MCID: BSL007
MIFTS: 63

Basal Cell Carcinoma malady

Cancer diseases, Skin diseases, Rare diseases categories
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Summaries for Basal Cell Carcinoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Basal-cell carcinoma or basal cell cancer (BCC), a skin cancer, is the most common cancer. It rarely... more...

MalaCards: Basal Cell Carcinoma, also known as basal cell cancer, is related to nevoid basal cell carcinoma syndrome and nodular basal cell carcinoma. An important gene associated with Basal Cell Carcinoma is PTCH2 (patched 2), and among its related pathways are Glypican 3 network and Aurora A signaling. The drug fluorouracil and the compounds 20(s)-hydroxycholesterol and ciliobrevin a have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and bone, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Basal Cell Carcinoma

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8Disease Ontology, 10DISEASES, 62UMLS, 45Novoseek, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

basal cell carcinoma 8 10 62
basal cell cancer 8 45 62
malignant basal cell tumor 8 62
basal cell neoplasm 8 62
malignant basal cell neoplasm 8
basal cell carcinoma of skin 8
basal cell carcinoma nos 8
basal cell neoplasm nos 8
epithelioma basal cell 8
carcinoma basal cell 45
basal cell tumor 8
rodent ulcer 8


Related Diseases for Basal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Basal Cell Carcinoma family:

Large Cell Carcinoma Small Cell Carcinoma
Cell Type Benign Neoplasm Cell Type Cancer
Basal Cell Carcinoma, Multiple Basal Cell Carcinoma 1
Basal Cell Carcinoma 2 Basal Cell Carcinoma 3
Basal Cell Carcinoma 6 Basal Cell Carcinoma 5
Basal Cell Carcinoma 4 Basal Cell Carcinoma 7

Diseases related to Basal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1nevoid basal cell carcinoma syndrome31.8SMO, SHH, PTCH2, PTCH1, OR10X1, ROR2
2nodular basal cell carcinoma31.5KRT38, KRT31
3xeroderma pigmentosum31.0CYP1A1, PTCH1, TP53
4medulloblastoma30.9SMO, SHH, PTCH2, PTCH1, TP53, GLI1
5basal cell carcinoma, somatic30.8RASA1, PTCH1, PTCH2
6basal cell carcinoma, multiple30.8PTCH1, CYP1A1
7pancreatic cancer30.1SMO, SHH, PTCH1, TP53, GLI1
8superficial basal cell carcinoma11.1
9pigmented basal cell carcinoma10.9
10keratosis10.9
11melanoma10.9
12actinic keratosis10.8
13infiltrative basal cell carcinoma10.7
14seborrheic keratosis10.7
15morpheaform basal cell carcinoma10.7
16infundibulocystic basal cell carcinoma10.7
17clear cell basal cell carcinoma10.6
18cystic basal cell carcinoma10.6
19adenoiditis10.6
20adenoid basal cell carcinoma10.6
21sarcomatoid basal cell carcinoma10.6
22keratoacanthoma10.6
23metatypical basal cell carcinoma10.5
24micronodular basal cell carcinoma10.5
25burn scar10.5
26burns10.5
27prostatitis10.5
28psoriasis10.5
29syringocystadenoma papilliferum10.5
30breast cancer10.5
31meningioma10.5
32basaloid follicular hamartoma10.5
33fibroma10.4
34brooke-spiegler syndrome10.4
35merkel cell carcinoma10.4
36hypotrichosis10.4
37bazex-dupre-christol syndrome10.4
38rombo syndrome10.4
39cutaneous malignant melanoma10.4
40myelophthisic anemia10.4
41anal margin basal cell carcinoma10.4
42external ear basal cell carcinoma10.4
43follicular basal cell carcinoma10.4
44scrotum basal cell carcinoma10.4
45signet ring basal cell carcinoma10.4
46vulva basal cell carcinoma10.4
47vitiligo10.4
48myiasis10.4
49tinea capitis10.4
50molluscum contagiosum10.3

Graphical network of the top 20 diseases related to Basal Cell Carcinoma:



Diseases related to basal cell carcinoma

Symptoms for Basal Cell Carcinoma

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Drugs & Therapeutics for Basal Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Basal Cell Carcinoma

Search NIH Clinical Center for Basal Cell Carcinoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Basal Cell Carcinoma

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Anatomical Context for Basal Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Basal Cell Carcinoma:

33
Skin, Prostate, Bone, T cells, Breast, Smooth muscle, Lung, Eye, Thyroid, Testes, Bone marrow, Endothelial, Brain, Lymph node, Testis, Salivary gland, Trachea, Ovary, Uterus, Cervix

Animal Models for Basal Cell Carcinoma or affiliated genes

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37MGI
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Publications for Basal Cell Carcinoma

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52PubMed
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Articles related to Basal Cell Carcinoma:

(show top 50)    (show all 1455)
idTitleAuthorsYear
1
Case of the month. Multiple odontogenic keratocysts in association with nevoid basal cell carcinoma syndrome (NBCCS). (24400412)
2013
2
Basal cell carcinoma margin delineation: is curettage useful? A surgical and histological study. (23216407)
2013
3
Regional variations of basal cell carcinoma incidence in the U.K. using The Health Improvement Network database (2004-10). (23701520)
2013
4
Mushroom-Like Giant Basal Cell Carcinoma on the Nasal Tip. (24372940)
2013
5
Clinical and radiological features in young individuals with nevoid basal cell carcinoma syndrome. (22918513)
2013
6
Epidemiology of basal cell carcinoma in Lithuania, 1996-2010. (23795568)
2013
7
Vismodegib (Erivedge) for basal cell carcinoma. (22777303)
2012
8
Splicing aberration in naevoid basal cell carcinoma syndrome. (22434048)
2012
9
Basal cell carcinoma of the scrotum with a lesion of 51 years' duration. (22171695)
2012
10
Risk factors for orbital exenteration in periocular basal cell carcinoma. (22709845)
2012
11
Adamantinoid basal cell carcinoma: a predictor of more-aggressive clinical behavior. (22551358)
2012
12
Treatment of nodular basal cell carcinoma with cryotherapy and reduced protocol of imiquimod. (23270198)
2012
13
Basal cell carcinoma of the prostate: a case report. (22656427)
2012
14
Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. (21430703)
2011
15
Basal cell carcinoma, syringocystadenoma papilliferum, trichilemmoma, and sebaceoma arising within a nevus sebaceus associated with pigmented nevi. (22093024)
2011
16
GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma. (21577203)
2011
17
Multiple basal cell carcinomas in xeroderma pigmentosum treated with imiquimod 5% cream. (18789101)
2008
18
Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (18789069)
2008
19
Mutations of microsatellite instability target genes in sporadic basal cell carcinomas. (17950544)
2007
20
Dendritic cells in pigmented basal cell carcinoma: a relevant finding by reflectance-mode confocal microscopy. (17638732)
2007
21
The Delphi panel in the economic evaluation of photodynamic therapy for actinic keratosis and basal cell carcinoma: poor results? (17535242)
2007
22
Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs surgery for nodular basal cell carcinoma. (17875873)
2007
23
Influence of glutathione-S-transferase (GSTM1, GSTP1, GSTT1) and cytochrome p450 (CYP1A1, CYP2D6) polymorphisms on numbers of basal cell carcinomas (BCCs) in families with the naevoid basal cell carcinoma syndrome. (16582078)
2006
24
A collision tumor involving Basal cell carcinoma and lentigo maligna melanoma. (16121053)
2005
25
5% imiquimod cream for the treatment of large superficial basal cell carcinoma. (15492202)
2004
26
Cutaneous undifferentiated small (Merkel) cell carcinoma, that developed synchronously with multiple actinic keratoses, squamous cell carcinomas and basal cell carcinoma. (12692363)
2003
27
Syringocystadenoma papilliferum mimicking basal cell carcinoma on the lower eyelid: a case report. (12661924)
2002
28
Shadow cell basal cell carcinoma with acantholysis. (11829183)
2002
29
Sub-populations of melanocytes in pigmented basal cell carcinoma: a quantitative, ultrastructural investigation. (11168750)
2001
30
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin. (11174390)
2001
31
Activation of expression of hedgehog target genes in basal cell carcinomas. (11348463)
2001
32
Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome. (11457640)
2001
33
Low levels of urokinase plasminogen activator components in basal cell carcinoma of the skin. (10699914)
2000
34
Basal cell carcinoma with tumor epithelial and stromal giant cells: a variant of pleomorphic basal cell carcinoma. (10535579)
1999
35
Immunohistochemical characterization of pleomorphic giant cells in basal cell carcinoma. (10487292)
1999
36
The measurement of constitutive and facultative skin pigmentation and estimation of sun exposure in Caucasians with basal cell carcinoma and cutaneous malignant melanoma. (9892904)
1998
37
Transforming growth factor-beta and bcl-2 distribution patterns distinguish trichoepithelioma from basal cell carcinoma. (9256917)
1997
38
Molecular basis of the nevoid basal cell carcinoma syndrome. (9425597)
1997
39
bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. (8043419)
1994
40
Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection. (7962742)
1994
41
Basal cell carcinoma and keratoacanthoma in Hawaiians: an incidence report. (8227552)
1993
42
Clear cell basal cell carcinoma: an unusual degenerative variant. (8227606)
1993
43
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma. (1342967)
1992
44
Breast-cancer-associated stromelysin-3 gene is expressed in basal cell carcinoma and during cutaneous wound healing. (1469302)
1992
45
Possibilities for application of radioimmunological analysis of CEA, AFP, SP1 and ferritin in patients with basal cell carcinoma of the eyelids. (1726640)
1991
46
Severe irritant dermatitis mimicking a basal cell carcinoma. (6230178)
1983
47
Adenoid basal cell carcinoma of the vulva. (7185765)
1982
48
The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis. (6177160)
1981
49
Pigmented basal-cell carcinoma in verrucous nevi. Report of 2 cases. (13785794)
1961
50
Superficial Basal-cell Carcinoma. (19992640)
1943

Variations for Basal Cell Carcinoma

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Expression for genes affiliated with Basal Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Basal Cell Carcinoma

Search GEO for disease gene expression data for Basal Cell Carcinoma.

Pathways for genes affiliated with Basal Cell Carcinoma

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50PathCards, 38NCBI BioSystems Database, 5Cell Signaling Technology, 30KEGG, 55Reactome, 60Thomson Reuters, 53QIAGEN, 51PharmGKB, 61Tocris Bioscience
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Pathways related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PTCH1, SHH
210.0TP53, RASA1
39.6SHH, PTCH2, PTCH1, GLI1
49.5TP53, SHH, SMO
59.5TP53, PTCH1, SMO
6
Show member pathways
9.3SMO, SHH, PTCH2, PTCH1
79.3SMO, SHH, PTCH1, GLI1
89.3GLI1, PTCH1, SHH, SMO
9
Show member pathways
9.2GAS1, ROR2, PTCH2, SMO
109.1SMO, SHH, PTCH2, PTCH1, GAS1
11
Show member pathways
8.9GAS1, GLI1, PTCH1, PTCH2, SHH, SMO
128.9SMO, SHH, PTCH2, PTCH1, TP53, GLI1
13
Show member pathways
8.7SMO, PTCH2, TP53, ROR2, RASA1, GAS1
14
Show member pathways
8.6SMO, SHH, PTCH2, PTCH1, TP53, GLI1
15
Show member pathways
8.2SMO, SHH, PTCH2, PTCH1, TP53, OR10X1

Compounds for genes affiliated with Basal Cell Carcinoma

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61Tocris Bioscience, 45Novoseek, 3BitterDB
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Compounds related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
120(s)-hydroxycholesterol6110.2SHH, GLI1
2ciliobrevin a6110.2SHH, GLI1
3sant-16110.2SHH, GLI1
4ay 9944 dihydrochloride6110.1SHH, GLI1
5ellipticine4510.0TP53, CYP1A1
6bpde4510.0TP53, CYP1A1
73,3-diindolylmethane459.9TP53, CYP1A1
8aristolochic acid45 310.7TP53, CYP1A1
9cyclopamine45 6110.5GLI1, PTCH1, SHH, SMO

GO Terms for genes affiliated with Basal Cell Carcinoma

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16Gene Ontology
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Cellular components related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary ciliumGO:0723729.5GLI1, PTCH1, SMO

Biological processes related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1ventral midline developmentGO:00741810.4SHH, GLI1
2spinal cord motor neuron differentiationGO:02152210.3SHH, PTCH1
3dorsal/ventral pattern formationGO:00995310.2SHH, PTCH1, GLI1
4negative regulation of smoothened signaling pathwayGO:04587910.2GAS1, PTCH1, PTCH2
5regulation of smoothened signaling pathwayGO:00858910.2PTCH1, GLI1, GAS1
6camera-type eye developmentGO:04301010.2GAS1, SHH, CYP1A1
7negative regulation of canonical Wnt signaling pathwayGO:09009010.1GLI1, ROR2, SHH
8positive regulation of hh target transcription factor activityGO:00722810.1SMO, SHH
9determination of left/right asymmetry in lateral mesodermGO:00314010.1SMO, SHH
10response to antibioticGO:04667710.1CYP1A1, TP53
11cerebellar cortex morphogenesisGO:02169610.1GLI1, SMO
12epidermis developmentGO:00854410.1PTCH2, PTCH1, KRT31
13thalamus developmentGO:02179410.1SMO, SHH
14mammary gland epithelial cell differentiationGO:06064410.1SMO, PTCH1
15cellular response to cholesterolGO:07139710.0PTCH1, SMO
16positive regulation of protein import into nucleusGO:04230710.0SHH, SMO
17cell fate specificationGO:00170810.0SMO, SHH
18neuron fate commitmentGO:04866310.0SMO, SHH
19T cell differentiation in thymusGO:03307710.0TP53, SHH
20positive regulation of neuroblast proliferationGO:00205210.0SMO, SHH
21embryonic digestive tract morphogenesisGO:04855710.0SHH, SMO
22smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationGO:02193810.0GLI1, SHH, SMO
23protein localization to nucleusGO:0345049.9SHH, SMO
24somite developmentGO:0610539.9PTCH1, SHH, SMO
25somitogenesisGO:0017569.9ROR2, TP53
26renal system developmentGO:0720019.9SMO, SHH, PTCH1
27hair follicle morphogenesisGO:0310699.9SHH, SMO
28dorsal/ventral neural tube patterningGO:0219049.9GAS1, SHH, SMO
29vasculogenesisGO:0015709.9RASA1, SHH, SMO
30heart morphogenesisGO:0030079.8SMO, PTCH1
31positive regulation of transcription, DNA-templatedGO:0458939.7SHH, TP53, ROR2, GLI1
32smoothened signaling pathwayGO:0072249.7SMO, SHH, PTCH1, GLI1
33positive regulation of smoothened signaling pathwayGO:0458809.7GAS1, GLI1, SHH, SMO
34positive regulation of mesenchymal cell proliferationGO:0020539.6SMO, GAS1
35neural crest cell migrationGO:0017559.4SHH, SMO
36negative regulation of transcription from RNA polymerase II promoterGO:0001229.3SMO, SHH, PTCH1, TP53

Molecular functions related to Basal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hedgehog family protein bindingGO:09710810.1PTCH2, PTCH1
2smoothened bindingGO:00511910.0PTCH2, PTCH1
3hedgehog receptor activityGO:0081589.8PTCH1, PTCH2
4Wnt-protein bindingGO:0171479.7ROR2, SMO
5patched bindingGO:0051139.6PTCH1, SHH, SMO

Products for genes affiliated with Basal Cell Carcinoma

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Sources for Basal Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet