MCID: BSL004
MIFTS: 35

Basilar Artery Occlusion

Categories: Cardiovascular diseases

Aliases & Classifications for Basilar Artery Occlusion

MalaCards integrated aliases for Basilar Artery Occlusion:

Name: Basilar Artery Occlusion 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:13446
ICD10 32 I65.1
ICD9CM 34 433.0
UMLS 69 C0265098

Summaries for Basilar Artery Occlusion

MalaCards based summary : Basilar Artery Occlusion is related to acute myocardial infarction and vertebral artery occlusion. An important gene associated with Basilar Artery Occlusion is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and ADP signalling through P2Y purinoceptor 1. The drug Tissue Plasminogen Activator has been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is respiratory system.

Related Diseases for Basilar Artery Occlusion

Diseases related to Basilar Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.3 ITGA2B PLAT PLG
2 vertebral artery occlusion 29.9 FOSB PLG SLC25A16
3 ligneous conjunctivitis 10.5 PLAT PLG
4 inferior myocardial infarction 10.5 PLAT PLG
5 brain stem infarction 10.5 APOBEC3G PLG
6 central retinal artery occlusion 10.5 PLAT PLG
7 lateral myocardial infarction 10.4 ITGA2B PLG
8 occlusion precerebral artery 10.4 PLAT PLG
9 cerebral falx meningioma 10.4 F2 PLG
10 intestinal impaction 10.4 F2 PLG
11 leech infestation 10.4 F2 PLG
12 intracranial vasospasm 10.4 PLAT TSPAN33
13 alpha-2-plasmin inhibitor deficiency 10.4 F2 PLG
14 giant hemangioma 10.4 F2 PLG
15 blue toe syndrome 10.3 F2 PLG
16 femoral neuropathy 10.3 F2 PLG
17 anterior cranial fossa meningioma 10.3 F2 PLG
18 carotid artery thrombosis 10.3 ITGA2B PLAT
19 anterior spinal artery syndrome 10.3 F2 PLG
20 marantic endocarditis 10.3 F2 PLAT
21 acute cor pulmonale 10.3 PLAT PLG
22 intermediate coronary syndrome 10.3 ITGA2B PLAT PLG
23 korean hemorrhagic fever 10.3 F2 PLG
24 intracranial embolism 10.2 F2 PLAT PLG
25 vein disease 10.2 F2 PLAT PLG
26 thrombophilia due to activated protein c resistance 10.2 F2 PLAT PLG
27 disseminated intravascular coagulation 10.2 F2 PLAT PLG
28 lemierre's syndrome 10.2 PLG SLC25A16
29 retinal vascular occlusion 10.2 F2 PLG
30 aneurysm 10.2
31 cerebritis 10.2
32 thrombophilia 10.1 F2 PLAT PLG
33 blood coagulation disease 10.1 F2 ITGA2B PLG
34 hemorrhagic disease 10.1 F2 ITGA2B PLAT
35 inherited blood coagulation disease 10.1 F2 ITGA2B
36 cerebrovascular disease 10.1 F2 ITGA2B PLAT
37 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.0
38 thrombosis 10.0
39 ischemia 10.0
40 thrombophlebitis 10.0 F2 PLAT
41 acute pulmonary heart disease 10.0 PLAT PLG
42 subdural empyema 10.0 FOSB TSPAN33
43 arteries, anomalies of 10.0 F2 ITGA2B PLAT PLG
44 branchiootic syndrome 1 10.0
45 myocardial infarction 10.0
46 cervicitis 10.0
47 mutism 10.0
48 pontine hemorrhage 10.0
49 stroke, ischemic 9.9 F2 PLAT PLG TSPAN33
50 migraine with or without aura 1 9.8

Graphical network of the top 20 diseases related to Basilar Artery Occlusion:



Diseases related to Basilar Artery Occlusion

Symptoms & Phenotypes for Basilar Artery Occlusion

MGI Mouse Phenotypes related to Basilar Artery Occlusion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.1 ARRB1 ARRB2 F2 PANX1 PLAT PLG

Drugs & Therapeutics for Basilar Artery Occlusion

Drugs for Basilar Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tissue Plasminogen Activator

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Basilar Artery Occlusion Chinese Endovascular Trial Recruiting NCT02737189 Medical Treatment
2 Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment Recruiting NCT02441556
3 Basilar Artery International Cooperation Study Recruiting NCT01717755

Search NIH Clinical Center for Basilar Artery Occlusion

Genetic Tests for Basilar Artery Occlusion

Anatomical Context for Basilar Artery Occlusion

MalaCards organs/tissues related to Basilar Artery Occlusion:

38
Brain

Publications for Basilar Artery Occlusion

Articles related to Basilar Artery Occlusion:

(show top 50) (show all 290)
# Title Authors Year
1
The Basilar Artery on Computed Tomography Angiography Score for Acute Basilar Artery Occlusion Treated with Mechanical Thrombectomy. ( 29422378 )
2018
2
Predictors for Mortality after Mechanical Thrombectomy of Acute Basilar Artery Occlusion. ( 29393092 )
2018
3
Mechanical thrombectomy in basilar artery occlusion: influence of reperfusion on clinical outcome and impact of the first-line strategy (ADAPT vs stent retriever). ( 29327997 )
2018
4
Correction to: Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is a Predictor of Favorable Clinical Outcome. ( 29318351 )
2018
5
Intra-arterial Treatment for Basilar Artery Occlusion. ( 27893872 )
2017
6
Child Neurology: Childhood basilar artery occlusion and stroke. ( 28808172 )
2017
7
Multimodal Therapy for Non-Superacute Vertebral Basilar Artery Occlusion. ( 29118803 )
2017
8
Acute superior mesenteric artery occlusion complicated by basilar artery occlusion. ( 28828111 )
2017
9
Efficacy and safety of direct aspiration first pass technique versus stent-retriever thrombectomy in acute basilar artery occlusion-a retrospective single center experience. ( 28251328 )
2017
10
Hybrid Retrograde-Antegrade Recanalization of Acute Basilar Artery Occlusion. ( 29118804 )
2017
11
Dominant vertebral artery status and functional outcome after endovascular therapy of symptomatic basilar artery occlusion. ( 28131432 )
2017
12
Acute basilar artery occlusion: Endovascular Interventions versus Standard Medical Treatment (BEST) Trial-Design and protocol for a randomized, controlled, multicenter study. ( 28361616 )
2017
13
Late recanalization of basilar artery occlusion in a previously healthy 17-month-old child. ( 29030498 )
2017
14
Concomitant carotid aplasia and basilar artery occlusion in a child with PHACES syndrome. ( 28814594 )
2017
15
The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion. ( 28228577 )
2017
16
Effectiveness and Safety of Mechanical Thrombectomy with Stent Retrievers in Basilar Artery Occlusion: Comparison with Anterior Circulation Occlusions. ( 29142622 )
2017
17
Treatment of acute basilar artery occlusion: Systematic review and meta-analysis. ( 28823413 )
2017
18
Neuroimaging Predictors of Clinical Outcome in Acute Basilar Artery Occlusion. ( 28674517 )
2017
19
Acute Basilar Artery Occlusion: Differences in Characteristics and Outcomes after Endovascular Therapy between Patients with and without Underlying Severe Atherosclerotic Stenosis. ( 28546252 )
2017
20
Mechanical Thrombectomy for Acute Basilar Artery Occlusion in Early Therapeutic Time Window. ( 28848166 )
2017
21
The efficiency analysis of thrombolytic rt-PA combined with intravascular interventional therapy in patients with acute basilar artery occlusion. ( 28123346 )
2017
22
Clinical Outcomes of Patients with Acute Basilar Artery Occlusion in Brazil: An Observational Study. ( 28551292 )
2017
23
ADC quantification in basilar artery occlusion as an indicator of clinical outcome after endovascular treatment. ( 28699370 )
2017
24
Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion. ( 29160168 )
2017
25
Intra-arterial Treatment for Basilar Artery Occlusion-Reply. ( 27893877 )
2017
26
Mechanical Thrombectomy in Basilar Artery Occlusion : Presence of Bilateral Posterior Communicating Arteries is aA Predictor of Favorable Clinical Outcome. ( 29260256 )
2017
27
Coil Embolization for Ruptured Basilar Tip Aneurysm After Mechanical Thrombectomy for Acute Basilar Artery Occlusion. ( 27368502 )
2016
28
Neurologic Examination at 24 to 48 Hours Predicts Functional Outcomes in Basilar Artery Occlusion Stroke. ( 27586683 )
2016
29
Acute Ischemic Stroke Involving Both Anterior and Posterior Circulation Treated by Endovascular Revascularization for Acute Basilar Artery Occlusion via Persistent Primitive Trigeminal Artery. ( 27446523 )
2016
30
Endovascular Mechanical Thrombectomy with the Solitaire Device for the Treatment of Acute Basilar Artery Occlusion. ( 26875658 )
2016
31
Thrombectomy using Trevo ProVue Stent Retriever Devices after Recombinant Tissue Plasminogen Activator Thrombolysis for Acute Basilar Artery Occlusion during Vertebral Artery Dissection. ( 27086817 )
2016
32
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27797875 )
2016
33
Functional Independence following Endovascular Treatment for Basilar Artery Occlusion despite Extensive Bilateral Pontine Infarcts on Diffusion-Weighted Imaging: Refuting a Self-Fulfilling Prophecy. ( 27781047 )
2016
34
Cocaine and Acute Basilar Artery Occlusion: What we Know to Date? ( 27633287 )
2016
35
Revascularization of acute basilar artery occlusion using theA Tigertriever adjustable clot retriever. ( 27511204 )
2016
36
Thrombectomy using a stent retriever with artificially induced vertebral artery vasospasm in a patient with acute basilar artery occlusion: a case report. ( 26678752 )
2016
37
Safety and Outcome of Intra-Arterial Treatment for Basilar Artery Occlusion. ( 27532477 )
2016
38
The challenge of basilar artery occlusion wake-up stroke: too late for intravenous thrombolysis? ( 26960980 )
2016
39
Intra-arterial revascularization therapy for basilar artery occlusion-a systematic review and analysis. ( 26810313 )
2016
40
Treatment of a Giant Fusiform Basilar Aneurysm with Partial Intra-Aneurysmal Embolization Combined with Mid-Basilar Artery Occlusion in a Child. ( 27116216 )
2016
41
Ruptured aneurysm at the cortical segment of the distal posterior inferior cerebellar artery associated with hemodynamic stress after basilar artery occlusion. ( 28144485 )
2016
42
Mechanical thrombectomy with the Solitaire AB stent for treatment of acute basilar artery occlusion: A single-center experience. ( 27312281 )
2016
43
Successful recanalization in acute basilar artery occlusion treated with endovascular therapy is independent of thrombus length. ( 27789788 )
2016
44
Endovascular mechanical thrombectomy in basilar artery occlusion: variables affecting recanalization and outcome. ( 26872664 )
2016
45
Mechanical thrombectomy in acute basilar artery occlusion: A safety and efficacy single centre study. ( 26908588 )
2016
46
A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study. ( 27257830 )
2016
47
A Comparison between Mechanical Thrombectomy and Intra-arterial Fibrinolysis in Acute Basilar Artery Occlusion: Single Center Experiences. ( 27283281 )
2016
48
Collateral flow predicts outcome after basilar artery occlusion: The posterior circulation collateral score. ( 27016515 )
2016
49
Basilar artery occlusion in a child treated successfully with mechanical thrombectomy using ADAPT. ( 27075484 )
2016
50
Where did the clot go? An unusual complication of mechanical thrombectomy caused by malignancy related subclavian steal phenomenon in a patient with acute basilar artery occlusion. ( 27799374 )
2016

Variations for Basilar Artery Occlusion

Expression for Basilar Artery Occlusion

Search GEO for disease gene expression data for Basilar Artery Occlusion.

Pathways for Basilar Artery Occlusion

Pathways related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 ARRB1 ARRB2 F2 ITGA2B PLAT PLG
2
Show member pathways
11.86 ARRB1 ARRB2 F2
3
Show member pathways
11.83 F2 PLAT PLG
4 11.72 F2 PLAT PLG
5
Show member pathways
11.68 ARRB1 ARRB2 ITGA2B
6 11.1 ARRB1 ARRB2 FOSB
7 11 F2 PLG
8 10.96 ARRB2 SLC12A3
9 10.79 PLAT PLG
10 10.7 ARRB1 ARRB2 FOSB
11 10.64 F2 PLG
12 10.27 PLAT PLG

GO Terms for Basilar Artery Occlusion

Cellular components related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.32 ARRB1 ARRB2 F2 ITGA2B OXTR PANX1

Biological processes related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.63 ARRB1 ARRB2 F2
2 platelet activation GO:0030168 9.5 ARRB1 ARRB2 F2
3 negative regulation of interleukin-6 production GO:0032715 9.43 ARRB1 ARRB2
4 negative regulation of proteolysis GO:0045861 9.4 F2 PLAT
5 positive regulation of receptor internalization GO:0002092 9.37 ARRB1 ARRB2
6 G-protein coupled receptor internalization GO:0002031 9.26 ARRB1 ARRB2
7 negative regulation of fibrinolysis GO:0051918 9.16 F2 PLG
8 follicle-stimulating hormone signaling pathway GO:0042699 8.96 ARRB1 ARRB2
9 fibrinolysis GO:0042730 8.8 F2 PLAT PLG

Molecular functions related to Basilar Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.72 ARRB2 F2 PANX1 PLAT PLG
2 serine-type peptidase activity GO:0008236 9.58 F2 PLAT PLG
3 arrestin family protein binding GO:1990763 9.37 ARRB1 ARRB2
4 alpha-1B adrenergic receptor binding GO:0031692 9.26 ARRB1 ARRB2
5 angiotensin receptor binding GO:0031701 9.16 ARRB1 ARRB2
6 alpha-1A adrenergic receptor binding GO:0031691 8.96 ARRB1 ARRB2
7 follicle-stimulating hormone receptor binding GO:0031762 8.62 ARRB1 ARRB2

Sources for Basilar Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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