MCID: BSL004
MIFTS: 36

Basilar Artery Occlusion malady

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Basilar Artery Occlusion

Aliases & Descriptions for Basilar Artery Occlusion:

Name: Basilar Artery Occlusion 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:13446
ICD10 33 I65.1
ICD9CM 35 433.0
UMLS 69 C0265098

Summaries for Basilar Artery Occlusion

MalaCards based summary : Basilar Artery Occlusion is related to unverricht-lundborg syndrome and inferolateral myocardial infarct. An important gene associated with Basilar Artery Occlusion is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Cilostazol and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are hematopoietic system and respiratory system

Related Diseases for Basilar Artery Occlusion

Diseases related to Basilar Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 unverricht-lundborg syndrome 10.3 APOBEC3G PLAT
2 inferolateral myocardial infarct 10.2 ITGA2B PLAT
3 linear scleroderma 10.2 PLAT PLG
4 thunderclap headache 10.2 F2 ITGA2B
5 peanut allergy 10.2 F2 PLAT
6 colonic lymphangioma 10.2 ITGA2B PLG
7 hemarthrosis 10.1 F2 PLG
8 clear cell chondrosarcoma 10.1 ITGA2B PLG
9 miller-dieker lissencephaly syndrome 10.1 F2 PLG
10 cervix small cell carcinoma 10.1 F2 ITGA2B PLAT
11 influenza 10.1 F2 PLG
12 mixed epithelial tumor of ovary 10.1 F2 PLG
13 chronic fatigue syndrome 10.1 PLAT PLG
14 chorioretinal scar 10.1 F2 PLG
15 mixed hepatoblastoma 10.1 F2 PLG
16 alcoholic gastritis 10.1 F2 PLAT PLG
17 aneurysm 10.1
18 pregnancy loss, recurrent 1 10.1 F2 PLAT PLG
19 ocular hyperemia 10.0 F2 ITGA2B PLG
20 schwannoma of jugular foramen 10.0 F2 PLG
21 cerebritis 10.0
22 xeroderma pigmentosum, group b 10.0 ARRB1 ARRB2
23 midline cystocele 10.0 F2 PLG
24 thrombosis 10.0
25 ischemia 10.0
26 budd-chiari syndrome 9.9 F2 PLAT PLG TSPAN33
27 seminoma 9.9 F2 PLG
28 acute myocardial infarction 9.9
29 pontine hemorrhage 9.9
30 cervicitis 9.9
31 myocardial infarction 9.9
32 mutism 9.9
33 mobitz type ii atrioventricular block 9.7 F2 FOSB PLG SLC25A16
34 central nervous system vasculitis 9.7
35 burns 9.7
36 vasculitis 9.7
37 hydrocephalus 9.7
38 meningitis 9.7
39 muscular dystrophy 9.7
40 cryptococcal meningitis 9.7
41 arteriovenous malformation 9.7
42 vertebral artery occlusion 9.7
43 headache 9.7
44 choroiditis 9.7
45 cortical blindness 9.7
46 locked-in syndrome 9.7
47 syphilis 9.7
48 duchenne muscular dystrophy 9.7
49 akinetic mutism 9.7
50 coccidioidomycosis 8.2 APOBEC3G ARRB1 ARRB2 F2 FOSB ITGA2B

Graphical network of the top 20 diseases related to Basilar Artery Occlusion:



Diseases related to Basilar Artery Occlusion

Symptoms & Phenotypes for Basilar Artery Occlusion

MGI Mouse Phenotypes related to Basilar Artery Occlusion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 ARRB1 ARRB2 F2 ITGA2B PANX1 PLAT
2 respiratory system MP:0005388 9.1 ARRB1 ARRB2 F2 PANX1 PLAT PLG

Drugs & Therapeutics for Basilar Artery Occlusion

Drugs for Basilar Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cilostazol Approved Phase 4 73963-72-1 2754
2
Ticlopidine Approved Phase 4 55142-85-3 5472
3
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
4 Anti-Asthmatic Agents Phase 4
5 Autonomic Agents Phase 4
6 Bronchodilator Agents Phase 4
7 Cytochrome P-450 Enzyme Inhibitors Phase 4
8 Fibrinolytic Agents Phase 4,Phase 2
9 Neuroprotective Agents Phase 4
10 Neurotransmitter Agents Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Phosphodiesterase 3 Inhibitors Phase 4
13 Phosphodiesterase Inhibitors Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15 Protective Agents Phase 4
16 Purinergic P2 Receptor Antagonists Phase 4
17 Purinergic P2Y Receptor Antagonists Phase 4
18 Respiratory System Agents Phase 4
19 Vasodilator Agents Phase 4
20 Tissue Plasminogen Activator Phase 3
21 Plasminogen Phase 2
22 Anesthetics
23 Central Nervous System Depressants

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4
2 Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis II Completed NCT00130039 Phase 4
3 Basilar Artery International Cooperation Study Recruiting NCT01717755 Phase 3
4 Intra-arterial Microplasmin Administration in Patients With Acute Intracranial Vertebrobasilar Artery Occlusion Terminated NCT00123266 Phase 2
5 Multi MERCI (Mechanical Embolus Removal in Cerebral Ischemia [MERCIā„¢]) Completed NCT00318071
6 Basilar Artery Occlusion Chinese Endovascular Trial Recruiting NCT02737189
7 Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment Recruiting NCT02441556
8 Chinese Registry of Assisted Embolization for Unruptured Wide Necked Intracranial Aneurysm Using LVIS Stent Recruiting NCT02830373
9 Variation of Cerebral Blood Flow in Anterior Cerebral and Basilar Artery in Neonates and Infants in Genreal Anesthesia With Caudal Block Enrolling by invitation NCT02761954

Search NIH Clinical Center for Basilar Artery Occlusion

Genetic Tests for Basilar Artery Occlusion

Anatomical Context for Basilar Artery Occlusion

MalaCards organs/tissues related to Basilar Artery Occlusion:

39
Brain

Publications for Basilar Artery Occlusion

Articles related to Basilar Artery Occlusion:

(show top 50) (show all 265)
id Title Authors Year
1
Intra-arterial Treatment for Basilar Artery Occlusion. ( 27893872 )
2017
2
Intra-arterial Treatment for Basilar Artery Occlusion-Reply. ( 27893877 )
2017
3
A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study. ( 27257830 )
2016
4
Successful recanalization in acute basilar artery occlusion treated with endovascular therapy is independent of thrombus length. ( 27789788 )
2016
5
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT. ( 27068722 )
2016
6
Revascularization of acute basilar artery occlusion using theA Tigertriever adjustable clot retriever. ( 27511204 )
2016
7
Cocaine and Acute Basilar Artery Occlusion: What we Know to Date? ( 27633287 )
2016
8
Neurologic Examination at 24 to 48 Hours Predicts Functional Outcomes in Basilar Artery Occlusion Stroke. ( 27586683 )
2016
9
The challenge of basilar artery occlusion wake-up stroke: too late for intravenous thrombolysis? ( 26960980 )
2016
10
Mechanical thrombectomy in acute basilar artery occlusion: A safety and efficacy single centre study. ( 26908588 )
2016
11
Treatment of a Giant Fusiform Basilar Aneurysm with Partial Intra-Aneurysmal Embolization Combined with Mid-Basilar Artery Occlusion in a Child. ( 27116216 )
2016
12
Thrombectomy using a stent retriever with artificially induced vertebral artery vasospasm in a patient with acute basilar artery occlusion: a case report. ( 26678752 )
2016
13
Collateral flow predicts outcome after basilar artery occlusion: The posterior circulation collateral score. ( 27016515 )
2016
14
Acute Ischemic Stroke Involving Both Anterior and Posterior Circulation Treated by Endovascular Revascularization for Acute Basilar Artery Occlusion via Persistent Primitive Trigeminal Artery. ( 27446523 )
2016
15
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27799374 )
2016
16
Endovascular mechanical thrombectomy in basilar artery occlusion: variables affecting recanalization and outcome. ( 26872664 )
2016
17
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27797875 )
2016
18
Functional Independence following Endovascular Treatment for Basilar Artery Occlusion despite Extensive Bilateral Pontine Infarcts on Diffusion-Weighted Imaging: Refuting a Self-Fulfilling Prophecy. ( 27781047 )
2016
19
Safety and Outcome of Intra-Arterial Treatment for Basilar Artery Occlusion. ( 27532477 )
2016
20
Coil Embolization for Ruptured Basilar Tip Aneurysm After Mechanical Thrombectomy for Acute Basilar Artery Occlusion. ( 27368502 )
2016
21
Thrombectomy using Trevo ProVue Stent Retriever Devices after Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Basilar Artery Occlusion during Vertebral Artery Dissection. ( 27086817 )
2016
22
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT. ( 27075484 )
2016
23
Mechanical thrombectomy with the Solitaire AB stent for treatment of acute basilar artery occlusion: A single-center experience. ( 27312281 )
2016
24
Intra-arterial revascularization therapy for basilar artery occlusion-a systematic review and analysis. ( 26810313 )
2016
25
Endovascular Mechanical Thrombectomy with the Solitaire Device for the Treatment of Acute Basilar Artery Occlusion. ( 26875658 )
2016
26
A Comparison between Mechanical Thrombectomy and Intra-arterial Fibrinolysis in Acute Basilar Artery Occlusion: Single Center Experiences. ( 27283281 )
2016
27
Outcomes of stent retriever thrombectomy in basilar artery occlusion: an observational study and systematic review. ( 25986363 )
2015
28
Posterior Circulation Acute Stroke Prognosis Early Computed Tomography Score Using Hypointense Vessels on Susceptibility Weighted Imaging Independently Predicts Outcome in Patients with Basilar Artery Occlusion. ( 26176682 )
2015
29
Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever. ( 26156170 )
2015
30
Significant period between presentation and diagnosis in basilar artery occlusion: five cases and the lessons learned. ( 25721014 )
2015
31
Infarction of the choroid plexus in basilar artery occlusion. ( 26299694 )
2015
32
Different Imaging Strategies in Patients With Possible Basilar Artery Occlusion: Cost-Effectiveness Analysis. ( 26022634 )
2015
33
Predictors of Good Outcome After Stent-Retriever Thrombectomy in Acute Basilar Artery Occlusion. ( 26330448 )
2015
34
A novel route of revascularization in basilar artery occlusion and review of the literature. ( 26055597 )
2015
35
Basilar artery occlusion: Prognostic signs of severity on computed tomography. ( 25857713 )
2015
36
Initial factors affecting the clinical outcome after successful recanalization via MR-based mechanical thrombectomy in patients with acute ischemic stroke due to basilar artery occlusion. ( 26371295 )
2015
37
Recanalization of basilar artery occlusion. ( 26219271 )
2015
38
Endovascular treatment of severe acute basilar artery occlusion. ( 25443091 )
2015
39
A novel route of revascularization in basilar artery occlusion and review of the literature. ( 26063797 )
2015
40
Time window for recanalization in basilar artery occlusion: Speculative synthesis. ( 26574535 )
2015
41
Acute basilar artery occlusion: an easily missed uncommon but devastating emergency. ( 26238141 )
2015
42
Endovascular treatment of acute basilar artery occlusion: time to treatment is crucial. ( 25703459 )
2015
43
Posterior circulation CT angiography collaterals predict outcome of endovascular acute ischemic stroke therapy for basilar artery occlusion. ( 26283714 )
2015
44
Outcomes of endovascular treatment of basilar artery occlusion in the stent retriever era: a systematic review and meta-analysis. ( 26610730 )
2015
45
Acute ischemic stroke in a child due to basilar artery occlusion treated successfully with a stent retriever. ( 26150626 )
2015
46
Prodromal Transient Ischemic Attack or Minor Stroke and Outcome in Basilar Artery Occlusion. ( 26153508 )
2015
47
Endovascular revascularization for basilar artery occlusion. ( 25999990 )
2015
48
The use of mechanical thrombectomy in the treatment of basilar artery occlusion--case report. ( 26377986 )
2015
49
Mechanical recanalization in basilar artery occlusion: the ENDOSTROKE study. ( 25516154 )
2015
50
Symptomatic intracranial haemorrhage after thrombolysis with adjuvant anticoagulation in basilar artery occlusion. ( 25482105 )
2015

Variations for Basilar Artery Occlusion

Expression for Basilar Artery Occlusion

Search GEO for disease gene expression data for Basilar Artery Occlusion.

Pathways for Basilar Artery Occlusion

Pathways related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 ARRB1 ARRB2 F2 ITGA2B PLAT PLG
2
Show member pathways
11.86 F2 PLAT PLG
3
Show member pathways
11.84 ARRB1 ARRB2 F2
4 11.72 F2 PLAT PLG
5
Show member pathways
11.68 ARRB1 ARRB2 ITGA2B
6 11.1 ARRB1 ARRB2 FOSB
7 11 F2 PLG
8 10.96 ARRB2 SLC12A3
9 10.85 PLAT PLG
10 10.73 ARRB1 ARRB2 FOSB
11 10.64 F2 PLG
12 10.27 PLAT PLG

GO Terms for Basilar Artery Occlusion

Cellular components related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.32 ARRB1 ARRB2 F2 ITGA2B PANX1 PLG

Biological processes related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.61 ARRB1 ARRB2 F2
2 platelet activation GO:0030168 9.5 ARRB1 ARRB2 F2
3 negative regulation of interleukin-6 production GO:0032715 9.46 ARRB1 ARRB2
4 negative regulation of proteolysis GO:0045861 9.4 F2 PLAT
5 positive regulation of receptor internalization GO:0002092 9.37 ARRB1 ARRB2
6 G-protein coupled receptor internalization GO:0002031 9.26 ARRB1 ARRB2
7 negative regulation of fibrinolysis GO:0051918 9.16 F2 PLG
8 follicle-stimulating hormone signaling pathway GO:0042699 8.96 ARRB1 ARRB2
9 fibrinolysis GO:0042730 8.8 F2 PLAT PLG

Molecular functions related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.72 ARRB2 F2 PANX1 PLAT PLG
2 serine-type peptidase activity GO:0008236 9.54 F2 PLAT PLG
3 alpha-1B adrenergic receptor binding GO:0031692 9.26 ARRB1 ARRB2
4 angiotensin receptor binding GO:0031701 9.16 ARRB1 ARRB2
5 alpha-1A adrenergic receptor binding GO:0031691 8.96 ARRB1 ARRB2
6 follicle-stimulating hormone receptor binding GO:0031762 8.62 ARRB1 ARRB2

Sources for Basilar Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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