MCID: BSL007
MIFTS: 62

Basal Cell Carcinoma malady

Skin, Cancer categories

Summaries for Basal Cell Carcinoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Basal-cell carcinoma (BCC), a skin cancer, is the most common cancer. It rarely metastasizes or kills.... more...

MalaCards: Basal Cell Carcinoma, also known as basal cell cancer, is related to nevoid basal cell carcinoma syndrome and basal cell carcinoma, multiple. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Basal cell carcinoma and Hedgehog Signaling Pathway. The drug fluorouracil and the compounds cyclopamine and 20(s)-hydroxycholesterol have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and brain, and related mouse phenotypes are growth/size and craniofacial.

Aliases & Classifications for Basal Cell Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin


Aliases & Descriptions:

basal cell carcinoma 8 10 61
basal cell cancer 8 45 61
malignant basal cell tumor 8 61
basal cell neoplasm 8 61
malignant basal cell neoplasm 8
basal cell carcinoma of skin 8
basal cell carcinoma nos 8
basal cell neoplasm nos 8
epithelioma basal cell 8
carcinoma basal cell 45
basal cell tumor 8
rodent ulcer 8


Related Diseases for Basal Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1nevoid basal cell carcinoma syndrome32.0ROR2, SMO, PTCH1, PTCH2, GLI1, SHH
2basal cell carcinoma, multiple31.5CYP1A1, PTCH1
3nodular basal cell carcinoma31.5KRT31
4squamous cell carcinoma31.4GLI1, CYP1A1, MC1R, KRT20, PTCH1
5xeroderma pigmentosum30.9PTCH1, CYP1A1
6basal cell carcinoma, somatic30.8RASA1, PTCH2, PTCH1
7adenocarcinoma30.1KRT20, CYP1A1, GLI1, PTCH1
8n syndrome11.3
9nevo syndrome11.3
10superficial basal cell carcinoma11.1
11pigmented basal cell carcinoma10.9
12eye carcinoma10.8
13eyelid carcinoma10.8
14actinic keratosis10.8
15follicular basal cell carcinoma10.7
16morpheaform basal cell carcinoma10.7
17clear cell basal cell carcinoma10.7
18adenoid basal cell carcinoma10.7
19infiltrative basal cell carcinoma10.7
20cystic basal cell carcinoma10.7
21infundibulocystic basal cell carcinoma10.6
22large cell carcinoma10.6
23small cell carcinoma10.6
24sebaceous basal cell carcinoma10.6
25basal cell carcinoma 110.6
26sarcomatoid basal cell carcinoma10.6
27vulva basal cell carcinoma10.6
28scrotum basal cell carcinoma10.6
29skin squamous cell carcinoma10.6
30signet ring basal cell carcinoma10.5
31metatypical basal cell carcinoma10.5
32micronodular basal cell carcinoma10.5
33burn scar10.5
34adenoid cystic carcinoma10.5
35basaloid follicular hamartoma10.5
36basal cell carcinoma 210.5
37pleomorphic carcinoma10.4
38syringocystadenoma papilliferum10.4
39bone carcinoma10.4
40brooke-spiegler syndrome10.4
41merkel cell carcinoma10.4
42anal squamous cell carcinoma10.4
43micro syndrome10.4
44bazex-dupre-christol syndrome10.4
45rombo syndrome10.4
46cutaneous malignant melanoma10.4
47myelophthisic anemia10.4
48spindle cell carcinoma10.4
49anal margin basal cell carcinoma10.4
50external ear basal cell carcinoma10.4

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Clinical Features for Basal Cell Carcinoma

Drugs & Therapeutics for Basal Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Basal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Search CenterWatch for Basal Cell Carcinoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Basal Cell Carcinoma

Anatomical Context for Basal Cell Carcinoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Basal Cell Carcinoma:

33
Skin, Ovary, Brain, Lymph node, Lung, Uterus, Bone marrow, Whole blood, Smooth muscle, Skeletal muscle, Colon, Thyroid, Salivary gland, Breast, Prostate, Testis, Cervix, Tonsil, T cells, B cells, Endothelial, Fetal brain, Fetal lung, Trachea, Fetal thyroid, Testis germ

Animal Models for Basal Cell Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Basal Cell Carcinoma

Sources:
51PubMed
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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
Expanded access study of patients with advanced basalA cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib. (24189279)
2014
2
Regional variations of basal cell carcinoma incidence in the U.K. using The Health Improvement Network database (2004-10). (23701520)
2013
3
Mechanisms and efficacy of vismodegib in the treatment of basal cell carcinoma. (24229739)
2013
4
Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate. (23725586)
2013
5
Clinical manifestations and treatment for keratocystic odontogenic tumors associated with nevoid basal cell carcinoma syndrome: a study in 25 Japanese patients. (22882291)
2013
6
High-resolution imaging of basal cell carcinoma: a comparison between multiphoton microscopy with fluorescence lifetime imaging and reflectance confocal microscopy. (22970856)
2013
7
Nodular Basal cell carcinoma successfully treated with intralesional 5-aminolevulinic Acid injection-photodynamic therapy. (23197924)
2012
8
Basal cell carcinoma arising in a bacille Calmette-GuAcrin vaccination scar. (22530332)
2012
9
Submental transposition flap for a large defect after excision of a recurrent basal cell carcinoma on the chin. (23107332)
2012
10
Aggressive basal cell carcinoma: dermatoscopy vascular features as clues to the diagnosis. (23785604)
2012
11
Heterozygous tandem duplication within the PTCH1 gene results in nevoid basal cell carcinoma syndrome. (22711650)
2012
12
Mediastinal fetal rhabdomyoma in nevoid basal cell carcinoma syndrome: a case report and review of the literature. (21710240)
2011
13
Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature. (22529579)
2011
14
A Case of Cystic Basal Cell Carcinoma Which Shows a Homogenous Blue/Black Area under Dermatoscopy. (21151522)
2011
15
Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissues. (19885561)
2009
16
Low-grade fibromatosis-like spindle cell metaplastic carcinoma: a basal-like tumor with a favorable clinical outcome. Report of two cases. (19579879)
2009
17
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. (19738459)
2009
18
Obligate basal cell component in salivary oncocytoma facilitates distinction from acinic cell carcinoma. (19646823)
2009
19
Enhancement of methyl-aminolevulinate photodynamic therapy by iron chelation with CP94: an in vitro investigation and clinical dose-escalating safety study for the treatment of nodular basal cell carcinoma. (18239941)
2008
20
Basaloid squamous cell carcinoma of the external auditory canal: case report. (17235532)
2007
21
Radial streaking: unusual dermoscopic pattern in pigmented superficial basal cell carcinoma. (17894724)
2007
22
Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate. (16374471)
2006
23
A case of penile superficial basal cell carcinoma involving the inner surface of foreskin. (16303075)
2005
24
Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis. (15377354)
2004
25
Basaloid squamous cell carcinoma report of a case and review of literature. (15164662)
2003
26
p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. (12538474)
2003
27
Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma. (12823438)
2003
28
Superficial radiotherapy for patients with basal cell carcinoma: recurrence rates, histologic subtypes, and expression of p53 and Bcl-2. (14669293)
2003
29
Medulloblastoma with extensive nodularity in nevoid basal cell carcinoma syndrome. (12555262)
2003
30
Nevoid basal cell carcinoma syndrome in an African American woman. (12041818)
2002
31
A case of basal cell carcinoma arising in epidermal nevus. (12492992)
2002
32
Nitric oxide and endothelin-1,2 in actinic keratosis and basal cell carcinoma: changes in nitric oxide/endothelin ratio. (11737437)
2001
33
E-cadherin expression is frequently reduced in infiltrative basal cell carcinoma. (11211800)
2000
34
Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma. (10504535)
1999
35
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene in basal cell carcinoma and medulloblastoma on chromosome 1p32. (9931336)
1999
36
Expression of bcl-2, bax and p53 protein in the basal cell carcinoma]. (11938785)
1999
37
Metastatic laryngeal basaloid squamous cell carcinoma simulating primary small cell carcinoma of the lung on fine needle aspiration lung biopsy. A case report. (9622708)
1998
38
Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. (9256917)
1997
39
Photodynamic therapy of superficial basal cell carcinoma by instillation of aminolevulinic acid and irradiation with visible light. (9420532)
1997
40
No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. (9140104)
1997
41
The expression of c-erbB-1 and c-erbB-2 oncogenes in basal cell carcinoma and squamous cell carcinoma of skin. (9387420)
1996
42
Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection. (7962742)
1994
43
Giant adenoid basal cell carcinoma. (8060083)
1994
44
Fine genetic mapping of the gene for nevoid basal cell carcinoma syndrome. (8001963)
1994
45
Nevoid Basal Cell Carcinoma Syndrome (20301330)
1993
46
Comparison of proteinase activities in squamous cell carcinoma, basal cell epithelioma, and seborrheic keratosis. (3286780)
1988
47
Subungual basal cell carcinoma versus acral lentiginous melanoma. (3655030)
1987
48
Nevoid basal cell carcinoma syndrome: bilateral ovarian fibromas in a 3 1/2-year-old girl. (3950141)
1986
49
Multiple nevoid basal cell carcinoma syndrome and Hodgkin's disease. (6722731)
1984
50
Nevoid basal cell carcinoma syndrome: report of case. (4507243)
1972

Genetic Variations for Basal Cell Carcinoma

Expression for genes affiliated with Basal Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Basal Cell Carcinoma

Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

Sources:
30KEGG, 38NCBI BioSystems Database, 60Tocris Bioscience, 4Cell Signaling Technology, 12EMD Millipore
See all sources

Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2GLI1, GAS1, SHH, MC1R, PTCH2, PTCH1
2
Hide members
11.0PTCH1, GAS1, SHH, GLI1, PTCH2
311.0SMO, SHH, GLI1, PTCH2, PTCH1
411.0PTCH2, SHH, GAS1, PTCH1, SMO
510.9SHH, GLI1, PTCH1, PTCH2
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.9GLI1, PTCH1, SMO, SHH
710.9SMO, PTCH1, GLI1, SHH
810.7PTCH1, SHH

Compounds for genes affiliated with Basal Cell Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience
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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine45 6012.0SMO, PTCH1, GLI1, SHH
220(s)-hydroxycholesterol6010.7SHH, GLI1
3ay 9944 dihydrochloride6010.7GLI1, SHH
4ciliobrevin a6010.6SHH, GLI1
5sant-16010.4SHH, GLI1

GO Terms for genes affiliated with Basal Cell Carcinoma

Sources:
16Gene Ontology
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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:07237210.8SMO, PTCH1, GLI1

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smoothened signaling pathwayGO:04588011.3SMO, GLI1, SHH, GAS1
2smoothened signaling pathwayGO:00722411.3SMO, PTCH1, GLI1, SHH
3smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193811.2SMO, GLI1, SHH
4somite developmentGO:06105311.2SHH, PTCH1, SMO
5renal system developmentGO:07200111.2SHH, PTCH1, SMO
6dorsal/ventral neural tube patterningGO:02190411.1SMO, SHH, GAS1
7regulation of smoothened signaling pathwayGO:00858911.1PTCH1, GLI1, GAS1
8negative regulation of smoothened signaling pathwayGO:04587911.1GAS1, PTCH2, PTCH1
9dorsal/ventral pattern formationGO:00995311.1PTCH1, GLI1, SHH
10camera-type eye developmentGO:04301011.1CYP1A1, SHH, GAS1
11vasculogenesisGO:00157011.1SHH, RASA1, SMO
12epidermis developmentGO:00854411.1PTCH1, PTCH2, KRT31
13negative regulation of canonical Wnt receptor signaling pathwayGO:09009011.0ROR2, GLI1, SHH
14ventral midline developmentGO:00741811.0SHH, GLI1
15positive regulation of hh target transcription factor activityGO:00722811.0SHH, SMO
16determination of left/right asymmetry in lateral mesodermGO:00314011.0SHH, SMO
17cerebellar cortex morphogenesisGO:02169611.0SMO, GLI1
18cellular response to cholesterolGO:07139710.9PTCH1, SMO
19intermediate filament organizationGO:04510910.9SHH, KRT20
20mammary gland epithelial cell differentiationGO:06064410.9PTCH1, SMO
21thalamus developmentGO:02179410.8SHH, SMO
22positive regulation of protein import into nucleusGO:04230710.8SMO, SHH
23spinal cord motor neuron differentiationGO:02152210.8SHH, PTCH1
24cell fate specificationGO:00170810.7SHH, SMO
25protein localization to nucleusGO:03450410.7SMO, SHH
26positive regulation of neuroblast proliferationGO:00205210.6SMO, SHH
27neuron fate commitmentGO:04866310.4SMO, SHH

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.8SMO, PTCH1, SHH
2hedgehog receptor activityGO:00815810.7PTCH1, PTCH2
3smoothened bindingGO:00511910.6PTCH1, PTCH2
4hedgehog family protein bindingGO:09710810.4PTCH1, PTCH2

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet