MCID: BCT004
MIFTS: 55

Bacteriuria malady

Summaries for Bacteriuria

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine, bacteriuria denotes the presence of bacteria in urine not due to contamination from urine... more...

MalaCards: Bacteriuria is related to pyuria and diabetes mellitus. An important gene associated with Bacteriuria is UMOD (uromodulin), and among its related pathways are Th17 Differentiation and Cell adhesion ECM remodeling. The drugs methenamine and methenamine hippurate and the compounds gamma globulin and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and colon, and related mouse phenotypes are renal/urinary system and cellular.

Disease Ontology:8 A urinary system disease which consists of the presence of bacteria in urine.

Aliases & Classifications for Bacteriuria

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

bacteriuria 8 10 44 60


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Disease Ontology8 DOID:1412
SNOMED-CT56 61373006
MeSH34 D001437

Related Diseases for Bacteriuria

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17GeneCards, 18GeneDecks
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Diseases related to Bacteriuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1pyuria31.1CRP
2diabetes mellitus30.8CD79A, CD40LG, CRP, UMOD, CAT
3cystitis30.6UMOD
4pyelonephritis30.6TLR4, UMOD, CRP, CD79A, CXCR1
5acute pyelonephritis30.4CXCR1, CRP
6prostatitis30.4CD79A
7urethritis30.2CD79A
8pneumonia30.1TLR4, TLR2, TLR5, CRP, PRF1, CD79A
9nephrotic syndrome30.0CD79A
10chronic pyelonephritis30.0UMOD
11hypertension30.0CRP, CD79A
12leprosy29.8TLR2
13vesicoureteral reflux29.8UMOD
14multiple sclerosis29.8CXCR2, CXCR1
15prostate cancer29.8CXCR1, CXCR2
16peritonitis29.8CRP, TLR2
17proteinuria29.8UMOD, CRP, CD40LG, CD79A
18chorioamnionitis29.8IL8, CRP, TLR2, TLR4
19arthritis29.8IL8, CXCR1, CXCR2, CRP, TLR2, TLR4
20rheumatoid arthritis29.8TLR4, TLR2, CRP, CD40LG, CD79A, CXCR2
21neurogenic bladder10.5
22acute cystitis10.3
23type 2 diabetes mellitus10.2
24urethral syndrome10.1
25schistosomiasis10.1
26urinary schistosomiasis10.0
27sickle cell anemia10.0
28spina bifida10.0
29urinary tract obstruction10.0
30vaginitis10.0
31uveitis10.0CXCR1
32myocarditis10.0PRF1
33neutropenia10.0CXCR1
34eosinophilic pneumonia10.0ADAM8
35legionnaires' disease10.0TLR5
36viral hepatitis10.0TLR2
37pertussis10.0CD79A
38purpura10.0CD79A
39hyperuricemia10.0BCKDHA, UMOD
40q fever10.0CD79A
41brucellosis10.0CD79A
42reactive arthritis10.0CD79A
43guillain-barre syndrome10.0CD40LG
44dermatitis10.0CD79A
45leptospirosis10.0CD40LG
46gastroenteritis10.0CD79A
47thyroiditis10.0CD79A
48candidiasis10.0CD79A
49typhoid fever10.0CD79A
50chronic granulomatous disease10.0CAT

Graphical network of the top 20 diseases related to Bacteriuria:



Diseases related to bacteriuria

Clinical Features for Bacteriuria

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Drugs & Therapeutics for Bacteriuria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bacteriuria

Drug clinical trials:

Search ClinicalTrials for Bacteriuria

Search NIH Clinical Center for Bacteriuria

Search CenterWatch for Bacteriuria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Bacteriuria

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Anatomical Context for Bacteriuria

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32MalaCards
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MalaCards organs/tissues related to Bacteriuria:

32
Testes, Spinal cord, Colon, Kidney, Prostate, Brain, Heart, B cells

Animal Models for Bacteriuria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bacteriuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.3CXCR2, UMOD, TLR2, TLR4
2MP:00053847.2TIRAP, CAT, TLR4, TLR2, TLR5, PRF1
3MP:00053977.2UMOD, TLR5, TLR2, TLR4, TIRAP, PRF1
4MP:00053876.9ADAM8, TIRAP, TLR4, TLR2, TLR5, TLR1
5MP:00053766.7TLR5, TLR2, TLR4, CAT, TIRAP, UMOD

Publications for Bacteriuria

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50PubMed
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Articles related to Bacteriuria:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Bacteriuria and urinary tract infection after urodynamic examination of spinal cord injury patients. (23567758)
2013
2
Reduction of urinary catheter use and prescription of antibiotics for asymptomatic bacteriuria in hospitalised patients in internal medicine: before-and-after intervention study. (23740332)
2013
3
Fosfomycin trometamol: a review of its use as a single-dose oral treatment for patients with acute lower urinary tract infections and pregnant women with asymptomatic bacteriuria. (24202878)
2013
4
Asymptomatic bacteriuria: when the treatment is worse than the disease. (22143416)
2012
5
Comparison of asymptomatic bacteriuria Escherichia coli isolates from healthy individuals versus those from hospital patients shows that long-term bladder colonization selects for attenuated virulence phenotypes. (22104113)
2012
6
Staphylococcus aureus Bacteriuria: Source, Clinical Relevance, and Management. (22945379)
2012
7
Death and cardiovascular events after bacteriuria among adult women with chronic kidney disease. (23204852)
2012
8
Preventing the inappropriate treatment of asymptomatic bacteriuria at a community teaching hospital. (23882368)
2012
9
Asymptomatic bacteriuria - prevalence in the elderly population. (22003486)
2011
10
Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum I^-lactamase in spinal cord injury patients with recurrent bacteriuria. (21888562)
2011
11
Overactive bladder in women: does low-count bacteriuria matter? A review. (21046657)
2011
12
Screening and treating asymptomatic bacteriuria in pregnancy. (20139763)
2010
13
Systematic screening and treatment of asymptomatic bacteriuria in renal transplant recipients. (20720526)
2010
14
Asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group B streptococcus. (19834868)
2010
15
The impact of decreasing urinary IgA levels on decreased bacteriuria in a rat model of ileal augmented bladder. (19010498)
2009
16
Re: Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study: D. A. Wing, P. J. Rumney, C. W. Preslicka and J. H. Chung J Urol 2008; 180: 1367-1372. (19157436)
2009
17
The clinical significance of concurrent Staphylococcus aureus bacteriuria in patients with S. aureus bacteremia. (19539997)
2009
18
Nosocomial bacteriuria in patients with indwelling catheter after radical retropubic prostatectomy for prostate cancer. (19077397)
2008
19
Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey. (18379242)
2008
20
Comparison of three automated urinalysis systems--Bayer Clinitek Atlas, Roche Urisys 2400 and Arkray Aution Max for testing urine chemistry and detection of bacteriuria. (17049339)
2007
21
The prevalence of asymptomatic bacteriuria in long term care facility residents in Shiraz, Southwest Iran: a cross-sectional study. (19090248)
2007
22
There is a low incidence of recurrent bacteriuria in painful bladder syndrome/interstitial cystitis patients followed longitudinally. (17036170)
2007
23
Reducing antibiotic overuse: a call for a national performance measure for not treating asymptomatic bacteriuria. (17968830)
2007
24
Microbiological outcomes in women with diabetes and untreated asymptomatic bacteriuria. (16389540)
2006
25
Risk factors for bacteriuria due to Pseudomonas aeruginosa or Enterococcus spp in patients hospitalized via the emergency department. (16786380)
2006
26
Urine cytokines profile in renal transplant patients with asymptomatic bacteriuria. (16794530)
2006
27
Bacteriuria management and urological evaluation of patients with spina bifida and neurogenic bladder: a multicenter survey. (15592079)
2005
28
Evaluation and importance of asymptomatic bacteriuria in pregnancy. (16440822)
2005
29
Review: silver alloy catheters are more effective than standard catheters for reducing bacteriuria in adults in hospital having short term catheterisation. (15252913)
2004
30
Presence of bacteriuria caused by trimethoprim resistant bacteria in patients prescribed antibiotics: multilevel model with practice and individual patient data. (15166067)
2004
31
Management of asymptomatic bacteriuria in patients with diabetes mellitus. (14970371)
2004
32
Asymptomatic bacteriuria. Clinical significance and management. (14527770)
2003
33
Uricult trio as a screening test for bacteriuria in pregnancy. (12056364)
2002
34
Covert bacteriuria in nephrotic syndrome. (12593564)
2002
35
Evaluation of the Coral UTI Screen system for rapid automated screening of significant bacteriuria in a regional centralized laboratory. (12376024)
2002
36
Urinary interleukin-8 with asymptomatic bacteriuria in pregnancy. (11275031)
2001
37
Asymptomatic bacteriuria in institutionalized elders in Israel. (12812530)
2001
38
Evaluation of two methods for improving quality of diagnosis of bacteriuria by culture in primary healthcare. (11003258)
2000
39
Duration of treatment for asymptomatic bacteriuria during pregnancy. (10796207)
2000
40
Preventing catheter-related bacteriuria: should we? Can we? How? (10219925)
1999
41
Clinical evaluation of a rapid diagnostic screen (URISCREEN) for bacteriuria in children. (8996393)
1997
42
Urinary symptoms, sexual intercourse and significant bacteriuria in male patients attending STD clinics. (9215109)
1997
43
Typing of proteus from patients with bacteriuria. (8683538)
1996
44
Urinary symptoms, sexual intercourse and significant bacteriuria in male patients attending STD clinics. (8976831)
1996
45
Reduction of bacteriuria and pyuria after ingestion of cranberry juice. (8093138)
1994
46
Pyuria: its relationship to bacteriuria in spinal cord injured patients on intermittent catheterization. (2719541)
1989
47
Detection of bacteriuria and pyuria within two minutes. (3886693)
1985
48
Urinary tract infection during pregnancy. Asymptomatic bacteriuria, acute cystitis, and acute pyelonephritis. (6374641)
1984
49
Prevalence of symptomless urinary tract disease in Birmingham schoolchildren. I. Pyuria and bacteriuria. (5790270)
1969
50
THE QUANTITATIVE EVALUATION OF BACTERIURIA AND PYURIA. (14206767)
1964

Genetic Variations for Bacteriuria

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Expression for genes affiliated with Bacteriuria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bacteriuria

Search GEO for disease gene expression data for Bacteriuria.

Pathways for genes affiliated with Bacteriuria

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Sources:
52R&D Systems, 12EMD Millipore, 29KEGG, 4Cell Signaling Technology, 59Tocris Bioscience, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 55SinoBiological
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Pathways related to Bacteriuria according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1TLR1, TLR5
2
Cell adhesion ECM remodeling
Hide members
10.0ADAM8
310.0TLR2, TLR4
410.0TLR2, TLR4
5
Mucin expression in CF via IL-6, IL-17 signaling pathways
9.8TIRAP, TLR2, TLR5
69.8TLR1, TLR2, TLR4
79.7TIRAP, TLR4, IL8
89.7TLR4, TLR5, IL8
99.6TIRAP, TLR4, TLR2, TLR1
109.6TLR4, TLR2, TLR5, TLR1
11
Hide members
9.6TLR1, TLR5, TLR2, TLR4
129.6TLR4, TLR2, TLR5, TLR1
139.6TLR1, TLR5, TLR2, TLR4
14
Hide members
9.6TLR4, TLR2, TLR5, TLR1
15
Hide members
9.5TLR4, TLR2, TLR5, CD40LG
169.5IL8, CD40LG, TLR4, TIRAP
179.4TLR4, TLR2, TLR5, IL8
189.4IL8, CXCR1, CXCR2
19
Hide members
9.4TIRAP, TLR4, TLR2, TLR5, TLR1
20
Hide members
9.4TIRAP, TLR4, TLR2, TLR5, TLR1
21
Hide members
9.3TLR4, TLR2, TLR5, TLR1, CD40LG
22
Hide members
9.3TLR4, TLR2, TLR5, TLR1, CD79A
239.1IL8, TLR1, TLR5, TLR2, TLR4, TIRAP
24
Immune response Bacterial infections in normal airways
9.1TIRAP, TLR4, TLR2, TLR5, TLR1, IL8
25
Hide members
9.1TIRAP, TLR4, TLR2, TLR5, TLR1, IL8
26
Hide members
9.1TIRAP, TLR4, TLR2, TLR5, TLR1, IL8
27
Hide members
9.1TIRAP, TLR4, TLR2, TLR5, TLR1, IL8
28
Hide members
8.8TIRAP, TLR4, TLR2, TLR5, TLR1, CD40LG

Compounds for genes affiliated with Bacteriuria

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44Novoseek, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Bacteriuria according to GeneCards/GeneDecks:

(show top 50)    (show all 94)
idCompoundScoreTop Affiliating Genes
1gamma globulin4410.5CRP
2endotoxin4410.4CXCR2
3cycloheximide4410.4CAT, TLR2
4pam3csk45910.2TLR2, TLR4, TLR1
5pam2csk45910.2TLR1, TLR2, TLR4
6poly(i:c)5910.2TLR4, TLR2, TLR1
7resiquimod44 5911.2TLR4, TLR2, TLR1
8superoxide44 2411.2PRF1, CXCR2
9loxoribine44 2811.2TLR4, TLR2, TLR5
10sulfolipid i4410.2CD40LG, CD79A
11glucuronoxylomannan4410.1CD40LG, TLR2, TLR4
12muramyl dipeptide44 2811.0TLR4, TLR2, IL8
13pneumococcal4410.0TLR4, CD40LG, CD79A
14hbd24410.0TLR4, TLR2, IL8
15cxcl1289.9CXCR2, CXCR1
16bucillamine449.9CAT, CRP, CD79A
17cxcl6289.9CXCR2, CXCR1
18imiquimod44 28 59 1112.9IL8, TLR1, TLR2, TLR4
19polymyxin b449.9TLR2, IL8
20cxcl8289.9CXCR2, CXCR1
21[125i]cxcl8 (human)289.9CXCR2, CXCR1
22mannan449.9TLR4, TLR2, CD40LG, CD79A
23pmma449.9CD79A, CD40LG, CRP
24azithromycin44 1110.8CRP, CD79A, IL8
25poly(i-c)449.8TLR4, TLR2, TLR5, IL8
26enterotoxin449.8CD79A, PRF1, TLR2
27anti-fungal449.8TLR4, TLR2, CD40LG, CD79A
28grogamma449.8CXCR2, CXCR1, IL8
29ccl344 2810.8TLR4, TLR2, CXCR1, IL8
30grobeta449.8CXCR2, CXCR1, IL8
31flagellin44 2810.7IL8, TLR1, TLR5, TLR2, TLR4
32rantes449.7CXCR1, CD40LG, TLR5, TLR2, TLR4
33peptidoglycan44 2810.7TLR4, TLR2, TLR5, TLR1, IL8
34sulfasalazine44 28 49 1112.7CRP, CD40LG, CD79A, IL8
35neopterin449.6IL8, CD79A, CD40LG, CRP
36okt3449.6CRP, CD40LG, CD79A
37allergens449.5TLR4, CD40LG, CD79A, ADAM8
38leukotriene b444 59 2411.4TLR2, CXCR2, CXCR1, IL8
39polysaccharide449.4TLR4, TLR2, UMOD, CD40LG, CD79A
40sb 20358044 5910.3CAT, TLR4, TLR2, CRP, IL8
41actinomycin d449.2CAT, TLR4, TLR2, CD40LG, CXCR1, IL8
42lipoteichoic acid449.2IL8, TLR4, TLR2, TLR5, TLR1, CXCR2
43n acetylcysteine449.1CAT, TLR4, CRP, CD40LG, CD79A, IL8
44groalpha449.1CXCR1, IL8, CXCR2
45lactate449.0CAT, TLR4, CRP, CD40LG, CD79A, IL8
46histamine44 28 2411.0IL8, CD79A, CD40LG, TLR2, TLR4
47fibrinogen449.0TLR4, TLR2, CRP, CD40LG, CD79A, CXCR2
48alanine448.7TLR4, TLR2, CRP, CD40LG, CD79A, CXCR2
49vegf448.4TLR4, TLR2, CRP, CD40LG, CD79A, CXCR2
50cysteine448.3CAT, TLR4, TLR2, UMOD, CD40LG, CD79A

GO Terms for genes affiliated with Bacteriuria

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Sources:
16Gene Ontology
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Cellular components related to Bacteriuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:0353549.9TLR1, TLR2
2external side of plasma membraneGO:0098979.4CD79A, CD40LG, TLR2, TLR4
3integral to plasma membraneGO:0058877.8TLR4, TLR2, TLR1, CD40LG, PCDH8, CXCR2
4plasma membraneGO:0058866.4ADAM8, TIRAP, CAT, TLR4, TLR2, TLR5

Biological processes related to Bacteriuria according to GeneCards/GeneDecks:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cellular response to triacyl bacterial lipopeptideGO:07172710.4TLR2, TLR1
2detection of triacyl bacterial lipopeptideGO:04249510.4TLR2, TLR1
3positive regulation of interleukin-6 biosynthetic processGO:04541010.4TIRAP, TLR1
4detection of diacyl bacterial lipopeptideGO:04249610.4TLR2, TLR1
5cellular response to bacterial lipopeptideGO:07122110.4TIRAP, TLR2
6regulation of cytokine secretionGO:05070710.3TLR4, TLR1
7positive regulation of toll-like receptor signaling pathwayGO:03412310.3TLR5, TLR2
8macrophage activationGO:04211610.3TLR1, TLR4
9positive regulation of macrophage cytokine productionGO:06090710.3TLR4, TLR2
10negative regulation of interleukin-17 productionGO:03270010.2TLR2, TLR4
11positive regulation of tumor necrosis factor biosynthetic processGO:04253510.2TLR4, TLR2, TLR1
12cellular response to lipoteichoic acidGO:07122310.2TLR2, TLR4, TIRAP
13positive regulation of tumor necrosis factor productionGO:03276010.1TIRAP, TLR4, TLR2
14I-kappaB phosphorylationGO:00725210.1TLR2, TLR4
15positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.1TLR2, TLR4
16interleukin-8-mediated signaling pathwayGO:03811210.1CXCR2, CXCR1
17defense response to Gram-positive bacteriumGO:05083010.0TIRAP, TLR2, CRP
18toll-like receptor TLR6:TLR2 signaling pathwayGO:03812410.0TIRAP, TLR4, TLR2
19toll-like receptor TLR1:TLR2 signaling pathwayGO:03812310.0TIRAP, TLR4, TLR2
20B cell proliferationGO:04210010.0CD40LG, CD79A
21toll-like receptor 2 signaling pathwayGO:03413410.0TLR2, TLR4, TIRAP
22positive regulation of interleukin-8 productionGO:03275710.0TIRAP, TLR4, TLR2, TLR5
23T-helper 1 type immune responseGO:04208810.0TLR1, TLR4
24toll-like receptor signaling pathwayGO:0022249.9TLR5, TLR2, TLR4, TIRAP
25positive regulation of interleukin-12 productionGO:0327359.9CD40LG, TLR2, TLR4, TIRAP
26cellular defense responseGO:0069689.9CXCR2, PRF1, UMOD
27neutrophil activationGO:0421199.8CXCR2, IL8
28toll-like receptor 4 signaling pathwayGO:0341429.8TLR2, TLR4, TIRAP
29MyD88-dependent toll-like receptor signaling pathwayGO:0027559.8TIRAP, TLR4, TLR2, TLR5, TLR1
30receptor internalizationGO:0316239.8IL8, CXCR1, CXCR2
31dendritic cell chemotaxisGO:0024079.4CXCR2, CXCR1
32positive regulation of NF-kappaB transcription factor activityGO:0510929.4TIRAP, CAT, TLR4, TLR2, ADAM8
33innate immune responseGO:0450879.4TLR1, TLR5, TLR2, TLR4, TIRAP
34inflammatory responseGO:0069547.9ADAM8, TIRAP, TLR2, TLR5, TLR1, CRP

Molecular functions related to Bacteriuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00187510.0TLR2, TLR4
2interleukin-8 receptor activityGO:0049189.6CXCR2, CXCR1
3transmembrane signaling receptor activityGO:0048889.5CD79A, TLR1, TLR2, TLR4
4interleukin-8 bindingGO:0199599.4CXCR1, CXCR2

Products for genes affiliated with Bacteriuria

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bacteriuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet