MCID: BRT004
MIFTS: 47

Bartter Disease malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Endocrine diseases, Ear diseases, Fetal diseases

Aliases & Classifications for Bartter Disease

About this section
Sources:
11Disease Ontology, 13DISEASES, 25Genetics Home Reference, 27GTR, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 35LifeMap Discovery®, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Bartter Disease:

Name: Bartter Disease 35 11 25 13 68
Bartter Syndrome 48 25 54 27 39
Bartter's Syndrome 11 48 25
Aldosteronism with Hyperplasia of the Adrenal Cortex 11 25
Renal Tubular Normotensive Hypokalemic Alkalosis with Hypercalciuria 54
Juxtaglomerular Hyperplasia with Secondary Aldosteronism 25
 
Salt-Losing Tubular Disorder, Henle's Loop Type 54
Salt-Wasting Tubulopathy, Henle's Loop Type 54
Hypokalemic Alkalosis with Hypercalciuria 48
Potassium Wasting 48
Bartters Syndrome 50

Characteristics:

Orphanet epidemiological data:

54
bartter syndrome:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Sweden),1-9/100000 (Kuwait); Age of onset: Adolescent,Adult,Antenatal,Childhood,Infancy,Neonatal; Age of death: normal life expectancy

Classifications:

Orphanet: 54 
Rare renal diseases


External Ids:

Disease Ontology11 DOID:445
ICD1030 E26.81
ICD9CM32 255.13
MeSH39 D001477
NCIt45 C34412
Orphanet54 ORPHA112
MESH via Orphanet40 D001477
UMLS via Orphanet69 C0004775
ICD10 via Orphanet31 E26.8

Summaries for Bartter Disease

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NIH Rare Diseases:48 Bartter syndrome is a group of similar kidney disorders that cause an imbalance of potassium, sodium, chloride, and other molecules in the body. in some cases, the condition manifests before birth with increased amniotic fluid surrounding the affected fetus (polyhydramnios). affected infants typically do not grow and gain weight as expected (failure to thrive). dehydration, constipation and increased urine production result from losing too much salt (sodium chloride) in the urine, and weakening of the bones can occur due to excess loss of calcium. low levels of potassium in the blood (hypokalemia) can cause muscle weakness, cramping, and fatigue. bartter syndrome is caused by mutations in any one of at least 5 genes and is usually inherited in an autosomal recessive manner. the different types of bartter syndrome are classified according to the age of onset, severity, and the specific gene that causes the condition. treatment depends on the type of the syndrome present but chiefly focuses on restoring and maintaining the proper balance of fluids and electrolytes in the body. last updated: 9/19/2016

MalaCards based summary: Bartter Disease, also known as bartter syndrome, is related to bartter syndrome, type 4b, digenic and bartter syndrome, type 3, and has symptoms including Array, Array and abnormality of metabolism/homeostasis. An important gene associated with Bartter Disease is KCNJ1 (Potassium Voltage-Gated Channel Subfamily J Member 1), and among its related pathways are Hepatic ABC Transporters and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs enalapril and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, adrenal cortex and cortex, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and cardiovascular system.

Genetics Home Reference:25 Bartter syndrome is a group of very similar kidney disorders that cause an imbalance of potassium, sodium, chloride, and related molecules in the body.

Wikipedia:71 Bartter syndrome is a rare inherited defect in the thick ascending limb of the loop of Henle. It is... more...

Related Diseases for Bartter Disease

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Diseases in the Bartter Disease family:

Bartter Syndrome, Type 3 Bartter Syndrome, Type 4a
Bartter Syndrome, Type 2 Bartter Syndrome, Type 1
Bartter Disease Type 5 Bartter Syndrome Type 4

Diseases related to Bartter Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
idRelated DiseaseScoreTop Affiliating Genes
1bartter syndrome, type 4b, digenic32.1CLCNKA, CLCNKB
2bartter syndrome, type 331.7BSND, CLCNKB, KCNJ1, REN, SLC12A1, SLC12A3
3bartter disease type 512.0
4bartter syndrome, type 4a11.5
5bartter syndrome, type 211.5
6bartter syndrome, type 111.5
7fanconi renotubular syndrome 110.8
8congenital chloride diarrhea10.8
9cataract 21, multiple types10.2CLCNKB, REN
10dystonia 2510.2REN, SLC12A3
11microphthalmia, isolated, with coloboma 710.1KCNJ1, REN
12petrositis10.1REN, SLC12A3
13clear cell adenocarcinoma10.0REN, SLC12A3
14brip1-related breast cancer10.0CLCNKA, CLCNKB
15listeria meningitis10.0CASR, REN, SLC12A3
16deafness, autosomal recessive 9610.0CLCNKA, CLCNKB
17deafness, autosomal recessive 3610.0CLCNKA, CLCNKB
18deafness, nonsyndromic, modifier 110.0CASR, CLCN5, KCNJ1
19hypertension, essential10.0REN, SLC12A1, SLC12A3
20pulmonary sarcoidosis10.0KCNJ1, SLC12A3
21high-grade dysplasia in patients with barrett esophagus10.0CASR, CLCN5, REN
22hyperaldosteronism, familial, type iii10.0CASR, KCNJ1, REN, SLC12A1
23impetigo9.9CLCNKB, KCNJ1, MAGED2, SLC12A1
24mixed receptive-expressive language disorder9.9CLCN5, CLCNKB, KCNJ1, SLC12A1
25basal cell carcinoma 49.9CLCNKA, SLC12A1
26maple syrup urine disease, type ii9.9BSND, CLCNKA, CLCNKB
27fatty liver disease9.9CLCNKA, REN, SLC12A1
28renal tubular acidosis9.8
29dysphagia lusoria9.8BSND, KCNJ1, MAGED2, REN, SLC12A1
30aorta angiosarcoma9.7BSND, CLCNKB, KCNJ1, REN, SLC12A1, SLC12A3
31fanconi syndrome9.6
32leptospirosis9.6
33hypokalemia9.6
34indian tick typhus9.6CASR, CLCN5, CLCNKB, KCNJ1, REN, SLC12A3
35hypophosphatemic rickets9.6CLCN5, CLCNKA, CLCNKB, SLC12A1, SLC12A3
36episodic kinesigenic dyskinesia 29.5BSND, CASR, CLCNKB, KCNJ1, REN, SLC12A1
37malignant biphasic mesothelioma9.5BSND, CLCN5, CLCNKB, KCNJ1, REN, SLC12A1
38bipolar disorder8.6BSND, CASR, CLCN5, CLCNKA, CLCNKB, KCNJ1

Graphical network of the top 20 diseases related to Bartter Disease:



Diseases related to bartter disease

Symptoms & Phenotypes for Bartter Disease

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Human phenotypes related to Bartter Disease:

 54 64
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis64 54 Very frequent (99-80%) HP:0001939
2 short stature64 54 Very frequent (99-80%) HP:0004322

GenomeRNAi Phenotypes related to Bartter Disease according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.8SLC12A1, SLC12A2, SLC12A3

MGI Mouse Phenotypes related to Bartter Disease according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.0BSND, KCNJ1, REN, SLC12A1, SLC12A2, SLC12A3
2MP:00053767.7BSND, CASR, CLCN5, CLCNKB, KCNJ1, REN
3MP:00053677.5BSND, CASR, CLCN5, CLCNKB, KCNJ1, REN

Drugs & Therapeutics for Bartter Disease

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Drugs for Bartter Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Pioglitazoneapproved, investigationalPhase 4441111025-46-84829
Synonyms:
(+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+-)-5-((4-(2-(5-ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
(+/-)-5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione
(+/-)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
105355-27-9
111025-46-8
198077-89-3
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-ethyl-2-pyridyl)ethoxy)benzyl)-2,4-thiazolidinedione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]thiazolidine-2,4-dione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
AB1004597
AC-1021
AC1L1J1Q
AD 4833
AD-4833
Actos
Actos (TN)
Actost
BRD-A48430263-003-02-4
BSPBio_002723
C07675
C19H20N2O3S
CHEBI:8228
CHEMBL595
CID4829
D08378
DB01132
Duetact
Glustin
HMS2089H14
HS-0047
 
HSDB 7322
I06-0089
KBio2_002103
KBio2_004671
KBio2_007239
KBio3_001943
KBioGR_001619
KBioSS_002103
LS-151327
MolPort-002-508-211
NCGC00163128-01
NCGC00163128-02
Pioglitazona
Pioglitazona [INN-Spanish]
Pioglitazone
Pioglitazone HCl
Pioglitazone Hydrochloride
Pioglitazone [BAN:INN]
Pioglitazone [Ban:Inn]
Pioglitazone [INN:BAN]
Pioglitazonum
Pioglitazonum [INN-Latin]
SPBio_001897
Spectrum2_001679
Spectrum3_001002
Spectrum4_001130
Spectrum5_001480
Spectrum5_002067
Spectrum_001623
U 72107
U 72107A
U-72107
U72,107A
UNII-X4OV71U42S
Zactos
nchembio790-comp10
pioglitazone (INN)
pioglitazone HCl
2
SpironolactoneapprovedPhase 42321952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
3
Amphotericin Bapproved, investigationalPhase 41211397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
CID1972
 
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
4
Miconazoleapproved, investigational, vet_approvedPhase 4370622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
5HormonesPhase 414415
6Hypoglycemic AgentsPhase 45896
7MineralocorticoidsPhase 4367
8Natriuretic AgentsPhase 41697
9diureticsPhase 41418
10Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 413168
11Hormone AntagonistsPhase 413180
12Diuretics, Potassium SparingPhase 41917
13Mineralocorticoid Receptor AntagonistsPhase 4346
14Tissue Inhibitor of Metalloproteinase-3Phase 43
15insulinPhase 44646
16HIV Protease InhibitorsPhase 45470
172,4-thiazolidinedionePhase 4102
18Liver ExtractsPhase 44067
19Insulin, Globin ZincPhase 44645
20Matrix Metalloproteinase InhibitorsPhase 419
21Tissue Inhibitor of Metalloproteinase-1Phase 411
22TIMP3 protein, humanPhase 43
23TIMP1 protein, humanPhase 411
24
protease inhibitorsPhase 45471
Synonyms:
 
protease inhibitors
25Tissue Inhibitor of MetalloproteinasesPhase 411
26Anti-Infective AgentsPhase 422062
27Liposomal amphotericin BPhase 4121
28Antifungal AgentsPhase 43696
29Anti-Bacterial AgentsPhase 411226
30Antiparasitic AgentsPhase 42199
31Antiprotozoal AgentsPhase 42051
32
Hydrochlorothiazideapproved, vet_approved41358-93-53639
Synonyms:
125727-50-6
3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi
3,4-Dihydrochlorothiazide
58-93-5
6-Chloro-7-sulfamoyl-3, 4-dihy
8049-49-8
AB00052012
AC-11072
AC1L1GDT
AC1Q55FM
AF-614/30832002
AKOS000121373
ARONIS24316
Acesistem
Acuilix
Acuretic
Aldactazide
Aldactazide 25/25
Aldazida
Aldectazide 50/50
Aldoril
Ambap58-93-5
Apo-Hydro
Apresazide
Aquarills
Aquarius
Aquazide H
Aquazide-H
BAS 00371709
BIDD:GT0153
BPBio1_000019
BRD-K13078532-001-05-2
BRN 0625101
BSPBio_000017
BSPBio_002132
Bio-0714
Bremil
Briazide
C7H8ClN3O4S2
CAS-58-93-5
CCRIS 2082
CHEMBL435
CID3639
CPD000035778
Caplaril
Capozide
Carozide
Catiazida
Chlorizide
Chlorosulthiadil
Chlorothiazide
Chlorsulfonamidodihydrobenzothiadiazine dioxide
Chlorzide
Chlothia
Cidrex
Clorana
Component of Butizide Prestabs
Concor Plus
Condiuren
D00340
D006852
DB00999
Diaqua
Dichlorosal
Dichlorotride
Dichlothiazide
Dichlotiazid
Dichlotride
Diclotride
Dicyclotride
Didral
Dihydran
Dihydrochlorothiazid
Dihydrochlorothiazide
Dihydrochlorothiazidum
Dihydrochlorurit
Dihydrochlorurite
Dihydroxychlorothiazidum
Direma
Disalunil
Disothiazid
Diu 25 Vigt
Diu-Melusin
Diu-melusin
Diuril
Diurogen
DivK1c_000289
Dixidrasi
Drenol
Dyazide
EINECS 200-403-3
EU-0100614
Esidrex
Esidrix
Esidrix (TN)
Esimil
Esoidrina
FT-0082750
Fluvin
H 4759
H1274
H2910_SIAL
H4759_SIAL
HCT
HCT-Isis
HCTZ
HCZ
HMS1568A19
HMS1920D19
HMS2091L05
HMS500O11
HMS553N04
HSDB 3096
Hidril
Hidro-Niagrin
Hidrochlortiazid
Hidroclorotiazida
Hidroclorotiazida [INN-Spanish]
Hidroronol
Hidrosaluretil
Hidrotiazida
Hyclosid
Hydrex-semi
Hydril
Hydro Par
Hydro-Aquil
Hydro-D
Hydro-Diuril
Hydro-Saluric
Hydro-T
Hydro-chlor
HydroDIURIL
Hydrochlorat
Hydrochloro Thiazide
Hydrochlorot
Hydrochlorothiazid
Hydrochlorothiazide
Hydrochlorothiazide (JP15/USP/INN)
Hydrochlorothiazide Intensol
Hydrochlorothiazide [INN:BAN:JAN]
 
Hydrochlorothiazidum
Hydrochlorothiazidum [INN-Latin]
Hydrochlorthiazide
Hydrochlorthiazidum
Hydrocot
Hydrodiuretic
Hydrodiuril
Hydropres
Hydrosaluric
Hydrothide
Hydrozide
Hydrozide Injection, Veterinary
Hypothiazid
Hypothiazide
Hytrid
Hyzaar
I09-0531
IDI1_000289
Idroclorotiazide
Idroclorotiazide [DCIT]
Idrotiazide
Inderide
Inderide 80/25
Indroclor
Ivaugan
Jen-Diril
KBio1_000289
KBio2_001357
KBio2_003925
KBio2_006493
KBio3_001352
KBioGR_000351
KBioSS_001357
LS-243
Lopac-H-4759
Lopac0_000614
Lopressor HCT
Lotensin HCT
Lotensin Hct
MLS000069619
Manuril
Maschitt
Maxzide
Maybridge Compound 10
Maybridge1_004336
Mazide 25 mg
Medozide
Megadiuril
Microzide
Microzide (TN)
Mictrin
Mikorten
Modurcen
Moduretic
MolPort-000-144-465
NCGC00015508-01
NCGC00015508-02
NCGC00015508-03
NCGC00015508-07
NCGC00015508-12
NCGC00021906-03
NCGC00021906-04
NCGC00021906-05
NCGC00021906-06
NCGC00021906-07
NCGC00021906-08
NCI-C55925
NCI60_004317
NINDS_000289
NSC 53477
NSC53477
Natrinax
Nefrix
Nefrol
Neo-Codema
Neo-Flumen
Neo-Minzil
Neo-codema
Neoflumen
Newtolide
Novodiurex
Oprea1_357174
Oretic
Pantemon
Panurin
Prestwick0_000009
Prestwick1_000009
Prestwick2_000009
Prestwick3_000009
Prestwick_263
Prinzide
Raunova Plus
Ro-Hydrazide
Ro-hydrazide
Roxane
S1708_Selleck
SAM002554901
SMR000035778
SPBio_001259
SPBio_001938
SPECTRUM1500335
STK315354
Saldiuril
Sectrazide
Selozide
Ser-Ap-Es
Servithiazid
Spectrum2_001040
Spectrum3_000456
Spectrum4_000006
Spectrum5_000824
Spectrum_000877
Spironazide
Su 5879
Tandiur
Thiaretic
Thiuretic
Thlaretic
Timolide
UNII-0J48LPH2TH
Unazid
Unipres
Urodiazin
Urozide
Vaseretic
Vetidrex
WLN: T66 BSWM EM DHJ HG ISZW
ZINC00896569
Ziac
Zide
adiazine-1,1-dioxide
component of Aldactazide
component of Aldoril
component of Caplaril
component of Cyclex
component of Dyazide
component of Esimil
diclot ride
dro-2H-1,2,4-benzothiadiazine 1,1-dioxide
hydrochlorothiazide
panurin dichloride
33Calcium, Dietary5713
34Sodium Chloride Symporter Inhibitors452
35Antihypertensive Agents4207

Interventional clinical trials:

idNameStatusNCT IDPhase
1University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)CompletedNCT00994682Phase 4
2Effect of Pioglitazone on TIMP-3 and TACE in Type 2 DiabetesCompletedNCT01223196Phase 4
3Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin BTerminatedNCT01843309Phase 4
4Parathyroid Hormone (PTH) Homeostasis in Bartter SyndromeUnknown statusNCT01021280
5Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides DiureticsCompletedNCT00276289
6A Translational Approach to Gitelman SyndromeCompletedNCT00822107

Search NIH Clinical Center for Bartter Disease

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: bartter syndrome

Genetic Tests for Bartter Disease

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Genetic tests related to Bartter Disease:

id Genetic test Affiliating Genes
1 Bartter's Syndrome27

Anatomical Context for Bartter Disease

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MalaCards organs/tissues related to Bartter Disease:

36
Kidney, Adrenal cortex, Cortex, Bone

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bartter Disease:
id TissueAnatomical CompartmentCell Relevance
1 KidneyLoop of HenleLoop of Henle Cells Affected by disease

Publications for Bartter Disease

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Articles related to Bartter Disease:

idTitleAuthorsYear
1
Cardiac arrhythmias due to severe hypokalemia in a patient with classic Bartter disease. (15338397)
2004
2
Neonatal Bartter disease diagnosed with the detection of a mutation of the KCNJ1 gene which codifies the synthesis of the renal ROMK1 potassium channel]. (11795013)
2001

Variations for Bartter Disease

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Expression for genes affiliated with Bartter Disease

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Search GEO for disease gene expression data for Bartter Disease.

Pathways for genes affiliated with Bartter Disease

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Pathways related to Bartter Disease according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.8CLCN5, CLCNKA, CLCNKB
2
Show member pathways
8.6CLCN5, SLC12A1, SLC12A2, SLC12A3
3
Show member pathways
8.4BSND, CLCN5, CLCNKA, CLCNKB
47.9BSND, CLCNKA, CLCNKB, KCNJ1, SLC12A1, SLC12A3
5
Show member pathways
7.1BSND, CLCN5, CLCNKA, CLCNKB, SLC12A1, SLC12A2

GO Terms for genes affiliated with Bartter Disease

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Cellular components related to Bartter Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chloride channel complexGO:003470710.2CLCNKA, CLCNKB
2apical plasma membraneGO:00163249.5CASR, SLC12A1, SLC12A2, SLC12A3
3integral component of plasma membraneGO:00058877.8BSND, CASR, CLCN5, CLCNKA, CLCNKB, SLC12A2
4integral component of membraneGO:00160217.2BSND, CASR, CLCN5, CLCNKA, CLCNKB, KCNJ1
5membraneGO:00160206.3BSND, CASR, CLCN5, CLCNKA, CLCNKB, KCNJ1
6plasma membraneGO:00058866.0BSND, CASR, CLCN5, CLCNKA, CLCNKB, KCNJ1

Biological processes related to Bartter Disease according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1potassium ion transportGO:000681310.0KCNJ1, SLC12A1, SLC12A2
2sodium ion transportGO:00068149.9SLC12A1, SLC12A2, SLC12A3
3regulation of ion transmembrane transportGO:00347659.8CLCNKA, CLCNKB, KCNJ1
4excretionGO:00075889.3CLCN5, CLCNKA, CLCNKB, KCNJ1
5regulation of anion transmembrane transportGO:19039599.2BSND, CLCN5, CLCNKA, CLCNKB
6ion transmembrane transportGO:00342208.9BSND, CLCN5, CLCNKA, CLCNKB, SLC12A1
7transmembrane transportGO:00550858.2CLCN5, CLCNKA, CLCNKB, SLC12A1, SLC12A2, SLC12A3
8ion transportGO:00068117.9CLCN5, CLCNKA, CLCNKB, KCNJ1, SLC12A1, SLC12A2
9chloride transmembrane transportGO:19024767.8BSND, CLCN5, CLCNKA, CLCNKB, SLC12A1, SLC12A2
10chloride transportGO:00068217.8BSND, CLCN5, CLCNKA, CLCNKB, SLC12A1, SLC12A2
11transportGO:00068107.2CLCN5, CLCNKA, CLCNKB, KCNJ1, SLC12A1, SLC12A2

Molecular functions related to Bartter Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium:chloride symporter activityGO:000851110.1SLC12A1, SLC12A2
2cation:chloride symporter activityGO:00153779.7SLC12A1, SLC12A2, SLC12A3
3symporter activityGO:00152939.7SLC12A1, SLC12A2, SLC12A3
4voltage-gated ion channel activityGO:00052449.0CLCNKA, CLCNKB, KCNJ1
5chloride channel activityGO:00052549.0BSND, CLCN5, CLCNKA, CLCNKB
6voltage-gated chloride channel activityGO:00052479.0BSND, CLCN5, CLCNKA, CLCNKB

Sources for Bartter Disease

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet