MCID: BCT007
MIFTS: 49

Bacterial Meningitis malady

Rare diseases, Neuronal diseases, Infectious diseases, Respiratory diseases categories
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Summaries for Bacterial Meningitis

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4CDC, 33MalaCards
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CDC:4 Bacterial meningitis is usually severe. While most people with meningitis recover, it can cause serious complications, such as brain damage, hearing loss, or learning disabilities.

MalaCards: Bacterial Meningitis, also known as meningitis, bacterial, is related to meningitis and pneumonia. An important gene associated with Bacterial Meningitis is PGLYRP2 (peptidoglycan recognition protein 2), and among its related pathways are Complement Pathway and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds anaphylatoxin and leukotriene b4 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are skeleton and immune system.

Aliases & Classifications for Bacterial Meningitis

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8Disease Ontology, 43NIH Rare Diseases, 62UMLS, 45Novoseek, 58SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

bacterial meningitis 8 43
meningitis, bacterial 43 62
meningitis bacterial 45


External Ids:

Disease Ontology8 DOID:9470
ICD9CM27 320, 320.9
MeSH35 D016920
ICD1025 G00

Related Diseases for Bacterial Meningitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to bacterial meningitis

Symptoms for Bacterial Meningitis

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Drugs & Therapeutics for Bacterial Meningitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bacterial Meningitis

Search NIH Clinical Center for Bacterial Meningitis

Genetic Tests for Bacterial Meningitis

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Anatomical Context for Bacterial Meningitis

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33MalaCards
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MalaCards organs/tissues related to Bacterial Meningitis:

33
Brain, Testes, Pituitary, Myeloid, Liver, Skin, Prostate, Spinal cord, Tonsil, T cells, Pineal, Bone

Animal Models for Bacterial Meningitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bacterial Meningitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CFP, PGLYRP2, ADA, C3AR1
2MP:00053878.4C3AR1, ADA, PGLYRP2, AQP4, CFP
3MP:00107688.4C3AR1, ADA, PGLYRP2, AQP4, CFP
4MP:00053768.1CFP, AQP4, PGLYRP2, ADA, C3AR1

Publications for Bacterial Meningitis

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52PubMed
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Articles related to Bacterial Meningitis:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Association of treatment for bacterial meningitis with the development of sequelae. (23537920)
2013
2
Lumbar drainage for the treatment of severe bacterial meningitis. (23739926)
2013
3
The bacterial meningitis score to distinguish bacterial from aseptic meningitis in children from Sao Paulo, Brazil. (24008742)
2013
4
Diagnostic value of latex agglutination test in diagnosis of acute bacterial meningitis. (24339598)
2013
5
Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis. (23053059)
2013
6
Osmotic therapies added to antibiotics for acute bacterial meningitis. (23543568)
2013
7
Nosocomial bacterial meningitis - prevention rather than cure! (23901732)
2013
8
Resveratrol suppresses calcium-mediated microglial activation and rescues hippocampal neurons of adult rats following acute bacterial meningitis. (23273676)
2013
9
Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis. (23383133)
2013
10
Bacterial meningitis in adults after splenectomy and hyposplenic states. (23628588)
2013
11
Independent validation of an existing model enables prediction of hearing loss after childhood bacterial meningitis. (23536814)
2013
12
Computational approaches to identify common subunit vaccine candidates against bacterial meningitis. (23740398)
2013
13
Bacterial meningitis in children in Iceland, 1975-2010: a nationwide epidemiological study. (23968225)
2013
14
Neutrophilic bacterial meningitis: pathology and etiologic diagnosis of fatal cases. (23558577)
2013
15
Bacterial Meningitis in Brazil: Baseline Epidemiologic Assessment of the Decade Prior to the Introduction of Pneumococcal and Meningococcal Vaccines. (23823579)
2013
16
Effect of vaccines on bacterial meningitis worldwide. (23141619)
2012
17
Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis. (22075766)
2012
18
Prognostic accuracy of five simple scales in childhood bacterial meningitis. (22292706)
2012
19
Clinical features and course of bacterial meningitis in children. (23272517)
2012
20
The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis. (22713513)
2012
21
Risk factors for neurological complications and sequelae in childhood acute bacterial meningitis. (22543733)
2012
22
Validation of diagnostic algorithm to differentiate between tuberculous meningitis and acute bacterial meningitis. (22244850)
2012
23
Cerebral infarction in adults with bacterial meningitis. (21989842)
2012
24
Serum procalcitonin in viral and bacterial meningitis. (21572603)
2011
25
Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial. (21334262)
2011
26
Predictors of bacterial meningitis in resource-limited contexts: an Angolan case. (21991337)
2011
27
Clinical characteristics and therapeutic outcomes of nosocomial super-infection in adult bacterial meningitis. (21592372)
2011
28
Bacterial meningitis in childhood. (22125045)
2011
29
Incorporation of real-time PCR into routine public health surveillance of culture negative bacterial meningitis in SALo Paulo, Brazil. (21731621)
2011
30
Regulation of activin A synthesis in microglial cells: pathophysiological implications for bacterial meningitis. (19681171)
2010
31
Unexpected non-seasonal increase of bacterial meningitis cases in Georgia in 2009. (20834075)
2010
32
Influence of malnutrition on the course of childhood bacterial meningitis. (19934786)
2010
33
Antibiotic treatment for bacterial meningitis caused by Listeria monocytogenes in a patient with multiple myeloma. (20112040)
2010
34
Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (20625175)
2010
35
Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. (20417414)
2010
36
Prospective cohort study of disabling sequelae and quality of life in children with bacterial meningitis in urban Senegal. (20517172)
2010
37
Bilateral endophthalmitis as the initial presentation of bacterial meningitis. (20046699)
2009
38
Mononuclear cell subpopulations in CSF and blood of children with bacterial meningitis. (19046603)
2009
39
Recurrent bacterial meningitis after cochlear implantation in a patient with a newly described labyrinthine malformation. (19027967)
2009
40
Bacterial meningitis score is valid in other populations of children. (18571557)
2008
41
Should adults with suspected bacterial meningitis receive adjunctive dexamethasone? (18334977)
2008
42
Battling bacterial meningitis in developing countries. (18565445)
2008
43
Expression of death-related proteins in dentate granule cells in human bacterial meningitis. (11556687)
2001
44
Acute obstructive hydrocephalus complicating bacterial meningitis. Use of dexamethasone remains contentious. (10068234)
1999
45
Bacterial meningitis and meningococcal infection. (9529632)
1998
46
Cerebrospinal fluid adenosine deaminase activity and C-reactive protein in tuberculous and partially treated bacterial meningitis. (8635832)
1995
47
Loss of erythrocyte complement receptors (CR1; CD35) in patients with acute episodes of septicaemia or bacterial meningitis. (1641596)
1992
48
Deficiency of IgG subclasses and IgA, and elevation of IgE in children with a past history of bacterial meningitis. (1867083)
1991
49
Cerebrospinal fluid prostaglandins, interleukin 1 beta, and tumor necrosis factor in bacterial meningitis. Clinical and laboratory correlations in placebo-treated and dexamethasone-treated patients. (2116086)
1990
50
Evaluation of aztreonam in experimental bacterial meningitis and cerebritis. (6362552)
1983

Variations for Bacterial Meningitis

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Expression for genes affiliated with Bacterial Meningitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for genes affiliated with Bacterial Meningitis

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50PathCards, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 54R&D Systems
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Compounds for genes affiliated with Bacterial Meningitis

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45Novoseek, 61Tocris Bioscience, 24HMDB, 29IUPHAR, 51PharmGKB, 11DrugBank
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Compounds related to Bacterial Meningitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1anaphylatoxin459.8CFP, C3AR1
2leukotriene b445 61 2411.2FPR2, CXCL5
3Water249.2ADA, PGLYRP2, AQP4
4superoxide45 249.9FPR2, CXCL5, CFP
5histamine45 29 2410.6AQP4, ADA, C3AR1, FPR2
6fmlp458.6FPR2, C3AR1, CXCL5, ADA
7oligonucleotide458.6AQP4, CXCL5, FPR2
8dexamethasone45 51 29 1111.5FPR2, CXCL5, ADA, AQP4

GO Terms for genes affiliated with Bacterial Meningitis

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16Gene Ontology
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Cellular components related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4LYZ, CXCL5, PGLYRP2, CFP
2extracellular spaceGO:0056157.9LYZ, CXCL5, ADA, CFP

Biological processes related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to bacteriumGO:0427429.2LYZ, CFP
2chemotaxisGO:0069358.9FPR2, C3AR1, CXCL5
3inflammatory responseGO:0069548.4FPR2, C3AR1, LYZ

Molecular functions related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-formyl peptide receptor activityGO:0049829.5FPR2, C3AR1

Products for genes affiliated with Bacterial Meningitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacterial Meningitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet