MCID: BCT007
MIFTS: 54

Bacterial Meningitis malady

Neuronal diseases category

Summaries for Bacterial Meningitis

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3CDC, 32MalaCards
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CDC:3 Bacterial meningitis is usually severe. While most people with meningitis recover, it can cause serious complications, such as brain damage, hearing loss, or learning disabilities.

MalaCards: Bacterial Meningitis, also known as meningitis, bacterial, is related to meningitis and viral meningitis. An important gene associated with Bacterial Meningitis is CFP (complement factor properdin), and among its related pathways are Passive Transport by Aquaporins and Spinal Cord Injury. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are hematopoietic system and skeleton.

Aliases & Classifications for Bacterial Meningitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bacterial meningitis 8 42
meningitis, bacterial 42 60
meningitis bacterial 44


External Ids:

Disease Ontology8 DOID:9470
ICD9CM27 320, 320.9
MeSH34 D016920
ICD1025 G00

Related Diseases for Bacterial Meningitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Viral Meningitis family:

bacterial meningitis Chronic Meningitis
Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis32.0MBL2, CRP, CFP, FCGR2A, ADA, LYZ
2viral meningitis30.7CRP, ADA
3aseptic meningitis30.7GUSB, ADA
4hydrocephalus30.6AQP4, AQP1, NTF3
5pneumonia30.4MBL2, CRP, CXCL5, IL17A, MMP8, C3AR1
6myeloma30.3MMP8
7encephalitis30.3IL17A, C3AR1, AQP4
8tuberculosis30.3TLR9, MBL2, GUSB, CRP, IL17A, ADA
9malaria30.2TLR9, CFP, FCGR2A
10arthritis30.2GUSB, CRP, CXCL5, IL17A, MMP8, FCGR2A
11complement deficiency30.2CFP, MBL2
12uveitis29.9IL17A
13tonsillitis29.9CRP
14histiocytosis29.9LYZ
15skin disease29.9LYZ
16lupus erythematosus29.9CFP, TLR9
17otitis media29.9MBL2
18liver cirrhosis29.9ADA, GUSB
19pancreatitis29.9CRP
20systemic lupus erythematosus29.9CRP, FCGR2A
21thrombocytopenia29.9FCGR2A, GUSB
22peritonitis29.9AQP1, ADA, MMP8, CRP
23ischemia29.9CKB, NTF3, IL17A, AQP4
24multiple sclerosis29.9MBL2, IL17A, MMP8, C3AR1, AQP4
25cerebritis10.6
26influenza10.4
27neuronitis10.3
28obstructive hydrocephalus10.3
29pituitary apoplexy10.2
30meningocele10.2
31endophthalmitis10.2
32multiple myeloma10.2
33epidural abscess10.1
34subdural empyema10.1
35cerebral arteritis10.1
36cortical blindness10.1
37cauda equina syndrome10.1
38listeria meningitis10.1
39streptococcal meningitis10.1
40communicating hydrocephalus10.1
41cranial nerve palsy10.1
42endocarditis10.1
43pneumococcal meningitis10.1
44hepatitis10.0GUSB
45galactosemia10.0CRP
46keratitis10.0IL17A
47extrapulmonary tuberculosis10.0ADA
48sickle cell disease10.0GUSB
49dental caries10.0MMP8
50ankylosing spondylitis10.0CRP

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to bacterial meningitis

Clinical Features for Bacterial Meningitis

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Drugs & Therapeutics for Bacterial Meningitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bacterial Meningitis

Drug clinical trials:

Search ClinicalTrials for Bacterial Meningitis

Search NIH Clinical Center for Bacterial Meningitis

Search CenterWatch for Bacterial Meningitis

Genetic Tests for Bacterial Meningitis

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Anatomical Context for Bacterial Meningitis

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32MalaCards
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MalaCards organs/tissues related to Bacterial Meningitis:

32
Brain, Testes, Pituitary, Myeloid, Liver, Pineal, T cells, Tonsil, Prostate, Skin, Kidney, Spinal cord, Bone

Animal Models for Bacterial Meningitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Bacterial Meningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.9MBL2, GUSB, IL17A, FCGR2A, C3AR1, ADA
2MP:00053909.9GUSB, PGLYRP2, CFP, C3AR1
3MP:00053679.9TLR9, MBL2, GUSB, IL17A, ADA, AQP1
4MP:00053879.8AQP4, TLR9, MBL2, CRP, GBP1, PGLYRP2
5MP:00053769.7NTF3, CRP, GUSB, MBL2, TLR9, PGLYRP2
6MP:00107689.6PGLYRP2, GBP1, NTF3, GUSB, TLR9, IL17A

Publications for Bacterial Meningitis

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Sources:
50PubMed
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Articles related to Bacterial Meningitis:

(show top 50)    (show all 686)
idTitleAuthorsYear
1
Cerebrospinal Fluid TNF-I+, IL-6, and IL-8 in Children With Bacterial Meningitis. (24138950)
2014
2
Association of treatment for bacterial meningitis with the development of sequelae. (23537920)
2013
3
Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis. (23053059)
2013
4
Computational approaches to identify common subunit vaccine candidates against bacterial meningitis. (23740398)
2013
5
Bacterial meningitis in children in Iceland, 1975-2010: a nationwide epidemiological study. (23968225)
2013
6
Prospective multi-centre sentinel surveillance for Haemophilus influenzae type b & other bacterial meningitis in Indian children. (23703338)
2013
7
Diagnostic lumbar puncture in suspected acute bacterial meningitis: avoiding catastrophe. (24219424)
2013
8
Omp85 genosensor for detection of human brain bacterial meningitis. (23471585)
2013
9
rmpM genosensor for detection of human brain bacterial meningitis in cerebrospinal fluid. (23824531)
2013
10
The clinical diagnostic significance of cerebrospinal fluid D-lactate for bacterial meningitis. (22713513)
2012
11
Factors influencing neurological outcome of children with bacterial meningitis at the emergency department. (22527566)
2012
12
Diagnosis and management of bacterial meningitis in the paediatric population: a review. (23050153)
2012
13
Cerebrospinal fluid (CSF) lactic acid levels: a rapid and reliable way to differentiate viral from bacterial meningitis or concurrent viral/bacterial meningitis. (22203753)
2012
14
Factors for poor prognosis of neonatal bacterial meningitis in a medical center in Northern Taiwan. (22571998)
2012
15
Acute community-acquired bacterial meningitis in adults: an evidence-based review. (22660870)
2012
16
Clinical characteristics, pathogens implicated and therapeutic outcomes of mixed infection in adult bacterial meningitis. (23089318)
2012
17
Bacterial meningitis: a new risk factor. (22091233)
2011
18
5 versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study. (21620467)
2011
19
'One for all' concerns regarding NICE antibiotic guidelines on suspected bacterial meningitis! (22152829)
2011
20
Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. (21186256)
2011
21
Bacterial meningitis and septicemia of neonate due to Lactococcus lactis. (21342341)
2011
22
Clinical characteristics and prognosis of acute bacterial meningitis in elderly patients over 65: a hospital-based study. (22204457)
2011
23
Cerebral malaria and bacterial meningitis. (21847328)
2011
24
Antibiotic treatment for bacterial meningitis caused by Listeria monocytogenes in a patient with multiple myeloma. (20112040)
2010
25
Nosocomial bacterial meningitis. (20375416)
2010
26
Extreme hypoglycorrhachia: not always bacterial meningitis. (20842184)
2010
27
Oxidative stress and myeloperoxidase activity during bacterial meningitis: effects of febrile episodes and the BBB permeability. (19822138)
2010
28
Bilateral endophthalmitis as the initial presentation of bacterial meningitis. (20046699)
2009
29
Direct analysis of clinical relevant single bacterial cells from cerebrospinal fluid during bacterial meningitis by means of micro-Raman spectroscopy. (19343686)
2009
30
Application of 16S rDNA based seminested PCR for diagnosis of acute bacterial meningitis. (19293446)
2009
31
Treatment of bacterial meningitis: an overview of Cochrane systematic reviews. (19375903)
2009
32
Adult community-acquired bacterial meningitis requiring ICU admission: epidemiological data, prognosis factors and adherence to IDSA guidelines. (19727871)
2009
33
Diagnosis and management of adult bacterial meningitis. (19537568)
2009
34
EFNS guideline on the management of community-acquired bacterial meningitis: report of an EFNS Task Force on acute bacterial meningitis in older children and adults. (18582342)
2008
35
Fatal recurrent bacterial meningitis: a complication of chronic Strongyloides infection. (18848169)
2008
36
A prospective study of etiology of childhood acute bacterial meningitis, Turkey. (18598630)
2008
37
Corticosteroids for bacterial meningitis. (18376431)
2008
38
Bilateral endophthalmitis in a patient with bacterial meningitis caused by Streptococcus pneumoniae. (18685258)
2008
39
Neuro-BehAsets/neuro-Sweets disease presents simultaneously with severe tonsillitis, and features mimicking bacterial meningitis with skin lesions. (17170507)
2006
40
Bacterial penetration across the blood-brain barrier during the development of neonatal meningitis. (11008113)
2000
41
Acute obstructive hydrocephalus complicating bacterial meningitis. Neuroimaging has limitations. (10068236)
1999
42
Oxidative stress in bacterial meningitis. (9989452)
1999
43
The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. (9531317)
1998
44
Bacterial meningitis and CSF cytokines]. (15034315)
1997
45
Diffusion of 3-quaternary ammonium cephem antibiotics into cerebrospinal fluid of patients with bacterial meningitis. (8738850)
1996
46
The significance of elevated Mn SOD level in cerebrospinal fluid of patients with bacterial meningitis--its relation to cytokine]. (8026125)
1994
47
Cerebrospinal fluid interleukin-6 and IgE in bacterial and viral meningitis. (1580206)
1992
48
Serum C-reactive protein vs. tumor necrosis factor alpha and interleukin 1 beta of the cerebrospinal fluid in diagnosis of bacterial meningitis with low cerebrospinal fluid cell count. (1461699)
1992
49
C-reactive protein in case of consecutive bacterial and viral meningitis. (6151070)
1984
50
Meningitis and hemiplegia marking the on set of subacute bacterial endocarditis. (14899703)
1952

Genetic Variations for Bacterial Meningitis

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Expression for genes affiliated with Bacterial Meningitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for genes affiliated with Bacterial Meningitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Bacterial Meningitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3AQP4, AQP1
210.3AQP4, AQP1, FCGR2A
3
Immune response Lectin induced complement pathway
Hide members
10.2MBL2, CRP, CFP, C3AR1
410.2C3AR1, FCGR2A, FPR2, MBL2

Compounds for genes affiliated with Bacterial Meningitis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.8CXCL5
2pge24410.8FPR2
3mannitol44 1111.8CRP, AQP4
4forskolin44 49 1112.7NTF3, CKB
5mannan4410.7CFP, IL17A, MBL2
6Alpha-D-Mannose1110.6LYZ, GUSB, MBL2
7etanercept44 49 1112.6CRP, IL17A, FCGR2A
8lactulose4410.6GUSB, CRP
9vitamin b124410.6ADA, CRP, GUSB
10peptidoglycan44 2811.6TLR9, MBL2, PGLYRP2
11neopterin4410.6MBL2, CRP, ADA
122 chloroadenosine4410.6NTF3, ADA
13mannose4410.6MBL2, IL17A, CFP, FCGR2A
14rantes4410.6IL17A, CXCL5, MBL2
15aspirin44 49 28 2413.6GUSB, CRP, FPR2, ADA
16oxygen44 2411.6MMP8, FPR2, MBL2
17hydroxychloroquine44 1111.5TLR9, CRP
18amide4410.5MBL2, PGLYRP2, MMP8
19fmlp4410.5GUSB, CXCL5, FPR2, FCGR2A, C3AR1, ADA
20aspartate4410.5CKB, MBL2, GUSB, NTF3, ADA
21lactate4410.5CKB, GUSB, CRP, MMP8, ADA
22leukotriene b444 59 2412.5FPR2, CXCL5, GUSB
23vas-a4410.5AQP4, AQP1
24histamine44 28 2412.5AQP4, GUSB, NTF3, FPR2, FCGR2A, C3AR1
25dexamethasone44 49 28 1113.4MBL2, CXCL5, IL17A, FPR2, ADA, AQP1
26sodium44 2411.4CKB, MBL2, NTF3, AQP1, AQP4
27superoxide44 2411.4MBL2, GUSB, NTF3, CXCL5, FPR2, MMP8
28acetylcholine44 49 28 11 2414.4GUSB, NTF3, ADA
29cysteine4410.4MBL2, NTF3, MMP8, CFP, ADA, AQP1
30creatinine4410.4CKB, MBL2, GUSB, CRP, IL17A, ADA
31glucose4410.4AQP1, MMP8, NTF3, CKB
32nitric oxide44 11 2412.4TLR9, MBL2, NTF3, CXCL5, IL17A, MMP8
33oligonucleotide4410.4TLR9, CXCL5, IL17A, FPR2, MMP8, FCGR2A
34progesterone44 59 28 11 2414.3CKB, MBL2, NTF3, CXCL5, MMP8
35vegf4410.3MBL2, CRP, NTF3, CXCL5, IL17A, MMP8
36serine4410.3C3AR1, FCGR2A, MMP8
37lipid4410.3MBL2, CRP, IL17A, FPR2, MMP8, FCGR2A
38tyrosine4410.3TLR9, MBL2, NTF3, CXCL5, IL17A, FPR2
39p0024410.3MMP8, IL17A, CRP
40ly2940024410.2CRP, NTF3, IL17A, FCGR2A
41calcium44 49 11 2413.1CKB, MBL2, GUSB, CRP, NTF3, CXCL5
42tuberculin4410.1ADA, MBL2
43steroid4410.0CKB, MBL2, NTF3, IL17A, AQP1

GO Terms for genes affiliated with Bacterial Meningitis

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Sources:
16Gene Ontology
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Cellular components related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.0CRP, CXCL5, IL17A, MMP8, CFP, ADA
2extracellular regionGO:0055769.5LYZ, TLR9, MBL2, CRP, NTF3, GBP1

Biological processes related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.4AQP1, AQP4
2defense response to bacteriumGO:04274210.4TLR9, MBL2, CFP, LYZ
3defense response to Gram-positive bacteriumGO:05083010.4MBL2, CRP, PGLYRP2
4carbon dioxide transportGO:01567010.3AQP4, AQP1
5chemotaxisGO:00693510.3C3AR1, FPR2, CXCL5
6inflammatory responseGO:00695410.3LYZ, C3AR1, FPR2, IL17A, CRP, TLR9
7opsonizationGO:00822810.2CRP, MBL2
8innate immune responseGO:0450879.8TLR9, MBL2, PGLYRP2, CFP, FCGR2A

Molecular functions related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-formyl peptide receptor activityGO:00498210.4C3AR1, FPR2
2water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Bacterial Meningitis

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  • Antibodies
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Sources for Bacterial Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet