MCID: BSL006
MIFTS: 41

Basaloid Squamous Cell Carcinoma malady

Categories: Cancer diseases

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

Aliases & Descriptions for Basaloid Squamous Cell Carcinoma:

Name: Basaloid Squamous Cell Carcinoma 12 14 69
Basaloid Carcinoma 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5522
NCIt 47 C54244
SNOMED-CT 64 128634009
UMLS 69 C1266005

Summaries for Basaloid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary : Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to esophageal basaloid squamous cell carcinoma and cervical basaloid squamous cell carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and skin, and related phenotypes are digestive/alimentary and growth/size/body region

Related Diseases for Basaloid Squamous Cell Carcinoma

Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
id Related Disease Score Top Affiliating Genes
1 esophageal basaloid squamous cell carcinoma 12.3
2 cervical basaloid squamous cell carcinoma 12.1
3 vulvar basaloid squamous cell carcinoma 12.1
4 anus basaloid carcinoma 12.0
5 thymus basaloid carcinoma 11.9
6 penis basaloid carcinoma 11.8
7 basaloid squamous cell skin carcinoma 11.1
8 squamous cell carcinoma 11.0
9 wolffian adnexal neoplasm 10.3 EGFR TP53
10 nervous system hibernoma 10.3 EGFR KRT14
11 conjunctival cancer 10.3 KRT14 TP53
12 clear cell adenofibroma 10.3 CDKN2A TP53
13 lacrimal gland adenoid cystic carcinoma 10.3 CDKN2A TP53
14 laryngitis 10.3
15 cervical benign neoplasm 10.3 SYP TP53
16 pericardium leiomyoma 10.3 CDKN2A TP53
17 clear cell meningioma 10.3 SYP TP53
18 brainstem intraparenchymal clear cell meningioma 10.3 EGFR TP53
19 spondylarthropathy 10.3 CDKN2A TP53
20 vulvar benign neoplasm 10.3 SYP TP53
21 aml with myelodysplasia-related features 10.3 CDKN2A KRT14
22 immunodeficiency due to a classical component pathway complement deficiency 10.3 CDKN2A EGFR
23 blood group incompatibility 10.3 SYP TP53
24 kidney disease 10.2 SYP TP53
25 ebola hemorrhagic fever 10.2 KRT14 KRT17
26 mast-cell sarcoma 10.2 SYP TP53
27 olfactory neuroblastoma 10.2 SYP TP53
28 urethral villous adenoma 10.2 CDKN2A EGFR
29 anal margin basal cell carcinoma 10.2 KRT14 KRT17
30 esophagitis 10.2
31 endometrial squamous cell carcinoma 10.2 CDKN2A TP53
32 small intestine leiomyoma 10.2 KRT17 TP53
33 childhood embryonal testis carcinoma 10.2 EGFR TP53
34 ampulla of vater neoplasm 10.2 CDKN2A TP53
35 bone deterioration disease 10.2 SYP TP53
36 mixed cell adenoma 10.2 KRT14 KRT17
37 coccidiosis 10.2 CDKN2A TP53
38 postpoliomyelitis syndrome 10.2 CDKN2A TP53
39 anal carcinoma in situ 10.2 CDKN2A TP53
40 pineoblastoma 10.2 SYP TP53
41 oro-mandibular-limb hypogenesis syndrome 10.2 CDKN2A TP53
42 brain stem medulloblastoma 10.2 CDKN2A TP53
43 adenoiditis 10.2
44 basal cell carcinoma 10.2
45 uterine disease 10.2 CDKN2A TP53
46 multicentric papillary thyroid carcinoma 10.2 EGFR KRT14 TP53
47 spastic ataxia 5 10.2 CDKN2A TP53
48 camptomelic syndrome long limb type 10.2 KRT8 TP53
49 lymphangitis 10.2 KRT13 TP53
50 adult mesoblastic nephroma 10.2 KRT13 KRT17

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Basaloid Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.87 EGFR KRT14 KRT17 KRT4 KRT8 CDKN2A
2 growth/size/body region MP:0005378 9.86 EGFR KRT14 KRT17 KRT4 KRT8 CDKN2A
3 craniofacial MP:0005382 9.77 TP53 EGFR KRT14 KRT17 KRT4
4 integument MP:0010771 9.63 TP53 EGFR KRT14 KRT17 KRT4 CDKN2A
5 pigmentation MP:0001186 9.43 EGFR KRT14 KRT17 KRT4 CDKN2A TP53
6 reproductive system MP:0005389 9.1 CHGA TP53 EGFR KRT14 KRT8 CDKN2A

Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

Drugs for Basaloid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
2
Fluorouracil Approved Phase 3,Phase 2,Phase 1 51-21-8 3385
3 Antimetabolites Phase 3,Phase 2,Phase 1
4 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1
5 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
6 Alkylating Agents Phase 3,Phase 2
7 Anti-Bacterial Agents Phase 3,Phase 2
8 Antibiotics, Antitubercular Phase 3,Phase 2
9 Mitomycins Phase 3,Phase 2
10 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
11
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 498142 38904
12
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
13
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
14
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
15
Succinylcholine Approved Phase 2 306-40-1 5314
16 Albumin-Bound Paclitaxel Phase 1, Phase 2
17 Antimitotic Agents Phase 1, Phase 2
18 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
19 Neuromuscular Agents Phase 2
20 Neuromuscular Blocking Agents Phase 2
21 Neuromuscular Depolarizing Agents Phase 2
22 Peripheral Nervous System Agents Phase 2
23
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
24 Antibodies Phase 1
25 Antibodies, Monoclonal Phase 1
26 Immunoglobulins Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Unknown status NCT00003652 Phase 3
2 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed NCT00003596 Phase 3
3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer Completed NCT00025090 Phase 3
4 Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous Cancer of the Head and Neck Completed NCT00570674 Phase 1, Phase 2
5 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed NCT00423293 Phase 2
6 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed NCT00324415 Phase 2
7 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer Recruiting NCT02560298 Phase 2
8 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Active, not recruiting NCT00316888 Phase 2
9 Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck Completed NCT00513383 Phase 1

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

Anatomical Context for Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

39
Lung, Cervix, Skin, Trachea, Tonsil, Neutrophil, Bone

Publications for Basaloid Squamous Cell Carcinoma

Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50) (show all 180)
id Title Authors Year
1
Soft Tissue Reconstruction for Basaloid Squamous Cell Carcinoma on the Hemiface. ( 27896203 )
2016
2
Basaloid squamous cell carcinoma arising in an inverted papilloma in the nasal cavity: A case report and review. ( 27720480 )
2016
3
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
4
Basaloid squamous cell carcinoma of oral cavity: Report of two cases. ( 27721627 )
2016
5
Basaloid Squamous Cell Carcinoma of Scalp From A Pre-Existing Cylindroma Metastasising To Brain: A Rare Case Report. ( 27437239 )
2016
6
Basaloid Squamous Cell Carcinoma of the Anus Revisited. ( 26866355 )
2016
7
A Limited Immunohistochemical Panel to Distinguish Basal Cell Carcinoma of Cutaneous Origin From Basaloid Squamous Cell Carcinoma of the Head and Neck. ( 27438511 )
2016
8
Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. ( 25691283 )
2015
9
Basaloid squamous cell carcinoma of the maxilla. ( 26055591 )
2015
10
Basaloid squamous cell carcinoma of the maxilla: Report of a case and literature review. ( 25798549 )
2015
11
Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal. ( 25702956 )
2015
12
Surgical resection and chemoradiotherapy for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the oesophagus. ( 26629851 )
2015
13
Basaloid squamous cell carcinoma of the uterine cervix: Cytological and histological features. ( 26391899 )
2015
14
Basaloid Squamous Cell Carcinoma of the Ethmoid Sinus with Invasion into the Skull Base Treated with Craniofacial Resection and Adjuvant Intensity-Modulated Radiation Therapy: A Case Report. ( 26835192 )
2015
15
Basaloid squamous cell carcinoma of the sinonasal tract with metastasis to the liver: a case report and literature review. ( 25651356 )
2015
16
Basaloid squamous cell carcinoma of cervix showing neuroendocrine differentiation. ( 26148627 )
2015
17
Basaloid Squamous Cell Carcinoma of the Sigmoid Colon. ( 26157950 )
2015
18
Basaloid Squamous Cell Carcinoma: An Unusual Ball-Valve Laryngeal Obstruction. ( 26082908 )
2015
19
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
20
Metastatic primary cutaneous basaloid squamous cell carcinoma: transformation after 20 years of neglect. ( 26336073 )
2015
21
Basaloid Squamous Cell Carcinoma on the Skin of the Hand. ( 26618138 )
2015
22
Surgical management in a rare case of basaloid squamous cell carcinoma of the maxilla. ( 25914753 )
2015
23
Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: a case report. ( 24716457 )
2014
24
PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. ( 25395299 )
2014
25
Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma. ( 23765951 )
2014
26
Reply to letter to the editor regarding investigation of laryngeal basaloid squamous cell carcinoma prognosis. ( 24838783 )
2014
27
Basaloid Squamous Cell Carcinoma of the Conjunctiva. ( 24481508 )
2014
28
Basaloid squamous cell carcinoma of the oropharynx: Comparison of two cases and review of the literature. ( 25283325 )
2014
29
Investigating laryngeal basaloid squamous cell carcinoma prognosis. ( 24838741 )
2014
30
A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts. ( 25400964 )
2014
31
Pathologies en-route of oral basaloid malignancies to basaloid squamous cell carcinoma. ( 25552221 )
2014
32
Basaloid squamous cell carcinoma of the pinna: report of a rare case. ( 24452898 )
2014
33
Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4. ( 24613910 )
2014
34
Basaloid squamous cell carcinoma of the head and neck: location means everything. ( 24464879 )
2014
35
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
36
Basaloid squamous cell carcinoma of the maxillary gingiva: A case report and review of the literature. ( 25120708 )
2014
37
Editorial Comment to Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25376368 )
2014
38
Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25236950 )
2014
39
Surgical Resection of a Solitary Pulmonary Metastasis from Basaloid Squamous Cell Carcinoma of the Esophagus: A Case Report. ( 24088918 )
2013
40
Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression. ( 23833636 )
2013
41
BerEp4, cytokeratin 14, and cytokeratin 17 immunohistochemical staining aid in differentiation of basaloid squamous cell carcinoma from basal cell carcinoma with squamous metaplasia. ( 24168496 )
2013
42
Rapid developing basaloid squamous cell carcinoma of the uterine cervix in a young adult Taiwanese. ( 24362481 )
2013
43
Basaloid squamous cell carcinoma and petrous bone. ( 23598694 )
2013
44
Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course. ( 24051147 )
2013
45
Clinicopathological analysis of basal cell carcinoma of the anal region and its distinction from basaloid squamous cell carcinoma. ( 23599161 )
2013
46
Prognostic significance of basaloid squamous cell carcinoma in head and neck cancer. ( 24158536 )
2013
47
Clinical outcomes of basaloid squamous cell carcinoma of the esophagus: a retrospective analysis of 142 cases. ( 23679289 )
2013
48
Expression of cytokeratin subtypes: MMP-9, p53, and I+SMA to differentiate basaloid squamous cell carcinoma from other basaloid tumors of the oral cavity. ( 23343955 )
2013
49
Transglottic basaloid squamous cell carcinoma of the larynx. ( 24180177 )
2013
50
Basaloid squamous cell carcinoma of the oral cavity: An analysis of 92 cases. ( 23946211 )
2013

Variations for Basaloid Squamous Cell Carcinoma

Expression for Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for Basaloid Squamous Cell Carcinoma

GO Terms for Basaloid Squamous Cell Carcinoma

Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.46 KRT13 KRT14 KRT4 KRT8
2 cell periphery GO:0071944 9.43 KRT14 KRT17 KRT8
3 intermediate filament GO:0005882 9.35 KRT13 KRT14 KRT17 KRT4 KRT8
4 intermediate filament cytoskeleton GO:0045111 8.92 KRT13 KRT17 KRT4 KRT8

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT13 KRT14 KRT17 KRT4 KRT8
2 epidermis development GO:0008544 9.33 EGFR KRT14 KRT17
3 replicative senescence GO:0090399 9.26 CDKN2A TP53
4 cornification GO:0070268 9.02 KRT13 KRT14 KRT17 KRT4 KRT8

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 KRT13 KRT17 KRT4 KRT8

Sources for Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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37 KEGG
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48 NDF-RT
51 NINDS
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54 OMIM
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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