Barrett's Esophagus malady

Wikipedia: Barrett esophagus (British English: Barrett\'s oesophagus), sometimes called Barrett syndrome or...⁴⁴ more...

MalaCards: Barrett's Esophagus, also known as barrett esophagus, is related to gastric adenocarcinoma and esophagus adenocarcinoma. An important gene associated with Barrett's Esophagus is CTHRC1 (collagen triple helix repeat containing 1), and among its related pathways are Signal transduction_PTEN pathway and Apoptosis and survival Role of CDK5 in neuronal death and survival. The drugs magnesium hydroxide and sodium bicarbonate and the compounds h2o2 and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, t cells and b cells, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

barrett's esophagus 6 barrett esophagus 6 16 32 43 barrett's esophagus with esophagitis (disorder) 6 barrett's ulcer of esophagus (disorder) 6 adenocarcinoma of esophagus (disorder) 16 gastroesophageal reflux disease 43 barrett's esophagus (disorder) 6 barrett's ulcer of esophagus 43 peptic ulcer of esophagus 43

gastroesophageal reflux 16 ulcerative esophagitis 6 barrett's oesophagus 6 esophageal neoplasms 43 esophageal cancer 16 barretts syndrome 6 adenocarcinoma 43 cle 6

Diseases related to barrett's esophagus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1086)

id	Related Disease	Score	Top Affiliating Genes
1	gastric adenocarcinoma	35.4	PIK3CA, MYC, CLDN7, CLDN3, BCL2, BCL2L1
2	esophagus adenocarcinoma	35.2	BCL2, S100A8, CDKN1A, CDKN2A, MKI67, CCND1
3	clear cell adenocarcinoma	33.8	PIK3CA, SFRP1, VEGFA, CDH1, AMACR, ERBB2
4	lung adenocarcinoma	33.4	PIK3CA, VEGFA, BCL2, BCL2L1, MUC1, MUC3A
5	papillary adenocarcinoma	33.3	PCNA, MYC, MUC1, CEACAM5, CDH1, ERBB2
6	adenocarcinoma in situ	32.7	CEACAM5, CDKN1A, CDKN2A, CDX2, MCM2, IGF2BP3
7	endocervicitis	32.6	MYC, BCL2, MUC1, MUC5AC, MUC6, CEACAM5
8	breast adenocarcinoma	32.6	PCNA, VEGFA, BCL2, BAX, CDKN1A, MKI67
9	gastroesophageal reflux disease	32.1	BCL2, S100A8, CDX2, CDH1, IL6, IL8
10	small intestine adenocarcinoma	32.1	MUC1, MUC2, MUC5AC, BAX, CDX2, APC
11	ovarian clear cell adenocarcinoma	32.1	PIK3CA, VEGFA, CDH1, ERBB2, TP53, PTHLH
12	neuroendocrine carcinoma	31.7	MUC1, CEACAM5, CDX2, CDH1, FHIT, ENO2
13	cervical adenocarcinoma	31.6	PCNA, MYC, RARA, MUC5AC, CEACAM5, CDKN1A
14	ovarian mucinous adenocarcinoma	31.6	MUC2, MUC5AC, CDX2, AMACR, TP53, KRT7
15	signet ring cell adenocarcinoma	31.5	CLDN18, CDX2, KRT7, KRT20
16	ampulla of vater adenocarcinoma	31.4	MUC1, MUC2, MUC5AC, CDX2, KRT7, KRT20
17	bronchiolo-alveolar adenocarcinoma	31.1	MUC2, MUC3A, MUC5AC, MUC6, CEACAM5, CDX2
18	bladder adenocarcinoma	31.1	CDX2, KRT7, KRT20
19	tubular adenocarcinoma	31.0	MUC1, MUC2, MUC5AC, CEACAM5, CDX2, CDH1
20	barrett's adenocarcinoma	30.8	PCNA, VEGFA, MYC, MUC5AC, XRCC1, S100A2
21	atrophic gastritis	30.8	S100A8, CDX2, ODC1, TFF1, TFF2, SOD1
22	mutagen sensitivity	30.8	PCNA, XRCC1, GSTM1, GSTT1, IGFBP3, IGF1
23	nephrogenic adenoma	30.7	MUC1, AMACR, TP63, KRT7
24	colorectal cancer	30.6	MSH2, MLH1, GSTM1, GSTP1, GSTT1, APC
25	pancreatic ductal adenocarcinoma	30.6	VEGFA, MYC, BCL2, BCL2L1, MUC1, MUC2
26	squamous cell carcinoma	30.5	CD44, CDH1, MKI67, GSTP1, CCNA2, CCND1
27	hemochromatosis	30.4	BMP4, LCN2, GSTP1, IL6, IGF1, CALCA
28	adenosquamous carcinoma	30.4	MUC1, MUC2, MUC5AC, CEACAM5, FHIT, TP63
29	colon adenocarcinoma	30.1	VEGFA, MYC, BMP4, BCL2, BCL2L1, MUC1
30	gastritis	30.1	S100A8, CDX2, MLH1, MGMT, GSTT1, IL8
31	gallbladder adenocarcinoma	30.0	MYC, MUC1, MUC2, BAX, MAPK1, ERBB2
32	adenoid cystic carcinoma	30.0	PCNA, MUC1, CDH1, MKI67, CCND1, ERBB3
33	endometrial adenocarcinoma	30.0	PIK3CA, PCNA, VEGFA, MYC, CLDN3, BCL2
34	esophageal disease	29.9	S100A8, CEACAM5, MLH1
35	achalasia	29.9	PCNA, CDKN1A, IL10, IL2, IL23R, ENO2
36	dyspepsia	29.8	VEGFA, S100A8, IL8, CALCA, PTGS2, PTGS1
37	duodenal ulcer	29.7	MUC1, MUC6, S100A8, IL6, IL8, CAT
38	gastrointestinal stromal tumor	29.5	CDX2, APC, PTGS2, CTNNB1, WNT2
39	ethmoid sinus adenocarcinoma	29.5	PIK3CA, CCND1, EGFR
40	aggressive digital papillary adenocarcinoma	29.4	PCNA, MUC1, CDKN1A, CDH3, CD44, CDH1
41	bile duct mucinous adenocarcinoma	29.3	VEGFA, MUC1, MUC2, MUC5AC, CEACAM5, CDKN2A
42	crohn's disease	29.3	MUC2, MUC3A, LCN2, CDH3, IL10, IL12B
43	merkel cell carcinoma	29.2	MUC1, FHIT, ENO2, KRT8, KRT20, TOP2A
44	teratoma	29.2	PCNA, BCL2, MUC2, MUC5AC, BAX, CDKN2A
45	dermatomyositis	29.1	VEGFA, MUC1, S100A8, S100A9, MSH2, IL10
46	cystic teratoma	29.1	MUC2, MUC5AC, CDKN2A, CD1A, CDX2, TP53
47	malignant pleural mesothelioma	29.0	BCL2L1, MUC1, CEACAM5, CTNNA1, SOD2
48	liver cirrhosis	28.9	MUC5AC, ITGB1, MCM2, CCNA2, IGFBP3, CYP1A1
49	malignant mixed mullerian tumor	28.7	CDKN2A, CDH3, TP53, KRT7
50	periampullary adenocarcinoma	28.7	VEGFA, BAX, CCND1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 aluminum (as hydroxide), aluminum carbonate, aluminum carbonate basic, aluminum hydroxide, aluminum hydroxide gel, aluminum hydroxide gel,dried, aluminum/magnesium hydroxide, bethanechol, bethanechol chloride, calcium (as calcium carbonate), calcium (as carbonate), calcium carbonate, calcium carbonate pwdr [va product], calcium gluceptate, carboplatin, cimetidine, cimetidine hydrochloride, cisapride, cisplatin, cisplatin pwdr [va product], dihydroxyaluminum sodium carbonate, esomeprazole, esomeprazole magnesium, esomeprazole sodium, famotidine, isosorbide, isosorbide dinitrate, isosorbide mononitrate, lansoprazole, magaldrate, magnesium carbonate, magnesium carbonate blocks [va product], magnesium hydroxide, magnesium trisilicate, methotrexate, methotrexate sodium, metoclopramide, metoclopramide hydrochloride, milk of magnesia [va product], mitomycin, nizatidine, omeprazole, omeprazole magnesium, pantoprazole, pantoprazole sodium, profimer sodium, rabeprazole, sodium bicarbonate, sodium bicarbonate pwdr [va product], thiotepa

Genetic tests related to barrett's esophagus:

id	Genetic test	Affiliating Genes
1	Barrett's Esophagus clinical/research

MalaCards organs/tissues related to barrett's esophagus:

²²

MGI Mouse Phenotypes related to barrett's esophagus:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	SFRP4, PANX1, LGR5, IL12B, CALCA, TP63
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	REG1A, SFRP2, LGR5, CDH3, CDX2, CDX1
3	craniofacial phenotype	MP:0005382	10.1	BNC2, BMP4, KCNH2, LGR5, CDX1, IL12B
4	other phenotype	MP:0005395	9.8	RARA, MSR1, CDKN2A, ITGB1, IL2, PTGER2
5	hematopoietic system phenotype	MP:0005397	9.5	SFRP1, PCNA, BMP4, CLDN7, BCL2, BCL2L1
6	liver/biliary system phenotype	MP:0005370	9.1	VEGFA, BMP4, IL2, IL6, AMACR, TP53
7	embryogenesis phenotype	MP:0005380	8.7	PIK3CB, PIK3CA, SFRP1, SFRP2, BNC2, MYC
8	renal/urinary system phenotype	MP:0005367	8.6	SFRP4, BMP4, RARA, CLDN7, BCL2, BAX
9	no phenotypic analysis	MP:0003012	8.4	SFRP1, SFRP2, PCNA, VEGFA, MYC, BMP4
10	immune system phenotype	MP:0005387	8.3	RETNLB, SFRP1, RARA, PANX1, MUC2, MUC5AC
11	adipose tissue phenotype	MP:0005375	8.2	PIK3CA, SFRP1, MYC, BCL2, CDKN1A, IL6
12	pigmentation phenotype	MP:0001186	7.8	MYC, BCL2, CDKN2A, ITGB1, APC, MCM2
13	nervous system phenotype	MP:0003631	7.8	SFRP1, SFRP2, MYC, BMP4, RARA, PANX1
14	normal phenotype	MP:0002873	7.7	SFRP2, VEGFA, MYC, BMP4, RARA, XRCC1
15	mortality/aging	MP:0010768	7.6	PIK3CB, PIK3CA, RETNLB, SFRP1, SFRP2, SFRP4
16	hearing/vestibular/ear phenotype	MP:0005377	7.3	MYC, BMP4, RARA, PANX1, BCL2, BAX
17	digestive/alimentary phenotype	MP:0005381	7.2	RETNLB, SFRP4, VEGFA, BNC2, MYC, BMP4
18	integument phenotype	MP:0010771	7.2	MYC, CLDN7, BCL2, BCL2L1, MUC1, MSH2
19	limbs/digits/tail phenotype	MP:0005371	6.9	SFRP1, SFRP2, VEGFA, BMP4, RARA, BAX
20	reproductive system phenotype	MP:0005389	6.6	PIK3CA, REG1A, SFRP2, SFRP4, VEGFA, RARA
21	skeleton phenotype	MP:0005390	6.1	SFRP1, VEGFA, BNC2, MYC, BMP4, RARA
22	behavior/neurological phenotype	MP:0005386	5.8	PIK3CA, BMP4, PANX1, LGR5, XRCC1, CDKN1A
23	muscle phenotype	MP:0005369	5.7	PIK3CA, SFRP2, VEGFA, MYC, BMP4, RARA
24	growth/size phenotype	MP:0005378	5.0	PIK3CB, PIK3CA, SFRP1, SFRP2, SFRP4, BNC2
25	tumorigenesis	MP:0002006	4.9	PIK3CB, PIK3CA, MYC, RARA, BCL2, BCL2L1
26	vision/eye phenotype	MP:0005391	4.4	PIK3CA, VEGFA, BMP4, RARA, BCL2, MUC1
27	cardiovascular system phenotype	MP:0005385	4.4	PIK3CB, PIK3CA, SFRP1, SFRP2, SFRP4, VEGFA
28	homeostasis/metabolism phenotype	MP:0005376	2.3	PIK3CB, PIK3CA, REG1A, RETNLB, SFRP1, SFRP2
29	cellular phenotype	MP:0005384	2.1	PIK3CB, PIK3CA, SFRP2, PCNA, VEGFA, MYC

Articles related to barrett's esophagus:

(show top 50)    (show all 261)

id	Title	Authors	Year	Affiliating Genes
1	Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with Barrett esophagus and esophageal adenocarcinoma. (21791690)	Orloff M.... Eng C.	2011	MSR1, PANX1, CTHRC1
2	Expression, localization and polymorphisms of the nuc lear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma. (21977915)	Van de Winkel A.... Kuipers E.J.	2011	NR1I2
3	Lgr5, an intestinal stem cell marker, is abnormally e xpressed in Barrett's esophagus and esophageal adenocarcinoma. (19549212)	Becker L.... Mashimo H.	2010	LGR5
4	Elevated serum gastrin is associated with a history o f advanced neoplasia in Barrett's esophagus. (19904251)	Wang J.S.... Abrams J.A.	2010	GAST
5	Effects of Helicobacter pylori infection on genetic instability, the aberrant CpG island methylation status and the cellular phenotype in Barrett's esophagus in a Japanese population. (19048617)	Moriichi K.... Kohgo Y.	2009	CDH1, APC, CDKN2A
6	DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus. (19584833)	Wang J.S.... Canto M.I.	2009	APC, CDKN2A
7	Immunoreactivity of cytokeratins 7 and 20 in goblet c ells and columnar blue cells in patients with endoscopic evidence of Barrett's esophagus. (19578614)	Cantarelli J.C.... Kruel C.D.	2009	KRT7
8	Aneuploidy and overexpression of Ki67 and p53 as mark ers for neoplastic progression in Barrett's esophagus: a case-control study. (19638963)	Sikkema M.... Kuipers E.J.	2009	TP53, MKI67
9	Cytokeratin and CDX-2 expression in Barrett's esophagus. (18224560)	van Baal J.W.... Krishnadath K.K.	2008	CDX2
10	Hemochromatosis Gene Status as a Risk Factor for Barrett's Esophagus. (18470614)	Corley D.A.... Buffler P.	2008	HFE
11	Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus. (18559552)	Rygiel A.M.... Krishnadath K.K.	2008	EGFR, MYC
12	p16 mutation spectrum in the premalignant condition Barrett's esophagus. (19043591)	Paulson T.G.... Reid B.J.	2008	CDKN2A
13	Longitudinal study of insulin-like growth factor, insulin-like growth factor binding protein-3, and their polymorphisms: risk of neoplastic progression in Barrett's esophagus. (18006928)	Siahpush S.H.... Chen C.	2007	IGF1, IGFBP3
14	Bax upregulation may provide a rationale for the low incidence of esophageal adenocarcinoma in a Greek cohort of patients with Barrett's esophagus. (17591046)	Chatzopoulos D.... Venizelos I.	2007	BAX
15	Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus. (17875759)	Dvorak K.... Garewal H.	2007	STAT3, IL6
16	Predictors for squamous re-epithelialization of Barrett's esophagus after endoscopic biopsy. (17565646)	Amano Y.... Kinoshita Y.	2007	PTGS2, CDX2, MUC5AC
17	Downregulation of TNF-related apoptosis-inducing liga nd (TRAIL)/Apo2L in Barrett's esophagus with dysplasia and adenocarcinoma. (16785783)	Popnikolov N.K.... Pasricha P.J.	2006	TNFSF10
18	Expression of mucin-2 and correlation with PAS-alcian blue stain in Barrett's esophagus. (16995451)	Lopes C.V.... Hartmann A.	2006	MUC2
19	TP53 gene mutations are rare in nondysplastic Barrett's esophagus. (16416221)	Novotna K.... Sedlacek Z.	2006	TP53
20	hERG1 channels in human esophagus: evidence for their aberrant expression in the malignant progression of Barrett's esophagus. (16883575)	Lastraioli E.... Arcangeli A.	2006	KCNH2
21	Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas. (15967118)	Fox C.A.... Powell S.M.	2005	TFF1, CES2
22	Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. (15825175)	Zou H.... Ahlquist D.A.	2005	SFRP2, SFRP4
23	Defective mismatch-repair as a minor tumorigenic pathway in Barrett esophagus-associated adenocarcinoma. (15676154)	Falkenback D.... Nilbert M.	2005	MSH2, MLH1
24	Barrett's esophagus: a molecular perspective. (15913475)	Spechler S.J.	2005	TP53, CDKN2A, CDX2
25	Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. (15387324)	Konturek P.C.... MA1hldorfer S.	2004	GAPDH, PTGS2, GAST
26	Cytokeratin 7/20 and MUC1, 2, 5AC, and 6 expression patterns in Barrett's esophagus and intestinal metaplasia of the stomach: intestinal metaplasia of the cardia is related to Barrett's esophagus. (15354740)	Gulmann C.... Kay E.	2004	MUC1, KRT20
27	P53 protein and malignant progression in Barrett's metaplasia (Barrett's esophagus). (12809848)	Younes M.... Lechago J.	2003	TP53
28	Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach. (14508397)	Glickman J.N.... Odze R.D.	2003	MUC1, MUC2, MUC6
29	Enterocytic columnar non-goblet cells of Barrett's esophagus--an immunohistochemical demonstration of association with malignant evolution. (12866578)	Chaves P.... Soares J.	2003	SI
30	Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus. (12855631)	Sirieix P.S.... Fitzgerald R.C.	2003	MCM2
31	Immunohistological study of cell cycle-related factors, oncogene expression, and cell proliferation in adenocarcinoma developed in Barrett's esophagus. (12579284)	Fujii T.... Yamana H.	2003	TP53, PCNA, CDKN1A
32	Glutathione S-transferase-pi expression is downregulated in patients with Barrett's esophagus and esophageal adenocarcinoma. (12022988)	Brabender J.... Danenberg P.V.	2002	GSTP1
33	p53 expression in low grade dysplasia in Barrett's esophagus: correlation with interobserver agreement and disease progression. (12385431)	Skacel M.... Goldblum J.R.	2002	TP53
34	Cyclooxygenase-2 inhibitor therapy for the prevention of esophageal adenocarcinoma in Barrett's esophagus. (11904306)	Gupta R.A.... DuBois R.N.	2002	PTGS2
35	Barrett's esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. (12152167)	Warson C.... Dekker J.	2002	MUC2, TFF1, TFF2
36	Her-2/neu gene amplification, elevated mRNA expression, and protein overexpression in the metaplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus. (11406641)	Walch A.... Werner M.	2001	ERBB2
37	Molecular alterations of Barrett's esophagus on microdissected endoscopic biopsies. (11232646)	Romagnoli S.... Coggi G.	2001	TP53
38	Decreased expression of Fas (CD95/APO1) associated with goblet cell metaplasia in Barrett's esophagus. (10821489)	Younes M.... Younes A.	2000	FAS, FASLG
39	P53 mutational status improves estimation of prognosis in patients with curatively resected adenocarcinoma in Barrett's esophagus. (10955797)	Schneider P.M.... Siewert J.R.	2000	TP53
40	Analysis of Ki-67, p53 and Bcl-2 expression in the dysplasia-carcinoma sequence of Barrett's esophagus. (10373674)	Rioux-Leclercq N.... Ramee M.P.	1999	TP53, BCL2, MKI67
41	Beta 1 integrin expression in adenocarcinoma of Barrett's esophagus. (10370643)	Bottger T.C.... Junginger T.	1999	ITGB1
42	The molecular pathology of Barrett's esophagus. (10212817)	Werner M.... Hofler H.	1999	RAB11A, FHIT
43	Is Barrett's esophagus the precursor of most adenocarcinomas of the esophagus and cardia? A biochemical study. (9409571)	Mendes de Almeida J.C.... Altorki N.K.	1997	SI
44	Allelic loss of 9p21 and mutation of the CDKN2/p16 gene develop as early lesions during neoplastic progression in Barrett's esophagus. (8934532)	Barrett M.T.... Reid B.J.	1996	CDKN2A
45	E-cadherin expression in gastroesophageal reflux disease, Barrett's esophagus, and esophageal adenocarcinoma: an immunohistochemical and immunoblot study. (7572899)	Swami S.... Triadafilopoulos G.	1995	CDH1
46	Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma. (7906678)	Moore J.H.... Beer D.G.	1994	ANPEP, TP53
47	Increased expression of epidermal growth factor receptors in Barrett's esophagus associated with alkaline reflux: a putative model for carcinogenesis. (8438848)	Jankowski J.... Wormsley K.G.	1993	EGFR
48	Chemopreventive studies in Barrett's esophagus: a mod el premalignant lesion for esophageal adenocarcinoma. (1389696)	Garewal H.S.... Fennerty M.B.	1992	ODC1
49	Distinct immunohistochemical findings in columnar epithelium of esophageal inlet patch and of Barrett's esophagus. (2295298)	Feurle G.E.... Eckardt V.F.	1990	GAST
50	Epidermal growth factor receptor overexpression and trisomy 7 in a case of Barrett's esophagus. (2390926)	Garewal H.... Korc M.	1990	EGFR

Genes related to barrett's esophagus according to GeneCards:

(show top 50)    (show all 181)

id	Symbol	Description	Score	GeneCards Section Context
1	CTHRC1	collagen triple helix repeat containing 1	11.1	Summaries, Publications
2	ASCC1	activating signal cointegrator 1 complex subunit 1	11.1	Publications, Summaries
3	MUC3B	mucin 3B, cell surface associated	11.0	Publications
4	RETNLB	resistin like beta	11.0	Publications
5	GPX2	glutathione peroxidase 2 (gastrointestinal)	11.0	Publications
6	CDX2	caudal type homeobox 2	11.0	Publications
7	TFF2	trefoil factor 2	11.0	Publications
8	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Proteins, Publications, Expressions
9	MUC6	mucin 6, oligomeric mucus/gel-forming	11.0	Publications
10	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
11	KRT7	keratin 7	11.0	Publications
12	AMACR	alpha-methylacyl-CoA racemase	11.0	Publications
13	CD1A	CD1a molecule	11.0
14	KRT20	keratin 20	11.0	Publications
15	RAB11A	RAB11A, member RAS oncogene family	11.0	Publications
16	SI	sucrase-isomaltase (alpha-glucosidase)	11.0	Publications
17	TFF1	trefoil factor 1	11.0	Publications
18	TFF3	trefoil factor 3 (intestinal)	11.0
19	MCM2	minichromosome maintenance complex component 2	11.0	Publications
20	FGF1	fibroblast growth factor 1 (acidic)	11.0	Publications
21	ODC1	ornithine decarboxylase 1	11.0	Publications
22	TTF2	transcription termination factor, RNA polymerase II	11.0	Publications
23	GAST	gastrin	11.0	Publications
24	TP53	tumor protein p53	11.0	Publications
25	TERC	telomerase RNA component	11.0	Publications
26	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
27	PPIG	peptidylprolyl isomerase G (cyclophilin G)	11.0
28	GSTP1	glutathione S-transferase pi 1	11.0	Functions, Publications
29	S100A8	S100 calcium binding protein A8	11.0	Publications
30	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	11.0	Publications
31	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	11.0	Publications
32	BMP4	bone morphogenetic protein 4	11.0	Publications
33	CCND1	cyclin D1	11.0	Publications
34	SOD2	superoxide dismutase 2, mitochondrial	11.0	Publications
35	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
36	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
37	APC	adenomatous polyposis coli	11.0	Publications
38	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
39	TGFA	transforming growth factor, alpha	11.0	Publications
40	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
41	FHIT	fragile histidine triad	11.0	Publications
42	CLDN21	claudin 21	11.0	Publications
43	MIR205	microRNA 205	11.0	Publications
44	MIR143	microRNA 143	11.0	Publications
45	PGA5	pepsinogen 5, group I (pepsinogen A)	11.0	Publications
46	SPRR2D	small proline-rich protein 2D	11.0
47	HLA-S	major histocompatibility complex, class I, S (pseudogene)	11.0	Publications
48	PGA3	pepsinogen 3, group I (pepsinogen A)	11.0	Publications
49	PITX1	paired-like homeodomain 1	11.0	Publications
50	CDX1	caudal type homeobox 1	11.0	Publications

Pathways related to barrett's esophagus according to GeneDecks:

(show top 50)    (show all 293)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.8	ITGB1, PCNA
2	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.6	BCL2, ERBB3
3	Colorectal cancer20	10.6	MAP2K1, MSH2, PIK3CB
4	Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR141	10.4	MAP2K1, MAP2K2, PIK3CB, MAPK3
5	Non-small cell lung cancer20	10.0	PIK3CB, PIK3CA, CDKN2A, FHIT, MAP2K2, MAPK1
6	Breast Cancer Regulation by Stathmin136	9.8	ERBB3, ERBB2, PPP1R3A, EGFR, TGFA, MAP2K1
7	Development_EGFR signaling via small GTPases41	9.7	ERBB2, MAP2K1, MAPK1, MYC
8	Chronic myeloid leukemia20	9.7	MAP2K1, HDAC1, PIK3CB, CCND1, PIK3CA, MYC
9	Thyroid cancer20	9.7	PPARG, CTNNB1, TP53, CCND1, MAP2K1, MAPK1
10	Busulfan Pathway, Pharmacodynamics34	9.6	MGMT, GGT1, GSTP1, GSTM1, MLH1, MSH2
11	Development_Ligand-independent activation of ESR1 and ESR241	9.6	ERBB3, PIK3CA, PIK3CB, IGF1, TFF1, EGF
12	Development Ligand-independent activation of ESR1 and ESR210	9.5	CCND1, MAPK1, ERBB3, MAP2K1, PIK3CA, EGF
13	Development ERBB-family signaling10	9.5	MYC, MAPK3, ERBB2, MAP2K1, MAP2K2, EGF
14	Development_HGF signaling pathway41	9.4	MAPK1, MAPK3, MAP2K1, FAS, PIK3CB, CDH1
15	Development_ERBB-family signaling41	9.4	MAP2K1, ERBB2, EGF, EGFR, TGFA, MAPK3
16	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.3	MAP2K1, BAX, TP53, ERBB2, ERBB3, CASP3
17	Hepatitis C20	9.3	STAT3, EGFR, EGF, TP53, MAPK1, MAPK3
18	Akt Signaling36	9.1	IL2, IL12B, IL10, FGF1, BMP4, TIMP3
19	Endometrial cancer20	9.1	EGFR, PIK3CB, PIK3CA, MYC, EGF, CTNNB1
20	Melanoma20	9.1	MAP2K1, CCND1, IGF1, TP53, EGF, EGFR
21	Development IGF-RI signaling10	9.1	MAP2K1, PIK3CB, PIK3CA, IGF1, MYC, BCL2L1
22	Glioma20	9.1	IGF1, CCND1, TP53, EGF, EGFR, TGFA
23	Development_IGF-1 receptor signaling41	9.0	BCL2L1, IGF2, MAPK3, PIK3CB, IGF1, IGFBP3
24	Glioblastoma Multiforme36	8.9	CDKN1A, MGMT, APC, MAP2K2, MAPK3, MAPK1
25	ILK Signaling36	8.9	FGF1, CDH1, ITGB1, MAPK3, MAPK1, IGF2
26	Development EGFR signaling via small GTPases10	8.8	MAPK1, PIK3CB, PIK3CA, MYC, MAP2K2, EGFR
27	Prostate cancer20	8.7	IGF1, ERBB2, TP53, CTNNB1, EGF, EGFR
28	Development Prolactin receptor signaling10	8.7	MAPK3, PIK3CB, PIK3CA, MYC, BCL2, BCL2L1
29	Development_Prolactin receptor signaling41	8.6	STAT3, SRC, MAP2K1, MAPK1, MAPK3, MAP2K2
30	Nanog in Mammalian ESC Pluripotency36	8.6	MAP2K2, ERBB3, IGF1, IGF2, MAP2K1, EGF
31	Bladder cancer20	8.5	CDKN1A, CDKN2A, CDH1, IL8, MAP2K2, MAPK3
32	Development_EGFR signaling pathway41	8.3	EGFR, EGF, SRC, ERBB2, MAP2K1, MAPK3
33	Cellular Apoptosis Pathway36	8.3	BMP4, BCL2, BCL2L1, BAX, CDKN2A, FGF1
34	Mitochondrial Apoptosis36	8.2	IGF1, IGF2, CASP3, TP53, EGF, TIMP3
35	PEDF Induced Signaling36	8.2	BCL2L1, SOD2, TNFSF10, BCL2, BMP4, IL10
36	ErbB signaling pathway20	8.2	SRC, MAPK3, PIK3CB, TGFA, EGFR, EGF
37	EGF Pathway36	8.2	CDH1, ERBB2, CTNNB1, SRC, EGF, EGFR
38	Rho Family GTPases36	7.9	FGF1, BAX, CDH3, CDH1, ITGB1, MAP2K1
39	Signal transduction PTEN pathway10	7.8	MAPK1, MAPK3, MAP2K2, ITGB1, CDKN1A, PCNA
40	Molecular Mechanisms of Cancer36	7.5	BAX, CDKN1A, CDKN2A, CDH1, ITGB1, FGF1
41	TGF-Beta Pathway36	7.4	IL12B, IL8, MAP2K2, IL2, IL10, FGF1
42	Pancreatic Adenocarcinoma36	7.4	EGFR, STAT3, TGFA, TIMP3, BMP4, MAP2K2
43	Colorectal Cancer Metastasis36	7.4	IL6, APC, MAP2K2, MAPK3, MAPK1, MAP2K1
44	Tec Kinases Signaling36	7.3	ERBB3, STAT3, IGF2, IL6, IGF1, IL8
45	Endothelin-1 Signaling Pathway36	7.3	CASP3, ERBB3, ERBB2, IL2, TNFSF10, SRC
46	STAT3 Pathway36	7.2	BMP4, TNFSF10, SRC, STAT3, MAP2K1, MYC
47	JAK-STAT Pathway36	7.0	ERBB3, IGF2, TGFA, TIMP3, EGFR, EGF
48	ERK Signaling36	7.0	MYC, BMP4, ITGB1, IL10, IL12B, IL2
49	MAPK Family Pathway36	7.0	IL6, IL2, IL12B, IL10, FGF1, BAX
50	Pathways in cancer20	6.8	HDAC1, STAT3, TGFA, EGFR, EGF, NOS2

Compounds related to barrett's esophagus according to GeneDecks:

(show top 50)    (show all 471)

id	Compound	Score	Top Affiliating Genes
1	h2o232	10.8	PIK3CB, S100A9, MAP2K1, CCNB1, GPX2, ODC1
2	hematoxylin32	10.8	PCNA, MUC1, MUC2, MUC5AC, CEACAM5, CDKN2A
3	crcs32	10.6	PIK3CA, MUC1, MUC2, S100A8, CEACAM5, MSH2
4	vincristine32 34 9 9	13.5	MGMT, MAPK3, CALCA, PTHLH, ODC1, ABCC3
5	pge232	9.8	BMP4, MUC5AC, CDH1, FGF1, APC, FASLG
6	folate32	9.7	MYC, RARA, MUC1, XRCC1, CDKN2A, CDH1
7	sulindac32 9 9	11.7	PCNA, BCL2, BCL2L1, BAX, CDKN1A, CDH1
8	formaldehyde32 18	10.7	PCNA, MUC1, CD44, CDH1, MKI67, MGMT
9	olomoucine32 42 9 9	12.4	PCNA, BCL2, BAX, CDKN1A, CDKN2A, MAPK3
10	12-o-tetradecanoylphorbol 13-acetate32	9.3	MYC, RARA, MUC2, MSR1, CDKN1A, CD44
11	arginine32	9.2	PIK3CA, RARA, KCNH2, XRCC1, CD44, MLH1
12	sulindac sulfide32	9.2	PCNA, BCL2, BCL2L1, BAX, CCND1, CASP3
13	dutp32	9.1	PCNA, BCL2, BCL2L1, BAX, MKI67, FHIT
14	agar32	8.9	PIK3CA, RARA, MUC1, CEACAM5, CDKN2A, CDH1
15	vitamin a32 9 18 9	11.7	MYC, RARA, LCN2, MLH1, GSTM1, FAS
16	n-(4-hydroxyphenyl)retinamide32	8.6	MYC, RARA, BCL2, BCL2L1, BAX, CDKN1A
17	depsipeptide32	8.6	MYC, BCL2, BCL2L1, BAX, CDKN1A, CDKN2A
18	heparin32 9 18 9	11.6	PIK3CA, SFRP1, BMP4, CDH1, CD55, ITGB1
19	progesterone32 42 9 18 9	12.4	PIK3CA, SFRP4, PCNA, BMP4, RARA, BCL2
20	oxaliplatin32 34 9 9	11.4	VEGFA, BCL2L1, XRCC1, CEACAM5, CDKN1A, MLH1
21	cholesterol32 9 18 9	11.2	PIK3CB, PIK3CA, CLDN3, MUC1, MUC2, MUC5AC
22	adenylate32	8.2	PIK3CA, BMP4, KCNH2, CD44, CDH1, GSTP1
23	rapamycin32 42	9.2	VEGFA, BMP4, IL2, FASN, CCNB1, CCNA2
24	glutamate32	8.2	PIK3CB, PIK3CA, PCNA, S100A8, MSH2, CDH1
25	agarose32	8.2	MYC, BCL2, BCL2L1, MUC1, MUC2, BAX
26	etoposide32 42 9 9	11.2	PIK3CB, PIK3CA, PCNA, MYC, RARA, BCL2
27	erlotinib32 34 9 9	11.0	PIK3CA, VEGFA, CDH1, MAPK1, CCND1, IGF1
28	celecoxib32 42 34 9 18 9	12.8	PCNA, VEGFA, BCL2, BAX, CDKN1A, CDH1
29	flavopiridol32 9 9	9.8	VEGFA, BCL2, BCL2L1, BAX, CDKN1A, CDKN2A
30	alanine32	7.8	PCNA, MYC, RARA, KCNH2, S100A8, MSH2
31	vitamin d32	7.7	RARA, CDKN1A, CDX2, CD44, CDH1, GSTM1
32	cyclosporin a32 42	8.7	PIK3CA, MYC, BMP4, CD44, CD55, ITGB1
33	gefitinib32 34 9 9	10.7	PIK3CA, VEGFA, BCL2L1, CEACAM5, CDKN1A, CDH1
34	cysteine32	7.6	RETNLB, PCNA, BMP4, RARA, BCL2L1, MUC1
35	lactate32	7.4	PIK3CA, PCNA, CEACAM5, CD44, CDH1, MKI67
36	docetaxel32 34 9 9	10.4	VEGFA, MYC, BCL2, BCL2L1, BAX, CDKN1A
37	15-deoxy-delta-12,14-prostaglandin j232	7.4	VEGFA, MYC, BCL2L1, CDKN1A, IL10, IL6
38	ag 147832	7.3	PIK3CA, MUC5AC, IL8, FASLG, FAS, MAPK3
39	sb 20358032 42	8.1	VEGFA, BMP4, BCL2, BCL2L1, CDKN1A, CDH1
40	herbimycin a32 42	8.1	MYC, CDH1, ITGB1, IL2, IL6, IL8
41	ly29400232	6.6	PIK3CB, PIK3CA, VEGFA, RARA, MUC2, CD44
42	vegf32	6.6	PIK3CB, PIK3CA, PCNA, MYC, BMP4, CLDN3
43	indomethacin32 9 9	8.4	PCNA, MYC, CDH1, IL2, IL6, APC
44	doxorubicin32 34 9 9	9.2	PIK3CA, BCL2L1, CEACAM5, MSH2, CD44, CDH1
45	5fluorouracil32	5.9	PIK3CA, PCNA, VEGFA, BCL2, BCL2L1, MUC1
46	testosterone32 9 18 9	8.6	PIK3CA, SFRP1, PCNA, RARA, KCNH2, MUC1
47	paclitaxel32 34 9 9	8.4	PIK3CA, PCNA, VEGFA, MYC, RARA, BCL2
48	actinomycin d32	4.9	PIK3CA, VEGFA, MYC, BMP4, RARA, BCL2
49	cisplatin32 34 9 9	7.1	PIK3CA, PCNA, VEGFA, MYC, BCL2, BCL2L1
50	dexamethasone32 42 34 9 9	7.7	PIK3CA, PCNA, VEGFA, MYC, BMP4, RARA

Cellular components related to barrett's esophagus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:005796	10.6	MUC5B, MUC5AC, MUC3B, MUC3A, MUC2, MUC1
2	tight junction	GO:005923	10.5	EPCAM, CXADR, APC, CLDN3, CLDN18, CLDN7
3	lateral plasma membrane	GO:016328	10.4	EPCAM, CTNNB1, ERBB3, APC, CDH1, CLDN7
4	basolateral plasma membrane	GO:016323	9.5	EPCAM, SLC22A5, CXADR, TGFA, EGFR, ERBB2
5	nucleoplasm	GO:005654	8.6	NR1H4, PPIG, PPARG, TP63, TP53, ERCC2
6	extracellular region	GO:005576	7.1	SPARC, PTHLH, TMEFF2, TNFSF10, AKR1B10, CALCA
7	extracellular space	GO:005615	7.0	PGC, ERBB3, TNFSF10, PTHLH, SPARC, CTSD
8	cytoplasm	GO:005737	6.7	CTHRC1, CTNNB1, PPIG, SMTN, NQO1, NOS2
9	cytosol	GO:005829	5.5	SRC, TP53, CAT, CASP3, IGF2BP3, CCND1
10	nucleus	GO:005634	5.4	SRC, SPARC, CTNNB1, PPARG, PPIG, NOS2

Biological processes related to barrett's esophagus according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	digestion	GO:007586	11.2	PGC, PGA5, TFF3, TFF2, TFF1, AKR1C2
2	somatic stem cell maintenance	GO:035019	10.9	SOX2, SKI, APC, CDX2, CDKN2A, SFRP1
3	O-glycan processing	GO:016266	10.9	MUC6, MUC5B, MUC5AC, MUC3B, MUC3A, MUC2
4	activation of MAPKK activity	GO:000186	10.8	MAP2K2, BMP4
5	response to organic cyclic compound	GO:014070	10.7	STAT3, TIMP3, CTNNA1, PTGS2, CCND1, ENO2
6	negative regulation of fibroblast proliferation	GO:048147	10.7	SKI, TP53, GSTP1, BAX, MYC, SFRP1
7	negative regulation of epithelial cell proliferation	GO:050680	10.7	RUNX3, SOX2, KRT4, BMP4, SFRP2, SFRP1
8	calcium-independent cell-cell adhesion	GO:016338	10.6	CLDN3, CLDN18, CLDN7, CLDN5, CLDN2
9	response to estradiol stimulus	GO:032355	10.6	STAT3, TFF1, CTNNB1, PTGS2, ENO2, RARA
10	xenobiotic metabolic process	GO:006805	10.6	GGT1, NQO1, NR1I2, CYP27B1, CYP1A1, PTGS1
11	response to ethanol	GO:045471	10.4	SPARC, CCND1, MGMT, S100A9, S100A8, BCL2
12	response to lipopolysaccharide	GO:032496	10.3	NR1H4, SPARC, CYP27B1, PTGER1, PTGS2, PTGER2
13	regulation of stress-activated MAPK cascade	GO:032872	10.3	MAP2K1, MAPK1, MAPK3, MAP2K2, GSTP1
14	aging	GO:007568	10.2	SI, TIMP3, TOP2A, CTNNA1, PTGS1, ERCC2
15	regulation of early endosome to late endosome transport	GO:2000641	10.2	MAP2K1, MAPK1, MAPK3, MAP2K2
16	regulation of Golgi inheritance	GO:090170	10.2	MAP2K1, MAPK1, MAPK3, MAP2K2
17	regulation of cell proliferation	GO:042127	10.1	DNMT1, NOS2, SPARC, PTGS1, PTGER2, ERBB3
18	cell cycle arrest	GO:007050	10.1	SOX2, SKIL, TP53, MAP2K1, APC, IL8
19	response to growth factor stimulus	GO:070848	10.1	SOX2, SKIL, FAS, FASLG, MYC
20	cell proliferation	GO:008283	10.1	ERBB2, ERCC2, GNL3, MAP2K1, MKI67, BCL2L1
21	negative regulation of neuron apoptotic process	GO:043524	10.0	SOD2, SOD1, TGFA, ERBB3, MSH2, BAX
22	positive regulation of epithelial cell proliferation	GO:050679	10.0	TGFA, EGFR, ERBB2, IGF1, FGF1, BMP4
23	release of cytochrome c from mitochondria	GO:001836	9.9	SOD2, TP53, CASP3, BAX, BCL2L1, BCL2
24	response to estrogen stimulus	GO:043627	9.9	TIMP3, PPARG, CTNNA1, CYP27B1, CCND1, FAS
25	ovarian follicle development	GO:001541	9.9	BMP4, BCL2, BCL2L1, BAX, CTNNA1, SOD1
26	apoptotic DNA fragmentation	GO:006309	9.9	SOD1, CASP3, CDKN2A, BAX, MYC, SFRP1
27	positive regulation of activated T cell proliferation	GO:042104	9.9	IGF1, IGF2, IL23R, IL2, IL12B
28	response to toxin	GO:009636	9.8	NQO1, BCL2, BAX, CDKN1A, CDH1, MGMT
29	induction of apoptosis by intracellular signals	GO:008629	9.7	TP53, CASP3, CDKN1A, BAX, BCL2L1, BCL2
30	positive regulation of apoptotic process	GO:043065	9.7	IGFBP3, TP53, TNFSF10, PTGS2, CTNNB1, TOP2A
31	response to DNA damage stimulus	GO:006974	9.7	CCND1, CASP3, TP53, TOP2A, MAPK3, APC
32	activation of pro-apoptotic gene products	GO:008633	9.6	TNFSF10, FAS, FASLG, BAX, BCL2, MYC
33	negative regulation of cell proliferation	GO:008285	9.6	IGFBP3, IGF1, TP53, PTGS2, PTHLH, CYP27B1
34	neuron apoptotic process	GO:051402	9.5	GAPDH, TP63, TP53, ERBB3, CASP3, FAS
35	response to glucocorticoid stimulus	GO:051384	9.5	SI, SPARC, PTGS2, MAP2K1, FAS, IL6
36	MAPK cascade	GO:000165	9.4	TGFA, EGFR, MAP2K1, MAPK1, MAPK3, MAP2K2
37	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	CD44, ITGB1, IL6, IGF2, IGF1, TP53
38	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.0	IL6, CD44, BCL2, VEGFA, SFRP2, PIK3CA
39	induction of apoptosis	GO:006917	9.0	RUNX3, NOX5, PPARG, TNFSF10, TP63, ERCC2
40	Ras protein signal transduction	GO:007265	9.0	CCNA2, IGF1, TP53, SRC, MAP2K1, MAPK1
41	virus-host interaction	GO:019048	8.6	HDAC1, CXADR, STAT3, KRT7, KRT8, SRC
42	epidermal growth factor receptor signaling pathway	GO:007173	8.6	TGFA, EGFR, EGF, SRC, ERBB2, MAP2K1
43	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.5	TP53, TP63, CTNNB1, PPARG, NR1H4, SKI
44	anti-apoptosis	GO:006916	8.5	FAS, IGF1, TGFA, SOD1, HDAC1, IL2
45	response to drug	GO:042493	8.4	SFRP1, ENO2, CCND1, ERBB3, PTGS2, CTNNB1
46	positive regulation of transcription, DNA-dependent	GO:045893	8.3	TP53, TP63, CTNNB1, PPARG, NR1I2, EGF
47	negative regulation of apoptotic process	GO:043066	8.2	CASP3, CAT, ERCC2, TP53, CTNNA1, EGFR
48	positive regulation of cell proliferation	GO:008284	8.0	ODC1, PTHLH, AKR1C2, IGF1, EGF, EGFR
49	platelet activation	GO:030168	7.6	SOD1, EGF, SPARC, SRC, IGF1, MAPK1
50	signal transduction	GO:007165	6.9	TNFSF10, SRC, SPARC, PPARG, NR1H4, NR1I2

Molecular functions related to barrett's esophagus according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	10.6	KRT10, KRT7, KRT4, KRT8, CTNNA1, CLDN3
2	BH3 domain binding	GO:051434	10.1	BCL2, BCL2L1, BAX
3	protein kinase binding	GO:019901	10.0	CCND1, TP53, SKI, STAT3, CCNA2, CCNB1
4	identical protein binding	GO:042802	9.4	IL12B, FAS, ERBB2, TP53, TP63, EGFR
5	enzyme binding	GO:019899	8.9	HDAC1, TOP2A, EGFR, PPARG, CTNNB1, PTGS2
6	protein heterodimerization activity	GO:046982	8.6	ENO2, ERBB3, ERBB2, TP53, EGFR, TOP2A
7	growth factor activity	GO:008083	8.3	IGF2, IGF1, EGF, TGFA, TFF1, DKK1
8	cytokine activity	GO:005125	8.3	WNT2, TNFSF10, FASLG, IL6, IL2, IL12B
9	protein binding	GO:005515	2.5	IGF1, CTNNA1, CTNNB1, PPARG, NR1H4, NR1I2