MCID: BSL007
MIFTS: 67

Basal Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories
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Summaries for Basal Cell Carcinoma

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Wikipedia:65 Basal-cell carcinoma or basal cell cancer (BCC), a skin cancer, is the most common cancer.[dead link] It... more...

MalaCards based summary: Basal Cell Carcinoma, also known as basal cell cancer, is related to nodular basal cell carcinoma and nevoid basal cell carcinoma syndrome. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Glypican 3 network and Aurora A signaling. The drug fluorouracil and the compounds 20(s)-hydroxycholesterol and ciliobrevin a have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and bone, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:8 A skin carcinoma affecting basal cells.

Aliases & Classifications for Basal Cell Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Basal Cell Carcinoma, Aliases & Descriptions:

Name: Basal Cell Carcinoma 8 10 62
Basal Cell Cancer 8 44 62
Malignant Basal Cell Neoplasm 8 62
Basal Cell Carcinoma of Skin 8 62
Malignant Basal Cell Tumor 8 62
Epithelioma Basal Cell 8 62
 
Basal Cell Neoplasm 8 62
Basal Cell Carcinoma Nos 8
Basal Cell Neoplasm Nos 8
Carcinoma Basal Cell 44
Basal Cell Tumor 8
Rodent Ulcer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


Related Diseases for Basal Cell Carcinoma

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Diseases in the Basal Cell Carcinoma family:

Large Cell Carcinoma Small Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1nodular basal cell carcinoma31.5KRT38, KRT31
2nevoid basal cell carcinoma syndrome31.2OR10X1, ROR2, GAS1, PTCH1, PTCH2, SHH
3basal cell carcinoma, multiple31.1CYP1A1, PTCH1
4basal cell carcinoma, somatic31.1RASA1, PTCH2, PTCH1
5xeroderma pigmentosum31.0TP53, CYP1A1, PTCH1
6ameloblastoma30.9PTCH1, GLI1
7medulloblastoma30.8PTCH1, PTCH2, SHH, SMO, TP53, GLI1
8pancreatic cancer30.0SMO, GLI1, TP53, SHH, PTCH1
9superficial basal cell carcinoma11.1
10pigmented basal cell carcinoma11.0
11keratosis10.9
12melanoma10.9
13actinic keratosis10.8
14infiltrative basal cell carcinoma10.7
15infundibulocystic basal cell carcinoma10.7
16seborrheic keratosis10.7
17morpheaform basal cell carcinoma10.7
18cystic basal cell carcinoma10.7
19adenoiditis10.6
20clear cell basal cell carcinoma10.6
21adenoid basal cell carcinoma10.6
22metatypical basal cell carcinoma10.6
23sarcomatoid basal cell carcinoma10.6
24micronodular basal cell carcinoma10.6
25keratoacanthoma10.6
26prostatitis10.5
27burn scar10.5
28burns10.5
29psoriasis10.5
30basaloid follicular hamartoma10.5
31semilobar holoprosencephaly10.5SHH
32single median maxillary central incisor10.5SHH
33syringocystadenoma papilliferum10.5
34breast cancer10.5
35meningioma10.5
36bazex-dupre-christol syndrome10.5
37lobar holoprosencephaly10.5PTCH1
38fibroma10.4
39vulva basal cell carcinoma10.4
40brooke-spiegler syndrome10.4
41anal margin basal cell carcinoma10.4
42external ear basal cell carcinoma10.4
43scrotum basal cell carcinoma10.4
44merkel cell carcinoma10.4
45hypotrichosis10.4
46rombo syndrome10.4
47cutaneous malignant melanoma10.4
48vitiligo10.4
49myelophthisic anemia10.4
50signet ring basal cell carcinoma10.4

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Symptoms for Basal Cell Carcinoma

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Drugs & Therapeutics for Basal Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Basal Cell Carcinoma

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Anatomical Context for Basal Cell Carcinoma

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MalaCards organs/tissues related to Basal Cell Carcinoma:

32
Skin, Prostate, Bone, Breast, Smooth muscle, Lung, T cells, Eye, Bone marrow, Thyroid, Testes, Endothelial, Lymph node, Brain, Heart, Salivary gland, Ovary, Uterus, Testis, Cervix, Trachea

Animal Models for Basal Cell Carcinoma or affiliated genes

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Publications for Basal Cell Carcinoma

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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1517)
idTitleAuthorsYear
1
Invasive basal cell carcinoma in a xeroderma pigmentosum patient: facing secondary and tertiary aggressive recurrences. (24978686)
2014
2
Narrow-margin excision is a safe, reliable treatment for well-defined, primary pigmented basal cell carcinoma: an analysis of 288 lesions in Japan. (25186070)
2014
3
Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma. (25353070)
2014
4
Case of the month. Multiple odontogenic keratocysts in association with nevoid basal cell carcinoma syndrome (NBCCS). (24400412)
2013
5
Basal cell carcinoma margin delineation: is curettage useful? A surgical and histological study. (23216407)
2013
6
Regional variations of basal cell carcinoma incidence in the U.K. using The Health Improvement Network database (2004-10). (23701520)
2013
7
Pigmented Basal cell carcinoma: a clinical variant, report of two cases. (24551712)
2013
8
Mushroom-Like Giant Basal Cell Carcinoma on the Nasal Tip. (24372940)
2013
9
Clinical and radiological features in young individuals with nevoid basal cell carcinoma syndrome. (22918513)
2013
10
Epidemiology of basal cell carcinoma in Lithuania, 1996-2010. (23795568)
2013
11
Vismodegib (Erivedge) for basal cell carcinoma. (22777303)
2012
12
Splicing aberration in naevoid basal cell carcinoma syndrome. (22434048)
2012
13
Basal cell carcinoma of the scrotum with a lesion of 51 years' duration. (22171695)
2012
14
Risk factors for orbital exenteration in periocular basal cell carcinoma. (22709845)
2012
15
Adamantinoid basal cell carcinoma: a predictor of more-aggressive clinical behavior. (22551358)
2012
16
Treatment of nodular basal cell carcinoma with cryotherapy and reduced protocol of imiquimod. (23270198)
2012
17
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. (21430703)
2011
18
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
19
GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma. (21577203)
2011
20
Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream. (18789101)
2008
21
Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (18789069)
2008
22
Mutations of microsatellite instability target genes in sporadic basal cell carcinomas. (17950544)
2007
23
Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. (17638732)
2007
24
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
25
Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma. (17875873)
2007
26
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. (16582078)
2006
27
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
28
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
29
Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma. (12692363)
2003
30
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
31
Shadow cell basal cell carcinoma with acantholysis. (11829183)
2002
32
Sub-populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation. (11168750)
2001
33
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. (11174390)
2001
34
Activation of expression of hedgehog target genes in basal cell carcinomas. (11348463)
2001
35
Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome. (11457640)
2001
36
Low levels of urokinase plasminogen activator components in basal cell carcinoma of the skin. (10699914)
2000
37
Basal cell carcinoma with tumor epithelial and stromal giant cells: a variant of pleomorphic basal cell carcinoma. (10535579)
1999
38
Immunohistochemical characterization of pleomorphic giant cells in basal cell carcinoma. (10487292)
1999
39
Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. (9256917)
1997
40
Molecular basis of the nevoid basal cell carcinoma syndrome. (9425597)
1997
41
bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. (8043419)
1994
42
Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection. (7962742)
1994
43
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
44
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma. (1342967)
1992
45
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. (1469302)
1992
46
Possibilities for application of radioimmunological analysis of CEA, AFP, SP1 and ferritin in patients with basal cell carcinoma of the eyelids. (1726640)
1991
47
Severe irritant dermatitis mimicking a basal cell carcinoma. (6230178)
1983
48
The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. (6177160)
1981
49
Pigmented basal-cell carcinoma in verrucous nevi. Report of 2 cases. (13785794)
1961
50
Superficial Basal-cell Carcinoma. (19992640)
1943

Variations for Basal Cell Carcinoma

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Expression for genes affiliated with Basal Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Basal Cell Carcinoma

Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

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Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PTCH1, SHH
210.0TP53, RASA1
39.6SHH, PTCH2, PTCH1, GLI1
49.5TP53, SHH, SMO
59.5TP53, PTCH1, SMO
6
Show member pathways
9.3SMO, SHH, PTCH2, PTCH1
79.3SMO, SHH, PTCH1, GLI1
89.3GLI1, PTCH1, SHH, SMO
9
Show member pathways
9.2GAS1, ROR2, PTCH2, SMO
109.1SMO, SHH, PTCH2, PTCH1, GAS1
11
Show member pathways
8.9GAS1, GLI1, PTCH1, PTCH2, SHH, SMO
128.9SMO, SHH, PTCH2, PTCH1, TP53, GLI1
13
Show member pathways
8.7SMO, PTCH2, TP53, ROR2, RASA1, GAS1
14
Show member pathways
8.6SMO, SHH, PTCH2, PTCH1, TP53, GLI1
15
Show member pathways
8.2SMO, SHH, PTCH2, PTCH1, TP53, OR10X1

Compounds for genes affiliated with Basal Cell Carcinoma

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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
120(s)-hydroxycholesterol6110.2SHH, GLI1
2ciliobrevin a6110.2SHH, GLI1
3sant-16110.2SHH, GLI1
4ay 9944 dihydrochloride6110.1SHH, GLI1
5ellipticine4410.0TP53, CYP1A1
6bpde4410.0TP53, CYP1A1
73,3-diindolylmethane449.9TP53, CYP1A1
8aristolochic acid44 210.7TP53, CYP1A1
9cyclopamine44 6110.5GLI1, PTCH1, SHH, SMO

GO Terms for genes affiliated with Basal Cell Carcinoma

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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:0723729.5GLI1, PTCH1, SMO

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1ventral midline developmentGO:00741810.4SHH, GLI1
2spinal cord motor neuron differentiationGO:02152210.3SHH, PTCH1
3dorsal/ventral pattern formationGO:00995310.2SHH, PTCH1, GLI1
4negative regulation of smoothened signaling pathwayGO:04587910.2GAS1, PTCH1, PTCH2
5regulation of smoothened signaling pathwayGO:00858910.2PTCH1, GLI1, GAS1
6camera-type eye developmentGO:04301010.2GAS1, SHH, CYP1A1
7negative regulation of canonical Wnt signaling pathwayGO:09009010.1GLI1, ROR2, SHH
8positive regulation of hh target transcription factor activityGO:00722810.1SMO, SHH
9determination of left/right asymmetry in lateral mesodermGO:00314010.1SMO, SHH
10response to antibioticGO:04667710.1CYP1A1, TP53
11cerebellar cortex morphogenesisGO:02169610.1GLI1, SMO
12epidermis developmentGO:00854410.1PTCH2, PTCH1, KRT31
13thalamus developmentGO:02179410.1SMO, SHH
14mammary gland epithelial cell differentiationGO:06064410.1SMO, PTCH1
15cellular response to cholesterolGO:07139710.0PTCH1, SMO
16positive regulation of protein import into nucleusGO:04230710.0SHH, SMO
17cell fate specificationGO:00170810.0SMO, SHH
18neuron fate commitmentGO:04866310.0SMO, SHH
19T cell differentiation in thymusGO:03307710.0TP53, SHH
20positive regulation of neuroblast proliferationGO:00205210.0SMO, SHH
21embryonic digestive tract morphogenesisGO:04855710.0SHH, SMO
22smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193810.0GLI1, SHH, SMO
23protein localization to nucleusGO:0345049.9SHH, SMO
24somite developmentGO:0610539.9PTCH1, SHH, SMO
25somitogenesisGO:0017569.9ROR2, TP53
26renal system developmentGO:0720019.9SMO, SHH, PTCH1
27hair follicle morphogenesisGO:0310699.9SHH, SMO
28dorsal/ventral neural tube patterningGO:0219049.9GAS1, SHH, SMO
29vasculogenesisGO:0015709.9RASA1, SHH, SMO
30heart morphogenesisGO:0030079.8SMO, PTCH1
31positive regulation of transcription, DNA-templatedGO:0458939.7SHH, TP53, ROR2, GLI1
32smoothened signaling pathwayGO:0072249.7SMO, SHH, PTCH1, GLI1
33positive regulation of smoothened signaling pathwayGO:0458809.7GAS1, GLI1, SHH, SMO
34positive regulation of mesenchymal cell proliferationGO:0020539.6SMO, GAS1
35neural crest cell migrationGO:0017559.4SHH, SMO
36negative regulation of transcription from RNA polymerase II promoterGO:0001229.3SMO, SHH, PTCH1, TP53

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hedgehog family protein bindingGO:09710810.1PTCH1, PTCH2
2smoothened bindingGO:00511910.0PTCH2, PTCH1
3hedgehog receptor activityGO:0081589.8PTCH2, PTCH1
4Wnt-protein bindingGO:0171479.7ROR2, SMO
5patched bindingGO:0051139.6PTCH1, SHH, SMO

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet