CLE
MCID: BRR003
MIFTS: 62

Barrett's Esophagus (CLE) malady

Gastrointestinal, Cancer categories

Summaries for Barrett's Esophagus

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Barrett syndrome, also known as barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. this process is called intestinal metaplasia. the exact cause of barrett syndrome is not known, but gastroesophageal reflux disease (gerd) is a risk factor for the condition. while barrett syndrome itself does not cause symptoms, the acid reflux associated with gerd often leads to symptoms of heartburn.  less than 1% of people with barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. treatment of gerd should improve symptoms, and may keep barrett syndrome from getting worse. endoscopic or surgical treatments can be used to treat barrett syndrome with severe dysplasia or cancer. last updated: 3/5/2010

MalaCards: Barrett's Esophagus, also known as barrett esophagus, is related to adenocarcinoma and gastric ulcer. An important gene associated with Barrett's Esophagus is CTHRC1 (collagen triple helix repeat containing 1), and among its related pathways is O-linked glycosylation of mucins. The drugs sodium bicarbonate and sodium bicarbonate powder and the compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone marrow and small intestine, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:64 Barrett esophagus (British English: Barrett\'s oesophagus), sometimes called Barrett syndrome or... more...

Aliases & Classifications for Barrett's Esophagus

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

barrett's esophagus 8
barrett esophagus 8 43 20 22 45 61
barrett's ulcer of esophagus 8 61
chronic peptic ulcer and esophagitis syndrome 43
barrett's esophagus with esophagitis 8
gastroesophageal reflux disease 61
peptic ulcer of esophagus 61
esophagitis-peptic ulcer 43
columnar-like esophagus 43
ulcerative esophagitis 8
barrett's oesophagus 8
esophageal carcinoma 61
barretts esophagus 10
barretts syndrome 8
barrett syndrome 43
barrett ulcer 43
cle 8


External Ids:

Disease Ontology8 DOID:9206
MeSH35 D001471
ICD9CM27 530.85
NCIt40 C2891
ICD1025 K22.7

Related Diseases for Barrett's Esophagus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Barrett's Esophagus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.2MUC2, MUC6, MUC5AC, MUC3B, CDKN2A, CDX2
2gastric ulcer30.6GAST, TFF1, TFF2, TFF3, MUC5AC
3duodenal ulcer30.4MUC6, TFF1, GAST
4squamous cell carcinoma30.2AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
5cystic fibrosis30.2AMACR, MUC2, MUC6, MUC5AC, MUC3B, SI
6hepatitis c30.2AMACR
7tubular adenocarcinoma30.2MUC2, MUC5AC, CDX2, KRT7, KRT20
8bile reflux30.2TFF1
9leukoplakia29.9MKI67, TERC
10hypercalcemia29.9GAST
11barrett esophagus/esophageal adenocarcinoma10.8
12eosinophilic esophagitis10.7
13dyspepsia10.7
14asthma10.6
15irritable bowel syndrome10.6
16morbid obesity10.5
17barrett's adenocarcinoma10.5
18tooth disease10.5
19devic disease10.5
20tooth erosion10.5
21sleep apnea10.5
22bruxism10.4
23m�ni�re disease10.4
24pulmonary function10.4
25pulmonary disease, chronic obstructive10.4
26prune belly syndrome10.4
27esophageal atresia10.4
28bronchiolitis obliterans10.3
29bronchiolitis10.3
30arthritis10.3
31autonomic neuropathy10.3
32tongue disease10.3
33chronic hiccups10.3
34swallowing disorders10.3
35gastroesophageal reflux disease10.3
36mungan syndrome10.3
37high-grade dysplasia in patients with barrett esophagus10.3
38cutaneous lupus erythematosus10.3
39eagle syndrome10.2
40bone carcinoma10.2
41tylosis with esophageal cancer10.2
42dysphagia10.2
43esophageal squamous cell carcinoma10.2
44diabetic nephropathy10.2
45parkinson's disease10.2
46major depressive disorder10.2
47menkes disease10.2
48xerophthalmia10.2
49idiopathic pulmonary fibrosis10.2
50chagas disease10.2

Graphical network of the top 20 diseases related to Barrett's Esophagus:



Diseases related to barrett's esophagus

Clinical Features for Barrett's Esophagus

Genetic Tests for Barrett's Esophagus

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Barrett's Esophagus:

id Genetic test Affiliating Genes
1 Barrett Esophagus20
2 Barrett's Esophagus22

Anatomical Context for Barrett's Esophagus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Barrett's Esophagus:

33
Lymph node, Bone marrow, Small intestine

Animal Models for Barrett's Esophagus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Barrett's Esophagus

Sources:
51PubMed
See all sources

Articles related to Barrett's Esophagus:

(show top 50)    (show all 365)
idTitleAuthorsYear
1
Association Between Helicobacter pylori and Barrett's Esophagus, Erosive Esophagitis, and Gastroesophageal Reflux Symptoms. (23988686)
2014
2
Barrett's esophagus is frequently overdiagnosed in clinical practice: results of the Barrett's Esophagus Endoscopic Revision (BEER) study. (24262638)
2013
3
Barrett's esophagus surveillance: time to rethink if one size fits all? (23891612)
2013
4
Recurrence of subsquamous dysplasia and carcinoma after successful endoscopic and radiofrequency ablation therapy for dysplastic Barrett's esophagus. (23592390)
2013
5
Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett's esophagus: A pilot ex-vivo study. (24379583)
2013
6
Statins are associated with reduced risk of esophageal cancer, particularly in patients with Barrett's esophagus: a systematic review and meta-analysis. (23357487)
2013
7
Subsquamous Extension of Intestinal Metaplasia Is Detected in 98% of Cases of Neoplastic Barrett's Esophagus. (23891922)
2013
8
Endoscopic assessment and grading of Barrett's esophagus using magnification endoscopy and narrow band imaging: impact of structured learning and experience on the accuracy of the Amsterdam classification system. (23215965)
2013
9
Adiponectin and leptin receptors expression in Barrett's esophagus and normal squamous epithelium in relation to central obesity status. (23756394)
2013
10
Intestinal metaplasia recurs infrequently in patients successfully treated for Barrett's esophagus with radiofrequency ablation. (23247578)
2013
11
Barrett's esophagus and the risk of obstructive sleep apnea: a case-control study. (23663216)
2013
12
MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma. (23466817)
2013
13
Clinical utility and interobserver agreement of autofluorescence imaging and magnification narrow-band imaging for the evaluation of Barrett's esophagus: a prospective tandem study. (23433595)
2013
14
Radiofrequency ablation for long- and ultralong-segment Barrett's esophagus: a comparative long-term follow-up study. (23290719)
2013
15
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. (24121790)
2013
16
Remission of Barrett's esophagus with early neoplasia 5 years after radiofrequency ablation with endoscopic resection: a Netherlands cohort study. (23542068)
2013
17
Efficacy and durability of radiofrequency ablation for Barrett's Esophagus: systematic review and meta-analysis. (23644385)
2013
18
Health benefits and cost effectiveness of endoscopic and nonendoscopic cytosponge screening for Barrett's esophagus. (23041329)
2013
19
Obstructive Sleep Apnea and Environmental Contributors for Barrett's Esophagus. (24161348)
2013
20
Markers suggest reduced malignant potential of subsquamous intestinal metaplasia compared with Barrett's esophagus. (23796148)
2013
21
Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. (22715394)
2012
22
Focal endoscopic mucosal resection before radiofrequency ablation is equally effective and safe compared with radiofrequency ablation alone for the eradication of Barrett's esophagus with advanced neoplasia. (22732872)
2012
23
Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus. (22844273)
2012
24
Laparoscopic treatment of obese patients with gastroesophageal reflux disease and Barrett's esophagus: a prospective study. (22392129)
2012
25
Acid suppression increases rates of Barrett's esophagus and esophageal injury in the presence of duodenal reflux. (22019500)
2012
26
Mortality in Barrett's esophagus: three decades of experience at a single center. (22752886)
2012
27
Esophageal manometry findings and degree of acid exposure in short and long Barrett's esophagus. (22481688)
2012
28
Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus. (23064761)
2012
29
Circumferential location predicts the risk of high-grade dysplasia and early adenocarcinoma in short-segment Barrett's esophagus. (22381529)
2012
30
Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barrett's esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD. (22944288)
2012
31
A pilot study of endoscopic spray cryotherapy by pressurized carbon dioxide gas for Barrett's esophagus. (21437849)
2011
32
Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis. (20651033)
2010
33
Expression of the putative stem cell marker Musashi-1 in Barrett's esophagus and esophageal adenocarcinoma. (20459440)
2010
34
Changes in screening, prognosis and therapy for esophageal adenocarcinoma in Barrett's esophagus. (19461512)
2009
35
Esophageal disease. Screening and surveillance for Barrett's esophagus: esophageal capsule versus conventional endoscopy. (18477971)
2008
36
Ski/SnoN expression in the sequence metaplasia-dysplasia-adenocarcinoma of Barrett's esophagus. (18261624)
2008
37
Bile acid-stimulated expression of the farnesoid X receptor enhances the immune response in Barrett esophagus. (18510604)
2008
38
What is the clinical significance of stromal angiogenesis in Barrett's esophagus? (19120900)
2008
39
Proteomic screening of a cell line model of esophageal carcinogenesis identifies cathepsin D and aldo-keto reductase 1C2 and 1B10 dysregulation in Barrett's esophagus and esophageal adenocarcinoma. (18396902)
2008
40
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. (17185078)
2007
41
Targeting the Wnt signaling pathway to treat Barrett's esophagus. (17298295)
2007
42
Predictors for squamous re-epithelialization of Barrett's esophagus after endoscopic biopsy. (17565646)
2007
43
Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma. (17236199)
2007
44
Expression of survivin, p53, and caspase 3 in Barrett's esophagus carcinogenesis. (16360411)
2006
45
High-grade dysplasia and superficial adenocarcinoma in Barrett's esophagus: histological mapping and expression of p53, p21 and Bcl-2 oncoproteins. (12536310)
2003
46
Does chemoprevention of Barrett's esophagus using acid suppression and/or COX-2 inhibition prevent neoplastic progression? (12478242)
2002
47
Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression. (10419913)
1999
48
Expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) and p53 tumor suppressor in dysplastic progression and adenocarcinoma in Barrett esophagus. (10463972)
1999
49
Flow cytometric DNA analysis and p53 protein expression show a good correlation with histologic findings in patients with Barrett's esophagus. (9708926)
1998
50
Chemopreventive studies in Barrett's esophagus: a model premalignant lesion for esophageal adenocarcinoma. (1389696)
1992

Genetic Variations for Barrett's Esophagus

Expression for genes affiliated with Barrett's Esophagus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Barrett's Esophagus

Search GEO for disease gene expression data for Barrett's Esophagus.

Pathways for genes affiliated with Barrett's Esophagus

Sources:
54Reactome
See all sources

Pathways related to Barrett's Esophagus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7MUC3B, MUC5AC, MUC6, MUC2

Compounds for genes affiliated with Barrett's Esophagus

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Barrett's Esophagus according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1paraffin4511.7AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
2progesterone45 60 29 11 2415.6MUC2, MKI67, TFF3, TFF1, AMACR, MUC6
3tyrosine4511.5AMACR, GAST, TFF3, MKI67, MUC5AC, MUC3B
4retinoic acid45 2412.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
5cysteine4511.4AMACR, TFF1, TFF3, MUC2, MUC5AC, CDKN2A
6calcium45 50 11 2414.4AMACR, GAST, TFF1, TFF2, MKI67, MUC2
7hematoxylin4511.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
8testosterone45 60 11 2414.4AMACR, GAST, TFF1, MKI67, MUC5AC, CDKN2A
9oligonucleotide4511.4AMACR, MUC2, MUC6, MUC5AC, MUC3B, CDKN2A
10glucose4511.4AMACR, GAST, TFF1, MUC2, MUC5AC, CDKN2A
11methotrexate45 50 1113.3TFF3, MKI67, MUC2, MUC5AC, CDKN2A, SI
125fluorouracil4511.2MKI67, MUC2, MUC6, MUC5AC, CDKN2A, TERC
13vegf4511.2GAST, TFF1, TFF3, MKI67, CDKN2A, KRT7
14dexamethasone45 50 29 1114.2AMACR, TFF1, MUC2, MUC5AC, CDKN2A, SI
15thymidine45 2412.2GAST, TFF1, MKI67, CDX2, SI, TERC
16fatty acid4511.1AMACR, TFF1, CDKN2A, CDX2, SI
17cholesterol45 29 11 2414.1AMACR, MUC2, MUC6, MUC5AC, CDKN2A, SI
18lipid4511.1AMACR, MKI67, CDKN2A, GPX2, SI, KRT7
19steroid4511.1TFF1, TFF3, MKI67, MUC5AC, CDKN2A, CDX2
20streptavidin4511.1AMACR, MKI67, KRT7, KRT20
21carbohydrates4511.1MKI67, MUC2, MUC5AC, SI
22ethanol45 50 11 2414.1TFF1, TFF3, MKI67, MUC5AC, SI
23cesium chloride45 6012.0MUC5AC, MUC2, TFF1
24butyrate4511.0SI, CDX2
255-aza-2deoxycytidine4511.0MUC2, CDKN2A, CDX2, KRT7
26deoxycholic acid45 29 11 2414.0SI, CDX2, MUC2
27estrogen4511.0SI
28methanol45 2411.9KRT7, CDKN2A, MKI67
29tamoxifen45 50 29 1113.9TFF1, TFF3, MKI67, TERC
30h2o24510.9TFF1, TFF3, CDKN2A, GPX2, SI
31polysaccharide4510.8KRT7, SI, MUC5AC, MUC6
32triiodothyronine4510.8SI, MUC5AC, GAST
33actinomycin d4510.7CDKN2A, MUC2, TFF3, TFF1
34biotin45 11 2412.7AMACR, MKI67, CDKN2A
35doxorubicin45 50 1112.6TERC, KRT20, CDKN2A, MKI67
36mucicarmine4510.3KRT7, KRT20

GO Terms for genes affiliated with Barrett's Esophagus

Sources:
16Gene Ontology
See all sources

Cellular components related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.7MUC3B, MUC5AC, MUC6, MUC2

Biological processes related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.7MUC5AC, TFF3, TFF2, TFF1
2O-glycan processingGO:01626610.6MUC2, MUC6, MUC5AC, MUC3B
3maintenance of gastrointestinal epitheliumGO:03027710.6MUC6, TFF1
4post-translational protein modificationGO:04368710.4MUC3B, MUC5AC, MUC6, MUC2

Products for genes affiliated with Barrett's Esophagus

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Sources for Barrett's Esophagus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet