MCID: BRR002
MIFTS: 36

Barrett's Adenocarcinoma malady

Summaries for Barrett's Adenocarcinoma

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33MalaCards
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MalaCards: Barrett's Adenocarcinoma, also known as adenocarcinoma arising in barrett's mucosa, is related to oral cancer and cataract. An important gene associated with Barrett's Adenocarcinoma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Nucleotide Excision Repair and Vitamin C (ascorbate) metabolism. The compounds Vitamin E and 1-chloro-24-dinitrobenzene have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and endothelial, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Barrett's Adenocarcinoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Aliases & Descriptions:

barrett's adenocarcinoma 8 61
adenocarcinoma arising in barrett's mucosa 8


External Ids:

Disease Ontology8 DOID:7941
NCIt40 C7027

Related Diseases for Barrett's Adenocarcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer10.0GSTM3, S100A2
2cataract10.0GSTM3, GPX1
3hepatitis b10.0GPX1, ERCC2
4stomach cancer10.0SOCS1, XRCC1, XRCC3
5multiple sclerosis10.0SOCS1, SOCS3
6atherosclerosis10.0GSTA4, GPX1, SOCS3
7laryngeal carcinoma10.0GSTM3, ERCC2, XRCC1
8pancreatic cancer10.0S100A2, SOCS1, XRCC1
9hepatocellular carcinoma10.0SOCS1, SOCS3, XPC, GSTA4
10skin cancer10.0XRCC1, XRCC3, XPC, ERCC2
11adenoma10.0XRCC1, XRCC3, ERCC2, GSTA4
12myeloid leukemia10.0SOCS1, SOCS3
13basal cell carcinoma10.0S100A2, XRCC1, XRCC3, ERCC2, GSTM3
14ovarian cancer10.0GSTO2, ERCC2
15cervical cancer10.0XRCC1
16bladder carcinoma in situ10.0XRCC1, XRCC3, XPC, ERCC2, GSTA4
17astrocytoma10.0GSTM3, ERCC2, XPC
18xeroderma pigmentosum10.0XRCC1, XRCC3, XPC, ERCC2
19asthma10.0GSTA4, GPX1, SOCS3, SOCS1
20bladder carcinoma10.0XRCC1, XRCC3, XPC, GPX1, ERCC2, GSTM3
21adenocarcinoma10.0ERCC2, S100A2, SOCS1, SOCS3, XRCC1, XRCC3
22parkinson's disease10.0GPX1, GSTA4, GSTO2, GSTO1
23photosensitive trichothiodystrophy10.0ERCC2, XPC
24non-small cell lung carcinoma10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC
25leukemia10.0SOCS1, SOCS3, XRCC1, GPX1, ERCC2, GSTA4
26lung benign neoplasm10.0ERCC2, XPC, XRCC1
27colorectal cancer10.0SOCS1, SOCS3, XRCC1, XRCC3, XPC, ERCC2
28squamous cell carcinoma10.0S100A2, SOCS1, XRCC1, XRCC3, XPC, GPX1
29alzheimer's disease10.0GSTO1, GSTO2
30melanoma10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC
31lung cancer10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC
32prostate cancer10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC
33breast cancer10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC

Graphical network of the top 20 diseases related to Barrett's Adenocarcinoma:



Diseases related to barrett's adenocarcinoma

Clinical Features for Barrett's Adenocarcinoma

Drugs & Therapeutics for Barrett's Adenocarcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Barrett's Adenocarcinoma

Anatomical Context for Barrett's Adenocarcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Barrett's Adenocarcinoma:

33
Bone marrow, Small intestine, Endothelial

Animal Models for Barrett's Adenocarcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Barrett's Adenocarcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5GSTO1, SOX7, SOCS1, SOCS3, XRCC1, XPC

Publications for Barrett's Adenocarcinoma

Sources:
51PubMed
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Articles related to Barrett's Adenocarcinoma:

(show top 50)    (show all 173)
idTitleAuthorsYear
1
Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region. (23617667)
2013
2
Endoscopic management of Barrett's esophagus with high-grade dysplasia and early-stage esophageal adenocarcinoma. (24199698)
2013
3
Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma. (21820152)
2012
4
Dysfunctional transforming growth factor-I^ signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. (21898377)
2012
5
Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma. (22129558)
2012
6
p16 gene mutations in Barrett's esophagus in gastric metaplasia - intestinal metaplasia - dysplasia - adenocarcinoma sequence. (22440936)
2012
7
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. (22537613)
2012
8
Genes of the interleukin-18 pathway are associated with susceptibility to Barrett's esophagus and esophageal adenocarcinoma. (22664470)
2012
9
Genome-wide DNA methylation profiling of cell-free serum DNA in esophageal adenocarcinoma and Barrett esophagus. (22355271)
2012
10
Repetitive sequences, genomic instability and Barrett's esophageal adenocarcinoma. (22479688)
2011
11
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. (21423218)
2011
12
How much length of the distal esophagus is removed by transhiatal approach for squamous cell carcinoma and Barrett's adenocarcinoma in Japanese patients? (22234066)
2011
13
Expression of the putative stem cell marker Musashi-1 in Barrett's esophagus and esophageal adenocarcinoma. (20459440)
2010
14
Risk of esophageal adenocarcinoma and mortality in patients with Barrett's esophagus: a systematic review and meta-analysis. (19850156)
2010
15
Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett's esophagus. (20188100)
2010
16
A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. (20947487)
2010
17
Iron intake and markers of iron status and risk of Barrett's esophagus and esophageal adenocarcinoma. (20936528)
2010
18
Nonsteroidal anti-inflammatory drugs and esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence: a meta-analysis. (21166737)
2010
19
Homogeneous EGFR amplification defines a subset of aggressive Barrett's adenocarcinomas with poor prognosis. (20840671)
2010
20
Barrett's adenocarcinoma 52 years after subtotal esophagectomy for pediatric peptic stricture. (20103354)
2010
21
Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. (19147768)
2009
22
Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis. (19222528)
2009
23
Evaluation of fatty acid synthase expression in oesophageal mucosa of patients with oesophagitis, Barrett's oesophagus and adenocarcinoma. (19471962)
2009
24
MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus. (19342367)
2009
25
STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. (17947454)
2008
26
Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus. (18261624)
2008
27
Sorafenib inhibits MAPK-mediated proliferation in a Barrett's esophageal adenocarcinoma cell line. (18840136)
2008
28
Glycine-extended gastrin stimulates proliferation via JAK2- and Akt-dependent NF-kappaB activation in Barrett's oesophageal adenocarcinoma cells. (18771702)
2008
29
Small cell carcinoma with concomitant adenocarcinoma arising in a Barrett's oesophagus: report of a case with a favourable behaviour. (18008084)
2008
30
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. (17185078)
2007
31
Mucin expression profile in Barrett's, dysplasia, adenocarcinoma sequence in the esophagus. (17401217)
2007
32
Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expression. (17636545)
2007
33
Esophageal adenocarcinoma arising from Barrett's dysplasia: a case report of double occurrence and prolonged survival after chemotherapy. (16988098)
2006
34
Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activation. (16740977)
2006
35
Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus. (17085323)
2006
36
p53 Protein expression from mild dysplasia to adenocarcinoma in a patient with Barrett's esophagus: an immunohistochemical study]. (17049004)
2006
37
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. (16172218)
2005
38
The 'angiogenic switch' in the progression from Barrett's metaplasia to esophageal adenocarcinoma. (14624783)
2003
39
Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus. (12855631)
2003
40
Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. (11316217)
2001
41
Oncogene amplification and genetic heterogeneity in the metaplasia-dysplasia-adenocarcinoma sequence of Barrett esophagus]. (11894407)
2001
42
Long-term survival of a patient with widespread metastases from Barrett's adenocarcinoma. (11504525)
2001
43
The evolution of loss of heterozygosity on chromosome 17 during the progression to barrett's adenocarcinoma involves a unique combination of target sites in individual specimens. (11051253)
2000
44
Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. (10702199)
2000
45
Genetic versus environmental interactions in the oesophagitis-metaplasia-dysplasia-adenocarcinoma sequence (MCS) of Barrett's oesophagus. (10907314)
2000
46
Expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) and p53 tumor suppressor in dysplastic progression and adenocarcinoma in Barrett esophagus. (10463972)
1999
47
Is Barrett's esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study. (9409571)
1997
48
Detection of genetic changes in Barrett's adenocarcinoma and Barrett's esophagus by DNA in situ hybridization and immunohistochemistry. (8168405)
1994
49
p53 protein expression in Barrett's adenocarcinoma: a frequent event with no prognostic significance. (8088724)
1994
50
Adenocarcinoma in situ of Barrett's esophagus diagnosed by endoscopic cytology. (4411868)
1974

Genetic Variations for Barrett's Adenocarcinoma

Expression for genes affiliated with Barrett's Adenocarcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Barrett's Adenocarcinoma

Search GEO for disease gene expression data for Barrett's Adenocarcinoma.

Pathways for genes affiliated with Barrett's Adenocarcinoma

Sources:
54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Barrett's Adenocarcinoma

Sources:
11DrugBank, 45Novoseek, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1Vitamin E1110.3GSTO1, GSTM3
21-chloro-24-dinitrobenzene4510.3GSTO1, GSTO2, GSTM2
3epoxide4510.3XRCC1, GSTM2, GSTM3
4hydrochloric acid45 2411.0GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
5adrenochrome45 2411.0GSTM3, GSTA4, GSTO2, GSTO1, GSTM5, GSTM2
6noradrenochrome45 2411.0GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
7platinum compounds5010.0ERCC2, XRCC1
8cisplatin45 50 60 1113.0XRCC1, XRCC3, XPC, ERCC2, GSTM3
9sulfate45 2410.9GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
10gsts459.9XRCC1, GPX1, GSTT2, GSTZ1, GSTM2, GSTM3
11Glutathione11 2410.9GSTO1, GSTO2, GPX1, GSTT2, GSTZ1, GSTM2
12tyrosine459.7S100A2, S100A10, SOCS1, SOCS3, XRCC1, XPC

GO Terms for genes affiliated with Barrett's Adenocarcinoma

Sources:
16Gene Ontology
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Cellular components related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.6GSTO1, SOCS3, GPX1, GSTZ1, GSTM2, GSTM5

Biological processes related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.6GSTM3, GSTM2
2cellular detoxification of nitrogen compoundGO:07045810.5GSTM3, GSTM2
3cellular response to arsenic-containing substanceGO:07124310.5GSTO1, GSTO2
4regulation of mitotic cell cycle phase transitionGO:190199010.5XPC, ERCC2
5xenobiotic catabolic processGO:04217810.5GSTM2, GSTM3, GSTO1
6L-ascorbic acid metabolic processGO:01985210.5GSTO1, GSTO2
7positive regulation of ryanodine-sensitive calcium-release channel activityGO:06031610.5GSTO1, GSTM2
8negative regulation of ryanodine-sensitive calcium-release channel activityGO:06031510.4GSTM2, GSTO1
9UV protectionGO:00965010.4ERCC2, GPX1
10nucleotide-excision repair, DNA damage removalGO:00071810.3ERCC2, XPC
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:01088010.3GSTM2, GSTO1
12glutathione metabolic processGO:00674910.2GPX1, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
13DNA repairGO:00628110.2ERCC2, XPC, XRCC3, XRCC1
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:01088110.2GSTO1, GSTM2
15glutathione derivative biosynthetic processGO:190168710.2GSTO1, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
16xenobiotic metabolic processGO:00680510.2GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4, GSTO2
17regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0SOCS3, SOCS1
18small molecule metabolic processGO:04428110.0GPX1, ERCC2, GSTZ1, GSTM2, GSTM5, GSTM3

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methylarsonate reductase activityGO:05061010.4GSTO2, GSTO1
2glutathione dehydrogenase (ascorbate) activityGO:04517410.3GSTO2, GSTO1
3protein kinase inhibitor activityGO:00486010.3SOCS3, SOCS1
4glutathione bindingGO:04329510.2GSTM3, GSTM2
5glutathione peroxidase activityGO:00460210.0GSTZ1, GPX1
6glutathione transferase activityGO:0043649.9GSTO1, GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3

Products for genes affiliated with Barrett's Adenocarcinoma

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Sources for Barrett's Adenocarcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet