MCID: BCT007
MIFTS: 53

Bacterial Meningitis

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 50 3 14
Meningitis, Bacterial 50 42 69
Meningitis Bacterial 52

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD10 33 G00 G00.9
ICD9CM 35 320 320.9
MeSH 42 D016920
NCIt 47 C118297
UMLS 69 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Español: Meningitis bacteriana

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to aseptic meningitis and sinusitis. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and liver, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
id Related Disease Score Top Affiliating Genes
1 aseptic meningitis 30.6 TLR2 TLR4 TNF
2 sinusitis 30.4 CXCL8 IL1B TNF
3 systemic lupus erythematosus 28.9 ALB CRP IL10 TLR9 TNF
4 malaria 27.0 ALB CRP CXCL8 IL10 IL1B MMP9
5 meningitis 11.6
6 haemophilus meningitis 11.4
7 pure autonomic failure 10.9 IL10 TNF
8 acute ackee fruit intoxication 10.9 IL10 TNF
9 tabatznik syndrome 10.8 IL1B TNF
10 cerebral palsy 10.8
11 meningococcal meningitis 10.8
12 sternal cleft 10.8 IL1B TNF
13 oculomotor nerve paralysis 10.7 CXCL8 IL1B
14 mycobacterium malmoense 10.7 CXCL8 TLR2
15 multiple familial trichoepithelioma 10.7 IL10 TNF
16 common peroneal nerve lesion 10.7 CXCL8 IL1B
17 lagophthalmos 10.7 IL10 TNF
18 early-onset zonular cataract 10.7 IL10 IL1B TNF
19 toxic optic neuropathy 10.7 IL1B MMP9
20 noma 10.7 IL10 IL1B TNF
21 high pressure neurological syndrome 10.7 IL10 IL1B TNF
22 basidiobolomycosis 10.7 CXCL8 IL10 TNF
23 benign neonatal seizures 10.7 CRP IL1B TNF
24 neutrophil-specific granule deficiency 10.7 IL10 TLR2
25 pulmonary hypertension 10.7 IL1B TNF
26 familial mediterranean fever, ad 10.7 CRP IL1B TNF
27 amyotrophic lateral sclerosis type 10 10.7 CXCL8 IL1B TNF
28 epulis 10.7 CXCL8 IL1B TNF
29 tarsal tunnel syndrome 10.7 CXCL8 IL10 TNF
30 patau syndrome 10.7 CRP IL1B TNF
31 tularemia 10.7 IL10 TLR9 TNF
32 plantar wart 10.7 CXCL8 IL10 TNF
33 infancy electroclinical syndrome 10.7 CXCL8 IL10 IL1B
34 brucella canis brucellosis 10.7 IL1B TLR9 TNF
35 residual stage corticosteroid-induced glaucoma 10.7 CRP IL10 TNF
36 acquired thrombocytopenia 10.7 CXCL8 IL1B TNF
37 type 1 papillary adenoma of the kidney 10.7 IL10 TNF
38 peroneal nerve paralysis 10.7 IL10 TLR9
39 pancreas lymphoma 10.7 CRP IL1B TNF
40 cicatricial lagophthalmos 10.6 CRP CXCL8 TNF
41 dysphagia 10.6 CXCL8 IL10 TNF
42 motor peripheral neuropathy 10.6 IL10 TLR9 TNF
43 early congenital syphilis 10.6 CRP TLR9 TNF
44 tibialis tendinitis 10.6 CXCL8 IL1B TNF
45 sublingual gland cancer 10.6 IL10 TLR9 TNF
46 hidradenitis 10.6 CRP CXCL8 IL1B
47 whistling face syndrome, recessive form 10.6 CRP CXCL8 IL1B
48 halal setton wang syndrome 10.6 CXCL8 TLR2 TNF
49 hypospadias 10.6 IL10 TLR2 TNF
50 louping ill 10.6 CRP CXCL8 TNF

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CRP PIK3C2A IL10 PTGDS S100B IL1B
2 immune system MP:0005387 10.1 CRP PIK3C2A IL10 PTGDS IL1B TLR2
3 cardiovascular system MP:0005385 10.09 CFP CRP PIK3C2A IL10 IL1B TLR2
4 digestive/alimentary MP:0005381 9.95 MMP9 IL10 TLR2 ALB TLR4 TLR9
5 mortality/aging MP:0010768 9.9 CFP MMP9 PIK3C2A PTGDS IL10 IL1B
6 integument MP:0010771 9.86 IL10 PTGDS S100B IL1B TLR2 MMP9
7 neoplasm MP:0002006 9.61 IL10 PTGDS IL1B TLR2 MMP8 ALB
8 skeleton MP:0005390 9.23 CFP MMP9 PTGDS IL10 IL1B TLR2

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
3
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
4
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
5
Ceftriaxone Approved Phase 4,Phase 3,Phase 1 73384-59-5 5479530 5361919
6
Azathioprine Approved Phase 4 446-86-6 2265
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
8
Sulfamethoxazole Approved Phase 4 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
10
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
13 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
15 Anticonvulsants Phase 4
16 Diuretics, Potassium Sparing Phase 4
17 Sodium Channel Blockers Phase 4
18 Antibodies Phase 4,Phase 2,Phase 3
19 Immunoglobulins Phase 4,Phase 2,Phase 3
20 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
22 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Analgesics Phase 4,Phase 3,Phase 2
24 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
25 Antipyretics Phase 4,Phase 3,Phase 2
26 beta-Lactams Phase 4
27 Lactams Phase 4
28 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
29 Gentamicins Phase 4,Phase 3
30 penicillins Phase 4,Phase 3
31 Antimetabolites Phase 4
32 Antimetabolites, Antineoplastic Phase 4
33 Antirheumatic Agents Phase 4,Phase 2
34 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
35 Immunosuppressive Agents Phase 4
36 Antiparasitic Agents Phase 4,Phase 3,Phase 2
37 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
38 Vitamin B Complex Phase 4,Phase 2,Phase 3
39 Topoisomerase Inhibitors Phase 4,Phase 2,Phase 1
40 Antiemetics Phase 4,Phase 2,Phase 3
41 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
42 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
43 Autonomic Agents Phase 4,Phase 2,Phase 3
44 BB 1101 Phase 4,Phase 2,Phase 3
45 Dexamethasone acetate Phase 4,Phase 2,Phase 3 1177-87-3
46 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
47 glucocorticoids Phase 4,Phase 2,Phase 3
48 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
49 Hormone Antagonists Phase 4,Phase 2,Phase 3
50 Hormones Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 153)

id Name Status NCT ID Phase Drugs
1 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
3 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
4 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
5 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
6 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
7 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
8 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
9 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
10 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
11 Pharmacological Study of High Doses of Ceftriaxone in Meningitidis Completed NCT01745679 Phase 4 Ceftriaxone treatment
12 Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria Recruiting NCT03087890 Phase 4 Cotrimoxazole;Placebo
13 Ciprofloxacin for the Prevention of Meningococcal Meningitis Active, not recruiting NCT02724046 Phase 4 Ciprofloxacin
14 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Active, not recruiting NCT02864927 Phase 4
15 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Not yet recruiting NCT02588196 Phase 4 Dexamethasone acetate
16 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
17 Amikacin Penetration Into the Cerebrospinal Fluid Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
18 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
19 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
20 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Completed NCT01547715 Phase 3
21 Safety and Immunogenicity Study of MenC-TT Vaccine (NeisVac-C) in Toddlers Previously Immunized With PCV7 (Prevenar®) Completed NCT00617760 Phase 3
22 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
23 DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants Completed NCT02274285 Phase 3
24 A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India Completed NCT01086969 Phase 3
25 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
26 Comparison of Two Meningococcal ACWY Conjugate Vaccines Completed NCT01192997 Phase 2, Phase 3
27 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Infants Completed NCT00474526 Phase 3
28 Evaluation of Persistence of Anti-meningococcal Bactericidal Antibodies Among Adolescents Who Previously Received MenACWY Conjugate Vaccine Completed NCT00856297 Phase 3
29 Evaluation of Meningococcal Immune Response Among Children Who Previously Received MenACWY Conjugate Vaccine Completed NCT01148017 Phase 3
30 Safety and Immunogenicity Evaluation After One or Two Doses of Novartis Meningococcal ACWY Conjugate Vaccine in Healthy Infants and Toddlers Completed NCT00667602 Phase 3
31 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years Completed NCT01352793 Phase 3
32 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults 56 Years and Older Completed NCT02842866 Phase 3
33 Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02842853 Phase 3
34 Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02752906 Phase 3
35 Safety and Blood Donations in Adults Vaccinated With rMenB+OMV NZ. Completed NCT02305446 Phase 3
36 Immunogenicity, Safety and Lot to Lot Consistency of Novartis Meningococcal B Recombinant Vaccine When Administered With Routine Infant Vaccinations to Healthy Infants Completed NCT00657709 Phase 3
37 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Vaccine In Healthy Adults Completed NCT00474487 Phase 3
38 A Study to Evaluate Safety and Immune Response of Novartis Meningococcal ACWY Conjugate Vaccine In US Adolescents and Adults Completed NCT00450437 Phase 3
39 Antibody Persistence, and Safety and Tolerability of a Booster Dose of the Meningococcal B Vaccine After the Completion of the Vaccination Course in Study V72_28 Completed NCT01894919 Phase 3
40 A Phase 3b Study to Assess the Safety of Novartis Meningococcal B Recombinant Vaccine When Administered in Healthy At-risk Adults Completed NCT01478347 Phase 3
41 Study of NeisVac-C Vaccine to Evaluate Immunological Interference With Hepatitis B, Inactivated Polio and Acellular Pertussis Vaccines in Healthy Infants Completed NCT00161928 Phase 3
42 Immunogenicity and Safety of the Concomitant Administration of a Tdap Vaccine and Meningococcal ACWY Conjugate Vaccine in Healthy Subjects Aged 11-25 Years Completed NCT00329901 Phase 3
43 Safety and Immunogenicity of Novartis Meningococcal B Vaccine Formulated With OMV Manufactured at Two Different Sites, in Healthy Adolescents Aged 11-17 Years Completed NCT01423084 Phase 3
44 Safety and Immunogenicity of 2 or 3 Doses of MenACWY Conjugate Vaccine in Healthy Infants and the Effects of a Booster Dose of MenACWY Administered in the Second Year of Life Completed NCT01214837 Phase 3
45 Safety, Tolerability and Immunogenicity of Meningococcal B Recombinant Vaccine Administered as Booster Dose at 12, 18 or 24 Months of Age in Toddlers (12-24 Months) Primed With a Three-Dose Immunization Series as Infants in Study V72P12 Completed NCT00944034 Phase 2, Phase 3
46 Study of a Single Dose of Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects Completed NCT01519713 Phase 3
47 A Multi-center, Observer-blind, Placebo-controlled, Randomized Study to Evaluate the Immunogenicity and Safety of MenACWY in Adolescents and Adults in Korea Completed NCT01274897 Phase 3
48 Persistence of Antibody Levels and Response to Fifth or Third Meningococcal B Recombinant Vaccine in 4-year Old Healthy Children Who Previously Participated in Study V72P12E1 Completed NCT01717638 Phase 3
49 A Phase 3B, Open Label, Multi-Center Study to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered Alone to Healthy Infants According to Different Immunization Schedules and to Healthy Chil Completed NCT01339923 Phase 3
50 Assessment of Antibody Persistence at Eighteen Months After the Completion of the Vaccination Course in Study V72P10 Completed NCT01148524 Phase 2, Phase 3

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

39
Testes, Brain, Liver, Pituitary, Myeloid, Neutrophil, T Cells

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 745)
id Title Authors Year
1
Changes in the incidence of pneumonia, bacterial meningitis, and infant mortality 5 years following introduction of the 13-valent pneumococcal conjugate vaccine in a "3+0" schedule. ( 28813518 )
2017
2
Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention. ( 28925647 )
2017
3
Evaluation of the line probe assay for the rapid detection of bacterial meningitis pathogens in cerebrospinal fluid samples from children. ( 28077083 )
2017
4
Intraventricular administration of tigecycline for the treatment of multidrug-resistant bacterial meningitis after craniotomy: a case report. ( 28614982 )
2017
5
An Unexpected Cause of Bradycardia in a Patient with Bacterial Meningitis. ( 28713431 )
2017
6
Bacterial meningitis in alcoholic patients: A population-based prospective study. ( 28065808 )
2017
7
Comparison of enterovirus detection in cerebrospinal fluid with Bacterial Meningitis Score in children. ( 28767914 )
2017
8
Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. ( 28049382 )
2017
9
Pituitary Apoplexy Mimicking Bacterial Meningitis with Intracranial Hypertension. ( 27756666 )
2017
10
Recurrent CSF Rhinorrhea Misdiagnosed as Chronic Allergic Rhinitis with Subsequent Development of Bacterial Meningitis. ( 28819362 )
2017
11
Community-acquired bacterial meningitis. ( 27828810 )
2017
12
Rapid detection of bacterial meningitis using a point-of-care glucometer. ( 28799985 )
2017
13
Cerebrospinal Fluid Rhinorrhea and Subsequent Bacterial Meningitis due to an Atypical Clival Fracture. ( 28717092 )
2017
14
Evaluation of bacterial meningitis surveillance data of the northern region, Ghana, 2010-2015. ( 28904692 )
2017
15
Bacterial meningitis complicating the course of liver cirrhosis. ( 28616745 )
2017
16
Prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in Yunnan province, China, 2012-2015. ( 28662145 )
2017
17
CRAMP deficiency leads to a pro-inflammatory phenotype and impaired phagocytosis after exposure to bacterial meningitis pathogens. ( 28915816 )
2017
18
Early versus late diagnosis in community-acquired bacterial meningitis: a retrospective cohort study. ( 28652113 )
2017
19
Assessment of healthcare delivery in the early management of bacterial meningitis in UK young infants: an observational study. ( 28827241 )
2017
20
Cerebrospinal Fluid Cathelicidin Correlates with the Bacterial Load and Outcomes in Childhood Bacterial Meningitis. ( 28827496 )
2017
21
Frequency of acute bacterial meningitis in children with first episode of febrile seizures. ( 28770886 )
2017
22
Acute Bacterial Meningitis in Qatar: A Hospital-Based Study from 2009 to 2013. ( 28785577 )
2017
23
Emergency Medicine Myths: Computed Tomography of the Head PriorA to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice? ( 28666562 )
2017
24
An L-2-Hydroxyglutaric Aciduria Case Presented With Acute Bacterial Meningitis. ( 28141777 )
2017
25
Bacterial meningitis due to Streptococcus pneumoniae following untreated idiopathic hypertrophic pachymeningitis. ( 28870586 )
2017
26
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
27
Predicting Outcome of Childhood Bacterial Meningitis With a Single Measurement of C-Reactive Protein. ( 26986770 )
2016
28
Clinical and pathogenic analysis of 507 children with bacterial meningitis in Beijing, 2010-2014. ( 27452172 )
2016
29
Association between Toll-like receptor 9 gene polymorphisms and risk of bacterial meningitis in a Chinese population. ( 27525854 )
2016
30
Swiftly Decreasing Cerebrospinal Fluid Cathelicidin Concentration Predicts Improved Outcome in Childhood Bacterial Meningitis. ( 27008883 )
2016
31
The diagnostic value of cerebrospinal fluid lactate for post-neurosurgical bacterial meningitis: a meta-analysis. ( 27618955 )
2016
32
Fulminant bacterial meningitis due to Neisseria meningitidis with no pleocytosis on lumbar puncture. ( 27567424 )
2016
33
A proposal for a new score-based approach to improve the efficiency of diagnostic laboratory workflow for acute bacterial meningitis in adults. ( 27170017 )
2016
34
Childhood Acute Bacterial Meningitis: Clinical Spectrum, Bacteriological Profile and Outcome. ( 27806810 )
2016
35
Investigation of the Selection and Timing of Pharmacological Therapy in Community-Acquired Bacterial Meningitis. ( 27408520 )
2016
36
Role of Rifampin in Reducing Inflammation and Neuronal Damage in Childhood Bacterial Meningitis: A Pilot Randomized Controlled Trial. ( 28027282 )
2016
37
Community-acquired bacterial meningitis. ( 27808261 )
2016
38
Challenges of bacterial meningitis case management in Ethiopia. ( 27145202 )
2016
39
Bacterial Meningitis in Patients using Immunosuppressive Medication: a Population-based Prospective Nationwide Study. ( 27613024 )
2016
40
ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. ( 27062097 )
2016
41
Bacterial meningitis in a patient with multiple sclerosis receiving Tysabri. ( 27648180 )
2016
42
Prediction of Outcome From Adult Bacterial Meningitis in a High-HIV-Seroprevalence, Resource-Poor Setting Using the Malawi Adult Meningitis Score (MAMS). ( 27927860 )
2016
43
Adjunctive dexamethasone therapy in unconfirmed bacterial meningitis in resource limited settings: is it a risk worth taking? ( 27561331 )
2016
44
Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis. ( 26986140 )
2016
45
A ten-year retrospective case series of glucocorticoid treatment of bacterial meningitis in children. ( 27102576 )
2016
46
A singular case of cavernous internal carotid artery aneurysm in patient with cavernous sinus syndrome and bacterial meningitis. ( 27594955 )
2016
47
Clinical, Paraclinical, and Antimicrobial Resistance Features of Community-Acquired Acute Bacterial Meningitis at a Large Infectious Diseases Ward in Tehran, Iran. ( 27610176 )
2016
48
Prognostic Modeling of Bacterial Meningitis: The Search for More Precision. ( 27927862 )
2016
49
Bacteriologic Methods in the diagnosis of Acute Bacterial Meningitis. ( 27567647 )
2016
50
Neuron-Specific Enolase Is Correlated to Compromised Cerebral Metabolism in Patients Suffering from Acute Bacterial Meningitis; An Observational Cohort Study. ( 27019200 )
2016

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show all 48)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CFP CRP CXCL8 IL10 IL1B MMP8
2
Show member pathways
13.37 CXCL8 IL10 IL1B TLR2 TLR4 TLR9
3
Show member pathways
12.98 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
4
Show member pathways
12.83 CXCL8 IL10 IL1B TLR2 TLR4 TLR9
5
Show member pathways
12.79 CFP CXCL8 IL1B TLR2 TLR4 TLR9
6
Show member pathways
12.69 IL1B TLR2 TLR4 TLR9 TNF
7
Show member pathways
12.61 IL1B TLR2 TLR4 TLR9 TNF
8
Show member pathways
12.59 IL10 IL1B TLR2 TLR4 TNF
9 12.55 IL10 IL1B TLR2 TLR9 TNF
10
Show member pathways
12.35 CXCL8 IL1B MMP9 TLR2 TNF
11 12.29 MMP9 TLR2 TLR4 TNF
12
Show member pathways
12.27 IL10 IL1B TLR2 TLR4 TNF
13
Show member pathways
12.26 CXCL8 IL1B TLR4 TNF
14 12.2 MMP9 TLR2 TLR4 TLR9 TNF
15 12.18 CXCL8 IL10 IL1B TNF
16
Show member pathways
12.16 CXCL8 IL10 IL1B TNF
17 12.13 IL10 IL1B TLR2 TLR4 TLR9 TNF
18
Show member pathways
12.06 CXCL8 IL1B TLR2 TLR4 TLR9 TNF
19
Show member pathways
12.04 IL1B PIK3C2A TLR2 TLR4 TLR9
20 12.01 CXCL8 IL1B MMP9 TLR4 TNF
21 11.98 CXCL8 IL10 IL1B MMP9 TNF
22
Show member pathways
11.94 IL1B TLR2 TLR4 TLR9
23 11.92 CXCL8 IL1B TLR4 TNF
24 11.91 IL1B MMP9 TNF
25 11.87 CXCL8 IL1B TNF
26
Show member pathways
11.87 MMP8 MMP9 TNF
27 11.81 CXCL8 IL1B TLR2 TLR4 TNF
28 11.8 CXCL8 IL1B TLR4
29 11.8 TLR2 TLR4 TLR9
30 11.79 IL10 IL1B TLR9 TNF
31 11.77 IL10 IL1B TNF
32 11.71 CXCL8 IL10 IL1B TLR4 TNF
33 11.7 CXCL8 IL1B MMP9 TNF
34
Show member pathways
11.69 CXCL8 IL1B MMP9 TNF
35
Show member pathways
11.66 IL10 IL1B TLR2 TLR4 TLR9 TNF
36 11.57 CXCL8 IL10 IL1B TNF
37 11.56 IL10 TLR2 TLR4 TLR9 TNF
38 11.55 IL1B TLR2 TLR4 TNF
39 11.42 CXCL8 IL10 IL1B TLR2 TLR4 TNF
40 11.4 CXCL8 IL1B TLR2 TLR4 TNF
41 11.34 IL10 IL1B TLR9 TNF
42 11.32 IL10 IL1B TLR4 TNF
43 11.3 IL10 IL1B TNF
44 11.22 IL1B MMP9 TLR2
45 11.21 CXCL8 IL10 IL1B TNF
46 11.08 CRP CXCL8 TNF
47 10.91 IL1B TNF
48 10.86 CXCL8 IL10 IL1B TLR2 TLR4 TLR9

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALB CFP CRP CXCL8 IL10 IL1B
2 extracellular space GO:0005615 9.44 ALB CFP CKB CRP CXCL8 IL10
3 tertiary granule lumen GO:1904724 9.33 CFP MMP8 MMP9

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.98 IL10 IL1B TLR2 TLR4
2 defense response to bacterium GO:0042742 9.97 CFP IL10 TLR4 TLR9 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.92 CXCL8 IL10 TLR4 TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.9 IL10 IL1B TNF
5 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.89 CRP TLR2 TNF
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B S100B TLR4 TLR9 TNF
8 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B TLR2 TLR4 TLR9 TNF
9 response to glucocorticoid GO:0051384 9.87 IL10 S100B TNF
10 positive regulation of JNK cascade GO:0046330 9.87 IL1B TLR4 TLR9 TNF
11 positive regulation of inflammatory response GO:0050729 9.86 TLR2 TLR4 TLR9
12 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR2 TLR4 TLR9
13 toll-like receptor signaling pathway GO:0002224 9.83 TLR2 TLR4 TLR9
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.83 IL1B TLR4 TNF
15 positive regulation of interferon-gamma production GO:0032729 9.83 IL1B TLR4 TNF
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.79 TLR2 TLR4 TLR9
17 positive regulation of interferon-beta production GO:0032728 9.78 TLR2 TLR4 TLR9
18 positive regulation of interleukin-12 production GO:0032735 9.77 TLR2 TLR4 TLR9
19 positive regulation of interleukin-10 production GO:0032733 9.77 TLR2 TLR4 TLR9
20 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.76 IL10 MMP9 TNF
21 inflammatory response GO:0006954 9.76 CRP CXCL8 IL10 IL1B TLR2 TLR4
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.73 TLR2 TLR4 TLR9
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 IL1B TLR2 TLR4 TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
27 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
28 cellular response to lipoteichoic acid GO:0071223 9.71 TLR2 TLR4
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL10 IL1B TNF
30 negative regulation of interleukin-6 production GO:0032715 9.71 IL10 TLR4 TLR9 TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.7 IL1B TNF
32 negative regulation of lipid storage GO:0010888 9.7 CRP TNF
33 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4 TLR9
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
35 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.69 IL10 TLR4
37 regulation of cytokine secretion GO:0050707 9.69 TLR2 TLR4 TLR9
38 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
39 positive regulation of interferon-beta biosynthetic process GO:0045359 9.68 TLR4 TLR9
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 IL10 TNF
41 negative regulation of interleukin-8 production GO:0032717 9.67 IL10 TLR9
42 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
43 positive regulation of chemokine production GO:0032722 9.67 TLR2 TLR4 TLR9 TNF
44 sequestering of triglyceride GO:0030730 9.65 IL1B TNF
45 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TLR2 TLR4 TLR9 TNF
46 positive regulation of interleukin-18 production GO:0032741 9.64 TLR2 TLR9
47 positive regulation of toll-like receptor signaling pathway GO:0034123 9.63 TLR2 TLR9
48 receptor biosynthetic process GO:0032800 9.63 IL10 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
50 response to molecule of bacterial origin GO:0002237 9.62 CXCL8 IL10 TLR2 TLR9

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL10 IL1B TNF
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Bacterial Meningitis

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