MCID: BRR013
MIFTS: 46

Barrett Esophagus/esophageal Adenocarcinoma malady

Gastrointestinal, Cancer categories

Summaries for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

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Wikipedia:64 Esophageal cancer (or oesophageal cancer) is malignancy of the esophagus. There are various subtypes,... more...

MalaCards: Barrett Esophagus/esophageal Adenocarcinoma, also known as adenocarcinoma of esophagus, is related to barrett's esophagus and adenocarcinoma, and has symptoms including endobrachyesophagus/barrett esophagus, feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia and gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia. An important gene associated with Barrett Esophagus/esophageal Adenocarcinoma is CTHRC1 (collagen triple helix repeat containing 1), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Synthesis of bile acids and bile salts. The compounds 1,3,7,12-Tetrahydroxycholan-24-oic acid and 1,3,12-Trihydroxycholan-24-oic acid have been mentioned in the context of this disorder. Affiliated tissues include b cells and endothelial, and related mouse phenotypes are integument and liver/biliary system.

Description from OMIM:47 614266

Aliases & Classifications for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
61UMLS, 47OMIM, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Characteristics (Orphanet epidemiological data):

49
esophageal adenocarcinoma:
Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

barrett esophagus/esophageal adenocarcinoma 47
adenocarcinoma of esophagus 61
esophageal adenocarcinoma 49


External Ids:

OMIM47 614266
ICD10 via Orphanet26 C15

Related Diseases for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Barrett Esophagus/esophageal Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1barrett's esophagus31.2SOD2, GPX2, TERC, GSTP1
2adenocarcinoma30.3GSTP1, TIMP3, SOD2, MYB, GPX2, ABCC3
3squamous cell carcinoma30.1TIMP3, SOD2, PKP1, MYB, TERC, ERCC2
4barrett's adenocarcinoma10.9
5gastroesophageal reflux disease10.4
6achalasia10.2
7anal squamous cell carcinoma10.2
8bile reflux10.1
9h. pylori infection10.1
10esophageal squamous cell carcinoma10.1
11ureteral obstruction10.0
12cystic fibrosis10.0
13tuberous sclerosis10.0
14signet ring cell adenocarcinoma10.0
15intussusception10.0
16myositis ossificans10.0
17ureter adenocarcinoma10.0
18congenital diaphragmatic hernia10.0
19n syndrome10.0
20juvenile polyposis syndrome10.0
21vitiligo10.0
22bladder adenocarcinoma10.0
23breast adenocarcinoma10.0
24tuberous sclerosis complex10.0
25cerebellar degeneration10.0
26tracheoesophageal fistula10.0
27paraneoplastic cerebellar degeneration10.0
28radiation induced cancer10.0
29esophagitis10.0SOD2
30hepatitis10.0SOD2
31myeloid leukemia10.0MYB
32esophageal cancer10.0GSTP1
33thyroid cancer10.0TIMP3
34galactosemia10.0SOD2
35leukoplakia10.0TERC
36age related macular degeneration10.0TIMP3
37obesity10.0AKR1C2, SOD2
38medulloblastoma10.0DKK1, TIMP3
39testicular cancer10.0ERCC2, MYB
40infertility10.0TERC
41malignant glioma10.0GSTP1, TERC, ABCC3
42skin cancer10.0ERCC2, TERC
43cervical cancer10.0TIMP3, TERC, GSTP1
44hepatitis c10.0MYB, SOD2, TIMP3
45oral cancer10.0SOD2, TERC, GSTP1
46endometrial carcinoma10.0GSTP1, TERC, TIMP3
47pulmonary fibrosis10.0TERC
48acute leukemia10.0GSTP1, TERC, ABCC3, MYB
49myeloma10.0DKK1, TIMP3
50atherosclerosis10.0MSR1, SLC10A2, SOD2, TIMP3

Graphical network of the top 20 diseases related to Barrett Esophagus/esophageal Adenocarcinoma:



Diseases related to barrett esophagus/esophageal adenocarcinoma

Clinical Features for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

614266

Symptoms:

49 (show all 10)
  • endobrachyesophagus/barrett esophagus
  • feeding disorder/dysphagia/swallowing/sucking disorder/esophageal dyskinesia
  • gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
  • esophageal neoplasm/tumor/carcinoma/cancer
  • generalized obesity
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • thoracic/chest pain
  • cough
  • lymphadenopathy/polyadenopathies

Drugs & Therapeutics for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Barrett Esophagus/esophageal Adenocarcinoma

Drug clinical trials:

Search ClinicalTrials for Barrett Esophagus/esophageal Adenocarcinoma

Search NIH Clinical Center for Barrett Esophagus/esophageal Adenocarcinoma

Search CenterWatch for Barrett Esophagus/esophageal Adenocarcinoma

Genetic Tests for Barrett Esophagus/esophageal Adenocarcinoma

Anatomical Context for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Barrett Esophagus/esophageal Adenocarcinoma:

33
B cells, Endothelial

Animal Models for Barrett Esophagus/esophageal Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Barrett Esophagus/esophageal Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0SOD2, MYB, ABCC3, TERC, GSTP1, TIMP3
2MP:00053709.8TIMP3, SOD2, FABP6, CTHRC1, MYB, ABCC3
3MP:00053769.4ERCC2, TIMP3, SOD2, FABP6, CTHRC1, DKK1
4MP:00053879.4C1QA, TIMP3, SOD2, MYB, GPX2, TERC

Publications for Barrett Esophagus/esophageal Adenocarcinoma

Sources:
51PubMed
See all sources

Articles related to Barrett Esophagus/esophageal Adenocarcinoma:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Radiofrequency ablation and endoscopic mucosal resection for dysplastic barrett's esophagus and early esophageal adenocarcinoma: outcomes of the UK National Halo RFA Registry. (23542069)
2013
2
Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma. (23466711)
2013
3
Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. (24132576)
2013
4
Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma. (24117642)
2013
5
Impact of endoscopic surveillance on mortality from Barrett's esophagus-associated esophageal adenocarcinomas. (23673354)
2013
6
Development of esophageal adenocarcinoma on buried glands following radiofrequency ablation for Barrett's esophagus. (23139037)
2012
7
Patients with partial gastrectomy and Barrett esophagus are in higher risk to develop esophageal adenocarcinoma than those with Barretts without gastrectomy. (22580662)
2012
8
Longer inspection time is associated with increased detection of high-grade dysplasia and esophageal adenocarcinoma in Barrett's esophagus. (22732877)
2012
9
Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. (22664470)
2012
10
Ki-67 and Bax expression in esophageal mucosa might have implications in ablative therapies for Barrett's esophagus, dysplasia, and adenocarcinoma. (21858571)
2012
11
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. (21951971)
2012
12
Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus. (22355271)
2012
13
Prevalence of extra-esophageal cancers in patients with Barrett's esophagus and esophageal adenocarcinoma. (23600048)
2012
14
The impact of endoscopic ultrasound findings on clinical decision making in Barrett's esophagus with high-grade dysplasia or early esophageal adenocarcinoma. (23016606)
2012
15
Epithelial mesenchymal transition and cancer stem cells in esophageal adenocarcinoma originating from Barrett's esophagus. (22783391)
2012
16
Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (21791690)
2011
17
Does impaired gallbladder function contribute to the development of Barrett's esophagus and esophageal adenocarcinoma? (21484485)
2011
18
Patients with nondysplastic Barrett's esophagus have low risks for developing dysplasia or esophageal adenocarcinoma. (21115133)
2011
19
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma. (21977915)
2011
20
DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. (22139570)
2011
21
Effect of Helicobacter pylori infection on Barrett's esophagus and esophageal adenocarcinoma formation in a rat model of chronic gastroesophageal reflux. (21241415)
2011
22
Familial Barrett's esophagus: clues to genetic risks for esophageal adenocarcinoma. (21461914)
2011
23
Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues. (20543560)
2010
24
Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. (19549212)
2010
25
Esophageal adenocarcinoma after Nissen's fundoplication for Barrett's esophagus: report of a case. (21110164)
2010
26
Expression of C1q complement component in Barrett's esophagus and esophageal adenocarcinoma. (20496011)
2010
27
Endoscopic therapy of Barrett's esophagus and esophageal adenocarcinoma. (20593060)
2010
28
MicroRNA expression signatures in Barrett's esophagus and esophageal adenocarcinoma. (19737949)
2009
29
Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma. (19417022)
2009
30
Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis. (19222528)
2009
31
Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett's esophagus. (19524578)
2009
32
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma. (19773200)
2009
33
Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. (19396460)
2009
34
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. (17849424)
2008
35
No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. (18349297)
2008
36
Incidence of esophageal adenocarcinoma in patients with Barrett's esophagus and high-grade dysplasia: a meta-analysis. (18045592)
2008
37
Endoscopic resection for Barrett's esophagus with high-grade dysplasia or early esophageal adenocarcinoma. (19251170)
2008
38
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma. (18396902)
2008
39
Patient preferences for the chemoprevention of esophageal adenocarcinoma in Barrett's esophagus. (18775019)
2008
40
Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma. (17585859)
2007
41
Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. (17338734)
2007
42
A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma. (17277236)
2007
43
Familial trends of inheritance in gastro esophageal reflux disease, Barrett's esophagus and Barrett's adenocarcinoma: 20 families. (17227311)
2007
44
Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus. (17085323)
2006
45
Advances in Barrett's esophagus and esophageal adenocarcinoma. (15887151)
2005
46
Cyclooxygenase-2 inhibitor therapy for the prevention of esophageal adenocarcinoma in Barrett's esophagus. (11904306)
2002
47
Expression of acidic fibroblast growth factor in Barrett's esophagus and associated esophageal adenocarcinoma. (9375615)
1997
48
E-cadherin expression in gastroesophageal reflux disease, Barrett's esophagus, and esophageal adenocarcinoma: an immunohistochemical and immunoblot study. (7572899)
1995
49
Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma. (7906678)
1994
50
Chemopreventive studies in Barrett's esophagus: a model premalignant lesion for esophageal adenocarcinoma. (1389696)
1992

Genetic Variations for Barrett Esophagus/esophageal Adenocarcinoma

Expression for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

Search GEO for disease gene expression data for Barrett Esophagus/esophageal Adenocarcinoma.

Pathways for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

Sources:
24HMDB, 45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Barrett Esophagus/esophageal Adenocarcinoma according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
11,3,7,12-Tetrahydroxycholan-24-oic acid2410.7FABP6, ABCC3, SLC10A2
21,3,12-Trihydroxycholan-24-oic acid2410.7FABP6, ABCC3, SLC10A2
3(3a,5b,7a)-23-Carboxy-7-hydroxy-24-norcholan-3-yl-b-D-Glucopyranosiduronic acid2410.7FABP6, ABCC3, SLC10A2
4bromosulfophthalein4510.6GSTP1, ABCC3
5Taurocholic Acid11 2411.6SLC10A2, ABCC3, FABP6
6deoxycholic acid45 29 11 2413.6SLC10A2, ABCC3, FABP6
7bile acid4510.6AKR1C2, ABCC3
8fluorouracil50 1111.6ABCC3, ERCC2, GSTP1
9hydrocarbons4510.6GSTP1, ERCC2, AKR1C2
10bcnu4510.6GSTP1, ERCC2, SOD2
11gamma-glutamylcysteine45 11 2412.6GSTP1, ABCC3, SOD2
12aclarubicin4510.6MYB, GSTP1
13platinum compounds5010.6ERCC2, GSTP1
14taurocholate4510.6FABP6, ABCC3, SLC10A2
15cholic acid45 29 11 2413.6FABP6, ABCC3, SLC10A2
16glutathion4510.6SOD2, GSTP1
17lithocholic acid45 29 2412.6FABP6, AKR1C2, ABCC3, SLC10A2
18Glutathione11 2411.6GSTP1, ABCC3, GPX2
19ursodeoxycholic acid45 11 2412.6FABP6, AKR1C2, ABCC3, SLC10A2
20chenodeoxycholic acid45 29 11 2413.6FABP6, AKR1C2, ABCC3, SLC10A2
21aldose4510.6SOD2, AKR1B10, AKR1C2
22butyrate4510.6MYB, SOD2
23adriamycin4510.5SOD2, ABCC3, TERC, GSTP1
24glycocholate4510.5FABP6, ABCC3
25sulfinpyrazone45 1111.5GSTP1, ABCC3
26dmso4510.5SOD2, MYB, TERC, GSTP1
27cyclophosphamide45 50 1112.5GSTP1, ERCC2, ABCC3, SOD2
284-hydroxynonenal45 2411.5SOD2, MYB, GSTP1
29folate4510.5SOD2, ABCC3, ERCC2, GSTP1
305fluorouracil4510.5SOD2, TERC, ERCC2, GSTP1
31methotrexate45 50 1112.5GSTP1, ERCC2, ABCC3, SOD2
32etoposide45 50 60 1113.5GSTP1, TERC, ABCC3, SOD2
33doxorubicin45 50 1112.4SOD2, MYB, ABCC3, TERC, GSTP1
3412-o-tetradecanoylphorbol 13-acetate4510.4MSR1, MYB, SOD2, TIMP3
35mk 57145 6011.4GSTP1, ABCC3
36cisplatin45 50 60 1113.4SOD2, AKR1C2, ABCC3, TERC, ERCC2, GSTP1
37vincristine45 50 1112.3GSTP1, ERCC2, ABCC3
38retinoic acid45 2411.3TIMP3, MYB, GPX2, ABCC3, SLC10A2, TERC
39progesterone45 60 29 11 2414.3TERC, MYB, DKK1, AKR1C2, TIMP3
40testosterone45 60 11 2413.2TIMP3, SOD2, AKR1C2, MSR1, GSTP1
41cholesterol45 29 11 2413.2FABP6, ABCC3, SLC10A2, MSR1, ERCC2
42dehydroascorbic acid45 1111.2GSTP1, SOD2
43paraffin4510.1GSTP1, TERC, SOD2, TIMP3
44dexamethasone45 50 29 1113.0TIMP3, SOD2, MYB, ABCC3, SLC10A2
45lipid4510.0MSR1, TIMP3, SOD2, FABP6, PKP1, MYB
46docetaxel45 50 60 1112.9SLC10A2, ERCC2, GSTP1

GO Terms for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Barrett Esophagus/esophageal Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:00558110.3MSR1, CTHRC1, C1QA

Biological processes related to Barrett Esophagus/esophageal Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1doxorubicin metabolic processGO:04459810.3AKR1C2, AKR1B10
2bile acid and bile salt transportGO:01572110.2SLC10A2, ABCC3, FABP6
3bile acid metabolic processGO:00820610.1FABP6, ABCC3, SLC10A2
4daunorubicin metabolic processGO:04459710.0AKR1C2, AKR1B10

Products for genes affiliated with Barrett Esophagus/esophageal Adenocarcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Barrett Esophagus/esophageal Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet