MCID: BSL006
MIFTS: 44

Basaloid Squamous Cell Carcinoma malady

Cancer diseases category

Summaries for Basaloid Squamous Cell Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. it has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma.

MalaCards: Basaloid Squamous Cell Carcinoma, also known as basaloid carcinoma, is related to squamous cell carcinoma of the head and neck and mucoepidermoid carcinoma. An important gene associated with Basaloid Squamous Cell Carcinoma is TP53 (tumor protein p53), and among its related pathways are Colorectal Cancer Metastasis and Direct p53 effectors. The compounds temozolomide and taxane have been mentioned in the context of this disorder. Affiliated tissues include lung, cervix and skin, and related mouse phenotypes are adipose tissue and respiratory system.

Aliases & Classifications for Basaloid Squamous Cell Carcinoma

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

basaloid squamous cell carcinoma 9 63
basaloid carcinoma 9 63


External Ids:

Disease Ontology9 DOID:5522
SNOMED-CT59 128634009
NCIt41 C54244

Related Diseases for Basaloid Squamous Cell Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Basaloid Squamous Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma of the head and neck31.3EGFR, TP53, KRT14
2mucoepidermoid carcinoma30.5KRT14, EGFR
3papilloma30.5TP53, KRT14
4adenocarcinoma30.3KRT4, EGFR, TP53, KRT14
5adenoiditis10.7
6esophageal basaloid squamous cell carcinoma10.6
7laryngitis10.6
8small cell carcinoma10.5
9basal cell carcinoma10.5
10esophagitis10.5
11cervical basaloid squamous cell carcinoma10.5
12vulvar basaloid squamous cell carcinoma10.5
13tonsillitis10.5
14adenoid cystic carcinoma10.5
15anus basaloid carcinoma10.4
16thymus basaloid carcinoma10.4
17basaloid squamous cell skin carcinoma10.3
18penile neoplasm10.3
19eccrine porocarcinoma10.3
20trigonitis10.3
21cervicitis10.3
22glomerulonephritis10.3
23osteosarcoma10.3
24paraneoplastic syndromes10.3
25penis basaloid carcinoma10.2
26giant cell glioblastoma10.1EGFR
27keratinizing squamous cell carcinoma10.1
28prostatitis10.1
29pyogenic granuloma10.1
30brain cancer10.0TP53, EGFR
31laryngeal benign neoplasm10.0EGFR, TP53
32bladder carcinoma in situ10.0EGFR, TP53
33laryngeal squamous cell carcinoma10.0TP53, EGFR
34anaplastic astrocytoma10.0EGFR, TP53
35kidney cancer10.0TP53, EGFR
36oligodendroglioma10.0TP53, EGFR
37nasopharynx carcinoma10.0TP53, EGFR
38neutropenia10.0B3GAT1, EGFR
39glioblastoma multiforme10.0TP53, EGFR
40non-small cell lung carcinoma10.0TP53, EGFR
41lung benign neoplasm10.0EGFR, TP53
42breast cancer, invasive ductal10.0KRT14, TP53
43cervical cancer10.0TP53, EGFR
44lung adenocarcinoma10.0TP53, EGFR
45esophageal cancer10.0KRT14, TP53
46endometrial carcinoma10.0TP53, EGFR
47astrocytoma10.0B3GAT1, EGFR, TP53
48ovarian cancer10.0KRT4, EGFR, TP53
49breast cancer10.0EGFR, KRT14
50malignant glioma10.0EGFR, TP53

Graphical network of the top 20 diseases related to Basaloid Squamous Cell Carcinoma:



Diseases related to basaloid squamous cell carcinoma

Symptoms for Basaloid Squamous Cell Carcinoma

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Drugs & Therapeutics for Basaloid Squamous Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Basaloid Squamous Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Basaloid Squamous Cell Carcinoma

Search NIH Clinical Center for Basaloid Squamous Cell Carcinoma

Search CenterWatch for Basaloid Squamous Cell Carcinoma

Genetic Tests for Basaloid Squamous Cell Carcinoma

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Anatomical Context for Basaloid Squamous Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Basaloid Squamous Cell Carcinoma:

34
Lung, Cervix, Skin, Trachea, Tonsil, Bone, Lymph node

Animal Models for Basaloid Squamous Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Basaloid Squamous Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7EGFR, KRT14, TP53
2MP:00053888.7EGFR, KRT14, TP53
3MP:00020068.6TP53, KRT14, EGFR
4MP:00011868.3EGFR, KRT4, KRT14, TP53
5MP:00053828.2TP53, KRT14, KRT4, EGFR
6MP:00053818.2TP53, KRT14, KRT4, EGFR
7MP:00053918.2EGFR, KRT4, KRT14, TP53
8MP:00107718.1TP53, KRT14, KRT4, EGFR
9MP:00053787.8EGFR, KRT4, KRT14, TP53

Publications for Basaloid Squamous Cell Carcinoma

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53PubMed
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Articles related to Basaloid Squamous Cell Carcinoma:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Basaloid squamous cell carcinoma of the maxillary sinus: Report of two cases in association with cathepsin K expression. (23833636)
2013
2
Basaloid squamous cell carcinoma of the oropharynx: an analysis of 650 cases. (23386625)
2013
3
Basaloid squamous cell carcinoma of the tonsil. (23930063)
2012
4
A case of long-term survival after pulmonary resection for metachronous pulmonary metastasis of basaloid squamous cell carcinoma of the esophagus. (22721697)
2012
5
Primary intracranial basaloid squamous cell carcinoma: an enigma. (23161194)
2012
6
Basaloid squamous cell carcinoma of the larynx--A systematic review. (21868181)
2012
7
A rare case of basaloid squamous cell carcinoma of the maxilla. (23303037)
2012
8
Basaloid squamous cell carcinoma of the esophagus. (22419439)
2012
9
Basaloid squamous cell carcinoma of the tonsil: report of a case and review of the literature. (23788927)
2012
10
Basaloid squamous cell carcinoma of the penis with papillary features: a clinicopathologic study of 12 cases. (22367299)
2012
11
Basaloid squamous cell carcinoma of nasopharynx: an extremely rare variety of tumour of nasopharynx. (22187772)
2011
12
Sphenoid sinus basaloid squamous cell carcinoma presenting as a sellar mass: report a case with review of the literature. (20972844)
2011
13
Basaloid squamous cell carcinoma of the upper aerodigestive tract: a single squamous cell carcinoma subtype or two distinct entities hiding under one histologic pattern? (21125290)
2011
14
Basaloid squamous cell carcinoma of retromolar trigone: A case report with review of literature. (22529579)
2011
15
Human papillomavirus-positive basaloid squamous cell carcinomas of the upper aerodigestive tract: a distinct clinicopathologic and molecular subtype of basaloid squamous cell carcinoma. (20236687)
2010
16
Basaloid squamous cell carcinoma: report of five cases. (20038913)
2010
17
Basaloid squamous cell carcinoma of the esophagus: assessment for high-risk human papillomavirus and related molecular markers. (19738459)
2009
18
Cytomorphologic diagnosis of basaloid squamous cell carcinoma: a case report. (19248560)
2009
19
Histological diversity in basaloid squamous cell carcinoma of the esophagus. (18847449)
2009
20
Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. (18496144)
2008
21
Esophageal carcinosarcoma with basaloid squamous cell carcinoma and osteosarcoma. (18291215)
2008
22
Basaloid squamous cell carcinoma of the esophagus: report of two cases. (19155575)
2008
23
A clinicopathologic study on basaloid squamous cell carcinoma in the oral and maxillofacial region. (18632253)
2008
24
Basaloid squamous cell carcinoma of the lung: a rare tumour with a rare clinical presentation. (17328988)
2007
25
Basaloid squamous cell carcinoma of the external auditory canal: case report. (17235532)
2007
26
High nuclear expression of the apoptosis inhibitor protein survivin is associated with disease recurrence and poor prognosis in laryngeal basaloid squamous cell carcinoma. (16428200)
2006
27
Immunoexpression of p53, Ki-67 and E-cadherin in basaloid squamous cell carcinoma of the larynx. (15899218)
2005
28
Endoglin (CD105) expression in head and neck basaloid squamous cell carcinoma. (15966703)
2005
29
p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. (15529180)
2005
30
Case reports of basaloid squamous cell carcinoma--an aggressive variant of squamous cell carcinoma. (16758784)
2005
31
Basaloid squamous cell carcinoma of the larynx: a case report. (16444094)
2005
32
Basaloid squamous cell carcinoma of the esophagus with or without adenoid cystic features. (15387711)
2004
33
Prognoses of oral basaloid squamous cell carcinoma and squamous cell carcinoma: a comparison. (14732774)
2004
34
Basaloid squamous cell carcinoma of the head and neck. (15167048)
2004
35
Basaloid squamous cell carcinoma report of a case and review of literature. (15164662)
2003
36
Basaloid squamous cell carcinoma of the larynx. (11860655)
2002
37
Basaloid-squamous cell carcinoma of the esophagus: diagnosis based on immunohistochemical analysis. (11350561)
2001
38
Basaloid squamous cell carcinoma of the head and neck. (10983946)
2000
39
Basaloid squamous cell carcinoma occurring in the urinary bladder. (10705407)
2000
40
An isolated digital metastasis of esophageal basaloid squamous cell carcinoma. (10885705)
2000
41
The basaloid squamous cell carcinoma of the nasopharynx. (11190760)
2000
42
Metastatic laryngeal basaloid squamous cell carcinoma simulating primary small cell carcinoma of the lung on fine needle aspiration lung biopsy. A case report. (9622708)
1998
43
Basaloid squamous cell carcinoma versus basal cell ameloblastoma. (9682780)
1998
44
Distinction of basaloid squamous cell carcinoma from adenoid cystic and small cell undifferentiated carcinoma by immunohistochemistry. (9635682)
1998
45
Basaloid squamous cell carcinoma - larynx. (23119306)
1997
46
Basaloid-squamous cell carcinoma of the floor of the mouth: characterization of a cell line. (9379426)
1997
47
Basaloid squamous cell carcinoma of the upper aerodigestive tract. (11507466)
1997
48
Basaloid-squamous cell carcinoma of the bronchus. Report of a case with review of the literature. (7503668)
1995
49
Basaloid squamous cell carcinoma of floor of mouth. (7691390)
1993
50
Basaloid squamous cell carcinoma of the head and neck. A clinicopathologic and immunohistochemical study of 40 cases. (1384369)
1992

Variations for Basaloid Squamous Cell Carcinoma

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Expression for genes affiliated with Basaloid Squamous Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Basaloid Squamous Cell Carcinoma

Search GEO for disease gene expression data for Basaloid Squamous Cell Carcinoma.

Pathways for genes affiliated with Basaloid Squamous Cell Carcinoma

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 62Tocris Bioscience, 56Reactome, 55R&D Systems, 58SinoBiological, 52PharmGKB
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Pathways related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TP53, EGFR
29.5EGFR, TP53
39.5TP53, EGFR
4
Show member pathways
Signal transduction PTEN pathway61
9.5EGFR, TP53
5
Show member pathways
9.5TP53, EGFR
6
Show member pathways
9.5TP53, EGFR
7
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.5EGFR, TP53
89.5EGFR, TP53
9
Show member pathways
Signaling Pathways in Glioblastoma39
9.5TP53, EGFR
109.5EGFR, TP53
11
Show member pathways
Delta-Notch Signaling Pathway39
Notch Signaling Pathway39
9.5TP53, EGFR
129.5TP53, EGFR
13
Show member pathways
9.5EGFR, TP53
149.5EGFR, TP53
159.5TP53, EGFR
169.5EGFR, TP53
17
Show member pathways
9.5EGFR, TP53
18
Show member pathways
ErbB receptor signaling network39
ErbB signaling pathway39
9.5EGFR, TP53
19
Show member pathways
9.5TP53, EGFR
209.5EGFR, TP53
219.2TP53, KRT14
229.0KRT4, KRT14

Compounds for genes affiliated with Basaloid Squamous Cell Carcinoma

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB
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Compounds related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1temozolomide46 1210.9TP53, EGFR
2taxane469.8EGFR, TP53
3bcnu469.8TP53, EGFR
4sn 3846 6210.8TP53, EGFR
5topotecan46 1210.8EGFR, TP53
6suberoylanilide hydroxamic acid469.8EGFR, TP53
7oxaliplatin46 52 1211.8EGFR, TP53
8flavopiridol46 1210.8TP53, EGFR
9bortezomib46 52 1211.8EGFR, TP53
10irinotecan46 52 1211.8TP53, EGFR
11carboplatin46 52 1211.7EGFR, TP53
12adpribose469.7EGFR, TP53
13geldanamycin46 52 62 1212.7EGFR, TP53
14gemcitabine46 52 1211.6EGFR, TP53
15thymidylate469.6EGFR, TP53
16docetaxel46 52 62 1212.6EGFR, TP53
17hpvs469.6TP53, KRT14
18egcg469.5TP53, EGFR
19mg 13246 6210.4EGFR, TP53
20curcumin469.2EGFR, TP53
21tamoxifen46 52 30 1212.0EGFR, KRT14, TP53
22vitamin a46 25 1211.0KRT4, KRT14
23paraffin469.0EGFR, KRT14, TP53
24cisplatin46 52 62 1212.0TP53, KRT14, EGFR
25arginine468.9TP53, B3GAT1, KRT14
26retinoid468.4TP53, KRT14, KRT4, EGFR
27retinoic acid46 259.4EGFR, KRT4, KRT14, TP53
28progesterone46 30 62 25 1211.9EGFR, KRT4, KRT14, B3GAT1, TP53
29estrogen467.9TP53, B3GAT1, KRT14, KRT4, EGFR

GO Terms for genes affiliated with Basaloid Squamous Cell Carcinoma

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17Gene Ontology
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Cellular components related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0KRT4, KRT14
2keratin filamentGO:0450958.7KRT4, KRT14

Biological processes related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to drugGO:0356909.2EGFR, TP53
2epithelial cell differentiationGO:0308559.0KRT4, KRT14

Molecular functions related to Basaloid Squamous Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.5EGFR, TP53

Products for genes affiliated with Basaloid Squamous Cell Carcinoma

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Sources for Basaloid Squamous Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet