MCID: BCT002
MIFTS: 56

Bacterial Vaginosis malady

Summaries for Bacterial Vaginosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bacterial infectious disease that is associated with a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.

MalaCards: Bacterial Vaginosis, also known as nsv - nonspecific vaginitis, is related to candidiasis and vulvovaginal candidiasis. An important gene associated with Bacterial Vaginosis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Senescence and Autophagy and Rheumatoid arthritis. The drugs metronidazole and metronidazole hydrochloride and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and cervix, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:3 Any woman can get BV.

Wikipedia:63 Bacterial vaginosis (BV) or very uncommonly vaginal bacteriosis is a disease of the vagina caused by... more...

Aliases & Classifications for Bacterial Vaginosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

bacterial vaginosis 8 10 44 60
nsv - nonspecific vaginitis 8


External Ids:

Disease Ontology8 DOID:3385
MeSH34 D016585

Related Diseases for Bacterial Vaginosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to bacterial vaginosis

Clinical Features for Bacterial Vaginosis

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Drugs & Therapeutics for Bacterial Vaginosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bacterial Vaginosis

Drug clinical trials:

Search ClinicalTrials for Bacterial Vaginosis

Search NIH Clinical Center for Bacterial Vaginosis

Search CenterWatch for Bacterial Vaginosis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Bacterial Vaginosis

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Anatomical Context for Bacterial Vaginosis

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32MalaCards
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MalaCards organs/tissues related to Bacterial Vaginosis:

32
Testes, Colon, Cervix, T cells

Animal Models for Bacterial Vaginosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bacterial Vaginosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8IL1R1, IL1B, MMP8
2MP:00053979.6IL1A, IL8, IL1R1, LTF, PRF1, NEU1
3MP:00053879.1LAP3, TLR4, MBL2, NEU1, PRF1, LTF

Publications for Bacterial Vaginosis

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50PubMed
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Articles related to Bacterial Vaginosis:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Prevalence of Gardnerella vaginalis and Atopobium vaginae in Portuguese women and association with risk factors for bacterial vaginosis. (24268352)
2014
2
The burden of bacterial vaginosis: women's experience of the physical, emotional, sexual and social impact of living with recurrent bacterial vaginosis. (24040236)
2013
3
Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis. (23543384)
2013
4
Bacterial vaginosis-associated bacteria in men: association of Leptotrichia/Sneathia spp. with nongonococcal urethritis. (24220356)
2013
5
Evaluation of vaginal pH for detection of bacterial vaginosis. (24135180)
2013
6
The role of vaginal Lactobacillus Rhamnosus (NormoginAr) in preventing Bacterial Vaginosis in women with history of recurrences, undergoing surgical menopause: a prospective pilot study. (23740456)
2013
7
Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota. (22585228)
2012
8
Safety and efficacy of an intravaginal prebiotic gel in the prevention of recurrent bacterial vaginosis: a randomized double-blind study. (23316237)
2012
9
Genetic and biochemical diversity of Gardnerella vaginalis strains isolated from women with bacterial vaginosis. (22309200)
2012
10
Hydrolysis of secreted sialoglycoprotein immunoglobulin A (IgA) in ex vivo and biochemical models of bacterial vaginosis. (22134918)
2012
11
Extended antimicrobial treatment of bacterial vaginosis combined with human lactobacilli to find the best treatment and minimize the risk of relapses. (21854593)
2011
12
Bacterial vaginosis: what is physiological in vaginal bacteriology? An update and opinion. (21916857)
2011
13
Bacterial vaginosis: Etiology and modalities of treatment-A brief note. (22219582)
2011
14
Discussion: 'Bacterial vaginosis and STI risk' by Allsworth et al. (22088840)
2011
15
Use of a lactic acid plus lactoserum intimate liquid soap for external hygiene in the prevention of bacterial vaginosis recurrence after metronidazole oral treatment. (21876923)
2011
16
A behavioural intervention to reduce persistence of bacterial vaginosis among women who report sex with women: results of a randomised trial. (21653935)
2011
17
Bacterial vaginosis and preterm birth. (22060217)
2011
18
Risks for acquisition of bacterial vaginosis among women who report sex with women: a cohort study. (20559445)
2010
19
Metabolic properties of lactobacilli in women experiencing recurring episodes of bacterial vaginosis with vaginal pH >or= 5. (19802749)
2010
20
Personal hygienic behaviors and bacterial vaginosis. (19823112)
2010
21
Treatment of bacterial vaginosis: a multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole. (20885970)
2010
22
Factors associated with recurrent bacterial vaginosis. (20337209)
2010
23
Do bacterial vaginosis and chlamydial infection affect serum cytokine level? (20842889)
2010
24
Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis. (19274321)
2008
25
Prevalence of Candida albicans and bacterial vaginosis in asymptomatic pregnant women in South Yorkshire, United Kingdom. Outcome of a prospective study. (18299865)
2008
26
Cutting edge: the vaginal microflora and bacterial vaginosis. (18669158)
2008
27
A comparative study of the therapeutic effects of the Zataria multiflora vaginal cream and metronidazole vaginal gel on bacterial vaginosis. (18824338)
2008
28
Local profile of cytokines and nitric oxide in patients with bacterial vaginosis and cervical intraepithelial neoplasia. (17683845)
2008
29
Comparison of the diversity of the vaginal microbiota in HIV-infected and HIV-uninfected women with or without bacterial vaginosis. (18717638)
2008
30
Relative performance of three methods for diagnosing bacterial vaginosis during pregnancy. (17874288)
2007
31
Psychological and biological markers of stress and bacterial vaginosis in pregnant women. (17305894)
2007
32
Genital tract interleukin-8 but not interleukin-1beta or interleukin-6 concentration is associated with bacterial vaginosis and its clearance in HIV-infected and HIV-uninfected women. (18273408)
2007
33
Intermittent intravaginal antibiotic treatment of bacterial vaginosis in HIV-uninfected and -infected women: a randomized clinical trial. (17318258)
2007
34
Nutrition, an under-recognized factor in bacterial vaginosis. (17709432)
2007
35
Vaginal symptoms and bacterial vaginosis (BV): how useful is self-report? Development of a screening tool for predicting BV status. (17274857)
2007
36
Dynamics of vaginal bacterial communities in women developing bacterial vaginosis, candidiasis, or no infection, analyzed by PCR-denaturing gradient gel electrophoresis and real-time PCR. (17644631)
2007
37
Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix? (16604551)
2006
38
The effects of intravaginal clindamycin and metronidazole therapy on vaginal lactobacilli in patients with bacterial vaginosis. (16647910)
2006
39
High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. (16652274)
2006
40
Risk factors for bacterial vaginosis in pregnancy: a population-based study on Danish women. (16862466)
2006
41
Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. (16697231)
2006
42
A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth. (15284722)
2004
43
Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. (12616147)
2003
44
Evaluation of a fast test to identify the presence of proline aminopeptidase in women with bacterial vaginosis. (18476142)
1997
45
Screening for bacterial vaginosis and cervicitis aimed at preventing premature delivery. (9094827)
1997
46
Pilot study to evaluate the appropriate management of patients with coexistent bacterial vaginosis and cervicitis. (18476033)
1995
47
Vaginitis including bacterial vaginosis. (7742505)
1994
48
Allergic vaginitis mimicking bacterial vaginosis. (1965569)
1990
49
Association between bacterial vaginosis and acute cystitis in women using diaphragms. (2673116)
1989
50
In vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid. (3141171)
1988

Genetic Variations for Bacterial Vaginosis

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Expression for genes affiliated with Bacterial Vaginosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for genes affiliated with Bacterial Vaginosis

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37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL8
210.3TLR4
310.3TLR4
410.3IL1B, IL1A
510.1IL1B, IL1A, IL8
6
Hide members
10.1IL1R1, IL1A, IL1B
7
Hide members
10.1IL1B, IL1A, IL1R1
810.1IL1B, IL1A, IL1R1
910.1IL1B, IL8, TLR4
10
Hide members
10.1IL1B, IL1R1, TLR4
1110.1TLR4, IL1A, IL1B
1210.1TLR4, IL1R1, IL1A
13
Hide members
10.0TLR4, IL1R1, IL8, IL1B
1410.0TLR4, IL1R1, IL8, IL1B
1510.0TLR4, IL1R1, IL8, IL1B
1610.0IL1B, IL1A, IL8, TLR4
1710.0IL1B, IL1A, IL8, TLR4
18
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
19
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
20
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
21
Hide members
10.0IL1B, IL1A, IL1R1, TLR4
22
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
2310.0IL1B, IL1A, IL1R1, TLR4
2410.0DEFA5, DEFA3, DEFA1
259.9DEFA3, DEFA1, LTF, MMP8
26
Hide members
9.9IL1B, IL1A, IL8, IL1R1, TLR4
27
Hide members
9.9TLR4, IL1R1, IL8, IL1A, IL1B
28
Immune response Bacterial infections in normal airways
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9.8IL1B, IL1A, IL8, IL1R1, DEFB4A, TLR4
29
Hide members
9.7DEFA5, DEFA3, DEFB4A, DEFA1, DEFB104A
30
Hide members
9.2TLR4, MBL2, DEFA5, DEFA3, DEFB4A, DEFA1

Compounds for genes affiliated with Bacterial Vaginosis

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.6IL1R1, LTF
2endotoxin4410.5HPGD, LTF, DEFB4A
3fmlp4410.5IL1A, LTF
4hydrocortisone44 2 59 1113.5CRHBP, LTF, IL8
5monosodium urate4410.5IL1R1, IL1B, IL8
6muramyl dipeptide44 2811.5IL8, IL1B, TLR4
7tenidap44 2811.4IL1R1, IL1A, IL1B, LTF
8gold sodium thiomalate4410.4IL1A, IL8, IL1B, IL1R1
9sulfasalazine44 28 49 1113.4IL1R1, IL8, IL1A, IL1B
10flagellin44 2811.4IL1B, IL8, DEFB4A, TLR4
11pneumococcal4410.4LTF, NEU1, TLR4
12polyinosinic-polycytidylic acid4410.4IL1B, TLR4, IL8, IL1A
134-ipp5910.3IL1R1, IL1A, IL1B
14nacl4410.3DEFA1, IL1R1, LTF, DEFB4A
15diphenyleneiodonium4410.3IL1B, IL1R1, TLR4, IL8
16git 275910.3IL1R1, IL1A, IL1B
17il 104410.3IL1A, TLR4, IL1R1, IL8, IL1B
18ccl344 2811.3IL1R1, IL1A, IL8, TLR4, IL1B
19h2o24410.3MMP8, IL1R1, LAP3, LTF, NEU1
20polymyxin b4410.3TLR4, IL1B, IL1A, IL8, LTF, MBL2
21neopterin4410.2MBL2, IL8, IL1B, IL1A, IL1R1, LTF
22lipoteichoic acid4410.2MBL2, TLR4, DEFB4A, IL1R1, IL8, IL1B
23peptidoglycan44 2811.2TLR4, MBL2, IL8, DEFB4A, IL1B, IL1R1
24rantes4410.2IL1A, IL1B, DEFB4A, TLR4, MBL2, IL1R1
25cyclosporin a44 28 5912.2MMP8, IL1R1, LTF
26mannose4410.2DEFB4A, LTF, NEU1, TLR4, MBL2
27phosphatidylcholine4410.2NEU1, MBL2, LTF, PRF1
28estrogen4410.1LTF, PEPD, CRHBP, MBL2, DEFB4A
29sb 20358044 5911.1TLR4, IL1A, IL1B, IL8, IL1R1, DEFB4A
30hyaluronic acid44 2411.1IL1A, IL8, IL1B, PEPD, LTF, NEU1
31pirfenidone44 5911.1IL1B, IL1A, IL1R1
32histamine44 28 2412.1IL1B, DEFB4A, LTF, TLR4, IL8, NEU1
33anti-fungal4410.1TLR4, MBL2, DEFA3, LTF, DEFA1, DEFB4A
34pdtc4410.1IL1B, IL8, TLR4, IL1A
35actinomycin d4410.1IL8, IL1A, LTF, IL1B, IL1R1, TLR4
36prostaglandin4410.1IL1R1, IL1A, IL1B, HPGD, CRHBP
37as 10159 4411.0IL1B, IL1R1, IL1A
38superoxide44 2411.0MBL2, LTF, IL8, IL1B, MMP8, PEPD
39hbd24410.0IL8, TLR4, DEFA5, DEFA3, DEFB4A, DEFA1
40genistein44 28 59 2 11 2415.0TLR4, IL1A, DEFB4A, IL8, MMP8, IL1B
41progesterone44 59 28 11 2413.9MBL2, CRHBP, HPGD, IL1R1, IL1A, MMP8
42leukotriene b444 59 2411.9IL8, IL1B, LAP3, RNPEP, IL1A, IL1R1
43serine449.9MMP8, HPGD, TLR4, NEU1, LTF, PEPD
44vegf449.8LAP3, MMP8, IL1B, IL8, IL1R1, LTF
45creatinine449.8IL1A, IL1R1, LTF, LAP3, MBL2, PEPD
46alanine449.8MMP8, RNPEP, IL1R1, TLR4, HPGD, LTF
47retinoic acid44 2410.8IL1A, IL1R1, LTF, DEFB4A, TLR4, LAP3
48cysteine449.7MMP8, IL8, IL1R1, HPGD, LAP3, DEFB4A
49dexamethasone44 49 28 1112.7IL1R1, IL8, LTF, DEFB4A, IL1B, IL1A
50nitric oxide44 11 2411.4IL1R1, TLR4, IL1B, MBL2, IL1A, MMP8

GO Terms for genes affiliated with Bacterial Vaginosis

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16Gene Ontology
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Cellular components related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0DEFB4A, DEFA3, DEFA5
2secretory granuleGO:0301419.8CRHBP, LTF, IL1B
3extracellular spaceGO:0056159.2MBL2, CRHBP, DEFA5, DEFA3, RNPEP, IL8
4extracellular regionGO:0055769.0MMP8, MBL2, PRF1, DEFA5, DEFA3, DEFB4A

Biological processes related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.4IL1B, IL1A
2killing of cells of other organismGO:03164010.2DEFA3, DEFA5
3positive regulation of interleukin-2 biosynthetic processGO:04508610.2IL1B, IL1A
4immune responseGO:0069559.9TLR4, DEFB4A, IL1R1, IL8, IL1A, IL1B
5defense response to bacteriumGO:0427429.9LTF, DEFB4A, DEFA3, DEFA5, MBL2, TLR4
6proteolysisGO:0065089.9LTF, RNPEP, MMP8, LAP3, PEPD
7innate immune responseGO:0450879.8DEFB4A, DEFA3, DEFA5, MBL2, TLR4
8inflammatory responseGO:0069549.7CRHBP, IL8, IL1A, IL1B

Molecular functions related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1A
2aminopeptidase activityGO:00417710.0PEPD, LAP3, RNPEP
3metalloexopeptidase activityGO:0082359.9LAP3, RNPEP

Products for genes affiliated with Bacterial Vaginosis

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  • Antibodies
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  • Antibodies

Sources for Bacterial Vaginosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet