MCID: BCT007
MIFTS: 59

Bacterial Meningitis

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 72 49 3 14
Meningitis, Bacterial 49 41 69
Meningitis Bacterial 51

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD10 32 G00 G00.9
ICD9CM 34 320 320.9
MeSH 41 D016920
NCIt 46 C118297
UMLS 69 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Español: Meningitis bacteriana

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to cerebral palsy and streptococcal meningitis. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 72 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 419)
# Related Disease Score Top Affiliating Genes
1 cerebral palsy 31.6 IL1B IL6 TNF
2 streptococcal meningitis 31.2 CFP CRP TNF
3 aseptic meningitis 30.5 CXCL8 IL10 IL1B TNF
4 haemophilus influenzae 30.4 CXCL8 IL1B TLR2 TNF
5 tuberculous meningitis 30.2 CXCL8 MMP9 TLR2 TNF
6 viral meningitis 30.2 CRP CXCL8 IL6
7 mycobacterium tuberculosis 1 30.1 IL10 TLR2 TLR9 TNF
8 suppurative otitis media 30.0 CRP IL1B TLR2
9 diverticulitis 30.0 CRP MMP9 TNF
10 scrub typhus 29.9 CRP IL10 IL1B TLR2 TNF
11 brain injury 29.9 IL10 IL6 S100B
12 traumatic brain injury 29.8 IL10 IL6 S100B
13 hematopoietic stem cell transplantation 29.8 IL10 IL6 TNF
14 pyuria 29.7 ALB CRP CXCL8
15 acute cholangitis 29.7 CRP IL6
16 myeloma, multiple 29.5 ALB CXCL8 IL6 TLR9
17 common variable immunodeficiency 29.5 IL10 IL6 TLR9 TNF
18 tonsillitis 29.3 CXCL8 IL1B IL6 TLR9 TNF
19 prostatitis 29.3 CXCL8 IL10 IL1B IL6 TNF
20 osteomyelitis 29.2 CXCL8 IL10 IL1B IL6 TNF
21 cholangitis 29.2 ALB CRP IL6 TNF
22 reactive arthritis 29.2 CRP IL10 IL6 MMP8 TNF
23 meningitis 29.2 ALB CFP CRP CXCL8 IL10 IL1B
24 arthritis 29.1 CXCL8 IL10 IL1B IL6 MMP9 TNF
25 pneumonia 28.5 CRP CXCL8 IL10 IL1B IL6 PIK3C2A
26 systemic lupus erythematosus 28.4 ALB CRP IL10 IL1B IL6 TLR9
27 otitis media 28.4 ALB CXCL8 IL10 IL1B IL6 TLR2
28 multiple sclerosis 28.2 IL10 IL1B IL6 MMP9 PTGDS TLR9
29 peritonitis 28.1 ALB CRP CXCL8 IL10 IL1B IL6
30 endocarditis 28.0 ALB CRP CXCL8 IL10 IL6 PIK3C2A
31 malaria 27.8 ALB CRP CXCL8 IL10 IL1B IL6
32 haemophilus meningitis 11.5
33 meningococcal meningitis 10.9
34 punctate inner choroidopathy 10.6 IL10 TNF
35 pneumococcal meningitis 10.6
36 polyposis, gastric 10.6 IL1B TNF
37 tropical endomyocardial fibrosis 10.6 IL10 TNF
38 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
39 staphylococcal toxic shock syndrome 10.5 IL1B TNF
40 microscopic polyangiitis 10.5 IL10 TNF
41 prosthetic joint infection 10.5 IL1B TLR2
42 multifocal choroiditis 10.5 IL10 TNF
43 mycobacterium chelonae 10.5 CXCL8 TLR2
44 endomyocardial fibrosis 10.5 IL10 TNF
45 kashin-beck disease 10.5 IL1B TNF
46 chronic follicular conjunctivitis 10.5 IL1B MMP9
47 coccidiosis 10.5 IL10 TLR9 TNF
48 crohn's colitis 10.4 CXCL8 IL1B TNF
49 dental pulp disease 10.4 CXCL8 IL1B TNF
50 neurosyphilis 10.4 IL10 TLR2

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 IL6 ALB CFP MMP8 CRP MMP9
2 immune system MP:0005387 10.1 IL6 CFP MMP8 CRP MMP9 IL10
3 cardiovascular system MP:0005385 10.09 IL6 CFP CRP MMP9 IL10 PIK3C2A
4 digestive/alimentary MP:0005381 9.95 ALB IL6 MMP9 IL10 TNF TLR2
5 mortality/aging MP:0010768 9.9 IL1B PTGDS ALB IL6 CFP MMP9
6 integument MP:0010771 9.86 PTGDS IL6 MMP9 IL10 IL1B TNF
7 neoplasm MP:0002006 9.61 IL6 ALB MMP8 MMP9 IL10 IL1B
8 skeleton MP:0005390 9.23 IL1B PTGDS IL6 CFP MMP9 IL10

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
5
Azathioprine Approved Phase 4 446-86-6 2265
6
Ceftriaxone Approved Phase 4,Phase 3,Phase 1 73384-59-5 5479530 5361919
7
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 5742673 456256
8
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
9 Sodium Channel Blockers Phase 4
10 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
11 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2
12 Diuretics, Potassium Sparing Phase 4
13 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
14 Anticonvulsants Phase 4
15 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Immunoglobulins Phase 4,Phase 3,Phase 2
17 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
18 Antibodies Phase 4,Phase 3,Phase 2
19 penicillins Phase 4,Phase 3
20 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
21 Analgesics Phase 4,Phase 3,Phase 2
22 glucocorticoids Phase 4,Phase 2,Phase 3
23
protease inhibitors Phase 4,Phase 2,Phase 3
24 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
25 Gentamicins Phase 4,Phase 3
26 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 1
27 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
28 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1,Phase 2
30 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
31 Hormone Antagonists Phase 4,Phase 2,Phase 3
32 Hormones Phase 4,Phase 2,Phase 3
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
35 Antiemetics Phase 4,Phase 2,Phase 3
36 Immunosuppressive Agents Phase 4
37 Antimetabolites Phase 4
38 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
39 Antimetabolites, Antineoplastic Phase 4
40 Lactams Phase 4
41 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
42 Antipyretics Phase 4,Phase 3,Phase 2
43 BB 1101 Phase 4,Phase 2,Phase 3
44 beta-Lactams Phase 4
45 Autonomic Agents Phase 4,Phase 2,Phase 3
46 Antirheumatic Agents Phase 4,Phase 2
47 Neuromuscular Blocking Agents Phase 4
48
Rifampin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5381226 5458213
49
Glycerol Approved, Investigational Phase 3 56-81-5 753
50
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046

Interventional clinical trials:

(show top 50) (show all 133)

# Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
3 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
4 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
5 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
6 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
7 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
8 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
9 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
10 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
11 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
12 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Active, not recruiting NCT02864927 Phase 4
13 Ciprofloxacin for the Prevention of Meningococcal Meningitis 2018 Not yet recruiting NCT03431675 Phase 4 Ciprofloxacin
14 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4 Dexamethasone acetate
15 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
16 Amikacin Penetration Into the Cerebrospinal Fluid Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
17 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
18 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Completed NCT01547715 Phase 3
19 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
20 Safety and Immunogenicity Study of MenC-TT Vaccine (NeisVac-C) in Toddlers Previously Immunized With PCV7 (Prevenar®) Completed NCT00617760 Phase 3
21 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
22 DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants Completed NCT02274285 Phase 3
23 A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India Completed NCT01086969 Phase 3
24 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Toddlers Completed NCT02955797 Phase 3
25 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults 56 Years and Older Completed NCT02842866 Phase 3
26 Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02842853 Phase 3
27 Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02752906 Phase 3
28 Safety and Blood Donations in Adults Vaccinated With rMenB+OMV NZ. Completed NCT02305446 Phase 3
29 Antibody Persistence, and Safety and Tolerability of a Booster Dose of the Meningococcal B Vaccine After the Completion of the Vaccination Course in Study V72_28 Completed NCT01894919 Phase 3
30 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years Completed NCT01352793 Phase 3
31 Comparison of Two Meningococcal ACWY Conjugate Vaccines Completed NCT01192997 Phase 2, Phase 3
32 Evaluation of Meningococcal Immune Response Among Children Who Previously Received MenACWY Conjugate Vaccine Completed NCT01148017 Phase 3
33 Evaluation of Persistence of Anti-meningococcal Bactericidal Antibodies Among Adolescents Who Previously Received MenACWY Conjugate Vaccine Completed NCT00856297 Phase 3
34 Safety and Immunogenicity Evaluation After One or Two Doses of Novartis Meningococcal ACWY Conjugate Vaccine in Healthy Infants and Toddlers Completed NCT00667602 Phase 3
35 Immunogenicity, Safety and Lot to Lot Consistency of Novartis Meningococcal B Recombinant Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants Completed NCT00657709 Phase 3
36 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Infants Completed NCT00474526 Phase 3
37 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Healthy Adults Completed NCT00474487 Phase 3
38 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Conjugate Vaccine In US Adolescents and Adults Completed NCT00450437 Phase 3
39 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
40 Persistence of Antibody Levels and Response to Fifth or Third Meningococcal B Recombinant Vaccine in 4-year Old Healthy Children Who Previously Participated in Study V72P12E1 Completed NCT01717638 Phase 3
41 A Phase 3b Study to Assess the Safety of Novartis Meningococcal B Recombinant Vaccine When Administered in Healthy At-risk Adults Completed NCT01478347 Phase 3
42 Safety and Immunogenicity of Novartis Meningococcal B Vaccine Formulated With OMV Manufactured at Two Different Sites, in Healthy Adolescents Aged 11-17 Years Completed NCT01423084 Phase 3
43 A Phase 3B, Open Label, Multi-Center Study to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered Alone to Healthy Infants According to Different Immunization Schedules and to Healthy Chil Completed NCT01339923 Phase 3
44 Study of a Single Dose of Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects Completed NCT01519713 Phase 3
45 A Multi-center, Observer-blind, Placebo-controlled, Randomized Study to Evaluate the Immunogenicity and Safety of MenACWY in Adolescents and Adults in Korea Completed NCT01274897 Phase 3
46 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
47 Study to Evaluate the Safety and Immunogenicity of Combined Hepatitis A/B Vaccine With MenACWY-CRM Conjugate Vaccine Completed NCT01453348 Phase 3
48 Safety and Immunogenicity of 2 or 3 Doses of MenACWY Conjugate Vaccine in Healthy Infants and the Effects of a Booster Dose of MenACWY Administered in the Second Year of Life Completed NCT01214837 Phase 3
49 Assessment of Antibody Persistence at Eighteen Months After the Completion of the Vaccination Course in Study V72P10 Completed NCT01148524 Phase 2, Phase 3
50 Safety, Tolerability and Immunogenicity of Meningococcal B Recombinant Vaccine Administered as Booster Dose at 12, 18 or 24 Months of Age in Toddlers (12-24 Months) Primed With a Three-Dose Immunization Series as Infants in Study V72P12 Completed NCT00944034 Phase 2, Phase 3

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

38
Brain, Spinal Cord, Testes, Liver, Bone, Pituitary, Myeloid

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 766)
# Title Authors Year
1
Osmotic therapies added to antibiotics for acute bacterial meningitis. ( 29405037 )
2018
2
Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland. ( 29384979 )
2018
3
Elevations of novel cytokines in bacterial meningitis in infants. ( 29394248 )
2018
4
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
5
Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29188363 )
2018
6
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
7
The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: A clinical comparison with Ps. aeruginosa meningitis. ( 29310816 )
2018
8
Correction to: Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29322336 )
2018
9
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
10
Anaerobic bacterial meningitis in adults. ( 29396061 )
2018
11
Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Meditated Isothermal Amplification (TEC-LAMP) Assay for the Detection of Bacterial Meningitis Pathogens. ( 29425124 )
2018
12
Ectopic Prolactinoma Presenting as Bacterial Meningitis: A Diagnostic Conundrum. ( 29378345 )
2018
13
Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection. ( 29378166 )
2018
14
Bacterial meningitis antibiotic treatment. ( 29290234 )
2017
15
Recurrent CSF Rhinorrhea Misdiagnosed as Chronic Allergic Rhinitis with Subsequent Development of Bacterial Meningitis. ( 28819362 )
2017
16
Community-acquired bacterial meningitis. ( 27828810 )
2017
17
Evaluation of bacterial meningitis surveillance data of the northern region, Ghana, 2010-2015. ( 28904692 )
2017
18
Intraventricular administration of tigecycline for the treatment of multidrug-resistant bacterial meningitis after craniotomy: a case report. ( 28614982 )
2017
19
Early versus late diagnosis in community-acquired bacterial meningitis: a retrospective cohort study. ( 28652113 )
2017
20
Rapid detection of bacterial meningitis using a point-of-care glucometer. ( 28799985 )
2017
21
Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. ( 28049382 )
2017
22
CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens. ( 28915816 )
2017
23
Emergency Medicine Myths: Computed Tomography of the Head PriorA to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice? ( 28666562 )
2017
24
Dexamethasone treatment for bacterial meningitis in children: what is the truth? ( 29181964 )
2017
25
An L-2-Hydroxyglutaric Aciduria Case Presented With Acute Bacterial Meningitis. ( 28141777 )
2017
26
Assessment of healthcare delivery in the early management of bacterial meningitis in UK young infants: an observational study. ( 28827241 )
2017
27
Prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in Yunnan province, China, 2012-2015. ( 28662145 )
2017
28
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
29
Changes in the incidence of pneumonia, bacterial meningitis, and infant mortality 5 years following introduction of the 13-valent pneumococcal conjugate vaccine in a "3+0" schedule. ( 28813518 )
2017
30
Acute Bacterial Meningitis in Qatar: A Hospital-Based Study from 2009 to 2013. ( 28785577 )
2017
31
Frequency of acute bacterial meningitis in children with first episode of febrile seizures. ( 28770886 )
2017
32
Corrigendum to "Subdural Empyema Complicating Bacterial Meningitis: A Challenging Diagnosis in a Patient with Polysubstance Abuse". ( 29348757 )
2017
33
Cerebrospinal Fluid Rhinorrhea and Subsequent Bacterial Meningitis due to an Atypical Clival Fracture. ( 28717092 )
2017
34
Cerebrospinal Fluid Cathelicidin Correlates with the Bacterial Load and Outcomes in Childhood Bacterial Meningitis. ( 28827496 )
2017
35
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis. ( 29212462 )
2017
36
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
37
Response of Vancomycin according to Steroid Dosage in Pediatric Patients with Culture-Proven Bacterial Meningitis. ( 29299893 )
2017
38
Clinical Predictors of Malaria, Acute Bacterial Meningitis and Treatment Outcomes among Febrile Children Admitted with Altered Mental Status in Northwestern Tanzania. ( 29206991 )
2017
39
Comparison of enterovirus detection in cerebrospinal fluid with Bacterial Meningitis Score in children. ( 28767914 )
2017
40
Bacterial meningitis complicating the course of liver cirrhosis. ( 28616745 )
2017
41
An Unexpected Cause of Bradycardia in a Patient with Bacterial Meningitis. ( 28713431 )
2017
42
Is Bacterial Meningitis a Risk Factor for Developing Attention Deficit Hyperactivity Disorder. ( 29248907 )
2017
43
Bacterial meningitis due to Streptococcus pneumoniae following untreated idiopathic hypertrophic pachymeningitis. ( 28870586 )
2017
44
Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. ( 28077083 )
2017
45
Bacterial meningitis in alcoholic patients: A population-based prospective study. ( 28065808 )
2017
46
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention. ( 28925647 )
2017
47
Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis. ( 27057100 )
2016
48
Risk scores for outcome in bacterial meningitis: Systematic review and external validation study. ( 27519619 )
2016
49
Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study. ( 27816734 )
2016
50
Insights into seasonal dynamics of bacterial meningitis. ( 27198826 )
2016

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CFP CRP CXCL8 IL10 IL1B IL6
2
Show member pathways
13.4 CXCL8 IL10 IL1B IL6 TLR2 TLR9
3
Show member pathways
12.99 CXCL8 IL1B IL6 TLR2 TLR9 TNF
4
Show member pathways
12.85 CXCL8 IL10 IL1B IL6 TNF
5
Show member pathways
12.84 CFP CXCL8 IL1B IL6 TLR2 TLR9
6
Show member pathways
12.74 CXCL8 IL1B IL6 S100B TNF
7
Show member pathways
12.71 IL1B IL6 TLR2 TLR9 TNF
8
Show member pathways
12.62 IL10 IL1B IL6 TLR2 TNF
9
Show member pathways
12.6 CXCL8 IL6 MMP9 TLR2 TNF
10 12.59 IL10 IL1B TLR2 TLR9 TNF
11
Show member pathways
12.51 CXCL8 IL10 IL1B IL6 TLR2 TLR9
12
Show member pathways
12.43 IL10 IL1B IL6 TNF
13
Show member pathways
12.39 CXCL8 IL1B IL6 MMP9 TLR2 TNF
14
Show member pathways
12.37 ALB CRP IL1B IL6 TNF
15
Show member pathways
12.31 CXCL8 IL6 TLR2 TLR9 TNF
16
Show member pathways
12.29 CXCL8 IL1B IL6 TNF
17 12.28 IL10 IL1B IL6 TLR2 TLR9 TNF
18
Show member pathways
12.27 IL10 IL1B TLR2 TNF
19 12.24 IL6 MMP9 TLR2 TLR9 TNF
20 12.23 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.22 CXCL8 IL10 IL1B IL6 TNF
22
Show member pathways
12.22 CXCL8 IL1B IL6 TLR2 TLR9 TNF
23 12.08 CXCL8 IL1B IL6 MMP9 TNF
24
Show member pathways
12.06 IL1B PIK3C2A TLR2 TLR9
25 11.99 IL1B IL6 MMP9 TNF
26 11.95 CXCL8 IL1B IL6 TNF
27 11.93 CXCL8 IL1B IL6
28 11.92 CXCL8 IL1B IL6 TLR2 TNF
29
Show member pathways
11.9 MMP8 MMP9 TNF
30
Show member pathways
11.9 IL1B IL6 TLR2 TLR9
31 11.89 IL1B IL6 TNF
32 11.88 CXCL8 IL1B TNF
33 11.86 CXCL8 IL10 IL1B IL6 MMP9 TNF
34 11.84 CXCL8 IL10 IL1B IL6 TNF
35 11.83 CXCL8 IL1B IL6
36 11.8 IL10 IL1B IL6 TLR9 TNF
37 11.79 IL10 IL1B TNF
38
Show member pathways
11.75 IL10 IL1B IL6 TLR2 TLR9 TNF
39 11.71 IL10 IL6 TLR2 TLR9 TNF
40 11.69 CXCL8 IL6 MMP9
41 11.65 CXCL8 IL1B IL6 MMP9 TNF
42
Show member pathways
11.63 CXCL8 IL1B IL6 MMP9 TNF
43 11.62 CXCL8 IL10 IL1B IL6 TLR2 TNF
44 11.55 IL6 MMP9 TNF
45 11.55 IL1B TLR2 TNF
46 11.54 CXCL8 IL1B IL6 TLR2 TNF
47 11.52 IL1B IL6 TNF
48 11.46 CXCL8 IL10 IL1B IL6 TNF
49 11.44 IL10 IL1B IL6 TNF
50 11.38 CXCL8 IL6 MMP9

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CFP CRP CXCL8 IL10 IL1B
2 extracellular space GO:0005615 9.47 ALB CFP CKB CRP CXCL8 IL10
3 tertiary granule lumen GO:1904724 9.33 CFP MMP8 MMP9

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 CRP IL1B IL6 TLR2 TLR9 TNF
2 defense response to bacterium GO:0042742 9.96 CFP IL10 TLR9 TNF
3 immune response GO:0006955 9.95 CFP CXCL8 IL10 IL1B IL6 TLR2
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1B S100B TLR9 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 IL10 IL6 TNF
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.86 IL10 IL1B IL6 TNF
7 positive regulation of JNK cascade GO:0046330 9.84 IL1B TLR9 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TLR2 TNF
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B IL6 TLR2 TLR9 TNF
10 response to glucocorticoid GO:0051384 9.8 IL10 IL6 S100B TNF
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 IL1B TLR2 TNF
12 negative regulation of interleukin-6 production GO:0032715 9.72 IL10 TLR9 TNF
13 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.71 IL10 MMP9 TNF
14 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
15 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
16 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.68 TLR2 TLR9
18 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR9
19 regulation of cytokine secretion GO:0050707 9.67 TLR2 TLR9
20 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 IL1B TLR9
21 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TLR2 TLR9 TNF
22 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
23 endothelial cell apoptotic process GO:0072577 9.66 IL10 TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 IL1B TNF
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.64 IL10 TNF
27 negative regulation of interleukin-8 production GO:0032717 9.64 IL10 TLR9
28 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
29 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
30 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
31 positive regulation of NF-kappaB import into nucleus GO:0042346 9.62 IL1B TLR2 TLR9 TNF
32 positive regulation of interleukin-18 production GO:0032741 9.61 TLR2 TLR9
33 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
34 positive regulation of toll-like receptor signaling pathway GO:0034123 9.6 TLR2 TLR9
35 receptor biosynthetic process GO:0032800 9.59 IL10 TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.58 IL1B TNF
37 positive regulation of chemokine production GO:0032722 9.56 IL6 TLR2 TLR9 TNF
38 response to molecule of bacterial origin GO:0002237 9.46 CXCL8 IL10 TLR2 TLR9
39 positive regulation of interleukin-6 production GO:0032755 9.35 IL1B IL6 TLR2 TLR9 TNF
40 inflammatory response GO:0006954 9.23 CRP CXCL8 IL10 IL1B IL6 TLR2
41 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 IL10 IL1B IL6 TLR2 TLR9 TNF
42 regulation of receptor activity GO:0010469 10.04 CXCL8 IL10 IL1B IL6 TNF
43 negative regulation of cell proliferation GO:0008285 10.03 CXCL8 IL10 IL1B IL6 TLR2

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL6 TNF

Sources for Bacterial Meningitis

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