MCID: BCK006
MIFTS: 46

Back Pain malady

Summaries for Back Pain

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 If you've ever groaned, "oh, my aching back!", you are not alone. back pain is one of the most common medical problems, affecting 8 out of 10 people at some point during their lives. back pain can range from a dull, constant ache to a sudden, sharp pain. acute back pain comes on suddenly and usually lasts from a few days to a few weeks. back pain is called chronic if it lasts for more than three months. most back pain goes away on its own, though it may take awhile. taking over-the-counter pain relievers and resting can help. however, staying in bed for more than 1 or 2 days can make it worse. if your back pain is severe or doesn't improve after three days, you should call your health care provider. you should also get medical attention if you have back pain following an injury. treatment for back pain depends on what kind of pain you have, and what is causing it. it may include hot or cold packs, exercise, medicines, injections, complementary and alternative treatments, and sometimes surgery. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Back Pain is related to spinal stenosis and degenerative disc disease. An important gene associated with Back Pain is FABP4 (fatty acid binding protein 4, adipocyte), and among its related pathways are Folate biosynthesis and Protein digestion and absorption. The compounds estrogen and procollagen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node.

NINDS:44 Acute or short-term low back pain generally lasts from a few days to a few weeks. Most acute back pain is the result of trauma to the lower back or a disorder such as arthritis. Pain from trauma may be caused by a sports injury, work around the house or in the garden, or a sudden jolt such as a car accident or other stress on spinal bones and tissues. Symptoms may range from muscle ache to shooting or stabbing pain, limited flexibility and range of motion, or an inability to stand straight. Chronic back pain is pain that persists for more than 3 months. It is often progressive and the cause can be difficult to determine.

Wikipedia:64 Back pain is pain felt in the back that usually originates from the muscles, nerves, bones, joints or... more...

Aliases & Classifications for Back Pain

Sources:
44NINDS, 34MedlinePlus
See all sources

Aliases & Descriptions:

back pain 44 34


Related Diseases for Back Pain

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Back Pain:



Diseases related to back pain

Clinical Features for Back Pain

Drugs & Therapeutics for Back Pain

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Back Pain

Drug clinical trials:

Search ClinicalTrials for Back Pain

Search NIH Clinical Center for Back Pain

Highlights from CenterWatch's Drugs in Clinical Trials Database for Back Pain:

idCompanyCompoundMechanismPhase
1ISTO TechnologiesNuQuJuvenile cartilage cellsII
2MesoblastMesenchymal Precursor CellsAdult stem cell technology derived from adult Mesenchymal Precursor CellsII

Genetic Tests for Back Pain

Anatomical Context for Back Pain

Sources:
33MalaCards
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MalaCards organs/tissues related to Back Pain:

33
Bone marrow, Whole blood, Lymph node, Brain, Cortex, Spinal cord, Heart, Skeletal muscle, Breast, Skin, Prostate, Myeloid, Monocytes, B cells, Temporal lobe, Adrenal cortex, Pituitary

Animal Models for Back Pain or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Back Pain

Sources:
51PubMed
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Articles related to Back Pain:

(show top 50)    (show all 769)
idTitleAuthorsYear
1
Prevalence of Low Back Pain in Adolescent Athletes - an Epidemiological Investigation. (24424960)
2014
2
The within-session change in low back pain intensity following spinal manipulative therapy is related to differences in diffusion of water in the intervertebral discs of the upper lumbar spine and L5-s1. (24261925)
2014
3
Back pain in tennis players: a link with lumbar serve kinematics and range of motion. (23877374)
2014
4
The Impact of Buprenorphine Transdermal Delivery System on Activities of Daily Living Among Patients with Chronic Low Back Pain: An Application of the International Classification of Functioning, Disability and Health. (24394747)
2014
5
Gadolinium contrast-enhanced MRI sequence does not have an incremental value in the assessment of sacroiliitis in patients with early inflammatory back pain by using MRI in combination with pelvic radiographs: a 2-year follow-up study. (24428976)
2014
6
Determining the pain-affecting factors of university students with nonspecific low back pain. (24409020)
2013
7
The Role of Sacrolumbar Fat Grafting in the Treatment of Spinal Fusion Instrumentation-Related Chronic Low Back Pain: A Preliminary Report. (24299726)
2013
8
The Effects of Stabilization and Mckenzie Exercises on Transverse Abdominis and Multifidus Muscle Thickness, Pain, and Disability: A Randomized Controlled Trial in NonSpecific Chronic Low Back Pain. (24409016)
2013
9
A web-based intervention to improve and prevent low back pain among office workers: a randomized controlled trial. (23930271)
2013
10
In Response: Re: the letter by dr. Almosnino, regarding our published article "Which Instruments can Detect Submaximal Physical and Functional Capacity in Patients With Chronic Nonspecific Back Pain? A Systematic Review" (24384654)
2013
11
Post-partum low-back pain of an uncommon origin: a case report. (23948818)
2013
12
Spinal Manipulative Therapy-Specific Changes in Pain Sensitivity in Individuals With Low Back Pain (NCT01168999). (24361109)
2013
13
Prevalence and clinical importance of alternative causes of symptoms using a renal colic computed tomography protocol in patients with flank or back pain and absence of pyuria. (23672361)
2013
14
Radiofrequency treatment has a beneficial role in reducing low back pain due to facet syndrome in octogenarians or older. (23818771)
2013
15
An unusual case of epigastric and back pain: expanding descending thoracic aneurysm resulting from tertiary syphilis diagnosed with positron emission tomography. (24254483)
2013
16
Inefficiencies in osteoarthritis and chronic low back pain management. (24304160)
2013
17
The value of pain coping constructs in subcategorising back pain patients according to risk of poor outcome. (24260746)
2013
18
Ruptured temporal lobe arachnoid cyst presenting with severe back pain. (23829378)
2013
19
The effectiveness of massage therapy for the treatment of nonspecific low back pain: a systematic review of systematic reviews. (24043951)
2013
20
Acute schmorl node in dorsal spine: an unusual cause of a sudden onset of severe back pain in a young female. (23741552)
2013
21
Trunk bend and twist coordination is affected by low back pain status during running. (24313829)
2013
22
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of the extended-release tramadol hydrochloride/acetaminophen fixed-dose combination tablet for the treatment of chronic low back pain. (24183364)
2013
23
One-year outcomes of surgical versus nonsurgical treatments for discogenic back pain: a community-based prospective cohort study. (23890947)
2013
24
Authors' Response to "Acupuncture for Chronic Back Pain: The Mysterious Case of the Excluded Data" (24299713)
2013
25
Should physical activity recommendation depend on state of low back pain? (24115569)
2013
26
Exploring the Longitudinal Stability of the CSQ24 in a Back Pain Population. (24320945)
2013
27
Face-to-face information combined with a booklet versus a booklet alone for treatment of mild low-back pain: a randomized controlled study. (24185642)
2013
28
Back pain in a previously healthy teenager. (23867883)
2013
29
A Closer Examination of the Interaction Among Risk Factors for Low Back Pain. (24200334)
2013
30
Estimates of annual medical costs of work-related low back pain in Japan. (23955653)
2013
31
Should We Start Treating Chronic Low Back Pain with Antibiotics Rather than with Pain Medications? (24155998)
2013
32
Comparison of spinal fusion and nonoperative treatment in patients with chronic low back pain: long-term follow-up of three randomized controlled trials. (24200413)
2013
33
Acupuncture treatment of chronic low back pain reverses an abnormal brain default mode network in correlation with clinical pain relief. (24280949)
2013
34
Thrust and nonthrust manipulation for older adults with low back pain: an evaluation of pain and disability. (23769265)
2013
35
Spinal cord stimulation for predominant low back pain in failed back surgery syndrome: study protocol for an international multicenter randomized controlled trial (PROMISE study). (24195916)
2013
36
Utility of single photon emission computed tomography/computed tomography imaging in evaluation of chronic low back pain. (23919068)
2012
37
Prevalence, Spinal Alignment, and Mobility of Lumbar Spinal Stenosis with or without Chronic Low Back Pain: A Community-Dwelling Study. (22110922)
2011
38
Familial hypophosphatemia: an unusual presentation with low back ache, heel pain, and a limp in a young man, and literature review. (21042824)
2011
39
Botulinum type A toxin complex for the relief of upper back myofascial pain syndrome: how do fixed-location injections compare with trigger point-focused injections? (21692970)
2011
40
Progression of low back and lower extremity pain in a cohort of patients with achondroplasia. (20809726)
2010
41
Injection treatment and back pain associated with degenerative lumbar spinal stenosis in older adults. (21102972)
2010
42
The preliminary results of a comparative effectiveness evaluation of adhesiolysis and caudal epidural injections in managing chronic low back pain secondary to spinal stenosis: a randomized, equivalence controlled trial. (19935991)
2009
43
Disc height and lumbar index as independent predictors of degenerative spondylolisthesis in middle-aged women with low back pain. (19478661)
2009
44
Cauda equina syndrome in a pregnant woman referred to physical therapy for low back pain. (18978454)
2008
45
Medicare Evidence Development and Coverage Advisory Committee Meeting on lumbar fusion surgery for treatment of chronic back pain from degenerative disc disease. (18090077)
2007
46
Thoracic osteoporotic fracture without upper back pain. (15314538)
2004
47
Idiopathic juvenile osteoporosis. An unusual cause of back pain in an adolescent. (8581446)
1995
48
Fibrinolytic defect in chronic back pain. A controlled study of plasminogen activator activity in 20 patients. (1835242)
1991
49
Fever and painful plaques on the face, back, and extremities. Acute febrile neutrophilic dermatosis (Sweet's syndrome). (2673050)
1989
50
Idiopathic dissecting aortic aneurysm associated with pain in the back in an adolescent. Report of a case. (2972726)
1988

Genetic Variations for Back Pain

Expression for genes affiliated with Back Pain

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Back Pain

Search GEO for disease gene expression data for Back Pain.

Pathways for genes affiliated with Back Pain

Sources:
30KEGG, 54Reactome, 52QIAGEN
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Compounds for genes affiliated with Back Pain

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Back Pain according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8GCH1
2procollagen4510.8ALPP
3alphaxalone4510.6ALPP, CRH
4tolcapone45 1111.6COMT, CYP2C9
5meclofenamate4510.6CRH, CALCA
6ipriflavone4510.6CALCA, ALPP
7ether4510.6CRH, FAAH, CALCA
8micafungin45 1111.6COMT, CYP2C9
9etidronic acid45 50 1112.6ALPP, CALCA
10acth4510.5CRH, MC1R, THBS2
11deoxypyridinoline4510.5ALPP, MMP3, CALCA
12alendronate45 50 1112.5ALPP, MMP3, CALCA
13dopamine45 29 11 2413.4COMT, GCH1, CRH
14glibenclamide45 29 50 6013.4CYP2C9, CRH, CALCA
15dihydroneopterin triphosphate45 2411.4ALPP, GCH1
1624,25-dihydroxyvitamin d34510.4ALPP, CALCA
17diclofenac45 29 50 1113.4TTF2, MMP3, CYP2C9
18etidronate4510.4ALPP, CALCA
195-hydroxytryptamine4510.4CYP2C9, CRH, CALCA, COMT
20pyridinoline4510.4CALCA, MMP3, SPARC, ALPP
21hydroxyproline45 11 2412.4CALCA, SPARC, ALPP
22carbamazepine45 50 1112.4CRH, CYP2C9, ALPP
23ibuprofen45 29 50 11 2414.4FAAH, CYP2C9, MMP3
24serine4510.4ALPP, TTF2, MMP3, MC1R
25cocaine45 1111.4COMT, CRH, CYP2C9, ALPP
26folate4510.4COMT, GCH1, MC1R, ALPP
27nicotine45 50 29 1113.4COMT, CRH, CYP2C9, TTF2
28indomethacin45 60 29 1113.3CALCA, FAAH, CRH, CYP2C9, MMP3
29epinephrine45 11 2412.3COMT, GCH1, CALCA, CRH, CYP2C9
30heparin45 29 11 2413.3MMP3, TTF2, SPARC
31propranolol45 29 50 11 2414.3COMT, CALCA, CRH
32norepinephrine45 11 2412.3COMT, GCH1, CALCA, CRH, ALPP
33alizarin4510.2SPARC, ALPP
34calcium carbonate4510.2ALPP, CALCA
35creatinine4510.2CALCA, FABP4, CRH, MMP3, TTF2, ALPP
36acetaminophen45 2 50 11 2414.2MMP3, CYP2C9, FAAH
37ascorbic acid45 2411.2COMT, GCH1, MMP3, SPARC, ALPP
38chloramphenicol45 2 1112.2ALPP, MMP3, CYP2C9, CRH
39progesterone45 60 29 11 2414.2FAAH, CRH, CYP2C9, MMP3, TTF2, SPARC
40cyclosporin a45 29 6012.1CALCA, CYP2C9, MMP3, TTF2, SPARC, ALPP
41cysteine4510.1COMT, CRH, MMP3, TTF2, THBS2, SPARC
42testosterone45 60 11 2413.1COMT, CALCA, CRH, CYP2C9, SPARC, ALPP
43vegf4510.1CALCA, MMP3, TTF2, THBS2, SPARC, ALPP
44vitamin d4510.1ALPP, SPARC, TTF2, MMP3, MC1R, CRH
45alanine4510.1FAAH, CRH, MC1R, MMP3, TTF2, ALPP
46dexamethasone45 50 29 1113.1CRH, CYP2C9, MMP3, TTF2, SPARC, ALPP
47androstenedione45 2411.0COMT, CRH, CYP2C9
48sb 20358045 6010.9ALPP, SPARC, MMP3, CRH
49calcium45 50 11 2412.6GCH1, CALCA, FAAH, CILP, CYP2C9, MC1R
50retinoic acid45 2410.4ALPP, SPARC, MMP3, CYP2C9, FABP4, COMT

GO Terms for genes affiliated with Back Pain

Sources:
16Gene Ontology
See all sources

Cellular components related to Back Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type IXGO:00559410.2COL9A3, COL9A2
2proteinaceous extracellular matrixGO:00557810.0ASPN, SPARC, MMP3, CILP
3extracellular regionGO:0055769.3COL11A2, COL9A2, COL9A3, CALCA, CRH, MMP3

Biological processes related to Back Pain according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to painGO:04826510.2CRH, CALCA, GCH1, COMT
2negative regulation of blood pressureGO:04577610.1GCH1, CALCA, CRH
3collagen catabolic processGO:03057410.1COL11A2, COL9A2, COL9A3, MMP3
4extracellular matrix disassemblyGO:02261710.1MMP3, COL9A3, COL9A2, COL11A2
5response to lipopolysaccharideGO:03249610.1SPARC, GCH1, COMT
6positive regulation of cAMP biosynthetic processGO:0308199.9CALCA, CRH, MC1R
7extracellular matrix organizationGO:0301989.8SPARC, MMP3, COL9A3, COL9A2, COL11A2

Molecular functions related to Back Pain according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituent conferring tensile strengthGO:03002010.1COL9A3, COL9A2, COL11A2
2alkaline phosphatase activityGO:0040359.9ALPP, CILP
3calcium ion bindingGO:0055099.9MMP3, THBS2, SPARC, ASPN, GCH1

Products for genes affiliated with Back Pain

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Back Pain

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet