MCID: BSL007
MIFTS: 66

Basal Cell Carcinoma malady

Genetic diseases, Skin diseases, Cancer diseases, Rare diseases categories

Summaries for Basal Cell Carcinoma

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Wikipedia:65 Basal-cell carcinoma or basal cell cancer (BCC), a skin cancer, is one of the most common cancers in the... more...

MalaCards based summary: Basal Cell Carcinoma, also known as basal cell cancer, is related to nodular basal cell carcinoma and basal cell nevus syndrome. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Glypican 3 network and Aurora A signaling. The drug fluorouracil and the compounds 20(s)-hydroxycholesterol and ciliobrevin a have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and bone, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:10 A skin carcinoma affecting basal cells.

Aliases & Classifications for Basal Cell Carcinoma

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Sources:
10Disease Ontology, 12DISEASES, 62UMLS, 45Novoseek, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Basal Cell Carcinoma, Aliases & Descriptions:

Name: Basal Cell Carcinoma 10 12 62
Basal Cell Cancer 10 45 62
Malignant Basal Cell Neoplasm 10 62
Basal Cell Carcinoma of Skin 10 62
Malignant Basal Cell Tumor 10 62
Epithelioma Basal Cell 10 62
 
Basal Cell Neoplasm 10 62
Basal Cell Carcinoma Nos 10
Basal Cell Neoplasm Nos 10
Carcinoma Basal Cell 45
Basal Cell Tumor 10
Rodent Ulcer 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Skin diseases


Related Diseases for Basal Cell Carcinoma

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Diseases in the Large Cell Carcinoma family:

Basal Cell Carcinoma 7 Small Cell Carcinoma
basal cell carcinoma Cell Type Benign Neoplasm
Cell Type Cancer Basal Cell Carcinoma, Multiple

Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1nodular basal cell carcinoma31.5KRT38, KRT31
2basal cell nevus syndrome31.1SMO, SHH, PTCH2, PTCH1, OR10X1, ROR2
3medulloblastoma31.0SMO, SHH, PTCH2, PTCH1, TP53, GLI1
4basal cell carcinoma, somatic30.9RASA1, PTCH1, PTCH2
5basal cell carcinoma, multiple30.8PTCH1, CYP1A1
6ameloblastoma30.5GLI1, PTCH1
7xeroderma pigmentosum, variant type30.4CYP1A1, PTCH1, TP53
8pancreatic cancer30.1SMO, SHH, PTCH1, TP53, GLI1
9superficial basal cell carcinoma11.1
10pigmented basal cell carcinoma11.0
11keratosis10.9
12melanoma10.9
13actinic keratosis10.8
14infundibulocystic basal cell carcinoma10.7
15infiltrative basal cell carcinoma10.7
16morpheaform basal cell carcinoma10.7
17cystic basal cell carcinoma10.7
18adenoiditis10.7
19clear cell basal cell carcinoma10.7
20adenoid basal cell carcinoma10.6
21metatypical basal cell carcinoma10.6
22sarcomatoid basal cell carcinoma10.6
23keratoacanthoma10.6
24micronodular basal cell carcinoma10.6
25prostatitis10.6
26bazex syndrome10.5
27burn scar10.5
28burns10.5
29psoriasis10.5
30basaloid follicular hamartoma10.5
31breast cancer10.5
32syringocystadenoma papilliferum10.5
33rombo syndrome10.5
34blindness10.5
35brooke-spiegler syndrome10.4
36fibroma10.4
37anal margin basal cell carcinoma10.4
38external ear basal cell carcinoma10.4
39scrotum basal cell carcinoma10.4
40vulva basal cell carcinoma10.4
41merkel cell carcinoma10.4
42hypotrichosis10.4
43basal cell carcinoma 710.4
44myelophthisic anemia10.4
45basaloid squamous cell carcinoma10.4
46follicular basal cell carcinoma10.4
47fibroepithelial basal cell carcinoma10.4
48signet ring basal cell carcinoma10.4
49myiasis10.4
50tinea capitis10.4

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Symptoms for Basal Cell Carcinoma

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Drugs & Therapeutics for Basal Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Basal Cell Carcinoma

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Anatomical Context for Basal Cell Carcinoma

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MalaCards organs/tissues related to Basal Cell Carcinoma:

33
Skin, Prostate, Bone, Breast, Smooth muscle, Lung, T cells, Eye, Bone marrow, Thyroid, Testes, Endothelial, Lymph node, Brain, Heart, Salivary gland, Ovary, Uterus, Testis, Cervix, Trachea

Animal Models for Basal Cell Carcinoma or affiliated genes

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Publications for Basal Cell Carcinoma

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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1547)
idTitleAuthorsYear
1
Treatment of superficial basal cell carcinoma and squamous cell carcinoma in situ on the trunk and extremities with ablative fractional laser-assisted delivery of topical fluorouracil. (25687314)
2015
2
Conservative treatment protocol of keratocystic odontogenic tumor: report of a case with nevoid Basal cell carcinoma syndrome and literature review. (25848161)
2015
3
Invasive basal cell carcinoma in a xeroderma pigmentosum patient: facing secondary and tertiary aggressive recurrences. (24978686)
2014
4
Narrow-margin excision is a safe, reliable treatment for well-defined, primary pigmented basal cell carcinoma: an analysis of 288 lesions in Japan. (25186070)
2014
5
Cytokeratin 20 expression in basaloid follicular hamartoma and infundibulocystic basal cell carcinoma. (25353070)
2014
6
Basal cell carcinoma margin delineation: is curettage useful? A surgical and histological study. (23216407)
2013
7
Regional variations of basal cell carcinoma incidence in the U.K. using The Health Improvement Network database (2004-10). (23701520)
2013
8
Pigmented Basal cell carcinoma: a clinical variant, report of two cases. (24551712)
2013
9
Mushroom-Like Giant Basal Cell Carcinoma on the Nasal Tip. (24372940)
2013
10
Clinical and radiological features in young individuals with nevoid basal cell carcinoma syndrome. (22918513)
2013
11
Epidemiology of basal cell carcinoma in Lithuania, 1996-2010. (23795568)
2013
12
Vismodegib (Erivedge) for basal cell carcinoma. (22777303)
2012
13
Splicing aberration in naevoid basal cell carcinoma syndrome. (22434048)
2012
14
Basal cell carcinoma of the scrotum with a lesion of 51 years' duration. (22171695)
2012
15
Risk factors for orbital exenteration in periocular basal cell carcinoma. (22709845)
2012
16
Adamantinoid basal cell carcinoma: a predictor of more-aggressive clinical behavior. (22551358)
2012
17
Treatment of nodular basal cell carcinoma with cryotherapy and reduced protocol of imiquimod. (23270198)
2012
18
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. (21430703)
2011
19
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
20
GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma. (21577203)
2011
21
Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream. (18789101)
2008
22
Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (18789069)
2008
23
Mutations of microsatellite instability target genes in sporadic basal cell carcinomas. (17950544)
2007
24
Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. (17638732)
2007
25
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
26
Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma. (17875873)
2007
27
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. (16582078)
2006
28
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
29
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
30
Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma. (12692363)
2003
31
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
32
Shadow cell basal cell carcinoma with acantholysis. (11829183)
2002
33
Sub-populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation. (11168750)
2001
34
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. (11174390)
2001
35
Activation of expression of hedgehog target genes in basal cell carcinomas. (11348463)
2001
36
Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome. (11457640)
2001
37
Low levels of urokinase plasminogen activator components in basal cell carcinoma of the skin. (10699914)
2000
38
Basal cell carcinoma with tumor epithelial and stromal giant cells: a variant of pleomorphic basal cell carcinoma. (10535579)
1999
39
Immunohistochemical characterization of pleomorphic giant cells in basal cell carcinoma. (10487292)
1999
40
Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. (9256917)
1997
41
Molecular basis of the nevoid basal cell carcinoma syndrome. (9425597)
1997
42
bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. (8043419)
1994
43
Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection. (7962742)
1994
44
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
45
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma. (1342967)
1992
46
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. (1469302)
1992
47
Possibilities for application of radioimmunological analysis of CEA, AFP, SP1 and ferritin in patients with basal cell carcinoma of the eyelids. (1726640)
1991
48
Severe irritant dermatitis mimicking a basal cell carcinoma. (6230178)
1983
49
The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. (6177160)
1981
50
Superficial Basal-cell Carcinoma. (19992640)
1943

Variations for Basal Cell Carcinoma

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Cosmic variations for Basal Cell Carcinoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144925TP53skin,NS,carcinoma,basal cell carcinoma3
244310TP53skin,NS,carcinoma,basal cell carcinoma3
343842TP53skin,NS,carcinoma,basal cell carcinoma3
410660TP53skin,NS,carcinoma,basal cell carcinoma3
544167TP53skin,NS,carcinoma,basal cell carcinoma3
643665TP53skin,NS,carcinoma,basal cell carcinoma3
744071TP53skin,NS,carcinoma,basal cell carcinoma3
843702TP53skin,NS,carcinoma,basal cell carcinoma3
910771TP53skin,NS,carcinoma,basal cell carcinoma3
1045015TP53skin,NS,carcinoma,basal cell carcinoma3
1110704TP53skin,NS,carcinoma,basal cell carcinoma3
1245740TP53skin,NS,carcinoma,basal cell carcinoma3
1344074TP53skin,NS,carcinoma,basal cell carcinoma3
1444096TP53skin,NS,carcinoma,basal cell carcinoma3
1544606TP53skin,NS,carcinoma,basal cell carcinoma3
1643608TP53skin,NS,carcinoma,basal cell carcinoma3
1743616TP53skin,NS,carcinoma,basal cell carcinoma3
1843635TP53skin,NS,carcinoma,basal cell carcinoma3
1910648TP53skin,NS,carcinoma,basal cell carcinoma3
2043700TP53skin,NS,carcinoma,basal cell carcinoma3
2143585TP53skin,NS,carcinoma,basal cell carcinoma3
2243592TP53skin,NS,carcinoma,basal cell carcinoma3
2343577TP53skin,NS,carcinoma,basal cell carcinoma3
2410812TP53skin,NS,carcinoma,basal cell carcinoma3
2510656TP53skin,NS,carcinoma,basal cell carcinoma3
2645420TP53skin,NS,carcinoma,basal cell carcinoma3
2744226TP53skin,NS,carcinoma,basal cell carcinoma3
2810768TP53skin,NS,carcinoma,basal cell carcinoma3
2944603TP53skin,NS,carcinoma,basal cell carcinoma3
306932TP53skin,NS,carcinoma,basal cell carcinoma3
3143582TP53skin,NS,carcinoma,basal cell carcinoma3
3210659TP53skin,NS,carcinoma,basal cell carcinoma3
3343584TP53skin,NS,carcinoma,basal cell carcinoma3
3445739TP53skin,NS,carcinoma,basal cell carcinoma3
3543581TP53skin,NS,carcinoma,basal cell carcinoma3
3645423TP53skin,NS,carcinoma,basal cell carcinoma3
3744097TP53skin,NS,carcinoma,basal cell carcinoma3
3810988TP53skin,NS,carcinoma,basal cell carcinoma3
3944068TP53skin,NS,carcinoma,basal cell carcinoma3
406549TP53skin,NS,carcinoma,basal cell carcinoma3
4110749TP53skin,NS,carcinoma,basal cell carcinoma3
4245424TP53skin,NS,carcinoma,basal cell carcinoma3
4310662TP53skin,NS,carcinoma,basal cell carcinoma3
4410794TP53skin,NS,carcinoma,basal cell carcinoma3
4543837TP53skin,NS,carcinoma,basal cell carcinoma3
4610650TP53skin,NS,carcinoma,basal cell carcinoma3
4710867TP53skin,NS,carcinoma,basal cell carcinoma3
4896963PTCH1skin,NS,carcinoma,basal cell carcinoma3
4924851PTCH1skin,NS,carcinoma,basal cell carcinoma3
5029349PTCH1skin,NS,carcinoma,basal cell carcinoma3
5117547PTCH1skin,NS,carcinoma,basal cell carcinoma3
5217454PTCH1skin,NS,carcinoma,basal cell carcinoma3
5317434PTCH1skin,NS,carcinoma,basal cell carcinoma3
5429348PTCH1skin,NS,carcinoma,basal cell carcinoma3
5517481PTCH1skin,NS,carcinoma,basal cell carcinoma3
5617592PTCH1skin,NS,carcinoma,basal cell carcinoma3
5796960PTCH1skin,NS,carcinoma,basal cell carcinoma3
5896959PTCH1skin,NS,carcinoma,basal cell carcinoma3
5926361PTCH1skin,NS,carcinoma,basal cell carcinoma3
6096957PTCH1skin,NS,carcinoma,basal cell carcinoma3
6196958PTCH1skin,NS,carcinoma,basal cell carcinoma3
6226365PTCH1skin,NS,carcinoma,basal cell carcinoma3
631651688PTCH1skin,NS,carcinoma,basal cell carcinoma3
6426372PTCH1skin,NS,carcinoma,basal cell carcinoma3
65483HRASskin,NS,carcinoma,basal cell carcinoma3
66490HRASskin,NS,carcinoma,basal cell carcinoma3
67486HRASskin,NS,carcinoma,basal cell carcinoma3
6812476CDKN2Askin,NS,carcinoma,basal cell carcinoma3
695662CTNNB1skin,NS,carcinoma,basal cell carcinoma3
70553KRASskin,NS,carcinoma,basal cell carcinoma3
7113146SMOskin,NS,carcinoma,basal cell carcinoma3

Expression for genes affiliated with Basal Cell Carcinoma

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Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

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Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PTCH1, SHH
210.0TP53, RASA1
39.6SHH, PTCH2, PTCH1, GLI1
49.5TP53, SHH, SMO
59.5TP53, PTCH1, SMO
6
Show member pathways
9.3SMO, SHH, PTCH2, PTCH1
79.3SMO, SHH, PTCH1, GLI1
89.3GLI1, PTCH1, SHH, SMO
9
Show member pathways
9.2GAS1, ROR2, PTCH2, SMO
109.1SMO, SHH, PTCH2, PTCH1, GAS1
11
Show member pathways
8.9GAS1, GLI1, PTCH1, PTCH2, SHH, SMO
128.9SMO, SHH, PTCH2, PTCH1, TP53, GLI1
13
Show member pathways
8.7SMO, PTCH2, TP53, ROR2, RASA1, GAS1
14
Show member pathways
8.6SMO, SHH, PTCH2, PTCH1, TP53, GLI1
15
Show member pathways
8.2SMO, SHH, PTCH2, PTCH1, TP53, OR10X1

Compounds for genes affiliated with Basal Cell Carcinoma

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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
120(s)-hydroxycholesterol6110.2SHH, GLI1
2ciliobrevin a6110.2SHH, GLI1
3sant-16110.2SHH, GLI1
4ay 9944 dihydrochloride6110.1SHH, GLI1
5ellipticine4510.0TP53, CYP1A1
6bpde4510.0TP53, CYP1A1
73,3-diindolylmethane459.9TP53, CYP1A1
8aristolochic acid45 310.7TP53, CYP1A1
9cyclopamine45 6110.5GLI1, PTCH1, SHH, SMO

GO Terms for genes affiliated with Basal Cell Carcinoma

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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:00723729.5GLI1, PTCH1, SMO

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1ventral midline developmentGO:000741810.4SHH, GLI1
2spinal cord motor neuron differentiationGO:002152210.3SHH, PTCH1
3dorsal/ventral pattern formationGO:000995310.2SHH, PTCH1, GLI1
4negative regulation of smoothened signaling pathwayGO:004587910.2GAS1, PTCH1, PTCH2
5regulation of smoothened signaling pathwayGO:000858910.2PTCH1, GLI1, GAS1
6camera-type eye developmentGO:004301010.2GAS1, SHH, CYP1A1
7negative regulation of canonical Wnt signaling pathwayGO:009009010.1GLI1, ROR2, SHH
8positive regulation of hh target transcription factor activityGO:000722810.1SMO, SHH
9determination of left/right asymmetry in lateral mesodermGO:000314010.1SMO, SHH
10response to antibioticGO:004667710.1CYP1A1, TP53
11cerebellar cortex morphogenesisGO:002169610.1GLI1, SMO
12epidermis developmentGO:000854410.1PTCH2, PTCH1, KRT31
13thalamus developmentGO:002179410.1SMO, SHH
14mammary gland epithelial cell differentiationGO:006064410.1SMO, PTCH1
15cellular response to cholesterolGO:007139710.0PTCH1, SMO
16positive regulation of protein import into nucleusGO:004230710.0SHH, SMO
17cell fate specificationGO:000170810.0SMO, SHH
18neuron fate commitmentGO:004866310.0SMO, SHH
19T cell differentiation in thymusGO:003307710.0TP53, SHH
20positive regulation of neuroblast proliferationGO:000205210.0SMO, SHH
21embryonic digestive tract morphogenesisGO:004855710.0SHH, SMO
22smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:002193810.0GLI1, SHH, SMO
23protein localization to nucleusGO:00345049.9SHH, SMO
24somite developmentGO:00610539.9PTCH1, SHH, SMO
25somitogenesisGO:00017569.9ROR2, TP53
26renal system developmentGO:00720019.9SMO, SHH, PTCH1
27hair follicle morphogenesisGO:00310699.9SHH, SMO
28dorsal/ventral neural tube patterningGO:00219049.9GAS1, SHH, SMO
29vasculogenesisGO:00015709.9RASA1, SHH, SMO
30heart morphogenesisGO:00030079.8SMO, PTCH1
31positive regulation of transcription, DNA-templatedGO:00458939.7SHH, TP53, ROR2, GLI1
32smoothened signaling pathwayGO:00072249.7SMO, SHH, PTCH1, GLI1
33positive regulation of smoothened signaling pathwayGO:00458809.7GAS1, GLI1, SHH, SMO
34positive regulation of mesenchymal cell proliferationGO:00020539.6SMO, GAS1
35neural crest cell migrationGO:00017559.4SHH, SMO
36negative regulation of transcription from RNA polymerase II promoterGO:00001229.3SMO, SHH, PTCH1, TP53

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hedgehog family protein bindingGO:009710810.1PTCH2, PTCH1
2smoothened bindingGO:000511910.0PTCH2, PTCH1
3hedgehog receptor activityGO:00081589.8PTCH1, PTCH2
4Wnt-protein bindingGO:00171479.7ROR2, SMO
5patched bindingGO:00051139.6PTCH1, SHH, SMO

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet