Basal Cell Carcinoma malady

Wikipedia: Basal-cell carcinoma (BCC), a skin cancer, is the most common cancer. It rarely metastasizes or kills....⁴⁴ more...

MalaCards: Basal Cell Carcinoma, also known as basal cell cancer, is related to carcinoma and nevoid basal cell carcinoma syndrome. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Basal cell carcinoma and Hedgehog signaling pathway. The drugs carmustine and fluorouracil and the compounds h2o2 and sp 600125 have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, skeletal muscle and lung, and related mouse phenotypes are craniofacial and hematopoietic system.

Aliases & Descriptions:

basal cell carcinoma 6 7 8 33 43 basal cell cancer 6 32 43 malignant basal cell tumor 6 43 basal cell neoplasm 6 43 malignant basal cell tumor (morphologic abnormality) 6 basal cell carcinoma nos (morphologic abnormality) 6 basal cell neoplasm nos (morphologic abnormality) 6 basal cell carcinoma (morphologic abnormality) 6 basal cell neoplasm (morphologic abnormality) 6

basal cell tumor (morphologic abnormality) 6 basal cell carcinoma of skin (disorder) 6 epithelioma basal cell (disorder) 6 malignant basal cell neoplasm 6 basal cell carcinoma of skin 6 carcinoma basal cell 32 basal cell tumor 6 rodent ulcer 6 carcinoma 43

Disease types for basal cell carcinoma family:

basal cell carcinoma 1	basal cell carcinoma 2
basal cell carcinoma 3	basal cell carcinoma 4
basal cell carcinoma 5	basal cell carcinoma 6

Diseases related to basal cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1706)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	49.2	ZNF189, KLF14, KLF6, KIF4B, SFRP2, RCC2
2	nevoid basal cell carcinoma syndrome	42.1	KIF7, PCNA, SAP18, XPA, MMP3, GSTM1
3	renal cell carcinoma	38.8	PCNA, BRAF, VEGFA, RARB, BIRC5, BCL2L1
4	prostate carcinoma	38.5	KLF6, NBN, VEGFA, VDR, BMP6, MXI1
5	trichoepithelioma	37.9	BCL2, CDKN2B, CD34, CDH1, IVL, MME
6	hepatitis	37.7	GZMB, FASLG, IFNA1, IFNA2, ALB, KRT8
7	superficial basal cell carcinoma	36.8	BCL2, JAG1, MME, IFNA1, DLL1, NOTCH1
8	papillary thyroid carcinoma	36.8	BRAF, RARA, RARB, LGALS3, BAX, CD44
9	nodular basal cell carcinoma	36.8	BFSP1, HYAL3, HMMR, KRT31, KRT35, HAS3
10	hepatocellular carcinoma	36.5	KLF6, SFRP2, PCNA, BTC, BTRC, RBP1
11	adenoid cystic carcinoma	36.0	PCNA, LGALS3, MUC1, S100B, CDH1, MKI67
12	neuroendocrine carcinoma	35.7	MUC1, S100B, CDH1, FHIT, TP63, KRT8
13	adrenocortical carcinoma	35.2	BRAF, BMP2, S100B, MME, FGF2, IGFBP2
14	squamous cell carcinoma	35.0	RBP1, LGALS1, LGALS3, CD44, CDH1, MMP10
15	lung carcinoma	34.9	KLF6, PCNA, NBN, BRAF, VEGFA, LMNA
16	small cell carcinoma	34.8	KLF6, PCNA, VEGFA, MYCN, BCL2, CHEK2
17	xeroderma pigmentosum	34.8	PCNA, LMNA, BCL2, BAX, XRCC1, XRCC3
18	mucoepidermoid carcinoma	34.6	PCNA, MUC1, IVL, MKI67, TP63, CREB1
19	thyroiditis	34.3	PCNA, GC, BTC, NBN, SELE, BRAF
20	liver cirrhosis	34.2	CD34, ITGB1, MMP3, MCM2, FAP, IFNA1
21	merkel cell carcinoma	34.1	PCNA, BIRC5, BCL2, CHKB, MUC1, BAX
22	familial medullary thyroid carcinoma	34.1	BRAF, MYCN, LGALS3, TNC, CREB1, NOTCH1
23	papillary renal cell carcinoma	34.0	PCNA, VEGFA, MUC1, CD44, MME, MMP11
24	hepatitis c	33.5	JUN, MMP1, IL10, IL4, IFNA1, IFNA2
25	adenosquamous carcinoma	33.4	PCNA, MUC1, CDKN2A, IVL, MKI67, TP53
26	parathyroid carcinoma	33.2	LGALS3, MKI67, GSK3B, CCND1, TP53, TERT
27	breast carcinoma	33.2	PCNA, BTC, RBP1, NBN, SELE, BRAF
28	chromophobe renal cell carcinoma	33.1	PCNA, RARB, MUC1, MME, CCND1, HNF1B
29	renal oncocytoma	33.1	PCNA, MUC1, MME, CCND1, TP53, KRT8
30	thyroid carcinoma	33.1	PCNA, NBN, SELE, BRAF, VEGFA, VDR
31	keratosis	33.1	PCNA, LMNA, LMNB1, MYC, BCL2, SAT1
32	skin carcinoma	33.0	LAMC2, CDH1, IVL, MMP2, GSTM1, GSTT1
33	anaplastic carcinoma	32.9	BRAF, LGALS1, LGALS3, MUC1, CDH1, FOXE1
34	large cell carcinoma	32.8	BCL2, BAX, MCL1, TP53, TP63, PTHLH
35	bronchogenic carcinoma	32.8	CDKN2A, MGST1, GSTM3, IL10, MDM2, TP53
36	pleomorphic carcinoma	32.5	MUC1, IVL, TP53, PDPN, KRT8, KRT18
37	multiple endocrine neoplasia	32.5	JUN, CDKN2B, CDKN2A, CDH1, FGF2, APC
38	lymphoepithelioma-like carcinoma	32.4	BCL2, MUC1, S100B, CDH1, TP53, TNFRSF8
39	basal cell carcinoma, somatic	32.3	RASA1, PTCH1, PTCH2, SMO
40	thyroid medullary carcinoma	32.3	BRAF, LGALS3, CKS1B, MSH2, MLH1, MKI67
41	ductal carcinoma in situ	32.3	PCNA, VEGFA, RARA, RARS, BIRC5, BCL2
42	pleomorphic adenoma	32.3	PCNA, BMP2, MUC1, S100B, MDM2, ERBB2
43	pancreatitis	32.2	KLF6, SFRP2, PCNA, GC, BTC, BTRC
44	thymic carcinoma	32.2	BCL2, MUC1, CCL5, TP63, PTGS2, PTHLH
45	non-small cell lung carcinoma	32.2	PCNA, BRAF, VEGFA, MYC, BMP2, BIRC5
46	esophagitis	32.1	KLF6, SFRP2, PCNA, RBP1, NBN, SELE
47	verrucous carcinoma	32.0	PCNA, CDKN2A, CD44, CDH1, MDM2, CCND1
48	nevus	31.9	PCNA, SELE, BRAF, BMP6, BCL2, MXI1
49	pituitary carcinoma	31.9	PCNA, LGALS3, MUC1, ERBB2, TP53, GFAP
50	actinic keratosis	31.7	PCNA, LMNA, LMNB1, MYC, BCL2, CFLAR

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, fluorouracil, nilutamide

MalaCards organs/tissues related to basal cell carcinoma:

²²

MGI Mouse Phenotypes related to basal cell carcinoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	13.0	NBN, LMNB1, LMNB2, MYCN, BMP4, RASA1
2	hematopoietic system phenotype	MP:0005397	12.4	KLF6, PCNA, BTRC, RBP1, NBN, BRAF
3	mortality/aging	MP:0010768	12.2	KLF6, KIF7, SFRP2, BTC, BTRC, SELE
4	endocrine/exocrine gland phenotype	MP:0005379	12.1	SFRP2, NBN, LGR5, MXI1, XPA, AXIN2
5	respiratory system phenotype	MP:0005388	12.0	LMNB2, MYCN, LGR5, FZD3, F13A1, GLI2
6	immune system phenotype	MP:0005387	11.9	BTRC, RBP1, NBN, BRAF, VDR, LMNA
7	renal/urinary system phenotype	MP:0005367	11.3	BRAF, LMNA, MYCN, BMP4, RARA, RARB
8	behavior/neurological phenotype	MP:0005386	10.8	NBN, SELE, BRAF, LMNA, MYCN, BMP4
9	limbs/digits/tail phenotype	MP:0005371	10.4	KIF7, SFRP2, VEGFA, VDR, LMNA, MYCN
10	other phenotype	MP:0005395	9.9	RARA, RARB, LAMA5, LAMC2, AXIN1, MSR1
11	liver/biliary system phenotype	MP:0005370	9.6	KLF6, RBP1, VEGFA, MYCN, BMP4, SAT1
12	reproductive system phenotype	MP:0005389	9.2	KLF6, SFRP2, BTRC, RBP1, NBN, VEGFA
13	vision/eye phenotype	MP:0005391	7.4	KIF7, RBP1, SELE, BRAF, VEGFA, LMNA
14	muscle phenotype	MP:0005369	INF	SFRP2, BTC, BRAF, VEGFA, LMNA, LMNB1
15	integument phenotype	MP:0010771	INF	KLF6, BRAF, LMNB1, LMNB2, , BCL2
16	tumorigenesis	MP:0002006	INF	BTRC, NBN, BRAF, , RARA, BCL2
17	pigmentation phenotype	MP:0001186	INF	RBP1, BRAF, LMNA, , BCL2, LEF1
18	homeostasis/metabolism phenotype	MP:0005376	INF	KIF7, SFRP2, GC, BTC, RBP1, SELE
19	nervous system phenotype	MP:0003631	INF	KIF7, SFRP2, RBP1, NBN, BRAF, LMNA
20	cellular phenotype	MP:0005384	INF	KLF6, KIF7, SFRP2, PCNA, BTRC, NBN
21	skeleton phenotype	MP:0005390	INF	KIF7, GC, BTC, BRAF, VEGFA, VDR
22	cardiovascular system phenotype	MP:0005385	INF	KLF6, SFRP2, BTC, SELE, BRAF, VEGFA
23	growth/size phenotype	MP:0005378	INF	KLF6, SFRP2, BTC, RBP1, NBN, SELE
24	no phenotypic analysis	MP:0003012	INF	KIF7, SFRP2, PCNA, VEGFA, VCAM1, BNC1
25	embryogenesis phenotype	MP:0005380	INF	KLF6, KIF7, SFRP2, NBN, BRAF, LMNB1
26	hearing/vestibular/ear phenotype	MP:0005377	INF	RBP1, VDR, LMNA, , BMP2, BMP4
27	normal phenotype	MP:0002873	INF	SFRP2, BTC, SELE, BRAF, VEGFA, LMNA
28	adipose tissue phenotype	MP:0005375	INF	BRAF, LMNA, , BCL2, LEF1, SAT1
29	digestive/alimentary phenotype	MP:0005381	INF	BRAF, VEGFA, VDR, LMNA, , MYCN

Articles related to basal cell carcinoma:

(show top 50)    (show all 387)

id	Title	Authors	Year	Affiliating Genes
1	An immunohistochemical study of laminin in basal cell carcinoma. (19615022)	Mostafa W.Z.... El-Nabarawy E.	2010	LAMA5
2	Immunohistochemical FHIT expression still exists in e arly lesions of basal cell carcinoma. (20399571)	Kiyici H.... Demirhan B.	2010	FHIT
3	Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome). (20223301)	Ueda M.... Ogawa O.	2010	PTCH1
4	Nestin expression in stromal cells of trichoblastoma and basal cell carcinoma. (20337823)	Misago N.... Narisawa Y.	2010	NES
5	Endothelin-2 is upregulated in basal cell carcinoma u nder control of Hedgehog signaling pathway. (19914214)	Tanese K.... Sakamoto M.	2010	EDN2
6	A novel missense mutation in the PTCH1 gene in a premature case of nevoid basal cell carcinoma syndrome. (19213655)	Nakamura M.... Tokura Y.	2009	PTCH1
7	The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas. (19278423)	Oh S.T.... Reichrath J.	2009	ADAM10, ADAM12, ADAM17
8	Inhibition of the hedgehog pathway in advanced basal- cell carcinoma. (19726763)	Von Hoff D.D.... Low J.A.	2009	PTCH1
9	Neuronal differentiation in basal cell carcinoma: pos sible relationship to Hedgehog pathway activation? (19479712)	Gore S.M.... Philpott M.P.	2009	TUBB3
10	Nevoid Basal cell carcinoma syndrome: a cephalometric study of patients and controls. (19165028)	Leonardi R.... Lo Muzio L.	2009	PTCH1
11	Localization of telomerase hTERT protein in frozen se ctions of basal cell carcinomas (BCC) and tumor margin tissues. (19885561)	Fabricius E.M.... Hoffmeister B.	2009	TERT
12	Keloidal basal cell carcinoma: not a distinctive clin icopathological entity. (18795924)	Jones M.... BAPer A.	2009	CD36
13	SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. (18333897)	Vidal V.P.... Schedl A.	2008	SOX9
14	The contribution of melanocortin 1 receptor gene polymorphisms and the agouti signalling protein gene 8818A>G polymorphism to cutaneous melanoma and basal cell carcinoma in a Polish population. (18637131)	Brudnik U.... Kanas P.	2008	MC1R, ASIP
15	Multiple intracranial meningiomas causing papilledema and visual loss in a patient with nevoid Basal cell carcinoma syndrome. (18347458)	Pribila J.T.... Trobe J.D.	2008	PTCH1
16	A novel germ-line mutation of PTCH1 gene in a Japanese family of nevoid basal cell carcinoma syndrome: are the palmoplantar pits associated with true basal cell carcinoma? (18436435)	Otsubo S.... Iizuka H.	2008	PTCH1
17	Immunohistochemical demonstration of D2-40 in basal cell carcinomas of the skin. (18537863)	Ishida M.... Okabe H.	2008	KRT17
18	Immunolabeling pattern of cytokeratin 19 expression may distinguish sebaceous tumors from basal cell carcinomas. (18095993)	Heyl J.... Mehregan D.	2008	KRT19
19	Early-onset of sporadic basal-cell carcinoma: germline mutations in the TP53, PTCH, and XPD genes. (18246963)	Suarez-Martinez E.B.... Matta J.L.	2007	ERCC2, PTCH1
20	In situ identification of genes regulated specifically in fibroblasts of human basal cell carcinoma. (17273163)	Micke P.... Ostman A.	2007	SFRP2, ANGPTL2, PDGFRL
21	Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. (16582078)	R Yang X.... Goldstein A.M.	2006	CYP1A1, CYP2D6, GSTT1
22	Case-control study in basal cell carcinoma of the skin: single nucleotide polymorphisms in three interleukin promoters pre-analysed in pooled DNA. (17107380)	Wilkening S.... Forsti A.	2006	IL6, IL1B, IL10
23	MC1R and PTCH gene polymorphism in French patients with basal cell carcinomas. (16645598)	Liboutet M.... Soufir N.	2006	PTCH1, MC1R
24	Germline mutations of the PTCH gene in families with odontogenic keratocysts and nevoid basal cell carcinoma syndrome. (16675912)	Song Y.L.... Bian Z.	2006	PTCH1
25	CD10 expression in trichoepithelioma and basal cell carcinoma. (16420307)	Pham T.T.... Herman C.	2006	MME
26	Pigmentation in basal cell carcinoma involves enhanced endothelin-1 expression. (15946241)	Lan C.C.... Yu H.S.	2005	EDN1
27	The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas. (16179495)	Basyuk E.... Journot L.	2005	PLAGL1
28	Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L. (14767779)	Frohlich E.... Klessen C.	2004	CTSH
29	Mutation spectra of epidermal p53 clones adjacent to basal cell carcinoma and squamous cell carcinoma. (15447725)	BAockvall H.... Ponten F.	2004	TP53
30	Granular cell basal cell carcinoma. (14961915)	Dundr P.... VosmA-k F.	2004	CD68
31	Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis. (15377354)	Vidal D.... Alomar A.	2004	TP53, BCL2
32	Nonsolitary giant perianal trichoepithelioma with malignant transformation into basal cell carcinoma: report of a case and review of the literature. (15073659)	Martinez C.A.... Waisberg J.	2004	BCL2
33	Role for Id-1 in immunobiology of normal keratinocytes and in basal cell carcinoma. (12823438)	Chaturvedi V.... Nickoloff B.J.	2003	ID1
34	Twelve single nucleotide polymorphisms on chromosome 19q13.2-13.3: linkage disequilibria and associations with basal cell carcinoma in Danish psoriatic patients. (12645871)	Yin J.... Nexo B.A.	2003	ERCC2, ERCC1
35	CD44 is exposed to the extracellular matrix at invasi ve sites in basal cell carcinomas. (11896210)	Dingemans K.P.... Pals S.T.	2002	CD44
36	Bcl-2-related proteins, alpha-smooth muscle actin and amyloid deposits in aggressive and non-aggressive basal cell carcinomas. (12575847)	Bozdogan O.... Caydere M.	2002	BCL2
37	Signet ring cell basal cell carcinoma: a basal cell carcinoma with myoepithelial differentiation. (11801794)	Kim Y.C.... Myong N.H.	2001	S100B, GFAP, ACTC1
38	Genetic determinants of basal cell carcinoma risk. (11340611)	Epstein E.	2001	PTCH1
39	Basaloid/follicular hyperplasia overlying connective tissue/mesenchymal hamartomas simulating basal cell carcinomas. (11712034)	Stashower M.E.... Skelton H.G.	2001	TP53, BCL2
40	Acrochordons as a presenting sign of nevoid basal cell carcinoma syndrome. (11312426)	Chiritescu E.... Maloney M.E.	2001	PTCH1
41	PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. (10029063)	Zaphiropoulos P.G.... Toftgard R.	1999	PTCH1, PTCH2
42	Early diagnosis of nevoid basal cell carcinoma syndrome. (10332131)	Lo Muzio L.... Procaccini M.	1999	PTCH1
43	Basal cell carcinoma with tumor epithelial and stromal giant cells: a variant of pleomorphic basal cell carcinoma. (10535579)	Meehan S.A.... Rouse R.V.	1999	BCL2, ACTC1
44	Decreased expression of galectin-3 in basal cell carcinoma of the skin. (10375595)	Castronovo V.... van den Brule F.A.	1999	LGALS3, LGALS1
45	Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. (9077484)	Lear J.T.... Fryer A.A.	1997	CYP1A1, GSTT1, GSTM3
46	No evidence of mutation in the human PTC gene, responsible for nevoid basal cell carcinoma syndrome, in human primary squamous cell carcinomas of the esophagus and lung. (9140104)	Suzuki K.... Nakamura Y.	1997	PTCH1
47	De novo mutations of the Patched gene in nevoid basal cell carcinoma syndrome help to define the clinical phenotype. (9415689)	Wicking C.... Chenevix-Trench G.	1997	PTCH1
48	Expression of retinoic acid receptor proteins in basal cell carcinomas: an immunohistochemical analysis. (8985133)	Kamradt J.... Reichrath J.	1996	RARA, MKI67, RARS
49	Analysis of p53 gene mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma. (8187055)	Konishi K.... Yasuno H.	1994	TP53
50	Increased expression of matrix metalloproteinase-3 (stromelysin-1) in cultured fibroblasts and basal cell carcinomas of nevoid basal cell carcinoma syndrome. (7916987)	Majmudar G.... Johnson T.M.	1994	MMP3

Genes related to basal cell carcinoma according to GeneCards:

(show top 50)    (show all 351)

id	Symbol	Description	Score	GeneCards Section Context
1	PTCH2	patched 2	11.1	Summaries, Pathways & Interactions, Functions, Publications
2	RASA1	RAS p21 protein activator (GTPase activating protein) 1	11.1	Summaries, Publications
3	BCC1	Basal cell carcinoma, susceptibility to, 1	11.1	Aliases & Descriptions
4	BCC2	Basal cell carcinoma, susceptibility to, 2	11.1	Aliases & Descriptions
5	BCC3	Basal cell carcinoma, susceptibility to, 3	11.1	Aliases & Descriptions
6	BCC4	Basal cell carcinoma, susceptibility to, 4	11.1	Aliases & Descriptions
7	BCC5	Basal cell carcinoma, susceptibility to, 5	11.1	Aliases & Descriptions
8	BCC6	Basal cell carcinoma, susceptibility to, 6	11.1	Aliases & Descriptions
9	SHH	sonic hedgehog	11.1	Publications, Pathways & Interactions, Summaries
10	GLI1	GLI family zinc finger 1	11.1	Summaries, Pathways & Interactions, Publications
11	PTCH1	patched 1	11.0	Pathways & Interactions, Publications
12	SMO	smoothened, frizzled family receptor	11.0	Pathways & Interactions, Publications
13	GAS1	growth arrest-specific 1	11.0	Publications
14	ROR2	receptor tyrosine kinase-like orphan receptor 2	11.0
15	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	11.0	Publications
16	HYAL3	hyaluronoglucosaminidase 3	11.0	Publications
17	KRT35	keratin 35	11.0
18	MCRS1	microspherule protein 1	11.0	Publications
19	HAS3	hyaluronan synthase 3	11.0	Publications
20	DLL1	delta-like 1 (Drosophila)	11.0	Publications
21	SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	11.0	Publications
22	MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	11.0	Publications
23	C2orf27A	chromosome 2 open reading frame 27A	11.0
24	HMMR	hyaluronan-mediated motility receptor (RHAMM)	11.0	Publications
25	XPA	xeroderma pigmentosum, complementation group A	11.0	Publications
26	JAG1	jagged 1	11.0	Publications
27	FAP	fibroblast activation protein, alpha	11.0	Publications
28	SUFU	suppressor of fused homolog (Drosophila)	11.0	Pathways & Interactions, Publications
29	HPSE	heparanase	11.0	Publications
30	KRT20	keratin 20	11.0	Publications
31	BFSP1	beaded filament structural protein 1, filensin	11.0
32	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications
33	MME	membrane metallo-endopeptidase	11.0	Publications
34	NOTCH1	notch 1	11.0	Publications
35	FANCC	Fanconi anemia, complementation group C	11.0	Publications
36	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
37	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
38	GPR107	G protein-coupled receptor 107	11.0
39	TLR7	toll-like receptor 7	11.0
40	GSTM1	glutathione S-transferase mu 1	11.0	Publications
41	PCNA	proliferating cell nuclear antigen	11.0	Publications
42	TP53	tumor protein p53	11.0	Pathways & Interactions, Publications
43	IFNA1	interferon, alpha 1	11.0	Publications
44	EDN1	endothelin 1	11.0	Publications
45	MSSE	multiple self-healing squamous epithelioma	11.0	Publications
46	RMRP	RNA component of mitochondrial RNA processing endoribonuclease	11.0	Publications
47	SPATA19	spermatogenesis associated 19	11.0	Publications
48	CD3EAP	CD3e molecule, epsilon associated protein	11.0	Publications
49	KIF4B	kinesin family member 4B	11.0
50	WNT8A	wingless-type MMTV integration site family, member 8A	11.0	Pathways & Interactions

Pathways related to basal cell carcinoma according to GeneDecks:

(show top 50)    (show all 201)

id	Pathway	Score	Top Affiliating Genes
1	Basal cell carcinoma20	13.7	BMP2, BMP4, LEF1, AXIN1, AXIN2, FZD1
2	Hedgehog signaling pathway20	12.9	BTRC, BMP2, BMP4, BMP6, GSK3B, GLI1
3	Human Embryonic Stem Cell Pluripotency36	12.8	BMP2, BMP4, LEF1, AXIN1, FZD1, FZD10
4	Wnt Signaling Pathway37	12.6	BTRC, LGR5, LEF1, AXIN1, AXIN2, FZD1
5	Melanogenesis20	12.6	LEF1, FZD1, FZD10, FZD2, FZD3, FZD4
6	Wnt / Hedgehog / Notch3	12.4	LEF1, AXIN1, AXIN2, FZD5, FZD6, JAG1
7	Presenilin-Mediated Signaling36	12.3	BTRC, BCL2, BCL2L1, AXIN1, FZD1, FZD10
8	Hedgehog Signaling in Mammals36	11.6	BMP2, BMP4, BMP6, TUBB3, PTCH2, SUFU
9	Reelin Pathway (Cajal-Retzius cells)36	11.4	AXIN1, FZD1, FZD10, FZD2, FZD3, FZD4
10	Factors Promoting Cardiogenesis in Vertebrates36	11.4	BMP2, LEF1, AXIN1, ATF2, FZD1, FZD10
11	Actin-Based Motility by Rho Family GTPases36	11.3	BTC, BMP4, ITGA4, ITGA6, ITGAV, ITGB4
12	G12-G13 in Cellular Signaling36	11.3	RASA1, AXIN1, FZD1, FZD10, FZD2, FZD3
13	Translation_Non-genomic (rapid) action of Androgen Receptor41	11.1	FZD1, FZD10, FZD2, FZD3, FZD4, FZD5
14	Transcription Androgen Receptor nuclear signaling10	11.0	FZD1, FZD10, FZD2, FZD3, FZD4, FZD5
15	Transcription_Androgen Receptor nuclear signaling41	11.0	FZD1, FZD10, FZD2, FZD3, FZD4, FZD5
16	Glioma Invasiveness36	10.9	BTC, BMP2, BMP4, BMP6, CD44, ITGA3
17	Glioblastoma Multiforme36	10.6	BRAF, LEF1, AXIN1, FZD1, FZD10, FZD2
18	GSK3 Signaling36	9.9	BTC, BTRC, BMP2, BMP4, BMP6, LEF1
19	Angiogenesis3	9.9	JAG1, ITGA6, ITGAV, ITGB1, MMP2, FGF2
20	Nanog in Mammalian ESC Pluripotency36	9.9	BTC, BRAF, BMP2, BMP4, BMP6, AXIN1
21	PTEN Pathway36	9.8	BTC, BRAF, BMP2, BMP4, LAMA5, LAMB2
22	Akt Signaling36	9.7	BTC, BMP2, BMP4, CD80, ITGA2, ITGA6
23	Rac1 Pathway36	9.5	BTC, BMP4, BMP6, JUN, ITGA2, ITGA3
24	PPAR Pathway36	9.3	BTC, BMP2, BMP4, ITGA2, ITGA3, ITGA4
25	Paxillin Interactions36	9.0	BTC, BMP2, BMP4, ITGA2, ITGA3, ITGA4
26	Ras Pathway36	8.9	BTC, BRAF, BMP2, BMP4, RASA1, ATF2
27	p53 Mediated Apoptosis36	8.9	BTC, BMP2, BMP4, BMP6, BCL2, CHEK2
28	Apoptotic Pathways in Synovial Fibroblasts36	8.8	BTC, BMP2, BMP4, BMP6, CFLAR, AREG
29	Rho Family GTPases36	8.8	BTC, BMP2, BMP4, BMP6, BCL2, BAX
30	Epithelial Adherens Junctions36	8.7	BTC, BMP2, BMP4, BMP6, LEF1, CDH1
31	Mitochondrial Apoptosis36	8.7	BTC, BMP2, BMP4, BMP6, BCL2, BCL2L1
32	Phospholipase-C Pathway36	8.6	BTC, BMP2, BMP4, BMP6, LAMA5, LAMB2
33	ILK Signaling36	8.6	BTC, BMP2, BMP4, LEF1, LAMA5, LAMB2
34	PAK Pathway36	8.4	BTC, BMP2, BMP4, BMP6, BCL2, BAX
35	Cellular Apoptosis Pathway36	8.4	BTC, BMP2, BMP4, BMP6, BCL2, BCL2L1
36	Focal adhesion20	8.3	BRAF, BCL2, LAMA5, LAMB2, LAMC2, JUN
37	Pancreatic Adenocarcinoma36	7.8	BTC, BRAF, BMP2, BMP4, BMP6, BIRC5
38	Antioxidant Action of Vitamin-C36	7.6	BTC, BMP2, BMP4, BMP6, BCL2, BAX
39	MAPK Family Pathway36	7.5	BTC, BRAF, BMP2, BMP4, BMP6, BCL2
40	p38 Signaling36	7.2	BTC, BMP2, BMP4, BMP6, BCL2, BAX
41	Tec Kinases Signaling36	6.9	BTC, BMP2, BMP4, BMP6, BCL2, BAX
42	Endothelin-1 Signaling Pathway36	INF	BRAF, , BMP2, BMP4, BMP6, CD80
43	WNT Signaling36	INF	BTRC, , BIRC5, LEF1, AXIN1, FZD1
44	JAK-STAT Pathway36	INF	BTC, , BMP2, BMP4, BMP6, BCL2
45	Small cell lung cancer20	INF	, RARB, BCL2, BCL2L1, CKS1B, LAMA5
46	Colorectal Cancer Metastasis36	INF	BRAF, , BIRC5, BCL2L1, LEF1, BAX
47	Endometrial cancer20	INF	BRAF, , AXIN1, CDH1, MLH1, ILK
48	Wnt signaling pathway20	INF	SFRP2, BTRC, , LEF1, AXIN1, AXIN2
49	MAPK Signaling36	INF	BTC, BRAF, , BMP2, BMP4, BMP6
50	Molecular Mechanisms of Cancer36	INF	, BMP2, BMP4, BMP6, RARA, RARB

Compounds related to basal cell carcinoma according to GeneDecks:

(show top 50)    (show all 397)

id	Compound	Score	Top Affiliating Genes
1	h2o232	10.9	LGALS3, SAT1, ATF2, MME, MGST1, IL5
2	sp 60012532 42	11.8	VCAM1, MMP1, MMP13, TP53
3	glyceraldehyde 3-phosphate32	10.8	MYCN, RARS, BIRC5, LGALS1, LGALS3, SAT1
4	glycosaminoglycan32	10.8	BMP2, CD36, CD44, MMP13, AREG, FGF2
5	hematoxylin32	10.7	PCNA, LGALS3, MUC1, S100B, CDKN2A, CD34
6	vincristine32 34 9 9	13.6	MYCN, ITGA4, FGF2, IFNA1, PTHLH, ODC1
7	calcipotriol32 42 9 9	13.5	GC, VDR, RARS, IVL, ITGB4, IL8
8	acitretin32 9 9	12.5	RBP1, RARA, RARS, RARB, IVL, IFNA1
9	oxygen32 18	11.4	BMP2, BIRC5, BCL2, BCL2L1, LGALS1, LGALS3
10	mitomycin c32	10.2	PCNA, NBN, VCAM1, BIRC5, XRCC3, XPA
11	fibrinogen32	10.2	KLF6, GC, SELE, VCAM1, PADI4, LGALS3
12	cyclic amp32 18	11.1	KLF6, BRAF, RARS, RARB, ATF2, JUN
13	arginine32	10.1	BRAF, VDR, BMP2, RARA, RARS, RARB
14	sulindac32 9 9	11.8	PCNA, BIRC5, BCL2, BCL2L1, BAX, SAT1
15	histamine32 18	10.6	PCNA, SELE, VCAM1, BMP6, RARS, CDH1
16	forskolin32 42 9 9	12.5	BRAF, BMP2, BMP4, BMP6, RARS, RARB
17	p00232	9.5	BRAF, BIRC5, MTHFR, XRCC1, CFLAR, CD44
18	cholesterol32 9 18 9	12.4	GC, SELE, VCAM1, LMNA, BMP2, BIRC5
19	glutamate32	9.3	PCNA, GC, BRAF, VDR, BMP6, LGALS3
20	pge232	9.2	SELE, VCAM1, BMP2, BMP4, SAT1, ATF2
21	aspartate32	9.1	PCNA, GC, BRAF, VDR, BMP6, RARA
22	cysteine32	9.0	PCNA, VDR, LMNB1, BMP4, RARA, RARB
23	formaldehyde32 18	10.0	PCNA, SELE, LGALS3, MUC1, S100B, CD44
24	glutamine32	9.0	PCNA, VDR, BMP6, LGALS1, LGALS3, CHKB
25	rapamycin32 42	9.7	NBN, BRAF, VEGFA, BMP2, BMP4, LGALS1
26	tgf beta132	8.6	VCAM1, BMP6, RARA, CDK6, CD36, CDKN2B
27	adenylate32	8.4	KLF6, GC, SELE, VDR, VCAM1, BMP4
28	agar32	8.4	BRAF, MYCN, RARA, RARB, BIRC5, LGALS1
29	thalidomide32 42 9 9	11.3	VEGFA, BIRC5, BCL2L1, CD36, FGF2, IL10
30	pd15303532	8.0	VEGFA, BIRC5, JUN, MMP1, AREG, ERBB2
31	vitamin d32	7.9	GC, VDR, BMP2, BMP6, RARA, RARS
32	sb 20358032 42	8.9	SELE, BRAF, VEGFA, VDR, VCAM1, BMP2
33	ag 147832	7.6	BTC, JUN, ITGA2, MMP2, AREG, IL8
34	doxorubicin32 34 9 9	10.4	NBN, SELE, MYCN, BMP6, BCL2L1, CHEK2
35	5fluorouracil32	7.3	PCNA, SELE, VEGFA, VDR, BIRC5, BCL2
36	hydrocortisone32 9 9	9.3	BMP6, MUC1, CD36, IVL, MMP1, MMP2
37	gefitinib32 34 9 9	10.2	VEGFA, BIRC5, BCL2L1, CDK6, CDH1, MMP2
38	testosterone32 9 18 9	10.0	PCNA, GC, SELE, VDR, VCAM1, BMP2
39	dexamethasone32 42 34 9 9	INF	PCNA, VEGFA, VDR, VCAM1, , BMP2
40	etoposide32 42 9 9	INF	PCNA, SELE, LMNB1, , MYCN, RARA
41	15-deoxy-delta-12,14-prostaglandin j232	INF	VEGFA, VCAM1, , BMP6, BIRC5, BCL2L1
42	cisplatin32 34 9 9	INF	PCNA, BRAF, VEGFA, , MYCN, BMP6
43	docetaxel32 34 9 9	INF	VEGFA, VDR, , BIRC5, BCL2, BCL2L1
44	vitamin a32 9 18 9	INF	GC, RBP1, VDR, , RARA, RARS
45	ribonucleic acid32	INF	KLF6, , BMP2, BMP4, BMP6, RARA
46	tacrolimus32 34 9 9	INF	PCNA, VDR, , BMP2, BMP6, CHKB
47	alanine32	INF	PCNA, SELE, BRAF, VDR, VCAM1, LMNA
48	glycogen32 18	INF	BTRC, , LGALS3, LEF1, CHKB, S100B
49	actinomycin d32	INF	SELE, VEGFA, VDR, , MYCN, BMP2
50	paclitaxel32 34 9 9	INF	PCNA, BRAF, VEGFA, LMNB1, , BMP6

Cellular components related to basal cell carcinoma according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	11.8	KRT15, KRT18, KRT38, KRT20, KRT35, KRT19
2	proteinaceous extracellular matrix	GO:005578	11.2	MMP11, WNT2B, WNT3, WNT3A, WNT4, WNT5A
3	basement membrane	GO:005604	10.7	TGFB2, DST, TIMP2, TIMP1, COL17A1, ITGB1
4	Axin-APC-beta-catenin-GSK3B complex	GO:034747	10.1	CTNNB1, APC, GSK3B, AXIN2, AXIN1
5	cell surface	GO:009986	10.0	VEGFA, VCAM1, BMP2, RARA, ITGA4, ITGAV
6	caveola	GO:005901	10.0	SMO, CTSB, PTGS2, PTCH1, TRPC4, FASLG
7	external side of plasma membrane	GO:009897	9.7	FASLG, ANPEP, TNF, CTSB, TGFBR2, CXCL12
8	extracellular region	GO:005576	9.5	IGFBP2, PLAU, NOTCH1, NOTCH2, NOTCH3, PDGFRL
9	membrane raft	GO:045121	9.3	SHH, EGFR, TDGF1, PRKCA, ADAM17, TEX101
10	plasma membrane	GO:005886	9.1	NRP1, SMO, PLAU, NOTCH1, NOTCH2, NOTCH3
11	perinuclear region of cytoplasm	GO:048471	8.8	KRT18, NOS2, CTSB, CTNNB1, CYLD, EGFR
12	cytosol	GO:005829	8.8	CTSH, CTNNB1, PPARG, NRP1, NQO1, NOS2
13	extracellular space	GO:005615	8.1	TGFA, WNT16, WNT2B, WNT3, WNT3A, WNT4
14	nucleoplasm	GO:005654	INF	TERT, TP63, TP53, ERCC1, ERCC2, CCND1
15	cytoplasm	GO:005737	INF	FOXM1, APC2, MCL1, MCRS1, FANCC, MAP7
16	nucleus	GO:005634	INF	PTEN, TP63, TP53, ERCC1, ERBB2, PTGS2

Biological processes related to basal cell carcinoma according to GeneDecks:

(show top 50)    (show all 105)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuron differentiation	GO:030182	12.4	FZD1, FZD10, FZD2, FZD3, FZD4, FZD5
2	cellular response to retinoic acid	GO:071300	12.0	RARA, FZD10, FZD4, FZD7, SOX9, WNT10B
3	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	11.6	SFRP2, LEF1, AXIN2, FZD6, GSK3B, APC
4	Wnt receptor signaling pathway	GO:016055	11.6	BTRC, LEF1, FZD4, CD44, APC2, CYLD
5	epidermis development	GO:008544	11.6	BNC1, LAMC2, CDSN, CDKN2A, PTHLH, CRABP2
6	cell-cell signaling	GO:007267	11.5	SFRP2, BMP2, FZD1, FZD2, CD80, ASIP
7	negative regulation of smoothened signaling pathway	GO:045879	11.3	KIF7, BTRC, GLI3, PTCH1, PTCH2, SUFU
8	in utero embryonic development	GO:001701	11.1	BMP2, BCL2L1, AXIN1, MSH2, ITGB1, GLI3
9	response to retinoic acid	GO:032526	11.1	BMP2, BMP4, RARA, MAP7, IGFBP2, CTSH
10	odontogenesis of dentin-containing tooth	GO:042475	11.1	BMP2, BMP4, LEF1, BAX, LAMA5, ITGA6
11	hemidesmosome assembly	GO:031581	10.9	LAMC2, ITGA6, ITGB4, COL17A1, KRT5, KRT14
12	kidney development	GO:001822	10.6	BMP4, BMP6, LEF1, BAX, MME, APC
13	integrin-mediated signaling pathway	GO:007229	10.6	LAMA5, ITGA2, ITGA3, ITGA4, ITGA6, ITGAV
14	epithelial to mesenchymal transition	GO:001837	10.6	BMP2, LEF1, GSK3B, CTNNB1, NOTCH1, TGFB1
15	negative regulation of epithelial cell proliferation	GO:050680	10.5	SFRP2, BMP4, CDK6, CDKN2B, PTEN, TGFB1
16	positive regulation of osteoblast differentiation	GO:045669	10.4	SFRP2, BMP2, BMP4, BMP6, FGF2, IL6
17	heart development	GO:007507	10.3	PCNA, VCAM1, BMP2, ITGA4, ID1, GLI2
18	response to estradiol stimulus	GO:032355	10.0	GC, VDR, BMP4, RARA, IL1B, IGFBP2
19	positive regulation of gene expression	GO:010628	10.0	BRAF, VEGFA, VDR, BMP2, LEF1, CD34
20	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.8	FZD1, FZD2, FZD4, IL10, IL1B, IL4
21	positive regulation of apoptotic process	GO:043065	9.8	SFRP2, BMP2, BMP4, RARB, BAX, ITGA6
22	apoptotic process	GO:006915	9.8	NBN, LMNA, LMNB1, BIRC5, CLPTM1L, BCL2
23	virus-host interaction	GO:019048	9.8	BTRC, VCAM1, BAX, CFLAR, CD80, ITGA2
24	response to mechanical stimulus	GO:009612	9.7	BMP2, BMP4, JUN, IGFBP2, TNF, PTGER4
25	negative regulation of transcription, DNA-dependent	GO:045892	9.7	SFRP2, BTRC, VDR, BMP2, BMP4, RARA
26	cell proliferation	GO:008283	9.7	PCNA, NBN, BCL2L1, CKS1B, LAMA5, S100B
27	axon guidance	GO:007411	9.6	KIF4B, LAMB2, ITGA2, ITGAV, ITGB1, GSK3B
28	cellular response to organic cyclic compound	GO:071407	9.6	BTRC, BMP2, LGALS1, ITGA6, IL1B, CCL5
29	positive regulation of cell migration	GO:030335	9.5	VEGFA, BMP2, LEF1, CDH13, ITGAV, ITGB1
30	anti-apoptosis	GO:006916	9.4	BRAF, BIRC5, BCL2, BCL2L1, MUC1, CFLAR
31	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	BMP4, JUN, CDH13, IL6, CCL5, TNF
32	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.3	SFRP2, BRAF, VEGFA, BCL2, AXIN1, CD44
33	wound healing	GO:042060	9.3	KLF6, BNC1, FGF2, IL1B, ERBB2, PDGFRA
34	induction of apoptosis	GO:006917	9.2	BAX, CDKN2A, FASLG, IFNA2, ERCC2, TP63
35	positive regulation of endothelial cell proliferation	GO:001938	9.1	VEGFA, BMP2, BMP4, BMP6, JUN, CDH13
36	response to hypoxia	GO:001666	9.0	VEGFA, VCAM1, BMP2, BCL2, XRCC1, IL1B
37	angiogenesis	GO:001525	8.7	VEGFA, LAMA5, SAT1, JUN, JAG1, ITGAV
38	positive regulation of protein phosphorylation	GO:001934	8.5	VEGFA, BMP2, BMP4, AXIN1, AXIN2, FZD1
39	negative regulation of cell proliferation	GO:008285	8.5	SFRP2, VDR, BMP2, BMP4, RARB, RARRES3
40	signal transduction	GO:007165	8.3	BTRC, VDR, RARA, RARB, RASA1, LGALS1
41	epidermal growth factor receptor signaling pathway	GO:007173	8.1	GSK3B, MDM2, ERBB2, PTEN, CREB1, EGF
42	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	ZNF189, VDR, , BMP2, BMP4, RARB
43	negative regulation of apoptotic process	GO:043066	INF	BTC, BRAF, VEGFA, , BMP4, BCL2
44	positive regulation of cell proliferation	GO:008284	INF	SFRP2, BTC, NBN, VEGFA, BNC1,
45	positive regulation of transcription, DNA-dependent	GO:045893	INF	KLF6, BTRC, , BMP2, BMP4, RARA
46	response to drug	GO:042493	INF	SFRP2, NBN, , BCL2, LGALS1, XRCC1
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	KLF6, SFRP2, VEGFA, VDR, , MYCN
48	cell cycle arrest	GO:007050	INF	NBN, , MSH2, CDK6, CDKN2B, CDKN2A
49	canonical Wnt receptor signaling pathway	GO:060070	INF	, LEF1, AXIN1, FZD1, FZD2, FZD3
50	branching involved in ureteric bud morphogenesis	GO:001658	INF	, BMP2, BMP4, BCL2, LAMA5, CD44

Molecular functions related to basal cell carcinoma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	structural molecule activity	GO:005198	11.5	KRT8, KRT7, KRT86, KRT10, KRT18, KRT38
2	frizzled binding	GO:005109	11.4	WNT3, WNT4, WNT5A, WNT8A, WNT2, WNT1
3	structural constituent of cytoskeleton	GO:005200	11.1	KRT14, KRT19, KRT20, KRT15, KRT17, KRT31
4	Wnt-protein binding	GO:017147	11.1	ROR2, FZD9, FZD7, FZD6, FZD5, FZD3
5	Wnt-activated receptor activity	GO:042813	11.0	FZD8, FZD6, FZD5, FZD4, FZD3, FZD1
6	beta-catenin binding	GO:008013	10.9	GLI3, TRPC4, SUFU, DVL3, TCF7L2, SOX9
7	integrin binding	GO:005178	10.9	GFAP, TIMP2, DST, ADAM10, ADAM17, ILK
8	receptor binding	GO:005102	10.9	NOS2, LTA, DVL3, TGFB2, TDGF1, CXCL12
9	receptor agonist activity	GO:048018	10.8	WNT4, WNT5A, WNT7A, WNT8A, WNT3A, WNT3
10	protein kinase binding	GO:019901	10.3	PTEN, TP53, HSPB1, CCND1, SUFU, CYLD
11	transcription regulatory region DNA binding	GO:044212	10.0	TCF7, TCF7L2, STAT3, WNT1, WNT11, WNT5A
12	protein homodimerization activity	GO:042803	9.3	TERT, HLA-G, HNF1B, CCL5, FAP, GSTM3
13	cytokine activity	GO:005125	8.9	TNF, TNFSF8, LTA, EDN1, TGFB2, WNT1
14	enzyme binding	GO:019899	8.7	CTNNB1, PPARG, NOTCH1, NOTCH3, EGFR, DVL1
15	growth factor activity	GO:008083	8.3	IL6, EGF, HBEGF, TYMP, TGFA, TGFB1
16	protein heterodimerization activity	GO:046982	INF	ERBB2, HNF1B, CAPN2, MCL1, ITGB1, TP53
17	transcription factor binding	GO:008134	INF	SUFU, CTNNB1, PPP1R13L, CREBBP, TCF7L2, STAT3
18	protein binding	GO:005515	INF	KRT8, SMO, PPARG, PPP1R13L, CTSB, CTNNB1