MCID: BLN010
MIFTS: 36

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and urethritis. An important gene associated with Balanitis is TGM2 (Transglutaminase 2). The drugs Acetaminophen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related phenotype is behavior/neurological.

Wikipedia : 72 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 32.9 TGM1 TGM2 TGM3
2 urethritis 30.1 MRAP PHB2
3 leukoplakia of penis 11.5
4 lichen sclerosus 11.3
5 balanoposthitis 11.3
6 phimosis 11.3
7 lichen sclerosus et atrophicus 11.2
8 peyronie's disease 10.9
9 hypospadias 10.6
10 urethral stricture 10.1
11 squamous cell carcinoma 10.0
12 penile cancer, adult 10.0
13 vulvitis 10.0
14 iritis 9.9 MRAP PHB2
15 mucositis 9.9
16 penis carcinoma in situ 9.9
17 enthesopathy 9.9 MRAP PHB2
18 bursitis 9.9 MRAP PHB2
19 dermatitis herpetiformis 9.9 TGM2 TGM3
20 tendinitis 9.9 MRAP PHB2
21 transient arthritis 9.8 MRAP PHB2
22 arthritis 9.8
23 vulvovaginitis 9.8
24 necrobiosis lipoidica 9.8
25 syphilis 9.8
26 reactive arthritis 9.8
27 herpes simplex 9.8
28 urethral syndrome 9.8 MRAP PHB2
29 netherton syndrome 9.8 TGM1 TGM3
30 conjunctival disease 9.8 MRAP PHB2
31 ige responsiveness, atopic 9.7
32 leprosy 3 9.7
33 aging 9.7
34 cicatricial pemphigoid 9.7
35 telangiectasis 9.7
36 paronychia 9.7
37 uveitis 9.7
38 cystitis 9.7
39 vaginitis 9.7
40 gingivitis 9.7
41 proctitis 9.7
42 fibrosarcoma 9.7
43 primary syphilis 9.7
44 hyperglycemia 9.7
45 pustulosis of palm and sole 9.7
46 adenosquamous carcinoma 9.7
47 conjunctivitis 9.7
48 herpes zoster 9.7
49 psoriasis 9.7
50 pemphigus 9.7

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

MGI Mouse Phenotypes related to Balanitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 PHB2 SLC5A2 TGM1 TGM2 TGM3

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 1 103-90-2 1983
2
Bupivacaine Approved, Investigational Phase 1 38396-39-3, 2180-92-9 2474
3
Ibuprofen Approved Phase 1 15687-27-1 3672
4
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
5
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
6 Anti-Infective Agents Phase 1
7 Analgesics Phase 1
8 Analgesics, Non-Narcotic Phase 1
9 Anesthetics Phase 1
10 Anesthetics, General Phase 1
11 Anesthetics, Inhalation Phase 1
12 Anesthetics, Local Phase 1
13 Anti-Inflammatory Agents Phase 1
14 Anti-Inflammatory Agents, Non-Steroidal Phase 1
15 Antipyretics Phase 1
16 Antirheumatic Agents Phase 1
17 Central Nervous System Depressants Phase 1
18 Cyclooxygenase Inhibitors Phase 1
19 Ketorolac Tromethamine Phase 1
20 Peripheral Nervous System Agents Phase 1
21 Platelet Aggregation Inhibitors Phase 1
22
Menthol Approved 2216-51-5 16666
23
Triamcinolone Approved, Vet_approved 124-94-7 31307
24
Adenosine Approved, Investigational 58-61-7 60961
25
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
26 glucocorticoids
27 Hormone Antagonists
28 Hormones
29 Hormones, Hormone Substitutes, and Hormone Antagonists
30 Immunosuppressive Agents
31 Retinol palmitate
32 triamcinolone acetonide
33 Triamcinolone diacetate
34 Triamcinolone hexacetonide
35 retinol Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
2 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Recruiting NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
3 Circumcision Versus Preputioplasty for BXO in Children Recruiting NCT02854995
4 Susceptibility Genes in Autism Spectrum Disorders Recruiting NCT02628808

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

38
Skin, T Cells, Bone, Bone Marrow

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 298)
# Title Authors Year
1
Balanitis associated with FOLFIRI chemotherapy. ( 29387750 )
2018
2
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
3
Circinate Balanitis. ( 28076706 )
2017
4
Successful Management of Zoon's Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris. ( 28382428 )
2017
5
Image Gallery: Generalized circinate cutaneous lesions simulating circinate balanitis. ( 29192976 )
2017
6
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
7
A case of Zoon Balanitis in an immune-competent teenager. ( 28895662 )
2017
8
Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen. ( 28406530 )
2017
9
Zoon's balanitis treated with topical tacrolimus. ( 28479782 )
2017
10
Zoon Balanitis Revisited: Report of Balanitis Circumscripta Plasmacellularis Resolving With Topical Mupirocin Ointment Monotherapy. ( 28301626 )
2017
11
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2017
12
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
13
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
14
Reflectance confocal microscopy as a non-invasive complementary tool in the diagnosis of psoriatic balanitis. ( 27514619 )
2016
15
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2016
16
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2016
17
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2016
18
The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature. ( 27421838 )
2016
19
Streptococcus pyogenes as the cause of vulvovaginitis and balanitis in children from Nis, Serbia. ( 27638252 )
2016
20
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
21
Contact balanitis to tromantadine. ( 27757977 )
2016
22
Zoon balanitis: A comprehensive review. ( 27890945 )
2016
23
Pseudoepitheliomatous, Keratotic and Micaceous Balanitis: A Case Report. ( 26557598 )
2015
24
ZOON's BALANITIS SUCCESSFULLY TREATED WITH PHOTODYNAMIC THERAPY: CASE REPORT AND LITERATURE REVIEW. ( 26321748 )
2015
25
Circinate balanitis as the presenting symptom of sexually-acquired reactive arthritis: a case report. ( 25918330 )
2015
26
Reiter's disease: Circinate balanitis as alone preceding presentation - Successfully treated with pimecrolimus 1% cream. ( 26392659 )
2015
27
Balanitis is a risk factor for herpes zoster. ( 25596845 )
2015
28
Dermoscopy of Zoon's plasma cell balanitis. ( 26670716 )
2015
29
Candida albicans and Streptococcus pyogenes balanitis: diabetes or STI? ( 26232734 )
2015
30
Zoon's balanitis. ( 25763417 )
2014
31
Meatal Stenosis in Boys following Circumcision for Lichen Sclerosus (Balanitis Xerotica Obliterans). ( 24992332 )
2014
32
Successful use of dapsone for the management of circinate balanitis. ( 24635073 )
2014
33
Therapeutic Efficacy of Topical Calcineurin Inhibitors in Plasma Cell Balanitis: Case Series and Review of the Literature. ( 24434685 )
2014
34
Approach to balanitis/balanoposthitis: Current guidelines. ( 26396455 )
2014
35
Treatment of pseudoepitheliomatous, keratotic, and micaceous balanitis with topical photodynamic therapy. ( 25266766 )
2014
36
Dermoscopy in plasma cell balanitis: its usefulness in diagnosis and follow-up. ( 25176141 )
2014
37
Pseudoepitheliomatous keratotic and micaceous balanitis of Civatte. ( 24860747 )
2014
38
Plasma cell (Zoon) balanitis: another inflammatory disorder that can be rich in IgG4+ plasma cells. ( 25216321 )
2014
39
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. ( 24704927 )
2014
40
Clinical study of the effectiveness of the A<water of the 3 sulfatesA> on balanitis and balanoposthitis. ( 25262388 )
2014
41
Photodynamic therapy for Zoon balanitis. ( 25333228 )
2014
42
Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin. ( 23806570 )
2013
43
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
44
Pseudoepitheliomatous keratotic and micaceous balanitis. ( 24339464 )
2013
45
Pseudoepitheliomatous, keratotic, micaceous balanitis and lichen sclerosus: two sides of the same coin. ( 24005152 )
2013
46
Granulomatous balanitis after intravesical Bacille Calmette-GuAcrin instillation. ( 23177394 )
2013
47
Balanitis xerotica obliterans in children and adolescents: A literature review and clinical series. ( 24295833 )
2013
48
Pseudoepitheliomatous keratotic and micaceous balanitis with malignant transformation. ( 23919054 )
2013
49
Circumcision as treatment for Zoon's balanitis in an HIV-positive teenage patient. ( 23970603 )
2013
50
Syphilitic balanitis of Follmann. ( 24134463 )
2013

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.02 PHB2 SLC5A2 TGM1 TGM2 TGM3

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.32 TGM1 TGM3
2 cellular protein modification process GO:0006464 9.26 TGM1 TGM3
3 keratinocyte differentiation GO:0030216 9.16 TGM1 TGM3
4 cell envelope organization GO:0043163 8.96 TGM1 TGM3
5 peptide cross-linking GO:0018149 8.8 TGM1 TGM2 TGM3

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
2 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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