MCID: BSL006
MIFTS: 45

Basaloid Squamous Cell Carcinoma malady

Cancer diseases category
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Summaries for Basaloid Squamous Cell Carcinoma

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Disease Ontology:8 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. it has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards based summary: Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to squamous cell carcinoma of the head and neck and mucoepidermoid carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is TP53 (tumor protein p53), and among its related pathways are Colorectal Cancer Metastasis and Direct p53 effectors. The compounds temozolomide and taxane have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and skin, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

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Basaloid Squamous Cell Carcinoma, Aliases & Descriptions:

Name: Basaloid Squamous Cell Carcinoma 8 62
 
Basaloid Carcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5522
SNOMED-CT57 128634009
NCIt39 C54244

Related Diseases for Basaloid Squamous Cell Carcinoma

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Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma of the head and neck31.5TP53, EGFR
2mucoepidermoid carcinoma30.5KRT14, EGFR
3papilloma30.5TP53, KRT14
4adenocarcinoma29.9KRT4, EGFR, TP53, KRT14
5esophageal basaloid squamous cell carcinoma10.7
6laryngitis10.7
7adenoiditis10.7
8esophagitis10.6
9cervical basaloid squamous cell carcinoma10.6
10vulvar basaloid squamous cell carcinoma10.6
11small cell carcinoma10.6
12basal cell carcinoma10.6
13basaloid squamous cell skin carcinoma10.5
14tonsillitis10.5
15thymus basaloid carcinoma10.4
16giant cell glioblastoma10.4EGFR
17anus basaloid carcinoma10.4
18glomerulonephritis10.3
19eccrine porocarcinoma10.3
20trigonitis10.3
21ameloblastoma10.3
22penile neoplasm10.3
23cervicitis10.3
24osteosarcoma10.3
25paraneoplastic syndromes10.3
26penis basaloid carcinoma10.2
27breast ductal carcinoma10.2EGFR, TP53
28brain cancer10.2TP53, EGFR
29laryngeal benign neoplasm10.2EGFR, TP53
30bladder carcinoma in situ10.2EGFR, TP53
31laryngeal squamous cell carcinoma10.2TP53, EGFR
32grade iii astrocytoma10.2EGFR, TP53
33kidney cancer10.2TP53, EGFR
34oligodendroglioma10.2TP53, EGFR
35nasopharynx carcinoma10.2TP53, EGFR
36neutropenia10.1B3GAT1, EGFR
37glioblastoma multiforme10.1TP53, EGFR
38non-small cell lung carcinoma10.1TP53, EGFR
39keratinizing squamous cell carcinoma10.1
40pyogenic granuloma10.1
41lung benign neoplasm10.1EGFR, TP53
42breast cancer, invasive ductal10.1KRT14, TP53
43cervical cancer10.0TP53, EGFR
44lung adenocarcinoma10.0TP53, EGFR
45esophageal cancer10.0KRT14, TP53
46endometrial carcinoma10.0TP53, EGFR
47astrocytoma10.0B3GAT1, EGFR, TP53
48ovarian cancer9.9KRT4, EGFR, TP53
49malignant glioma9.9EGFR, TP53
50breast cancer9.9EGFR, KRT14

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to basaloid squamous cell carcinoma

Symptoms for Basaloid Squamous Cell Carcinoma

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Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Basaloid Squamous Cell Carcinoma

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

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Anatomical Context for Basaloid Squamous Cell Carcinoma

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MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

32
Lung, Cervix, Skin, Tonsil, Trachea, Bone, Lymph node

Animal Models for Basaloid Squamous Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7KRT14, EGFR, TP53
2MP:00053888.7TP53, KRT14, EGFR
3MP:00020068.6KRT14, EGFR, TP53
4MP:00011868.3TP53, KRT14, KRT4, EGFR
5MP:00053828.2TP53, KRT14, KRT4, EGFR
6MP:00053818.2KRT4, KRT14, TP53, EGFR
7MP:00053918.2EGFR, KRT4, KRT14, TP53
8MP:00107718.1EGFR, TP53, KRT14, KRT4
9MP:00053787.8TP53, EGFR, KRT4, KRT14

Publications for Basaloid Squamous Cell Carcinoma

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Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
A fatal case of primary basaloid squamous cell carcinoma in the intrahepatic bile ducts. (25400964)
2014
2
Basaloid squamous cell carcinoma of the oropharynx: Comparison of two cases and review of the literature. (25283325)
2014
3
Human papillomavirus-related basaloid squamous cell carcinoma of the bladder associated with genital tract human papillomavirus infection. (25236950)
2014
4
PTCH1 mutation is a frequent event in oesophageal basaloid squamous cell carcinoma. (25395299)
2014
5
Reply to letter to the editor regarding investigation of laryngeal basaloid squamous cell carcinoma prognosis. (24838783)
2014
6
Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression. (23833636)
2013
7
Basaloid squamous cell carcinoma of the tonsil. (23930063)
2012
8
A case of long-term survival after pulmonary resection for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the esophagus. (22721697)
2012
9
Primary intracranial basaloid squamous cell carcinoma: an enigma. (23161194)
2012
10
Basaloid squamous cell carcinoma of the larynx--A systematic review. (21868181)
2012
11
A rare case of basaloid squamous cell carcinoma of the maxilla. (23303037)
2012
12
Basaloid squamous cell carcinoma of the esophagus. (22419439)
2012
13
Basaloid squamous cell carcinoma of the tonsil: report of a case and review of the literature. (23788927)
2012
14
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. (22367299)
2012
15
Basaloid squamous cell carcinoma of nasopharynx: an extremely rare variety of tumour of nasopharynx. (22187772)
2011
16
Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature. (20972844)
2011
17
Basaloid squamous cell carcinoma of the upper aerodigestive tract: a single squamous cell carcinoma subtype or two distinct entities hiding under one histologic pattern? (21125290)
2011
18
Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature. (22529579)
2011
19
Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. (20236687)
2010
20
Basaloid squamous cell carcinoma: report of five cases. (20038913)
2010
21
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. (19738459)
2009
22
Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. (19248560)
2009
23
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
24
Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. (18291215)
2008
25
Basaloid squamous cell carcinoma of the esophagus: report of two cases. (19155575)
2008
26
Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. (17328988)
2007
27
Basaloid squamous cell carcinoma of the external auditory canal: case report. (17235532)
2007
28
Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. (15899218)
2005
29
Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. (15966703)
2005
30
p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. (15529180)
2005
31
Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. (16758784)
2005
32
Basaloid squamous cell carcinoma of the larynx: a case report. (16444094)
2005
33
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. (15387711)
2004
34
Prognoses of oral basaloid squamous cell carcinoma and squamous cell carcinoma: a comparison. (14732774)
2004
35
Basaloid squamous cell carcinoma of the head and neck. (15167048)
2004
36
Basaloid squamous cell carcinoma report of a case and review of literature. (15164662)
2003
37
Basaloid squamous cell carcinoma of the larynx. (11860655)
2002
38
Basaloid squamous cell carcinoma of the head and neck. (10983946)
2000
39
Basaloid squamous cell carcinoma occurring in the urinary bladder. (10705407)
2000
40
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. (10885705)
2000
41
The basaloid squamous cell carcinoma of the nasopharynx. (11190760)
2000
42
Metastatic laryngeal basaloid squamous cell carcinoma simulating primary small cell carcinoma of the lung on fine needle aspiration lung biopsy. A case report. (9622708)
1998
43
Basaloid squamous cell carcinoma versus basal cell ameloblastoma. (9682780)
1998
44
Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. (9635682)
1998
45
Basaloid squamous cell carcinoma - larynx. (23119306)
1997
46
Basaloid-squamous cell carcinoma of the floor of the mouth: characterization of a cell line. (9379426)
1997
47
Basaloid squamous cell carcinoma of the upper aerodigestive tract. (11507466)
1997
48
Basaloid-squamous cell carcinoma of the bronchus. Report of a case with review of the literature. (7503668)
1995
49
Basaloid squamous cell carcinoma of floor of mouth. (7691390)
1993
50
Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases. (1384369)
1992

Variations for Basaloid Squamous Cell Carcinoma

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Expression for genes affiliated with Basaloid Squamous Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for genes affiliated with Basaloid Squamous Cell Carcinoma

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Pathways related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, EGFR
29.5EGFR, TP53
39.5TP53, EGFR
4
Show member pathways
Signal transduction PTEN pathway60
9.5EGFR, TP53
5
Show member pathways
9.5TP53, EGFR
6
Show member pathways
9.5TP53, EGFR
7
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.5EGFR, TP53
89.5EGFR, TP53
9
Show member pathways
Signaling Pathways in Glioblastoma37
9.5TP53, EGFR
109.5EGFR, TP53
11
Show member pathways
Delta-Notch Signaling Pathway37
Notch Signaling Pathway37
9.5TP53, EGFR
129.5TP53, EGFR
13
Show member pathways
9.5EGFR, TP53
149.5EGFR, TP53
159.5TP53, EGFR
169.5EGFR, TP53
17
Show member pathways
9.5EGFR, TP53
18
Show member pathways
ErbB receptor signaling network37
ErbB signaling pathway37
9.5EGFR, TP53
19
Show member pathways
9.5TP53, EGFR
209.5EGFR, TP53
219.2TP53, KRT14
229.0KRT4, KRT14

Compounds for genes affiliated with Basaloid Squamous Cell Carcinoma

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Compounds related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1temozolomide44 1110.9EGFR, TP53
2taxane449.8EGFR, TP53
3bcnu449.8EGFR, TP53
4sn 3844 6110.8EGFR, TP53
5topotecan44 1110.8TP53, EGFR
6suberoylanilide hydroxamic acid449.8TP53, EGFR
7oxaliplatin44 50 1111.8EGFR, TP53
8flavopiridol44 1110.8TP53, EGFR
9bortezomib44 50 1111.8TP53, EGFR
10irinotecan44 50 1111.8TP53, EGFR
11carboplatin44 50 1111.7TP53, EGFR
12adpribose449.7TP53, EGFR
13geldanamycin44 50 61 1112.7TP53, EGFR
14gemcitabine44 50 1111.6TP53, EGFR
15thymidylate449.6EGFR, TP53
16docetaxel44 50 61 1112.6TP53, EGFR
17hpvs449.6TP53, KRT14
18egcg449.5TP53, EGFR
19mg 13244 6110.4TP53, EGFR
20curcumin449.2EGFR, TP53
21tamoxifen44 50 28 1112.0KRT14, TP53, EGFR
22vitamin a44 24 1111.0KRT4, KRT14
23paraffin449.0EGFR, TP53, KRT14
24cisplatin44 50 61 1112.0EGFR, TP53, KRT14
25arginine448.9KRT14, B3GAT1, TP53
26retinoid448.4KRT4, TP53, EGFR, KRT14
27retinoic acid44 249.4TP53, KRT14, KRT4, EGFR
28progesterone44 28 61 24 1111.9EGFR, KRT4, KRT14, B3GAT1, TP53
29estrogen447.9EGFR, KRT4, TP53, B3GAT1, KRT14

GO Terms for genes affiliated with Basaloid Squamous Cell Carcinoma

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Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0KRT4, KRT14
2keratin filamentGO:0450958.7KRT4, KRT14

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.2EGFR, TP53
2epithelial cell differentiationGO:0308559.0KRT4, KRT14

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.5EGFR, TP53

Products for genes affiliated with Basaloid Squamous Cell Carcinoma

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Sources for Basaloid Squamous Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet