MCID: BCT007
MIFTS: 54

Bacterial Meningitis malady

Neuronal diseases category

Summaries for Bacterial Meningitis

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3CDC, 32MalaCards
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CDC:3 Bacterial meningitis is usually severe. While most people with meningitis recover, it can cause serious complications, such as brain damage, hearing loss, or learning disabilities.

MalaCards: Bacterial Meningitis, also known as meningitis, bacterial, is related to meningitis and viral meningitis. An important gene associated with Bacterial Meningitis is CFP (complement factor properdin), and among its related pathways are Passive Transport by Aquaporins and Spinal Cord Injury. The compounds endotoxin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related mouse phenotypes are hematopoietic system and skeleton.

Aliases & Classifications for Bacterial Meningitis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bacterial meningitis 8 42
meningitis, bacterial 42 60
meningitis bacterial 44


External Ids:

Disease Ontology8 DOID:9470
ICD9CM27 320, 320.9
MeSH34 D016920
ICD1025 G00

Related Diseases for Bacterial Meningitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Viral Meningitis family:

bacterial meningitis Chronic Meningitis
Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1meningitis32.0MBL2, CRP, CFP, FCGR2A, ADA, LYZ
2viral meningitis30.7CRP, ADA
3aseptic meningitis30.7GUSB, ADA
4hydrocephalus30.6AQP4, AQP1, NTF3
5pneumonia30.4MBL2, CRP, CXCL5, IL17A, MMP8, C3AR1
6myeloma30.3MMP8
7encephalitis30.3IL17A, C3AR1, AQP4
8tuberculosis30.3TLR9, MBL2, GUSB, CRP, IL17A, ADA
9malaria30.2TLR9, CFP, FCGR2A
10arthritis30.2GUSB, CRP, CXCL5, IL17A, MMP8, FCGR2A
11complement deficiency30.2CFP, MBL2
12uveitis29.9IL17A
13tonsillitis29.9CRP
14histiocytosis29.9LYZ
15skin disease29.9LYZ
16lupus erythematosus29.9CFP, TLR9
17otitis media29.9MBL2
18liver cirrhosis29.9ADA, GUSB
19pancreatitis29.9CRP
20systemic lupus erythematosus29.9CRP, FCGR2A
21thrombocytopenia29.9FCGR2A, GUSB
22peritonitis29.9AQP1, ADA, MMP8, CRP
23ischemia29.9CKB, NTF3, IL17A, AQP4
24multiple sclerosis29.9MBL2, IL17A, MMP8, C3AR1, AQP4
25cerebritis10.6
26influenza10.4
27neuronitis10.3
28obstructive hydrocephalus10.3
29pituitary apoplexy10.2
30meningocele10.2
31endophthalmitis10.2
32multiple myeloma10.2
33epidural abscess10.1
34subdural empyema10.1
35cerebral arteritis10.1
36cortical blindness10.1
37cauda equina syndrome10.1
38listeria meningitis10.1
39streptococcal meningitis10.1
40communicating hydrocephalus10.1
41cranial nerve palsy10.1
42endocarditis10.1
43pneumococcal meningitis10.1
44hepatitis10.0GUSB
45galactosemia10.0CRP
46keratitis10.0IL17A
47extrapulmonary tuberculosis10.0ADA
48sickle cell disease10.0GUSB
49dental caries10.0MMP8
50ankylosing spondylitis10.0CRP

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to bacterial meningitis

Clinical Features for Bacterial Meningitis

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Drugs & Therapeutics for Bacterial Meningitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bacterial Meningitis

Drug clinical trials:

Search ClinicalTrials for Bacterial Meningitis

Search NIH Clinical Center for Bacterial Meningitis

Search CenterWatch for Bacterial Meningitis

Genetic Tests for Bacterial Meningitis

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Anatomical Context for Bacterial Meningitis

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32MalaCards
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MalaCards organs/tissues related to Bacterial Meningitis:

32
Brain, Testes, Pituitary, Myeloid, Liver, Tonsil, Prostate, T cells, Kidney, Spinal cord, Bone, Skin, Pineal

Animal Models for Bacterial Meningitis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Bacterial Meningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.9TLR9, GUSB, IL17A, FCGR2A, C3AR1, ADA
2MP:00053909.9CFP, PGLYRP2, GUSB, C3AR1
3MP:00053679.9TLR9, AQP4, AQP1, ADA, IL17A, GUSB
4MP:00053879.8GBP1, CRP, AQP4, ADA, C3AR1, TLR9
5MP:00053769.7AQP4, TLR9, MBL2, GUSB, CRP, NTF3
6MP:00107689.6ADA, TLR9, GBP1, AQP4, AQP1, C3AR1

Publications for Bacterial Meningitis

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50PubMed
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Articles related to Bacterial Meningitis:

(show top 50)    (show all 686)
idTitleAuthorsYear
1
Spontaneous coronary artery dissection in a patient with bacterial meningitis. (24194165)
2013
2
Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis. (23910166)
2013
3
The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982-2010). (23168216)
2013
4
Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients. (24155161)
2013
5
Acute bacterial meningitis with coincident methamphetamine use: a case report and review of the literature. (23601243)
2013
6
Effect of vaccines on bacterial meningitis worldwide. (23141619)
2012
7
Clinical features and course of bacterial meningitis in children. (23272517)
2012
8
Cerebral infarction in adults with bacterial meningitis. (21989842)
2012
9
Adult zebrafish model of bacterial meningitis in Streptococcus agalactiae infection. (22867759)
2012
10
Recurrent bacterial meningitis in a child with hearing impairment, mondini dysplasia: a case report. (23456530)
2012
11
Dexamethasone for adult community-acquired bacterial meningitis: 20 years of experience in daily practice. (21706150)
2012
12
Use of corticosteroids and other adjunct therapies for acute bacterial meningitis in adults. (22678778)
2012
13
5 versus 10 days of ceftriaxone for bacterial meningitis in children. (22055038)
2011
14
Slow initial I^-lactam infusion and oral paracetamol to treat childhood bacterial meningitis: a randomised, controlled trial. (21550313)
2011
15
Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae. (22170227)
2011
16
Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. (21149592)
2011
17
Several clinical signs and symptoms are associated with the likelihood of bacterial meningitis in children; the most reliable diagnostic combination is uncertain. (21354985)
2011
18
Unexpected non-seasonal increase of bacterial meningitis cases in Georgia in 2009. (20834075)
2010
19
Cognitive functioning and quality of life nine years after bacterial meningitis. (20659499)
2010
20
Therapeutic management of bacterial meningitis in children: a systematic review and comparison of published guidelines from a European perspective. (20685625)
2010
21
Recurrent bacterial meningitis after cochlear implantation in a patient with a newly described labyrinthine malformation. (19027967)
2009
22
Burden and etiology of community-acquired bacterial meningitis in a hospital in Eastern Saudi Arabia: 1993-2005. (19179978)
2009
23
Simvastatin attenuates leukocyte recruitment in experimental bacterial meningitis. (19130904)
2009
24
Incidence of bacterial meningitis (2001-2005) in Lazio, Italy: the results of a integrated surveillance system. (19196453)
2009
25
Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis. (19411436)
2009
26
Circulating levels of vasoactive peptides in patients with acute bacterial meningitis. (19513693)
2009
27
Aseptic meningitis with relapsing polychondritis mimicking bacterial meningitis. (19834279)
2009
28
Corticosteroids for acute bacterial meningitis. (19541051)
2009
29
Battling bacterial meningitis in developing countries. (18565445)
2008
30
Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. (18829794)
2008
31
Follow-up of cochlear implant use in patients who developed bacterial meningitis following cochlear implantation. (18528310)
2008
32
Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study. (19047543)
2008
33
Corticosteroids for bacterial meningitis. (18376430)
2008
34
Steroids for bacterial meningitis in children? (18309795)
2007
35
Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis. (16948860)
2006
36
Sleep disorders are long-term sequelae of both bacterial and viral meningitis. (16543543)
2006
37
Accuracy of clinical presentation for differentiating bacterial from viral meningitis in adults: a multivariate approach. (16244879)
2005
38
What's the difference between bacterial and viral meningitis? (15017944)
2004
39
Expression of death-related proteins in dentate granule cells in human bacterial meningitis. (11556687)
2001
40
Rapid diagnosis of the type of meningitis (bacterial or viral) by the assay of serum procalcitonin]. (10776411)
2000
41
Procalcitonin, C-reactive protein and interleukin 6 in bacterial and viral meningitis in children]. (9767794)
1998
42
C-reactive protein as an indicator of complications in bacterial meningitis. (8979584)
1996
43
Nosocomial bacterial and fungal meningitis in cancer patients. (8564349)
1995
44
High levels of interleukin 10 and tumor necrosis factor alpha in cerebrospinal fluid during the onset of bacterial meningitis. (7578738)
1995
45
Subdural empyema complicating bacterial meningitis in a child: enhancement of membranes with gadolinium on magnetic resonance imaging in a patient without enhancement on computed tomography. (1347665)
1992
46
Cerebrospinal fluid levels of lysozyme, IgM and C-reactive protein in the identification of bacterial meningitis. (1560489)
1992
47
Cerebrospinal fluid cachectin/tumor necrosis factor-alpha and platelet-activating factor concentrations and severity of bacterial meningitis in children. (2355190)
1990
48
Detection of bacterial antigens in cerebrospinal fluid by a latex agglutination test in 'septic unknown' meningitis and serogroup B meningococcal meningitis. (2772770)
1989
49
Pathophysiological mechanisms in pyogenic infections: two examples--pleural empyema and acute bacterial meningitis. (7121472)
1982
50
An appraisal of vitamin C in adjunct therapy of bacterial and "viral" meningitis. (408071)
1977

Genetic Variations for Bacterial Meningitis

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Expression for genes affiliated with Bacterial Meningitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for genes affiliated with Bacterial Meningitis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG
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Pathways related to Bacterial Meningitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3AQP4, AQP1
210.3FCGR2A, AQP1, AQP4
3
Immune response Lectin induced complement pathway
Hide members
10.2MBL2, CRP, CFP, C3AR1
410.2MBL2, FPR2, FCGR2A, C3AR1

Compounds for genes affiliated with Bacterial Meningitis

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1endotoxin4410.8CXCL5
2pge24410.8FPR2
3mannitol44 1111.8CRP, AQP4
4forskolin44 49 1112.7NTF3, CKB
5mannan4410.7CFP, IL17A, MBL2
6Alpha-D-Mannose1110.6LYZ, GUSB, MBL2
7etanercept44 49 1112.6CRP, IL17A, FCGR2A
8lactulose4410.6GUSB, CRP
9vitamin b124410.6ADA, CRP, GUSB
10peptidoglycan44 2811.6TLR9, MBL2, PGLYRP2
11neopterin4410.6MBL2, CRP, ADA
122 chloroadenosine4410.6NTF3, ADA
13mannose4410.6MBL2, IL17A, CFP, FCGR2A
14rantes4410.6IL17A, CXCL5, MBL2
15aspirin44 49 28 2413.6GUSB, CRP, FPR2, ADA
16oxygen44 2411.6MMP8, FPR2, MBL2
17hydroxychloroquine44 1111.5TLR9, CRP
18amide4410.5MBL2, PGLYRP2, MMP8
19fmlp4410.5GUSB, CXCL5, FPR2, FCGR2A, C3AR1, ADA
20aspartate4410.5CKB, MBL2, GUSB, NTF3, ADA
21lactate4410.5CKB, GUSB, CRP, MMP8, ADA
22leukotriene b444 59 2412.5FPR2, CXCL5, GUSB
23vas-a4410.5AQP4, AQP1
24histamine44 28 2412.5AQP4, GUSB, NTF3, FPR2, FCGR2A, C3AR1
25dexamethasone44 49 28 1113.4MBL2, CXCL5, IL17A, FPR2, ADA, AQP1
26sodium44 2411.4CKB, MBL2, NTF3, AQP1, AQP4
27superoxide44 2411.4MBL2, GUSB, NTF3, CXCL5, FPR2, MMP8
28acetylcholine44 49 28 11 2414.4GUSB, NTF3, ADA
29cysteine4410.4MBL2, NTF3, MMP8, CFP, ADA, AQP1
30creatinine4410.4CKB, MBL2, GUSB, CRP, IL17A, ADA
31glucose4410.4AQP1, MMP8, NTF3, CKB
32nitric oxide44 11 2412.4TLR9, MBL2, NTF3, CXCL5, IL17A, MMP8
33oligonucleotide4410.4TLR9, CXCL5, IL17A, FPR2, MMP8, FCGR2A
34progesterone44 59 28 11 2414.3CKB, MBL2, NTF3, CXCL5, MMP8
35vegf4410.3MBL2, CRP, NTF3, CXCL5, IL17A, MMP8
36serine4410.3C3AR1, FCGR2A, MMP8
37lipid4410.3MBL2, CRP, IL17A, FPR2, MMP8, FCGR2A
38tyrosine4410.3TLR9, MBL2, NTF3, CXCL5, IL17A, FPR2
39p0024410.3MMP8, IL17A, CRP
40ly2940024410.2CRP, NTF3, IL17A, FCGR2A
41calcium44 49 11 2413.1CKB, MBL2, GUSB, CRP, NTF3, CXCL5
42tuberculin4410.1ADA, MBL2
43steroid4410.0CKB, MBL2, NTF3, IL17A, AQP1

GO Terms for genes affiliated with Bacterial Meningitis

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16Gene Ontology
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Cellular components related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.0CRP, CXCL5, IL17A, MMP8, CFP, ADA
2extracellular regionGO:0055769.5LYZ, TLR9, MBL2, CRP, NTF3, GBP1

Biological processes related to Bacterial Meningitis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal water homeostasisGO:05089110.4AQP4, AQP1
2defense response to bacteriumGO:04274210.4MBL2, TLR9, LYZ, CFP
3defense response to Gram-positive bacteriumGO:05083010.4CRP, PGLYRP2, MBL2
4carbon dioxide transportGO:01567010.3AQP1, AQP4
5chemotaxisGO:00693510.3CXCL5, FPR2, C3AR1
6inflammatory responseGO:00695410.3CRP, LYZ, C3AR1, FPR2, IL17A, TLR9
7opsonizationGO:00822810.2CRP, MBL2
8innate immune responseGO:0450879.8TLR9, MBL2, PGLYRP2, CFP, FCGR2A

Molecular functions related to Bacterial Meningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1N-formyl peptide receptor activityGO:00498210.4C3AR1, FPR2
2water transmembrane transporter activityGO:00537210.0AQP4, AQP1

Products for genes affiliated with Bacterial Meningitis

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Sources for Bacterial Meningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet