MCID: BCT002
MIFTS: 52

Bacterial Vaginosis malady

Reproductive diseases category

Summaries for Bacterial Vaginosis

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9Disease Ontology, 4CDC, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.

MalaCards: Bacterial Vaginosis, also known as nsv - nonspecific vaginitis, is related to periodontitis and periodontal disease. An important gene associated with Bacterial Vaginosis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are MAPK Pathway and Hematopoietic cell lineage. The drugs metronidazole and metronidazole hydrochloride and the compounds monosaccharide and tenidap have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and cervix, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

CDC:4 Any woman can get BV.

Wikipedia:66 Bacterial vaginosis (BV) or very uncommonly vaginal bacteriosis is a disease of the vagina caused by... more...

Aliases & Classifications for Bacterial Vaginosis

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

bacterial vaginosis 9 11 46 63
nsv - nonspecific vaginitis 9


External Ids:

Disease Ontology9 DOID:3385
MeSH36 D016585

Related Diseases for Bacterial Vaginosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Bacterial Vaginosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1periodontitis30.7IL8, IL1B
2periodontal disease30.6IL1B, IL8
3chorioamnionitis30.1IL1B, IL1R1, IL8
4arthritis30.1IL8, IL1B, IL1R1
5cystic fibrosis30.1PEPD, IL1R1, MBL2, IL8
6vaginitis11.2
7cervicitis10.8
8candidiasis10.8
9trichomoniasis10.7
10blindness10.7
11vulvovaginitis10.7
12vulvovaginal candidiasis10.6
13endometritis10.6
14vaginal discharge10.6
15pelvic inflammatory disease10.5
16hiv-110.5
17herpes simplex10.4
18infertility10.4
19leukorrhea10.4
20cervical intraepithelial neoplasia10.4
21urethritis10.3
22gonorrhea10.3
23reactive arthritis10.1
24chancroid10.1
25endocervicitis10.1
26acute cystitis10.1
27cellulitis10.1
28cystitis10.1
29lichen sclerosus10.1
30pregnancy loss10.1
31hiv/aids10.1
32malaria10.1NEU1
33endophthalmitis10.1PRF1
34endocarditis10.1PRF1
35common cold10.1IL8
36skin disease10.1IL1B, PRF1
37neisseria meningitidis infection10.1MBL2, IL1R1
38muckle-wells syndrome10.0IL1R1, IL1B
39familial cold autoinflammatory syndrome10.0IL1B, IL1R1
40chronic infantile neurological cutaneous articular syndrome10.0IL1R1, IL1B
41otitis media10.0MBL2, IL1B
42shigellosis10.0IL1B, IL1R1
43cerebral malaria10.0IL1B, IL1R1
44vasculitis10.0PEPD, MBL2
45bronchiectasis10.0MBL2, IL8
46iga glomerulonephritis10.0MBL2, IL1R1, NEU1
47hypersensitivity reaction type ii disease10.0PRF1, IL1B
48behcet's disease10.0MBL2, IL8
49interstitial lung disease10.0IL8, IL1R1
50bacterial meningitis10.0IL8, IL1B

Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to bacterial vaginosis

Symptoms for Bacterial Vaginosis

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Drugs & Therapeutics for Bacterial Vaginosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Bacterial Vaginosis

Drug clinical trials:

Search ClinicalTrials for Bacterial Vaginosis

Search NIH Clinical Center for Bacterial Vaginosis

Search CenterWatch for Bacterial Vaginosis

Inferred drug relations via UMLS63/NDF-RT42:

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Genetic Tests for Bacterial Vaginosis

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Anatomical Context for Bacterial Vaginosis

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34MalaCards
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MalaCards organs/tissues related to Bacterial Vaginosis:

34
Testes, Colon, Cervix, T cells

Animal Models for Bacterial Vaginosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Bacterial Vaginosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.1NEU1, PRF1, IL1R1, IL1B, MBL2
2MP:00053977.2NEU1, PRF1, IL1R1, IL8, IL1B, MBL2
3MP:00053877.0NEU1, PRF1, IL1R1, IL8, IL1B, MBL2

Publications for Bacterial Vaginosis

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Sources:
53PubMed
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Articles related to Bacterial Vaginosis:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Prevalence of Gardnerella vaginalis and Atopobium vaginae in Portuguese women and association with risk factors for bacterial vaginosis. (24268352)
2014
2
Strong association between the prevalence of bacterial vaginosis and male point-concurrency. (24183351)
2014
3
Does bacterial vaginosis cause pelvic inflammatory disease? (23324974)
2013
4
Influence of anaerobic conditions on vaginal microbiota recovery from bacterial vaginosis patients. (23687135)
2013
5
Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment. (23798671)
2013
6
The restoration of the vaginal microbiota after treatment for bacterial vaginosis with metronidazole or probiotics. (23250116)
2013
7
Bacterial vaginosis: risks and treatment. (24121846)
2013
8
The natural antimicrobial peptide subtilosin acts synergistically with glycerol monolaurate, lauric arginate, and I/-poly-L-lysine against bacterial vaginosis-associated pathogens but not human lactobacilli. (22252803)
2012
9
Bacterial vaginosis associated with increased risk of female-to-male HIV-1 transmission: a prospective cohort analysis among African couples. (22745608)
2012
10
Influence of early self-diagnosis and treatment of bacterial vaginosis on preterm birth rate. (22445423)
2012
11
Clinical importance of detection of bacterial vaginosis, trichomonas vaginalis, candida albicans and actinomyces in Papanicolaou smears. (23157037)
2012
12
Efficacy of rifaximin vaginal tablets in treatment of bacterial vaginosis: a molecular characterization of the vaginal microbiota. (22585228)
2012
13
Protocol for the use of PCR-denaturing gradient gel electrophoresis and quantitative PCR to determine vaginal microflora constitution and pathogens in bacterial vaginosis. (22782818)
2012
14
Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. (21223574)
2011
15
Low incidence of bacterial vaginosis in cohort of young Australian women. (20739909)
2011
16
Maternal vitamin A and I^-carotene supplementation and risk of bacterial vaginosis: a randomized controlled trial in rural Bangladesh. (22071710)
2011
17
Prevalence of bacterial vaginosis and its risk factors in HIV/AIDS patients with abnormal vaginal discharge. (21771443)
2011
18
Association between bacterial vaginosis and preterm delivery. (21240174)
2011
19
Severity of bacterial vaginosis and the risk of sexually transmitted infection. (21514555)
2011
20
Elucidation of the Molecular Mechanisms of Action of the Natural Antimicrobial Peptide Subtilosin Against the Bacterial Vaginosis-associated Pathogen Gardnerella vaginalis. (21949544)
2011
21
High sialidase levels increase preterm birth risk among women who are bacterial vaginosis-positive in early gestation. (21055720)
2011
22
The genital econiche: focus on microbiota and bacterial vaginosis. (21824165)
2011
23
Bacterial vaginosis in threatened preterm, preterm and term labour. (21344795)
2010
24
How important are the newly described bacteria in bacterial vaginosis? (19625293)
2009
25
Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. (19285652)
2009
26
Bacterial vaginosis. (19750853)
2009
27
Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (19131402)
2009
28
Bacterial vaginosis: are we coming full circle? (19863440)
2009
29
Predictive value for preterm birth of abnormal vaginal flora, bacterial vaginosis and aerobic vaginitis during the first trimester of pregnancy. (19538417)
2009
30
Association of urinary tract infection in women with bacterial vaginosis. (20300409)
2009
31
The efficacy of retreatment with the same medication for early treatment failure of bacterial vaginosis. (19652628)
2009
32
Effect of clindamycin treatment on vaginal inflammatory markers in pregnant women with bacterial vaginosis and a positive fetal fibronectin test. (19647824)
2009
33
Effect of treatment of asymptomatic bacterial vaginosis on HIV-1 shedding in the genital tract among women on antiretroviral therapy: a pilot study. (19694541)
2009
34
Characteristics and pregnancy outcomes of pregnant women asymptomatic for bacterial vaginosis. (17546484)
2008
35
Evidence on the benefits and harms of screening and treating pregnant women who are asymptomatic for bacterial vaginosis: an update review for the U.S. Preventive Services Task Force. (18252684)
2008
36
Prevalence of vulvovaginitis and bacterial vaginosis in patients with koilocytosis. (19274321)
2008
37
The role of Lactobacillus casei rhamnosus Lcr35 in restoring the normal vaginal flora after antibiotic treatment of bacterial vaginosis. (18823487)
2008
38
Predisposing factors for bacterial vaginosis, treatment efficacy and pregnancy outcome among term deliveries; results from a preterm delivery study. (17953762)
2007
39
Asymptomatic bacterial vaginosis: is it time to treat? (17547871)
2007
40
The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. (17621244)
2007
41
Changes in the diagnosis and management of bacterial vaginosis following clinical research. (17044224)
2006
42
Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis. (16872847)
2006
43
Is bacterial vaginosis associated with squamous intraepithelial lesion of the uterine cervix? (16604551)
2006
44
Review: vaginal signs and symptoms perform poorly in diagnosing vaginal candidiasis, bacterial vaginosis, and vaginal trichomoniasis. (15341467)
2004
45
Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. (12529421)
2003
46
Correlation of local interleukin-1beta levels with specific IgA response against Gardnerella vaginalis cytolysin in women with bacterial vaginosis. (12148539)
2002
47
Leukorrhea and bacterial vaginosis as in-office predictors of cervical infection in high-risk women. (12383553)
2002
48
Evaluation of a fast test to identify the presence of proline aminopeptidase in women with bacterial vaginosis. (18476142)
1997
49
Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis. (8946639)
1996
50
Allergic vaginitis mimicking bacterial vaginosis. (1965569)
1990

Variations for Bacterial Vaginosis

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Expression for genes affiliated with Bacterial Vaginosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for genes affiliated with Bacterial Vaginosis

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Sources:
51PathCards, 62Tocris Bioscience, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 55R&D Systems, 13EMD Millipore, 54QIAGEN
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Pathways related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3IL1R1, IL1B
29.3IL1R1, IL1B
3
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.3IL1B, IL1R1
4
Show member pathways
Serotonin Transporter Activity39
9.3IL1B, IL1R1
5
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.3IL1B, IL1R1
6
Show member pathways
9.3IL1B, IL1R1
7
Show member pathways
9.0IL1B, IL8
89.0IL1B, IL8
99.0IL8, IL1B
109.0IL1B, IL8
119.0IL8, IL1B
129.0IL1B, IL8
139.0IL1B, IL8
148.5IL1B, IL8, IL1R1
15
Show member pathways
8.5IL8, IL1B, IL1R1
16
Show member pathways
8.5IL8, IL1R1, IL1B
17
Show member pathways
Immune response MIF in innate immunity response61
8.5IL1B, IL8, IL1R1
188.5IL1R1, IL8, IL1B
19
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.5IL8, IL1B, IL1R1
208.5IL1B, IL8, IL1R1
21
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.5IL1B, IL8, IL1R1
22
Show member pathways
8.5IL1B, IL8, IL1R1

Compounds for genes affiliated with Bacterial Vaginosis

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1monosaccharide469.8MBL2, NEU1
2tenidap46 3010.7IL1B, IL1R1
3anakinra46 1210.7IL1B, IL1R1
4git 27629.6IL1B, IL1R1
54-ipp629.6IL1B, IL1R1
6phosphatidylcholine469.5NEU1, PRF1, MBL2
7pirfenidone46 6210.4IL1R1, IL1B
8bis(2-chloroethyl)sulfide469.4IL8, IL1B
9survanta469.4IL8, IL1B
10echinacea469.4IL8, IL1B
11tlck469.4IL1B, IL8
12as 10146 6210.4IL1R1, IL1B
13lxa4469.4IL8, IL1B
14muramyl dipeptide46 3010.4IL1B, IL8
15taurine chloramine469.4IL8, IL1B
16prednisolone46 30 1211.4PEPD, MBL2, IL1R1
17nacl469.3IL1R1, PRF1, MBL2
18hbd2469.3IL1B, IL8
19toxin-1469.3IL8, IL1B
20mip 1alpha469.3IL1B, IL8
21flagellin46 3010.0IL1B, IL8
22staurosporin469.0IL1B, IL8
23polymyxin b469.0IL1B, MBL2, IL8
24aspirin46 52 30 2512.0PEPD, IL1B, IL1R1
25monosodium urate469.0IL8, IL1B, IL1R1
26gold sodium thiomalate468.9IL1R1, IL1B, IL8
27il-12468.9IL1R1, IL8, IL1B
28sulfasalazine30 46 52 1211.9IL8, IL1R1, IL1B
295 aminosalicylic acid468.9IL8, IL1B
30etanercept46 52 1210.9IL1R1, IL8, IL1B
31il 10468.9IL1B, IL1R1, IL8
32diphenyleneiodonium468.9IL8, IL1R1, IL1B
33pentoxifylline46 129.9IL8, IL1R1, IL1B
34ccl346 309.9IL1R1, IL1B, IL8
35mifepristone46 30 62 1211.9IL1R1, IL8, IL1B
36leukotriene b446 62 2510.9IL1R1, IL8, IL1B
37hydrocortisone46 3 62 1211.9IL8, IL1B, IL1R1
38endotoxin468.8IL8, IL1R1, IL1B
39lipoteichoic acid468.5MBL2, IL8, IL1R1, IL1B
40peptidoglycan46 309.5MBL2, IL1B, IL1R1, IL8
41neopterin468.5IL1B, MBL2, IL1R1, IL8
42rantes468.5IL8, MBL2, IL1B, IL1R1
43dexamethasone46 52 30 1211.4IL1R1, IL8, IL1B, MBL2
44vegf468.3IL1R1, MBL2, IL8, IL1B
45nitric oxide46 25 1210.2MBL2, IL8, IL1R1, IL1B
46n acetylcysteine468.2IL1B, IL1R1, IL8
47cycloheximide468.2IL1R1, PRF1, NEU1, IL8, IL1B
48superoxide46 259.1PEPD, PRF1, IL8, IL1B, MBL2
49hyaluronic acid46 259.0IL1B, PEPD, NEU1, IL1R1, IL8
50serine467.8PRF1, IL8, IL1R1, MBL2, NEU1, PEPD

GO Terms for genes affiliated with Bacterial Vaginosis

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Sources:
17Gene Ontology
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Cellular components related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7MBL2, IL1B, IL8, IL1R1, PRF1

Biological processes related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neutrophil chemotaxisGO:0305939.0IL1B, IL8
2immune responseGO:0069558.2IL1B, IL8, IL1R1

Products for genes affiliated with Bacterial Vaginosis

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  • Antibodies
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  • Antibodies

Sources for Bacterial Vaginosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet