MCID: BSL006
MIFTS: 37

Basaloid Squamous Cell Carcinoma malady

Cancer diseases category

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

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Basaloid Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Basaloid Squamous Cell Carcinoma 9 60
 
Basaloid Carcinoma 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:5522
SNOMED-CT55 128634009
NCIt38 C54244

Summaries for Basaloid Squamous Cell Carcinoma

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Disease Ontology:9 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. it has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary: Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to mucoepidermoid carcinoma and papilloma. An important gene associated with Basaloid Squamous Cell Carcinoma is TP53 (tumor protein p53), and among its related pathways are Colorectal Cancer Metastasis and Direct p53 effectors. The compounds temozolomide and taxane have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and cervix, and related mouse phenotypes are adipose tissue and respiratory system.

Related Diseases for Basaloid Squamous Cell Carcinoma

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Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1mucoepidermoid carcinoma30.5KRT14, EGFR
2papilloma30.5KRT14, TP53
3adenocarcinoma29.9TP53, KRT14, KRT4, EGFR
4esophageal basaloid squamous cell carcinoma10.7
5laryngitis10.7
6adenoiditis10.7
7basal cell carcinoma10.6
8esophagitis10.6
9cervical basaloid squamous cell carcinoma10.6
10vulvar basaloid squamous cell carcinoma10.6
11small cell carcinoma10.6
12anus basaloid carcinoma10.5
13thymus basaloid carcinoma10.5
14giant cell glioblastoma10.4EGFR
15penis basaloid carcinoma10.3
16glomerulonephritis10.3
17basaloid squamous cell skin carcinoma10.3
18ameloblastoma10.3
19penile neoplasm10.3
20eccrine porocarcinoma10.3
21tonsillitis10.3
22trigonitis10.3
23cervicitis10.3
24paraneoplastic syndromes10.3
25breast ductal carcinoma10.2EGFR, TP53
26brain cancer10.2EGFR, TP53
27laryngeal carcinoma10.2EGFR, TP53
28bladder cancer, somatic10.2EGFR, TP53
29laryngeal squamous cell carcinoma10.2TP53, EGFR
30grade iii astrocytoma10.2EGFR, TP53
31renal cell carcinoma10.2EGFR, TP53
32oligodendroglioma10.2EGFR, TP53
33nasopharyngeal carcinoma10.1TP53, EGFR
34neutropenia10.1EGFR, B3GAT1
35squamous cell carcinoma, head and neck10.1EGFR, TP53
36glioblastoma multiforme10.1EGFR, TP53
37keratinizing squamous cell carcinoma10.1
38prostatitis10.1
39pyogenic granuloma10.1
40lung cancer10.1EGFR, TP53
41lung benign neoplasm10.1TP53, EGFR
42cervical cancer, somatic10.0TP53, EGFR
43lung cancer susceptibility 310.0EGFR, TP53
44esophageal cancer10.0KRT14, TP53
45endometrial cancer10.0EGFR, TP53
46astrocytoma10.0EGFR, B3GAT1, TP53
47ovarian cancer, somatic9.9TP53, KRT4, EGFR
48breast cancer9.9EGFR, KRT14
49malignant glioma9.9TP53, EGFR
50ductal carcinoma in situ9.9TP53, KRT14, EGFR

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to basaloid squamous cell carcinoma

Symptoms for Basaloid Squamous Cell Carcinoma

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Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Basaloid Squamous Cell Carcinoma

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

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Anatomical Context for Basaloid Squamous Cell Carcinoma

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MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

31
Lung, Skin, Cervix, Trachea, Bone, Lymph node, Liver, Tonsil

Animal Models for Basaloid Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7EGFR, KRT14, TP53
2MP:00053888.7EGFR, KRT14, TP53
3MP:00020068.6TP53, KRT14, EGFR
4MP:00011868.3EGFR, KRT4, KRT14, TP53
5MP:00053828.2TP53, KRT14, KRT4, EGFR
6MP:00053818.2TP53, KRT14, KRT4, EGFR
7MP:00053918.2EGFR, KRT4, KRT14, TP53
8MP:00107718.1TP53, KRT14, KRT4, EGFR
9MP:00053787.8EGFR, KRT4, KRT14, TP53

Publications for Basaloid Squamous Cell Carcinoma

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Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal. (25702956)
2015
2
Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. (25691283)
2015
3
Basaloid squamous cell carcinoma of the sinonasal tract with metastasis to the liver: a case report and literature review. (25651356)
2015
4
A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts. (25400964)
2014
5
Basaloid squamous cell carcinoma of the oropharynx: Comparison of two cases and review of the literature. (25283325)
2014
6
Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. (25236950)
2014
7
PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. (25395299)
2014
8
Reply to letter to the editor regarding investigation of laryngeal basaloid squamous cell carcinoma prognosis. (24838783)
2014
9
Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression. (23833636)
2013
10
A case of long-term survival after pulmonary resection for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the esophagus. (22721697)
2012
11
Primary intracranial basaloid squamous cell carcinoma: an enigma. (23161194)
2012
12
Basaloid squamous cell carcinoma of the larynx--A systematic review. (21868181)
2012
13
A rare case of basaloid squamous cell carcinoma of the maxilla. (23303037)
2012
14
Basaloid squamous cell carcinoma of the esophagus. (22419439)
2012
15
Basaloid squamous cell carcinoma of the tonsil: report of a case and review of the literature. (23788927)
2012
16
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. (22367299)
2012
17
Basaloid squamous cell carcinoma of nasopharynx: an extremely rare variety of tumour of nasopharynx. (22187772)
2011
18
Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature. (20972844)
2011
19
Basaloid squamous cell carcinoma of the upper aerodigestive tract: a single squamous cell carcinoma subtype or two distinct entities hiding under one histologic pattern? (21125290)
2011
20
Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature. (22529579)
2011
21
Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. (20236687)
2010
22
Basaloid squamous cell carcinoma: report of five cases. (20038913)
2010
23
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. (19738459)
2009
24
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
25
Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. (18291215)
2008
26
Basaloid squamous cell carcinoma of the esophagus: report of two cases. (19155575)
2008
27
Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. (17328988)
2007
28
Basaloid squamous cell carcinoma of the external auditory canal: case report. (17235532)
2007
29
Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. (15899218)
2005
30
Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. (15966703)
2005
31
p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. (15529180)
2005
32
Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. (16758784)
2005
33
Basaloid squamous cell carcinoma of the larynx: a case report. (16444094)
2005
34
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. (15387711)
2004
35
Prognoses of oral basaloid squamous cell carcinoma and squamous cell carcinoma: a comparison. (14732774)
2004
36
Basaloid squamous cell carcinoma of the head and neck. (15167048)
2004
37
Basaloid squamous cell carcinoma report of a case and review of literature. (15164662)
2003
38
Basaloid squamous cell carcinoma of the larynx. (11860655)
2002
39
Basaloid squamous cell carcinoma of the head and neck. (10983946)
2000
40
Basaloid squamous cell carcinoma occurring in the urinary bladder. (10705407)
2000
41
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. (10885705)
2000
42
The basaloid squamous cell carcinoma of the nasopharynx. (11190760)
2000
43
Metastatic laryngeal basaloid squamous cell carcinoma simulating primary small cell carcinoma of the lung on fine needle aspiration lung biopsy. A case report. (9622708)
1998
44
Basaloid squamous cell carcinoma versus basal cell ameloblastoma. (9682780)
1998
45
Basaloid squamous cell carcinoma - larynx. (23119306)
1997
46
Basaloid-squamous cell carcinoma of the floor of the mouth: characterization of a cell line. (9379426)
1997
47
Basaloid squamous cell carcinoma of the upper aerodigestive tract. (11507466)
1997
48
Basaloid-squamous cell carcinoma of the bronchus. Report of a case with review of the literature. (7503668)
1995
49
Basaloid squamous cell carcinoma of floor of mouth. (7691390)
1993
50
Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases. (1384369)
1992

Variations for Basaloid Squamous Cell Carcinoma

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Expression for genes affiliated with Basaloid Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for genes affiliated with Basaloid Squamous Cell Carcinoma

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Pathways related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, EGFR
29.5EGFR, TP53
39.5TP53, EGFR
4
Show member pathways
Signal transduction PTEN pathway58
9.5EGFR, TP53
5
Show member pathways
9.5TP53, EGFR
6
Show member pathways
9.5TP53, EGFR
7
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.5EGFR, TP53
89.5EGFR, TP53
9
Show member pathways
Signaling Pathways in Glioblastoma36
9.5TP53, EGFR
109.5EGFR, TP53
11
Show member pathways
Delta-Notch Signaling Pathway36
Notch Signaling Pathway36
9.5TP53, EGFR
129.5TP53, EGFR
13
Show member pathways
9.5EGFR, TP53
149.5EGFR, TP53
159.5TP53, EGFR
169.5EGFR, TP53
17
Show member pathways
9.5EGFR, TP53
18
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.5EGFR, TP53
19
Show member pathways
9.5TP53, EGFR
209.5EGFR, TP53
219.2TP53, KRT14
229.0KRT4, KRT14

Compounds for genes affiliated with Basaloid Squamous Cell Carcinoma

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Compounds related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1temozolomide43 1210.9TP53, EGFR
2taxane439.8EGFR, TP53
3bcnu439.8TP53, EGFR
4sn 3843 5910.8TP53, EGFR
5topotecan43 1210.8EGFR, TP53
6suberoylanilide hydroxamic acid439.8EGFR, TP53
7oxaliplatin43 49 1211.8EGFR, TP53
8flavopiridol43 1210.8TP53, EGFR
9bortezomib43 49 1211.8EGFR, TP53
10irinotecan43 49 1211.8TP53, EGFR
11carboplatin43 49 1211.7EGFR, TP53
12adpribose439.7EGFR, TP53
13geldanamycin43 49 59 1212.7EGFR, TP53
14gemcitabine43 49 1211.6EGFR, TP53
15thymidylate439.6EGFR, TP53
16docetaxel43 49 59 1212.6EGFR, TP53
17hpvs439.6TP53, KRT14
18egcg439.5TP53, EGFR
19mg 13243 5910.4EGFR, TP53
20curcumin439.2EGFR, TP53
21tamoxifen43 49 28 1212.0EGFR, KRT14, TP53
22vitamin a43 24 1211.0KRT4, KRT14
23paraffin439.0EGFR, KRT14, TP53
24cisplatin43 49 59 1212.0TP53, KRT14, EGFR
25arginine438.9TP53, B3GAT1, KRT14
26retinoid438.4TP53, KRT14, KRT4, EGFR
27retinoic acid43 249.4EGFR, KRT4, KRT14, TP53
28progesterone43 28 59 24 1211.9EGFR, KRT4, KRT14, B3GAT1, TP53
29estrogen437.9TP53, B3GAT1, KRT14, KRT4, EGFR

GO Terms for genes affiliated with Basaloid Squamous Cell Carcinoma

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Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.0KRT4, KRT14
2keratin filamentGO:00450958.7KRT4, KRT14

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:00356909.2EGFR, TP53
2epithelial cell differentiationGO:00308559.0KRT4, KRT14

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:00199039.5EGFR, TP53

Products for genes affiliated with Basaloid Squamous Cell Carcinoma

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  • Antibodies
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Sources for Basaloid Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet