CLE
MCID: BRR003
MIFTS: 68

Barrett's Esophagus (CLE) malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Barrett's Esophagus

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Barrett syndrome, also known as barrett esophagus, is a disorder in which the lining of the esophagus (the tube that carries food from the throat to the stomach) is replaced by tissue that is similar to the lining of the intestine. this process is called intestinal metaplasia. the exact cause of barrett syndrome is not known, but gastroesophageal reflux disease (gerd) is a risk factor for the condition. while barrett syndrome itself does not cause symptoms, the acid reflux associated with gerd often leads to symptoms of heartburn.  less than 1% of people with barrett syndrome develop a rare type of cancer called esophageal adenocarcinoma. treatment of gerd should improve symptoms, and may keep barrett syndrome from getting worse. endoscopic or surgical treatments can be used to treat barrett syndrome with severe dysplasia or cancer. last updated: 3/5/2010

MalaCards: Barrett's Esophagus, also known as barrett esophagus, is related to adenocarcinoma and gastric ulcer. An important gene associated with Barrett's Esophagus is CTHRC1 (collagen triple helix repeat containing 1), and among its related pathways is O-linked glycosylation of mucins. The drugs aluminum hydroxide and aluminum hydroxide gel and the compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, bone and liver, and related mouse phenotypes are digestive/alimentary and homeostasis/metabolism.

Wikipedia:63 Barrett esophagus (British English: Barrett\'s oesophagus), sometimes called Barrett syndrome or... more...

Aliases & Classifications for Barrett's Esophagus

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8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

barrett's esophagus 8
barrett esophagus 8 42 20 22 44 60
barrett's ulcer of esophagus 8 60
chronic peptic ulcer and esophagitis syndrome 42
barrett's esophagus with esophagitis 8
gastroesophageal reflux disease 60
peptic ulcer of esophagus 60
esophagitis-peptic ulcer 42
columnar-like esophagus 42
ulcerative esophagitis 8
barrett's oesophagus 8
esophageal carcinoma 60
barretts esophagus 10
barretts syndrome 8
barrett syndrome 42
barrett ulcer 42
cle 8


External Ids:

Disease Ontology8 DOID:9206
MeSH34 D001471
ICD9CM27 530.85
NCIt39 C2891
ICD1025 K22.7

Related Diseases for Barrett's Esophagus

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17GeneCards, 18GeneDecks
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Diseases related to Barrett's Esophagus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1MUC2, MUC6, MUC5AC, MUC3B, CDKN2A, CDX2
2gastric ulcer30.5GAST, TFF1, TFF2, TFF3, MUC5AC
3duodenitis30.5GAST
4duodenal ulcer30.4MUC6, TFF1, GAST
5esophagitis30.3CDX2, GAST
6squamous cell carcinoma30.2AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
7cystic fibrosis30.2AMACR, MUC2, MUC6, MUC5AC, MUC3B, SI
8otitis media30.2MUC5AC
9gastric adenocarcinoma30.1GAST, TFF1, MUC2, CDX2, KRT7, KRT20
10tubular adenocarcinoma30.1MUC2, MUC5AC, CDX2, KRT7, KRT20
11bile reflux30.1TFF1
12gastritis29.9TERC, CDX2, GAST
13peptic ulcer29.9MUC5AC, GAST
14hepatocellular carcinoma29.9AMACR, TFF3, MKI67, MUC2, MUC5AC, CDKN2A
15lung cancer29.9AMACR, TFF1, MUC2, MUC5AC, CDKN2A, CDX2
16lung adenocarcinoma29.9AMACR, MUC5AC, CDKN2A, CDX2, KRT7, KRT20
17transitional cell carcinoma29.8MKI67, KRT7, KRT20, TERC
18papilloma29.8MUC2, MUC5AC
19hepatitis29.8AMACR
20hypercalcemia29.8GAST
21esophagus adenocarcinoma10.8
22eosinophilic esophagitis10.7
23dyspepsia10.7
24laryngeal disease10.6
25laryngitis10.6
26asthma10.6
27irritable bowel syndrome10.5
28morbid obesity10.5
29hiatus hernia10.5
30barrett's adenocarcinoma10.5
31tooth disease10.5
32barrett esophagus/esophageal adenocarcinoma10.5
33diabetes mellitus10.4
34tooth erosion10.4
35esophageal cancer10.4
36bruxism10.4
37diabetic neuropathy10.4
38duodenal disease10.4
39movement disease10.4
40neuropathy10.4
41esophageal atresia10.3
42peptic esophagitis10.3
43bronchiolitis obliterans10.3
44bronchiolitis10.3
45coats disease10.3
46diabetic autonomic neuropathy10.3
47arthritis10.3
48autonomic neuropathy10.3
49rheumatoid arthritis10.3
50tongue disease10.3

Graphical network of the top 20 diseases related to Barrett's Esophagus:



Diseases related to barrett's esophagus

Clinical Features for Barrett's Esophagus

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Genetic Tests for Barrett's Esophagus

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20GeneTests, 22GTR
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Genetic tests related to Barrett's Esophagus:

id Genetic test Affiliating Genes
1 Barrett Esophagus20
2 Barrett's Esophagus22

Anatomical Context for Barrett's Esophagus

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32MalaCards
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MalaCards organs/tissues related to Barrett's Esophagus:

32
Lymph node, Bone, Liver, Testes

Animal Models for Barrett's Esophagus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Barrett's Esophagus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538111.2TERC, GAST, TFF1, TFF2, TFF3, MUC2
2MP:000537611.2TFF2, GAST, CTHRC1, AMACR, TFF3, MUC2
3MP:000537910.9TFF2, MUC2, CDKN2A, CDX2, GPX2, TERC
4MP:000200610.8GAST, TFF1, MUC2, CDKN2A, CDX2, TERC
5MP:000538710.7GAST, TFF2, TFF3, MUC2, MUC5AC, CDKN2A

Publications for Barrett's Esophagus

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50PubMed
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Articles related to Barrett's Esophagus:

(show top 50)    (show all 821)
idTitleAuthorsYear
1
Acetic acid compared with i-scan imaging for detecting Barrett's esophagus: a randomized, comparative trial. (23953402)
2014
2
In vivo endomicroscopy improves detection of Barrett's esophagus-related neoplasia: a multicenter international randomized controlled trial (with video). (24219822)
2014
3
Single Nucleotide Polymorphisms of Caudal Type Homeobox 1 and 2 Are Associated with Barrett's Esophagus. (23918153)
2014
4
Cost-effectiveness of endoscopic surveillance of non-dysplastic Barrett's esophagus. (24079411)
2014
5
Endotherapy versus surgery for early neoplasia in Barrett's esophagus: a meta-analysis. (24079410)
2014
6
Barrett's esophagus is frequently overdiagnosed in clinical practice: results of the Barrett's Esophagus Endoscopic Revision (BEER) study. (24262638)
2013
7
Radiofrequency ablation in the management of Barrett's esophagus - preliminary own experience. (23837094)
2013
8
Long-term outcomes of patients with Barrett's esophagus and high-grade dysplasia or early cancer treated with endoluminal therapies with intention to complete eradication. (23317687)
2013
9
Histopathological diagnosis of adenocarcinoma in Barrett's esophagus. (23981237)
2013
10
Barrett's esophagus in 2012: updates in pathogenesis, treatment, and surveillance. (23605564)
2013
11
Can You Stop Surveillance After Radiofrequency Ablation of Barrett's Esophagus? A Glass Half Full. (23727498)
2013
12
MicroRNA expression signatures during malignant progression from Barrett's esophagus to esophageal adenocarcinoma. (23466817)
2013
13
Dietary intake of vegetables, folate, and antioxidants and the risk of Barrett's esophagus. (23420329)
2013
14
Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation. (23939625)
2013
15
Endomicroscopy in Barrett's esophagus. (23735103)
2013
16
Which is the optimal treatment for Barrett's esophagus with high grade dysplasia--ablation or complete endoscopic removal? (22271034)
2012
17
Dysplasia detection rate of confirmatory EGD in nondysplastic Barrett's esophagus. (23020509)
2012
18
Barrett's esophagus and I^-carotene therapy: symptomatic improvement in GERD and enhanced HSP70 expression in esophageal mucosa. (23464395)
2012
19
Molecular biomarkers and ablative therapies for Barrett's esophagus. (23061708)
2012
20
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis. (21951971)
2012
21
An analysis of esophagectomy and other techniques in the management of high-grade dysplasia of Barrett's esophagus. (21518102)
2012
22
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma. (22954106)
2012
23
Screening and surveillance for Barrett's esophagus: current issues and future directions. (22508325)
2012
24
Management of low-grade dysplasia in Barrett's esophagus. (22508323)
2012
25
Endoscopic TriModal imaging and biomarkers for neoplasia conjoined: a feasibility study in Barrett's esophagus. (23067399)
2012
26
miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus. (21448356)
2011
27
Predictors for neoplastic progression in patients with Barrett's Esophagus: a prospective cohort study. (21577245)
2011
28
Smoking and Barrett's esophagus in women who undergo upper endoscopy. (21448698)
2011
29
Biology of Barrett's esophagus and esophageal adenocarcinoma. (21112495)
2011
30
Familial Barrett's esophagus: clues to genetic risks for esophageal adenocarcinoma. (21461914)
2011
31
Field cancerization in Barrett's esophagus. (22127108)
2011
32
Barrett's esophagus: prevalence-incidence and etiology-origins. (21950804)
2011
33
Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. (19549212)
2010
34
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma. (20128019)
2010
35
Large intra- and inter-individual variability of genes expression levels limits potential predictive value of molecular diagnosis of dysplasia in Barrett's esophagus. (17952395)
2008
36
Gains and amplifications of c-myc, EGFR, and 20.q13 loci in the no dysplasia-dysplasia-adenocarcinoma sequence of Barrett's esophagus. (18559552)
2008
37
Usefulness of magnifying endoscopy with narrow band imaging for the detection of specialized intestinal metaplasia in columnar-lined esophagus and Barrett's adenocarcinoma. (17185078)
2007
38
Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. (17405999)
2007
39
TP53 gene mutations are rare in nondysplastic Barrett's esophagus. (16416221)
2006
40
p53 protein overexpression and p53 mutation analysis in patients with intestinal metaplasia of the cardia and Barrett's esophagus. (15183537)
2004
41
Cardiac mucosa in the remnant esophagus after esophagectomy is an acquired epithelium with Barrett's-like features. (15349112)
2004
42
Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach. (14508397)
2003
43
High-grade dysplasia and superficial adenocarcinoma in Barrett's esophagus: histological mapping and expression of p53, p21 and Bcl-2 oncoproteins. (12536310)
2003
44
Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation. (9422531)
1998
45
Flow cytometric DNA analysis and p53 protein expression show a good correlation with histologic findings in patients with Barrett's esophagus. (9708926)
1998
46
Adenocarcinoma in situ in Barrett's esophagus with stricture of 10-yr duration: a cytological diagnosis. (8759681)
1996
47
Increased expression of the cyclin D1 gene in Barrett's esophagus. (8781742)
1996
48
17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy. (8162566)
1994
49
Chemopreventive studies in Barrett's esophagus: a model premalignant lesion for esophageal adenocarcinoma. (1389696)
1992
50
Epidermal growth factor receptor expression in Barrett's esophagus. (1444753)
1992

Genetic Variations for Barrett's Esophagus

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Expression for genes affiliated with Barrett's Esophagus

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Barrett's Esophagus

Search GEO for disease gene expression data for Barrett's Esophagus.

Pathways for genes affiliated with Barrett's Esophagus

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53Reactome
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Pathways related to Barrett's Esophagus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7MUC3B, MUC5AC, MUC6, MUC2

Compounds for genes affiliated with Barrett's Esophagus

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Barrett's Esophagus according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1paraffin4411.7AMACR, TFF1, TFF3, MKI67, MUC2, MUC6
2progesterone44 59 28 11 2415.6MUC2, MKI67, TFF3, TFF1, AMACR, MUC6
3tyrosine4411.5AMACR, GAST, TFF3, MKI67, MUC5AC, MUC3B
4retinoic acid44 2412.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
5cysteine4411.4AMACR, TFF1, TFF3, MUC2, MUC5AC, CDKN2A
6calcium44 49 11 2414.4AMACR, GAST, TFF1, TFF2, MKI67, MUC2
7hematoxylin4411.4AMACR, TFF1, MKI67, MUC2, MUC5AC, CDKN2A
8testosterone44 59 11 2414.4AMACR, GAST, TFF1, MKI67, MUC5AC, CDKN2A
9oligonucleotide4411.4AMACR, MUC2, MUC6, MUC5AC, MUC3B, CDKN2A
10glucose4411.4AMACR, GAST, TFF1, MUC2, MUC5AC, CDKN2A
11methotrexate44 49 1113.3TFF3, MKI67, MUC2, MUC5AC, CDKN2A, SI
125fluorouracil4411.2MKI67, MUC2, MUC6, MUC5AC, CDKN2A, TERC
13vegf4411.2GAST, TFF1, TFF3, MKI67, CDKN2A, KRT7
14dexamethasone44 49 28 1114.2AMACR, TFF1, MUC2, MUC5AC, CDKN2A, SI
15thymidine44 2412.2GAST, TFF1, MKI67, CDX2, SI, TERC
16fatty acid4411.1AMACR, TFF1, CDKN2A, CDX2, SI
17cholesterol44 28 11 2414.1AMACR, MUC2, MUC6, MUC5AC, CDKN2A, SI
18lipid4411.1AMACR, MKI67, CDKN2A, GPX2, SI, KRT7
19steroid4411.1TFF1, TFF3, MKI67, MUC5AC, CDKN2A, CDX2
20streptavidin4411.1AMACR, MKI67, KRT7, KRT20
21carbohydrates4411.1MKI67, MUC2, MUC5AC, SI
22ethanol44 49 11 2414.1TFF1, TFF3, MKI67, MUC5AC, SI
23cesium chloride44 5912.0MUC5AC, MUC2, TFF1
24butyrate4411.0SI, CDX2
255-aza-2deoxycytidine4411.0MUC2, CDKN2A, CDX2, KRT7
26deoxycholic acid44 28 11 2414.0SI, CDX2, MUC2
27estrogen4411.0SI
28methanol44 2411.9KRT7, CDKN2A, MKI67
29tamoxifen44 49 28 1113.9TFF1, TFF3, MKI67, TERC
30h2o24410.9TFF1, TFF3, CDKN2A, GPX2, SI
31polysaccharide4410.8KRT7, SI, MUC5AC, MUC6
32triiodothyronine4410.8SI, MUC5AC, GAST
33actinomycin d4410.7CDKN2A, MUC2, TFF3, TFF1
34biotin44 11 2412.7AMACR, MKI67, CDKN2A
35doxorubicin44 49 1112.6TERC, KRT20, CDKN2A, MKI67
36mucicarmine4410.3KRT7, KRT20

GO Terms for genes affiliated with Barrett's Esophagus

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16Gene Ontology
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Cellular components related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00579610.7MUC3B, MUC5AC, MUC6, MUC2

Biological processes related to Barrett's Esophagus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1digestionGO:00758610.7MUC5AC, TFF3, TFF2, TFF1
2O-glycan processingGO:01626610.6MUC2, MUC6, MUC5AC, MUC3B
3maintenance of gastrointestinal epitheliumGO:03027710.6MUC6, TFF1
4post-translational protein modificationGO:04368710.4MUC3B, MUC5AC, MUC6, MUC2

Products for genes affiliated with Barrett's Esophagus

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Sources for Barrett's Esophagus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet