MCID: BGS001
MIFTS: 45

Bagassosis malady

Respiratory diseases category

Summaries for Bagassosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

MalaCards: Bagassosis, also known as sugar cane worker pneumonitis, is related to silicosis and byssinosis. An important gene associated with Bagassosis is IL5 (interleukin 5 (colony-stimulating factor, eosinophil)), and among its related pathways are Rho Family GTPases and TGF-Beta Pathway. The compounds hydrocortisone and gm-csf have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and skin, and related mouse phenotype tumorigenesis.

Wikipedia:63 Bagassosis, an interstitial lung disease, is a type of hypersensitivity pneumonitis attributed to... more...

Aliases & Classifications for Bagassosis

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

bagassosis 8 60
sugar cane worker pneumonitis 8


External Ids:

Disease Ontology8 DOID:12522
NCIt39 C34409
ICD9CM27 495.1
SNOMED-CT56 67242002
MeSH34 D011009
ICD1025 J67.1

Related Diseases for Bagassosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Bagassosis:



Diseases related to bagassosis

Clinical Features for Bagassosis

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Drugs & Therapeutics for Bagassosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Bagassosis

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Anatomical Context for Bagassosis

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32MalaCards
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MalaCards organs/tissues related to Bagassosis:

32
Lung, Liver, Skin

Animal Models for Bagassosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bagassosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5IL6, IL1B, IL5, TNF

Publications for Bagassosis

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50PubMed
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Articles related to Bagassosis:

(show all 44)
idTitleAuthorsYear
1
Differences in cellular and inflammatory cytokine profiles in the bronchoalveolar lavage fluid in bagassosis and silicosis. (15376226)
2004
2
Hypersensitivity pneumonitis: bagassosis. (7807612)
1994
3
Recent trends in bagassosis in Japan. (1637710)
1992
4
Clinical, epidemiological, and laboratory criteria for the diagnosis of bagassosis. (2305800)
1990
5
Experimental bagassosis: role of infection. (6884291)
1983
6
Pathophysiological disturbances in bagassosis and bagasse workers. (7116010)
1982
7
Elimination of bagassosis in Louisiana paper manufacturing plant workers. (627039)
1978
8
Bagassosis: a report of 8 cases. (4424270)
1974
9
Bagassosis: a histopathologic study of pulmonary biopsies from six cases. (4712724)
1973
10
Pulmonary function at rest and during exercise following bagassosis. (4995433)
1971
11
Sequential observations on pulmonary functional derangements in Bagassosis. (5111660)
1971
12
Thermoactinomyces sacchari sp. nov., a thermophilic actinomycete causing bagassosis. (4999215)
1971
13
Prevention of bagassosis by addition of propionic acid to sugar cane waste. (5201841)
1970
14
Bagassosis. (A case report). (5456139)
1970
15
Bagassosis. IV. Precipitins against extracts of thermophilic actinomycetes in patients with bagassosis. (4182997)
1969
16
Bagassosis: an epidemiological, environmental, and clinical survey. (5723350)
1968
17
Bagassosis. (4170904)
1968
18
Pulmonary function in bagassosis. (5673109)
1968
19
Immunological aspects of bagassosis. (4972748)
1968
20
Bagassosis. (5609030)
1967
21
Bagassosis II. Skin reactivity to crude bagasse extracts and atopic status of patients. (4960059)
1967
22
Bagassosis: a study of pulmonary function in 20 cases. (23841194)
1966
23
Bagassosis: I. Precipitins against extracts of crude bagasse in the serum of patients. (23841195)
1966
24
THE RESURGENCE OF BAGASSOSIS IN LOUISIANA. (14218625)
1964
25
Bagassosis. (13997509)
1963
26
Glycogen metabolism of guinea-pig in experimental bagassosis. (13913344)
1962
27
Bagassosis and silicosis in the Philippines. (14028138)
1962
28
Bagassosis: a true pnemoconiosis. (13874417)
1962
29
Metastasizing lung cancer associated with past bagassosis. (13940182)
1962
30
In vitro studies on the utilization of glucose-1-14C by guinea-pig lungs in experimental bagassosis. (13977669)
1962
31
A study of tissue respiration & respiratory enzymes of guinea-pig liver in experimental bagassosis. (14039305)
1962
32
Cellular constituents of guinea-pig lungs in experimental bagassosis. (13913343)
1962
33
The glycolytic enzymes of guinea-pig lung in experimental bagassosis. (16748890)
1961
34
Experimental bagassosis. I. Enzymes of the lung in vivo. (14447107)
1960
35
Bagassosis-a medical enigma. (13805673)
1960
36
Experimental bagassosis. II. Enzymes of lung in vitro. (14447108)
1960
37
Bagassosis; a review, with further historical data, studies of pulmonary function, and results of adrenal steroid therapy. (13559276)
1958
38
Early bagassosis. (13233534)
1955
39
Bagassosis. (13263628)
1955
40
Aerobacter cloacae endotoxin as a possible factor in the etiology of bagassosis. (18873565)
1948
41
Aerobacter cloacae as a possible factor in the etiology of bagassosis. (20987049)
1946
42
Byssinosis and Bagassosis. (20784632)
1943
43
Four Cases of Bagassosis. (20784538)
1942
44
Bagassosis: An Industrial Lung Disease. (20784500)
1942

Genetic Variations for Bagassosis

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Expression for genes affiliated with Bagassosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bagassosis

Search GEO for disease gene expression data for Bagassosis.

Pathways for genes affiliated with Bagassosis

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 12EMD Millipore
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Pathways related to Bagassosis according to GeneCards/GeneDecks:

(show all 47)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.1IL5
2
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10.1IL5
3
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10.1IL5
4
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10.1IL5
5
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10.1IL5
6
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10.1IL5
710.1IL8
8
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10.1IL8
99.6IL1B, IL8
109.5IL6, IL8
119.5IL6, IL8
129.4TNF, IL8
139.4IL1B, TNF
149.4IL1B, TNF
159.4IL1B, TNF
169.4TNF, IL1B
179.2IL6, IL8, IL5
18
Hide members
9.1IL6, IL1B, IL5
199.1IL6, IL1B, IL5
20
Hide members
9.1IL5, IL1B, IL6
219.1IL6, IL1B, IL8
22
Hide members
9.1TNF, IL5, IL8
239.0IL1B, IL8, TNF
248.9IL6, IL8, TNF
25
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8.9IL6, IL1B, TNF
268.9IL6, IL1B, TNF
278.9IL6, IL1B, TNF
28
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8.9IL6, IL1B, TNF
298.9IL6, IL1B, TNF
308.9TNF, IL1B, IL6
318.9TNF, IL1B, IL6
32
Development PDGF signaling via STATs and NF-kB
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8.9TNF, IL1B, IL6
338.9TNF, IL1B, IL6
348.7IL6, IL1B, IL8, IL5
35
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8.5IL6, IL1B, IL5, TNF
368.5TNF, IL5, IL1B, IL6
37
Hide members
8.5IL6, IL1B, IL8, TNF
388.5IL6, IL1B, IL8, TNF
39
Hide members
8.5IL6, IL1B, IL8, TNF
40
Hide members
8.5TNF, IL8, IL1B, IL6
418.5TNF, IL8, IL1B, IL6
42
Immune response Bacterial infections in normal airways
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8.5TNF, IL8, IL1B, IL6
43
Hide members
8.5TNF, IL8, IL1B, IL6
448.5TNF, IL8, IL1B, IL6
45
Hide members
8.5TNF, IL8, IL1B, IL6
468.1IL6, IL1B, IL8, IL5, TNF
47
Hide members
8.1TNF, IL5, IL8, IL1B, IL6

Compounds for genes affiliated with Bagassosis

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Sources:
44Novoseek, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Bagassosis according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1hydrocortisone44 2 59 1113.5IL8
2gm-csf44 2811.3TNF
3fmlp4410.3IL5
4anaphylatoxin449.7IL1B, IL8
5mcp 1449.5IL5, IL8, IL6
6hbd2449.4IL8, IL1B, IL6
7toxin-1449.3TNF, IL8, IL1B
8gold sodium thiomalate449.3IL1B, IL8, TNF
9anakinra44 1110.2IL6, IL1B, TNF
10vesnarinone449.2IL6, IL1B, TNF
115 aminosalicylic acid449.2IL1B, IL8, TNF
12staurosporin449.2TNF, IL8, IL1B
13budesonide44 49 1111.0TNF, IL5, IL8, IL1B
14fluticasone propionate44 49 59 1112.0TNF, IL5, IL8, IL1B
15leflunomide49 44 1111.0TNF, IL1B, IL6
16imiquimod44 28 59 1112.0TNF, IL5, IL8, IL6
17parthenolide44 29.9TNF, IL8, IL6
188-isoprostane448.9IL6, IL8, TNF
19taurine chloramine448.9TNF, IL8, IL1B, IL6
20mip 1alpha448.9IL6, IL1B, IL8, TNF
21tpck448.9TNF, IL8, IL1B, IL6
22polymyxin b448.9TNF, IL8, IL1B, IL6
23sulfasalazine44 28 49 1111.9IL1B, IL8, TNF
24groalpha448.9IL6, IL1B, IL8, TNF
25triptolide448.9TNF, IL8, IL1B, IL6
26ciglitazone44 289.9TNF, IL8, IL1B, IL6
27lipoteichoic acid448.9TNF, IL8, IL1B, IL6
28etanercept44 49 1110.9IL6, IL1B, IL8, TNF
29peptidoglycan44 289.9TNF, IL8, IL1B, IL6
30ccl344 289.8IL6, IL1B, IL8, TNF
31thalidomide44 49 59 1111.8TNF, IL5, IL1B, IL6
32neopterin448.8TNF, IL8, IL1B, IL6
3315-deoxy-delta-12,14-prostaglandin j2448.8IL6, IL1B, IL8, TNF
34pdtc448.8TNF, IL8, IL1B, IL6
35sp 60012544 599.8TNF, IL8, IL1B, IL6
36troglitazone44 28 59 1111.7TNF, IL8, IL1B, IL6
37curcumin448.6IL6, IL1B, IL8, TNF
38il-12448.5IL6, IL1B, IL8, IL5, TNF
39polyinosinic-polycytidylic acid448.5TNF, IL5, IL8, IL1B, IL6
40poly(i-c)448.5TNF, IL5, IL8, IL1B, IL6
41il 10448.5IL6, IL1B, IL8, IL5, TNF
42leukotriene b444 59 2410.5TNF, IL5, IL8, IL1B, IL6
43herbimycin a44 599.5TNF, IL5, IL8, IL1B, IL6
44rantes448.5TNF, IL5, IL8, IL1B, IL6
45sb 20358044 599.5TNF, IL5, IL8, IL1B, IL6
46histamine44 28 2410.4TNF, IL5, IL8, IL1B, IL6
47ly294002448.4TNF, IL5, IL8, IL1B, IL6
48genistein44 28 59 2 11 2413.4TNF, IL5, IL8, IL1B, IL6
49pge2448.3TNF, IL5, IL8, IL1B, IL6
50methotrexate44 49 1110.2TNF, IL5, IL1B, IL6

GO Terms for genes affiliated with Bagassosis

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16Gene Ontology
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Cellular components related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.1IL5, IL8, IL1B, IL6, TNF
2extracellular spaceGO:0056157.8IL6, IL1B, IL8, IL5, TNF

Biological processes related to Bagassosis according to GeneCards/GeneDecks:

(show all 39)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL5, IL6
2positive regulation of JAK-STAT cascadeGO:0464279.9IL5, IL6
3positive regulation of podosome assemblyGO:0718039.9IL5, TNF
4sequestering of triglycerideGO:0307309.8IL1B, TNF
5positive regulation of calcidiol 1-monooxygenase activityGO:0605599.8IL1B, TNF
6positive regulation of heterotypic cell-cell adhesionGO:0341169.8TNF, IL1B
7positive regulation of fever generationGO:0316229.8IL1B, TNF
8embryonic digestive tract developmentGO:0485669.8TNF, IL8
9positive regulation of chemokine biosynthetic processGO:0450809.8TNF, IL1B
10neutrophil chemotaxisGO:0305939.8IL1B, IL8
11regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431229.8IL1B, TNF
12positive regulation of membrane protein ectodomain proteolysisGO:0510449.7TNF, IL1B
13negative regulation of lipid catabolic processGO:0509959.7IL1B, TNF
14epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.7TNF, IL6
15negative regulation of lipid storageGO:0108889.7TNF, IL6
16positive regulation of NF-kappaB import into nucleusGO:0423469.7IL1B, TNF
17negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.7TNF, IL1B
18positive regulation of mitosisGO:0458409.7TNF, IL1B
19lipopolysaccharide-mediated signaling pathwayGO:0316639.7TNF, IL1B
20positive regulation of chemokine productionGO:0327229.7TNF, IL6
21cellular response to organic cyclic compoundGO:0714079.7IL1B, TNF
22protein kinase B signaling cascadeGO:0434919.6TNF, IL1B
23positive regulation of interferon-gamma productionGO:0327299.6IL1B, TNF
24negative regulation of fat cell differentiationGO:0455999.6IL6, TNF
25defense response to Gram-positive bacteriumGO:0508309.5TNF, IL6
26calcium-mediated signalingGO:0197229.4IL8, TNF
27positive regulation of smooth muscle cell proliferationGO:0486619.4IL6, TNF
28cytokine-mediated signaling pathwayGO:0192219.4IL6, IL1B, IL5
29positive regulation of T cell proliferationGO:0421029.4IL1B, IL6
30humoral immune responseGO:0069599.4TNF, IL6
31positive regulation of nitric oxide biosynthetic processGO:0454299.3IL6, IL1B, TNF
32positive regulation of interleukin-6 productionGO:0327559.3TNF, IL1B, IL6
33positive regulation of NF-kappaB transcription factor activityGO:0510929.2IL6, IL1B, TNF
34immune responseGO:0069559.2IL1B, IL8, IL5
35response to mechanical stimulusGO:0096129.0TNF, IL6
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL6, IL1B, IL5, TNF
37positive regulation of transcription, DNA-dependentGO:0458938.9TNF, IL5, IL1B, IL6
38negative regulation of cell proliferationGO:0082858.9TNF, IL8, IL1B, IL6
39inflammatory responseGO:0069548.5TNF, IL5, IL8, IL1B, IL6

Molecular functions related to Bagassosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051258.5IL6, IL1B, IL5, TNF

Products for genes affiliated with Bagassosis

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Sources for Bagassosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet