MCID: BSL007
MIFTS: 64

Basal Cell Carcinoma malady

Skin diseases, Cancer diseases categories

Summaries for Basal Cell Carcinoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Basal-cell carcinoma (BCC), a skin cancer, is the most common cancer. It rarely metastasizes or kills.... more...

MalaCards: Basal Cell Carcinoma, also known as basal cell cancer, is related to nevoid basal cell carcinoma syndrome and nodular basal cell carcinoma. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Basal cell carcinoma and Hedgehog Signaling Pathway. The drug fluorouracil and the compounds cyclopamine and 20(s)-hydroxycholesterol have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and breast, and related mouse phenotypes are growth/size and craniofacial.

Aliases & Classifications for Basal Cell Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases


Aliases & Descriptions:

basal cell carcinoma 8 10 60
basal cell cancer 8 44 60
malignant basal cell tumor 8 60
basal cell neoplasm 8 60
malignant basal cell neoplasm 8
basal cell carcinoma of skin 8
basal cell carcinoma nos 8
basal cell neoplasm nos 8
epithelioma basal cell 8
carcinoma basal cell 44
basal cell tumor 8
rodent ulcer 8


Related Diseases for Basal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Small Cell Carcinoma Large Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1nevoid basal cell carcinoma syndrome31.9GAS1, SHH, GLI1, ROR2, PTCH2, PTCH1
2nodular basal cell carcinoma31.5KRT31
3squamous cell carcinoma31.4PTCH1, KRT20, MC1R, CYP1A1, GLI1
4medulloblastoma30.9SHH, GLI1, PTCH2, PTCH1, SMO
5xeroderma pigmentosum30.9PTCH1, CYP1A1
6basal cell carcinoma, somatic30.7PTCH1, PTCH2, RASA1
7breast cancer30.6PTCH1, RASA1, MC1R, CYP1A1, GLI1
8basal cell carcinoma, multiple30.6CYP1A1, PTCH1
9pancreatic cancer30.0SHH, GLI1, PTCH1, SMO
10adenocarcinoma30.0PTCH1, KRT20, CYP1A1, GLI1
11superficial basal cell carcinoma11.1
12pigmented basal cell carcinoma10.9
13keratosis10.9
14melanoma10.8
15actinic keratosis10.8
16infiltrative basal cell carcinoma10.7
17follicular basal cell carcinoma10.7
18morpheaform basal cell carcinoma10.7
19seborrheic keratosis10.7
20adenoid basal cell carcinoma10.7
21cystic basal cell carcinoma10.6
22clear cell basal cell carcinoma10.6
23infundibulocystic basal cell carcinoma10.6
24large cell carcinoma10.6
25adenoiditis10.6
26small cell carcinoma10.6
27sebaceous basal cell carcinoma10.6
28sarcomatoid basal cell carcinoma10.5
29scrotum basal cell carcinoma10.5
30skin squamous cell carcinoma10.5
31in situ carcinoma10.5
32keratoacanthoma10.5
33signet ring basal cell carcinoma10.5
34vulva basal cell carcinoma10.5
35metatypical basal cell carcinoma10.5
36micronodular basal cell carcinoma10.5
37prostatitis10.5
38burn scar10.5
39burns10.5
40adenoid cystic carcinoma10.5
41psoriasis10.5
42pleomorphic carcinoma10.4
43syringocystadenoma papilliferum10.4
44meningioma10.4
45bone carcinoma10.4
46brooke-spiegler syndrome10.4
47merkel cell carcinoma10.4
48hypotrichosis10.4
49renal cell carcinoma10.4
50skin melanoma10.4

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Clinical Features for Basal Cell Carcinoma

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Drugs & Therapeutics for Basal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Basal Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Search CenterWatch for Basal Cell Carcinoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Basal Cell Carcinoma

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Anatomical Context for Basal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Basal Cell Carcinoma:

32
Skin, Prostate, Breast, Lung, Smooth muscle, Bone, Thyroid, T cells, Eye, Salivary gland, Testes, Endothelial, Cervix, Bone marrow, Uterus, Ovary, Testis, Colon, Brain, Lymph node, Trachea

Animal Models for Basal Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Basal Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537811.4SHH, GLI1, CYP1A1, MC1R, ROR2, RASA1
2MP:000538211.4GAS1, SHH, MC1R, ROR2, RASA1, PTCH1
3MP:000538511.3GAS1, SHH, CYP1A1, ROR2, RASA1, PTCH2
4MP:000537711.3GAS1, SHH, MC1R, ROR2, RASA1, SMO
5MP:000538111.3SHH, GLI1, ROR2, RASA1, PTCH2, PTCH1
6MP:000538011.1GAS1, SHH, GLI1, ROR2, RASA1, PTCH1
7MP:000537111.0ROR2, GLI1, GAS1
8MP:000538810.9SMO, GLI1, HAS3
9MP:000301210.8SHH, GLI1, CYP1A1, MC1R, RASA1, PTCH1

Publications for Basal Cell Carcinoma

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50PubMed
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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1540)
idTitleAuthorsYear
1
Medullary thyroid carcinoma and 2q37 deletion in a patient with nevoid basal cell carcinoma syndrome: clinical description and genetic analysis. (22319002)
2013
2
Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with decreased risk for basal cell carcinoma. (23299466)
2013
3
Basal Cell Carcinoma Metastatic to Parotid Gland. (24234479)
2013
4
Vismodegib for periocular and orbital Basal cell carcinoma. (24136169)
2013
5
Cathepsin K expression in basal cell carcinoma. (22220587)
2013
6
Agreement between histological subtype on punch biopsy and surgical excision in primary basal cell carcinoma. (22691131)
2013
7
Comments on the giant basal cell carcinoma--author reply. (23894758)
2013
8
Treatment of nodular basal cell carcinoma with cryotherapy and reduced protocol of imiquimod. (23270198)
2012
9
Concurrent primary and secondary myiasis on basal cell carcinoma. (22570036)
2012
10
Basal cell carcinoma in skin of color. (22453586)
2012
11
Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. (22158557)
2012
12
Nevoid basal cell carcinoma syndrome (Gorlin-Goltz syndrome). (23633824)
2012
13
Giant basal cell carcinoma: a series of 37 cases without metastasis. (22634697)
2012
14
Reconstruction for basal cell carcinoma in an anatomical region where the sun does not shine: an attractive option! (22391353)
2012
15
Giant epithelial malignancies (Basal cell carcinoma, squamous cell carcinoma): a series of 20 tumors from a single center. (22557850)
2012
16
Basal cell carcinoma rebound after cessation of vismodegib in a nevoid basal cell carcinoma syndrome patient. (22805146)
2012
17
Relation between expression pattern of p53 and survivin in cutaneous basal cell carcinomas. (21358596)
2011
18
Mediastinal fetal rhabdomyoma in nevoid basal cell carcinoma syndrome: a case report and review of the literature. (21710240)
2011
19
Eyelid basal cell carcinoma associated with solitary neurofibroma. (19614728)
2010
20
Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma: further explanation of a dose-escalating pilot study conducted primarily to consider the safety of this pharmacological modification. (19903172)
2010
21
Multiple basal cell carcinomas arising on a thermal-burn scar. Successful treatment with photodynamic therapy. (18624869)
2009
22
Treatment of basal cell carcinomas in patients with nevoid basal cell carcinoma syndrome. (19207641)
2009
23
Pseudocarcinomatous hyperplasia with follicular differentiation overlying basal cell carcinoma. (19590419)
2009
24
Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid Basal cell carcinoma syndrome. (18347458)
2008
25
Basal cytokines profile in metastatic renal cell carcinoma patients treated with subcutaneous IL-2-based therapy compared with that of healthy donors. (17953739)
2007
26
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. (17414450)
2007
27
Polymorphisms in the DNA repair gene XRCC1 associated with basal cell carcinoma and squamous cell carcinoma of the skin in a Korean population. (17355263)
2007
28
Identification of a novel mutation in the PTCH gene in a Korean family with naevoid basal cell carcinoma syndrome. (16780502)
2007
29
Photodynamic therapy of nodular basal cell carcinoma with multifiber contact light delivery. (16566732)
2006
30
Determination of p53 expression in basal cell carcinoma tissues and adjacent nontumoral epidermis from sun-exposed areas of the head and neck. (16649377)
2006
31
Management of primary superficial basal cell carcinoma. (16751865)
2006
32
Cysts of the jaws and advances in the diagnosis and management of nevoid Basal cell carcinoma syndrome. (18088795)
2005
33
Basal cell carcinoma with matrical differentiation: a case study with analysis of beta-catenin. (15701088)
2005
34
Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study on a large series of cases. (15270884)
2004
35
Cornification (keratinization) in Basal cell carcinoma: a histopathological and immunohistochemical study of 16 cases. (15492437)
2004
36
Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinoma. (12632089)
2003
37
Sub-populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation. (11168750)
2001
38
Expression of stromelysin 3 in basal cell carcinomas. (11701402)
2001
39
Imiquimod 5% cream in the treatment of superficial basal cell carcinoma: results of a multicenter 6-week dose-response trial. (11312429)
2001
40
Odontogenic keratocysts in a 5-year-old: initial manifestations of nevoid basal cell carcinoma syndrome. (10730288)
2000
41
Empty sella syndrome in nevoid basal cell carcinoma syndrome. (10838118)
2000
42
Expression of p53 in arsenic-related and sporadic basal cell carcinoma. (10677095)
2000
43
Heat shock protein HSP 27 is expressed in all types of basal cell carcinoma in low and high risk UV exposure groups. (10356405)
1999
44
Abnormal DNA synthesis activity induced by X-rays in nevoid basal cell carcinoma syndrome cells. (9388465)
1997
45
Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. (9354432)
1997
46
Clinical findings in two African-American families with the nevoid basal cell carcinoma syndrome (NBCC). (8042672)
1994
47
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. (1469302)
1992
48
Medulloblastoma in the nevoid basal-cell carcinoma syndrome: case reports and review of the literature. (2098052)
1990
49
The nevoid basal cell carcinoma syndrome--Gorlin's syndrome. Multiple jaw cysts and skin cancer. (2799659)
1989
50
Adenoid cystic basal cell carcinoma (adenocarcinoma); report of a case. (14815934)
1951

Genetic Variations for Basal Cell Carcinoma

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Expression for genes affiliated with Basal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Basal Cell Carcinoma

Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

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29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2SMO, PTCH1, PTCH2, MC1R, GLI1, SHH
2
Hide members
11.0PTCH1, PTCH2, GLI1, SHH, GAS1
311.0SMO, PTCH1, PTCH2, GLI1, SHH
411.0GAS1, SHH, PTCH2, PTCH1, SMO
510.9SHH, GLI1, PTCH2, PTCH1
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.9SHH, GLI1, PTCH1, SMO
710.9SMO, PTCH1, GLI1, SHH
810.7PTCH1, SHH

Compounds for genes affiliated with Basal Cell Carcinoma

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44Novoseek, 59Tocris Bioscience
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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cyclopamine44 5912.0SMO, PTCH1, GLI1, SHH
220(s)-hydroxycholesterol5910.7SHH, GLI1
3ay 9944 dihydrochloride5910.7GLI1, SHH
4ciliobrevin a5910.6SHH, GLI1
5sant-15910.4SHH, GLI1

GO Terms for genes affiliated with Basal Cell Carcinoma

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16Gene Ontology
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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:07237210.8SMO, PTCH1, GLI1

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of smoothened signaling pathwayGO:04588011.3SMO, GLI1, SHH, GAS1
2smoothened signaling pathwayGO:00722411.3SMO, PTCH1, GLI1, SHH
3smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193811.2SMO, GLI1, SHH
4somite developmentGO:06105311.2SHH, PTCH1, SMO
5renal system developmentGO:07200111.2SHH, PTCH1, SMO
6dorsal/ventral neural tube patterningGO:02190411.1SMO, SHH, GAS1
7regulation of smoothened signaling pathwayGO:00858911.1PTCH1, GLI1, GAS1
8negative regulation of smoothened signaling pathwayGO:04587911.1GAS1, PTCH2, PTCH1
9dorsal/ventral pattern formationGO:00995311.1PTCH1, GLI1, SHH
10camera-type eye developmentGO:04301011.1CYP1A1, SHH, GAS1
11vasculogenesisGO:00157011.1SHH, RASA1, SMO
12epidermis developmentGO:00854411.1PTCH1, PTCH2, KRT31
13negative regulation of canonical Wnt receptor signaling pathwayGO:09009011.0ROR2, GLI1, SHH
14ventral midline developmentGO:00741811.0SHH, GLI1
15positive regulation of hh target transcription factor activityGO:00722811.0SHH, SMO
16determination of left/right asymmetry in lateral mesodermGO:00314011.0SHH, SMO
17cerebellar cortex morphogenesisGO:02169611.0SMO, GLI1
18cellular response to cholesterolGO:07139710.9PTCH1, SMO
19intermediate filament organizationGO:04510910.9SHH, KRT20
20mammary gland epithelial cell differentiationGO:06064410.9PTCH1, SMO
21thalamus developmentGO:02179410.8SHH, SMO
22positive regulation of protein import into nucleusGO:04230710.8SMO, SHH
23spinal cord motor neuron differentiationGO:02152210.8SHH, PTCH1
24cell fate specificationGO:00170810.7SHH, SMO
25protein localization to nucleusGO:03450410.7SMO, SHH
26positive regulation of neuroblast proliferationGO:00205210.6SMO, SHH
27neuron fate commitmentGO:04866310.4SMO, SHH

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patched bindingGO:00511310.8SMO, PTCH1, SHH
2hedgehog receptor activityGO:00815810.7PTCH1, PTCH2
3smoothened bindingGO:00511910.6PTCH1, PTCH2
4hedgehog family protein bindingGO:09710810.4PTCH1, PTCH2

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet