MCID: BCT007
MIFTS: 52

Bacterial Meningitis malady

Neuronal category

Summaries for Bacterial Meningitis

Sources:
3CDC, 33MalaCards
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CDC:3 Bacterial meningitis is usually severe. While most people with meningitis recover, it can cause serious complications, such as brain damage, hearing loss, or learning disabilities.

MalaCards: Bacterial Meningitis, also known as meningitis, bacterial, is related to viral meningitis and aseptic meningitis. An important gene associated with Bacterial Meningitis is CFP (complement factor properdin), and among its related pathways are Passive Transport by Aquaporins and Spinal Cord Injury. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are hematopoietic system and skeleton.

Aliases & Classifications for Bacterial Meningitis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 61UMLS, 45Novoseek, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

bacterial meningitis 8 43
meningitis, bacterial 43 61
meningitis bacterial 45


External Ids:

Disease Ontology8 DOID:9470
ICD9CM27 320, 320.9
MeSH35 D016920
ICD1025 G00

Related Diseases for Bacterial Meningitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the viral meningitis family:

bacterial meningitis chronic meningitis
meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1viral meningitis30.8CRP, ADA
2aseptic meningitis30.7GUSB, ADA
3meningococcal meningitis30.7CFP, MBL2
4sepsis30.3TLR9, MBL2, CRP, CXCL5, IL17A, FCGR2A
5tuberculosis30.3TLR9, MBL2, GUSB, CRP, IL17A, ADA
6arthritis30.2GUSB, CRP, CXCL5, IL17A, MMP8, FCGR2A
7uveitis30.0IL17A
8tonsillitis30.0CRP
9systemic lupus erythematosus30.0CRP, FCGR2A
10thrombocytopenia30.0FCGR2A, GUSB
11bacteremia30.0MBL2, GUSB, CRP
12neonatal meningitis10.6
13tuberculous meningitis10.5
14mondini dysplasia10.4
15pneumococcal meningitis10.4
16obstructive hydrocephalus10.4
17head injury10.3
18pituitary apoplexy10.2
19meningocele10.2
20encephalocele10.2
21epidural abscess10.2
22subdural empyema10.2
23cerebral arteritis10.2
24cerebritis10.2
25cortical blindness10.2
26cauda equina syndrome10.2
27listeria meningitis10.2
28meningococcal infection10.2
29brain injury10.2
30sinusitis10.2
31blindness10.2
32anaerobic meningitis10.0
33decubitus ulcer10.0
34discitis10.0
35pyuria10.0
36relapsing polychondritis10.0
37quadriplegia10.0
38common variable immunodeficiency10.0
39arachnoiditis10.0
40thrombocytosis10.0
41panhypopituitarism10.0
42crouzon syndrome10.0
43viral encephalitis10.0
44reactive arthritis10.0
45measles10.0
46chickenpox10.0
47streptococcal meningitis10.0
48scrub typhus10.0
49cerebral malaria10.0
50rocky mountain spotted fever10.0

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to bacterial meningitis

Clinical Features for Bacterial Meningitis

Drugs & Therapeutics for Bacterial Meningitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bacterial Meningitis

Drug clinical trials:

Search ClinicalTrials for Bacterial Meningitis

Search NIH Clinical Center for Bacterial Meningitis

Search CenterWatch for Bacterial Meningitis

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bacterial Meningitis:

33
Skin, Liver, Spinal cord, Brain, Kidney, Prostate, Tonsil, Myeloid, T cells, B cells, Pineal, Pituitary

Animal Models for Bacterial Meningitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Bacterial Meningitis

Sources:
51PubMed
See all sources

Articles related to Bacterial Meningitis:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Population-based Surveillance for Bacterial Meningitis in China, September 2006-December 2009. (24377388)
2014
2
Lumbar drainage for the treatment of severe bacterial meningitis. (23739926)
2013
3
Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis. (23383133)
2013
4
Oxidative stress in children with bacterial meningitis. (23436234)
2013
5
Distributed, limbic gray matter atrophy in patients after bacterial meningitis. (23194831)
2013
6
Corticosteroids for acute bacterial meningitis. (23733364)
2013
7
Risk factors for death and severe sequelae in Malawian children with bacterial meningitis, 1997-2010. (22914560)
2013
8
Bacterial meningitis in children <2 years of age in a tertiary care hospital in South India: an assessment of clinical and laboratory features. (23773591)
2013
9
Bacterial meningitis: tailoring management to patient characteristics. (23355997)
2013
10
Sudden Onset Permanent Deafness as an Early Complication of Bacterial Meningitis. (23783768)
2013
11
Should corticosteroids be used in bacterial meningitis in children? (22789668)
2013
12
Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis. (22075766)
2012
13
Prognostic accuracy of five simple scales in childhood bacterial meningitis. (22292706)
2012
14
Validation of diagnostic algorithm to differentiate between tuberculous meningitis and acute bacterial meningitis. (22244850)
2012
15
Prognostic accuracy of five simple scales in childhood bacterial meningitis. (22830535)
2012
16
Recurrent bacterial meningitis by three different pathogens in an isolated asplenic child. (22147274)
2012
17
Acute bacterial and viral meningitis. (23221840)
2012
18
Cerebrospinal fluid enrichment broth cultures rarely contribute to the diagnosis of bacterial meningitis. (22315003)
2012
19
Clinical characteristics and therapeutic outcomes of nosocomial super-infection in adult bacterial meningitis. (21592372)
2011
20
Incorporation of real-time PCR into routine public health surveillance of culture negative bacterial meningitis in SALo Paulo, Brazil. (21731621)
2011
21
Immediate outcomes of bacterial meningitis in childhood may benefit from slow initial I^-lactam infusion and oral paracetamol. (22004030)
2011
22
The use of S100B and Tau protein concentrations in the cerebrospinal fluid for the differential diagnosis of bacterial meningitis: a retrospective analysis. (21865761)
2011
23
Culture proven bacterial meningitis in children: agents, clinical profile and outcome. (22610807)
2011
24
Etiology of acute bacterial meningitis in hospitalized children in western Uttar Pradesh. (22253163)
2011
25
An audit of acute bacterial meningitis in a large teaching hospital 2005-10. (21840886)
2011
26
Diagnostic accuracy of a 16S ribosomal DNA gene-based molecular technique (RT-PCR, microarray, and sequencing) for bacterial meningitis, early-onset neonatal sepsis, and spontaneous bacterial peritonitis. (21251558)
2011
27
Cerebral infarction in bacterial meningitis: predictive factors and outcome. (19946782)
2010
28
The evaluation and management of bacterial meningitis: current practice and emerging developments. (20445424)
2010
29
Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. (20610819)
2010
30
Signs, symptoms and management of bacterial meningitis. (21140892)
2010
31
Neonatal bacterial meningitis. (21089719)
2010
32
Comparison of 16S rDNA-PCR Amplification and Culture of Cerebrospinal Fluid for Diagnosis of Bacterial Meningitis. (23056748)
2010
33
New understandings on the pathophysiology of bacterial meningitis. (20216309)
2010
34
NICE on bacterial meningitis. Vancomycin may not be necessary. (20801988)
2010
35
Etiologies of bacterial meningitis in Bangladesh: results from a hospital-based study. (19706918)
2009
36
Two cases of bacterial meningitis accompanied by thalidomide therapy in patients with multiple myeloma: is thalidomide associated with bacterial meningitis? (18621563)
2009
37
Past as prologue: delayed stroke as a parainfectious process of bacterial meningitis? (19890067)
2009
38
Identifying low-risk patients for bacterial meningitis in adult patients with acute meningitis. (19336955)
2009
39
Bacterial meningitis score is valid in other populations of children. (18571557)
2008
40
Giant anterior sacral meningocele presenting as bacterial meningitis in a previously healthy adult. (19292186)
2008
41
Immunohistochemical analysis of MMP-9, MMP-2 and TIMP-1, TIMP-2 expression in the central nervous system following infection with viral and bacterial meningitis. (19141395)
2008
42
Bacterial meningitis and sigmoid diverticulitis caused by Listeria monocytogenes. (18751639)
2008
43
Bacterial meningitis: an urgent need for further progress to reduce mortality and morbidity. (18505990)
2008
44
A decision rule for predicting bacterial meningitis in children with cerebrospinal fluid pleocytosis when gram stain is negative or unavailable. (18439199)
2008
45
Response to 'Benefits of glucocorticoids in the treatment of bacterial meningitis in children: End of the controversy?'. (19030241)
2006
46
Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis. (10641604)
2000
47
Eleven-month-old with recurrent bacterial and aseptic meningitis. (10694015)
2000
48
Pretreatment with granulocyte colony-stimulating factor attenuates the inflammatory response but not the bacterial load in cerebrospinal fluid during experimental pneumococcal meningitis in rabbits. (10377123)
1999
49
Adenosine deaminase levels in cerebrospinal fluid in tuberculosis and bacterial meningitis. (7579324)
1995
50
The relative role of bacterial cell wall and capsule in the induction of inflammation in pneumococcal meningitis. (3973407)
1985

Genetic Variations for Bacterial Meningitis

Expression for genes affiliated with Bacterial Meningitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for genes affiliated with Bacterial Meningitis

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Bacterial Meningitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3AQP4, AQP1
210.3FCGR2A, AQP1, AQP4
3
Immune response Lectin induced complement pathway
Hide members
10.2MBL2, CRP, CFP, C3AR1
410.2MBL2, FPR2, FCGR2A, C3AR1

Compounds for genes affiliated with Bacterial Meningitis

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1endotoxin4510.8CXCL5
2pge24510.8FPR2
3mannitol45 1111.8CRP, AQP4
4forskolin45 50 1112.7NTF3, CKB
5mannan4510.7IL17A, MBL2, CFP
6Alpha-D-Mannose1110.6LYZ, GUSB, MBL2
7etanercept45 50 1112.6CRP, IL17A, FCGR2A
8vitamin b124510.6GUSB, CRP, ADA
92 chloroadenosine4510.6ADA, NTF3
10peptidoglycan45 2911.6PGLYRP2, TLR9, MBL2
11neopterin4510.6CRP, ADA, MBL2
12lactulose4510.6CRP, GUSB
13mannose4510.6IL17A, MBL2, CFP, FCGR2A
14rantes4510.6IL17A, CXCL5, MBL2
15aspirin45 50 29 2413.6GUSB, CRP, FPR2, ADA
16oxygen45 2411.6FPR2, MBL2, MMP8
17hydroxychloroquine45 1111.5CRP, TLR9
18amide4510.5PGLYRP2, MBL2, MMP8
19fmlp4510.5FCGR2A, ADA, C3AR1, CXCL5, GUSB, FPR2
20aspartate4510.5MBL2, NTF3, GUSB, CKB, ADA
21lactate4510.5GUSB, ADA, MMP8, CKB, CRP
22leukotriene b445 60 2412.5CXCL5, FPR2, GUSB
23vas-a4510.5AQP4, AQP1
24histamine45 29 2412.5C3AR1, NTF3, GUSB, FPR2, FCGR2A, ADA
25dexamethasone45 50 29 1113.4AQP4, MBL2, AQP1, ADA, FPR2, IL17A
26sodium45 2411.4CKB, AQP4, AQP1, NTF3, MBL2
27superoxide45 2411.4MBL2, CFP, MMP8, FPR2, CXCL5, NTF3
28acetylcholine45 50 29 11 2414.4GUSB, NTF3, ADA
29cysteine4510.4MBL2, NTF3, MMP8, CFP, ADA, AQP1
30creatinine4510.4CKB, AQP1, ADA, IL17A, CRP, MBL2
31glucose4510.4MMP8, AQP1, CKB, NTF3
32nitric oxide45 11 2412.4MBL2, NTF3, CXCL5, IL17A, MMP8, AQP1
33oligonucleotide4510.4FPR2, AQP4, TLR9, CXCL5, IL17A, MMP8
34progesterone45 60 29 11 2414.3MBL2, CKB, MMP8, NTF3, CXCL5
35vegf4510.3ADA, MMP8, NTF3, IL17A, CXCL5, CRP
36serine4510.3FCGR2A, MMP8, C3AR1
37lipid4510.3MBL2, CRP, IL17A, FPR2, MMP8, FCGR2A
38tyrosine4510.3MBL2, C3AR1, CXCL5, IL17A, FCGR2A, TLR9
39p0024510.3MMP8, CRP, IL17A
40ly2940024510.2NTF3, FCGR2A, CRP, IL17A
41calcium45 50 11 2413.1CXCL5, MMP8, FPR2, C3AR1, AQP1, NTF3
42tuberculin4510.1MBL2, ADA
43steroid4510.0MBL2, CKB, NTF3, IL17A, AQP1

GO Terms for genes affiliated with Bacterial Meningitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.0CRP, CXCL5, IL17A, MMP8, CFP, ADA
2extracellular regionGO:0055769.5LYZ, TLR9, MBL2, CRP, NTF3, GBP1

Biological processes related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.4AQP1, AQP4
2defense response to bacteriumGO:04274210.4TLR9, MBL2, CFP, LYZ
3defense response to Gram-positive bacteriumGO:05083010.4MBL2, CRP, PGLYRP2
4carbon dioxide transportGO:01567010.3AQP4, AQP1
5chemotaxisGO:00693510.3C3AR1, FPR2, CXCL5
6inflammatory responseGO:00695410.3LYZ, C3AR1, FPR2, IL17A, CRP, TLR9
7opsonizationGO:00822810.2CRP, MBL2
8innate immune responseGO:0450879.8TLR9, MBL2, PGLYRP2, CFP, FCGR2A

Molecular functions related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-formyl peptide receptor activityGO:00498210.4C3AR1, FPR2
2water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Bacterial Meningitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacterial Meningitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet