MCID: BGS001
MIFTS: 48

Bagassosis malady

Respiratory diseases category

Summaries for Bagassosis

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Disease Ontology:9 An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

MalaCards based summary: Bagassosis, also known as sugar cane worker pneumonitis, is related to degenerative disc disease and malaria. An important gene associated with Bagassosis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Cellular roles of Anthrax toxin and LDL Oxidation in Atherogenesis. The compounds rantes and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and skin, and related mouse phenotypes are tumorigenesis and immune system.

Wikipedia:64 Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to... more...

Aliases & Classifications for Bagassosis

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Bagassosis, Aliases & Descriptions:

Name: Bagassosis 9 61
 
Sugar Cane Worker Pneumonitis 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


External Ids:

Disease Ontology9 DOID:12522
NCIt39 C34409
ICD9CM28 495.1
SNOMED-CT56 67242002
MeSH34 D011009
ICD1026 J67.1

Related Diseases for Bagassosis

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Diseases related to Bagassosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1degenerative disc disease10.5IL1B
2malaria10.4TNF
3muckle-wells syndrome10.4IL1B
4sinusitis10.4IL5
5leishmaniasis10.4IL5
6pulmonary function10.4
7crohn's disease10.4TNF
8silicosis10.2
9blau syndrome10.2TNF, IL1B
10aids dementia complex10.2TNF, IL1B
11familial mediterranean fever10.2TNF, IL1B
12pulmonary eosinophilia10.2IL5, IL8
13interstitial lung disease10.2TNF, IL1B
14psoriatic arthritis10.2IL1B, TNF
15cerebral malaria10.2IL1B, TNF
16vernal keratoconjunctivitis10.2IL5, IL8
17toxic shock syndrome10.2IL1B, TNF
18bronchitis10.2IL8, IL5
19bacterial vaginosis10.2IL8, IL1B
20bronchiolitis10.1IL5, IL8
21adult respiratory distress syndrome10.1TNF, IL8
22bacterial meningitis10.1IL1B, IL8
23alcoholic hepatitis10.1TNF, IL8
24mastitis10.1IL1B, IL8
25periodontitis10.1IL1B, IL8
26rhinitis10.1IL5, IL8
27arthropathy10.1IL1B, TNF
28behcet's disease10.1IL8, TNF
29periodontal disease10.1IL6, TNF
30euthyroid sick syndrome10.1IL1B, IL6
31poems syndrome10.1IL1B, IL6
32chronic obstructive pulmonary disease10.1IL6, IL1B
33byssinosis10.1
34lung cancer10.1
35eosinophilia10.0IL8, IL5
36idiopathic pulmonary fibrosis10.0IL8, IL1B
37gastritis10.0IL1B, IL8
38spiradenoma10.0IL1B, IL6
39viral meningitis10.0IL6, IL8
40allergic rhinitis10.0IL8, IL5
41juvenile rheumatoid arthritis10.0TNF, IL6
42thrombocytosis10.0IL1B, IL6
43acquired immunodeficiency syndrome10.0IL6, IL1B
44allergic asthma10.0IL8, IL5
45connective tissue disease10.0TNF, IL6
46prion disease10.0IL1B, IL6
47atopic dermatitis10.0TNF, IL5, IL8
48skin disease10.0TNF, IL5, IL8
49pulmonary fibrosis9.9IL1B, IL8
50acute pancreatitis9.9IL6, IL8

Graphical network of the top 20 diseases related to Bagassosis:



Diseases related to bagassosis

Symptoms for Bagassosis

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Drugs & Therapeutics for Bagassosis

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Drug clinical trials:

Search ClinicalTrials for Bagassosis

Search NIH Clinical Center for Bagassosis

Genetic Tests for Bagassosis

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Anatomical Context for Bagassosis

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MalaCards organs/tissues related to Bagassosis:

32
Lung, Liver, Skin

Animal Models for Bagassosis or affiliated genes

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MGI Mouse Phenotypes related to Bagassosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9TNF, IL5, IL6, IL1B
2MP:00053877.5IL1B, IL6, IL8, IL5, TNF
3MP:00053977.4IL1B, IL6, IL8, IL5, TNF

Publications for Bagassosis

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Articles related to Bagassosis:

(show all 44)
idTitleAuthorsYear
1
Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. (15376226)
2004
2
Hypersensitivity pneumonitis: bagassosis. (7807612)
1994
3
Recent trends in bagassosis in Japan. (1637710)
1992
4
Clinical, epidemiological, and laboratory criteria for the diagnosis of bagassosis. (2305800)
1990
5
Experimental bagassosis: role of infection. (6884291)
1983
6
Pathophysiological disturbances in bagassosis and bagasse workers. (7116010)
1982
7
Elimination of bagassosis in Louisiana paper manufacturing plant workers. (627039)
1978
8
Bagassosis: a report of 8 cases. (4424270)
1974
9
Bagassosis: a histopathologic study of pulmonary biopsies from six cases. (4712724)
1973
10
Pulmonary function at rest and during exercise following bagassosis. (4995433)
1971
11
Sequential observations on pulmonary functional derangements in Bagassosis. (5111660)
1971
12
Thermoactinomyces sacchari sp. nov., a thermophilic actinomycete causing bagassosis. (4999215)
1971
13
Prevention of bagassosis by addition of propionic acid to sugar cane waste. (5201841)
1970
14
Bagassosis. (A case report). (5456139)
1970
15
Bagassosis. IV. Precipitins against extracts of thermophilic actinomycetes in patients with bagassosis. (4182997)
1969
16
Bagassosis: an epidemiological, environmental, and clinical survey. (5723350)
1968
17
Bagassosis. (4170904)
1968
18
Pulmonary function in bagassosis. (5673109)
1968
19
Immunological aspects of bagassosis. (4972748)
1968
20
Bagassosis. (5609030)
1967
21
Bagassosis II. Skin reactivity to crude bagasse extracts and atopic status of patients. (4960059)
1967
22
Bagassosis: a study of pulmonary function in 20 cases. (23841194)
1966
23
Bagassosis: I. Precipitins against extracts of crude bagasse in the serum of patients. (23841195)
1966
24
THE RESURGENCE OF BAGASSOSIS IN LOUISIANA. (14218625)
1964
25
Bagassosis. (13997509)
1963
26
Glycogen metabolism of guinea-pig in experimental bagassosis. (13913344)
1962
27
Bagassosis and silicosis in the Philippines. (14028138)
1962
28
Bagassosis: a true pnemoconiosis. (13874417)
1962
29
Metastasizing lung cancer associated with past bagassosis. (13940182)
1962
30
In vitro studies on the utilization of glucose-1-14C by guinea-pig lungs in experimental bagassosis. (13977669)
1962
31
A study of tissue respiration & respiratory enzymes of guinea-pig liver in experimental bagassosis. (14039305)
1962
32
Cellular constituents of guinea-pig lungs in experimental bagassosis. (13913343)
1962
33
The glycolytic enzymes of guinea-pig lung in experimental bagassosis. (16748890)
1961
34
Experimental bagassosis. I. Enzymes of the lung in vivo. (14447107)
1960
35
Bagassosis-a medical enigma. (13805673)
1960
36
Experimental bagassosis. II. Enzymes of lung in vitro. (14447108)
1960
37
Bagassosis; a review, with further historical data, studies of pulmonary function, and results of adrenal steroid therapy. (13559276)
1958
38
Early bagassosis. (13233534)
1955
39
Bagassosis. (13263628)
1955
40
Aerobacter cloacae endotoxin as a possible factor in the etiology of bagassosis. (18873565)
1948
41
Aerobacter cloacae as a possible factor in the etiology of bagassosis. (20987049)
1946
42
Byssinosis and Bagassosis. (20784632)
1943
43
Four Cases of Bagassosis. (20784538)
1942
44
Bagassosis: An Industrial Lung Disease. (20784500)
1942

Variations for Bagassosis

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Expression for genes affiliated with Bagassosis

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Expression patterns in normal tissues for genes affiliated with Bagassosis

Search GEO for disease gene expression data for Bagassosis.

Pathways for genes affiliated with Bagassosis

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Pathways related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TNF, IL1B
29.4TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity37
9.4TNF, IL1B
49.3TNF, IL8
59.1IL6, IL1B
69.0IL8, IL6
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.9TNF, IL8, IL5
88.8TNF, IL1B, IL8
98.7IL5, IL6, IL1B
10
Show member pathways
8.7IL1B, IL6, IL5
11
Show member pathways
8.7IL6, IL1B, IL5
128.6IL1B, IL6, TNF
138.6TNF, IL6, IL1B
148.6IL1B, IL6, TNF
158.6IL1B, IL6, TNF
16
Show member pathways
thioredoxin pathway37
8.6IL1B, IL6, TNF
17
Show member pathways
IL27-mediated signaling events37
8.6TNF, IL6, IL1B
188.6TNF, IL6, IL1B
19
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
8.6IL6, TNF, IL1B
20
Show member pathways
8.6IL6, TNF, IL1B
218.6IL6, IL5, IL8
22
Show member pathways
8.5IL1B, IL6, IL8
238.5IL1B, IL6, IL8
248.5IL8, IL6, TNF
258.2IL5, IL6, TNF, IL1B
268.2TNF, IL1B, IL5, IL6
27
Show member pathways
8.2IL6, TNF, IL5, IL1B
28
Show member pathways
8.2IL6, TNF, IL5, IL1B
29
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.2IL1B, IL6, TNF, IL5
308.1IL8, IL6, IL1B, IL5
318.0TNF, IL8, IL6, IL1B
32
Show member pathways
8.0TNF, IL8, IL6, IL1B
33
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.0IL6, TNF, IL8, IL1B
34
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.0IL1B, IL6, IL8, TNF
35
Show member pathways
8.0IL1B, IL6, IL8, TNF
368.0IL1B, IL6, IL8, TNF
378.0IL6, IL8, TNF, IL1B
388.0TNF, IL6, IL1B, IL8
398.0TNF, IL6, IL8, IL1B
40
Show member pathways
8.0IL1B, IL6, TNF, IL8
418.0IL6, IL8, TNF, IL1B
428.0IL1B, IL6, TNF, IL8
43
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
8.0IL1B, IL6, IL8, TNF
44
Show member pathways
Immune response MIF in innate immunity response59
8.0IL8, IL6, TNF, IL1B
45
Show member pathways
7.5IL1B, IL5, IL8, IL6, TNF
46
Show member pathways
7.5IL5, IL8, TNF, IL6, IL1B
477.5IL6, IL8, IL5, IL1B, TNF
48
Show member pathways
7.5IL5, TNF, IL1B, IL8, IL6
49
Show member pathways
7.5TNF, IL1B, IL6, IL8, IL5
50
Show member pathways
7.5IL6, IL1B, TNF, IL8, IL5

Compounds for genes affiliated with Bagassosis

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Compounds related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1rantes449.3IL5, IL1B, IL8
2toxin-1448.9TNF, IL8, IL1B
3tenidap44 299.9IL1B, TNF, IL6
4anakinra44 129.9IL6, IL1B, TNF
5gold sodium thiomalate448.9TNF, IL8, IL1B
6vesnarinone448.9TNF, IL6, IL1B
7mcp 1448.8IL5, IL8, IL6
8budesonide44 50 1210.8IL1B, TNF, IL5, IL8
9fluticasone propionate44 50 60 1211.8IL1B, IL5, TNF, IL8
10gabexate mesilate448.7IL8, IL6, TNF
11ulinastatin448.7TNF, IL6, IL8
12hbd2448.7IL1B, IL8, IL6
13ivig448.5IL6, TNF, IL5, IL1B
14imiquimod44 60 29 1211.5IL5, IL8, IL6, TNF
15thalidomide44 50 60 1211.5IL1B, TNF, IL5, IL6
16taurine chloramine448.4IL8, IL1B, IL6, TNF
17mip 1alpha448.4IL1B, TNF, IL6, IL8
18tpck448.4TNF, IL8, IL1B, IL6
19polymyxin b448.4IL8, IL6, IL1B, TNF
20groalpha448.4TNF, IL8, IL6, IL1B
21triptolide448.4IL1B, IL6, IL8, TNF
22ciglitazone44 299.4TNF, IL8, IL6, IL1B
23lipoteichoic acid448.4IL1B, IL8, TNF, IL6
24etanercept44 50 1210.4TNF, IL1B, IL6, IL8
25peptidoglycan44 299.4IL8, TNF, IL1B, IL6
26pentoxifylline44 129.4TNF, IL8, IL6, IL1B
27fmlp448.4IL1B, IL8, TNF, IL5
28ccl344 299.3IL6, IL1B, IL8, TNF
29neopterin448.3IL1B, IL6, IL8, TNF
3015-deoxy-delta-12,14-prostaglandin j2448.3IL8, IL6, IL1B, TNF
31pdtc448.3IL8, TNF, IL6, IL1B
32sp 60012544 609.3IL1B, IL6, IL8, TNF
33troglitazone44 29 60 1211.2IL6, IL1B, IL8, TNF
34endotoxin448.0IL8, TNF, IL6, IL1B
35il-12448.0TNF, IL1B, IL6, IL8, IL5
36gm-csf44 299.0IL1B, IL5, IL8, TNF, IL6
37polyinosinic-polycytidylic acid448.0IL8, IL1B, IL6, IL5, TNF
38poly(i-c)448.0TNF, IL5, IL8, IL6, IL1B
39il 10448.0TNF, IL5, IL1B, IL6, IL8
40leukotriene b444 60 2510.0IL1B, IL6, IL8, IL5, TNF
41hydrocortisone44 3 60 1211.0IL6, IL1B, IL5, TNF, IL8
42herbimycin a44 609.0TNF, IL5, IL8, IL6, IL1B
43sb 20358044 608.9IL5, IL1B, IL6, IL8, TNF
44histamine44 29 259.9IL8, IL5, IL6, IL1B, TNF
45ly294002447.9IL8, TNF, IL5, IL1B, IL6
46genistein44 29 60 3 25 1212.9IL1B, IL6, IL5, TNF, IL8
47pge2447.9TNF, IL5, IL8, IL6, IL1B
48cycloheximide447.8IL6, IL1B, IL8, IL5, TNF
49curcumin447.7IL1B, TNF, IL8, IL6
50dexamethasone44 50 29 1210.4TNF, IL5, IL8, IL6, IL1B

GO Terms for genes affiliated with Bagassosis

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Cellular components related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL5, IL8, IL6, IL1B, TNF
2extracellular spaceGO:0056157.2IL1B, IL6, IL8, IL5, TNF

Biological processes related to Bagassosis according to GeneCards/GeneDecks:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:0718039.9TNF, IL5
2sequestering of triglycerideGO:0307309.9IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:0341169.9TNF, IL1B
5positive regulation of fever generationGO:0316229.9TNF, IL1B
6positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL1B
7regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.8IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IL1B, TNF
9negative regulation of lipid catabolic processGO:0509959.8TNF, IL1B
10positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL1B, TNF
12positive regulation of mitosisGO:0458409.8IL1B, TNF
13protein kinase B signalingGO:0434919.8IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15cellular response to organic cyclic compoundGO:0714079.8TNF, IL1B
16positive regulation of interferon-gamma productionGO:0327299.8IL1B, TNF
17embryonic digestive tract developmentGO:0485669.7IL8, TNF
18positive regulation of JNK cascadeGO:0463309.7IL1B, TNF
19neutrophil chemotaxisGO:0305939.6IL8, IL1B
20calcium-mediated signalingGO:0197229.6IL8, TNF
21MAPK cascadeGO:0001659.6IL1B, TNF
22positive regulation of immunoglobulin secretionGO:0510249.6IL5, IL6
23positive regulation of JAK-STAT cascadeGO:0464279.6IL5, IL6
24epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.6TNF, IL6
25negative regulation of lipid storageGO:0108889.5TNF, IL6
26positive regulation of chemokine productionGO:0327229.5IL6, TNF
27regulation of insulin secretionGO:0507969.5IL1B, TNF
28defense response to Gram-positive bacteriumGO:0508309.5TNF, IL6
29negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
30positive regulation of protein phosphorylationGO:0019349.4IL1B, TNF
31positive regulation of smooth muscle cell proliferationGO:0486619.4IL6, TNF
32positive regulation of T cell proliferationGO:0421029.4IL6, IL1B
33positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, TNF
34response to mechanical stimulusGO:0096129.4IL6, TNF
35positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, IL5
36humoral immune responseGO:0069599.4TNF, IL6
37activation of MAPK activityGO:0001879.3IL1B, TNF
38positive regulation of protein kinase B signalingGO:0518979.3TNF, IL6
39response to glucocorticoidGO:0513849.2IL6, TNF
40immune responseGO:0069559.2IL5, IL8, IL1B
41cytokine-mediated signaling pathwayGO:0192219.1IL5, IL6, IL1B
42positive regulation of nitric oxide biosynthetic processGO:0454299.1IL1B, IL6, TNF
43positive regulation of interleukin-6 productionGO:0327559.1TNF, IL6, IL1B
44positive regulation of NF-kappaB transcription factor activityGO:0510929.0IL1B, IL6, TNF
45positive regulation of ERK1 and ERK2 cascadeGO:0703748.8IL6, TNF
46positive regulation of transcription from RNA polymerase II promoterGO:0459448.6TNF, IL6, IL1B
47positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.6TNF, IL5, IL6, IL1B
48positive regulation of transcription, DNA-templatedGO:0458938.6TNF, IL5, IL6, IL1B
49negative regulation of cell proliferationGO:0082858.4TNF, IL8, IL6, IL1B
50inflammatory responseGO:0069548.0IL1B, IL6, IL8, IL5, TNF

Molecular functions related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.2IL1B, IL6, IL5, TNF

Products for genes affiliated with Bagassosis

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Sources for Bagassosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
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47OMIM via Orphanet
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57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet