CLE
MCID: BRR003
MIFTS: 68

Barrett's Esophagus (CLE) malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Barrett's Esophagus

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Barrett syndrome, also known as barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. this process is called intestinal metaplasia. the exact cause of barrett syndrome is not known, but gastroesophageal reflux disease (gerd) is a risk factor for the condition. while barrett syndrome itself does not cause symptoms, the acid reflux associated with gerd often leads to symptoms of heartburn.  less than 1% of people with barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. treatment of gerd should improve symptoms, and may keep barrett syndrome from getting worse. endoscopic or surgical treatments can be used to treat barrett syndrome with severe dysplasia or cancer. last updated: 3/5/2010

MalaCards: Barrett's Esophagus, also known as barrett esophagus, is related to adenocarcinoma and gastric ulcer. An important gene associated with Barrett's Esophagus is CTHRC1 (collagen triple helix repeat containing 1), and among its related pathways is O-linked glycosylation of mucins. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone and liver, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:63 Barrett esophagus (British English: Barrett\'s oesophagus), sometimes called Barrett syndrome or... more...

Aliases & Classifications for Barrett's Esophagus

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8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

barrett's esophagus 8
barrett esophagus 8 42 20 22 44 60
barrett's ulcer of esophagus 8 60
chronic peptic ulcer and esophagitis syndrome 42
barrett's esophagus with esophagitis 8
gastroesophageal reflux disease 60
peptic ulcer of esophagus 60
esophagitis-peptic ulcer 42
columnar-like esophagus 42
ulcerative esophagitis 8
barrett's oesophagus 8
esophageal carcinoma 60
barretts esophagus 10
barretts syndrome 8
barrett syndrome 42
barrett ulcer 42
cle 8


External Ids:

Disease Ontology8 DOID:9206
MeSH34 D001471
ICD9CM27 530.85
NCIt39 C2891
ICD1025 K22.7

Related Diseases for Barrett's Esophagus

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17GeneCards, 18GeneDecks
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Diseases related to Barrett's Esophagus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1MUC2, MUC6, MUC5AC, MUC3B, CDKN2A, CDX2
2gastric ulcer30.5GAST, TFF1, TFF2, TFF3, MUC5AC
3duodenitis30.5GAST
4duodenal ulcer30.4MUC6, TFF1, GAST
5esophagitis30.3CDX2, GAST
6squamous cell carcinoma30.2AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
7cystic fibrosis30.2AMACR, MUC2, MUC6, MUC5AC, MUC3B, SI
8otitis media30.2MUC5AC
9gastric adenocarcinoma30.1GAST, TFF1, MUC2, CDX2, KRT7, KRT20
10tubular adenocarcinoma30.1MUC2, MUC5AC, CDX2, KRT7, KRT20
11bile reflux30.1TFF1
12gastritis29.9TERC, CDX2, GAST
13peptic ulcer29.9MUC5AC, GAST
14hepatocellular carcinoma29.9AMACR, TFF3, MKI67, MUC2, MUC5AC, CDKN2A
15lung cancer29.9AMACR, TFF1, MUC2, MUC5AC, CDKN2A, CDX2
16lung adenocarcinoma29.9AMACR, MUC5AC, CDKN2A, CDX2, KRT7, KRT20
17transitional cell carcinoma29.8MKI67, KRT7, KRT20, TERC
18papilloma29.8MUC2, MUC5AC
19hepatitis29.8AMACR
20hypercalcemia29.8GAST
21esophagus adenocarcinoma10.8
22eosinophilic esophagitis10.7
23dyspepsia10.7
24laryngeal disease10.6
25laryngitis10.6
26asthma10.6
27irritable bowel syndrome10.5
28morbid obesity10.5
29hiatus hernia10.5
30barrett's adenocarcinoma10.5
31tooth disease10.5
32barrett esophagus/esophageal adenocarcinoma10.5
33diabetes mellitus10.4
34tooth erosion10.4
35esophageal cancer10.4
36bruxism10.4
37diabetic neuropathy10.4
38duodenal disease10.4
39movement disease10.4
40neuropathy10.4
41esophageal atresia10.3
42peptic esophagitis10.3
43bronchiolitis obliterans10.3
44bronchiolitis10.3
45coats disease10.3
46diabetic autonomic neuropathy10.3
47arthritis10.3
48autonomic neuropathy10.3
49rheumatoid arthritis10.3
50tongue disease10.3

Graphical network of the top 20 diseases related to Barrett's Esophagus:



Diseases related to barrett's esophagus

Clinical Features for Barrett's Esophagus

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Genetic Tests for Barrett's Esophagus

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20GeneTests, 22GTR
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Genetic tests related to Barrett's Esophagus:

id Genetic test Affiliating Genes
1 Barrett Esophagus20
2 Barrett's Esophagus22

Anatomical Context for Barrett's Esophagus

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32MalaCards
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MalaCards organs/tissues related to Barrett's Esophagus:

32
Lymph node, Bone, Liver, Testes

Animal Models for Barrett's Esophagus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Barrett's Esophagus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.2TERC, GAST, TFF1, TFF2, TFF3, MUC2
2MP:000537611.2TFF2, TFF3, MUC2, MUC5AC, CDX2, RETNLB
3MP:000537910.9TERC, GPX2, CDKN2A, MUC2, TFF2, GAST
4MP:000200610.8CDX2, CDKN2A, TFF1, GAST, MUC2, TERC
5MP:000538710.7TERC, GPX2, RETNLB, CDKN2A, MUC5AC, TFF3

Publications for Barrett's Esophagus

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50PubMed
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Articles related to Barrett's Esophagus:

(show top 50)    (show all 821)
idTitleAuthorsYear
1
Assessment of Mutational Load in Biopsy Tissue Provides Additional Information About Genomic Instability to Histological Classifications of Barrett's Esophagus. (24402860)
2014
2
Role of interleukin-6 in Barrett's esophagus pathogenesis. (23613623)
2013
3
Association between markers of obesity and progression from Barrett's esophagus to esophageal adenocarcinoma. (23466711)
2013
4
Safety of endoscopic mucosal resection for Barrett's esophagus. (23857478)
2013
5
Optical coherence tomography in Barrett's esophagus. (23735102)
2013
6
Small Barrett's adenocarcinoma, 3 mm in size, in long-segment Barrett's esophagus detected after 4 years of follow up. (23617677)
2013
7
Esophageal motility and impedance characteristics in patients with Barrett's esophagus before and after radiofrequency ablation. (23708277)
2013
8
Photodynamic Therapy for Barrett's Esophagus and Esophageal Carcinoma. (23423151)
2013
9
Predictable Marker for Regression of Barrett's Esophagus by Proton Pump Inhibitor Treatment in Korea. (23667752)
2013
10
Cigarette smoking and the risk of Barrett's esophagus: a systematic review and meta-analysis. (23611750)
2013
11
Adenocarcinoma arising from short-segment Barrett's esophagus in a young man. (23617676)
2013
12
Radiofrequency ablation for Barrett's esophagus, for whom and by whom? (23811256)
2013
13
Barrett's esophagus: cancer and molecular biology. (24117650)
2013
14
Laparoscopic Nissen fundoplication in the treatment of Barrett's esophagus - 10 years of experience. (23837098)
2013
15
Health benefits and cost effectiveness of endoscopic and nonendoscopic cytosponge screening for Barrett's esophagus. (23041329)
2013
16
Cause-specific mortality of people with Barrett's esophagus compared with the general population: a population-based cohort study. (23583429)
2013
17
A combination of esomeprazole and aspirin reduces tissue concentrations of prostaglandin E(2) in patients with Barrett's esophagus. (22796132)
2012
18
p16 gene mutations in Barrett's esophagus in gastric metaplasia - intestinal metaplasia - dysplasia - adenocarcinoma sequence. (22440936)
2012
19
The effect of reactive atypia/inflammation on the laser-induced fluorescence diagnosis of non-dysplastic Barrett's esophagus. (22535652)
2012
20
Subsquamous intestinal metaplasia: implications for endoscopic management of Barrett's esophagus. (22020059)
2012
21
Mortality in Barrett's esophagus: three decades of experience at a single center. (22752886)
2012
22
Cancer risk from Barrett's esophagus lower than thought. (22550738)
2012
23
Endoscopic submucosal dissection plus radiofrequency ablation of neoplastic Barrett's esophagus. (22968641)
2012
24
Clinical implications of molecular changes in pediatric Barrett's esophagus. (22373715)
2012
25
Probe-Based Confocal Laser Endomicroscopy to Guide Real-Time Endoscopic Therapy in Barrett's Esophagus with Dysplasia. (22754488)
2012
26
Risk factors for neoplastic progression in Barrett's esophagus. (21990948)
2011
27
Purification of diseased cells from Barrett's esophagus and related lesions by laser capture microdissection. (21761303)
2011
28
Dysplastic Barrett's esophagus in cirrhosis: a treatment dilemma. (21897417)
2011
29
Incidence of adenocarcinoma among patients with Barrett's esophagus. (21995385)
2011
30
Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma. (21977915)
2011
31
Risk factors for Barrett's esophagus in Indian patients with gastroesophageal reflux disease. (21375585)
2011
32
Evaluation of difluoromethylornithine for the chemoprevention of Barrett's esophagus and mucosal dysplasia. (21636549)
2011
33
Immunoreactivity of cytokeratins 7 and 20 in goblet cells and columnar blue cells in patients with endoscopic evidence of Barrett's esophagus. (19578614)
2009
34
Expression of EpCam and villin in Barrett's esophagus and in gastric cardia. (18688077)
2008
35
Esophageal disease. Screening and surveillance for Barrett's esophagus: esophageal capsule versus conventional endoscopy. (18477971)
2008
36
Expression analysis of Barrett's esophagus-associated high-grade dysplasia in laser capture microdissected archival tissue. (18927283)
2008
37
Small cell carcinoma arising in Barrett's esophagus: a case report and review of the literature. (18211708)
2008
38
Esophageal adenocarcinoma and Barrett's esophagus. (17557044)
2007
39
Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance. (17932229)
2007
40
The clinical, pathological features and expression of Ki-67 and COX-2 in severe reflux esophagitis and Barrett's esophagus]. (15807268)
2005
41
Zoning of mucosal phenotype, dysplasia, and telomerase activity measured by telomerase repeat assay protocol in Barrett's esophagus. (15068673)
2004
42
Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett's) metaplasia. (15167938)
2004
43
P53 protein and malignant progression in Barrett's metaplasia (Barrett's esophagus). (12809848)
2003
44
Barrett's esophagus: chemoprevention. (14629099)
2003
45
Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. (11016622)
2000
46
Cytokeratin immunoreactivity patterns in the diagnosis of short-segment Barrett's esophagus. (10982762)
2000
47
Cytokeratin subsets can reliably distinguish Barrett's esophagus from intestinal metaplasia of the stomach. (10088547)
1999
48
Molecular alterations in Barrett's esophagus and adenocarcinoma]. (10379532)
1999
49
Suppression of apoptosis does not foster neoplastic growth in Barrett's esophagus. (10102608)
1999
50
Expression of CD44 variant proteins in adenocarcinoma of Barrett's esophagus and its relation to prognosis. (9740070)
1998

Genetic Variations for Barrett's Esophagus

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Expression for genes affiliated with Barrett's Esophagus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Barrett's Esophagus

Search GEO for disease gene expression data for Barrett's Esophagus.

Pathways for genes affiliated with Barrett's Esophagus

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53Reactome
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Pathways related to Barrett's Esophagus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7MUC3B, MUC5AC, MUC6, MUC2

Compounds for genes affiliated with Barrett's Esophagus

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Barrett's Esophagus according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1paraffin4411.7AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
2progesterone44 59 28 11 2415.6MUC2, MKI67, TFF3, TFF1, AMACR, MUC6
3tyrosine4411.5AMACR, GAST, TFF3, MKI67, MUC5AC, MUC3B
4retinoic acid44 2412.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
5cysteine4411.4AMACR, TFF1, TFF3, MUC2, MUC5AC, CDKN2A
6calcium44 49 11 2414.4AMACR, GAST, TFF1, TFF2, MKI67, MUC2
7hematoxylin4411.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
8testosterone44 59 11 2414.4AMACR, GAST, TFF1, MKI67, MUC5AC, CDKN2A
9oligonucleotide4411.4AMACR, MUC2, MUC6, MUC5AC, MUC3B, CDKN2A
10glucose4411.4AMACR, GAST, TFF1, MUC2, MUC5AC, CDKN2A
11methotrexate44 49 1113.3TFF3, MKI67, MUC2, MUC5AC, CDKN2A, SI
125fluorouracil4411.2MKI67, MUC2, MUC6, MUC5AC, CDKN2A, TERC
13vegf4411.2GAST, TFF1, TFF3, MKI67, CDKN2A, KRT7
14dexamethasone44 49 28 1114.2AMACR, TFF1, MUC2, MUC5AC, CDKN2A, SI
15thymidine44 2412.2GAST, TFF1, MKI67, CDX2, SI, TERC
16fatty acid4411.1AMACR, TFF1, CDKN2A, CDX2, SI
17cholesterol44 28 11 2414.1AMACR, MUC2, MUC6, MUC5AC, CDKN2A, SI
18lipid4411.1AMACR, MKI67, CDKN2A, GPX2, SI, KRT7
19steroid4411.1TFF1, TFF3, MKI67, MUC5AC, CDKN2A, CDX2
20streptavidin4411.1AMACR, MKI67, KRT7, KRT20
21carbohydrates4411.1MKI67, MUC2, MUC5AC, SI
22ethanol44 49 11 2414.1TFF1, TFF3, MKI67, MUC5AC, SI
23cesium chloride44 5912.0MUC5AC, MUC2, TFF1
24butyrate4411.0SI, CDX2
255-aza-2deoxycytidine4411.0MUC2, CDKN2A, CDX2, KRT7
26deoxycholic acid44 28 11 2414.0SI, CDX2, MUC2
27estrogen4411.0SI
28methanol44 2411.9KRT7, CDKN2A, MKI67
29tamoxifen44 49 28 1113.9TFF1, TFF3, MKI67, TERC
30h2o24410.9TFF1, TFF3, CDKN2A, GPX2, SI
31polysaccharide4410.8KRT7, SI, MUC5AC, MUC6
32triiodothyronine4410.8SI, MUC5AC, GAST
33actinomycin d4410.7CDKN2A, MUC2, TFF3, TFF1
34biotin44 11 2412.7AMACR, MKI67, CDKN2A
35doxorubicin44 49 1112.6TERC, KRT20, CDKN2A, MKI67
36mucicarmine4410.3KRT7, KRT20

GO Terms for genes affiliated with Barrett's Esophagus

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16Gene Ontology
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Cellular components related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.7MUC3B, MUC5AC, MUC6, MUC2

Biological processes related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.7MUC5AC, TFF3, TFF2, TFF1
2O-glycan processingGO:01626610.6MUC2, MUC6, MUC5AC, MUC3B
3maintenance of gastrointestinal epitheliumGO:03027710.6MUC6, TFF1
4post-translational protein modificationGO:04368710.4MUC3B, MUC5AC, MUC6, MUC2

Products for genes affiliated with Barrett's Esophagus

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Sources for Barrett's Esophagus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet