MCID: BSL011
MIFTS: 25

Basal Cell Carcinoma, Multiple malady

Categories: Rare diseases, Cancer diseases, Genetic diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Basal Cell Carcinoma, Multiple

Aliases & Descriptions for Basal Cell Carcinoma, Multiple:

Name: Basal Cell Carcinoma, Multiple 50 52 69
Multiple Basal Cell Carcinoma 50 29

Classifications:



Summaries for Basal Cell Carcinoma, Multiple

MalaCards based summary : Basal Cell Carcinoma, Multiple, also known as multiple basal cell carcinoma, is related to basal cell carcinoma 1 and basal cell carcinoma. An important gene associated with Basal Cell Carcinoma, Multiple is PTCH1 (Patched 1), and among its related pathways/superpathways is Wnt / Hedgehog / Notch. The drugs Aminolevulinic acid and Imiquimod have been mentioned in the context of this disorder. Related phenotype is growth/size/body region.

Related Diseases for Basal Cell Carcinoma, Multiple

Graphical network of the top 20 diseases related to Basal Cell Carcinoma, Multiple:



Diseases related to Basal Cell Carcinoma, Multiple

Symptoms & Phenotypes for Basal Cell Carcinoma, Multiple

MGI Mouse Phenotypes related to Basal Cell Carcinoma, Multiple:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 8.92 CYLD CYP1A1 PTCH1 SLC45A2

Drugs & Therapeutics for Basal Cell Carcinoma, Multiple

Drugs for Basal Cell Carcinoma, Multiple (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aminolevulinic acid Approved Phase 3,Phase 2 106-60-5 137
2
Imiquimod Approved, Investigational Phase 3 99011-02-6 57469
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
4
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6
Verteporfin Approved, Investigational Phase 3 129497-78-5
7 pancreatic polypeptide Phase 3
8 interferons Phase 3,Phase 1,Phase 2
9 Analgesics Phase 3,Phase 2
10 Adjuvants, Anesthesia Phase 3
11 Adjuvants, Immunologic Phase 3
12 Narcotics Phase 3
13 Dermatologic Agents Phase 3,Phase 2,Phase 1
14 Analgesics, Opioid Phase 3
15 Anesthetics Phase 3
16 Anesthetics, General Phase 3
17 Anesthetics, Intravenous Phase 3
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Photosensitizing Agents Phase 3,Phase 2,Phase 1
20 Interferon Inducers Phase 3
21 Liver Extracts Phase 3,Phase 1
22 Methyl 5-aminolevulinate Phase 3
23 Antimitotic Agents Phase 3,Phase 1
24 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
25 Central Nervous System Depressants Phase 3
26 taxane Phase 3
27 Albumin-Bound Paclitaxel Phase 3
28 Cola Nutraceutical Phase 3,Phase 1
29 Tea Nutraceutical Phase 2, Phase 3
30
Simvastatin Approved Phase 2 79902-63-9 54454
31
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
32
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
33
Diclofenac Approved, Vet_approved Phase 2 15307-86-5 3033
34
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
35
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
36
Tazarotene Approved, Investigational Phase 2 118292-40-3 5381
37
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
38
Fluorouracil Approved Phase 1, Phase 2 51-21-8 3385
39
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
40
Calcitriol Approved, Nutraceutical Phase 2 32222-06-3 134070 5280453
41
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
42
Cholecalciferol Approved, Nutraceutical Phase 2 67-97-0 6221 10883523 5280795
43
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
44
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
45
Camptothecin Experimental Phase 2 7689-03-4
46 vitamin d Phase 2
47 topoisomerase I inhibitors Phase 2
48 Cyclooxygenase 2 Inhibitors Phase 2
49 Cyclooxygenase Inhibitors Phase 2
50 Nicotinic Acids Phase 2

Interventional clinical trials:

(show top 50) (show all 62)
id Name Status NCT ID Phase
1 Aldara for the Treatment of Large and/or Multiple sBCC Completed NCT00189280 Phase 3
2 Topical Green Tea Ointment in Treatment of Superficial Skin Cancer Completed NCT02029352 Phase 2, Phase 3
3 Metvix PDT in Patients With "High Risk" Basal Cell Carcinoma Completed NCT00473343 Phase 3
4 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
5 Surgery Versus Combined Treatment With Curettage and Imiquimod for Nodular Basal Cell Carcinoma Recruiting NCT02242929 Phase 3
6 A Randomized Controlled Trial of Neoadjuvant Weekly Paclitaxel Versus Weekly Paclitaxel Plus Weekly Carboplatin In Women With Large Operable or Locally Advanced, Triple Negative Breast Cancer Recruiting NCT03168880 Phase 3
7 Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin. Terminated NCT00049959 Phase 3
8 Efficacy, Safety and Tolerability of Topically Applied LDE225 Cream (Hedgehog Pathway Inhibitor) in Adult Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Withdrawn NCT03070691 Phase 2, Phase 3
9 Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas Completed NCT01556009 Phase 2
10 A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin Syndrome Patients Completed NCT00961896 Phase 2
11 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma Completed NCT00108121 Phase 2
12 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Superficial Basal Cell Carcinoma Completed NCT00108134 Phase 2
13 PEP005 Gel - Evaluation of the Safety and Efficacy of Ingenol Mebutate Gel on a Superficial Basal Cell Carcinoma on the Trunk or Extremities Completed NCT01325688 Phase 2
14 To Determine the Maximum Tolerated Dose Level (MTD) of PEP005 Topical Gel in Patients With sBCC Completed NCT00432185 Phase 2
15 Topical Vitamin D3, Diclofenac or a Combination of Both to Treat Basal Cell Carcinoma Completed NCT01358045 Phase 2
16 Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS) Completed NCT01350115 Phase 2
17 Celecoxib in Preventing Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome Completed NCT00023621 Phase 2
18 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Chest and Back Completed NCT00783965 Phase 2
19 Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas (BCC) in Gorlin Syndrome Patients Completed NCT02762084 Phase 2
20 Topical Tazarotene in Treating Patients With Basal Cell Skin Cancer and Basal Cell Nevus Syndrome on the Face Completed NCT00489086 Phase 2
21 To Determine The Efficacy and Safety of GDC-0449 in Patients With Basal Cell Nevus Syndrome (BCNS) Completed NCT00957229 Phase 2
22 Irinotecan/Cisplatin Plus Simvastatin in Extensive Disease-Small Cell Lung Cancer (ED-SCLC) Completed NCT00452634 Phase 2
23 Open-label Trial of SUBA™-Itraconazole (SUBA-Cap) in Subjects With Basal Cell Carcinoma Nevus Syndrome (BCCNS) Recruiting NCT02354261 Phase 2
24 A Study of the Efficacy and Safety of ASN-002 in Adult Patients With Low-risk Nodular Basal Cell Carcinoma Recruiting NCT02550678 Phase 1, Phase 2
25 A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas Active, not recruiting NCT01815840 Phase 2
26 STEVIE: A Study of Vismodegib in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma Active, not recruiting NCT01367665 Phase 2
27 Photodynamic Therapy Using Blue Light or Red Light in Treating Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome Active, not recruiting NCT02258243 Phase 2
28 To Evaluate the Safety, Local Tolerability, PK and PD of LDE225 on Sporadic Superficial and Nodular Skin Basal Cell Carcinomas (sBCC) Terminated NCT01033019 Phase 2
29 Free Soft Tissue Graft in Treatment of Oral Lichen Planus Unknown status NCT00737854 Phase 1
30 A Dose Finding and Safety Study of Oral LEQ506 in Patients With Advanced Solid Tumors Completed NCT01106508 Phase 1
31 A Phase 1 Study of BMS-833923 (XL139) in Subjects With Advanced or Metastatic Cancer Completed NCT00670189 Phase 1
32 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
33 A Study of TAK-441 in Adult Patients With Advanced Nonhematologic Malignancies Completed NCT01204073 Phase 1
34 Safety Study of a Fluorescent Marker to Visualize Cancer Cells Completed NCT02097875 Phase 1
35 Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants Completed NCT00433485 Phase 1
36 GDC-0449 in Treating Patients With Locally Advanced or Metastatic Solid Tumors Completed NCT00607724 Phase 1
37 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1
38 Suberoylanilide Hydroxamic Acid in Treating Patients With Advanced Cancer Completed NCT00045006 Phase 1
39 Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas Recruiting NCT02639117 Phase 1
40 Utility of the Skin Cancer Quality of Life Impact Tool Enrolling by invitation NCT02580916 Phase 1
41 Mohs Versus Traditional Surgery - Basal-Cell Carcinomas (BCC) Unknown status NCT00699829
42 Comparison of Translocator Protein Expression and Binding Activity in Normal Tissue Versus Non Melanotic Malignancy Unknown status NCT01265472
43 Harmonics-based in Vivo Optical Virtual Biopsy Unknown status NCT01980264
44 Prognostic Value of the Marker P63 in Adenocarcinoma of Lung, Breast, and Pancreas Unknown status NCT01942629
45 Intensive Nutrition Counselling in Patients With Head and Neck Cancer Unknown status NCT02159508
46 The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases Completed NCT00005660
47 An Analysis of Treatment Patterns and Outcomes for Basal Cell Carcinoma (BCC) Cancer Patients Completed NCT02100111
48 Multi-Wavelength and Coherence Confocal Reflectance Microscopy of Pigmented and Non-Pigmented Lesions on the Skin In-Vivo Completed NCT00574392
49 Blue vs Red Light During Levulan Based Photodynamic Therapy in Patients With Basal Cell Nevus Syndrome Completed NCT02157623
50 Acitretin in Preventing Skin Cancers in Patients With Previously Treated Skin Cancers Who Have Undergone Organ Transplantation Completed NCT00003611

Search NIH Clinical Center for Basal Cell Carcinoma, Multiple

Genetic Tests for Basal Cell Carcinoma, Multiple

Genetic tests related to Basal Cell Carcinoma, Multiple:

id Genetic test Affiliating Genes
1 Basal Cell Carcinoma, Multiple 29

Anatomical Context for Basal Cell Carcinoma, Multiple

Publications for Basal Cell Carcinoma, Multiple

Variations for Basal Cell Carcinoma, Multiple

Expression for Basal Cell Carcinoma, Multiple

Search GEO for disease gene expression data for Basal Cell Carcinoma, Multiple.

Pathways for Basal Cell Carcinoma, Multiple

Pathways related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.88 CYLD PTCH1

GO Terms for Basal Cell Carcinoma, Multiple

Cellular components related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 midbody GO:0030496 8.62 CYLD PTCH1

Biological processes related to Basal Cell Carcinoma, Multiple according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 8.96 CYP1A1 PTCH1
2 regulation of mitotic cell cycle GO:0007346 8.62 CYLD PTCH1

Sources for Basal Cell Carcinoma, Multiple

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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