MCID: BCT002
MIFTS: 56

Bacterial Vaginosis malady

Summaries for Bacterial Vaginosis

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bacterial infectious disease that is associated with a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.

MalaCards: Bacterial Vaginosis, also known as nsv - nonspecific vaginitis, is related to candidiasis and vulvovaginal candidiasis. An important gene associated with Bacterial Vaginosis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Senescence and Autophagy and Rheumatoid arthritis. The drugs acetic acid and metronidazole and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and cervix, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:3 Any woman can get BV.

Wikipedia:63 Bacterial vaginosis (BV) or very uncommonly vaginal bacteriosis is a disease of the vagina caused by... more...

Aliases & Classifications for Bacterial Vaginosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

bacterial vaginosis 8 10 44 60
nsv - nonspecific vaginitis 8


External Ids:

Disease Ontology8 DOID:3385
MeSH34 D016585

Related Diseases for Bacterial Vaginosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to bacterial vaginosis

Clinical Features for Bacterial Vaginosis

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Drugs & Therapeutics for Bacterial Vaginosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bacterial Vaginosis

Drug clinical trials:

Search ClinicalTrials for Bacterial Vaginosis

Search NIH Clinical Center for Bacterial Vaginosis

Search CenterWatch for Bacterial Vaginosis

Inferred drug relations via UMLS60/NDF-RT40:

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Genetic Tests for Bacterial Vaginosis

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Anatomical Context for Bacterial Vaginosis

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32MalaCards
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MalaCards organs/tissues related to Bacterial Vaginosis:

32
Testes, Colon, Cervix, T cells

Animal Models for Bacterial Vaginosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bacterial Vaginosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8IL1R1, IL1B, MMP8
2MP:00053979.6IL1A, IL8, IL1R1, LTF, PRF1, NEU1
3MP:00053879.1LAP3, TLR4, MBL2, NEU1, PRF1, LTF

Publications for Bacterial Vaginosis

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50PubMed
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Articles related to Bacterial Vaginosis:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Strong association between the prevalence of bacterial vaginosis and male point-concurrency. (24183351)
2014
2
The restoration of the vaginal microbiota after treatment for bacterial vaginosis with metronidazole or probiotics. (23250116)
2013
3
Bacterial vaginosis: a review on clinical trials with probiotics. (23912864)
2013
4
The global epidemiology of bacterial vaginosis: a systematic review. (23659989)
2013
5
Bacterial vaginosis update. (23943971)
2013
6
The posttrial effect of oral periodic presumptive treatment for vaginal infections on the incidence of bacterial vaginosis and Lactobacillus colonization. (22504600)
2012
7
The interaction effect of bacterial vaginosis and periodontal disease on the risk of preterm delivery. (22105437)
2012
8
Characteristics of Lactobacillus and Gardnerella vaginalis from women with or without bacterial vaginosis and their relationships in gnotobiotic mice. (22539000)
2012
9
Prevalence and risk factors of bacterial vaginosis during the first trimester of pregnancy in a large French population-based study. (22572215)
2012
10
Identification and characterization of bacterial vaginosis-associated pathogens using a comprehensive cervical-vaginal epithelial coculture assay. (23166828)
2012
11
How can the treatment of bacterial vaginosis be improved to reduce the risk of preterm delivery? (22934721)
2012
12
Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid. (21854137)
2012
13
Evaluation of Cytokines in Endocervical Secretion and Vaginal pH from Women with Bacterial Vaginosis or Human Papillomavirus. (22550593)
2012
14
Evidence for Gardnerella vaginalis uptake and internalization by squamous vaginal epithelial cells: implications for the pathogenesis of bacterial vaginosis. (22227318)
2012
15
Topical penile microbicide use by men to prevent recurrent bacterial vaginosis in sex partners: a randomized clinical trial. (22256334)
2011
16
Chapter 2-6-2. Anaerobic infections (individual fields): bacterial vaginosis. (21728101)
2011
17
The aetiology of bacterial vaginosis. (21332897)
2011
18
Effects of bacterial vaginosis-associated bacteria and sexual intercourse on vaginal colonization with the probiotic Lactobacillus crispatus CTV-05. (21992977)
2011
19
Evidence of African-American women's frustrations with chronic recurrent bacterial vaginosis. (20132368)
2010
20
In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women. (19925874)
2010
21
High prevalence of bacterial vaginosis in adolescent girls in a tropical area of Ecuador. (19874295)
2010
22
Bacterial vaginosis. (19750853)
2009
23
The efficacy of retreatment with the same medication for early treatment failure of bacterial vaginosis. (19652628)
2009
24
Bacterial vaginosis - More questions than answers. (19521581)
2009
25
Bacterial vaginosis: an update on diagnosis and treatment. (19883331)
2009
26
Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. (19144794)
2009
27
Bacterial vaginosis with special reference to anaerobes. (19136782)
2009
28
Probiotics for the treatment of bacterial vaginosis. (19821358)
2009
29
Screening for bacterial vaginosis in pregnancy to prevent preterm delivery. (19405414)
2009
30
Bacterial vaginosis: a problematic infection from both a perinatal and neonatal perspective. (19362525)
2009
31
A delicate balance: risk factors for acquisition of bacterial vaginosis include sexual activity, absence of hydrogen peroxide-producing lactobacilli, black race, and positive herpes simplex virus type 2 serology. (17989585)
2008
32
The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy. (18548397)
2008
33
Paternal race and bacterial vaginosis during the first trimester of pregnancy. (18226622)
2008
34
Benefits of Affirm VPIII and L-PAP in the diagnosis of bacterial vaginosis]. (18588815)
2008
35
Hormonal contraceptive use modulates the local inflammatory response to bacterial vaginosis. (17911138)
2008
36
Correlation between squamous intraepithelial lesions (SILs) and bacterial vaginosis. (17713100)
2007
37
The Pap smear for detection of bacterial vaginosis. (17466304)
2007
38
Urinary tract infections in pregnant women with bacterial vaginosis. (17464804)
2007
39
Dietary intake of selected nutrients affects bacterial vaginosis in women. (17709453)
2007
40
Treatment options for bacterial vaginosis in patients at high risk of preterm labor and premature rupture of membranes. (18001442)
2007
41
Treatment of bacterial vaginosis in pregnancy. (17568481)
2007
42
Prevalence and risk factors of trichomoniasis, bacterial vaginosis, and candidiasis for married women of child-bearing age in rural Shandong. (17881863)
2007
43
Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis. (16872847)
2006
44
Bacterial vaginosis in women of low socioeconomic status living in slum areas in Chennai, India. (17112444)
2006
45
The association between copper containing IUCD and bacterial vaginosis. (17152227)
2006
46
Clinical characteristics of vaginal discharge in bacterial vaginosis diagnosed by Nugent's criteria. (16761528)
2006
47
BVBLUE test for diagnosis of bacterial vaginosis in pregnant women attending antenatal care at Phramongkutklao Hospital. (16858939)
2005
48
A cluster analysis of bacterial vaginosis-associated microflora and pelvic inflammatory disease. (16093289)
2005
49
The effect of introduction of a guideline on the management of vaginal discharge and in particular bacterial vaginosis in primary care. (11356730)
2001
50
Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis. (8946639)
1996

Genetic Variations for Bacterial Vaginosis

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Expression for genes affiliated with Bacterial Vaginosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for genes affiliated with Bacterial Vaginosis

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 51QIAGEN, 52R&D Systems, 12EMD Millipore, 59Tocris Bioscience
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Pathways related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL8
210.3TLR4
310.3TLR4
410.3IL1B, IL1A
510.1IL1B, IL1A, IL8
6
Hide members
10.1IL1R1, IL1A, IL1B
7
Hide members
10.1IL1B, IL1A, IL1R1
810.1IL1B, IL1A, IL1R1
910.1IL1B, IL8, TLR4
10
Hide members
10.1IL1B, IL1R1, TLR4
1110.1TLR4, IL1A, IL1B
1210.1TLR4, IL1R1, IL1A
13
Hide members
10.0TLR4, IL1R1, IL8, IL1B
1410.0TLR4, IL1R1, IL8, IL1B
1510.0TLR4, IL1R1, IL8, IL1B
1610.0IL1B, IL1A, IL8, TLR4
1710.0IL1B, IL1A, IL8, TLR4
18
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
19
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
20
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
21
Hide members
10.0IL1B, IL1A, IL1R1, TLR4
22
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
2310.0IL1B, IL1A, IL1R1, TLR4
2410.0DEFA5, DEFA3, DEFA1
259.9DEFA3, DEFA1, LTF, MMP8
26
Hide members
9.9IL1B, IL1A, IL8, IL1R1, TLR4
27
Hide members
9.9TLR4, IL1R1, IL8, IL1A, IL1B
28
Immune response Bacterial infections in normal airways
Hide members
9.8IL1B, IL1A, IL8, IL1R1, DEFB4A, TLR4
29
Hide members
9.7DEFA5, DEFA3, DEFB4A, DEFA1, DEFB104A
30
Hide members
9.2TLR4, MBL2, DEFA5, DEFA3, DEFB4A, DEFA1

Compounds for genes affiliated with Bacterial Vaginosis

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1pentoxifylline44 1111.6IL1R1, LTF
2endotoxin4410.5HPGD, LTF, DEFB4A
3fmlp4410.5IL1A, LTF
4hydrocortisone44 2 59 1113.5CRHBP, LTF, IL8
5monosodium urate4410.5IL1R1, IL1B, IL8
6muramyl dipeptide44 2811.5IL8, IL1B, TLR4
7tenidap44 2811.4IL1R1, IL1A, IL1B, LTF
8gold sodium thiomalate4410.4IL1A, IL8, IL1B, IL1R1
9sulfasalazine44 28 49 1113.4IL1R1, IL8, IL1A, IL1B
10flagellin44 2811.4IL1B, IL8, DEFB4A, TLR4
11pneumococcal4410.4LTF, NEU1, TLR4
12polyinosinic-polycytidylic acid4410.4IL1B, TLR4, IL8, IL1A
134-ipp5910.3IL1R1, IL1A, IL1B
14nacl4410.3DEFA1, IL1R1, LTF, DEFB4A
15diphenyleneiodonium4410.3IL1B, IL1R1, TLR4, IL8
16git 275910.3IL1R1, IL1A, IL1B
17il 104410.3IL1A, TLR4, IL1R1, IL8, IL1B
18ccl344 2811.3IL1R1, IL1A, IL8, TLR4, IL1B
19h2o24410.3MMP8, IL1R1, LAP3, LTF, NEU1
20polymyxin b4410.3TLR4, IL1B, IL1A, IL8, LTF, MBL2
21neopterin4410.2MBL2, IL8, IL1B, IL1A, IL1R1, LTF
22lipoteichoic acid4410.2MBL2, TLR4, DEFB4A, IL1R1, IL8, IL1B
23peptidoglycan44 2811.2TLR4, MBL2, IL8, DEFB4A, IL1B, IL1R1
24rantes4410.2IL1A, IL1B, DEFB4A, TLR4, MBL2, IL1R1
25cyclosporin a44 28 5912.2MMP8, IL1R1, LTF
26mannose4410.2DEFB4A, LTF, NEU1, TLR4, MBL2
27phosphatidylcholine4410.2NEU1, MBL2, LTF, PRF1
28estrogen4410.1LTF, PEPD, CRHBP, MBL2, DEFB4A
29sb 20358044 5911.1TLR4, IL1A, IL1B, IL8, IL1R1, DEFB4A
30hyaluronic acid44 2411.1IL1A, IL8, IL1B, PEPD, LTF, NEU1
31pirfenidone44 5911.1IL1B, IL1A, IL1R1
32histamine44 28 2412.1IL1B, DEFB4A, LTF, TLR4, IL8, NEU1
33anti-fungal4410.1TLR4, MBL2, DEFA3, LTF, DEFA1, DEFB4A
34pdtc4410.1IL1B, IL8, TLR4, IL1A
35actinomycin d4410.1IL8, IL1A, LTF, IL1B, IL1R1, TLR4
36prostaglandin4410.1IL1R1, IL1A, IL1B, HPGD, CRHBP
37as 10159 4411.0IL1B, IL1R1, IL1A
38superoxide44 2411.0MBL2, LTF, IL8, IL1B, MMP8, PEPD
39hbd24410.0IL8, TLR4, DEFA5, DEFA3, DEFB4A, DEFA1
40genistein44 28 59 2 11 2415.0TLR4, IL1A, DEFB4A, IL8, MMP8, IL1B
41progesterone44 59 28 11 2413.9MBL2, CRHBP, HPGD, IL1R1, IL1A, MMP8
42leukotriene b444 59 2411.9IL8, IL1B, LAP3, RNPEP, IL1A, IL1R1
43serine449.9MMP8, HPGD, TLR4, NEU1, LTF, PEPD
44vegf449.8LAP3, MMP8, IL1B, IL8, IL1R1, LTF
45creatinine449.8IL1A, IL1R1, LTF, LAP3, MBL2, PEPD
46alanine449.8MMP8, RNPEP, IL1R1, TLR4, HPGD, LTF
47retinoic acid44 2410.8IL1A, IL1R1, LTF, DEFB4A, TLR4, LAP3
48cysteine449.7MMP8, IL8, IL1R1, HPGD, LAP3, DEFB4A
49dexamethasone44 49 28 1112.7IL1R1, IL8, LTF, DEFB4A, IL1B, IL1A
50nitric oxide44 11 2411.4IL1R1, TLR4, IL1B, MBL2, IL1A, MMP8

GO Terms for genes affiliated with Bacterial Vaginosis

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16Gene Ontology
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Cellular components related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0DEFB4A, DEFA3, DEFA5
2secretory granuleGO:0301419.8CRHBP, LTF, IL1B
3extracellular spaceGO:0056159.2MBL2, CRHBP, DEFA5, DEFA3, RNPEP, IL8
4extracellular regionGO:0055769.0MMP8, MBL2, PRF1, DEFA5, DEFA3, DEFB4A

Biological processes related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.4IL1B, IL1A
2killing of cells of other organismGO:03164010.2DEFA3, DEFA5
3positive regulation of interleukin-2 biosynthetic processGO:04508610.2IL1B, IL1A
4immune responseGO:0069559.9TLR4, DEFB4A, IL1R1, IL8, IL1A, IL1B
5defense response to bacteriumGO:0427429.9LTF, DEFB4A, DEFA3, DEFA5, MBL2, TLR4
6proteolysisGO:0065089.9LTF, RNPEP, MMP8, LAP3, PEPD
7innate immune responseGO:0450879.8DEFB4A, DEFA3, DEFA5, MBL2, TLR4
8inflammatory responseGO:0069549.7CRHBP, IL8, IL1A, IL1B

Molecular functions related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1A
2aminopeptidase activityGO:00417710.0PEPD, LAP3, RNPEP
3metalloexopeptidase activityGO:0082359.9LAP3, RNPEP

Products for genes affiliated with Bacterial Vaginosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacterial Vaginosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet