MCID: BRR002
MIFTS: 33

Barrett's Adenocarcinoma malady

Cancer diseases category
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Summaries for Barrett's Adenocarcinoma

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MalaCards based summary: Barrett's Adenocarcinoma, also known as adenocarcinoma arising in barrett's mucosa, is related to adenocarcinoma and esophagitis. An important gene associated with Barrett's Adenocarcinoma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Defective BTD causes biotidinase deficiency and Chemical carcinogenesis. The compounds vitamin e and 1-chloro-24-dinitrobenzene have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and heart.

Aliases & Classifications for Barrett's Adenocarcinoma

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Barrett's Adenocarcinoma, Aliases & Descriptions:

Name: Barrett's Adenocarcinoma 8 62
Adenocarcinoma Arising in Barrett's Mucosa 8 62
 
Barrett Adenocarcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:7941
NCIt39 C7027

Related Diseases for Barrett's Adenocarcinoma

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Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma10.4
2esophagitis10.3

Symptoms for Barrett's Adenocarcinoma

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Drugs & Therapeutics for Barrett's Adenocarcinoma

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Drug clinical trials:

Search ClinicalTrials for Barrett's Adenocarcinoma

Search NIH Clinical Center for Barrett's Adenocarcinoma

Genetic Tests for Barrett's Adenocarcinoma

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Anatomical Context for Barrett's Adenocarcinoma

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MalaCards organs/tissues related to Barrett's Adenocarcinoma:

32
Bone, Lymph node, Heart, Endothelial

Animal Models for Barrett's Adenocarcinoma or affiliated genes

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Publications for Barrett's Adenocarcinoma

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Articles related to Barrett's Adenocarcinoma:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Ischemic heart disease, factor predisposing to Barrett's adenocarcinoma: A case control study. (25133047)
2014
2
Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth. (23604115)
2013
3
Barrett's adenocarcinoma in long-segment Barrett's esophagus successfully detected by narrow-band imaging with magnifying endoscopy. (23617678)
2013
4
Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region. (23617667)
2013
5
Small Barrett's adenocarcinoma, 3 mm in size, in long-segment Barrett's esophagus detected after 4 years of follow up. (23617677)
2013
6
A second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model. (23288782)
2013
7
Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma. (23180947)
2012
8
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. (22365974)
2012
9
Barrett's adenocarcinoma of the esophagus: better outcomes through new methods of diagnosis and treatment. (21629515)
2011
10
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. (21423218)
2011
11
Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. (20677919)
2011
12
How much length of the distal esophagus is removed by transhiatal approach for squamous cell carcinoma and Barrett's adenocarcinoma in Japanese patients? (22234066)
2011
13
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. (18664505)
2009
14
Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. (19828957)
2009
15
No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. (18349297)
2008
16
Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. (18202808)
2008
17
Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma. (18513411)
2008
18
Results of a multimodal therapy in patients with stage IV Barrett's adenocarcinoma. (18802733)
2008
19
Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. (17376806)
2007
20
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. (17185078)
2007
21
Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor. (16720317)
2006
22
NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin. (17244951)
2006
23
Overexpression of TGF-beta1 in esophageal (Barrett's) adenocarcinoma is associated with advanced stage of disease and poor prognosis. (16921482)
2006
24
Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. (16022731)
2005
25
Allelic imbalance on distal 7q (7q36.1-q36.3) in gastric cardia and oesophageal (Barrett's) adenocarcinoma. (15868927)
2005
26
Esophageal (Barrett's) adenocarcinoma is not associated with Epstein-Barr virus infection: an analysis of 162 cases. (15929074)
2005
27
Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. (16077942)
2005
28
MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro. (15964304)
2005
29
Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma. (15221937)
2004
30
Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. (15231484)
2004
31
INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma. (15185075)
2004
32
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. (15107828)
2004
33
Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. (15585388)
2004
34
Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line. (15300175)
2004
35
Results of surgical therapy in patients with Barrett's adenocarcinoma. (12917757)
2003
36
Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro. (12524396)
2003
37
Incipient angiogenesis in Barrett's epithelium and lymphangiogenesis in Barrett's adenocarcinoma. (12089227)
2002
38
Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence. (10666385)
2000
39
Molecular genetic changes in metastatic primary Barrett's adenocarcinoma and related lymph node metastases: comparison with nonmetastatic Barrett's adenocarcinoma. (10912943)
2000
40
Prevalence of Helicobacter pylori infection in 160 patients with Barrett's oesophagus or Barrett's adenocarcinoma. (10696939)
2000
41
The evolution of loss of heterozygosity on chromosome 17 during the progression to barrett's adenocarcinoma involves a unique combination of target sites in individual specimens. (11051253)
2000
42
Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett's esophagus, Barrett's dysplasia, and Barrett's adenocarcinoma. (10685740)
2000
43
Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. (10445576)
1999
44
Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines. (10078940)
1999
45
Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridization. (10419593)
1999
46
Epidemiology and molecular biology of Barrett's adenocarcinoma. (9229415)
1997
47
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma. (8829627)
1996
48
Expression and clinical significance of the AgNOR and PCNA in Barrett's adenocarcinoma and its precancerous lesions]. (7587897)
1995
49
Expression of c-erbB-2 oncogene product in Barrett's adenocarcinoma: pathological and prognostic correlations. (7907608)
1994
50
Detection of genetic changes in Barrett's adenocarcinoma and Barrett's esophagus by DNA in situ hybridization and immunohistochemistry. (8168405)
1994

Variations for Barrett's Adenocarcinoma

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Expression for genes affiliated with Barrett's Adenocarcinoma

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Expression patterns in normal tissues for genes affiliated with Barrett's Adenocarcinoma

Search GEO for disease gene expression data for Barrett's Adenocarcinoma.

Pathways for genes affiliated with Barrett's Adenocarcinoma

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Pathways related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
9.0GSTO2, GSTO1
2
Show member pathways
8.1GSTM3, GSTO1, GSTO2, GSTT2
3
Show member pathways
7.6GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
4
Show member pathways
7.6GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
5
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
7.6GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3

Compounds for genes affiliated with Barrett's Adenocarcinoma

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Sources:
50PharmGKB, 11DrugBank, 44Novoseek, 24HMDB
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Compounds related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin e50 1110.1GSTO1, GSTM3
21-chloro-24-dinitrobenzene448.7GSTO2, GSTO1
3noradrenochrome44 248.9GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
44-Hydroxyestrone-2-S-glutathione247.9GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
5Estrone-2,3-quinone247.9GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
6Estrone-3,4-quinone247.9GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
7S-(PGJ2)-glutathione247.9GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
82-Hydroxyestrone-1-S-glutathione247.8GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
92-Hydroxyestrone-4-S-glutathione247.8GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
10hydrochloric acid44 248.8GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
11adrenochrome44 248.8GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3
12gsts447.7GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
13Glutathione24 118.7GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
14sulfate44 248.6GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
15Water247.1COX7A2, GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1

GO Terms for genes affiliated with Barrett's Adenocarcinoma

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Cellular components related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0GSTZ1, GSTO2, GSTO1, GSTM3

Biological processes related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glutathione metabolic processGO:0067499.3GSTZ1, GSTM3
2oxidation-reduction processGO:0551149.3GSTZ1, GSTO2
3xenobiotic catabolic processGO:0421789.2GSTO1, GSTM3
4cellular response to arsenic-containing substanceGO:0712439.1GSTO1, GSTO2
5L-ascorbic acid metabolic processGO:0198529.0GSTO2, GSTO1
6glutathione derivative biosynthetic processGO:19016878.2GSTZ1, GSTO2, GSTO1, GSTM3
7xenobiotic metabolic processGO:0068058.1GSTM3, GSTO1, GSTO2, GSTZ1
8small molecule metabolic processGO:0442817.7GSTM3, GSTO1, GSTO2, GSTZ1

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.0GSTO2, GSTO1
2methylarsonate reductase activityGO:0506108.9GSTO1, GSTO2
3glutathione dehydrogenase (ascorbate) activityGO:0451748.7GSTO1, GSTO2
4glutathione transferase activityGO:0043647.6GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3

Products for genes affiliated with Barrett's Adenocarcinoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Barrett's Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet