MCID: BSL007
MIFTS: 64

Basal Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Basal Cell Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Basal-cell carcinoma (BCC), a skin cancer, is the most common cancer. It rarely metastasizes or kills.... more...

MalaCards: Basal Cell Carcinoma, also known as basal cell cancer, is related to nevoid basal cell carcinoma syndrome and nodular basal cell carcinoma. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Basal cell carcinoma and Hedgehog Signaling Pathway. The drug fluorouracil and the compounds cyclopamine and 20(s)-hydroxycholesterol have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and breast, and related mouse phenotypes are growth/size and craniofacial.

Aliases & Classifications for Basal Cell Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

basal cell carcinoma 8 10 60
basal cell cancer 8 44 60
malignant basal cell tumor 8 60
basal cell neoplasm 8 60
malignant basal cell neoplasm 8
basal cell carcinoma of skin 8
basal cell carcinoma nos 8
basal cell neoplasm nos 8
epithelioma basal cell 8
carcinoma basal cell 44
basal cell tumor 8
rodent ulcer 8


Related Diseases for Basal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Small Cell Carcinoma Large Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1nevoid basal cell carcinoma syndrome31.9GAS1, SHH, GLI1, ROR2, PTCH2, PTCH1
2nodular basal cell carcinoma31.5KRT31
3squamous cell carcinoma31.4PTCH1, KRT20, MC1R, CYP1A1, GLI1
4medulloblastoma30.9SHH, GLI1, PTCH2, PTCH1, SMO
5xeroderma pigmentosum30.9PTCH1, CYP1A1
6basal cell carcinoma, somatic30.7PTCH1, PTCH2, RASA1
7breast cancer30.6PTCH1, RASA1, MC1R, CYP1A1, GLI1
8basal cell carcinoma, multiple30.6CYP1A1, PTCH1
9pancreatic cancer30.0SHH, GLI1, PTCH1, SMO
10adenocarcinoma30.0PTCH1, KRT20, CYP1A1, GLI1
11superficial basal cell carcinoma11.1
12pigmented basal cell carcinoma10.9
13keratosis10.9
14melanoma10.8
15actinic keratosis10.8
16infiltrative basal cell carcinoma10.7
17follicular basal cell carcinoma10.7
18morpheaform basal cell carcinoma10.7
19seborrheic keratosis10.7
20adenoid basal cell carcinoma10.7
21cystic basal cell carcinoma10.6
22clear cell basal cell carcinoma10.6
23infundibulocystic basal cell carcinoma10.6
24large cell carcinoma10.6
25adenoiditis10.6
26small cell carcinoma10.6
27sebaceous basal cell carcinoma10.6
28sarcomatoid basal cell carcinoma10.5
29scrotum basal cell carcinoma10.5
30skin squamous cell carcinoma10.5
31in situ carcinoma10.5
32keratoacanthoma10.5
33signet ring basal cell carcinoma10.5
34vulva basal cell carcinoma10.5
35metatypical basal cell carcinoma10.5
36micronodular basal cell carcinoma10.5
37prostatitis10.5
38burn scar10.5
39burns10.5
40adenoid cystic carcinoma10.5
41psoriasis10.5
42pleomorphic carcinoma10.4
43syringocystadenoma papilliferum10.4
44meningioma10.4
45bone carcinoma10.4
46brooke-spiegler syndrome10.4
47merkel cell carcinoma10.4
48hypotrichosis10.4
49renal cell carcinoma10.4
50skin melanoma10.4

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Clinical Features for Basal Cell Carcinoma

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Drugs & Therapeutics for Basal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Basal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Search CenterWatch for Basal Cell Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Basal Cell Carcinoma

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Anatomical Context for Basal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Basal Cell Carcinoma:

32
Skin, Prostate, Breast, Lung, Bone, Smooth muscle, T cells, Thyroid, Salivary gland, Eye, Endothelial, Cervix, Testes, Bone marrow, Testis, Uterus, Colon, Lymph node, Brain, Ovary, Trachea

Animal Models for Basal Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Basal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.4SMO, PTCH1, RASA1, MC1R, CYP1A1, GLI1
2MP:000538211.4RASA1, ROR2, SMO, MC1R, SHH, GAS1
3MP:000538511.3CYP1A1, GAS1, SHH, ROR2, RASA1, PTCH2
4MP:000537711.3RASA1, SMO, ROR2, MC1R, SHH, GAS1
5MP:000538111.3PTCH2, RASA1, ROR2, GLI1, SHH, PTCH1
6MP:000538011.1GAS1, SHH, GLI1, ROR2, RASA1, PTCH1
7MP:000537111.0GLI1, ROR2, GAS1
8MP:000538810.9HAS3, SMO, GLI1
9MP:000301210.8SHH, GLI1, CYP1A1, PTCH1, RASA1, MC1R

Publications for Basal Cell Carcinoma

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50PubMed
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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1540)
idTitleAuthorsYear
1
Case of the month. Multiple odontogenic keratocysts in association with nevoid basal cell carcinoma syndrome (NBCCS). (24400412)
2013
2
Photodynamic therapy in the treatment of basal cell carcinoma. (23599819)
2013
3
Basal cell carcinoma in a child with xeroderma pigmentosum: Clinical response with electron beam radiation therapy. (23760329)
2013
4
Emergence of a squamous cell carcinoma phenotype following treatment of metastatic basal cell carcinoma with vismodegib. (23768306)
2013
5
Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma. (24030752)
2013
6
Efficacy of photodynamic therapy for treatment of basal cell carcinoma in organ transplant recipients. (24126943)
2013
7
Gender specific association of child abuse and adult cardiovascular disease in a sample of patients with basal cell carcinoma. (23347911)
2013
8
Study on the effect of blood content on diffuse reflectance spectra of basal cell carcinoma skin tissue. (24023527)
2013
9
Quantification of PpIX concentration in basal cell carcinoma and squamous cell carcinoma models using spatial frequency domain imaging. (23577288)
2013
10
Comment on 'does a history of eczema predict a future Basal cell carcinoma?'. (23340733)
2013
11
Reconstruction of upper eyelid and medial canthus following basal cell carcinoma resection: a successful one-stage repair with three local flaps. (23590377)
2013
12
Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial. (22964973)
2012
13
Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil. (23171011)
2012
14
Retraction: Basal cell nevus syndrome showing several histologic types of basal cell carcinoma. (22577287)
2012
15
Disfiguring basal cell carcinoma of the nose ("clown nose"). (22278876)
2012
16
Nevoid-basal cell carcinoma syndrome: a case report and overview on diagnosis and management. (23139577)
2010
17
CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle. (21225496)
2010
18
Orbital myiasis in a case of invasive basal cell carcinoma. (21234224)
2009
19
Sonic hedgehog signalling inhibits palatogenesis and arrests tooth development in a mouse model of the nevoid basal cell carcinoma syndrome. (19394325)
2009
20
Adenoid cystic/basal cell carcinoma of the prostate. (18295260)
2008
21
Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures. (18679421)
2008
22
Nevoid basal cell carcinoma syndrome (Gorlin syndrome). (19032739)
2008
23
Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous squamous cell carcinoma, Bowen's disease and basal cell carcinoma. (18547788)
2008
24
A randomized study of minimal curettage followed by topical photodynamic therapy compared with surgical excision for low-risk nodular basal cell carcinoma. (17573890)
2007
25
Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. (17593083)
2007
26
Efficacy of photodynamic therapy with methyl aminolevulinate in the treatment of superficial and nodular basal cell carcinoma: an open-label trial. (17673385)
2007
27
CD-10 immunostaining differentiates superficial basal cell carcinoma from cutaneous squamous cell carcinoma. (18032951)
2007
28
Topical therapy in the treatment of actinic keratosis and basal cell carcinoma. (17508492)
2007
29
Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells. (17295236)
2007
30
Basal cell carcinoma arising within port-wine stain in Klippel-Trenaunay syndrome. (17894722)
2007
31
Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1. (16426388)
2006
32
The lysyl oxidase LOX is absent in basal and squamous cell carcinomas and its knockdown induces an invading phenotype in a skin equivalent model. (16533769)
2006
33
Pilot study of imiquimod 5% cream as adjunctive therapy to curettage and electrodesiccation for nodular basal cell carcinoma. (16393600)
2006
34
Invade or proliferate? Two contrasting events in malignant behavior governed by p16(INK4a) and an intact Rb pathway illustrated by a model system of basal cell carcinoma. (12702553)
2003
35
Nevoid basal cell carcinoma syndrome associated with lymphomatoid papulosis. (12835561)
2003
36
Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma. (12165851)
2002
37
Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. (10504535)
1999
38
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. (9931336)
1999
39
Expression of bcl-2, bax and p53 protein in the basal cell carcinoma]. (11938785)
1999
40
Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells. (9764849)
1998
41
Transforming growth factor-beta 3 is expressed in nondividing basal epithelial cells in normal human prostate and benign prostatic hyperplasia, and is no longer detectable in prostate carcinoma. (9140123)
1997
42
Altered expression of the hemidesmosome-anchoring filament complex proteins in basal cell carcinoma: possible role in the origin of peritumoral lacunae. (9039292)
1997
43
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. (8782823)
1996
44
Epidermal fatty-acid-binding protein in psoriasis, basal and squamous cell carcinomas: an immunohistological study. (8726632)
1996
45
Epiligrin is decreased in papulonodular basal cell carcinoma tumor nest basement membranes and the extracellular matrix of transformed human epithelial cells. (7551559)
1995
46
Culture of basal cell carcinoma. (1370231)
1992
47
Primary endophytic nodular basal cell carcinoma. (7094630)
1982
48
The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. (6177160)
1981
49
Recurrence of the odontogenic keratocyst in 13 patients with the nevoid basal cell carcinoma syndrome. A 6-year follow-up. (6777316)
1980
50
Linkage analysis of the nevoid basal cell carcinoma syndrome. (5715624)
1968

Genetic Variations for Basal Cell Carcinoma

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Expression for genes affiliated with Basal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Basal Cell Carcinoma

Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

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29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2GLI1, GAS1, SHH, MC1R, PTCH2, PTCH1
2
Hide members
11.0PTCH1, GAS1, SHH, GLI1, PTCH2
311.0SMO, SHH, GLI1, PTCH2, PTCH1
411.0PTCH2, SHH, GAS1, PTCH1, SMO
510.9SHH, GLI1, PTCH1, PTCH2
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.9GLI1, PTCH1, SMO, SHH
710.9SMO, PTCH1, GLI1, SHH
810.7PTCH1, SHH

Compounds for genes affiliated with Basal Cell Carcinoma

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44Novoseek, 59Tocris Bioscience
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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 5912.0SMO, PTCH1, GLI1, SHH
220(s)-hydroxycholesterol5910.7GLI1, SHH
3ay 9944 dihydrochloride5910.7SHH, GLI1
4ciliobrevin a5910.6SHH, GLI1
5sant-15910.4SHH, GLI1

GO Terms for genes affiliated with Basal Cell Carcinoma

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16Gene Ontology
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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:07237210.8SMO, PTCH1, GLI1

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smoothened signaling pathwayGO:04588011.3GAS1, SMO, GLI1, SHH
2smoothened signaling pathwayGO:00722411.3SHH, GLI1, PTCH1, SMO
3smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193811.2GLI1, SMO, SHH
4somite developmentGO:06105311.2SMO, PTCH1, SHH
5renal system developmentGO:07200111.2SMO, PTCH1, SHH
6dorsal/ventral neural tube patterningGO:02190411.1SHH, GAS1, SMO
7regulation of smoothened signaling pathwayGO:00858911.1PTCH1, GLI1, GAS1
8negative regulation of smoothened signaling pathwayGO:04587911.1PTCH1, GAS1, PTCH2
9dorsal/ventral pattern formationGO:00995311.1SHH, PTCH1, GLI1
10camera-type eye developmentGO:04301011.1GAS1, SHH, CYP1A1
11vasculogenesisGO:00157011.1SMO, RASA1, SHH
12epidermis developmentGO:00854411.1PTCH1, PTCH2, KRT31
13negative regulation of canonical Wnt receptor signaling pathwayGO:09009011.0ROR2, GLI1, SHH
14determination of left/right asymmetry in lateral mesodermGO:00314011.0SHH, SMO
15positive regulation of hh target transcription factor activityGO:00722811.0SHH, SMO
16ventral midline developmentGO:00741811.0GLI1, SHH
17cerebellar cortex morphogenesisGO:02169611.0GLI1, SMO
18intermediate filament organizationGO:04510910.9SHH, KRT20
19cellular response to cholesterolGO:07139710.9PTCH1, SMO
20thalamus developmentGO:02179410.9SHH, SMO
21mammary gland epithelial cell differentiationGO:06064410.8PTCH1, SMO
22positive regulation of protein import into nucleusGO:04230710.8SMO, SHH
23spinal cord motor neuron differentiationGO:02152210.8PTCH1, SHH
24cell fate specificationGO:00170810.7SMO, SHH
25protein localization to nucleusGO:03450410.7SHH, SMO
26positive regulation of neuroblast proliferationGO:00205210.6SHH, SMO
27neuron fate commitmentGO:04866310.4SMO, SHH

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.8SMO, PTCH1, SHH
2hedgehog receptor activityGO:00815810.7PTCH1, PTCH2
3smoothened bindingGO:00511910.6PTCH1, PTCH2
4hedgehog family protein bindingGO:09710810.4PTCH1, PTCH2

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet