MCID: BRT005
MIFTS: 53

Barth Syndrome malady

Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Blood diseases, Cardiovascular diseases categories

Aliases & Classifications for Barth Syndrome

About this section
Sources:
49OMIM, 10Disease Ontology, 11diseasecard, 21GeneReviews, 45NIH Rare Diseases, 22GeneTests, 23Genetics Home Reference, 46NINDS, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 67UniProtKB/Swiss-Prot, 24GTR, 65UMLS, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 34MedGen
See all sources

Aliases & Descriptions for Barth Syndrome:

Name: Barth Syndrome 49 10 11 21 45 22 23 46 47 12 51 36 67
3-Methylglutaconic Aciduria Type 2 23 51 24 65 67
Mga Type Ii 10 45 22 23 67
Cardioskeletal Myopathy with Neutropenia and Abnormal Mitochondria 45 23 51 67
Bths 45 23 51 67
3-Methylglutaconic Aciduria Type Ii 45 22 67
Mga2 22 51 67
Cardioskeletal Myopathy-Neutropenia 51 67
Mga Type 2 10 23
Non-Compaction of Left Ventricular Myocardium Isolated X-Linked 67
Left Ventricular Non-Compaction Isolated X-Linked 67
 
X-Linked Cardioskeletal Myopathy and Neutropenia 51
3-Alpha-Methylglutaconic Aciduria Type 2 67
3 Methylglutaconic Aciduria, Type Ii 23
Endocardial Fibroelastosis, X-Linked 22
3-Methylglutaconicaciduria Type Ii 10
3-Methylglutaconicaciduria Type 2 10
Endocardial Fibroelastosis Type 2 22
Dnajc19 Defect 23
Taz Defect 23
Invm 67
Agm2 67


Classifications:



Characteristics (Orphanet epidemiological data):

51
barth syndrome:
Inheritance: X-linked recessive; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (United States),1-9/1000000 (United Kingdom); Age of onset: Childhood; Age of death: any age


External Ids:

OMIM49 302060
Disease Ontology10 DOID:0050476
MeSH36 D056889
Orphanet51 111
UMLS via Orphanet66 C0574083
ICD10 via Orphanet28 E71.1
MESH via Orphanet37 D056889
MedGen34 C0574083

Summaries for Barth Syndrome

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NINDS:46 Barth syndrome (BTHS) is a rare, genetic disorder of lipid metabolism that primarily affects males. It is caused by a mutation in the tafazzin gene (TAZ, also called G4.5) which leads to decreased production of an enzyme required to produce cardiolipin. Cardiolipin is an essential lipid that is important in energy metabolism. BTHS, which affects multiple body systems, is considered serious. Its main characteristics often include combinations in varying degrees of cardiomyopathy (a disorder of the heart muscle leading to a poorly functioning heart), neutropenia (a reduction in the number of white blood cells which may lead to an increased risk for bacterial infections), hypotonia (reduced muscle tone), muscle weakness, undeveloped skeletal muscles, delayed growth, lack of stamina, varying degrees of physical disability, and methylglutaconic aciduria (an increase in an organic acid that results in abnormal mitochondria function). Although some with BTHS may have all of these characteristics, others may have only one or two, and, thus, are often misdiagnosed. BTHS is an X-linked genetic condition passed from mother to son through the X chromosome. A mother who is a carrier of BTHS shows no signs or symptoms of the disorder herself. On average, 50 percent of children born to a carrier mother will inherit the defective gene, but only boys will develop symptoms. All daughters born to an affected male will be carriers.

MalaCards based summary: Barth Syndrome, also known as 3-methylglutaconic aciduria type 2, is related to cardiomyopathy and myopathy, and has symptoms including hypertrophic cardiomyopathy, abnormality of neutrophils and abnormality of the musculature. An important gene associated with Barth Syndrome is TAZ (Tafazzin), and among its related pathways is Mitochondrial protein import. Affiliated tissues include heart, skeletal muscle and neutrophil.

Disease Ontology:10 A lipid metabolism disorder that has material basis in x-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin.

NIH Rare Diseases:45 Barth syndrome is a metabolic and neuromuscular disorder, occurring exclusively in males, that primarily affects the heart, immune system, and growth. it typically becomes apparent during infancy or early childhood, but the age of onset, associated symptoms and findings, and disease course varies considerably among affected individuals. the main characteristics of the condition include abnormalities of heart and skeletal muscle (cardiomyopathy and skeletal myopathy); low levels of certain white blood cells called neutrophils that help to fight bacterial infections (neutropenia); and growth retardation, potentially leading to short stature. other signs and symptoms may include increased levels of certain organic acids in the urine and blood (such as 3-methylglutaconic acid), and increased thickness of the left ventricle of the heart due to endocardial fibroelastosis, which can cause potential heart failure. it is caused by mutations in the taz gene and is inherited in an x-linked recessive manner. treatment is directed toward the specific symptoms that are apparent in each individual. last updated: 6/3/2011

Genetics Home Reference:23 Barth syndrome is a rare condition characterized by an enlarged and weakened heart (dilated cardiomyopathy), weakness in muscles used for movement (skeletal myopathy), recurrent infections due to small numbers of white blood cells (neutropenia), and short stature. Barth syndrome occurs almost exclusively in males.

OMIM:49 Barth syndrome (BTHS) is an X-linked disease conventionally characterized by dilated cardiomyopathy (CMD) with... (302060) more...

UniProtKB/Swiss-Prot:67 Barth syndrome: An X-linked disease characterized by dilated cardiomyopathy with endocardial fibroelastosis, a predominantly proximal skeletal myopathy, growth retardation, neutropenia, and organic aciduria, particularly excess of 3-methylglutaconic acid. Additional features include hypertrophic cardiomyopathy, isolated left ventricular non- compaction, ventricular arrhythmia, motor delay, poor appetite, fatigue and exercise intolerance, hypoglycemia, lactic acidosis, hyperammonemia, and dramatic late catch-up growth after growth delay throughout childhood.

Wikipedia:68 Barth syndrome (BTHS), also known as 3-Methylglutaconic aciduria type II, is an X-linkedgenetic... more...

GeneReviews summary for barth

Related Diseases for Barth Syndrome

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Diseases related to Barth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1cardiomyopathy10.7
2myopathy10.6
3neutropenia10.6
4left ventricular noncompaction10.5
5adult syndrome10.3
6williams-beuren syndrome10.3
7child syndrome10.3
8congestive heart failure10.3
9muscle disorders10.3
10metabolic syndrome x10.3
11congenital heart disease10.3
12lipid metabolism disorder10.3
13mitochondrial metabolism disease10.3
14muscle tissue disease10.3
15x-linked disease10.3
16mitochondrial disorders10.3
17kid syndrome10.3
18mitochondrial genetic disorders10.3
19young syndrome10.3
20mitochondrial cardiomyopathy10.3
21agammaglobulinemia 210.3
22noonan syndrome 110.2
23coronary heart disease 310.2
24systolic heart failure10.2
253-methylglutaconic aciduria10.2
26amino acid metabolic disorder10.2
27inborn amino acid metabolism disorder10.2
283-methylglutaconic aciduria, type v10.2
29familial isolated noncompaction of left ventricular myocardium10.1
30agammaglobulinemia 110.1
31coronary heart disease 810.1
323-methylglutaconic aciduria, type i10.1
33congenital heart defects, multiple types, 310.1
34left ventricular noncompaction 1, with or without congenital heart defects10.1
35dilated cardiomyopathy10.1
36single ventricular heart10.1
37skin disease10.1
38fatty acid oxidation disorders10.1
39septate vagina10.0LDB3, TAZ
40left-sided gallbladder9.8DTNA, LDB3, TAZ
41drug-induced hepatitis9.7DNAJC19, LDB3, TAZ
42cardiomyopathy with or without skeletal myopathy9.6DNAJC19, LDB3, TAZ, TTR
43epsilon-trimethyllysine hydroxylase deficiency8.6ANXA5, DNAJC19, DTNA, LDB3, PLA2G6, TAZ

Graphical network of the top 20 diseases related to Barth Syndrome:



Diseases related to barth syndrome

Symptoms for Barth Syndrome

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Symptoms by clinical synopsis from OMIM:

302060

Clinical features from OMIM:

302060

Symptoms:

 51
  • cardiomyopathy/hypertrophic/dilated
  • x-linked recessive inheritance
  • endocardium anomalies/fibroelastosis/endocarditis
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • polynuclear cells/neutrophils anomalies/neutropenia

HPO human phenotypes related to Barth Syndrome:

(show all 30)
id Description Frequency HPO Source Accession
1 hypertrophic cardiomyopathy hallmark (90%) HP:0001639
2 abnormality of neutrophils typical (50%) HP:0001874
3 abnormality of the musculature typical (50%) HP:0003011
4 abnormality of the endocardium typical (50%) HP:0004306
5 talipes equinovarus rare (5%) HP:0001762
6 neutropenia rare (5%) HP:0001875
7 full cheeks HP:0000293
8 mandibular prognathia HP:0000303
9 round face HP:0000311
10 macrotia HP:0000400
11 deeply set eye HP:0000490
12 motor delay HP:0001270
13 gait disturbance HP:0001288
14 x-linked recessive inheritance HP:0001419
15 failure to thrive HP:0001508
16 growth delay HP:0001510
17 congestive heart failure HP:0001635
18 hypertrophic cardiomyopathy HP:0001639
19 dilated cardiomyopathy HP:0001644
20 endocardial fibroelastosis HP:0001706
21 granulocytopenia HP:0001913
22 myopathic facies HP:0002058
23 3-methylglutaconic aciduria HP:0003535
24 exercise intolerance HP:0003546
25 skeletal myopathy HP:0003756
26 intermittent lactic acidemia HP:0004913
27 recurrent infections in infancy and early childhood HP:0005437
28 abnormal mitochondrial morphology HP:0008322
29 arrhythmia HP:0011675
30 fatigue HP:0012378

Drugs & Therapeutics for Barth Syndrome

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Drugs for Barth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
rituximabapprovedPhase 21514174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
2
AcetaminophenapprovedPhase 2799103-90-21983
Synonyms:
4'-Hydroxyacetanilide
4'-hydroxyacetanilide
4-(Acetylamino)phenol
4-Acetamidophenol
4-Acetaminophenol
4-Hydroxyacetanilide
4-Hydroxyanilid kyseliny octove
4-acetamidophenol
7 Select Acetaminophen
7 Select Childrens Pain Relief
8 Hour Pain Relief
A-Per
A.F. Anacin
AC1Q1KYJ
AC1Q1KYK
APAP
Abenol
Abensanil
Abrol
Abrolet
Acamol
Accu-Tap
Acenol
Acephen
Acertol
Aceta Elixir
Aceta Tablets
Acetaco
Acetagesic
Acetalgin
Acetaminofen
Acetaminophen
Acetaminophen (red)
Acetaminophen - Apap 8 Hour
Acetaminophen - Apap Arthritis
Acetaminophen 8 Hour
Acetaminophen 8 hour
Acetaminophen EXTRA STRENGTH
Acetaminophen Easy Tabs Extra Strength
Acetaminophen Extended Release
Acetaminophen Extra Strength
Acetaminophen Junior
Acetaminophen Maximum Strength
Acetaminophen PAIN RELIEF
Acetaminophen Rapid Release
Acetaminophen Rapid Release Extra Strength
Acetaminophen Regular Strength
Acetaminophen Uniserts
Acetaminophen arthritis pain
Acetaminophen easy tabs
Acetaminophen extra strength
Acetaminophen for children
Acetaminophen infants
Acetaminophen pain reliever fever reducer
Acetaminophen pain reliever/fever reducer
Acetaminophen-apap 8 Hour
Acetaminophene
Acetamol
Acetavance
Acetofen
Actamin
Actamin Extra
Actamin Super
Actifed Plus
Actimol
Actimol Chewable Tablets
Actimol Children'S Suspension
Actimol Infants' Suspension
Actimol Junior Strength Caplets
Actron
Afebrin
Afebryl
Aferadol
Algesidal
Algina
Algomol
Algotropyl
Allay
Alpiny
Alpinyl
Alvedon
Amadil
Aminofen
Aminofen Max
Anacin
Anacin 3
Anacin Aspirin Free
Anacin-3
Anacin-3 Extra Strength
Anadin dla dzieci
Anaflon
Analter
Anapap
Andox
Anelix
Anexsia
Anexsia 10/660
Anexsia 5/325
Anexsia 7.5/325
Anexsia 7.5/650
Anhiba
Anoquan
Anti-Algos
Antidol
Anuphen
Apacet
Apacet Capsules
Apacet Elixir
Apacet Extra Strength Caplets
Apacet Extra Strength Tablets
Apacet Regular Strength Tablets
Apadon
Apamid
Apamide
Apap
Apap Extra Strength
Apap extra strength
Aphen
Apinophen EXTRA STRENGTH
Apitrelal
Apo-Acetaminophen
Arfen
Arthralgen
Arthritis 8 Hour
Arthritis Pain
Arthritis Pain Relief
Arthritis Pain Relief temporary minor
Arthritis Pain Reliever
Asetam
Asomal
Aspac
Aspirin Free
Aspirin Free Anacin Maximum Strength Caplets
Aspirin Free Anacin Maximum Strength Gel Caplets
Aspirin Free Anacin Maximum Strength Tablets
Aspirin Free Pain Relief
Aspirin-Free Anacin
Aspirin-Free Excedrin Caplets
Asplin
Atasol
Atasol Caplets
Atasol Drops
Atasol Forte Caplets
Atasol Forte Tablets
Atasol Oral Solution
Atasol Tablets
Atralidon
Aypanal
Babies R Us Childrens Pain Relief
Babies R Us Infants Pain Relief
Babies R Us Pain Relief
Babikan
Bacetamol
Bancap
Bancap Hc
Banesin
Bayer Select
Bayer Select Allergy-Sinus
Bayer Select Head Cold
Bayer Select Headache Pain
Bayer Select Maximum Strength Headache Pain Relief Formula
Bayer Select Menstrual Multi-Symptom
Bayer Select Sinus Pain Relief
Ben-u-ron
Benmyo
Bf-paradac
Bickie-mol
Biocetamol
Bucet
Butalbital
Butapap
CCRIS 3
CHEBI:46195
Cadafen
Calapol
Calmanticold
Calonal
Calpol
Capital
Capital with Codeine
Captin
Care One Arthritis Pain Relief
Care One Arthritis Pain Relief temporary minor
Care One Pain Relief
Care One Pain Relief 8 hour
Care One Pain Relief Childrens
Care One Pain Relief childrens
Care One Pain Relief extra strength
Care One Pain Relief infants
Careone Infants Pain Relief
Careone Pain Relief
Careone Pain Relief infants
Causalon
Cefalex
Cetadol
Cetafen
Cetafen Extra
Children Acetaminophen Grape Flavored Chewable
Children'S Acetaminophen Elixir Drops
Children'S Acetaminophen Oral Solution
Children'S Tylenol Chewable
Children's Pain Relief
Childrens Accudial Pain reliever/ Fever reducer
Childrens Acetaminophen
Childrens Acetaminophen Melts
Childrens Acetaminophen Oral Suspension Grape Flavor
Childrens Aspirin Free Rapid Tabs
Childrens Chewable Acetaminophen
Childrens Chewable Mapap
Childrens Chewable Pain Reliever
Childrens Fever Reducer
Childrens Mapap
Childrens Mapap Acetaminophen
Childrens Non Aspirin
Childrens Nortemp
Childrens Pain Relief
Childrens Pain Relief Acetaminophen
Childrens Pain Relief Bubblegum
Childrens Pain Relief Grape Flavor
Childrens Pain Relief ReadyInCase
Childrens Pain Reliever
Childrens Qpap
Childrens Silapap
Childrens Tylenol
Childrens non aspirin
Circle K Pain Reliever
Claradol Codeine
Clixodyne
Co-Gesic
Cod-Acamol Forte
Codabrol
Codalgin
Codapane
Codicet
Codisal
Codisal Forte
Codoliprane
Codral Pain Relief
Cofamol
Conacetol
Concentrated Aspirin Free infants
Conrx Extra Strength
Contac Cough & Sore Throat Formula
Contra-Schmerz P
Coricidin
Coricidin D
Coricidin Sinus
Cosutone
Counteract Childrens Pain Reliever
Counteract Pain
Croix Blanche
Cuponol
Curadon
Curpol
Custodial
D oliprane
Dafalgan
Dapa
Dapa X-S
Darocet
Darvocet
Darvocet-N 50
Datril
Datril Extra-Strength
Daygrip
Demilets
Deminofen
Democyl
Demogripal
Desfebre
Dg Health Arthritis Pain Relief
Dg Health Childrens Pain Relief
Dg Health Pain Relief
Dg Health Pain Relief Infants
Dg Health Pain Relief childrens
Dg Health Pain Reliever
Dg Health Pain Reliever extra strength
Dhamol
Dhc Plus
Dial-a-gesic
Dial-alpha-gesic
Dimindol
Direct Safety Aspirin Free
Direct Safety Extra Strength Aspirin Free
Dirox
Disprol
Dol-Stop
Dolcor
Dolefin
Dolegrippin
Dolene AP-65
Dolene Ap-65
Dolgesic
Doliprane
Dolko
Dolofin Infantil
Dolofugin
Doloreduct
Dolorfug
Dolorol Forte
Dolorstop
Dolotec
Dolprone
Dorocoff
Dover Aminophen
Dresan
Dristan Cold No Drowsiness
Dristancito
Drixoral Plus
Duaneo
Dularin
Duorol
Duracetamol
Duradyne Dhc
Durapan
Dye-free Childrens Acetaminophen Grape
Dymadon
Dymadon Co
Dymadon Forte
Dypap
Ecosetol
Ed Apap
Elixodyne
Empracet
Endecon
Enelfa
Eneril
Equaline Acetaminophen infants
Equaline Arthritis
Equaline Childrens Acetaminophen
Equaline Infants Acetaminophen
Equaline Pain Relief
Equaline Pain Relief childrens
Equaline Pain Relief concentrated
Equaline Pain Relief extra strength
Equaline Pain Relief infants
Equaline Pain Relief infants concentrated
Equate Acetaminophen
Equate Arthritis Pain
Equate Childrens Acetaminophen
Equate Pain Reliever Extra Strength
Esgic
Esgic-Plus
Eu-Med
Excedrin
Excedrin Caplets
Excedrin Extra Strength Caplets
Excipain
Exdol
Exdol Strong
Extra Strength Acetaminohpen Adult Rapid Burst Cherry
Extra Strength Acetaminophen
Extra Strength Aspirin Free Pain Relief
Extra Strength Headache Relief
Extra Strength Mapap
Extra Strength Non-aspirin
Extra Strength Non-aspirin Pain Reliever
Extra Strength Pain Relief
Extra Strength Pain Relief Acetaminophen
Extra Strength Pain Reliever
Extra Strength Qpap
Extra Strength Wal-nadol
Family Wellness Acetaminophen
Fanalgic
Farmadol
Febranine
Febrectal
Febrectol
Febrex
Febricet
Febridol
Febrilix
Febrin
Febrinol
Febro-Gesic
Febrolin
Femcet
Fendon
Fensum
Fepanil
Fever All
Fever Reducing childrens
Feverall
Feverall Adults
Feverall Children
Feverall Childrens
Feverall Infants
Feverall Jr. Strength
Feverall Junior
Feverall Junior Strength
Feverall Sprinkle Caps Junior Strength
Fevor
Finimal
Finiweh
Fioricet
Fluparmol
Formu Care Pain Relief
Fortalidon P
Fortolin
Freka-cetamol
Fulton Street Market Pain Relief extra strength
Gattaphen T
Gelocatil
Geluprane
Genapap
Genapap Children'S Elixir
Genapap Children'S Tablets
Genapap Extra Strength Caplets
Genapap Extra Strength Tablets
Genapap Regular Strength Tablets
Genebs
Genebs Extra Strength Caplets
Genebs Regular Strength Tablets
Genebs X-Tra
Geralgine-P
Gesteira
Good Neighbor Pharmacy 8 Hour Pain Relief
Good Neighbor Pharmacy Childrens Pain Relief
Good Neighbor Pharmacy Pain Relief
Good Neighbor Pharmacy Pain Relief Infants
Good Neighbor Pharmacy Pain Relief Rapid Release Extra Strength
Good Neighbor Pharmacy Pain Relief childrens
Good Neighbor Pharmacy Pain Relief extra strength
Good Neighbor Pharmacy Pain Relief infants
Good Neighbor Pharmacy Pain Relief regular strength
Good Sense Pain Relief
Good Sense Pain Relief 8 hour
Good Sense Pain Relief Extra Strength
Good Sense Pain Relief arthritis pain
Good Sense Pain Relief childrens
Good Sense Pain Relief extra strength
Good Sense Pain Relief infants concentrated
Good Sense Pain Reliefchildrens childrens
Green Guard Maximum Non-aspirin
Gripin Bebe
Grippostad
Gynospasmine
Health Mart Junior Rapid Melts
Health Mart Pain Relief
Health Sense Tactinal Extra Strength
Health Sense Tactinal Regular Strength
Healthy Accents Arthritis Pain Relief
Healthy Accents Pain Relief
Healthy Accents Pain Relief childrens
Healthy Accents Pain Relief extra strength
Healthy Accents Pain Relief infants
Healthy Mama SHAKE THAT ACHE
Hedex
Helon N
Help I Have A Headache
Henry Schein Acetaminophen
Homoolan
Hy-Phen
Hycomine Compound
Hydrocet
Ildamol
Inalgex
Infadrops
Infants Acetaminophen
Infants Acetaminophen Concentrated
Infants Mapap
Infants Mapap Pain Reliever /Fever Reducer
Infants Pain Relief
Infants Pain Relief Concentrated
Infants Pain Relief concentrated
Infants Pain Reliever
Infants Silapap
Infants Tylenol
Infants concentrated aspirin free
Infants' Feverall
Influbene N
Injectapap
Intensin
Janupap
Jin Gang
Junior Acetaminophen
Junior Aspirin Free Rapid Tabs
Junior Disprol
Junior Pain Relief
Junior Rapid Melts Grape
Junior Strength Acetaminophen
Junior Strength Pain Relief
Junior Strength Pain Reliever
Junior Strength Pain Reliever Grape
KBio1_000660
Kataprin
Kinder Finimal
Kirkland Signature Acetaminophen adult extra strength
Kirkland Signature Arthritis Pain
Kirkland Signature Infants Pain Relief
Kirkland Signature Non Aspirin Extra Strength
Kirkland Signature Pain Relief
Korum
Kratofin simplex
L024125
Labamol
Leader 8 Hour Pain Reliever
Leader Arthritis Pain
Leader Arthritis Pain Reliever
Leader Childrens Pain Reliever
Leader Extra Strength Pain Relief
Leader Pain Relief 8 HR
Leader Pain Relief childrens
Leader Pain Reliever
Leader Pain Reliever childrens
Leader Pain Reliever extra strength
Leader Pain Reliever infants
Leader Pain Reliever infants concentrated
Lekadol
Lemgrip
Lemsip
Lestemp
 
Lil Drug Store Pain Reliever Extra Strength
Liqiprine
Liquagesic
Liquigesic Co
Liquiprin
Liquiprin Children'S Elixir
Liquiprin Infants" Drops
Little Fevers By Little Remedies
Little Fevers Childrens Fever Pain Reliever
Little Fevers Infant Berry Fever/pain Reliever
Little Fevers Infant Grape Fever/pain Reliever
Lonarid
Lonarid Mono
Lorcet-Hd
Lortab
Lupocet
Lyteca
Lyteca Syrup
Magnidol
Malex N
Malgis
Malidens
Mapap
Mapap Arthritis Pain
Mapap Extra Strength
Mapap childrens
Mapap infants concentrated
Maxadol
Medi First Plus Non-aspirin
Medi First Plus Non-aspirin Extra Strength
Medi-first Non-aspirin
Medi-first Non-aspirin Extra Strength
Medicine Shoppe Arthritis Pain Reliever
Medigesic Plus
Medinol Paediatric
Medique Apap
Medique Apap Extra Strength
Medline Acetaminophen
Medocodene
Melabon Infantil
Members Mark Acetaminophen
Members Mark Arthritis Pain
Mexalen
Midol Maximum Strength
Midol PM Night Time Formula
Midol Regular Strength
Midol Teen Formula
Migraleve Yellow
Minafen
Minoset
Miralgin
Momentum
Mono Praecimed
Moore Medical Extra Strength Non Aspirin
Moore Medical Non Aspirin
Multin
N-(4-Hydroxyphenyl)acetamide
N-Acetyl-4-aminophenol
N-Acetyl-p-aminophenol
N-acetyl-p-aminophenol
NAPA
NCX 701
NEBS
NSC3991
Naldegesic
Napafen
Napap
Naprinol
Nealgyl
Nebs
Neo-Fepramol
NeoCitran
Neodol
Neodolito
Neopap
Neotrend
Neuridon
New Cortal for Children
NilnOcen
Nina
No-Febril
Nobedon
Nodolex
Non Aspirin Childrens
Non Aspirin Extra Strength
Non-aspirin
Noral
Norcet
Norco
Nortemp
O-Acetaminophenol
Ofirmev
Ohm 8 Hour Pain Reliever/fever Reducer
Oltyl
Oralgan
Oraphen-PD
Ortensan
Oxycet
Oxycocet
Oxycodone 2.5/Apap 500
Oxycodone 5/Apap 500
PCM Paracetamol Lichtenstein
Paceco
Pacemo
Pacemol
Pacet
Pacimol
Paedialgon
Paedol
Pain Relief
Pain Relief 8 Hr
Pain Relief 8 hour
Pain Relief Acetaminophen Extra Strength
Pain Relief Childrens
Pain Relief ES
Pain Relief Extra Strength
Pain Relief Infants
Pain Relief Regular Strength
Pain Relief childrens
Pain Relief concentrated infants
Pain Relief extra strength
Pain Relief infants
Pain Relief regular strength
Pain Reliever
Pain Reliever Extra Strength
Pain Reliever Extra Strength (Leader)
Pain Reliever Fever Reducer childrens
Pain Reliever Infants
Pain Reliever Rapid Release
Pain Reliever childrens
Pain Reliever extra strength
Pain Reliever infants
Painex
Paldesic
Pamol
Panacete
Panadeine
Panadeine Co
Panadiene
Panado-Co
Panado-Co Caplets
Panadol
Panadol Extra Strength
Panadol Junior Strength Caplets
Panadol Maximum Strength Caplets
Panadol Maximum Strength Tablets
Panale ve
Panaleve
Panamax
Panasorb
Panasorbe
Panets
Panex
Panodil
Panofen
Pantalgin
Papa-Deine
Papa-Deine #3
Papa-Deine #4
Para-Suppo
Para-Tabs
Paracemol
Paracenol
Paracet
Paracetamol
Paracetamol AL
Paracetamol Antipanin P
Paracetamol BC
Paracetamol Basics
Paracetamol DC
Paracetamol Dr. Schmidgall
Paracetamol Fecofar
Paracetamol Genericon
Paracetamol Hanseler
Paracetamol Harkley
Paracetamol Heumann
Paracetamol Hexal
Paracetamol Italfarmaco
Paracetamol Nycomed
Paracetamol PB
Paracetamol Raffo
Paracetamol Ratiopharm
Paracetamol Rosch
Paracetamol Saar
Paracetamol SmithKline Beecham
Paracetamol Stada
Paracetamol Winthrop
Paracetamol von ct
Paracetamole
Paracetamolo
Paracetamolum
Paracetanol
Paracetol
Paracin
Paracod
Paracodol
Parador
Paradrops
Parakapton
Parake
Paralen
Paralief
Paralink
Paralyoc
Paramol
Paramolan
Paranox
Parapan
Parasedol
Parasin
Paraspen
Parcetol
Parelan
Parmol
Parogal
Paroma
Pasolind
Pasolind N
Pe-Tam
Pediacare Childrens Fever Reducer Pain Reliever Cherry
Pediacare Childrens Fever Reducer Pain Reliever Dye Free
Pediacare Childrens Fever Reducer Pain Reliever Grape
Pediacare Infant Fever Pain Reliever
Pediacare Infants Fever Reducer Cherry
Pediacare Infants Fever Reducer Dye Free
Pediacare Infants Fever Reducer Grape
Pediacare Single Dose Fever Reducer
Pediapirin
Pediatrix
Pedric
Percocet
Percocet-5
Percocet-Demi
Percogesic with Codeine
Perdolan Mono
Perfalgan
Pharbetol
Pharbetol Regular strength
Phenaphen
Phenaphen Caplets
Phenaphen W/Codeine
Phendon
Phenipirin
Phogoglandin
Phrenilin
Phrenilin Forte
Physicianscare Non Aspirin Extra Strength
Pinex
Piramin
Pirinasol
Plicet
Plus Pharma Pain Reliever,Fever Reducer 325 mg
Pluspharma Extra Strength PAIN RELIEVER,FEVER REDUCER 500 mg
Polmofen
Powerful Pain Medicine
Predimol
Predualito
Preferred Plus Arthritis Pain
Preferred Plus Extra Strength Pain Relief
Premier Value Arthritis 8 Hour
Premier Value Arthritis Pain Reliever
Prestwick_13
Prodol
Prompt
Prontina
Propacet
Propacet 100
Proval #3
Puernol
Pulmofen
Pyregesic-C
Pyrigesic
Pyrinazine
Pyromed
Qpap Infants Drops
Quality Choice Extra Strength Pain Relief
Quiet World
Rapid Comfort Extra Strength Non Aspirin
Rapid Comfort Non Aspirin
Rapid Release Acetaminophen
Redutemp
Regular Strength Pain Relief
Regular Strength Pain Reliever
Regular Strength Qpap
Reliv
Remedol
Rexall Arthritis Pain
Rexall Pain Relief
Rhinex D-Lay Tablets
Ringl
Rivalgyl
Robigesic
Robitussin Night Relief
Rockamol Plus
Rounox
Roxicet
Roxicet 5/500
Roxilox
RubieMol
Rubophen
Rugby Acetaminophen
Rupemol
Rx Act Pain Relief
Rx Act Pain Relief 8 Hr
Rx Act Pain Relief Extra Strength
Rx Act Pain Relief Rapid Release
Rx Act Pain Relief extra strength
Rx Act Pain Relief infants
Rx Act Pain Relief regular strength
SK-Apap
SPBio_002836
Salzone
Sanicet
Sanicopyrine
Scanol
Scentalgyl
Scherzatabletten Rezeptur 534
Schmerzex
Sedalito
Sedapap
Semolacin
Servigesic
Seskamol
Setakop
Setamol
Setol
Severe Sinus Congestion
Shoprite Acetaminophen
Shoprite Arthritis Pain
Shoprite Childrens Acetaminophen
Shoprite Infants Acetaminophen
Shoprite Pain Relief
Sifenol
Simply Right Acetaminophen
Simply Right Arthritis Pain
Sinaspril
Sine-Off Sinus Medicine Caplets
Sinedol
Sinmol
Sinubid
Smart Sense Arthritis Pain Relief
Smart Sense Childrens Pain Relief
Smart Sense Infants Pain Relief
Smart Sense Pain Relief
Smart Sense Pain Relief 8 hour
Smart Sense Pain Relief Extra Strength
Smart Sense Pain Relief childrens
Smart Sense Pain Relief extra strength
Smart Sense Pain Relief infants
Snaplets-FR
Sohmed Extra Strength
Spalt N
Spalt fur die nacht
St Joseph Aspirin-Free
St Joseph Aspirin-Free for Children
St. Joseph Cold Tablets for Children
St. Joseph Fever Reducer
Stanback
Stopain
Sudafed Severe Cold Formula
Sudafed Sinus
Sunetheton
Sunmark 8 Hour Pain Relief
Sunmark Arthritis 8 Hour
Sunmark Arthritis Pain Relief
Sunmark Arthritis Pain Reliever
Sunmark Junior Rapid Melts
Sunmark Pain Relief Extra Strength
Sunmark Pain Reliever
Sunmark Pain Reliever Infants
Sunmark Pain Reliever extra strength
Sunmark Pain Reliever infants
Supac
Supadol mono
Supofen
Suppap
Suppap-120
Suppap-325
Suppap-650
Supramol-M
Swift Aypanal Extra
Synalgos-Dc-A
TYL
Tabalgin
Tachiprina
Talacen
Tapanol
Tapanol Extra Strength Caplets
Tapanol Extra Strength Tablets
Tapar
Tavist Allergy/Sinus/Headache
Tazamol
Temlo
Tempanal
Tempra
Tempra Caplets
Tempra Chewable Tablets
Tempra D.S
Tempra Drops
Tempra Syrup
Tencon
Termacet
Termalgin
Termalgine
Termofren
TheraFlu
Tibinide
Tibizide
Tiffy
Tisin
Tisiodrazida
Titralgan
Tizide
Tocris-1706
Topcare 8 Hour Pain Relief
Topcare Arthritis Pain
Topcare Arthritis Pain Relief
Topcare Arthritis Pain Relief Temporary Minor
Topcare Childrens Pain Relief
Topcare Fever Reducer
Topcare Infants Pain Relief
Topcare Pain Relief
Topcare Pain Relief Extra Strength
Topcare Pain Relief Infants
Topcare Pain Relief Rapid Release
Topcare Pain Relief extra strength
Topcare Pain Relief extra strength easy to swallow
Topco Arthritis 8 Hour
Toximer P
Tralgon
Treupel N
Treupel mon
Treuphadol
Triad
Triaminic Fever Reducer
Triaminic Infants Fever Reducer Pain Reliever - Bubblegum
Triaminic Infants Fever Reducer Pain Reliever - Grape
Triaminic Sore Throat Formula
Triaprin
Tricoton
Tussapap
Ty lenol
Tycolet
Tylenol
Tylenol (TN)
Tylenol Allergy Sinus
Tylenol Arthritis Extended Relief
Tylenol Arthritis Pain
Tylenol Caplets
Tylenol Children'S Chewable Tablets
Tylenol Children'S Elixir
Tylenol Children'S Suspension Liquid
Tylenol Cold Sore Throat Extra Strength
Tylenol Drops
Tylenol Elixir
Tylenol Extra Strength
Tylenol Extra Strength Adult Liquid Pain Reliever
Tylenol Extra Strength Caplets
Tylenol Extra Strength Gelcaps
Tylenol Extra Strength Tablets
Tylenol Gelcaps
Tylenol Infants Drops
Tylenol Infants" Suspension Drops
Tylenol Junior Strength Caplets
Tylenol Junior Strength Chewable Tablets
Tylenol Regular Strength
Tylenol Regular Strength Caplets
Tylenol Regular Strength Tablets
Tylenol SORE THROAT
Tylenol Tablets
Tylex
Tylex CD
Tylo Extra Strength
Tylol
Tylox
Tylox-325
Tymol
Ultracet
Upsanol
Utragin
Valadol
Valgesic
Valorin
Valorin Extra
Vanquish
Veralgina
Vermidon
Verpol
Viclor Richet
Vicodin
Vicodin Es
Vicodin Hp
Vips
Viruflu
Vivimed
Volpan
Welby Health Acetaminophen
Wygesic
Xl-dol
Zatinol
Zee Unaspirin ES
Zolben
alpha-Per
p-(Acetylamino)phenol
p-Acetamidophenol
p-Acetaminophenol
p-Acetylaminophenol
p-Hydroxyacetanilide
p-Hydroxyphenolacetamide
p-acetamidophenol
p-acetaminophenol
p-hydroxyacetanilide
p-hydroxyphenolacetamide
3
PromethazineapprovedPhase 219260-87-74927
Synonyms:
(2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine
(Dimethylamino-2-propyl-10-phenothiazine hydrochloride
10-(2-(Dimethylamino)-2-methylethyl)phenothiazine
10-(2-(Dimethylamino)propyl)phenothiazine
10-(2-Dimethylaminopropyl)phenothiazine
10-[2-(Dimethylamino)propyl]phenothiazine
10-[2-(dimethylamino)Propyl]phenothiazine
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl- (9CI)
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+)
3277 RP
3389 R.p.
38878-40-9
4-27-00-01253 (Beilstein Handbook Reference)
4182 R.p.
60-87-7
73745-50-3
A-91033
AB00053535
AC-15939
AC1L1J92
Antiallersin
Aprobit
Avomine
BPBio1_000744
BRN 0088554
BSPBio_000676
BSPBio_002777
C07404
CCRIS 7056
CHEBI:8461
CHEMBL643
CID4927
Camergan
D00494
DB01069
Dimapp
Dimethylamino-isopropyl-phenthiazin
Dimethylamino-isopropyl-phenthiazin [German]
Diphergan
Diprazin
Diprazine
Diprozin
DivK1c_000005
EINECS 200-489-2
Fargan
Fenazil
Fenetazina
Fenetazine
Genphen
HMS2089E08
HSDB 3173
Hiberna
Histargan
IDI1_000005
Iergigan
InChI=1/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
Isophenergan
Isopromethazine
KBio1_000005
KBio2_001348
KBio2_003916
KBio2_006484
KBio3_001997
KBioGR_001697
KBioSS_001348
L000495
LS-264
Lercigan
Lergigan
Lilly 01516
Lilly 1516
Lopac0_000899
Metaryl
MolPort-001-783-684
N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine
N,N,α-trimethyl-10H-phenothiazine-10-ethanamine
N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine
N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride
N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine
N-(2'-dimethylamino-2'-Methyl)ethylphenothiazine
 
N-Dimethylamino-2-methylethyl thiodiphenylamine
NCGC00015817-10
NCGC00089735-02
NCGC00089735-03
NCI-C60673
NCI60_001878
NINDS_000005
NSC 30321
NSC30321
Oprea1_758749
PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3)
Pelpica
Phargan
Phenadoz
Phenargan
Phenergan
Phenerzine
Phenoject-50
Phensedyl
Pilothia
Pilpophen
Pipolphene
Prestwick0_000888
Prestwick1_000888
Prestwick2_000888
Prestwick3_000888
Pro-50
Proazaimine
Proazamine
Procit
Promacot
Promazinamide
Promergan
Promesan
Prometasin
Prometazin
Prometazina
Prometazina [INN-Spanish]
Prometazine
Prometh
Promethacon
Promethaine
Promethazin
Promethazine
Promethazine (JAN/INN)
Promethazine Hydrochloride
Promethazine [INN:BAN]
Promethazine hydrochloride
PromethazineHcl
Promethazinum
Promethazinum [INN-Latin]
Promethegan
Promethiazine
Promezathine
Prorex
Protazine
Prothazin
Prothazine
Provigan
Pyrethia
Pyrethiazine
RP 3277
Remsed
Romergan
Rumergan
SKF 1498
SPBio_000799
SPBio_002895
Sominex
Spectrum2_000840
Spectrum3_001019
Spectrum4_001149
Spectrum5_000977
Spectrum_000868
Tanidil
Thiergan
UNII-FF28EJQ494
Valergine
Vallergine
WLN: T C666 BN ISJ B1Y1&N1&1
WY 509
Zipan-25
promethazine
4
PrednisoneapprovedPhase 2120853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
5
DiphenhydramineapprovedPhase 219258-73-1, 147-24-03100
Synonyms:
147-24-0
147-24-0 (HYDROCHLORIDE)
2-(Benzhydryloxy)-N,N-dimethylethylamine
2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride
2-(Diphenylmethoxy)-N,N-dimethylethylamine
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-Diphenylmethoxy-N,N-dimethylethylamine
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine
2-benzhydryloxy-N,N-dimethylethanamine
2-benzhydryloxyethyl-N,N-dimethylammonium
2-diphenylmethoxy-N,N-demthylethanamine
2PM
58-73-1
88637-37-0 (citrate (1:1))
AB00053460
AC-13704
AC1L1F65
AKOS003658554
Aleryl
Alledryl
Aller-Med
Allerdryl
Allergan
Allergan B
Allergeval
Allergical
Allergina
Allergival
Allergy
Allergy Relief
Allermax Caplets
Allernix
Amidryl
Antistominum
Antitussive
Antomin
Automin
BENADRYL HCl
BIDD:GT0152
BPBio1_000275
BRD-K47278471-003-05-7
BRN 1914136
BSPBio_000249
BSPBio_002219
Bagodryl
Banophen
Banophen Caplets
Baramine
Beldin
Belix
Ben-allergin
Bena
Benachlor
Benadrin
Benadryl
Benadryl (hydrochloride)
Benadryl Allergy
Benapon
Bendylate
Benhydramin
Benodin
Benodine
Benylan
Benylin
Benzantin
Benzantine
Benzhydramine
Benzhydraminum
Benzhydril
Benzhydroamina
Benzhydryl
Betramin
CAS-147-24-0
CCRIS 1959
CHEBI:127629
CHEBI:4636
CHEMBL657
CID3100
CPD-10890
Childrens Allergy Relief
Childrens Wal-dryl Allergy
Compoz
D00300
DB01075
DB06975
DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE
Dabylen
Debendrin
Dermistina
Dermodrin
Desentol
Diabenyl
Diabylen
Dibendrin
Dibenil
Dibondrin
Difedryl
Difenhidramina
Difenhidramina [INN-Spanish]
Difenhydramin
Difenhydramine
Difenidramina
Difenidramina [Italian]
Dihidral
Dimedrol
Dimedrol base
Dimedrolum
Dimedryl
Dimehydrinate
Dimethylamine benzhydryl ester
Diphamine
Diphantine
Diphen
Diphen Cough
Diphenhist
Diphenhist Captabs
 
Diphenhydramine
Diphenhydramine (JP15/INN)
Diphenhydramine Base
Diphenhydramine HCl
Diphenhydramine Hydrochloride
Diphenhydramine Salicylate
Diphenhydramine [INN:BAN:JAN]
Diphenhydraminum
Diphenhydraminum [INN-Latin]
Diphenylhydramin
Diphenylhydramine
DivK1c_000368
Dobacen
Dormarex 2
Dryistan
Drylistan
Dylamon
EINECS 200-396-7
Etanautine
FAR 90X2
Genahist
HMS2089E06
HSDB 3066
Help I Cant Sleep
Histaprin
Histaxin
Hyadrine
Hydramine
Hyrexin
I14-6749
IDI1_000368
Ibiodral
Insomnal
KBio1_000368
KBio2_001460
KBio2_004028
KBio2_006596
KBio3_001439
KBioGR_001099
KBioSS_001460
L000227
LS-68208
Lopac-D-3630
Lopac0_000377
MLS002222276
Medidryl
Mephadryl
MolPort-001-783-508
N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
N-(Benzhydryloksy-etylo)dwumetyloamina
N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]
N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE
NCGC00015335-01
NCGC00015335-02
NCGC00015335-03
NCGC00015335-10
NCGC00024414-03
NCGC00024414-04
NCI60_002916
NCI60_022782
NINDS_000368
NSC665800
Nausen
Nervine Nighttime Sleep-Aid
Nightime Sleep Aid
North Antihistamine
Novamina
Nytol QuickCaps
Nytol Quickcaps
Nytol Quickgels
O-Benzhydryldimethylaminoethanol
O-benzhydryldimethylaminoethanol
Oprea1_254625
PM 255
Prestwick0_000065
Prestwick1_000065
Prestwick2_000065
Prestwick3_000065
Probedryl
Restamin
Restamin (TN)
Rigidil
S51
SMR001307259
SPBio_000961
SPBio_002170
STK103720
STOCK2S-94461
Siladryl
Silphen
Sleep-Eze D
Sleep-Eze D Extra Strength
Spectrum2_000961
Spectrum3_000400
Spectrum4_000520
Spectrum5_000915
Spectrum_000980
Syntedril
Syntodril
TL8003758
Twilite Caplets
UNII-8GTS82S83M
Unisom
Unisom Sleepgels Maximum Strength
Zzzquil
Zzzsleep
alpha-(2-Dimethylaminoethoxy)diphenylmethane
beta-Dimethylamino-aethyl-benzhydryl-aether
beta-Dimethylamino-aethyl-benzhydryl-aether [German]
beta-Dimethylaminoethanol diphenylmethyl ether
beta-Dimethylaminoethyl benzhydryl ether
beta-Dimethylaminoethylbenzhydrylether
beta-dimethylaminoethyl benzhydryl ether
diphenhydramine
nchembio747-comp18
β-dimethylaminoethyl benzhydryl ether
6methicillin142
7Coagulase10

Interventional clinical trials:

idNameStatusNCT IDPhase
1START: Sensipar Treatment Algorithm to Reach K/DOQI Targets in Chronic Kidney Disease Subjects With Secondary HyperparathyroidismCompletedNCT00132431Phase 4
2Effects of Vaporized Marijuana on Neuropathic PainCompletedNCT01037088Phase 1, Phase 2
3Resistance Exercise in Barth SyndromeRecruitingNCT01629459Phase 2
4Rituximab in Patients With Relapsed or Refractory TTP-HUSRecruitingNCT00531089Phase 2
5PTC299 for Treatment of Neurofibromatosis Type 2SuspendedNCT00911248Phase 2
6Exercise Training in Barth SyndromeCompletedNCT01194141
7Prospective Study Into the Performance of the MicroPhage S. Aureus/MSSA/MRSA Test Direct From Blood Culture PositivesCompletedNCT01184339
8Heart and Muscle Metabolism in Barth SyndromeRecruitingNCT01625663
9North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)RecruitingNCT01694940
10Exercise in Genetic Cardiovascular ConditionsRecruitingNCT02549664

Search NIH Clinical Center for Barth Syndrome


Cochrane evidence based reviews: Barth Syndrome

Genetic Tests for Barth Syndrome

About this section

Genetic tests related to Barth Syndrome:

id Genetic test Affiliating Genes
1 3-Methylglutaconic Aciduria Type 222 24 TAZ

Anatomical Context for Barth Syndrome

About this section

MalaCards organs/tissues related to Barth Syndrome:

33
Heart, Skeletal muscle, Neutrophil, Eye, Pituitary, Skin, Testes

Animal Models for Barth Syndrome or affiliated genes

About this section

Publications for Barth Syndrome

About this section

Articles related to Barth Syndrome:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
A Novel TAZ Gene Mutation and Mosaicism in a Polish Family with Barth Syndrome. (25776009)
2015
2
The mitochondrial quality control protein yme1 is necessary to prevent defective mitophagy in a yeast model of barth syndrome. (25688091)
2015
3
Cardiolipin metabolism and its causal role in the etiology of the inherited cardiomyopathy Barth syndrome. (26415690)
2015
4
Cardiolipin fingerprinting of leukocytes by MALDI-TOF/MS as a screening tool for Barth syndrome. (26144817)
2015
5
Intra-individual plasticity of the TAZ gene leading to different heritable mutations in siblings with Barth syndrome. (25782672)
2015
6
Taste perception and sensory sensitivity: Relationship to feeding problems in boys with Barth Syndrome. (26191532)
2015
7
Your heart on a chip: iPSC-based modeling of Barth-syndrome-associated cardiomyopathy. (24996164)
2014
8
Pharmacogenomic considerations in the treatment of the pediatric cardiomyopathy called Barth syndrome. (25185984)
2014
9
Clinical laboratory studies in Barth Syndrome. (24751896)
2014
10
Barth syndrome. (23843353)
2013
11
Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation. (23523468)
2013
12
New clinical and molecular insights on Barth syndrome. (23409742)
2013
13
Successful mechanical circulatory support for 251 days in a child with intermittent severe neutropenia due to Barth syndrome. (23190323)
2013
14
Barth syndrome in a female patient. (22410210)
2012
15
The Barth Syndrome Registry: distinguishing disease characteristics and growth data from a longitudinal study. (23045169)
2012
16
The cellular and molecular mechanisms for neutropenia in Barth syndrome. (22023389)
2012
17
Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. (21068380)
2011
18
Eponym: Barth syndrome. (21947198)
2011
19
Impaired cardiac reserve and severely diminished skeletal muscle Oa88 utilization mediate exercise intolerance in Barth syndrome. (21873497)
2011
20
Barth syndrome: an X-linked cause of fetal cardiomyopathy and stillbirth. (20812380)
2010
21
Dysmorphology of Barth syndrome. (19648820)
2009
22
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. (19962311)
2009
23
Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome. (19164547)
2009
24
Psychosocial Functioning in Youth with Barth Syndrome. (20808735)
2009
25
The cardiolipin transacylase, tafazzin, associates with two distinct respiratory components providing insight into Barth syndrome. (18799610)
2008
26
Mitral annuloplasty in an infant with Barth syndrome and severe mitral insufficiency: first case report and determination of annular diameter. (18954662)
2008
27
Cardiomyopathy of unknown etiology: Barth syndrome unrecognized. (19037987)
2008
28
Prevalence of Barth syndrome in adult left ventricular hypertrabeculation / noncompaction. (18365900)
2008
29
Gene symbol: TAZ. Disease: Barth syndrome. (18846664)
2008
30
New insights into the regulation of cardiolipin biosynthesis in yeast: implications for Barth syndrome. (16904369)
2007
31
Barth syndrome is associated with a cognitive phenotype. (17353728)
2007
32
Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. (16055927)
2006
33
A zebrafish model of human Barth syndrome reveals the essential role of tafazzin in cardiac development and function. (16794186)
2006
34
Barth syndrome presenting with acute metabolic decompensation in the neonatal period. (16906470)
2006
35
A Drosophila model of Barth syndrome. (16855048)
2006
36
Cardiac and clinical phenotype in Barth syndrome. (16847078)
2006
37
Barth syndrome without 3-methylglutaconic aciduria. (15124852)
2004
38
The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome. (15304507)
2004
39
Linoleic acid supplementation of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment. (12562862)
2003
40
Normal pituitary function in a Japanese patient with Barth syndrome. (11808885)
2002
41
Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. (12112112)
2002
42
Cardiolipin deficiency in X-linked cardioskeletal myopathy and neutropenia (Barth syndrome, MIM 302060): a study in cultured skin fibroblasts. (12410207)
2002
43
Quantitative and compositional study of cardiolipin in platelets by electrospray ionization mass spectrometry: application for the identification of Barth syndrome patients. (12194913)
2002
44
Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. (11238270)
2001
45
Defective remodeling of cardiolipin and phosphatidylglycerol in Barth syndrome. (11118295)
2000
46
X-linked cardioskeletal myopathy and neutropenia (Barth syndrome)-MIM 302060. (10484787)
1999
47
Barth syndrome may be due to an acyltransferase deficiency. (9259571)
1997
48
Mutation characterization and genotype-phenotype correlation in Barth syndrome. (9345098)
1997
49
Barth syndrome: clinical features and confirmation of gene localisation to distal Xq28. (8434619)
1993
50
Mapping of the locus for X-linked cardioskeletal myopathy with neutropenia and abnormal mitochondria (Barth syndrome) to Xq28. (1998334)
1991

Variations for Barth Syndrome

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UniProtKB/Swiss-Prot genetic disease variations for Barth Syndrome:

67
id Symbol AA change Variation ID SNP ID
1TAZp.Arg94SerVAR_014110
2TAZp.Cys118ArgVAR_014111
3TAZp.Gly197ArgVAR_014112
4TAZp.Gly240ArgVAR_068434

Clinvar genetic disease variations for Barth Syndrome:

5 (show all 26)
id Gene Variation Type Significance SNP ID Assembly Location
1TAZTAZ, IVS2, G-A, -1single nucleotide variantPathogenic
2TAZNM_000116.4(TAZ): c.153C> G (p.Tyr51Ter)single nucleotide variantPathogenicrs104894941GRCh37Chr X, 153640466: 153640466
3TAZTAZ, IVS2, G-C, -1single nucleotide variantPathogenic
4TAZTAZ, 1-BP INSinsertionPathogenic
5TAZTAZ, 1-BP DELdeletionPathogenic
6TAZNM_000116.4(TAZ): c.589G> A (p.Gly197Arg)single nucleotide variantPathogenicrs132630277GRCh37Chr X, 153648376: 153648376
7TAZTAZ, IVS1, G-C, +5single nucleotide variantPathogenic
8TAZTAZ, IVS3, G-A, +110single nucleotide variantPathogenic
9TAZNM_000116.4(TAZ): c.352T> C (p.Cys118Arg)single nucleotide variantPathogenicrs104894937GRCh37Chr X, 153641886: 153641886
10TAZTAZ, IVS1, A-G, -2single nucleotide variantPathogenic
11TAZNM_000116.4(TAZ): c.280C> A (p.Arg94Ser)single nucleotide variantPathogenicrs104894942GRCh37Chr X, 153641585: 153641585
12TAZTAZ, 4-BP DEL, AGTGdeletionPathogenic
13TAZNM_000116.4(TAZ): c.647-1G> Csingle nucleotide variantPathogenicrs587776741GRCh37Chr X, 153648550: 153648550
14TAZNM_000116.4(TAZ): c.347G> A (p.Gly116Asp)single nucleotide variantLikely pathogenicrs727504327GRCh37Chr X, 153641881: 153641881
15NC_000023.10: g.(?_153640181)_(153641904_?)deldeletionLikely pathogenicGRCh37Chr X, 153640181: 153641904
16TAZNM_000116.4(TAZ): c.710_711delTG (p.Val237Alafs)deletionPathogenicrs727504394GRCh37Chr X, 153649007: 153649008
17TAZNM_000116.4(TAZ): c.647G> T (p.Gly216Val)single nucleotide variantLikely pathogenicrs727504431GRCh37Chr X, 153648551: 153648551
18TAZNM_000116.4(TAZ): c.718G> A (p.Gly240Arg)single nucleotide variantPathogenicrs387907218GRCh37Chr X, 153649015: 153649015
19TAZNM_000116.4(TAZ): c.208C> T (p.Gln70Ter)single nucleotide variantLikely pathogenicrs397515738GRCh37Chr X, 153640521: 153640521
20TAZNM_000116.4(TAZ): c.328T> C (p.Ser110Pro)single nucleotide variantLikely pathogenicrs397515739GRCh37Chr X, 153641862: 153641862
21TAZNM_000116.4(TAZ): c.307T> C (p.Cys103Arg)single nucleotide variantLikely pathogenicrs397515740GRCh37Chr X, 153641841: 153641841
22TAZNM_000116.4(TAZ): c.310T> C (p.Phe104Leu)single nucleotide variantPathogenicrs397515741GRCh37Chr X, 153641844: 153641844
23TAZNM_000116.4(TAZ): c.590G> A (p.Gly197Glu)single nucleotide variantLikely pathogenicrs397515746GRCh37Chr X, 153648377: 153648377
24TAZNM_000116.4(TAZ): c.700-1G> Asingle nucleotide variantLikely pathogenicrs397515747GRCh37Chr X, 153648996: 153648996
25TAZNM_000116.4(TAZ): c.718G> C (p.Gly240Arg)single nucleotide variantPathogenicrs387907218GRCh37Chr X, 153649015: 153649015
26TAZNM_000116.4(TAZ): c.823C> T (p.Gln275Ter)single nucleotide variantLikely pathogenicrs397515750GRCh37Chr X, 153649287: 153649287

Expression for genes affiliated with Barth Syndrome

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Search GEO for disease gene expression data for Barth Syndrome.

Pathways for genes affiliated with Barth Syndrome

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Pathways related to Barth Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.9DNAJC19, TAZ, TOMM40

GO Terms for genes affiliated with Barth Syndrome

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Cellular components related to Barth Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell projectionGO:00429959.5ANXA5, DTNA
2Z discGO:00300189.3ANXA5, LDB3
3sarcolemmaGO:00423839.2ANXA5, DTNA
4protein complexGO:00432349.0DNAJC19, DTNA, TTR

Biological processes related to Barth Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cardiolipin acyl-chain remodelingGO:003596510.3PLA2G6, TAZ
2cardiolipin biosynthetic processGO:003204910.2PLA2G6, TAZ
3glycerophospholipid biosynthetic processGO:00464749.9PLA2G6, TAZ
4skeletal muscle tissue developmentGO:00075199.8TAZ, ZBTB18
5protein targeting to mitochondrionGO:00066269.1DNAJC19, TOMM40
6protein import into mitochondrial matrixGO:00301508.9DNAJC19, TOMM40

Sources for Barth Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet