Bacterial Vaginosis malady

Disease Ontology: A bacterial infectious disease that is associated with a grayish vaginal discharge usually of foul odor and the presence of gardnerella vaginalis.⁶

MalaCards: Bacterial Vaginosis, also known as bacterial vaginosis (disorder), is related to vulvovaginal candidiasis and vulvovaginitis. An important gene associated with Bacterial Vaginosis is LAP3 (leucine aminopeptidase 3), and among its related pathways are Graft-versus-host disease and Immune response_Bacterial infections in normal airways. The drugs clindamycin phosphate pwdr [va product] and acetic acid liquid [va product] and the compounds ivig and hyaluronic acid have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and endocrine/exocrine gland.

CDC: Any woman can get BV.²

Wikipedia: Bacterial vaginosis (BV) or less commonly vaginal bacteriosis is a disease of the vagina caused by...⁴⁴ more...

Aliases & Descriptions:

bacterial vaginosis 6 32 43 bacterial vaginosis (disorder) 6

nsv - nonspecific vaginitis 6

Diseases related to bacterial vaginosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 659)

id	Related Disease	Score	Top Affiliating Genes
1	vulvovaginal candidiasis	31.1	LAP3, IL4, MBL2, DEFB4A, DEFA5
2	vulvovaginitis	30.0	LAP3, IL10, IL4, MBL2, HSPA4, LTF
3	candidiasis	27.8	LAP3, IL10, IL4, MBL2, LTF, TLR2
4	vaginitis	25.8	LAP3, MMP8, FN1, IL10, IL1A, IL1B
5	cervicitis	21.6	MMP8, FN1, FLT1, IL10, IL1A, IL1B
6	malignant histiocytosis	13.6	IL1A, IL1B, IL1R1
7	aggressive periodontitis	13.6	MMP8, IL1A, LTF
8	gastric cancer risk after h. pylori infection	13.5	IL1B, IL1RN
9	sheehan syndrome	13.5	CRH, SLPI, NEU1
10	somatoform disorder	13.5	IL1A, IL1B, IL1RN
11	meningococcemia	13.4	IL1A, IL1B, IL1RN
12	oral candidiasis	13.4	LTF, DEFB4A, SLPI
13	microsporidiosis	13.4	LTF, DEFA1, DEFB4A, DEFA5
14	status asthmaticus	13.4	IL1R1, IL1RN, IL8
15	rheumatoid arthritis	13.4	IL1R1, IL1RN, MBL2
16	bronchitis	13.4	IL8, LTF, SLPI
17	cinca syndrome	13.4	IL1B, IL1R1, IL1RAPL2
18	stenotrophomonas maltophilia	13.4	IL10, IL8
19	familial cold autoinflammatory syndrome	13.4	IL1B, IL1R1, IL1RAPL2
20	invasive aspergillosis	13.4	TLR2, TLR4
21	keratoconjunctivitis sicca	13.3	IL1A, IL4, LTF
22	central nervous system leukemia	13.3	IL1B, TNF
23	rheumatoid arthritis, progression of	13.3	FN1, IL10
24	ethmoid sinusitis	13.3	IL1B, IL4, IL8
25	muckle-wells syndrome	13.3	IL1B, IL1R1, IL1RAPL2, IL8
26	colorectal cancer	13.3	TLR2, TLR4
27	wells syndrome	13.3	IL1B, IL1R1, IL1RAPL2, IL8
28	bacterial meningitis	13.3	MMP8, IL1B, IL8, TLR2
29	coccidioidomycosis	13.2	IL10, MBL2, TLR4
30	endocervicitis	13.2	IL8, TLR4, DEFA5, SLPI
31	euthyroid sick syndrome	13.2	IL1B, IL6
32	eating disorder	13.2	CRH, CRHR1, CRHR2
33	mycobacterium marinum	13.2	IL8, TNF
34	pulpitis	13.2	IL1A, IL8, TNF
35	cryopyrin-associated periodic syndrome	13.2	IL1R1, IL1RAPL2
36	cardiac sarcoidosis	13.2	IL1A, IL1B, TNF
37	endophthalmitis	13.2	IL8, TNF, PRF1
38	cryptosporidiosis	13.2	IL1A, IL4, MBL2, LTF
39	periostitis	13.2	FLT1, IL1A, IL1B, IL1RN
40	alcoholic hepatitis	13.2	IL1A, IL8, TNF
41	anxiety disorder	13.2	CRH, CRHR1, CRHR2
42	polyarteritis nodosa	13.2	IL6, IL8, LTF
43	paratyphoid fever	13.2	IL1A, IL1B, IL1R1, TNF
44	localized scleroderma	13.1	IL4, IL8, DEFB4A
45	proctitis	13.1	IL8, TNF, LTF
46	radiculopathy	13.1	IL1A, IL1R1, IL6
47	head injury	13.1	IL1A, IL1B, IL6, IL8
48	rosacea	13.1	MMP8, FLT1, IL8, TLR2
49	cryptogenic organizing pneumonia	13.1	IL8, TNF
50	mesangial proliferative glomerulonephritis	13.1	FN1, IL6, MBL2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetic acid, acetic acid liquid [va product], acetic acid,glacial, clindamycin, clindamycin hydrochloride, clindamycin palmitate hydrochloride, clindamycin phosphate, clindamycin phosphate pwdr [va product], metronidazole, metronidazole hydrochloride, metronidazole pwdr [va product], povidone

MGI Mouse Phenotypes related to bacterial vaginosis:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.1	CRHR1, CRH
2	endocrine/exocrine gland phenotype	MP:0005379	10.0	HPGD, CRHR1, TLR2
3	integument phenotype	MP:0010771	9.4	NEU1, TLR4, TLR2, CRH, IL4, IL1R1
4	liver/biliary system phenotype	MP:0005370	9.3	TLR4, TLR2, IL6, IL1R1
5	nervous system phenotype	MP:0003631	9.0	NEU1, PRF1, TLR4, TLR2, PLA2G6, CRH
6	growth/size phenotype	MP:0005378	9.0	TLR4, PLA2G6, CRHBP, CRH, IL6, NEU1
7	skeleton phenotype	MP:0005390	8.9	NEU1, PLA2G6, PTGS2, IL6, IL1R1, FN1
8	mortality/aging	MP:0010768	7.9	NEU1, PRF1, TLR4, TLR2, PLA2G6, CRHR1
9	immune system phenotype	MP:0005387	7.7	MMP8, NEU1, TLR4, LTF, PLA2G6, CRHR2
10	adipose tissue phenotype	MP:0005375	7.6	PRKCA, TLR4, TLR2, CRHR2, PTGS2, TNF
11	behavior/neurological phenotype	MP:0005386	7.4	NEU1, PRF1, TLR4, TLR2, PLA2G6, CRHR2
12	tumorigenesis	MP:0002006	6.6	PRKCA, PRF1, TLR4, TLR2, PTGS2, TNF
13	homeostasis/metabolism phenotype	MP:0005376	6.6	LTF, TLR2, TLR4, PRF1, PRKCA, SLPI
14	vision/eye phenotype	MP:0005391	6.6	NEU1, TLR4, CRHR2, PTGS2, TNF, IL6
15	reproductive system phenotype	MP:0005389	6.4	TLR4, PLA2G6, PTGS2, TNF, HPGD, IL6
16	muscle phenotype	MP:0005369	6.3	PLA2G6, TLR2, TLR4, PRKCA, NEU1, PTGS2
17	cardiovascular system phenotype	MP:0005385	5.4	PTGS2, CRHR1, CRHR2, TLR2, TLR4, PRKCA
18	cellular phenotype	MP:0005384	5.3	CRH, PLA2G6, TLR2, TLR4, PRF1, SLPI

Articles related to bacterial vaginosis:

(show all 42)

id	Title	Authors	Year	Affiliating Genes
1	Evidence of a gene-environment interaction that predi sposes to spontaneous preterm birth: a role for asymptomatic bacterial vaginosi s and DNA variants in genes that control the inflammatory response. (20350647)	GA^mez L.M.... Parry S.	2010	FLT1, PRKCA, IL6
2	Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. (19285652)	Yeganegi M.... Bocking A.D.	2009	PTGS2, TLR4, HPGD
3	Effect of clindamycin treatment on vaginal inflammato ry markers in pregnant women with bacterial vaginosis and a positive fetal fibr onectin test. (19647824)	Diaz-Cueto L.... Arechavaleta-Velasco F.	2009	IL1B
4	Predicting risk of bacterial vaginosis: the role of race, smoking and corticotropin-releasing hormone-related genes. (19131402)	Ryckman K.K.... Williams S.M.	2009	CRHR1, CRH, CRHR2
5	Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery. (18757648)	Xu J.... Goepfert A.R.	2008	DEFA1, DEFA3
6	Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1beta. (17714681)	Cauci S.... McCollum K.	2008	PEPD
7	Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis. (18635180)	Fan S.R.... Liao Q.P.	2008	IL4, DEFA5, DEFB4A
8	TLR2-mediated cell stimulation in bacterial vaginosis. (17532476)	Mares D.... Spear G.T.	2008	TLR2
9	Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. (18462081)	Mitchell C.M.... Hitti J.E.	2008	IL1B, IL8, SLPI
10	Benefits of Affirm VPIII and L-PAP in the diagnosis of bacterial vaginosis (18588815)	Flores-Paz R.... Arriaga-Alba M.	2008	LAP3
11	Cytokines, pregnancy, and bacterial vaginosis: comparison of levels of cervical cytokines in pregnant and nonpregnant women with bacterial vaginosis. (17922400)	Beigi R.H.... Hillier S.L.	2007	IL8
12	Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis. (17470593)	Giraldo P.C.... Witkin S.S.	2007	MBL2
13	Association of interleukin-1beta and interleukin-1 receptor antagonist polymorphisms with bacterial vaginosis in non-pregnant Italian women. (17314118)	Cauci S.... Guaschino S.	2007	IL1B, IL1R1, IL1RN
14	Genital tract interleukin-8 but not interleukin-1beta or interleukin-6 concentration is associated with bacterial vaginosis and its clearance in HIV-infected and HIV-uninfected women. (18273408)	Losikoff P.... Mayer K.H.	2007	IL1B, IL8
15	The role of mannose-binding lectin gene polymorphisms in women with recurrent bacterial vaginosis. (17678865)	De Seta F.... Guaschino S.	2007	MBL2
16	Vaginal matrix metalloproteinase levels in pregnant women with bacterial vaginosis. (16872847)	Diaz-Cueto L.... Arechavaleta-Velasco F.	2006	MMP8
17	Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. (16988245)	Valore E.V.... Ganz T.	2006	IL8
18	Vaginal nitric oxide in pregnant women with bacterial vaginosis. (16836610)	GenAs M.R.... Witkin S.S.	2006	IL1B, IL1RN, HSPA4
19	Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin-8 are not associated with bacterial vaginosis during pregnancy. (16038986)	Diaz-Cueto L.... Arechavaleta-Velasco F.	2005	IL8
20	Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis. (15871126)	Zariffard M.R.... Spear G.T.	2005	TLR2, TLR4
21	Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy. (16202743)	Goepfert A.R.... Langer O.	2005	TNF, IL6, IL1B
22	Relationship between a toll-like receptor-4 gene polymorphism, bacterial vaginosis-related flora and vaginal cytokine responses in pregnant women. (15358455)	Genc M.R.... Witkin S.S.	2004	TLR4
23	A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth. (15284722)	Macones G.A.... Strauss J.F.	2004	TNF
24	Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women. (12529421)	Cauci S.... Quadrifoglio F.	2003	IL1B, IL8
25	Does bacterial vaginosis alter the sensitivity of screening tests for Chlamydia trachomatis? An analysis of patient characteristics. (12869223)	Hussey J.... Turner A.J.	2003	LAP3
26	Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. (12616147)	Olmsted S.S.... Hillier S.L.	2003	RNPEP
27	Correlation of local interleukin-1beta levels with specific IgA response against Gardnerella vaginalis cytolysin in women with bacterial vaginosis. (12148539)	Cauci S.... Quadrifoglio F.	2002	IL1B, PRF1
28	Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. (12023767)	Cauci S.... Quadrifoglio F.	2002	IL8, PEPD
29	Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora. (12388968)	Cauci S.... Eschenbach D.A.	2002	PRF1, PEPD
30	Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis. (11845812)	Donder G.G.... Spitz B.	2002	IL1B
31	Impairment of the mucosal immune system: IgA and IgM cleavage detected in vaginal washings of a subgroup of patients with bacterial vaginosis. (9815222)	Cauci S.... Quadrifoglio F.	1998	PRF1
32	IL-1beta, IL-6, TNFalpha, fetal fibronectin, and endotoxin in the lower genital tract of pregnant women with bacterial vaginosis. (9740515)	Mattsby-Baltzer I.... RosAcn P.	1998	IL1B, IL1A
33	Evaluation of a fast test to identify the presence of proline aminopeptidase in women with bacterial vaginosis. (18476142)	Calderon E.... Conde-Glez C.	1997	LAP3
34	The determination of phospholipase A2 enzyme activity in the vaginal secretions of pregnant and non-pregnant women with bacterial vaginosis-and in culture exudates of its causative organisms. (15511858)	Jones B.M.... Al-Mushrif S.	1997	PLA2G6
35	Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis. (8946639)	Rein M.F.... Guerrant R.L.	1996	LTF
36	Correlation between the clinical diagnosis of bacterial vaginosis and the results of a proline aminopeptidase assay. (18475340)	Nelson G.H.... Bacon J.L.	1994	LAP3
37	Endotoxin and interleukin-1 alpha in the cervical mucus and vaginal fluid of pregnant women with bacterial vaginosis. (8238178)	Platz-Christensen J.J.... Wiqvist N.	1993	IL1A
38	Diagnostic microbiology of bacterial vaginosis. (8357044)	Hillier S.L.	1993	LAP3
39	Is trichomoniasis often associated with bacterial vaginosis in pregnant adolescents? (1372472)	James J.A.... Hanson L.	1992	LAP3
40	Sialidases (neuraminidases) in bacterial vaginosis an d bacterial vaginosis-associated microflora. (1551983)	Briselden A.M.... Hillier S.L.	1992	NEU1
41	A new proline aminopeptidase assay for diagnosis of bacterial vaginosis. (1892204)	Schoonmaker J.N.... McGregor J.A.	1991	LAP3
42	Bacterial vaginosis: diagnostic and pathogenetic findings during topical clindamycin therapy. (2201189)	Livengood C.H.... Hill G.B.	1990	LAP3

Genes related to bacterial vaginosis according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	LAP3	leucine aminopeptidase 3	11.0	Publications
2	PRF1	perforin 1 (pore forming protein)	11.0	Publications
3	PEPD	peptidase D	11.0	Publications
4	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
5	IL8	interleukin 8	11.0	Publications
6	IL1B	interleukin 1, beta	11.0	Publications
7	IL1A	interleukin 1, alpha	11.0	Publications
8	IL1R1	interleukin 1 receptor, type I	11.0	Publications
9	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
10	LTF	lactotransferrin	11.0	Publications
11	DEFA3	defensin, alpha 3, neutrophil-specific	11.0	Publications
12	RNPEP	arginyl aminopeptidase (aminopeptidase B)	11.0	Publications
13	DEFA5	defensin, alpha 5, Paneth cell-specific	11.0	Publications
14	DEFA1	defensin, alpha 1	11.0	Publications
15	CRHBP	corticotropin releasing hormone binding protein	11.0	Publications
16	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	11.0	Publications
17	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications
18	CRHR2	corticotropin releasing hormone receptor 2	11.0	Publications
19	DEFB4A	defensin, beta 4A	11.0	Publications
20	SLPI	secretory leukocyte peptidase inhibitor	11.0	Publications
21	TLR4	toll-like receptor 4	11.0	Publications
22	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	11.0	Publications
23	CRH	corticotropin releasing hormone	11.0	Publications
24	CRHR1	corticotropin releasing hormone receptor 1	11.0	Publications
25	TLR2	toll-like receptor 2	11.0	Publications
26	HSPA4	heat shock 70kDa protein 4	11.0	Publications
27	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
28	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
29	FN1	fibronectin 1	11.0
30	IL4	interleukin 4	11.0	Publications
31	TNF	tumor necrosis factor	11.0	Publications
32	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
33	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
34	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
35	IL10	interleukin 10	11.0	Publications
36	PRKCA	protein kinase C, alpha	11.0	Publications

Pathways related to bacterial vaginosis according to GeneDecks:

(show top 50)    (show all 86)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.5	IL1A, PRF1
2	Immune response_Bacterial infections in normal airways41	10.4	DEFB4A, IL1R1, IL1B
3	Bacterial infections in CF airways41	10.3	IL1R1, TLR2, DEFB4A
4	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.2	IL6
5	Immune System38	10.0	DEFB4A, DEFA5, DEFA3, DEFA1, IL1R1
6	NFAT Signaling and Lymphocyte Interactions36	9.7	IL4, IL1A
7	HMGB1 Pathway36	9.6	IL1A, IL1B, IL1R1, TNF, TLR4
8	TRAF Pathway36	9.5	IL1R1, IL1B, TLR2, TLR4, IL1A, TNF
9	IL-6 Pathway36	9.3	IL10, IL4, IL8
10	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.3	TLR2, TLR4, IL6, IL4, IL1B
11	Molecular Mechanisms of Cancer36	9.2	PRKCA, IL6, IL1R1, FN1
12	Th17 Differentiation37	9.2	IL1R1, IL6, TLR2, TLR4, IL1B
13	Hematopoietic cell lineage20	9.1	IL6, TNF, IL4, IL1R1, IL1B, IL1A
14	Immune response_MIF in innate immunity response41	9.0	IL6, IL8, TNF, PTGS2, TLR4, IL1B
15	Immune response_TLR signaling pathways41	9.0	TLR4, TLR2, IL8, IL4, FN1, IL6
16	Immune response MIF in innate immunity response10	9.0	PTGS2, IL1B, IL6, IL8, TNF, TLR4
17	Toll-like receptor signaling pathway20	9.0	IL6, IL8, TNF, IL1B, TLR4, TLR2
18	Immune response IL-1 signaling pathway10	9.0	TNF, IL8, IL6, IL1R1, IL1B, IL1A
19	Immune response_IL-1 signaling pathway41	9.0	PTGS2, TNF, IL8, IL6, IL1R1, IL1B
20	Rheumatoid arthritis20	8.8	IL1B, TLR4, TNF, IL8, IL6, FLT1
21	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.8	PRKCA, IL6, IL1B, IL1A, TNF
22	NF-KappaB (p50-p65) Pathway36	8.7	FLT1, IL1A, IL1B, IL1R1, IL6, TNF
23	Influenza A20	8.7	IL1B, IL1A, IL8, IL6, TLR4, TNF
24	IL-10 Pathway36	8.7	TLR4, IL10, IL1B, IL6, TNF, IL1A
25	PGC1Alpha Pathway36	8.6	IL10, IL1B, IL6, IL1A, IL8, IL4
26	Pertussis20	8.5	IL1B, IL6, IL8, TNF, TLR4, IL1A
27	Chagas disease (American trypanosomiasis)20	8.5	TLR4, TNF, IL6, IL10, IL1B, TLR2
28	Cytokine Network36	8.4	IL1B, IL10, TNF, IL1A, IL8, IL4
29	Malaria20	8.4	IL1B, IL8, TNF, TLR2, TLR4, IL6
30	African trypanosomiasis20	8.4	TNF, IL6, IL1B, IL10, PRKCA
31	PEDF Induced Signaling36	8.3	IL1B, IL8, IL10, TNF, IL6, IL4
32	Glucocorticoid Receptor Signaling36	8.3	IL1B, IL10, IL1A, IL1R1, IL4, IL6
33	TGF-Beta Pathway36	8.3	IL1R1, IL6, IL8, IL4, FLT1, IL10
34	NF-KappaB Family Pathway36	8.3	FLT1, IL1A, IL1B, IL1R1, TNF, TLR2
35	Akt Signaling36	8.2	IL10, IL6, IL4, TNF
36	Tuberculosis20	8.2	IL6, TLR4, TLR2, IL1B, IL1A, TNF
37	STAT3 Pathway36	8.2	IL10, IL1R1, IL1B, IL1A, IL6, IL8
38	Leishmaniasis20	8.1	TLR4, IL1A, IL1B, PTGS2, TNF, IL4
39	Endothelin-1 Signaling Pathway36	8.1	FLT1, IL1A, IL10, IL1B, IL4, IL6
40	Tec Kinases Signaling36	8.0	IL10, IL4, IL6, TLR2, TLR4, PRKCA
41	Cytokine-cytokine receptor interaction20	7.9	IL1R1, TNF, IL6, IL4, IL1B, IL1A
42	MAPK Family Pathway36	7.9	IL4, IL6, IL1R1, IL8, TNF, IL10
43	PAK Pathway36	7.8	TNF, IL8, FLT1, IL10, IL1A, IL1B
44	MIF Mediated Glucocorticoid Regulation36	7.7	IL1B, PTGS2, TNF, TLR4, IL8, IL6
45	MIF Regulation of Innate Immune Cells36	7.7	TNF, IL1A, IL1B, IL4, IL6, IL8
46	all-trans-Retinoic Acid Signaling in Brain36	7.7	IL4, IL10, IL1A, IL1B, IL6, IL8
47	ERK Signaling36	7.6	FLT1, PRKCA, FN1, IL6, IL4, IL1A
48	Amoebiasis20	7.4	IL10, PRKCA, TLR4, TLR2, TNF, IL8
49	p38 Signaling36	7.4	IL8, IL1B, IL4, FLT1, IL1R1, IL1A
50	Antioxidant Action of Vitamin-C36	7.2	IL1A, IL10, IL1B, IL1R1, IL4, IL6

Compounds related to bacterial vaginosis according to GeneDecks:

(show top 50)    (show all 258)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.1	IL1RAPL2
2	hyaluronic acid32 18	10.8	NEU1, PEPD, SLPI, LTF, FN1
3	calcitriol32 42 9 18 9	13.5	HPGD, SLPI, PRKCA, TLR2
4	endotoxin32	9.4	SLPI, DEFB4A, IL1R1, IL1RAPL2, HPGD, LTF
5	leflunomide32 9 9	11.1	TNF, IL1R1, IL6, IL1RN
6	anti-fungal32	9.0	MBL2, TLR2, TLR4, DEFA1, DEFA3, DEFB4A
7	h2o232	9.0	TLR4, IL1RN, IL1RAPL2, MMP8, LAP3, LTF
8	hbd232	9.0	IL1B, IL6, IL8, TLR2, TLR4, DEFA1
9	sulfasalazine32 9 9	11.0	IL1RAPL2, IL1R1, IL1B, TNF, IL1A, IL1RN
10	tenidap42 32	9.9	IL1R1, IL1B, IL1A, IL6, TNF, LTF
11	sb 20358032 42	9.8	IL6, HSPA4, TNF, CRH, PLA2G6, IL1R1
12	polyinosinic-polycytidylic acid32	8.6	TLR4, TLR2, IL8, IL10, IL4, IL6
13	cysteine32	8.5	LAP3, MMP8, SLPI, NEU1, FN1, HPGD
14	corticosterone32 18	9.4	IL1B, IL1A, IL1RN, IL1R1, IL1RAPL2, CRH
15	estrogen32	8.3	IL1RN, HPGD, CRH, CRHBP, CRHR1, LTF
16	il-1232	8.2	IL10, IL4, IL6, IL8, TNF, IL1R1
17	anakinra32 9 9	10.0	TNF, IL6, IL1B, IL1R1, IL1RAPL2, IL1RN
18	ccl332	8.0	IL1A, IL6, TNF, IL1R1, IL1B, IL10
19	rantes32	7.9	IL1A, IL1R1, IL1RAPL2, IL4, IL6, MBL2
20	imiquimod32 42 9 9	10.8	IL10, IL1RAPL2, IL1A, IL6, IL8, TNF
21	fibrinogen32	7.7	FN1, IL1R1, IL1RAPL2, IL1RN, IL6, MBL2
22	pge232	7.7	LTF, TLR2, TLR4, SLPI, PLA2G6, CRH
23	etanercept32 9 9	9.6	IL1R1, IL10, IL1RN, IL1RAPL2, TNF, IL6
24	creatinine32	7.6	HSPA4, CRH, PLA2G6, LTF, SLPI, PEPD
25	peptidoglycan32	7.5	DEFB4A, IL10, IL1B, IL1R1, IL1RN, IL6
26	leukotriene b432 42 18	9.4	IL6, IL8, HPGD, TNF, RNPEP, LTF
27	lipoteichoic acid32	7.4	IL10, IL1B, IL1R1, IL1RN, IL6, IL8
28	superoxide32 18	8.3	PEPD, SLPI, FLT1, IL1B, IL1RAPL2, IL1RN
29	polymyxin b32	7.3	IL10, IL1A, IL1RN, IL4, IL6, IL8
30	infliximab32 9 9	9.3	IL1RN, IL1B, IL1R1, IL1RAPL2, IL4, IL6
31	pentoxifylline32 9 9	9.2	IL10, IL1A, IL1B, IL1R1, IL1RAPL2, IL1RN
32	histamine32 18	8.1	IL1RAPL2, NEU1, SLPI, IL1RN, IL4, CRH
33	vitamin d32	7.1	CRH, IL6, TLR2, MBL2, SLPI, TLR4
34	genistein32 9 18 9	10.0	MMP8, PLA2G6, FN1, FLT1, IL1A, IL1B
35	tgf beta132	7.0	IL1RN, TNF, IL6, FLT1, IL1RAPL2, IL10
36	neopterin32	7.0	LTF, TNF, IL10, IL1A, IL1B, IL1R1
37	simvastatin32 34 42 9 18 9	11.8	IL1A, IL10, IL1RAPL2, TNF, IL1RN, TLR2
38	il 1032	6.8	IL10, IL1A, IL1B, IL1R1, IL1RAPL2, IL1RN
39	prostaglandin32	6.8	IL1A, IL1B, IL1R1, IL1RAPL2, IL1RN, IL6
40	hydrocortisone32 9 9	8.6	PLA2G6, LTF, SLPI, FLT1, IL10, IL1A
41	vegf32	6.6	LAP3, LTF, PRKCA, SLPI, PTGS2, HSPA4
42	alanine32	6.6	TLR4, TLR2, LTF, CRHR1, RNPEP, LAP3
43	actinomycin d32	6.3	TLR4, SLPI, TLR2, LTF, FN1, IL1A
44	indomethacin32 9 9	7.9	IL1RAPL2, IL1RN, IL4, IL6, HSPA4, HPGD
45	cyclosporin a32 42	6.8	MMP8, FN1, IL10, IL1A, IL1RAPL2, IL1RN
46	retinoic acid32 42 18	7.7	NEU1, TLR2, LTF, PLA2G6, TNF, HSPA4
47	serine32	5.4	IL1RN, IL1RAPL2, IL1R1, IL1A, LAP3, MMP8
48	nitric oxide32 9 18 9	8.0	MMP8, FN1, FLT1, IL10, IL1A, IL1B
49	cycloheximide32	4.3	TLR2, TLR4, NEU1, SLPI, PRKCA, PRF1
50	dexamethasone32 42 34 9 9	8.0	FN1, IL10, IL1A, IL1B, IL1R1, IL1RAPL2

Cellular components related to bacterial vaginosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	9.9	IL1B, CRHBP, LTF, DEFA5
2	extracellular region	GO:005576	7.1	RNPEP, LTF, DEFA3, DEFB4A, DEFA5, PRF1
3	extracellular space	GO:005615	5.7	MMP8, DEFA5, DEFA3, RNPEP, CRHBP, CRH

Biological processes related to bacterial vaginosis according to GeneDecks:

(show all 50)

id	Name	GO ID	Score	Top Affiliating Genes
1	chronic inflammatory response to antigenic stimulus	GO:002439	10.4	IL1B, IL1RN
2	fever generation	GO:001660	10.4	IL1B, IL1A
3	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	10.2	TNF, IL1B
4	positive regulation of interleukin-8 production	GO:032757	10.2	TLR4, TLR2, IL1B
5	sequestering of triglyceride	GO:030730	10.2	TNF, IL1B
6	parturition	GO:007567	10.2	CRHR1, CRH, HPGD
7	positive regulation vascular endothelial growth factor production	GO:010575	10.1	PTGS2, IL1B, IL1A
8	ovulation	GO:030728	10.0	PTGS2, HPGD, IL1R1, IL1B
9	positive regulation of mitosis	GO:045840	10.0	IL1A, IL1B, TNF
10	positive regulation of JNK cascade	GO:046330	9.9	IL1A, IL1B, TNF, TLR4
11	positive regulation of chemokine biosynthetic process	GO:045080	9.9	IL1B, IL4, TNF
12	response to ozone	GO:010193	9.9	IL1B, IL1A
13	positive regulation of fever generation	GO:031622	9.9	PTGS2, TNF, IL1B
14	positive regulation of NF-kappaB import into nucleus	GO:042346	9.9	TLR4, TLR2, TNF, IL1B
15	positive regulation of interferon-gamma production	GO:032729	9.9	TLR4, TNF, IL1B
16	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	IL1B, TNF, TLR2, TLR4
17	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.8	TNF, IL1B
18	response to organic nitrogen	GO:010243	9.8	IL1A, IL1B, IL1RN, PTGS2
19	neutrophil chemotaxis	GO:030593	9.8	IL1B, IL8, PRKCA
20	positive regulation of angiogenesis	GO:045766	9.7	PRKCA, IL1B, IL1A, FLT1
21	learning or memory	GO:007611	9.7	PRKCA, CRHBP, CRH
22	regulation of sensory perception of pain	GO:051930	9.6	TLR4, IL1A, IL10
23	response to hypoxia	GO:001666	9.6	TLR4, TNF, IL1B, IL1A, FLT1
24	regulation of isotype switching	GO:045191	9.6	IL10, IL4
25	acute-phase response	GO:006953	9.5	MBL2, IL6, IL1RN, FN1
26	defense response to Gram-positive bacterium	GO:050830	9.5	IL6, MBL2, TNF, TLR2
27	response to ethanol	GO:045471	9.5	PRKCA, PRF1, TLR4, IL4
28	receptor biosynthetic process	GO:032800	9.5	TNF, IL10
29	positive regulation of chemokine production	GO:032722	9.5	TLR4, TLR2, TNF, IL6
30	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.5	PRKCA, TLR4, TNF, IL1B, IL1A
31	positive regulation of nitric oxide biosynthetic process	GO:045429	9.4	TLR4, TLR2, PTGS2, TNF, IL1B
32	positive regulation of MHC class II biosynthetic process	GO:045348	9.4	TLR4, IL4, IL10
33	negative regulation of interleukin-6 production	GO:032715	9.4	TLR4, TNF, IL10
34	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.3	TLR4, TLR2, TNF, IL6, IL1B
35	type 2 immune response	GO:042092	9.3	IL4, IL10
36	negative regulation of growth of symbiont in host	GO:044130	9.3	TLR2, TNF, MBL2, IL10
37	positive regulation of cytokine secretion	GO:050715	9.3	TLR2, TNF, IL1A, IL10
38	positive regulation of interleukin-6 production	GO:032755	9.2	TLR4, TLR2, TNF, IL6, IL1B, IL1A
39	defense response to bacterium	GO:042742	9.2	DEFA5, DEFB4A, DEFA3, TLR4, LTF, IL10
40	response to activity	GO:014823	9.2	TLR4, TNF, IL10
41	female pregnancy	GO:007565	9.1	CRHR1, CRHBP, CRH, HPGD, IL4, IL1RN
42	response to organic cyclic compound	GO:014070	9.1	PRKCA, PTGS2, IL4, IL1RN, IL1A
43	innate immune response	GO:045087	9.0	DEFA5, DEFB4A, DEFA3, TLR4, TLR2, MBL2
44	immune response	GO:006955	8.9	DEFB4A, TLR4, TLR2, CRHR1, IL8, IL4
45	positive regulation of smooth muscle cell proliferation	GO:048661	8.7	PRKCA, PTGS2, TNF, IL6, FLT1
46	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	8.6	TNF, IL6, IL4, IL1B, IL10
47	negative regulation of cell proliferation	GO:008285	8.5	PRKCA, PTGS2, TNF, IL8, IL6, IL1B
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	TLR2, TNF, IL6, IL4, IL1B, IL1A
49	response to glucocorticoid stimulus	GO:051384	8.3	PTGS2, TNF, IL6, IL1RN, IL1B, IL10
50	inflammatory response	GO:006954	7.7	IL10, TLR2, CRHBP, CRH, PTGS2, TNF

Molecular functions related to bacterial vaginosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	aminopeptidase activity	GO:004177	10.1	LAP3, RNPEP, PEPD
2	interleukin-1 receptor binding	GO:005149	9.8	IL1RN, IL1B, IL1A
3	corticotrophin-releasing factor receptor activity	GO:015056	9.7	CRHR1, CRHR2
4	cytokine activity	GO:005125	8.1	IL10, IL1A, IL1B, IL4, IL6, TNF