MCID: BGS001
MIFTS: 48

Bagassosis malady

Respiratory diseases category

Summaries for Bagassosis

About this section
Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Disease Ontology:9 An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

MalaCards: Bagassosis, also known as sugar cane worker pneumonitis, is related to pulmonary function and silicosis. An important gene associated with Bagassosis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Cellular roles of Anthrax toxin and LDL Oxidation in Atherogenesis. The compounds rantes and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and liver, and related mouse phenotypes are tumorigenesis and immune system.

Wikipedia:66 Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to... more...

Aliases & Classifications for Bagassosis

About this section
Sources:
9Disease Ontology, 63UMLS, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

bagassosis 9 63
sugar cane worker pneumonitis 9


External Ids:

Disease Ontology9 DOID:12522
NCIt41 C34409
ICD9CM28 495.1
SNOMED-CT59 67242002
MeSH36 D011009
ICD1026 J67.1

Related Diseases for Bagassosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Bagassosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary function10.4
2silicosis10.2
3degenerative disc disease10.1IL1B
4malaria10.1TNF
5muckle-wells syndrome10.1IL1B
6sinusitis10.1IL5
7leishmaniasis10.1IL5
8crohn's disease10.1TNF
9blau syndrome10.0IL1B, TNF
10aids dementia complex10.0IL1B, TNF
11familial mediterranean fever10.0IL1B, TNF
12pulmonary eosinophilia10.0IL5, IL8
13interstitial lung disease10.0IL1B, TNF
14psoriatic arthritis10.0TNF, IL1B
15cerebral malaria10.0TNF, IL1B
16toxic shock syndrome10.0IL1B, TNF
17vernal keratoconjunctivitis10.0IL5, IL8
18bronchitis10.0IL5, IL8
19byssinosis10.0
20extrinsic allergic alveolitis10.0
21lung cancer10.0
22bacterial vaginosis10.0IL1B, IL8
23bronchiolitis10.0IL8, IL5
24adult respiratory distress syndrome10.0IL8, TNF
25bacterial meningitis10.0IL8, IL1B
26alcoholic hepatitis10.0TNF, IL8
27mastitis10.0IL8, IL1B
28periodontitis10.0IL8, IL1B
29rhinitis10.0IL8, IL5
30arthropathy10.0TNF, IL1B
31behcet's disease10.0IL8, TNF
32periodontal disease10.0TNF, IL6
33euthyroid sick syndrome10.0IL6, IL1B
34poems syndrome10.0IL6, IL1B
35pulmonary disease, chronic obstructive10.0IL6, IL1B
36eosinophilia10.0IL8, IL5
37idiopathic pulmonary fibrosis10.0IL1B, IL8
38gastritis10.0IL8, IL1B
39eye disease10.0IL6, IL1B
40viral meningitis10.0IL8, IL6
41allergic rhinitis10.0IL8, IL5
42juvenile rheumatoid arthritis10.0IL6, TNF
43thrombocytosis10.0IL6, IL1B
44acquired immunodeficiency syndrome10.0IL1B, IL6
45allergic asthma10.0IL8, IL5
46connective tissue disease10.0TNF, IL6
47prion disease10.0IL1B, IL6
48atopic dermatitis10.0IL8, TNF, IL5
49skin disease10.0IL8, TNF, IL5
50acute pancreatitis10.0IL6, IL8

Graphical network of the top 20 diseases related to Bagassosis:



Diseases related to bagassosis

Symptoms for Bagassosis

About this section

Drugs & Therapeutics for Bagassosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Bagassosis

Drug clinical trials:

Search ClinicalTrials for Bagassosis

Search NIH Clinical Center for Bagassosis

Search CenterWatch for Bagassosis

Genetic Tests for Bagassosis

About this section

Anatomical Context for Bagassosis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Bagassosis:

34
Lung, Skin, Liver

Animal Models for Bagassosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Bagassosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9TNF, IL5, IL6, IL1B
2MP:00053877.5IL1B, IL6, IL8, IL5, TNF
3MP:00053977.4IL1B, IL6, IL8, IL5, TNF

Publications for Bagassosis

About this section
Sources:
53PubMed
See all sources

Articles related to Bagassosis:

(show all 43)
idTitleAuthorsYear
1
Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. (15376226)
2004
2
Hypersensitivity pneumonitis: bagassosis. (7807612)
1994
3
Recent trends in bagassosis in Japan. (1637710)
1992
4
Clinical, epidemiological, and laboratory criteria for the diagnosis of bagassosis. (2305800)
1990
5
Experimental bagassosis: role of infection. (6884291)
1983
6
Pathophysiological disturbances in bagassosis and bagasse workers. (7116010)
1982
7
Elimination of bagassosis in Louisiana paper manufacturing plant workers. (627039)
1978
8
Bagassosis: a report of 8 cases. (4424270)
1974
9
Bagassosis: a histopathologic study of pulmonary biopsies from six cases. (4712724)
1973
10
Pulmonary function at rest and during exercise following bagassosis. (4995433)
1971
11
Sequential observations on pulmonary functional derangements in Bagassosis. (5111660)
1971
12
Thermoactinomyces sacchari sp. nov., a thermophilic actinomycete causing bagassosis. (4999215)
1971
13
Prevention of bagassosis by addition of propionic acid to sugar cane waste. (5201841)
1970
14
Bagassosis. (A case report). (5456139)
1970
15
Bagassosis. IV. Precipitins against extracts of thermophilic actinomycetes in patients with bagassosis. (4182997)
1969
16
Bagassosis: an epidemiological, environmental, and clinical survey. (5723350)
1968
17
Bagassosis. (4170904)
1968
18
Pulmonary function in bagassosis. (5673109)
1968
19
Immunological aspects of bagassosis. (4972748)
1968
20
Bagassosis. (5609030)
1967
21
Bagassosis II. Skin reactivity to crude bagasse extracts and atopic status of patients. (4960059)
1967
22
Bagassosis: a study of pulmonary function in 20 cases. (23841194)
1966
23
Bagassosis: I. Precipitins against extracts of crude bagasse in the serum of patients. (23841195)
1966
24
THE RESURGENCE OF BAGASSOSIS IN LOUISIANA. (14218625)
1964
25
Bagassosis. (13997509)
1963
26
Glycogen metabolism of guinea-pig in experimental bagassosis. (13913344)
1962
27
Bagassosis and silicosis in the Philippines. (14028138)
1962
28
Bagassosis: a true pnemoconiosis. (13874417)
1962
29
Metastasizing lung cancer associated with past bagassosis. (13940182)
1962
30
In vitro studies on the utilization of glucose-1-14C by guinea-pig lungs in experimental bagassosis. (13977669)
1962
31
A study of tissue respiration & respiratory enzymes of guinea-pig liver in experimental bagassosis. (14039305)
1962
32
Cellular constituents of guinea-pig lungs in experimental bagassosis. (13913343)
1962
33
Experimental bagassosis. I. Enzymes of the lung in vivo. (14447107)
1960
34
Bagassosis-a medical enigma. (13805673)
1960
35
Experimental bagassosis. II. Enzymes of lung in vitro. (14447108)
1960
36
Bagassosis; a review, with further historical data, studies of pulmonary function, and results of adrenal steroid therapy. (13559276)
1958
37
Early bagassosis. (13233534)
1955
38
Bagassosis. (13263628)
1955
39
Aerobacter cloacae endotoxin as a possible factor in the etiology of bagassosis. (18873565)
1948
40
Aerobacter cloacae as a possible factor in the etiology of bagassosis. (20987049)
1946
41
Byssinosis and Bagassosis. (20784632)
1943
42
Four Cases of Bagassosis. (20784538)
1942
43
Bagassosis: An Industrial Lung Disease. (20784500)
1942

Variations for Bagassosis

About this section

Expression for genes affiliated with Bagassosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Bagassosis

Search GEO for disease gene expression data for Bagassosis.

Pathways for genes affiliated with Bagassosis

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 31KEGG, 55R&D Systems, 56Reactome, 61Thomson Reuters, 13EMD Millipore
See all sources

Pathways related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TNF, IL1B
29.4TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity39
9.4TNF, IL1B
49.3TNF, IL8
59.1IL6, IL1B
69.0IL8, IL6
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.9TNF, IL8, IL5
88.8TNF, IL1B, IL8
98.7IL5, IL6, IL1B
10
Show member pathways
8.7IL1B, IL6, IL5
11
Show member pathways
8.7IL6, IL1B, IL5
128.6IL1B, IL6, TNF
138.6TNF, IL6, IL1B
148.6IL1B, IL6, TNF
158.6IL1B, IL6, TNF
16
Show member pathways
thioredoxin pathway39
8.6IL1B, IL6, TNF
17
Show member pathways
IL27-mediated signaling events39
8.6TNF, IL6, IL1B
188.6TNF, IL6, IL1B
19
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
8.6IL6, TNF, IL1B
20
Show member pathways
8.6IL6, TNF, IL1B
218.6IL6, IL5, IL8
22
Show member pathways
8.5IL1B, IL6, IL8
238.5IL1B, IL6, IL8
248.5IL8, IL6, TNF
258.2IL5, IL6, TNF, IL1B
268.2TNF, IL1B, IL5, IL6
27
Show member pathways
8.2IL6, TNF, IL5, IL1B
28
Show member pathways
8.2IL6, TNF, IL5, IL1B
29
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.2IL1B, IL6, TNF, IL5
308.1IL8, IL6, IL1B, IL5
318.0TNF, IL8, IL6, IL1B
32
Show member pathways
8.0TNF, IL8, IL6, IL1B
33
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.0IL6, TNF, IL8, IL1B
34
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.0IL1B, IL6, IL8, TNF
35
Show member pathways
8.0IL1B, IL6, IL8, TNF
368.0IL1B, IL6, IL8, TNF
378.0IL6, IL8, TNF, IL1B
388.0TNF, IL6, IL1B, IL8
398.0TNF, IL6, IL8, IL1B
40
Show member pathways
8.0IL1B, IL6, TNF, IL8
418.0IL6, IL8, TNF, IL1B
428.0IL1B, IL6, TNF, IL8
43
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.0IL1B, IL6, IL8, TNF
44
Show member pathways
Immune response MIF in innate immunity response61
8.0IL8, IL6, TNF, IL1B
45
Show member pathways
7.5IL1B, IL5, IL8, IL6, TNF
46
Show member pathways
7.5IL5, IL8, TNF, IL6, IL1B
477.5IL6, IL8, IL5, IL1B, TNF
48
Show member pathways
7.5IL5, TNF, IL1B, IL8, IL6
49
Show member pathways
7.5TNF, IL1B, IL6, IL8, IL5
50
Show member pathways
7.5IL6, IL1B, TNF, IL8, IL5

Compounds for genes affiliated with Bagassosis

About this section
Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1rantes469.3IL5, IL1B, IL8
2toxin-1468.9TNF, IL8, IL1B
3tenidap46 309.9IL1B, TNF, IL6
4anakinra46 129.9IL6, IL1B, TNF
5gold sodium thiomalate468.9TNF, IL8, IL1B
6vesnarinone468.9TNF, IL6, IL1B
7mcp 1468.8IL5, IL8, IL6
8budesonide46 52 1210.8IL1B, TNF, IL5, IL8
9fluticasone propionate46 52 62 1211.8IL1B, IL5, TNF, IL8
10gabexate mesilate468.7IL8, IL6, TNF
11ulinastatin468.7TNF, IL6, IL8
12hbd2468.7IL1B, IL8, IL6
13ivig468.5IL6, TNF, IL5, IL1B
14imiquimod46 62 30 1211.5IL5, IL8, IL6, TNF
15thalidomide46 52 62 1211.5IL1B, TNF, IL5, IL6
16taurine chloramine468.4IL8, IL1B, IL6, TNF
17mip 1alpha468.4IL1B, TNF, IL6, IL8
18tpck468.4TNF, IL8, IL1B, IL6
19polymyxin b468.4IL8, IL6, IL1B, TNF
20groalpha468.4TNF, IL8, IL6, IL1B
21triptolide468.4IL1B, IL6, IL8, TNF
22ciglitazone46 309.4TNF, IL8, IL6, IL1B
23lipoteichoic acid468.4IL1B, IL8, TNF, IL6
24etanercept46 52 1210.4TNF, IL1B, IL6, IL8
25peptidoglycan46 309.4IL8, TNF, IL1B, IL6
26pentoxifylline46 129.4TNF, IL8, IL6, IL1B
27fmlp468.4IL1B, IL8, TNF, IL5
28ccl346 309.3IL6, IL1B, IL8, TNF
29neopterin468.3IL1B, IL6, IL8, TNF
3015-deoxy-delta-12,14-prostaglandin j2468.3IL8, IL6, IL1B, TNF
31pdtc468.3IL8, TNF, IL6, IL1B
32sp 60012546 629.3IL1B, IL6, IL8, TNF
33troglitazone46 30 62 1211.2IL6, IL1B, IL8, TNF
34endotoxin468.0IL8, TNF, IL6, IL1B
35il-12468.0TNF, IL1B, IL6, IL8, IL5
36gm-csf46 309.0IL1B, IL5, IL8, TNF, IL6
37polyinosinic-polycytidylic acid468.0IL8, IL1B, IL6, IL5, TNF
38poly(i-c)468.0TNF, IL5, IL8, IL6, IL1B
39il 10468.0TNF, IL5, IL1B, IL6, IL8
40leukotriene b446 62 2510.0IL1B, IL6, IL8, IL5, TNF
41hydrocortisone46 3 62 1211.0IL6, IL1B, IL5, TNF, IL8
42herbimycin a46 629.0TNF, IL5, IL8, IL6, IL1B
43sb 20358046 628.9IL5, IL1B, IL6, IL8, TNF
44histamine46 30 259.9IL8, IL5, IL6, IL1B, TNF
45ly294002467.9IL8, TNF, IL5, IL1B, IL6
46genistein46 30 62 3 25 1212.9IL1B, IL6, IL5, TNF, IL8
47pge2467.9TNF, IL5, IL8, IL6, IL1B
48cycloheximide467.8IL6, IL1B, IL8, IL5, TNF
49curcumin467.7IL1B, TNF, IL8, IL6
50dexamethasone46 52 30 1210.4TNF, IL5, IL8, IL6, IL1B

GO Terms for genes affiliated with Bagassosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL5, IL8, IL6, IL1B, TNF
2extracellular spaceGO:0056157.2IL1B, IL6, IL8, IL5, TNF

Biological processes related to Bagassosis according to GeneCards/GeneDecks:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:0718039.9TNF, IL5
2sequestering of triglycerideGO:0307309.9IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:0341169.9TNF, IL1B
5positive regulation of fever generationGO:0316229.9TNF, IL1B
6positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL1B
7regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.8IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IL1B, TNF
9negative regulation of lipid catabolic processGO:0509959.8TNF, IL1B
10positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL1B, TNF
12positive regulation of mitosisGO:0458409.8IL1B, TNF
13protein kinase B signalingGO:0434919.8IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15cellular response to organic cyclic compoundGO:0714079.8TNF, IL1B
16positive regulation of interferon-gamma productionGO:0327299.8IL1B, TNF
17embryonic digestive tract developmentGO:0485669.7IL8, TNF
18positive regulation of JNK cascadeGO:0463309.7IL1B, TNF
19neutrophil chemotaxisGO:0305939.6IL8, IL1B
20calcium-mediated signalingGO:0197229.6IL8, TNF
21MAPK cascadeGO:0001659.6IL1B, TNF
22positive regulation of immunoglobulin secretionGO:0510249.6IL5, IL6
23positive regulation of JAK-STAT cascadeGO:0464279.6IL5, IL6
24epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.6TNF, IL6
25negative regulation of lipid storageGO:0108889.5TNF, IL6
26positive regulation of chemokine productionGO:0327229.5IL6, TNF
27regulation of insulin secretionGO:0507969.5IL1B, TNF
28defense response to Gram-positive bacteriumGO:0508309.5TNF, IL6
29negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
30positive regulation of protein phosphorylationGO:0019349.4IL1B, TNF
31positive regulation of smooth muscle cell proliferationGO:0486619.4IL6, TNF
32positive regulation of T cell proliferationGO:0421029.4IL6, IL1B
33positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, TNF
34response to mechanical stimulusGO:0096129.4IL6, TNF
35positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, IL5
36humoral immune responseGO:0069599.4TNF, IL6
37activation of MAPK activityGO:0001879.3IL1B, TNF
38positive regulation of protein kinase B signalingGO:0518979.3TNF, IL6
39response to glucocorticoidGO:0513849.2IL6, TNF
40immune responseGO:0069559.2IL5, IL8, IL1B
41cytokine-mediated signaling pathwayGO:0192219.1IL5, IL6, IL1B
42positive regulation of nitric oxide biosynthetic processGO:0454299.1IL1B, IL6, TNF
43positive regulation of interleukin-6 productionGO:0327559.1TNF, IL6, IL1B
44positive regulation of NF-kappaB transcription factor activityGO:0510929.0IL1B, IL6, TNF
45positive regulation of ERK1 and ERK2 cascadeGO:0703748.8IL6, TNF
46positive regulation of transcription from RNA polymerase II promoterGO:0459448.6TNF, IL6, IL1B
47positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.6TNF, IL5, IL6, IL1B
48positive regulation of transcription, DNA-templatedGO:0458938.6TNF, IL5, IL6, IL1B
49negative regulation of cell proliferationGO:0082858.4TNF, IL8, IL6, IL1B
50inflammatory responseGO:0069548.0IL1B, IL6, IL8, IL5, TNF

Molecular functions related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.2IL1B, IL6, IL5, TNF

Products for genes affiliated with Bagassosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bagassosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet