MCID: BCT002
MIFTS: 56

Bacterial Vaginosis malady

Summaries for Bacterial Vaginosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bacterial infectious disease that is associated with a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.

MalaCards: Bacterial Vaginosis, also known as nsv - nonspecific vaginitis, is related to candidiasis and vulvovaginal candidiasis. An important gene associated with Bacterial Vaginosis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Senescence and Autophagy and Rheumatoid arthritis. The drugs acetic acid and metronidazole and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and cervix, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:3 Any woman can get BV.

Wikipedia:63 Bacterial vaginosis (BV) or very uncommonly vaginal bacteriosis is a disease of the vagina caused by... more...

Aliases & Classifications for Bacterial Vaginosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

bacterial vaginosis 8 10 44 60
nsv - nonspecific vaginitis 8


External Ids:

Disease Ontology8 DOID:3385
MeSH34 D016585

Related Diseases for Bacterial Vaginosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to bacterial vaginosis

Clinical Features for Bacterial Vaginosis

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Drugs & Therapeutics for Bacterial Vaginosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bacterial Vaginosis

Drug clinical trials:

Search ClinicalTrials for Bacterial Vaginosis

Search NIH Clinical Center for Bacterial Vaginosis

Search CenterWatch for Bacterial Vaginosis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Bacterial Vaginosis

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Anatomical Context for Bacterial Vaginosis

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32MalaCards
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MalaCards organs/tissues related to Bacterial Vaginosis:

32
Testes, Colon, Cervix, T cells

Animal Models for Bacterial Vaginosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bacterial Vaginosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8IL1R1, IL1B, MMP8
2MP:00053979.6IL1A, IL8, IL1R1, LTF, PRF1, NEU1
3MP:00053879.1LAP3, TLR4, MBL2, NEU1, PRF1, LTF

Publications for Bacterial Vaginosis

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50PubMed
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Articles related to Bacterial Vaginosis:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Bacterial Vaginosis and the Risk of Trichomonas vaginalis Acquisition Among HIV-1-Negative Women. (24413493)
2014
2
High-Dose Vaginal Metronidazole for Recurrent Bacterial Vaginosis-A Pilot Study. (23994951)
2013
3
Efficacy of vitamin C vaginal tablets as prophylaxis for recurrent bacterial vaginosis: a randomised, double-blind, placebo-controlled clinical trial. (23864922)
2013
4
Prevalent and incident bacterial vaginosis are associated with sexual and contraceptive behaviours in young Australian women. (23472099)
2013
5
Behavioural and medical predictors of bacterial vaginosis recurrence among female sex workers: longitudinal analysis from a randomized controlled trial. (23657072)
2013
6
Where are we with partner treatment in bacterial vaginosis? A critical appraisal of the latest systematic review. (23677025)
2013
7
Association between aerobic vaginitis, bacterial vaginosis and squamous intraepithelial lesion of low grade. (24341052)
2013
8
Bacterial vaginosis among African American women who have sex with women. (23949590)
2013
9
Development and validation of a semiquantitative, multitarget PCR assay for diagnosis of bacterial vaginosis. (22535982)
2012
10
Bacterial vaginosis is conducive to the persistence of HPV infection. (22930296)
2012
11
Prevalence of bacterial vaginosis and its risk factors in HIV/AIDS patients with abnormal vaginal discharge. (21771443)
2011
12
Association between bacterial vaginosis and preterm delivery. (21240174)
2011
13
The genital econiche: focus on microbiota and bacterial vaginosis. (21824165)
2011
14
Co-occurrence of Trichomonas vaginalis and bacterial vaginosis among HIV-positive women. (20842073)
2011
15
Cervical leukorrhea is correlated with bacterial vaginosis. (21315345)
2011
16
A case control study of anovaginal distance and bacterial vaginosis. (21515758)
2011
17
Bacterial vaginosis in threatened preterm, preterm and term labour. (21344795)
2010
18
Long-term vaginal administration of Lactobacillus rhamnosus as a complementary approach to management of bacterial vaginosis. (20573348)
2010
19
Diagnosis and management of bacterial vaginosis and other types of abnormal vaginal bacterial flora: a review. (20723268)
2010
20
Antagonism and synergism in Gardnerella vaginalis strains isolated from women with bacterial vaginosis. (20466841)
2010
21
Morphological peculiarities of endometrium in chronic endometritis associated with bacterial vaginosis. (20495228)
2010
22
Diagnosis of sexually transmitted infections and bacterial vaginosis among HIV-1-infected pregnant women in Nairobi. (20975086)
2010
23
The epidemiology of bacterial vaginosis in relation to sexual behaviour. (20353563)
2010
24
Interobserver variation in the interpretation of Nugent scoring method for diagnosis of bacterial vaginosis. (20167979)
2010
25
Correlation of Trichomonas vaginalis to bacterial vaginosis: a laboratory-based study. (20351456)
2010
26
Bacterial vaginosis: update on evidence-based care. (20128204)
2010
27
Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (19131402)
2009
28
Bacterial vaginosis: are we coming full circle? (19863440)
2009
29
Prevalence of bacterial vaginosis and impact of genital hygiene practices in non-pregnant women in zanjan, iran. (22216382)
2009
30
New concepts in the etiology of bacterial vaginosis. (19239805)
2009
31
Use of antibiotics in the treatment for bacterial vaginosis. (19451341)
2009
32
The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis. (18823487)
2008
33
Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis. (18336917)
2008
34
TLR2-mediated cell stimulation in bacterial vaginosis. (17532476)
2008
35
Diversity of human vaginal bacterial communities and associations with clinically defined bacterial vaginosis. (18487399)
2008
36
Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery. (18757648)
2008
37
Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. (18614873)
2008
38
The polymicrobial hypothesis of bacterial vaginosis causation: a reassessment. (18397551)
2008
39
Cytokines, pregnancy, and bacterial vaginosis: comparison of levels of cervical cytokines in pregnant and nonpregnant women with bacterial vaginosis. (17922400)
2007
40
Prevalence of bacterial vaginosis in Thai pregnant women with preterm labor in Siriraj hospital. (17427517)
2007
41
Treatment of bacterial vaginosis in pregnancy: a new perspective. (17346481)
2007
42
Vaginal douching and development of bacterial vaginosis among women with normal and abnormal vaginal microflora. (17413534)
2007
43
Natural history of asymptomatic bacterial vaginosis in a high-risk group of women. (17522586)
2007
44
Use of pH/whiff test or QuickVue Advanced pH and Amines test for the diagnosis of bacterial vaginosis and prevention of postabortion pelvic inflammatory disease. (16817083)
2006
45
Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species. (16643824)
2006
46
Bacterial vaginosis and anaerobic bacteria are associated with endometritis. (15472851)
2004
47
Clinical variability of bacterial vaginosis and trichomoniasis. (15568400)
2004
48
The association of intrauterine device usage with bacterial vaginosis in a gynecology outpatient clinic in Ankara, Turkey. (16868405)
2003
49
Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora. (1551983)
1992
50
The prevalence, six-month persistence, and predictive values of laboratory indicators of bacterial vaginosis (nonspecific vaginitis) in asymptomatic women. (6391177)
1984

Genetic Variations for Bacterial Vaginosis

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Expression for genes affiliated with Bacterial Vaginosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for genes affiliated with Bacterial Vaginosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL8
210.3TLR4
310.3TLR4
410.3IL1B, IL1A
510.1IL1B, IL1A, IL8
6
Hide members
10.1IL1R1, IL1A, IL1B
7
Hide members
10.1IL1B, IL1A, IL1R1
810.1IL1B, IL1A, IL1R1
910.1IL1B, IL8, TLR4
10
Hide members
10.1IL1B, IL1R1, TLR4
1110.1TLR4, IL1A, IL1B
1210.1TLR4, IL1R1, IL1A
13
Hide members
10.0TLR4, IL1R1, IL8, IL1B
1410.0TLR4, IL1R1, IL8, IL1B
1510.0TLR4, IL1R1, IL8, IL1B
1610.0IL1B, IL1A, IL8, TLR4
1710.0IL1B, IL1A, IL8, TLR4
18
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
19
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
20
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
21
Hide members
10.0IL1B, IL1A, IL1R1, TLR4
22
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
2310.0IL1B, IL1A, IL1R1, TLR4
2410.0DEFA5, DEFA3, DEFA1
259.9DEFA3, DEFA1, LTF, MMP8
26
Hide members
9.9IL1B, IL1A, IL8, IL1R1, TLR4
27
Hide members
9.9TLR4, IL1R1, IL8, IL1A, IL1B
28
Immune response Bacterial infections in normal airways
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9.8IL1B, IL1A, IL8, IL1R1, DEFB4A, TLR4
29
Hide members
9.7DEFA5, DEFA3, DEFB4A, DEFA1, DEFB104A
30
Hide members
9.2TLR4, MBL2, DEFA5, DEFA3, DEFB4A, DEFA1

Compounds for genes affiliated with Bacterial Vaginosis

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.6IL1R1, LTF
2endotoxin4410.5HPGD, LTF, DEFB4A
3fmlp4410.5IL1A, LTF
4hydrocortisone44 2 59 1113.5CRHBP, LTF, IL8
5monosodium urate4410.5IL1R1, IL1B, IL8
6muramyl dipeptide44 2811.5IL8, IL1B, TLR4
7tenidap44 2811.4IL1R1, IL1A, IL1B, LTF
8gold sodium thiomalate4410.4IL1A, IL8, IL1B, IL1R1
9sulfasalazine44 28 49 1113.4IL1R1, IL8, IL1A, IL1B
10flagellin44 2811.4IL1B, IL8, DEFB4A, TLR4
11pneumococcal4410.4LTF, NEU1, TLR4
12polyinosinic-polycytidylic acid4410.4IL1B, TLR4, IL8, IL1A
134-ipp5910.3IL1R1, IL1A, IL1B
14nacl4410.3DEFA1, IL1R1, LTF, DEFB4A
15diphenyleneiodonium4410.3IL1B, IL1R1, TLR4, IL8
16git 275910.3IL1R1, IL1A, IL1B
17il 104410.3IL1A, TLR4, IL1R1, IL8, IL1B
18ccl344 2811.3IL1R1, IL1A, IL8, TLR4, IL1B
19h2o24410.3MMP8, IL1R1, LAP3, LTF, NEU1
20polymyxin b4410.3TLR4, IL1B, IL1A, IL8, LTF, MBL2
21neopterin4410.2MBL2, IL8, IL1B, IL1A, IL1R1, LTF
22lipoteichoic acid4410.2MBL2, TLR4, DEFB4A, IL1R1, IL8, IL1B
23peptidoglycan44 2811.2TLR4, MBL2, IL8, DEFB4A, IL1B, IL1R1
24rantes4410.2IL1A, IL1B, DEFB4A, TLR4, MBL2, IL1R1
25cyclosporin a44 28 5912.2MMP8, IL1R1, LTF
26mannose4410.2DEFB4A, LTF, NEU1, TLR4, MBL2
27phosphatidylcholine4410.2NEU1, MBL2, LTF, PRF1
28estrogen4410.1LTF, PEPD, CRHBP, MBL2, DEFB4A
29sb 20358044 5911.1TLR4, IL1A, IL1B, IL8, IL1R1, DEFB4A
30hyaluronic acid44 2411.1IL1A, IL8, IL1B, PEPD, LTF, NEU1
31pirfenidone44 5911.1IL1B, IL1A, IL1R1
32histamine44 28 2412.1IL1B, DEFB4A, LTF, TLR4, IL8, NEU1
33anti-fungal4410.1TLR4, MBL2, DEFA3, LTF, DEFA1, DEFB4A
34pdtc4410.1IL1B, IL8, TLR4, IL1A
35actinomycin d4410.1IL8, IL1A, LTF, IL1B, IL1R1, TLR4
36prostaglandin4410.1IL1R1, IL1A, IL1B, HPGD, CRHBP
37as 10159 4411.0IL1B, IL1R1, IL1A
38superoxide44 2411.0MBL2, LTF, IL8, IL1B, MMP8, PEPD
39hbd24410.0IL8, TLR4, DEFA5, DEFA3, DEFB4A, DEFA1
40genistein44 28 59 2 11 2415.0TLR4, IL1A, DEFB4A, IL8, MMP8, IL1B
41progesterone44 59 28 11 2413.9MBL2, CRHBP, HPGD, IL1R1, IL1A, MMP8
42leukotriene b444 59 2411.9IL8, IL1B, LAP3, RNPEP, IL1A, IL1R1
43serine449.9MMP8, HPGD, TLR4, NEU1, LTF, PEPD
44vegf449.8LAP3, MMP8, IL1B, IL8, IL1R1, LTF
45creatinine449.8IL1A, IL1R1, LTF, LAP3, MBL2, PEPD
46alanine449.8MMP8, RNPEP, IL1R1, TLR4, HPGD, LTF
47retinoic acid44 2410.8IL1A, IL1R1, LTF, DEFB4A, TLR4, LAP3
48cysteine449.7MMP8, IL8, IL1R1, HPGD, LAP3, DEFB4A
49dexamethasone44 49 28 1112.7IL1R1, IL8, LTF, DEFB4A, IL1B, IL1A
50nitric oxide44 11 2411.4IL1R1, TLR4, IL1B, MBL2, IL1A, MMP8

GO Terms for genes affiliated with Bacterial Vaginosis

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16Gene Ontology
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Cellular components related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0DEFB4A, DEFA3, DEFA5
2secretory granuleGO:0301419.8CRHBP, LTF, IL1B
3extracellular spaceGO:0056159.2MBL2, CRHBP, DEFA5, DEFA3, RNPEP, IL8
4extracellular regionGO:0055769.0MMP8, MBL2, PRF1, DEFA5, DEFA3, DEFB4A

Biological processes related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.4IL1B, IL1A
2killing of cells of other organismGO:03164010.2DEFA3, DEFA5
3positive regulation of interleukin-2 biosynthetic processGO:04508610.2IL1B, IL1A
4immune responseGO:0069559.9TLR4, DEFB4A, IL1R1, IL8, IL1A, IL1B
5defense response to bacteriumGO:0427429.9LTF, DEFB4A, DEFA3, DEFA5, MBL2, TLR4
6proteolysisGO:0065089.9LTF, RNPEP, MMP8, LAP3, PEPD
7innate immune responseGO:0450879.8DEFB4A, DEFA3, DEFA5, MBL2, TLR4
8inflammatory responseGO:0069549.7CRHBP, IL8, IL1A, IL1B

Molecular functions related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1A
2aminopeptidase activityGO:00417710.0PEPD, LAP3, RNPEP
3metalloexopeptidase activityGO:0082359.9LAP3, RNPEP

Products for genes affiliated with Bacterial Vaginosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacterial Vaginosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet