MCID: BRR002
MIFTS: 41

Barrett's Adenocarcinoma malady

Summaries for Barrett's Adenocarcinoma

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32MalaCards
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MalaCards: Barrett's Adenocarcinoma, also known as adenocarcinoma arising in barrett's mucosa, is related to oral cancer and cataract. An important gene associated with Barrett's Adenocarcinoma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Nucleotide Excision Repair and Vitamin C (ascorbate) metabolism. The compounds Vitamin E and 1-chloro-24-dinitrobenzene have been mentioned in the context of this disorder. Affiliated tissues include lymph node, endothelial and bone, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Barrett's Adenocarcinoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

barrett's adenocarcinoma 8 60
adenocarcinoma arising in barrett's mucosa 8


External Ids:

Disease Ontology8 DOID:7941
NCIt39 C7027

Related Diseases for Barrett's Adenocarcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Barrett's Adenocarcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 32)
idRelated DiseaseScoreTop Affiliating Genes
1oral cancer10.0GSTM3, S100A2
2cataract10.0GPX1, GSTM3
3hepatitis b10.0GPX1, ERCC2
4stomach cancer10.0XRCC3, XRCC1, SOCS1
5multiple sclerosis10.0SOCS1, SOCS3
6atherosclerosis10.0GSTA4, GPX1, SOCS3
7laryngeal benign neoplasm10.0GSTM3, XRCC1, ERCC2
8pancreatic cancer10.0XRCC1, S100A2, SOCS1
9hepatocellular carcinoma10.0SOCS1, XPC, GSTA4, SOCS3
10adenoma10.0GSTA4, XRCC1, ERCC2, XRCC3
11myeloid leukemia10.0SOCS3, SOCS1
12ovarian cancer10.0GSTO2, ERCC2
13basal cell carcinoma10.0S100A2, XRCC1, XRCC3, ERCC2, GSTM3
14cervical cancer10.0XRCC1
15astrocytoma10.0GSTM3, ERCC2, XPC
16bladder carcinoma in situ10.0XPC, GSTA4, ERCC2, XRCC3, XRCC1
17xeroderma pigmentosum10.0ERCC2, XRCC3, XRCC1, XPC
18asthma10.0GPX1, SOCS3, SOCS1, GSTA4
19bladder carcinoma10.0GPX1, XRCC1, XRCC3, XPC, ERCC2, GSTM3
20adenocarcinoma10.0XRCC1, S100A2, SOCS1, SOCS3, XRCC3, XPC
21parkinson's disease10.0GSTO1, GSTO2, GSTA4, GPX1
22photosensitive trichothiodystrophy10.0ERCC2, XPC
23non-small cell lung carcinoma10.0XPC, S100A2, SOCS1, SOCS3, XRCC1, XRCC3
24leukemia10.0GSTA4, SOCS3, GPX1, ERCC2, XRCC1, SOCS1
25lung benign neoplasm10.0ERCC2, XPC, XRCC1
26colorectal cancer10.0GSTA4, GSTM3, SOCS1, SOCS3, XRCC1, XRCC3
27squamous cell carcinoma10.0S100A2, XPC, GPX1, ERCC2, GSTM3, SOCS1
28alzheimer's disease10.0GSTO1, GSTO2
29melanoma10.0S100A2, SOCS1, SOCS3, XRCC1, XRCC3, XPC
30lung cancer10.0XRCC3, GPX1, ERCC2, XRCC1, SOCS3, SOCS1
31prostate cancer10.0SOCS1, S100A2, SOCS3, XRCC1, XRCC3, XPC
32breast cancer10.0XPC, GPX1, ERCC2, GSTM2, XRCC3, GSTA4

Graphical network of the top 20 diseases related to Barrett's Adenocarcinoma:



Diseases related to barrett's adenocarcinoma

Clinical Features for Barrett's Adenocarcinoma

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Drugs & Therapeutics for Barrett's Adenocarcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Barrett's Adenocarcinoma

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Anatomical Context for Barrett's Adenocarcinoma

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32MalaCards
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MalaCards organs/tissues related to Barrett's Adenocarcinoma:

32
Lymph node, Endothelial, Bone, Liver

Animal Models for Barrett's Adenocarcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Barrett's Adenocarcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.5GSTO1, SOX7, SOCS1, SOCS3, XRCC1, XPC

Publications for Barrett's Adenocarcinoma

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50PubMed
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Articles related to Barrett's Adenocarcinoma:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Invasion of poorly differentiated adenocarcinoma to the deep muscularis mucosae may be an indicator of lymph node metastasis in Barrett's esophageal cancer. (23617671)
2013
2
Current status of endoscopic diagnosis and treatment of superficial Barrett's adenocarcinoma in Asia-Pacific region. (23617667)
2013
3
Transcriptionally active human papillomavirus is strongly associated with Barrett's dysplasia and esophageal adenocarcinoma. (23588239)
2013
4
Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux. (24168968)
2013
5
Screening and risk stratification for Barrett's esophagus: how to limit the clinical impact of the increasing incidence of esophageal adenocarcinoma. (23452636)
2013
6
Management of high-grade dysplasia and intramucosal adenocarcinoma in Barrett's esophagus. (22507878)
2012
7
Fluorescence in situ hybridization mapping of esophagectomy specimens from patients with Barrett's esophagus with high-grade dysplasia or adenocarcinoma. (21820152)
2012
8
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process. (22537613)
2012
9
Longer inspection time is associated with increased detection of high-grade dysplasia and esophageal adenocarcinoma in Barrett's esophagus. (22732877)
2012
10
Increased expression of the 5-lipoxygenase pathway and its cellular localization in Barrett's adenocarcinoma. (22690932)
2012
11
Progression to adenocarcinoma in Barrett's esophagus after liver transplantation. (21464795)
2011
12
Barrett's adenocarcinoma of the esophagus: better outcomes through new methods of diagnosis and treatment. (21629515)
2011
13
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome. (21423218)
2011
14
Comparison between endoscopic and surgical resection of mucosal esophageal adenocarcinoma in Barrett's esophagus at two high-volume centers. (21532466)
2011
15
The incidence of esophageal adenocarcinoma in Barrett's esophagus has been overestimated. (21731021)
2011
16
Barrett's esophagus: treatments of adenocarcinomas I. (21950817)
2011
17
Expression of the putative stem cell marker Musashi-1 in Barrett's esophagus and esophageal adenocarcinoma. (20459440)
2010
18
A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. (20947487)
2010
19
Nonsteroidal anti-inflammatory drugs and esophageal inflammation - Barrett's esophagus - adenocarcinoma sequence: a meta-analysis. (21166737)
2010
20
Expression of C1q complement component in Barrett's esophagus and esophageal adenocarcinoma. (20496011)
2010
21
Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence]. (19606680)
2009
22
Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays. (18663352)
2009
23
Altered expression of CD44 and DKK1 in the progression of Barrett's esophagus to esophageal adenocarcinoma. (19396460)
2009
24
Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation. (19153190)
2009
25
Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. (17849424)
2008
26
Comparison of DNA histograms by standard flow cytometry and image cytometry on sections in Barrett's adenocarcinoma. (18513411)
2008
27
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma. (18396902)
2008
28
Patient preferences for the chemoprevention of esophageal adenocarcinoma in Barrett's esophagus. (18775019)
2008
29
Esophageal adenocarcinoma arising from Barrett's epithelium in Taiwan. (17711800)
2007
30
Extent of low-grade dysplasia is a risk factor for the development of esophageal adenocarcinoma in Barrett's esophagus. (17338734)
2007
31
Increasing expression of hypoxia-inducible proteins in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. (17437013)
2007
32
Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. (16521222)
2006
33
Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus. (16863542)
2006
34
p53 Protein expression from mild dysplasia to adenocarcinoma in a patient with Barrett's esophagus: an immunohistochemical study]. (17049004)
2006
35
The molecular signature of normal squamous esophageal epithelium identifies the presence of a field effect and can discriminate between patients with Barrett's esophagus and patients with Barrett's-associated adenocarcinoma. (16172218)
2005
36
Telomerase, hTERT and splice variants in Barrett's oesophagus and oesophageal adenocarcinoma. (15674101)
2005
37
Neuroendocrine in Barrett's mucosa and adenocarcinomas of the gastroesophageal junction. (15173916)
2004
38
In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line. (15046208)
2004
39
Results of surgical therapy in patients with Barrett's adenocarcinoma. (12917757)
2003
40
Histological features pertinent to local tumour progression in Barrett's adenocarcinoma. (12926155)
2003
41
The utility of cytokeratin subsets in distinguishing Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma. (11318895)
2001
42
HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma. (10665910)
2000
43
Prospective study of cyclin D1 overexpression in Barrett's esophagus: association with increased risk of adenocarcinoma. (10944553)
2000
44
Cyclooxygenase-2 in Barrett's esophagus, Barrett's adenocarcinomas, and esophageal SCC: ready for clinical trials. (10445576)
1999
45
Second primary Barrett's adenocarcinoma after 19 years. (10391301)
1999
46
Molecular analysis of the TP53 gene in Barrett's adenocarcinoma. (8829627)
1996
47
Frequent loss of heterozygosity on chromosome 17 at 17q11.2-q12 in Barrett's adenocarcinoma. (7734326)
1995
48
Prognostic value of DNA ploidy and c-erbB-2 oncoprotein overexpression in adenocarcinoma of Barrett's esophagus. (7907940)
1994
49
Expression of c-erbB-2 oncogene product in Barrett's adenocarcinoma: pathological and prognostic correlations. (7907608)
1994
50
Adenocarcinoma in situ of Barrett's esophagus diagnosed by endoscopic cytology. (4411868)
1974

Genetic Variations for Barrett's Adenocarcinoma

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Expression for genes affiliated with Barrett's Adenocarcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Barrett's Adenocarcinoma

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Pathways for genes affiliated with Barrett's Adenocarcinoma

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53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Barrett's Adenocarcinoma

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11DrugBank, 44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1Vitamin E1110.3GSTO1, GSTM3
21-chloro-24-dinitrobenzene4410.3GSTO1, GSTO2, GSTM2
3epoxide4410.3XRCC1, GSTM2, GSTM3
4hydrochloric acid44 2411.0GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
5adrenochrome44 2411.0GSTM3, GSTA4, GSTO2, GSTO1, GSTM5, GSTM2
6noradrenochrome44 2411.0GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
7platinum compounds4910.0ERCC2, XRCC1
8cisplatin44 49 59 1113.0XRCC1, XRCC3, XPC, ERCC2, GSTM3
9sulfate44 2410.9GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
10gsts449.9XRCC1, GPX1, GSTT2, GSTZ1, GSTM2, GSTM3
11Glutathione11 2410.9GSTO1, GSTO2, GPX1, GSTT2, GSTZ1, GSTM2
12tyrosine449.7S100A2, S100A10, SOCS1, SOCS3, XRCC1, XPC

GO Terms for genes affiliated with Barrett's Adenocarcinoma

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16Gene Ontology
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Cellular components related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:0058299.6GSTO1, SOCS3, GPX1, GSTZ1, GSTM2, GSTM5

Biological processes related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1nitrobenzene metabolic processGO:01891610.6GSTM3, GSTM2
2cellular detoxification of nitrogen compoundGO:07045810.5GSTM3, GSTM2
3cellular response to arsenic-containing substanceGO:07124310.5GSTO1, GSTO2
4regulation of mitotic cell cycle phase transitionGO:190199010.5XPC, ERCC2
5xenobiotic catabolic processGO:04217810.5GSTM2, GSTM3, GSTO1
6L-ascorbic acid metabolic processGO:01985210.5GSTO1, GSTO2
7positive regulation of ryanodine-sensitive calcium-release channel activityGO:06031610.5GSTO1, GSTM2
8negative regulation of ryanodine-sensitive calcium-release channel activityGO:06031510.4GSTM2, GSTO1
9UV protectionGO:00965010.4ERCC2, GPX1
10nucleotide-excision repair, DNA damage removalGO:00071810.3ERCC2, XPC
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:01088010.3GSTM2, GSTO1
12glutathione metabolic processGO:00674910.2GPX1, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
13DNA repairGO:00628110.2ERCC2, XPC, XRCC3, XRCC1
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGO:01088110.2GSTO1, GSTM2
15glutathione derivative biosynthetic processGO:190168710.2GSTO1, GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4
16xenobiotic metabolic processGO:00680510.2GSTZ1, GSTM2, GSTM5, GSTM3, GSTA4, GSTO2
17regulation of interferon-gamma-mediated signaling pathwayGO:06033410.0SOCS3, SOCS1
18small molecule metabolic processGO:04428110.0GPX1, ERCC2, GSTZ1, GSTM2, GSTM5, GSTM3

Molecular functions related to Barrett's Adenocarcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1methylarsonate reductase activityGO:05061010.4GSTO2, GSTO1
2glutathione dehydrogenase (ascorbate) activityGO:04517410.3GSTO2, GSTO1
3protein kinase inhibitor activityGO:00486010.3SOCS3, SOCS1
4glutathione bindingGO:04329510.2GSTM3, GSTM2
5glutathione peroxidase activityGO:00460210.0GSTZ1, GPX1
6glutathione transferase activityGO:0043649.9GSTO1, GSTT2, GSTZ1, GSTM2, GSTM5, GSTM3

Products for genes affiliated with Barrett's Adenocarcinoma

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Sources for Barrett's Adenocarcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet