MCID: BRR002
MIFTS: 33

Barrett's Adenocarcinoma malady

Cancer diseases category

Summaries for Barrett's Adenocarcinoma

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34MalaCards
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MalaCards: Barrett's Adenocarcinoma, also known as adenocarcinoma arising in barrett's mucosa, is related to adenocarcinoma and esophagitis. An important gene associated with Barrett's Adenocarcinoma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Defective BTD causes biotidinase deficiency and Chemical carcinogenesis. The compounds vitamin e and 1-chloro-24-dinitrobenzene have been mentioned in the context of this disorder. Affiliated tissues include bone, lymph node and endothelial.

Aliases & Classifications for Barrett's Adenocarcinoma

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Sources:
9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

barrett's adenocarcinoma 9 63
adenocarcinoma arising in barrett's mucosa 9
barrett adenocarcinoma 9


External Ids:

Disease Ontology9 DOID:7941
NCIt41 C7027

Related Diseases for Barrett's Adenocarcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma10.4
2esophagitis10.3

Symptoms for Barrett's Adenocarcinoma

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Drugs & Therapeutics for Barrett's Adenocarcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Barrett's Adenocarcinoma

Drug clinical trials:

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Search NIH Clinical Center for Barrett's Adenocarcinoma

Search CenterWatch for Barrett's Adenocarcinoma

Genetic Tests for Barrett's Adenocarcinoma

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Anatomical Context for Barrett's Adenocarcinoma

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34MalaCards
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MalaCards organs/tissues related to Barrett's Adenocarcinoma:

34
Bone, Lymph node, Endothelial

Animal Models for Barrett's Adenocarcinoma or affiliated genes

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Publications for Barrett's Adenocarcinoma

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53PubMed
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Articles related to Barrett's Adenocarcinoma:

(show top 50)    (show all 87)
idTitleAuthorsYear
1
Targeting homologous recombination and telomerase in Barrett's adenocarcinoma: impact on telomere maintenance, genomic instability and tumor growth. (23604115)
2013
2
Barrett's adenocarcinoma in long-segment Barrett's esophagus successfully detected by narrow-band imaging with magnifying endoscopy. (23617678)
2013
3
Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region. (23617667)
2013
4
Small Barrett's adenocarcinoma, 3 mm in size, in long-segment Barrett's esophagus detected after 4 years of follow up. (23617677)
2013
5
A second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model. (23288782)
2013
6
Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma. (23180947)
2012
7
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma. (22365974)
2012
8
Barrett's adenocarcinoma of the esophagus: better outcomes through new methods of diagnosis and treatment. (21629515)
2011
9
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. (21423218)
2011
10
Human Barrett's adenocarcinoma of the esophagus, associated myofibroblasts, and endothelium can arise from bone marrow-derived cells after allogeneic stem cell transplant. (20677919)
2011
11
How much length of the distal esophagus is removed by transhiatal approach for squamous cell carcinoma and Barrett's adenocarcinoma in Japanese patients? (22234066)
2011
12
A case of early Barrett's adenocarcinoma repeatedly developing multiple metachronous lesions shortly after endoscopic therapy: an analysis for genetic and epigenetic alterations. (20650453)
2010
13
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. (18664505)
2009
14
Differences in the definitions used for esophageal and gastric diseases in different countries: endoscopic definition of the esophagogastric junction, the precursor of Barrett's adenocarcinoma, the definition of Barrett's esophagus, and histologic criteria for mucosal adenocarcinoma or high-grade dysplasia. (19828957)
2009
15
No association between hOGG1, XRCC1, and XPD polymorphisms and risk of reflux esophagitis, Barrett's esophagus, or esophageal adenocarcinoma: results from the factors influencing the Barrett's adenocarcinoma relationship case-control study. (18349297)
2008
16
Corn-derived carbohydrate inositol hexaphosphate inhibits Barrett's adenocarcinoma growth by pro-apoptotic mechanisms. (18202808)
2008
17
Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma. (18513411)
2008
18
Results of a multimodal therapy in patients with stage IV Barrett's adenocarcinoma. (18802733)
2008
19
Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma. (17376806)
2007
20
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. (17185078)
2007
21
Angiogenic switch in Barrett's adenocarcinoma: the role of vascular endothelial growth factor. (16720317)
2006
22
NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin. (17244951)
2006
23
Overexpression of TGF-beta1 in esophageal (Barrett's) adenocarcinoma is associated with advanced stage of disease and poor prognosis. (16921482)
2006
24
Familial Barrett's adenocarcinoma. (16542304)
2006
25
Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. (16022731)
2005
26
Allelic imbalance on distal 7q (7q36.1-q36.3) in gastric cardia and oesophageal (Barrett's) adenocarcinoma. (15868927)
2005
27
Esophageal (Barrett's) adenocarcinoma is not associated with Epstein-Barr virus infection: an analysis of 162 cases. (15929074)
2005
28
Mucin expression and proliferating cell index of esophageal Barrett's adenocarcinoma. (16077942)
2005
29
MAPK and PI3K inhibition reduces proliferation of Barrett's adenocarcinoma in vitro. (15964304)
2005
30
Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinoma. (15221937)
2004
31
Acid increases proliferation via ERK and p38 MAPK-mediated increases in cyclooxygenase-2 in Barrett's adenocarcinoma cells. (15231484)
2004
32
INK4a-ARF alterations in Barrett's epithelium, intraepithelial neoplasia and Barrett's adenocarcinoma. (15185075)
2004
33
A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. (15107828)
2004
34
Quantitative, tissue-specific analysis of cyclooxygenase gene expression in the pathogenesis of Barrett's adenocarcinoma. (15585388)
2004
35
Bile salt exposure causes phosphatidyl-inositol-3-kinase-mediated proliferation in a Barrett's adenocarcinoma cell line. (15300175)
2004
36
Results of surgical therapy in patients with Barrett's adenocarcinoma. (12917757)
2003
37
Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro. (12524396)
2003
38
Incipient angiogenesis in Barrett's epithelium and lymphangiogenesis in Barrett's adenocarcinoma. (12089227)
2002
39
Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence. (10666385)
2000
40
Molecular genetic changes in metastatic primary Barrett's adenocarcinoma and related lymph node metastases: comparison with nonmetastatic Barrett's adenocarcinoma. (10912943)
2000
41
Prevalence of Helicobacter pylori infection in 160 patients with Barrett's oesophagus or Barrett's adenocarcinoma. (10696939)
2000
42
The evolution of loss of heterozygosity on chromosome 17 during the progression to barrett's adenocarcinoma involves a unique combination of target sites in individual specimens. (11051253)
2000
43
Prospective evaluation of the prevalence of gastric Helicobacter pylori infection in patients with GERD, Barrett's esophagus, Barrett's dysplasia, and Barrett's adenocarcinoma. (10685740)
2000
44
Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. (10445576)
1999
45
Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines. (10078940)
1999
46
Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridization. (10419593)
1999
47
Epidemiology and molecular biology of Barrett's adenocarcinoma. (9229415)
1997
48
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma. (8829627)
1996
49
Expression and clinical significance of the AgNOR and PCNA in Barrett's adenocarcinoma and its precancerous lesions]. (7587897)
1995
50
Expression of c-erbB-2 oncogene product in Barrett's adenocarcinoma: pathological and prognostic correlations. (7907608)
1994

Variations for Barrett's Adenocarcinoma

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Expression for genes affiliated with Barrett's Adenocarcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Barrett's Adenocarcinoma

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Pathways for genes affiliated with Barrett's Adenocarcinoma

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 52PharmGKB
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Pathways related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
flavin biosynthesis IV (mammalian)39
molybdenum cofactor biosynthesis39
coenzyme A biosynthesis39
thiamin salvage III39
alanine biosynthesis III39
thio-molybdenum cofactor biosynthesis39
biotin-carboxyl carrier protein assembly39
9.0GSTO1, GSTO2
2
Show member pathways
8.1GSTM3, GSTT2, GSTO2, GSTO1
3
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
7.6GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
4
Show member pathways
7.6GSTZ1, GSTM3, GSTO1, GSTO2, GSTT2
5
Show member pathways
7.6GSTO2, GSTO1, GSTT2, GSTZ1, GSTM3

Compounds for genes affiliated with Barrett's Adenocarcinoma

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Sources:
52PharmGKB, 12DrugBank, 46Novoseek, 25HMDB
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Compounds related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1vitamin e52 1210.1GSTM3, GSTO1
21-chloro-24-dinitrobenzene468.7GSTO1, GSTO2
3S-(PGJ2)-glutathione257.9GSTM3, GSTO1, GSTT2, GSTZ1, GSTO2
44-Hydroxyestrone-2-S-glutathione257.9GSTO2, GSTT2, GSTZ1, GSTO1, GSTM3
52-Hydroxyestrone-4-S-glutathione257.9GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
62-Hydroxyestrone-1-S-glutathione257.9GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
7Estrone-2,3-quinone257.9GSTZ1, GSTM3, GSTO1, GSTO2, GSTT2
8Estrone-3,4-quinone257.8GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1
9noradrenochrome46 258.8GSTT2, GSTZ1, GSTO2, GSTO1, GSTM3
10hydrochloric acid46 258.8GSTT2, GSTZ1, GSTM3, GSTO2, GSTO1
11adrenochrome46 258.8GSTT2, GSTO1, GSTM3, GSTZ1, GSTO2
12gsts467.7GSTT2, GSTZ1, GSTO2, GSTO1, GSTM3
13Glutathione25 128.7GSTM3, GSTO2, GSTZ1, GSTT2, GSTO1
14sulfate46 258.6GSTO1, GSTO2, GSTT2, GSTZ1, GSTM3
15Water257.1GSTM3, GSTO1, GSTO2, GSTT2, GSTZ1, COX7A2

GO Terms for genes affiliated with Barrett's Adenocarcinoma

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17Gene Ontology
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Cellular components related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058298.0GSTZ1, GSTO2, GSTO1, GSTM3

Biological processes related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1glutathione metabolic processGO:0067499.3GSTZ1, GSTM3
2oxidation-reduction processGO:0551149.3GSTZ1, GSTO2
3xenobiotic catabolic processGO:0421789.2GSTO1, GSTM3
4cellular response to arsenic-containing substanceGO:0712439.1GSTO1, GSTO2
5L-ascorbic acid metabolic processGO:0198529.0GSTO2, GSTO1
6glutathione derivative biosynthetic processGO:19016878.2GSTM3, GSTZ1, GSTO2, GSTO1
7xenobiotic metabolic processGO:0068058.1GSTO2, GSTO1, GSTZ1, GSTM3
8small molecule metabolic processGO:0442817.7GSTM3, GSTO1, GSTZ1, GSTO2

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activityGO:0164919.0GSTO1, GSTO2
2methylarsonate reductase activityGO:0506108.9GSTO2, GSTO1
3glutathione dehydrogenase (ascorbate) activityGO:0451748.7GSTO1, GSTO2
4glutathione transferase activityGO:0043647.6GSTZ1, GSTT2, GSTO2, GSTO1, GSTM3

Products for genes affiliated with Barrett's Adenocarcinoma

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Sources for Barrett's Adenocarcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet