babesiosis so virulent? An evolutionary perspective. (21489239)
2011
10
Clinical management of canine babesiosis. (20230437)
2010
11
Canine babesiosis in northern Portugal and molecular characterization of vector-borne co-infections. (20377861)
2010
12
Efficacy of Ixodes ricinus as a vector of zoonotic babesiosis in Sinai Peninsula, Egypt. (21246957)
2010
13
Babesiosis in the immediate postoperative period after splenectomy for trauma. (19622029)
2009
14
Fatality despite appropriate treatment for babesiosis. (19500034)
2009
15
Preliminary evaluation of the BrEMA1 gene as a tool for associating babesia rossi genotypes and clinical manifestation of canine Babesiosis. (19741079)
2009
16
Enhancement of the Mexican bovine babesiosis vaccine efficacy by using Lactobacillus casei. (19120190)
2008
17
Causative agents of canine babesiosis in Brazil. (17980446)
2008
18
The case of babesiosis in farmed wolf (Canis lupus L). (19055068)
2008
19
Canine babesiosis: a Brazilian perspective. (16962707)
2006
20
Haematuria due to babesiosis. (15938562)
2005
21
The impact of 2 dipping systems on endemic stability to bovine babesiosis and anaplasmosis in cattle in 4 communally grazed areas in Limpopo Province, South Africa. (16642719)
2005
22
Cardiac involvement in canine babesiosis. (15900893)
2005
23
Babesiosis: An Update on Epidemiology and Treatment. (12525291)
2003
24
Risk and prevention of transfusion-transmitted babesiosis and other tick-borne diseases. (14564169)
2003
25
Life-threatening hypotension from babesiosis hemolysis. (12098187)
2002
26
Lipid abnormalities in babesiosis. (10946820)
2000
27
Cloned lines of Babesia bovis differ in their ability to induce cerebral babesiosis in cattle. (10894468)
2000
28
Blood pressure changes in dogs with babesiosis. (10949511)
2000
29
Atovaquone and azithromycin for the treatment of babesiosis. (11078770)
2000
30
Detection of enzootic babesiosis in baboons (Papio cynocephalus) and phylogenetic evidence supporting synonymy of the genera Entopolypoides and Babesia. (10203519)
1999
31
Concurrent babesiosis and Lyme disease diagnosed in Ontario. (9659788)
1998
32
Do babesiosis and malaria share a common disease process? (9683899)
1998
33
Immunisation of smallholder dairy cattle against anaplasmosis and babesiosis in Malawi. (9203307)
1997
34
Response of babesiosis to a combined regimen of quinine and azithromycin. (9196774)
1997
35
Babesiosis in a patient with sickle cell anemia. (9217625)
1997
36
Cross-sectional estimation of Babesia bovis antibody prevalence in an area of Argentina used for extensive cattle breeding as an aid to control babesiosis. (9234418)
1997
37
Babesiosis. (8729197)
1996
38
Spread of lymphatic filariasis, re-emergence of leishmaniasis &amp; threat of babesiosis in India. (8926027)
1996
39
Use of polymerase chain reaction in bovine babesiosis research. (8784529)
1996
40
Acute fulminating babesiosis in hamsters infected with Babesia microti. (8875313)
1996
41
Current state and future trends in the diagnosis of babesiosis. (7597794)
1995
42
The level of infestation with the vector of cattle babesiosis in Argentina. (1343682)
1992
43
Fatal acute babesiosis in a juvenile wild dog (Lycaon pictus). (1569540)
1992
44
Haematology of experimental babesiosis and ehrlichiosis in steroid immunosuppressed horses. (1519411)
1992
45
Estimation of the potential demand for a bovine babesiosis and anaplasmosis vaccine in Argentina. (2382381)
1990
46
Effect of dexamethosone on babesiosis in Tatera indica (Hardwicke). (16414662)
1990
47
Tick-borne diseases of cattle in Paraguay. I. Seroepidemiological studies on anaplasmosis and babesiosis. (2321261)
1990
48
Bovine babesiosis on Nevis--implications for tick control. (2368265)
1990
49
Concurrent babesiosis and ehrlichiosis in the dog: blood smear examination supplemented by the indirect fluorescent antibody test, using Cowdria ruminantium as antigen. (2234860)
1990
50
The impact of cultural and environmental changes on the epidemiology and control of human babesiosis. (2696158)
1989

Variations for Babesiosis

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Expression for genes affiliated with Babesiosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for genes affiliated with Babesiosis

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51PathCards, 56Reactome, 31KEGG
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Pathways related to Babesiosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4PIGL, PIGW

Compounds for genes affiliated with Babesiosis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB
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Compounds related to Babesiosis according to GeneCards/GeneDecks:

(show top 50)    (show all 517)
idCompoundScoreTop Affiliating Genes
1ketamine46 30 1211.9CRP, HSPA4
2Ganglioside GT1b (d18:0/22:1(13Z))259.9PIGL, PIGW
3Ganglioside GT1b (d18:0/23:0)259.9PIGL, PIGW
4Ganglioside GT1b (d18:1/22:1(13Z))259.9PIGL, PIGW
5Ganglioside GT1b (d18:1/23:0)259.9PIGL, PIGW
6Ganglioside GT1b (d18:1/24:0)259.9PIGL, PIGW
7Ganglioside GT1b (d18:0/22:0)259.9PIGW, PIGL
8Ganglioside GQ1c (d18:1/22:1(13Z))259.9PIGW, PIGL
9Ganglioside GQ1c (d18:0/18:1(9Z))259.9PIGW, PIGL
10Ganglioside GQ1c (d18:0/20:0)259.9PIGL, PIGW
11Ganglioside GQ1c (d18:0/22:0)259.9PIGL, PIGW
12Ganglioside GQ1c (d18:1/20:0)259.9PIGL, PIGW
13Ganglioside GQ1c (d18:1/22:0)259.9PIGL, PIGW
14Ganglioside GT1c (d18:0/23:0)259.9PIGL, PIGW
15Ganglioside GT1c (d18:0/24:0)259.9PIGL, PIGW
16Ganglioside GT2 (d18:0/25:0)259.9PIGW, PIGL
17Ganglioside GT2 (d18:1/25:0)259.9PIGL, PIGW
18Ganglioside GT2 (d18:1/26:0)259.8PIGL, PIGW
19Ganglioside GT3 (d18:0/26:0)259.8PIGL, PIGW
20Ganglioside GT3 (d18:0/26:1(17Z))259.8PIGL, PIGW
21Ganglioside GT3 (d18:1/26:1(17Z))259.8PIGL, PIGW
22Ganglioside GT2 (d18:0/24:1(15Z))259.8PIGW, PIGL
23Ganglioside GT1c (d18:0/24:1(15Z))259.8PIGL, PIGW
24Ganglioside GT1c (d18:1/24:0)259.8PIGL, PIGW
25Ganglioside GT1c (d18:1/24:1(15Z))259.8PIGL, PIGW
26Ganglioside GT1c (d18:1/25:0)259.8PIGL, PIGW
27Ganglioside GD1a (d18:0/22:0)259.8PIGL, PIGW
28Ganglioside GD1b (d18:0/23:0)259.8PIGW, PIGL
29Ganglioside GD1b (d18:0/24:0)259.8PIGL, PIGW
30Ganglioside GD1b (d18:0/24:1(15Z))259.8PIGL, PIGW
31Ganglioside GD1b (d18:1/24:0)259.8PIGL, PIGW
32Ganglioside GD1b (d18:1/24:1(15Z))259.8PIGL, PIGW
33Ganglioside GD1b (d18:1/25:0)259.8PIGL, PIGW
34Ganglioside GD1a (d18:1/24:0)259.8PIGW, PIGL
35Ganglioside GD1a (d18:0/22:1(13Z))259.7PIGL, PIGW
36Ganglioside GD1a (d18:0/23:0)259.7PIGL, PIGW
37Ganglioside GD1a (d18:1/22:1(13Z))259.7PIGL, PIGW
38Ganglioside GD1a (d18:1/23:0)259.7PIGL, PIGW
39Ganglioside GD2 (d18:0/24:1(15Z))259.7PIGL, PIGW
40Ganglioside GD3 (d18:0/26:1(17Z))259.7PIGL, PIGW
41Ganglioside GM3 (d18:0/18:0)259.7PIGL, PIGW
42Ganglioside GM3 (d18:0/18:1(11Z))259.6PIGL, PIGW
43Ganglioside GM3 (d18:0/18:1(9Z))259.6PIGL, PIGW
44Ganglioside GM3 (d18:1/18:1(11Z))259.6PIGL, PIGW
45Ganglioside GD3 (d18:0/26:0)259.6PIGW, PIGL
46Ganglioside GD2 (d18:0/25:0)259.5PIGL, PIGW
47Ganglioside GD2 (d18:0/26:0)259.4PIGL, PIGW
48Ganglioside GD2 (d18:1/9Z-18:1)259.4PIGL, PIGW
49Ganglioside GD2 (d18:1/26:0)259.3PIGL, PIGW
50Ganglioside GD2 (d18:1/26:1(15Z))259.1PIGL, PIGW

GO Terms for genes affiliated with Babesiosis

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17Gene Ontology
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Biological processes related to Babesiosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-terminal protein lipidationGO:0065019.4PIGL, PIGW
2preassembly of GPI anchor in ER membraneGO:0162549.1PIGL, PIGW

Products for genes affiliated with Babesiosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Babesiosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet