Barrett Esophagus/esophageal Adenocarcinoma malady
Categories: Genetic diseases, Cancer diseases, Gastrointestinal diseases, Rare diseases
Aliases & Descriptions for Barrett Esophagus/esophageal Adenocarcinoma:
Orphanet epidemiological data:52
adenocarcinoma of esophagus:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult
barrett esophagus/esophageal adenocarcinoma:
Inheritance: somatic mutation
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Gastrointestinal diseases
ICD10: 29 28
Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
Rare gastroenterological diseases
NIH Rare Diseases:46 Barrett esophagus is a condition in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestines. although this change does not cause any specific signs or symptoms, it is typically diagnosed in people who have long-term gastroesophageal reflux disease (gerd). the exact underlying cause of barrett esophagus is not known; however, it generally occurs sporadically in people with no family history of the condition. treatment varies by the severity of the condition and generally includes medications and life style modifications to ease the symptoms of gerd. endoscopic or surgical treatments may be recommended in people with severe cases. last updated: 7/13/2015
MalaCards based summary: Barrett Esophagus/esophageal Adenocarcinoma, also known as barrett esophagus, is related to esophageal cancer and gastric cancer, and has symptoms including obesity, weight loss and feeding difficulties in infancy. An important gene associated with Barrett Esophagus/esophageal Adenocarcinoma is ASCC1 (Activating Signal Cointegrator 1 Complex Subunit 1), and among its related pathways are DNA damage_ATM/ATR regulation of G1/S checkpoint and Bladder cancer. The drugs cisplatin and methotrexate have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and endothelial, and related mouse phenotypes are neoplasm and immune system.
UniProtKB/Swiss-Prot:68 Barrett esophagus: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.
OMIM:50 Barrett esophagus, or Barrett metaplasia, describes the phenotypic change of normal esophageal squamous epithelium to a... (614266) more...
Clinical features from OMIM:614266
Symptoms:52 (show all 10)
HPO human phenotypes related to Barrett Esophagus/esophageal Adenocarcinoma:(show all 11)
UMLS symptoms related to Barrett Esophagus/esophageal Adenocarcinoma:abdominal pain, constipation, diarrhea, dyspepsia, heartburn, nausea and vomiting, swallowing problem, gastrointestinal gas, coughing, snoring, sore throat, vertigo/dizziness, equilibration disorder
FDA approved drugs:(show all 199)