MCID: BCT002
MIFTS: 53

Bacterial Vaginosis malady

Summaries for Bacterial Vaginosis

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A bacterial infectious disease that is associated with a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.

MalaCards: Bacterial Vaginosis, also known as nsv - nonspecific vaginitis, is related to vulvovaginal candidiasis and arthritis. An important gene associated with Bacterial Vaginosis is PRF1 (perforin 1 (pore forming protein)), and among its related pathways are Senescence and Autophagy and Rheumatoid arthritis. The drugs acetic acid and metronidazole and the compounds pentoxifylline and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include colon, cervix and t cells, and related mouse phenotypes are tumorigenesis and hematopoietic system.

CDC:3 Any woman can get BV.

Wikipedia:64 Bacterial vaginosis (BV) or very uncommonly vaginal bacteriosis is a disease of the vagina caused by... more...

Aliases & Classifications for Bacterial Vaginosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

bacterial vaginosis 8 10 45 61
nsv - nonspecific vaginitis 8


External Ids:

Disease Ontology8 DOID:3385
MeSH35 D016585

Related Diseases for Bacterial Vaginosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to bacterial vaginosis

Clinical Features for Bacterial Vaginosis

Drugs & Therapeutics for Bacterial Vaginosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bacterial Vaginosis

Drug clinical trials:

Search ClinicalTrials for Bacterial Vaginosis

Search NIH Clinical Center for Bacterial Vaginosis

Search CenterWatch for Bacterial Vaginosis

Inferred drug relations via UMLS61/NDF-RT41:

Show with subtypes

Genetic Tests for Bacterial Vaginosis

Anatomical Context for Bacterial Vaginosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Bacterial Vaginosis:

33
Colon, Cervix, T cells, B cells

Animal Models for Bacterial Vaginosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Bacterial Vaginosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8IL1R1, IL1B, MMP8
2MP:00053979.6IL1A, IL8, IL1R1, LTF, PRF1, NEU1
3MP:00053879.1LAP3, TLR4, MBL2, NEU1, PRF1, LTF

Publications for Bacterial Vaginosis

Sources:
51PubMed
See all sources

Articles related to Bacterial Vaginosis:

(show top 50)    (show all 564)
idTitleAuthorsYear
1
Early Pregnancy Changes in Bacterial Vaginosis-Associated Bacteria and Preterm Delivery. (24405280)
2014
2
Proteome profiles of vaginal fluids from women affected by bacterial vaginosis and healthy controls: outcomes of rifaximin treatment. (23798671)
2013
3
Bacterial vaginosis: risks and treatment. (24121846)
2013
4
Associations between vaginal pathogenic community and bacterial vaginosis in Chinese reproductive-age women. (24124575)
2013
5
Vaginal biofilms and bacterial vaginosis: of mice and women. (23431034)
2013
6
Efficacy of methods used for the diagnosis of bacterial vaginosis. (23530888)
2013
7
Incident Herpes Simplex Virus Type 2 Infection Increases the Risk of Subsequent Episodes of Bacterial Vaginosis. (24273042)
2013
8
Intermediate vaginal flora and bacterial vaginosis are associated with the same factors: findings from an exploratory analysis among female sex workers in Africa and India. (24226098)
2013
9
Ability of chitosan gels to disrupt bacterial biofilms and their applications in the treatment of bacterial vaginosis. (23695992)
2013
10
Influence of early self-diagnosis and treatment of bacterial vaginosis on preterm birth rate. (22445423)
2012
11
Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria. (22719852)
2012
12
To determine of the prevalence of Bacterial Vaginosis, Candida sp, mixed infections (Bacterial Vaginosis + Candida sp), Trichomonas Vaginalis, Actinomyces sp in Turkish women from Ankara, Turkey. (23383559)
2012
13
Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta-analysis. (21223574)
2011
14
Severity of bacterial vaginosis and the risk of sexually transmitted infection. (21514555)
2011
15
A randomised controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with bacterial vaginosis: preliminary results. (22059409)
2011
16
Vitamin D deficiency and bacterial vaginosis in pregnancy: examining the link. (22900656)
2011
17
Pilot randomized trial for treatment of bacterial vaginosis using in situ forming metronidazole vaginal gel. (21410839)
2011
18
Dissimilarity in the occurrence of Bifidobacteriaceae in vaginal and perianal microbiota in women with bacterial vaginosis. (20620215)
2010
19
Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis. (19809829)
2010
20
Prevention of preterm birth is possible by vaginal pH screening, early diagnosis of bacterial vaginosis or abnormal vaginal flora and treatment. (21051849)
2010
21
Identification and in vitro production of Lactobacillus antagonists from women with or without bacterial vaginosis. (20209377)
2010
22
Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 to prevent or cure bacterial vaginosis among women with HIV. (20801446)
2010
23
Effect of treatment of asymptomatic bacterial vaginosis on HIV-1 shedding in the genital tract among women on antiretroviral therapy: a pilot study. (19694541)
2009
24
Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis. (19920869)
2009
25
Bacterial vaginosis: an overview for 2009. (19399292)
2009
26
Boric acid addition to suppressive antimicrobial therapy for recurrent bacterial vaginosis. (19704395)
2009
27
Can bacterial vaginosis help to find sexually transmitted diseases, especially chlamydial cervicitis? (19182056)
2009
28
Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. (19357214)
2009
29
The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. (19588379)
2009
30
Summaries for patients. Factors related to bacterial vaginosis that persists or occurs again after treatment in women who have sex with women. (18591629)
2008
31
Molecular quantification of Gardnerella vaginalis and Atopobium vaginae loads to predict bacterial vaginosis. (18513147)
2008
32
Screening for bacterial vaginosis in pregnancy to prevent preterm delivery: U.S. Preventive Services Task Force recommendation statement. (18252683)
2008
33
Bacterial vaginosis presence in sexually active women in Tuzla Canton area. (19125702)
2008
34
The efficacy and safety of a single dose of polyhexamethylene biguanide gynaecologic solution versus a seven-dose regimen of vaginal clindamycin cream in patients with bacterial vaginosis. (18401974)
2008
35
Asymptomatic bacterial vaginosis: is it time to treat? (17547871)
2007
36
Modulation of vaginal immune response among pregnant women with bacterial vaginosis by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, and yeast. (17306653)
2007
37
The Women's Health II Medical Education Network _Part 1: Understanding bacterial vaginosis: diagnosis, treatment, and improved outcomes. (18667133)
2007
38
Re: bacterial vaginosis in a cohort of Danish pregnant women: prevalence and relationship with preterm delivery, low birthweight and perinatal infections. (17378828)
2007
39
The relationship between resolution of asymptomatic bacterial vaginosis and spontaneous preterm birth in fetal fibronectin-positive women. (17980184)
2007
40
Changes in the diagnosis and management of bacterial vaginosis following clinical research. (17044224)
2006
41
Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. (16988245)
2006
42
Vaginal nitric oxide in pregnant women with bacterial vaginosis. (16836610)
2006
43
Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis. (17045832)
2006
44
Anaerobes in bacterial vaginosis. (17642997)
2003
45
Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. (12388968)
2002
46
Risk factors for and relationship between bacterial vaginosis and cervicitis in a high risk population for cervicitis in Southern Iran. (11523583)
2001
47
The determination of phospholipase A2 enzyme activity in the vaginal secretions of pregnant and non-pregnant women with bacterial vaginosis-and in culture exudates of its causative organisms. (15511858)
1997
48
Vaginal and cervical pH in bacterial vaginosis and cervicitis during pregnancy. (8582707)
1995
49
Direct Gram's stain of vaginal discharge as a means of diagnosing bacterial vaginosis. (1875389)
1991
50
Bacterial vaginosis as a risk factor for post-cesarean endometritis. (2296423)
1990

Genetic Variations for Bacterial Vaginosis

Expression for genes affiliated with Bacterial Vaginosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for genes affiliated with Bacterial Vaginosis

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 52QIAGEN, 53R&D Systems, 12EMD Millipore, 60Tocris Bioscience
See all sources

Pathways related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 30)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL8
210.3TLR4
310.3TLR4
410.3IL1A, IL1B
510.1IL1A, IL8, IL1B
610.1IL1R1, IL1A, IL1B
7
Hide members
10.1IL1R1, IL1A, IL1B
8
Hide members
10.1IL1B, IL1A, IL1R1
910.1IL1B, IL8, TLR4
10
Hide members
10.1TLR4, IL1R1, IL1B
1110.1IL1B, IL1A, TLR4
1210.1IL1R1, TLR4, IL1A
13
Hide members
10.0IL1B, IL8, IL1R1, TLR4
1410.0IL1B, IL8, IL1R1, TLR4
1510.0IL1B, TLR4, IL1R1, IL8
1610.0IL1B, IL1A, IL8, TLR4
1710.0TLR4, IL1B, IL8, IL1A
18
Hide members
10.0IL1A, IL1R1, TLR4, IL1B
19
Hide members
10.0IL1A, IL1B, TLR4, IL1R1
20
Hide members
10.0IL1R1, TLR4, IL1A, IL1B
21
Hide members
10.0TLR4, IL1R1, IL1A, IL1B
22
Hide members
10.0IL1R1, IL1B, IL1A, TLR4
2310.0TLR4, IL1B, IL1A, IL1R1
2410.0DEFA1, DEFA3, DEFA5
259.9DEFA3, DEFA1, LTF, MMP8
26
Hide members
9.9IL1B, IL8, IL1R1, TLR4, IL1A
27
Hide members
9.9IL1B, TLR4, IL1R1, IL1A, IL8
28
Immune response Bacterial infections in normal airways
Hide members
9.8IL1R1, DEFB4A, TLR4, IL8, IL1A, IL1B
29
Hide members
9.7DEFB104A, DEFA1, DEFB4A, DEFA3, DEFA5
30
Hide members
9.2IL1A, DEFB4A, IL1B, IL1R1, DEFB104A, DEFA1

Compounds for genes affiliated with Bacterial Vaginosis

Sources:
45Novoseek, 11DrugBank, 2BitterDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
See all sources

Compounds related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1pentoxifylline45 1111.6IL1R1, LTF
2endotoxin4510.5HPGD, LTF, DEFB4A
3fmlp4510.5IL1A, LTF
4hydrocortisone45 2 60 1113.5CRHBP, LTF, IL8
5monosodium urate4510.5IL1R1, IL1B, IL8
6muramyl dipeptide45 2911.5IL8, IL1B, TLR4
7tenidap45 2911.4IL1R1, IL1A, IL1B, LTF
8gold sodium thiomalate4510.4IL1A, IL8, IL1B, IL1R1
9sulfasalazine45 29 50 1113.4IL1R1, IL8, IL1A, IL1B
10flagellin45 2911.4IL1B, IL8, DEFB4A, TLR4
11pneumococcal4510.4LTF, NEU1, TLR4
12polyinosinic-polycytidylic acid4510.4IL1B, TLR4, IL8, IL1A
134-ipp6010.3IL1R1, IL1A, IL1B
14nacl4510.3DEFA1, IL1R1, LTF, DEFB4A
15diphenyleneiodonium4510.3IL1B, IL1R1, TLR4, IL8
16git 276010.3IL1R1, IL1A, IL1B
17il 104510.3IL1A, TLR4, IL1R1, IL8, IL1B
18ccl345 2911.3IL1R1, IL1A, IL8, TLR4, IL1B
19h2o24510.3MMP8, IL1R1, LAP3, LTF, NEU1
20polymyxin b4510.3TLR4, IL1B, IL1A, IL8, LTF, MBL2
21neopterin4510.2MBL2, IL8, IL1B, IL1A, IL1R1, LTF
22lipoteichoic acid4510.2MBL2, TLR4, DEFB4A, IL1R1, IL8, IL1B
23peptidoglycan45 2911.2TLR4, MBL2, IL8, DEFB4A, IL1B, IL1R1
24rantes4510.2IL1A, IL1B, DEFB4A, TLR4, MBL2, IL1R1
25cyclosporin a45 29 6012.2MMP8, IL1R1, LTF
26mannose4510.2DEFB4A, LTF, NEU1, TLR4, MBL2
27phosphatidylcholine4510.2NEU1, MBL2, LTF, PRF1
28estrogen4510.1LTF, PEPD, CRHBP, MBL2, DEFB4A
29sb 20358045 6011.1TLR4, IL1A, IL1B, IL8, IL1R1, DEFB4A
30hyaluronic acid45 2411.1IL1A, IL8, IL1B, PEPD, LTF, NEU1
31pirfenidone45 6011.1IL1B, IL1A, IL1R1
32histamine45 29 2412.1IL1B, DEFB4A, LTF, TLR4, IL8, NEU1
33anti-fungal4510.1TLR4, MBL2, DEFA3, LTF, DEFA1, DEFB4A
34pdtc4510.1IL1B, IL8, TLR4, IL1A
35actinomycin d4510.1IL8, IL1A, LTF, IL1B, IL1R1, TLR4
36prostaglandin4510.1IL1R1, IL1A, IL1B, HPGD, CRHBP
37as 10160 4511.0IL1B, IL1R1, IL1A
38superoxide45 2411.0MBL2, LTF, IL8, IL1B, MMP8, PEPD
39hbd24510.0IL8, TLR4, DEFA5, DEFA3, DEFB4A, DEFA1
40genistein45 29 60 2 11 2415.0TLR4, IL1A, DEFB4A, IL8, MMP8, IL1B
41progesterone45 60 29 11 2413.9MBL2, CRHBP, HPGD, IL1R1, IL1A, MMP8
42leukotriene b445 60 2411.9IL8, IL1B, LAP3, RNPEP, IL1A, IL1R1
43serine459.9MMP8, HPGD, TLR4, NEU1, LTF, PEPD
44vegf459.8LAP3, MMP8, IL1B, IL8, IL1R1, LTF
45creatinine459.8IL1A, IL1R1, LTF, LAP3, MBL2, PEPD
46alanine459.8MMP8, RNPEP, IL1R1, TLR4, HPGD, LTF
47retinoic acid45 2410.8IL1A, IL1R1, LTF, DEFB4A, TLR4, LAP3
48cysteine459.7MMP8, IL8, IL1R1, HPGD, LAP3, DEFB4A
49dexamethasone45 50 29 1112.7IL1R1, IL8, LTF, DEFB4A, IL1B, IL1A
50nitric oxide45 11 2411.4IL1R1, TLR4, IL1B, MBL2, IL1A, MMP8

GO Terms for genes affiliated with Bacterial Vaginosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.0DEFB4A, DEFA3, DEFA5
2secretory granuleGO:0301419.8CRHBP, LTF, IL1B
3extracellular spaceGO:0056159.2MBL2, CRHBP, DEFA5, DEFA3, RNPEP, IL8
4extracellular regionGO:0055769.0MMP8, MBL2, PRF1, DEFA5, DEFA3, DEFB4A

Biological processes related to Bacterial Vaginosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00166010.4IL1B, IL1A
2killing of cells of other organismGO:03164010.2DEFA3, DEFA5
3positive regulation of interleukin-2 biosynthetic processGO:04508610.2IL1B, IL1A
4immune responseGO:0069559.9TLR4, DEFB4A, IL1R1, IL8, IL1A, IL1B
5defense response to bacteriumGO:0427429.9LTF, DEFB4A, DEFA3, DEFA5, MBL2, TLR4
6proteolysisGO:0065089.9LTF, RNPEP, MMP8, LAP3, PEPD
7innate immune responseGO:0450879.8DEFB4A, DEFA3, DEFA5, MBL2, TLR4
8inflammatory responseGO:0069549.7CRHBP, IL8, IL1A, IL1B

Molecular functions related to Bacterial Vaginosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1A
2aminopeptidase activityGO:00417710.0PEPD, LAP3, RNPEP
3metalloexopeptidase activityGO:0082359.9LAP3, RNPEP

Products for genes affiliated with Bacterial Vaginosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacterial Vaginosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet