MCID: BSL006
MIFTS: 43

Basaloid Squamous Cell Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

MalaCards integrated aliases for Basaloid Squamous Cell Carcinoma:

Name: Basaloid Squamous Cell Carcinoma 12 14 69
Basaloid Carcinoma 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5522
NCIt 46 C54244
SNOMED-CT 64 128634009

Summaries for Basaloid Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary : Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to esophageal basaloid squamous cell carcinoma and squamous cell carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Carboplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and skin, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Basaloid Squamous Cell Carcinoma

Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 310)
# Related Disease Score Top Affiliating Genes
1 esophageal basaloid squamous cell carcinoma 33.8 EGFR KRT14 TP53
2 squamous cell carcinoma 31.2 CDKN2A EGFR KRT7 TP53
3 squamous cell carcinoma of the larynx 31.0 CDKN2A EGFR TP53
4 squamous cell carcinoma, head and neck 30.8 CDKN2A EGFR TP53
5 squamous cell carcinoma of the oropharynx 30.7 CDKN2A TP53
6 small cell carcinoma 29.6 EGFR ENO2 KRT7 SYP TP53
7 inverted papilloma 29.5 CDKN2A KRT13 KRT7 TP53
8 mucoepidermoid carcinoma 29.4 EGFR KRT13 KRT14 KRT7
9 basal cell carcinoma 28.9 CDKN2A KRT14 KRT17 KRT7 KRT8 TP53
10 papilloma 28.4 CDKN2A KRT13 KRT14 KRT7 KRT8 TP53
11 cervical basaloid squamous cell carcinoma 12.2
12 vulvar basaloid squamous cell carcinoma 12.2
13 thymus basaloid carcinoma 12.2
14 anus basaloid carcinoma 12.1
15 penis basaloid carcinoma 12.0
16 basaloid squamous cell skin carcinoma 11.2
17 malignant spiradenoma 10.5 KRT7 TP53
18 vulvar intraepithelial neoplasia 10.5 KRT7 TP53
19 female reproductive endometrioid cancer 10.5 KRT7 TP53
20 pleomorphic adenoma carcinoma 10.5 ENO2 TP53
21 cellular ependymoma 10.4 SYP TP53
22 breast benign neoplasm 10.4 KRT14 TP53
23 malignant sertoli cell tumor 10.4 ENO2 SYP
24 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
25 papillary serous adenocarcinoma 10.4 KRT7 TP53
26 thoracic benign neoplasm 10.4 KRT14 TP53
27 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
28 auditory system cancer 10.4 ENO2 SYP
29 cutaneous ganglioneuroma 10.4 ENO2 SYP
30 gallbladder small cell carcinoma 10.4 ENO2 SYP
31 brain stem astrocytic neoplasm 10.4 CDKN2A TP53
32 pancreatic somatostatinoma 10.4 ENO2 SYP
33 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
34 papillary tumor of the pineal region 10.4 ENO2 SYP
35 orbital cancer 10.4 ENO2 SYP
36 ovarian carcinosarcoma 10.4 ENO2 SYP
37 pulmonary large cell neuroendocrine carcinoma 10.4 ENO2 SYP
38 subependymal glioma 10.4 ENO2 SYP
39 ovarian large-cell neuroendocrine carcinoma 10.4 KRT7 SYP
40 olfactory nerve neoplasm 10.4 ENO2 SYP
41 ameloblastic carcinoma 10.4 CDKN2A KRT14
42 spitz nevus 10.4 CDKN2A TP53
43 cauda equina neoplasm 10.4 ENO2 SYP
44 mucinous adenofibroma 10.4 KRT7 SYP
45 extraosseous chondrosarcoma 10.4 ENO2 SYP
46 benign ependymoma 10.4 ENO2 SYP
47 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
48 malignant teratoma 10.4 ENO2 SYP
49 astroblastoma 10.4 ENO2 SYP
50 bartholin's gland benign neoplasm 10.4 CDKN2A TP53

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to Basaloid Squamous Cell Carcinoma

Symptoms & Phenotypes for Basaloid Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 EGFR ENO2 KRT14 KRT17 TP53
2 digestive/alimentary MP:0005381 9.43 CDKN2A EGFR KRT14 KRT17 KRT8 TP53
3 pigmentation MP:0001186 9.02 CDKN2A EGFR KRT14 KRT17 TP53

Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

Drugs for Basaloid Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
2
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
3
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
4 Albumin-Bound Paclitaxel Phase 1, Phase 2
5 Antimitotic Agents Phase 1, Phase 2
6 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
7
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
8
Fluorouracil Approved Phase 1 51-21-8 3385
9
Docetaxel Approved May 1996, Investigational Phase 1 114977-28-5 148124 9877265
10 Antibodies Phase 1
11 Antibodies, Monoclonal Phase 1
12 Antimetabolites Phase 1
13 Antimetabolites, Antineoplastic Phase 1
14 Immunoglobulins Phase 1
15 Immunosuppressive Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Abraxane in Combination With Carboplatin, Erbitux and IMRT for Locally Advanced Squamous Cancer of the Head and Neck Terminated NCT00570674 Phase 1, Phase 2 Abraxane;Erbitux;Carboplatin
2 Panitumumab Chemoradiotherapy Chemotherapy for Squamous Cancer of the Head and Neck Completed NCT00513383 Phase 1 Panitumumab;Carboplatin;Paclitaxel;5-Fluorouracil;Docetaxel;Cisplatin

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

Anatomical Context for Basaloid Squamous Cell Carcinoma

MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

38
Lung, Cervix, Skin, Trachea, Tonsil, Tongue, Neutrophil

Publications for Basaloid Squamous Cell Carcinoma

Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50) (show all 191)
# Title Authors Year
1
A Case of Basaloid Squamous Cell Carcinoma of Polypoid Type in the Esophagus. ( 29033778 )
2017
2
A novel gene expression scoring system for accurate diagnosis of basaloid squamous cell carcinoma of the esophagus. ( 28731134 )
2017
3
Basaloid Squamous Cell Carcinoma of the Lung Associated With Syndrome of Inappropriate Antidiuretic Hormone Secretion. ( 29317964 )
2017
4
Clinicopahological features of superficial basaloid squamous cell carcinoma of the esophagus. ( 28881881 )
2017
5
Bilateral Basaloid Squamous Cell Carcinoma of the Parotid Gland: A Case Report and Review of the Literature. ( 28333602 )
2017
6
Subcutaneous metastasis from recurrent basaloid squamous cell carcinoma of the esophagus. ( 29078709 )
2017
7
Basaloid Squamous Cell Carcinoma of Tongue: A Report with Emphasis on Immunohistochemistry. ( 28511524 )
2017
8
Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx. ( 29221167 )
2017
9
Cytomorphology of Basaloid Squamous Cell Carcinoma: A Diagnostic Dilemma. ( 28571158 )
2017
10
Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus. ( 28593937 )
2017
11
A long-surviving patient with advanced esophageal basaloid squamous cell carcinoma treated only with radiotherapy: case report and literature review. ( 29216832 )
2017
12
Basaloid Squamous Cell Carcinoma of the Anus Revisited. ( 26866355 )
2016
13
The Preoperative Neutrophil-To-Lymphocyte Ratio Is a Novel Immune Parameter for the Prognosis of Esophageal Basaloid Squamous Cell Carcinoma. ( 27959959 )
2016
14
Basaloid Squamous Cell Carcinoma of Scalp From A Pre-Existing Cylindroma Metastasising To Brain: A Rare Case Report. ( 27437239 )
2016
15
Soft Tissue Reconstruction for Basaloid Squamous Cell Carcinoma on the Hemiface. ( 27896203 )
2016
16
A Limited Immunohistochemical Panel to Distinguish Basal Cell Carcinoma of Cutaneous Origin From Basaloid Squamous Cell Carcinoma of the Head and Neck. ( 27438511 )
2016
17
Basaloid squamous cell carcinoma arising in an inverted papilloma in the nasal cavity: A case report and review. ( 27720480 )
2016
18
Basaloid squamous cell carcinoma of oral cavity: Report of two cases. ( 27721627 )
2016
19
Basaloid Squamous Cell Carcinoma: An Unusual Ball-Valve Laryngeal Obstruction. ( 26082908 )
2015
20
Molecular pathology and potential therapeutic targets in esophageal basaloid squamous cell carcinoma. ( 26045734 )
2015
21
Basal cell carcinoma vs basaloid squamous cell carcinoma of the skin: an immunohistochemical reappraisal. ( 25702956 )
2015
22
Basaloid squamous cell carcinoma of the uterine cervix: Cytological and histological features. ( 26391899 )
2015
23
Molecular Characteristics of Basaloid Squamous Cell Carcinoma of the Esophagus: Analysis of KRAS, BRAF, and PIK3CA Mutations and LINE-1 Methylation. ( 25691283 )
2015
24
Basaloid Squamous Cell Carcinoma of the Ethmoid Sinus with Invasion into the Skull Base Treated with Craniofacial Resection and Adjuvant Intensity-Modulated Radiation Therapy: A Case Report. ( 26835192 )
2015
25
Basaloid Squamous Cell Carcinoma of the Sigmoid Colon. ( 26157950 )
2015
26
Basaloid Squamous Cell Carcinoma on the Skin of the Hand. ( 26618138 )
2015
27
Basaloid squamous cell carcinoma of the maxilla. ( 26055591 )
2015
28
Surgical resection and chemoradiotherapy for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the oesophagus. ( 26629851 )
2015
29
Surgical management in a rare case of basaloid squamous cell carcinoma of the maxilla. ( 25914753 )
2015
30
Metastatic primary cutaneous basaloid squamous cell carcinoma: transformation after 20 years of neglect. ( 26336073 )
2015
31
Basaloid squamous cell carcinoma of cervix showing neuroendocrine differentiation. ( 26148627 )
2015
32
Basaloid squamous cell carcinoma of the maxilla: Report of a case and literature review. ( 25798549 )
2015
33
Basaloid squamous cell carcinoma of the sinonasal tract with metastasis to the liver: a case report and literature review. ( 25651356 )
2015
34
Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma. ( 23765951 )
2014
35
Reply to letter to the editor regarding investigation of laryngeal basaloid squamous cell carcinoma prognosis. ( 24838783 )
2014
36
Editorial Comment to Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25376368 )
2014
37
Basaloid squamous cell carcinoma of the maxillary gingiva: A case report and review of the literature. ( 25120708 )
2014
38
Basaloid squamous cell carcinoma in the nasal cavity treated with proton beam therapy concurrent with cisplatin: a case report. ( 24716457 )
2014
39
PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. ( 25395299 )
2014
40
Basaloid Squamous Cell Carcinoma of the Conjunctiva. ( 24481508 )
2014
41
A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts. ( 25400964 )
2014
42
Basaloid squamous cell carcinoma of the head and neck: location means everything. ( 24464879 )
2014
43
Basaloid squamous cell carcinoma of the pinna: report of a rare case. ( 24452898 )
2014
44
Basaloid squamous cell carcinoma of the oropharynx: Comparison of two cases and review of the literature. ( 25283325 )
2014
45
Basaloid squamous cell carcinoma: a rare tumor at the esophagogastric junction and an unexpected durable complete response to FOLFOX-4. ( 24613910 )
2014
46
Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. ( 25236950 )
2014
47
Investigating laryngeal basaloid squamous cell carcinoma prognosis. ( 24838741 )
2014
48
Pathologies en-route of oral basaloid malignancies to basaloid squamous cell carcinoma. ( 25552221 )
2014
49
Downregulation of sFRP-2 by epigenetic silencing activates the I^-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. ( 24464051 )
2014
50
Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course. ( 24051147 )
2013

Variations for Basaloid Squamous Cell Carcinoma

Expression for Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for Basaloid Squamous Cell Carcinoma

GO Terms for Basaloid Squamous Cell Carcinoma

Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 9.43 KRT14 KRT17 KRT8
2 intermediate filament cytoskeleton GO:0045111 9.33 KRT13 KRT17 KRT8
3 keratin filament GO:0045095 9.26 KRT13 KRT14 KRT7 KRT8
4 intermediate filament GO:0005882 9.02 KRT13 KRT14 KRT17 KRT7 KRT8

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.35 KRT13 KRT14 KRT17 KRT7 KRT8
2 epidermis development GO:0008544 9.33 EGFR KRT14 KRT17
3 replicative senescence GO:0090399 9.26 CDKN2A TP53
4 cornification GO:0070268 9.02 KRT13 KRT14 KRT17 KRT7 KRT8

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.92 KRT13 KRT17 KRT7 KRT8

Sources for Basaloid Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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