MCID: BCK003
MIFTS: 37

Background Diabetic Retinopathy

Categories: Eye diseases

Aliases & Classifications for Background Diabetic Retinopathy

MalaCards integrated aliases for Background Diabetic Retinopathy:

Name: Background Diabetic Retinopathy 12 14
Non Proliferative Diabetic Retinopathy 12
Non-Proliferative Diabetic Retinopathy 12
Nonproliferative Diabetic Retinopathy 69

Classifications:



External Ids:

Disease Ontology 12 DOID:13208
ICD9CM 34 362.01 362.03
UMLS 69 C0004606

Summaries for Background Diabetic Retinopathy

MalaCards based summary : Background Diabetic Retinopathy, also known as non proliferative diabetic retinopathy, is related to severe nonproliferative diabetic retinopathy and microvascular complications of diabetes 1. An important gene associated with Background Diabetic Retinopathy is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Malaria. The drugs Hydroxocobalamin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and endothelial, and related phenotype is digestive/alimentary.

Related Diseases for Background Diabetic Retinopathy

Diseases related to Background Diabetic Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 severe nonproliferative diabetic retinopathy 32.5 INS VEGFA
2 microvascular complications of diabetes 1 32.3 ANGPT2 VEGFA
3 microvascular complications of diabetes 5 29.8 ALB ANGPT2 INS VEGFA
4 juvenile nasopharyngeal angiofibroma 10.3 TLR9 VEGFA
5 critical limb ischemia 10.3 ANGPT2 VEGFA
6 pyogenic granuloma 10.3 ANGPT2 VEGFA
7 poems syndrome 10.2 ANGPT2 VEGFA
8 lipodermatosclerosis 10.2 ANGPT2 VEGFA
9 type 1 diabetes mellitus 7 10.2 HBA2 INS
10 type 1 diabetes mellitus 11 10.2 HBA2 INS
11 macular holes 10.2 ANGPT2 VEGFA
12 keratitis, hereditary 10.2 TLR9 VEGFA
13 female reproductive system disease 10.2 INS TLR9 VEGFA
14 acroosteolysis 10.2 ALB VEGFA
15 type 1 diabetes mellitus 5 10.2 HBA2 INS
16 hypertensive nephropathy 10.2 ALB VEGFA
17 burns 10.2 ALB INS
18 gastric lymphoma 10.2 ALB VEGFA
19 legionnaires' disease 10.2 ALB TLR9
20 autoimmune disease of urogenital tract 10.1 ALB TLR9
21 epileptic encephalopathy, childhood-onset 10.1 ANGPT2 VEGFA
22 fascioliasis 10.1 ALB INS
23 fetal erythroblastosis 10.1 ALB INS
24 microvascular complications of diabetes 3 10.1 ALB INS
25 hydrops, lactic acidosis, and sideroblastic anemia 10.1 ALB VEGFA
26 meningoencephalitis 10.1 ALB TLR9
27 prediabetes syndrome 10.1 ALB INS
28 limb ischemia 10.1 ANGPT2 VEGFA
29 keratoconjunctivitis sicca 10.1 ALB TLR9
30 hepatopulmonary syndrome 10.1 ALB VEGFA
31 placental insufficiency 10.1 ANGPT2 VEGFA
32 common cold 10.1 ALB TLR9
33 intermittent claudication 10.1 ALB VEGFA
34 hypoglycemic coma 10.0 HBA2 INS VEGFA
35 leukocyte disease 10.0 ALB TLR9
36 rubeosis iridis 10.0 HBA2 INS VEGFA
37 gastrointestinal system cancer 10.0 ALB TLR9 VEGFA
38 myeloma, multiple 10.0 ALB TLR9 VEGFA
39 urinary system disease 10.0 ALB INS TLR9
40 gastrointestinal system disease 10.0 ALB INS TLR9
41 ovarian hyperstimulation syndrome 9.9 ALB VEGFA
42 filariasis 9.9 ALB TLR9
43 autonomic nervous system disease 9.8 ALB HBA2 INS
44 retinitis 9.8
45 endotheliitis 9.8
46 arteries, anomalies of 9.7 ALB INS TLR9 VEGFA
47 nervous system disease 9.7 ALB INS TLR9 VEGFA
48 severe pre-eclampsia 9.7 ALB VEGFA
49 glucose metabolism disease 9.6 ALB HBA2 INS TLR9
50 acquired metabolic disease 9.6 ALB HBA2 INS TLR9

Graphical network of the top 20 diseases related to Background Diabetic Retinopathy:



Diseases related to Background Diabetic Retinopathy

Symptoms & Phenotypes for Background Diabetic Retinopathy

MGI Mouse Phenotypes related to Background Diabetic Retinopathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.02 ALB ANGPT2 INS TLR9 VEGFA

Drugs & Therapeutics for Background Diabetic Retinopathy

Drugs for Background Diabetic Retinopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
2
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
3
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
4
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
6
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
7
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
8
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
9
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
10
Glucosamine Approved, Investigational, Nutraceutical Phase 4 3416-24-8 439213
11 Hematinics Phase 4
12 Micronutrients Phase 4,Phase 2,Phase 1
13 Trace Elements Phase 4,Phase 2,Phase 1
14 Vitamin B 12 Phase 4
15 Vitamin B 6 Phase 4
16 Vitamin B Complex Phase 4,Phase 1,Phase 2
17 Vitamins Phase 4,Phase 2,Phase 1
18 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
19 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1
20 Hypoglycemic Agents Phase 4
21 insulin Phase 4
22 Insulin, Globin Zinc Phase 4
23 Anticoagulants Phase 4
24 Antimetabolites Phase 4
25 Fibrinolytic Agents Phase 4,Phase 2
26 Glucuronyl glucosamine glycan sulfate Phase 4
27 Hypolipidemic Agents Phase 4
28 Lipid Regulating Agents Phase 4
29
Cobalamin Nutraceutical Phase 4 13408-78-1 6438156
30 Folate Nutraceutical Phase 4,Phase 1,Phase 2
31 Vitamin B12 Nutraceutical Phase 4
32 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
33
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
34
Nepafenac Approved, Investigational Phase 3 78281-72-8 151075
35
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
36
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
37
Octreotide Approved, Investigational Phase 3 83150-76-9 6400441 383414
38
Ruboxistaurin Investigational Phase 3 169939-94-0, 202260-21-7 153999
39 Analgesics Phase 3
40 Analgesics, Non-Narcotic Phase 3
41 Antiemetics Phase 3,Phase 2
42 Anti-Inflammatory Agents Phase 3,Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 3
44 Antineoplastic Agents, Hormonal Phase 3,Phase 2
45 Antirheumatic Agents Phase 3
46 Autonomic Agents Phase 3,Phase 2
47 Gastrointestinal Agents Phase 3,Phase 2
48 glucocorticoids Phase 3,Phase 2
49 Hormone Antagonists Phase 3,Phase 2
50 Hormones Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 56)

# Name Status NCT ID Phase Drugs
1 Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy Unknown status NCT01921192 Phase 4 Folic Acid, vit B6 and B12;Placebo
2 Changes in Electroretinogram and Contrast Sensitivity After PASCAL Treatment Unknown status NCT00563043 Phase 4
3 Changes in Macular Thickness After Patterns Scan Laser Unknown status NCT00563628 Phase 4
4 Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
5 Avastin for Post-Photocoagulation Macular Edema Completed NCT00801866 Phase 4 Bevacizumab
6 CPAP Effect on the Progression of Diabetic Retinopathy in Patients With Sleep Apnea Recruiting NCT02874313 Phase 4 Pharmacological treatment
7 Comparison of Retinal Oxygenation and Retinal Vessel Diameters in Healthy Subjects and Patients With Diabetic Retinopathy or Retinal Vein Occlusion Between DVA and Oxymap Recruiting NCT02521116 Phase 4
8 Effects of Ranibizumab to Delay or Regression Non-proliferative Diabetic Retinopathy(NPDR) With DME Assessed by Microaneurysm Changes: A Pilot Study Not yet recruiting NCT02834663 Phase 4 Lucentis
9 A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects Unknown status NCT00908778 Phase 3 Vitreosolve;Vitreosolve
10 Nepafenac Once Daily for Macular Edema - Study 2 Completed NCT01872611 Phase 3 Nepafenac Ophthalmic Suspension, 0.3%;Prednisolone acetate
11 Nepafenac Once Daily for Macular Edema - Study 1 Completed NCT01853072 Phase 3 Nepafenac Ophthalmic Suspension, 0.3%;Prednisolone acetate
12 Intravitreal Bevacizumab for Diabetic Retinopathy Completed NCT00600262 Phase 2, Phase 3 intravitreal bevacizumab
13 Reduction in the Occurrence of Center-Involved Diabetic Macular Edema Completed NCT00090519 Phase 3 ruboxistaurin;placebo
14 Laser-Ranibizumab-Triamcinolone for Diabetic Macular Edema Completed NCT00444600 Phase 3 Triamcinolone Acetonide + laser;Ranibizumab + laser;Sham injection + laser;Ranibizumab + deferred laser
15 Anti-VEGF Treatment for Prevention of PDR/DME Recruiting NCT02634333 Phase 3 Prompt aflibercept;Deferred aflibercept
16 PROMINENT-Eye Ancillary Study (Protocol AD) Recruiting NCT03345901 Phase 3 Pemafibrate;Placebo
17 Treatment for CI-DME in Eyes With Very Good VA Study Recruiting NCT01909791 Phase 3 Prompt aflibercept;Deferred aflibercept
18 Study of the Efficacy and Safety of Intravitreal (IVT) Aflibercept for the Improvement of Moderately Severe to Severe Nonproliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT02718326 Phase 3 Intravitreal aflibercept injection [IAI];Sham
19 Phase III Study of Compound Danshen Dripping Pills to Treat Diabetic Retinopathy Active, not recruiting NCT02388984 Phase 3 Compound danshen dripping pills;Placebo
20 Extension Study of Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248131 Phase 3 Octreotide acetate in microspheres
21 Extension Study of the Long-term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy Terminated NCT00248157 Phase 3 Octreotide acetate in microspheres
22 A Safety and Efficacy Study of Vitreosolve® for Non-Proliferative Diabetic Retinopathy Subjects Terminated NCT00664183 Phase 2, Phase 3 Vitreosolve
23 Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy Completed NCT02062034 Phase 2 Ubiquinone;Combined antioxidant therapy;Placebo
24 A Clinical Trial Designed to Evaluate the Safety and Efficacy Study of Luminate® in Inducing PVD (Posterior Vitreous Detachment) in Non-Proliferative Diabetic Retinopathy Completed NCT02435862 Phase 2 1.0mg Luminate®;2.0mg Luminate®;3.0mg Luminate®
25 Evaluation of Effect of Doxycycline Verses Placebo on Retinal Function and Diabetic Retinopathy Completed NCT00917553 Phase 2 doxycycline monohydrate;Placebo
26 Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment Completed NCT00198471 Phase 2 Vitrase
27 Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema Completed NCT01571232 Phase 2 dexamethasone intravitreal implant;intravitreal bevacizumab
28 A Study That Tests BI 1467335 in Patients With Diabetic Eye Disease (Diabetic Retinopathy). It Looks at the Way BI 1467335 is Taken up, the Effects it Has, and How Well it is Tolerated. Recruiting NCT03238963 Phase 2 BI 1467335;Placebo
29 The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy Recruiting NCT03006081 Phase 2 Intravitreal Aflibercept injection
30 The TIME-2b Study: A Study of AKB-9778, a Novel Tie 2 Activator, in Patients With Non-Proliferative Diabetic Retinopathy (NPDR) Active, not recruiting NCT03197870 Phase 2 AKB-9778;Placebo
31 A Study to Evaluate the Efficacy and Safety of Ocriplasmin in Inducing Total PVD in Subjects With NPDR Active, not recruiting NCT02681809 Phase 2 ocriplasmin 0.0625mg;ocriplasmin 0.125mg;Sham injection
32 Efficacy & Safety Trial of Intravitreal Injections Combined With PRP for CSME Secondary to Diabetes Mellitus (DAVE) Active, not recruiting NCT01552408 Phase 1, Phase 2 0.3 mg ranibizumab
33 A Study of Keluo Xin Capsule Compare to Placebo in Terms of Efficacy and Safety in Patients With Diabetic Retinopathy Not yet recruiting NCT03258242 Phase 2 Keluo Xin capsule;Placebo oral capsule
34 The Use of Alpha Lipoic Acid for the Treatment and Prevention of Diabetic Retinopathy Suspended NCT01880372 Phase 1, Phase 2
35 Panretinal Photo-stimulation in Proliferative Diabetic Retinopathy Unknown status NCT02309502
36 Blood-retinal Barrier Imaging and Neuropsychiatric Sequela in Type 2 Diabetes Mellitus Unknown status NCT01107132
37 Diabetic Macular Edema and Diabetic Retinopathy Screening (TeleMed) With Automated Retinal Photography Unknown status NCT01790945
38 OCT Biomarkers for Diabetic Retinopathy Unknown status NCT02330042
39 Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics Unknown status NCT00698698
40 Phenotypes of Nonproliferative Diabetic Retinopathy in DM 2 Patients Identified by OCT, CFP, RLA and mfERG (DIAMARKER) Completed NCT01440660
41 Validation of a Predictive Model to Estimate the Risk of Conversion to Clinically Significant Macular Edema and/or Vision Loss in Mild Nonproliferative Diabetic Retinopathy in Diabetes Type 2 Completed NCT00763802
42 Identifying Progression of Retinal Disease in Eyes With NPDR in Diabetes Type 2 Using Non-invasive Procedures Completed NCT01145599
43 Computer Detection of Diabetic Retinopathy Compared to Clinical Examination Completed NCT01625598
44 Diabetes Visual Function Supplement Study Completed NCT01646047
45 Observational Study of DME Following Scatter Laser Photocoagulation Completed NCT00687154
46 Neurovascular Coupling in Patients With Early Stage Diabetes Retinopathy Completed NCT00712842
47 Evaluation of Blood-retinal Barrier Functional Alterations by Optical Coherence Tomography Completed NCT01220804
48 Safety and Effectiveness Study of 532nm Laser Subthreshold Panretinal Photocoagulation for Severe NPDR Recruiting NCT01759121
49 Dyslipidemia and Diabetic Retinopathy Recruiting NCT03403283
50 Early Laser Treatment for Diabetic Eye Disease in China : A Pilot Randomized Trial Recruiting NCT02956759

Search NIH Clinical Center for Background Diabetic Retinopathy

Genetic Tests for Background Diabetic Retinopathy

Anatomical Context for Background Diabetic Retinopathy

MalaCards organs/tissues related to Background Diabetic Retinopathy:

38
Eye, Liver, Endothelial, Testes

Publications for Background Diabetic Retinopathy

Articles related to Background Diabetic Retinopathy:

(show all 11)
# Title Authors Year
1
The influence of background diabetic retinopathy in the second eye on rates of progression of diabetic retinopathy between 2005 and 2010. ( 23551550 )
2013
2
From minimal background diabetic retinopathy to profuse sight threatening vitreoretinal haemorrhage: management issues in a case of pregestational diabetes and pregnancy. ( 12873299 )
2003
3
Massive subretinal bleed in a patient with background diabetic retinopathy and on treatment with warfarin. ( 12855977 )
2003
4
Background diabetic retinopathy in Harare, Zimbabwe. ( 10448253 )
1999
5
Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat. ( 9519746 )
1998
6
Contrast sensitivity changes in background diabetic retinopathy. ( 2013027 )
1991
7
Does increased platelet aggregation have a prognostic value in the deterioration of background diabetic retinopathy? The Damad Study Group. ( 2270529 )
1990
8
Treatment of background diabetic retinopathy. ( 3508804 )
1987
9
Pattern electroretinograms become abnormal when background diabetic retinopathy deteriorates to a preproliferative stage: possible use as a screening test. ( 3964635 )
1986
10
Blood pressure and the progression of mild background diabetic retinopathy. ( 4077241 )
1985
11
Effect of pure O2-breathing on retinal blood flow in normals and in patients with background diabetic retinopathy. ( 6690224 )
1984

Variations for Background Diabetic Retinopathy

Expression for Background Diabetic Retinopathy

Search GEO for disease gene expression data for Background Diabetic Retinopathy.

Pathways for Background Diabetic Retinopathy

GO Terms for Background Diabetic Retinopathy

Cellular components related to Background Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.43 ALB INS ITIH2
2 extracellular space GO:0005615 9.43 ALB ANGPT2 HBA2 INS TLR9 VEGFA
3 blood microparticle GO:0072562 9.33 ALB HBA2 ITIH2
4 extracellular region GO:0005576 9.17 ALB ANGPT2 HBA2 INS ITIH2 TLR9

Biological processes related to Background Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 ALB INS ITIH2
2 positive regulation of protein autophosphorylation GO:0031954 8.62 INS VEGFA

Molecular functions related to Background Diabetic Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.62 ALB HBA2

Sources for Background Diabetic Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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