MCID: BCT007
MIFTS: 54

Bacterial Meningitis malady

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Bacterial Meningitis

Aliases & Descriptions for Bacterial Meningitis:

Name: Bacterial Meningitis 12 50 3 14
Meningitis, Bacterial 50 42 69
Meningitis Bacterial 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD10 33 G00 G00.9
ICD9CM 35 320 320.9
MeSH 42 D016920
NCIt 47 C118297
UMLS 69 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Español: Meningitis bacteriana

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to aseptic meningitis and tuberculosis. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Amphotericin B have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
id Related Disease Score Top Affiliating Genes
1 aseptic meningitis 30.2 TLR2 TLR4 TNF
2 tuberculosis 29.9 IL10 IL1B TLR9 TNF
3 spotted fever 29.6 TLR2 TLR4 TNF
4 histiocytosis 28.8 CRP CXCL8 IL1B MMP8 MMP9 TLR2
5 meningitis 11.6
6 haemophilus meningitis 11.4
7 cerebral palsy 10.8
8 meningococcal meningitis 10.8
9 pneumococcal meningitis 10.5
10 streptococcal meningitis 10.5
11 intussusception 10.4 IL1B TNF
12 pyridoxal 5'-phosphate-dependent epilepsy 10.4 IL10 TNF
13 tubular renal disease-cardiomyopathy syndrome 10.3 IL10 TNF
14 human immunodeficiency virus infectious disease 10.3 CRP IL1B TNF
15 myeloid proliferations related to down syndrome 10.3 CXCL8 TLR2
16 gonococcal endophthalmia 10.3 IL10 IL1B TNF
17 ectodermal dysplasia bartalos type 10.3 IL10 IL1B TNF
18 benign neonatal seizures 10.3 CRP IL1B TNF
19 bladder signet ring cell adenocarcinoma 10.3 IL10 IL1B TNF
20 conidiobolomycosis 10.3 CXCL8 IL10 TNF
21 pyloric stenosis, infantile hypertrophic, 2 10.3 CRP IL1B TNF
22 amyotrophic lateral sclerosis type 14 10.3 CXCL8 IL1B TNF
23 plantar wart 10.3 CXCL8 IL10 TNF
24 childhood electroclinical syndrome 10.3 CXCL8 IL10 IL1B
25 central nervous system lymphoma 10.3 IL10 IL1B TNF
26 hypersensitivity reaction type iii disease 10.3 CXCL8 MMP9
27 tularemia 10.3 IL10 TLR9 TNF
28 acquired thrombocytopenia 10.3 CXCL8 IL1B TNF
29 patau syndrome 10.3 CRP IL1B TNF
30 gastric dilatation 10.3 CXCL8 IL10 TNF
31 pancreas lymphoma 10.3 CRP IL1B TNF
32 congenital hypothyroidism 10.3 IL10 TLR2 TNF
33 cicatricial lagophthalmos 10.3 CRP CXCL8 TNF
34 erb-duchenne and dejerine-klumpke palsies 10.3 CXCL8 IL10 TNF
35 hidradenitis 10.3 CRP CXCL8 IL1B
36 nasal cavity cancer 10.3 CXCL8 IL1B TNF
37 tuberculous peritonitis 10.3 IL10 TLR9 TNF
38 microcephaly 10.3 IL10 TLR2 TNF
39 handl syndrome 10.3 CXCL8 TLR2 TNF
40 strawberry gallbladder 10.3 CRP CXCL8 TNF
41 ulcerative proctitis 10.3 CXCL8 TLR2 TNF
42 oral cavity carcinoma in situ 10.3 IL10 IL1B TLR2
43 wilkes stevenson syndrome 10.3 CRP CXCL8 IL1B
44 mycoplasmal pneumonia 10.3 CXCL8 TLR2 TNF
45 motor peripheral neuropathy 10.3 IL10 TLR9 TNF
46 autoimmune disease of central nervous system 10.3 CRP TLR2 TNF
47 skin conditions 10.3 CXCL8 IL1B TNF
48 alcoholic hepatitis 10.2 CXCL8 IL10 TNF
49 disease of mental health 10.2 IL10 TLR2 TNF
50 central epithelioid sarcoma 10.2 CRP MMP9 TNF

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 TLR4 IL1B TLR9 MMP8 TNF MMP9
2 immune system MP:0005387 10 TLR4 IL1B TLR9 MMP8 TNF MMP9
3 digestive/alimentary MP:0005381 9.91 TLR4 TLR9 TNF MMP9 ALB TLR2
4 integument MP:0010771 9.76 TLR4 IL1B TNF MMP9 PTGDS S100B
5 neoplasm MP:0002006 9.61 IL1B MMP8 TNF MMP9 PTGDS ALB
6 skeleton MP:0005390 9.23 TLR4 IL1B TNF MMP9 PTGDS CFP

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 246)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 14956 5280965
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Azathioprine Approved Phase 4 446-86-6 2265
7
Ceftriaxone Approved Phase 4,Phase 1 73384-59-5 5479530 5361919
8
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
10
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
11
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
12
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
13
leucovorin Approved, Nutraceutical Phase 4,Phase 3 58-05-9 54575, 6560146 143
14
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
15 Analgesics Phase 4,Phase 3,Phase 2
16 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Sodium Channel Blockers Phase 4
18 Gentamicins Phase 4,Phase 2,Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
21 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
22 Diuretics, Potassium Sparing Phase 4
23 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
24 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
25 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
26 Immunoglobulins Phase 4,Phase 3,Phase 2
27 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Anticonvulsants Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
30 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1
32 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
33 Antibodies Phase 4,Phase 3,Phase 2
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2
35 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
37 penicillins Phase 4
38
Lactitol Phase 4,Phase 3,Phase 2 585-86-4 3871
39 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
40 glucocorticoids Phase 4,Phase 2,Phase 3
41
protease inhibitors Phase 4,Phase 2,Phase 3
42 Folic Acid Antagonists Phase 4,Phase 3
43 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
44 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 1
45 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
46 Dexamethasone 21-phosphate Phase 4,Phase 2,Phase 3
47 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4,Phase 3
48 Hormones Phase 4,Phase 2,Phase 3,Phase 1
49 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
50 Vitamin B Complex Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 262)
id Name Status NCT ID Phase
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4
2 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
3 Determination of Gentamicin Dosing in Neonatal Patients Unknown status NCT00198601 Phase 4
4 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4
5 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4
6 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
7 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
8 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
9 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
10 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
11 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
12 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4
13 Persistence of Immunogenicity of MenACWY Conjugate Vaccine 5 Years After Childhood Vaccination, and Immune Response to a Booster Dose Completed NCT01823536 Phase 4
14 Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines Completed NCT01270503 Phase 4
15 Descriptive, Post-marketing, Surveillance Safety Study of Menactra Vaccine Completed NCT00254995 Phase 4
16 Safety and Immunogenicity of Intradermal Versus Subcutaneous Doses of Menomune® Completed NCT00850603 Phase 4
17 Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children Completed NCT01430611 Phase 4
18 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
19 Pertussis and Meningitis C Concomitant Vaccination in Adolescents Completed NCT02526394 Phase 4
20 Safety and Local Tolerability of Prevenar in Indian Children Completed NCT00488800 Phase 4
21 Study of Menactra® in US Adolescents When Administered Concomitantly With Tdap Vaccine Completed NCT00777257 Phase 4
22 Persistence of Antibody Response to N. Meningitidis Group C in Children Completed NCT00316654 Phase 4
23 Kinetics of B Cell Response in Infants Menjugate Vaccination Completed NCT00310700 Phase 4
24 Persistence of Immune Response After Vaccination With MCC Completed NCT00310687 Phase 4
25 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
26 Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age Completed NCT01659996 Phase 4
27 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
28 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
29 Persistence of Antibodies and Kinetics of B Cell Response in Healthy Children After Vaccination With MCC Vaccine Completed NCT00310713 Phase 4
30 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Recruiting NCT02864927 Phase 4
31 Ciprofloxacin for the Prevention of Meningococcal Meningitis Active, not recruiting NCT02724046 Phase 4
32 A Trial Comparing Two Pertussis-containing Vaccines in Pregnancy and Vaccine Responses in UK Mothers and Their Infants Active, not recruiting NCT02145624 Phase 4
33 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4
34 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Not yet recruiting NCT03087890 Phase 4
35 An Open Label Field Study of Anthim (Obiltoxaximab) in Subjects Exposed to B. Anthracis Not yet recruiting NCT03088111 Phase 4
36 An Open Label, Phase IV Study Evaluating the Clinical Benefit, Safety and Pharmacokinetics of Raxibacumab in Subjects Exposed to Bacillus Anthracis Not yet recruiting NCT02177721 Phase 4
37 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Not yet recruiting NCT02686853 Phase 4
38 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
39 Amikacin Penetration Into the Cerebrospinal Fluid Withdrawn NCT00362245 Phase 4
40 Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children Unknown status NCT01619462 Phase 3
41 TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial Unknown status NCT02060006 Phase 3
42 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3
43 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
44 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Completed NCT01547715 Phase 3
45 Safety and Immunogenicity Study of MenC-TT Vaccine (NeisVac-C) in Toddlers Previously Immunized With PCV7 (Prevenar®) Completed NCT00617760 Phase 3
46 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
47 A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India Completed NCT01086969 Phase 3
48 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3
49 Comparison of Two Meningococcal ACWY Conjugate Vaccines Completed NCT01192997 Phase 2, Phase 3
50 A Phase 3b Study to Assess the Safety of Novartis Meningococcal B Recombinant Vaccine When Administered in Healthy At-risk Adults Completed NCT01478347 Phase 3

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

39
Brain, Testes, Pituitary, Myeloid, Neutrophil, T Cells, Pineal

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 725)
id Title Authors Year
1
An L-2-Hydroxyglutaric Aciduria Case Presented With Acute Bacterial Meningitis. ( 28141777 )
2017
2
Community-acquired bacterial meningitis. ( 27828810 )
2017
3
Bacterial meningitis in alcoholic patients: A population-based prospective study. ( 28065808 )
2017
4
Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. ( 28049382 )
2017
5
Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. ( 28077083 )
2017
6
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
7
Investigation of the Selection and Timing of Pharmacological Therapy in Community-Acquired Bacterial Meningitis. ( 27408520 )
2016
8
Neisseria meningitidis and Streptococcus pneumoniae as leading causes of pediatric bacterial meningitis in nine Mexican hospitals following 3 years of active surveillance. ( 27551428 )
2016
9
Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein. ( 26986770 )
2016
10
Prognostic Modeling of Bacterial Meningitis: The Search for More Precision. ( 27927862 )
2016
11
Fulminant bacterial meningitis due to Neisseria meningitidis with no pleocytosis on lumbar puncture. ( 27567424 )
2016
12
Community-acquired bacterial meningitis. ( 27808261 )
2016
13
Association between Toll-like receptor 9 gene polymorphisms and risk of bacterial meningitis in a Chinese population. ( 27525854 )
2016
14
Following the (Clinical Decision) Rules: Opportunities for Improving Safety and Resource Utilization With the Bacterial Meningitis Score. ( 27056987 )
2016
15
Synthetic MR Imaging in the Diagnosis of Bacterial Meningitis. ( 28003620 )
2016
16
Cerebrospinal fluid cytokines in the diagnosis of bacterial meningitis in infants. ( 27486702 )
2016
17
A singular case of cavernous internal carotid artery aneurysm in patient with cavernous sinus syndrome and bacterial meningitis. ( 27594955 )
2016
18
Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis. ( 27057100 )
2016
19
Nationwide Trends in Bacterial Meningitis before the Introduction of 13-Valent Pneumococcal Conjugate Vaccine-Burkina Faso, 2011-2013. ( 27832151 )
2016
20
Bacterial meningitis in diabetes patients: a population-based prospective study. ( 27845429 )
2016
21
Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study. ( 27613024 )
2016
22
Clinical and pathogenic analysis of 507 children with bacterial meningitis in Beijing, 2010-2014. ( 27452172 )
2016
23
The diagnostic value of cerebrospinal fluid lactate for post-neurosurgical bacterial meningitis: a meta-analysis. ( 27618955 )
2016
24
Impact of an evidence-based guideline on the management of community-acquired bacterial meningitis: a prospective cohort study. ( 27484018 )
2016
25
Insights into seasonal dynamics of bacterial meningitis. ( 27198826 )
2016
26
Adjunctive dexamethasone therapy in unconfirmed bacterial meningitis in resource limited settings: is it a risk worth taking? ( 27561331 )
2016
27
Community-acquired bacterial meningitis. ( 27808260 )
2016
28
Bacterial meningitis in hematopoietic stem cell transplant recipients: a population-based prospective study. ( 27376451 )
2016
29
Bacterial meningitis in a patient with multiple sclerosis receiving Tysabri. ( 27648180 )
2016
30
A proposal for a new score-based approach to improve the efficiency of diagnostic laboratory workflow for acute bacterial meningitis in adults. ( 27170017 )
2016
31
Seasonal dynamics of bacterial meningitis: a time-series analysis. ( 27198841 )
2016
32
Zoonotic bacterial meningitis in human adults. ( 27534710 )
2016
33
Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study. ( 27816734 )
2016
34
Erratum: A case of Cefepime encephalopathy, being difficult to distinguish from non-convulsive status epilepticus during the treatment of bacterial meningitis. ( 27904066 )
2016
35
Clinical, Paraclinical, and Antimicrobial Resistance Features of Community-Acquired Acute Bacterial Meningitis at a Large Infectious Diseases Ward in Tehran, Iran. ( 27610176 )
2016
36
Fluid therapy for acute bacterial meningitis. ( 27813057 )
2016
37
Comment on the letter to the editor concerning manuscript: "Therapeutic hypothermia for adult community-acquired bacterial meningitis-historical control study". ( 27005446 )
2016
38
Time to antibiotic therapy and outcome in bacterial meningitis: a Danish population-based cohort study. ( 27507415 )
2016
39
Validation of the bacterial meningitis score in adults presenting to the ED with meningitis. ( 27139257 )
2016
40
Spontaneous Escherichia coli bacterial meningitis mimicking heatstroke in an adult. ( 27099718 )
2016
41
Bacteriologic Methods in the diagnosis of Acute Bacterial Meningitis. ( 27567647 )
2016
42
Outcomes of bacterial meningitis in children. ( 27020729 )
2016
43
Neonatal bacterial meningitis in Tikur Anbessa Specialized Hospital, Ethiopia: a 10-year retrospective review. ( 27917346 )
2016
44
Neurological sequelae of bacterial meningitis. ( 27105658 )
2016
45
Corticosteroid dosage for acute bacterial meningitis in children. ( 27184877 )
2016
46
Risk scores for outcome in bacterial meningitis: Systematic review and external validation study. ( 27519619 )
2016
47
Clinical Value of Assessing Cytokine Levels for the Differential Diagnosis of Bacterial Meningitis in a Pediatric Population. ( 27043692 )
2016
48
Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis. ( 26986140 )
2016
49
Usefulness of procalcitonin level as an outcome predictor of adult bacterial meningitis. ( 27460950 )
2016
50
ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. ( 27062097 )
2016

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CFP CRP CXCL1 CXCL8 IL10 IL1B
2
Show member pathways
13.42 CXCL1 CXCL8 IL10 IL1B TLR2 TLR4
3
Show member pathways
13.01 CXCL1 CXCL8 IL1B TLR2 TLR4 TLR9
4
Show member pathways
12.89 CXCL8 IL10 IL1B MMP9 TLR2 TLR4
5
Show member pathways
12.81 CFP CXCL8 IL1B TLR2 TLR4 TLR9
6
Show member pathways
12.7 IL1B TLR2 TLR4 TLR9 TNF
7
Show member pathways
12.62 IL1B TLR2 TLR4 TLR9 TNF
8
Show member pathways
12.61 IL10 IL1B TLR2 TLR4 TNF
9 12.57 IL10 IL1B TLR2 TLR9 TNF
10
Show member pathways
12.33 ALB CRP IL1B TNF
11
Show member pathways
12.33 CXCL1 CXCL8 IL1B MMP9 TLR2 TNF
12 12.3 MMP9 TLR2 TLR4 TNF
13
Show member pathways
12.3 CXCL8 TLR2 TLR4 TLR9 TNF
14
Show member pathways
12.29 IL10 IL1B TLR2 TLR4 TNF
15
Show member pathways
12.28 CXCL8 IL1B TLR4 TNF
16 12.21 MMP9 TLR2 TLR4 TLR9 TNF
17 12.21 IL10 IL1B TLR2 TLR4 TLR9 TNF
18 12.2 CXCL8 IL10 IL1B TNF
19
Show member pathways
12.18 CXCL8 IL10 IL1B TNF
20
Show member pathways
12.13 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
21
Show member pathways
12.06 IL1B TLR2 TLR4 TLR9
22 12.02 CXCL8 IL10 IL1B MMP9 TNF
23 12 CXCL1 IL1B MMP9 TNF
24
Show member pathways
11.96 IL1B TLR2 TLR4 TLR9
25 11.93 CXCL8 IL1B TLR4 TNF
26 11.92 CXCL1 CXCL8 IL1B MMP9 TLR4 TNF
27 11.91 CXCL1 CXCL8 IL1B
28 11.88 CXCL8 IL1B TNF
29
Show member pathways
11.88 MMP8 MMP9 TNF
30 11.88 CXCL1 CXCL8 IL1B TLR4
31
Show member pathways
11.85 CXCL1 CXCL8 TLR4
32
Show member pathways
11.83 IL10 IL1B TLR2 TLR4 TLR9 TNF
33 11.82 IL10 IL1B TLR9 TNF
34 11.81 TLR2 TLR4 TLR9
35 11.78 IL10 IL1B TNF
36 11.77 CXCL8 IL10 IL1B TLR4 TNF
37 11.71 CXCL8 IL1B MMP9 TNF
38
Show member pathways
11.71 CXCL8 IL1B MMP9 TNF
39 11.7 IL10 TLR2 TLR4 TLR9 TNF
40 11.69 CXCL1 CXCL8 IL1B TLR2 TLR4 TNF
41 11.57 IL1B TLR2 TLR4 TNF
42 11.49 CXCL1 CXCL8 IL10 IL1B TNF
43 11.48 CXCL1 CXCL8 IL10 IL1B TLR2 TLR4
44 11.4 IL10 IL1B TLR9 TNF
45 11.39 IL10 IL1B TLR4 TNF
46 11.37 CXCL1 CXCL8 IL1B TLR2 TLR4 TNF
47 11.31 CXCL1 IL10 IL1B TNF
48 11.25 CXCL1 CXCL8 IL10 IL1B TNF
49 11.23 IL1B MMP9 TLR2
50 11.1 CRP CXCL8 TNF

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CFP CRP CXCL1 CXCL8 IL10
2 extracellular space GO:0005615 9.47 ALB CFP CKB CRP CXCL1 CXCL8
3 tertiary granule lumen GO:1904724 9.46 CFP CXCL1 MMP8 MMP9
4 specific granule lumen GO:0035580 9.43 CFP CXCL1 MMP8

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 CFP IL10 TLR4 TLR9 TNF
2 positive regulation of gene expression GO:0010628 9.99 CRP IL1B TLR2 TLR4 TLR9 TNF
3 response to lipopolysaccharide GO:0032496 9.97 CXCL1 IL10 IL1B TLR2 TLR4
4 immune response GO:0006955 9.97 CFP CXCL1 CXCL8 IL10 IL1B TLR2
5 cellular response to lipopolysaccharide GO:0071222 9.92 CXCL8 IL10 TLR4 TNF
6 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
7 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.89 IL10 IL1B TNF
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B S100B TLR4 TLR9 TNF
9 response to glucocorticoid GO:0051384 9.88 IL10 S100B TNF
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B TLR2 TLR4 TLR9 TNF
11 defense response to Gram-positive bacterium GO:0050830 9.87 CRP TLR2 TNF
12 positive regulation of JNK cascade GO:0046330 9.86 IL1B TLR4 TLR9 TNF
13 positive regulation of inflammatory response GO:0050729 9.85 TLR2 TLR4 TLR9
14 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR2 TLR4 TLR9
15 toll-like receptor signaling pathway GO:0002224 9.83 TLR2 TLR4 TLR9
16 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 IL1B TLR4 TNF
18 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.8 TLR2 TLR4 TLR9
19 positive regulation of interferon-beta production GO:0032728 9.79 TLR2 TLR4 TLR9
20 positive regulation of interleukin-12 production GO:0032735 9.78 TLR2 TLR4 TLR9
21 positive regulation of interleukin-10 production GO:0032733 9.77 TLR2 TLR4 TLR9
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 IL10 MMP9 TNF
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 IL1B TLR2 TLR4 TNF
24 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.74 TLR2 TLR4 TLR9
25 negative regulation of interleukin-6 production GO:0032715 9.73 IL10 TLR4 TLR9 TNF
26 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
29 I-kappaB phosphorylation GO:0007252 9.72 TLR2 TLR4 TLR9
30 positive regulation of chemokine biosynthetic process GO:0045080 9.71 IL1B TNF
31 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
32 negative regulation of lipid storage GO:0010888 9.71 CRP TNF
33 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
34 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
35 positive regulation of chemokine production GO:0032722 9.71 TLR2 TLR4 TLR9 TNF
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR4 TNF
37 regulation of cytokine secretion GO:0050707 9.7 TLR2 TLR4 TLR9
38 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IL10 TLR4
40 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
41 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR4 TLR9
42 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
43 negative regulation of interleukin-8 production GO:0032717 9.67 IL10 TLR9
44 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
45 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
46 positive regulation of toll-like receptor signaling pathway GO:0034123 9.65 TLR2 TLR9
47 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TLR2 TLR4 TLR9 TNF
48 receptor biosynthetic process GO:0032800 9.64 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 IL1B TNF
50 positive regulation of interleukin-18 production GO:0032741 9.62 TLR2 TLR9

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL1 CXCL8 IL10 IL1B TNF
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Bacterial Meningitis

3 CDC
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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68 Tocris
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70 UMLS via Orphanet
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