MCID: BGS001
MIFTS: 48

Bagassosis malady

Respiratory diseases category
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Summaries for Bagassosis

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

MalaCards: Bagassosis, also known as sugar cane worker pneumonitis, is related to pulmonary function and silicosis. An important gene associated with Bagassosis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Cellular roles of Anthrax toxin and LDL Oxidation in Atherogenesis. The compounds rantes and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and liver, and related mouse phenotypes are tumorigenesis and immune system.

Wikipedia:65 Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to... more...

Aliases & Classifications for Bagassosis

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

bagassosis 8 62
sugar cane worker pneumonitis 8


External Ids:

Disease Ontology8 DOID:12522
NCIt40 C34409
ICD9CM27 495.1
SNOMED-CT58 67242002
MeSH35 D011009
ICD1025 J67.1

Related Diseases for Bagassosis

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17GeneCards, 18GeneDecks
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Diseases related to Bagassosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary function10.4
2silicosis10.2
3degenerative disc disease10.1IL1B
4malaria10.1TNF
5muckle-wells syndrome10.1IL1B
6sinusitis10.1IL5
7leishmaniasis10.1IL5
8crohn's disease10.1TNF
9blau syndrome10.0IL1B, TNF
10aids dementia complex10.0IL1B, TNF
11familial mediterranean fever10.0IL1B, TNF
12pulmonary eosinophilia10.0IL5, IL8
13interstitial lung disease10.0IL1B, TNF
14psoriatic arthritis10.0TNF, IL1B
15cerebral malaria10.0TNF, IL1B
16toxic shock syndrome10.0IL1B, TNF
17vernal keratoconjunctivitis10.0IL5, IL8
18bronchitis10.0IL5, IL8
19byssinosis10.0
20extrinsic allergic alveolitis10.0
21lung cancer10.0
22bacterial vaginosis10.0IL1B, IL8
23bronchiolitis10.0IL8, IL5
24adult respiratory distress syndrome10.0IL8, TNF
25bacterial meningitis10.0IL8, IL1B
26alcoholic hepatitis10.0TNF, IL8
27mastitis10.0IL8, IL1B
28periodontitis10.0IL8, IL1B
29rhinitis10.0IL8, IL5
30arthropathy10.0TNF, IL1B
31behcet's disease10.0IL8, TNF
32periodontal disease10.0TNF, IL6
33euthyroid sick syndrome10.0IL6, IL1B
34poems syndrome10.0IL6, IL1B
35pulmonary disease, chronic obstructive10.0IL6, IL1B
36eosinophilia10.0IL8, IL5
37idiopathic pulmonary fibrosis10.0IL1B, IL8
38gastritis10.0IL8, IL1B
39eye disease10.0IL6, IL1B
40viral meningitis10.0IL8, IL6
41allergic rhinitis10.0IL8, IL5
42juvenile rheumatoid arthritis10.0IL6, TNF
43thrombocytosis10.0IL6, IL1B
44acquired immunodeficiency syndrome10.0IL1B, IL6
45allergic asthma10.0IL8, IL5
46connective tissue disease10.0TNF, IL6
47prion disease10.0IL1B, IL6
48atopic dermatitis10.0IL8, TNF, IL5
49skin disease10.0IL8, TNF, IL5
50acute pancreatitis10.0IL6, IL8

Graphical network of the top 20 diseases related to Bagassosis:



Diseases related to bagassosis

Symptoms for Bagassosis

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Drugs & Therapeutics for Bagassosis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Bagassosis

Search NIH Clinical Center for Bagassosis

Genetic Tests for Bagassosis

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Anatomical Context for Bagassosis

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33MalaCards
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MalaCards organs/tissues related to Bagassosis:

33
Lung, Skin, Liver

Animal Models for Bagassosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bagassosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.9TNF, IL5, IL6, IL1B
2MP:00053877.5IL1B, IL6, IL8, IL5, TNF
3MP:00053977.4IL1B, IL6, IL8, IL5, TNF

Publications for Bagassosis

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52PubMed
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Articles related to Bagassosis:

(show all 43)
idTitleAuthorsYear
1
Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. (15376226)
2004
2
Hypersensitivity pneumonitis: bagassosis. (7807612)
1994
3
Recent trends in bagassosis in Japan. (1637710)
1992
4
Clinical, epidemiological, and laboratory criteria for the diagnosis of bagassosis. (2305800)
1990
5
Experimental bagassosis: role of infection. (6884291)
1983
6
Pathophysiological disturbances in bagassosis and bagasse workers. (7116010)
1982
7
Elimination of bagassosis in Louisiana paper manufacturing plant workers. (627039)
1978
8
Bagassosis: a report of 8 cases. (4424270)
1974
9
Bagassosis: a histopathologic study of pulmonary biopsies from six cases. (4712724)
1973
10
Pulmonary function at rest and during exercise following bagassosis. (4995433)
1971
11
Sequential observations on pulmonary functional derangements in Bagassosis. (5111660)
1971
12
Thermoactinomyces sacchari sp. nov., a thermophilic actinomycete causing bagassosis. (4999215)
1971
13
Prevention of bagassosis by addition of propionic acid to sugar cane waste. (5201841)
1970
14
Bagassosis. (A case report). (5456139)
1970
15
Bagassosis. IV. Precipitins against extracts of thermophilic actinomycetes in patients with bagassosis. (4182997)
1969
16
Bagassosis: an epidemiological, environmental, and clinical survey. (5723350)
1968
17
Bagassosis. (4170904)
1968
18
Pulmonary function in bagassosis. (5673109)
1968
19
Immunological aspects of bagassosis. (4972748)
1968
20
Bagassosis. (5609030)
1967
21
Bagassosis II. Skin reactivity to crude bagasse extracts and atopic status of patients. (4960059)
1967
22
Bagassosis: a study of pulmonary function in 20 cases. (23841194)
1966
23
Bagassosis: I. Precipitins against extracts of crude bagasse in the serum of patients. (23841195)
1966
24
THE RESURGENCE OF BAGASSOSIS IN LOUISIANA. (14218625)
1964
25
Bagassosis. (13997509)
1963
26
Glycogen metabolism of guinea-pig in experimental bagassosis. (13913344)
1962
27
Bagassosis and silicosis in the Philippines. (14028138)
1962
28
Bagassosis: a true pnemoconiosis. (13874417)
1962
29
Metastasizing lung cancer associated with past bagassosis. (13940182)
1962
30
In vitro studies on the utilization of glucose-1-14C by guinea-pig lungs in experimental bagassosis. (13977669)
1962
31
A study of tissue respiration & respiratory enzymes of guinea-pig liver in experimental bagassosis. (14039305)
1962
32
Cellular constituents of guinea-pig lungs in experimental bagassosis. (13913343)
1962
33
Experimental bagassosis. I. Enzymes of the lung in vivo. (14447107)
1960
34
Bagassosis-a medical enigma. (13805673)
1960
35
Experimental bagassosis. II. Enzymes of lung in vitro. (14447108)
1960
36
Bagassosis; a review, with further historical data, studies of pulmonary function, and results of adrenal steroid therapy. (13559276)
1958
37
Early bagassosis. (13233534)
1955
38
Bagassosis. (13263628)
1955
39
Aerobacter cloacae endotoxin as a possible factor in the etiology of bagassosis. (18873565)
1948
40
Aerobacter cloacae as a possible factor in the etiology of bagassosis. (20987049)
1946
41
Byssinosis and Bagassosis. (20784632)
1943
42
Four Cases of Bagassosis. (20784538)
1942
43
Bagassosis: An Industrial Lung Disease. (20784500)
1942

Variations for Bagassosis

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Expression for genes affiliated with Bagassosis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bagassosis

Search GEO for disease gene expression data for Bagassosis.

Pathways for genes affiliated with Bagassosis

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 30KEGG, 54R&D Systems, 55Reactome, 60Thomson Reuters, 12EMD Millipore
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Pathways related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TNF, IL1B
29.4TNF, IL1B
3
Show member pathways
Serotonin Transporter Activity38
9.4TNF, IL1B
49.3TNF, IL8
59.1IL6, IL1B
69.0IL8, IL6
7
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.9TNF, IL8, IL5
88.8TNF, IL1B, IL8
98.7IL5, IL6, IL1B
10
Show member pathways
8.7IL1B, IL6, IL5
11
Show member pathways
8.7IL6, IL1B, IL5
128.6IL1B, IL6, TNF
138.6TNF, IL6, IL1B
148.6IL1B, IL6, TNF
158.6IL1B, IL6, TNF
16
Show member pathways
thioredoxin pathway38
8.6IL1B, IL6, TNF
17
Show member pathways
IL27-mediated signaling events38
8.6TNF, IL6, IL1B
188.6TNF, IL6, IL1B
19
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.6IL6, TNF, IL1B
20
Show member pathways
8.6IL6, TNF, IL1B
218.6IL6, IL5, IL8
22
Show member pathways
8.5IL1B, IL6, IL8
238.5IL1B, IL6, IL8
248.5IL8, IL6, TNF
258.2IL5, IL6, TNF, IL1B
268.2TNF, IL1B, IL5, IL6
27
Show member pathways
8.2IL6, TNF, IL5, IL1B
28
Show member pathways
8.2IL6, TNF, IL5, IL1B
29
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
8.2IL1B, IL6, TNF, IL5
308.1IL8, IL6, IL1B, IL5
318.0TNF, IL8, IL6, IL1B
32
Show member pathways
8.0TNF, IL8, IL6, IL1B
33
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.0IL6, TNF, IL8, IL1B
34
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.0IL1B, IL6, IL8, TNF
35
Show member pathways
8.0IL1B, IL6, IL8, TNF
368.0IL1B, IL6, IL8, TNF
378.0IL6, IL8, TNF, IL1B
388.0TNF, IL6, IL1B, IL8
398.0TNF, IL6, IL8, IL1B
40
Show member pathways
8.0IL1B, IL6, TNF, IL8
418.0IL6, IL8, TNF, IL1B
428.0IL1B, IL6, TNF, IL8
43
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.0IL1B, IL6, IL8, TNF
44
Show member pathways
Immune response MIF in innate immunity response60
8.0IL8, IL6, TNF, IL1B
45
Show member pathways
7.5IL1B, IL5, IL8, IL6, TNF
46
Show member pathways
7.5IL5, IL8, TNF, IL6, IL1B
477.5IL6, IL8, IL5, IL1B, TNF
48
Show member pathways
7.5IL5, TNF, IL1B, IL8, IL6
49
Show member pathways
7.5TNF, IL1B, IL6, IL8, IL5
50
Show member pathways
7.5IL6, IL1B, TNF, IL8, IL5

Compounds for genes affiliated with Bagassosis

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45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1rantes459.3IL5, IL1B, IL8
2toxin-1458.9TNF, IL8, IL1B
3tenidap45 299.9IL1B, TNF, IL6
4anakinra45 119.9IL6, IL1B, TNF
5gold sodium thiomalate458.9TNF, IL8, IL1B
6vesnarinone458.9TNF, IL6, IL1B
7mcp 1458.8IL5, IL8, IL6
8budesonide45 51 1110.8IL1B, TNF, IL5, IL8
9fluticasone propionate45 51 61 1111.8IL1B, IL5, TNF, IL8
10gabexate mesilate458.7IL8, IL6, TNF
11ulinastatin458.7TNF, IL6, IL8
12hbd2458.7IL1B, IL8, IL6
13ivig458.5IL6, TNF, IL5, IL1B
14imiquimod45 61 29 1111.5IL5, IL8, IL6, TNF
15thalidomide45 51 61 1111.5IL1B, TNF, IL5, IL6
16taurine chloramine458.4IL8, IL1B, IL6, TNF
17mip 1alpha458.4IL1B, TNF, IL6, IL8
18tpck458.4TNF, IL8, IL1B, IL6
19polymyxin b458.4IL8, IL6, IL1B, TNF
20groalpha458.4TNF, IL8, IL6, IL1B
21triptolide458.4IL1B, IL6, IL8, TNF
22ciglitazone45 299.4TNF, IL8, IL6, IL1B
23lipoteichoic acid458.4IL1B, IL8, TNF, IL6
24etanercept45 51 1110.4TNF, IL1B, IL6, IL8
25peptidoglycan45 299.4IL8, TNF, IL1B, IL6
26pentoxifylline45 119.4TNF, IL8, IL6, IL1B
27fmlp458.4IL1B, IL8, TNF, IL5
28ccl345 299.3IL6, IL1B, IL8, TNF
29neopterin458.3IL1B, IL6, IL8, TNF
3015-deoxy-delta-12,14-prostaglandin j2458.3IL8, IL6, IL1B, TNF
31pdtc458.3IL8, TNF, IL6, IL1B
32sp 60012545 619.3IL1B, IL6, IL8, TNF
33troglitazone45 29 61 1111.2IL6, IL1B, IL8, TNF
34endotoxin458.0IL8, TNF, IL6, IL1B
35il-12458.0TNF, IL1B, IL6, IL8, IL5
36gm-csf45 299.0IL1B, IL5, IL8, TNF, IL6
37polyinosinic-polycytidylic acid458.0IL8, IL1B, IL6, IL5, TNF
38poly(i-c)458.0TNF, IL5, IL8, IL6, IL1B
39il 10458.0TNF, IL5, IL1B, IL6, IL8
40leukotriene b445 61 2410.0IL1B, IL6, IL8, IL5, TNF
41hydrocortisone45 3 61 1111.0IL6, IL1B, IL5, TNF, IL8
42herbimycin a45 619.0TNF, IL5, IL8, IL6, IL1B
43sb 20358045 618.9IL5, IL1B, IL6, IL8, TNF
44histamine45 29 249.9IL8, IL5, IL6, IL1B, TNF
45ly294002457.9IL8, TNF, IL5, IL1B, IL6
46genistein45 29 61 3 24 1112.9IL1B, IL6, IL5, TNF, IL8
47pge2457.9TNF, IL5, IL8, IL6, IL1B
48cycloheximide457.8IL6, IL1B, IL8, IL5, TNF
49curcumin457.7IL1B, TNF, IL8, IL6
50dexamethasone45 51 29 1110.4TNF, IL5, IL8, IL6, IL1B

GO Terms for genes affiliated with Bagassosis

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16Gene Ontology
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Cellular components related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5IL5, IL8, IL6, IL1B, TNF
2extracellular spaceGO:0056157.2IL1B, IL6, IL8, IL5, TNF

Biological processes related to Bagassosis according to GeneCards/GeneDecks:

(show all 50)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of podosome assemblyGO:0718039.9TNF, IL5
2sequestering of triglycerideGO:0307309.9IL1B, TNF
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.9IL1B, TNF
4positive regulation of heterotypic cell-cell adhesionGO:0341169.9TNF, IL1B
5positive regulation of fever generationGO:0316229.9TNF, IL1B
6positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL1B
7regulation of I-kappaB kinase/NF-kappaB signalingGO:0431229.8IL1B, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:0510449.8IL1B, TNF
9negative regulation of lipid catabolic processGO:0509959.8TNF, IL1B
10positive regulation of NF-kappaB import into nucleusGO:0423469.8IL1B, TNF
11lipopolysaccharide-mediated signaling pathwayGO:0316639.8IL1B, TNF
12positive regulation of mitosisGO:0458409.8IL1B, TNF
13protein kinase B signalingGO:0434919.8IL1B, TNF
14negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.8IL1B, TNF
15cellular response to organic cyclic compoundGO:0714079.8TNF, IL1B
16positive regulation of interferon-gamma productionGO:0327299.8IL1B, TNF
17embryonic digestive tract developmentGO:0485669.7IL8, TNF
18positive regulation of JNK cascadeGO:0463309.7IL1B, TNF
19neutrophil chemotaxisGO:0305939.6IL8, IL1B
20calcium-mediated signalingGO:0197229.6IL8, TNF
21MAPK cascadeGO:0001659.6IL1B, TNF
22positive regulation of immunoglobulin secretionGO:0510249.6IL5, IL6
23positive regulation of JAK-STAT cascadeGO:0464279.6IL5, IL6
24epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.6TNF, IL6
25negative regulation of lipid storageGO:0108889.5TNF, IL6
26positive regulation of chemokine productionGO:0327229.5IL6, TNF
27regulation of insulin secretionGO:0507969.5IL1B, TNF
28defense response to Gram-positive bacteriumGO:0508309.5TNF, IL6
29negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
30positive regulation of protein phosphorylationGO:0019349.4IL1B, TNF
31positive regulation of smooth muscle cell proliferationGO:0486619.4IL6, TNF
32positive regulation of T cell proliferationGO:0421029.4IL6, IL1B
33positive regulation of peptidyl-serine phosphorylationGO:0331389.4IL6, TNF
34response to mechanical stimulusGO:0096129.4IL6, TNF
35positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4IL6, IL5
36humoral immune responseGO:0069599.4TNF, IL6
37activation of MAPK activityGO:0001879.3IL1B, TNF
38positive regulation of protein kinase B signalingGO:0518979.3TNF, IL6
39response to glucocorticoidGO:0513849.2IL6, TNF
40immune responseGO:0069559.2IL5, IL8, IL1B
41cytokine-mediated signaling pathwayGO:0192219.1IL5, IL6, IL1B
42positive regulation of nitric oxide biosynthetic processGO:0454299.1IL1B, IL6, TNF
43positive regulation of interleukin-6 productionGO:0327559.1TNF, IL6, IL1B
44positive regulation of NF-kappaB transcription factor activityGO:0510929.0IL1B, IL6, TNF
45positive regulation of ERK1 and ERK2 cascadeGO:0703748.8IL6, TNF
46positive regulation of transcription from RNA polymerase II promoterGO:0459448.6TNF, IL6, IL1B
47positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.6TNF, IL5, IL6, IL1B
48positive regulation of transcription, DNA-templatedGO:0458938.6TNF, IL5, IL6, IL1B
49negative regulation of cell proliferationGO:0082858.4TNF, IL8, IL6, IL1B
50inflammatory responseGO:0069548.0IL1B, IL6, IL8, IL5, TNF

Molecular functions related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.2IL1B, IL6, IL5, TNF

Products for genes affiliated with Bagassosis

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  • Antibodies
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Sources for Bagassosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet