BMD
MCID: BCK001
MIFTS: 62

Becker Muscular Dystrophy (BMD) malady

Genetic diseases, Rare diseases, Neuronal diseases, Muscle diseases categories

Summaries for Becker Muscular Dystrophy

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OMIM:46 The muscular dystrophy that carries the Becker eponym is similar to Duchenne muscular dystrophy in the distribution of... (300376) more...

MalaCards based summary: Becker Muscular Dystrophy, also known as benign pseudohypertrophic muscular dystrophy, is related to muscular dystrophy and duchenne muscular dystrophy, and has symptoms including autosomal dominant inheritance, muscle weakness and abnormality of metabolism/homeostasis. An important gene associated with Becker Muscular Dystrophy is DMD (dystrophin). The compounds succinate and ornithine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related mouse phenotypes are vision/eye and muscle.

NIH Rare Diseases:42 Becker muscular dystrophy (bmd) is an inherited condition that primarily affects males and causes progressive weakness and wasting of the skeletal and cardiac (heart) muscles. the age of onset and rate of progression can vary among affected people. muscle weakness usually becomes apparent between the ages of 5 and 15. in some cases, heart involvement (cardiomyopathy) is the first sign. bmd is caused by a mutation in the dmd gene and is inherited in an x-linked recessive manner. bmd is very similar to duchenne muscular dystrophy, except that symptoms begin later and progress at a slower rate. there is no cure for this condition, and treatment aims to relieve symptoms to help quality of life. people with bmd may survive into their 40s or beyond. last updated: 3/5/2014

Description from OMIM:46 159050

Aliases & Classifications for Becker Muscular Dystrophy

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Sources:
31LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 46OMIM, 11DISEASES, 48Orphanet, 61UMLS, 21GeneTests, 23GTR, 44Novoseek, 28ICD9CM, 56SNOMED-CT, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Becker Muscular Dystrophy, Aliases & Descriptions:

Name: Becker Muscular Dystrophy 31 9 10 42 46 11 48 61
Benign Pseudohypertrophic Muscular Dystrophy 9 42 61
Muscular Dystrophy, Becker Type 42 21 23
Benign Congenital Myopathy 9 61
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type 42
 
Becker's Muscular Dystrophy 42
Muscular Dystrophy Becker 44
Becker Dystrophinopathy 48
Bmd 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Muscle diseases


Characteristics (Orphanet epidemiological data):

48
becker muscular dystrophy:
Inheritance: X-linked recessive; Prevalence: 1-9/100000; Age of onset: Childhood; Age of death: Any age


External Ids:

Disease Ontology9 DOID:9883
ICD9CM28 359.0
MESH via Orphanet35 C537666
ICD10 via Orphanet27 G71.0
UMLS via Orphanet62 C0917713

Related Diseases for Becker Muscular Dystrophy

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Diseases related to Becker Muscular Dystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1muscular dystrophy32.3CHKB, FKRP, DMD
2duchenne muscular dystrophy31.3CHKB, DMD
3myopathy30.9CHKB, FKRP, DMD
4limb-girdle muscular dystrophy30.9FKRP, DMD
5myotonic dystrophy30.9DMD, CHKB
6dilated cardiomyopathy30.8DMD, FKRP, CHKB
7myositis30.7DMD, CHKB
8neuromuscular disease30.6DMD, CHKB
9neuropathy30.4DMD, FKRP
10mental retardation30.4FKRP, DMD
11noonan syndrome30.3CHKB, FKRP, DMD
12muscular dystrophy, duchenne and becker types10.7
13spinal muscular atrophy10.6
14muscular atrophy10.6
15malignant hyperthermia10.5
16osteoporosis10.5
17gas gangrene10.4DMD
18klinefelter's syndrome10.4
19ischemia10.4
20myotonia10.4
21centronuclear myopathy10.4DMD
22osteoporotic fracture10.3
23arthritis10.3
24celiac disease10.3
25facioscapulohumeral muscular dystrophy10.3
26hodgkin's lymphoma10.3
27liver disease10.3
28schizophrenia10.3
29angelman syndrome10.3
30wolff-parkinson-white syndrome10.3
31fatty liver disease10.3
32myotonic dystrophy type 110.3
33bethlem myopathy10.3
34neuronitis10.3
35cerebritis10.3
36atrioventricular block10.3
37sleep apnea10.3
38mitochondrial disorders10.3
39growth hormone deficiency10.3
40left ventricular noncompaction10.3
41nondystrophic myotonia10.3
42sarcoglycanopathies10.3
43pulmonary function10.3
44focal myositis10.3
45distal muscular dystrophy10.2DMD, CHKB
46anorexia nervosa10.2
47myopathy congenital10.2DMD, CHKB
48turner syndrome10.2DMD, SHOX
49limb-girdle muscular dystrophy, type 2g10.2FKRP, DMD
50muscular dystrophy-dystroglycanopathy , type a, 110.2DMD, FKRP

Graphical network of the top 20 diseases related to Becker Muscular Dystrophy:



Diseases related to becker muscular dystrophy

Symptoms for Becker Muscular Dystrophy

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Symptoms by clinical synopsis from OMIM:

159050

Clinical features from OMIM:

300376,159050

HPO human phenotypes related to Becker Muscular Dystrophy:

(show all 13)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 muscle weakness HP:0001324
3 abnormality of metabolism/homeostasis HP:0001939
4 muscular dystrophy HP:0003560
5 hyporeflexia HP:0001265
6 muscle weakness HP:0001324
7 x-linked recessive inheritance HP:0001419
8 cardiomyopathy HP:0001638
9 elevated serum creatine phosphokinase HP:0003236
10 myalgia HP:0003326
11 adult onset HP:0003581
12 calf muscle pseudohypertrophy HP:0003707
13 arrhythmia HP:0011675

Drugs & Therapeutics for Becker Muscular Dystrophy

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Drug clinical trials:

Search ClinicalTrials for Becker Muscular Dystrophy

Search NIH Clinical Center for Becker Muscular Dystrophy

Genetic Tests for Becker Muscular Dystrophy

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Genetic tests related to Becker Muscular Dystrophy:

id Genetic test Affiliating Genes
1 Becker Muscular Dystrophy21 23

Anatomical Context for Becker Muscular Dystrophy

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MalaCards organs/tissues related to Becker Muscular Dystrophy:

32
Heart, Testes, Brain, Skeletal muscle, Bone, Colon, Liver

Animal Models for Becker Muscular Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Becker Muscular Dystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6FKRP, MYF6, DMD
2MP:00053698.1CHKB, FKRP, MYF6, DMD
3MP:00053908.0DMD, MYF6, FKRP, CHKB
4MP:00053767.8CHKB, FKRP, MYF6, DMD

Publications for Becker Muscular Dystrophy

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Articles related to Becker Muscular Dystrophy:

(show top 50)    (show all 459)
idTitleAuthorsYear
1
Duchenne/Becker muscular dystrophy: A report on clinical, biochemical, and genetic study in Gujarat population, India. (25221400)
2014
2
Genetic testing for Duchenne/Becker muscular dystrophy in Johannesburg, South Africa. (24300647)
2013
3
Prognosis of Duchenne/Becker muscular dystrophy with noncompaction is worse than without noncompaction. (23639464)
2013
4
Genetic analysis of dystrophin gene for affected male and female carriers with Duchenne/Becker muscular dystrophy in Korea. (22379338)
2012
5
Novel mutation in spectrin-like repeat 1 of dystrophin central domain causes protein misfolding and mild Becker muscular dystrophy. (22453924)
2012
6
Prenatal diagnosis of Duchenne/Becker muscular dystrophy by short tandem repeat segregation analysis in Argentine families. (21305566)
2011
7
Becker muscular dystrophy patients with deletions around exon 51; a promising outlook for exon skipping therapy in Duchenne patients. (20153965)
2010
8
The 6-minute walk test in Duchenne/Becker muscular dystrophy: longitudinal observations. (21038378)
2010
9
Commentary on 'Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center'. (20555341)
2010
10
Cardiac involvement in Becker muscular dystrophy. (18841259)
2008
11
Life expectancy and death from cardiomyopathy amongst carriers of Duchenne and Becker muscular dystrophy in Scotland. (17932095)
2008
12
Patterns of dystrophin gene deletion in Egyptian Duchenne/Becker muscular dystrophy patients. (18646563)
2007
13
Valley sign in Becker muscular dystrophy and outliers of Duchenne and Becker muscular dystrophy. (15269471)
2004
14
Electroretinographic findings in Duchenne/Becker muscular dystrophy and correlation with genotype. (12324874)
2002
15
Carrier detection of Duchenne/Becker muscular dystrophy by analysis of STRs loci linked to the gene of dystrophin in Venezuelan families]. (12520997)
2002
16
Carrier detection and prenatal diagnosis in Duchenne/Becker muscular dystrophy. (11418728)
2001
17
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
18
Absence of brain Dp140 isoform and cognitive impairment in Becker muscular dystrophy. (10093987)
1999
19
Statistically significant differences in the number of CD24 positive muscle fibers and satellite cells between sarcoglycanopathy and age-matched Becker muscular dystrophy patients. (10397078)
1999
20
Genetic polymorphism in muscle biopsies of Duchenne and Becker muscular dystrophy patients. (10514583)
1999
21
Manifestations of Duchenne and Becker muscular dystrophy among carriers. (10541963)
1999
22
Deletion patterns in Argentine patients with Duchenne and Becker muscular dystrophy. (9664586)
1998
23
Pilot study of myoblast transfer in the treatment of Becker muscular dystrophy. (9710042)
1998
24
Epilepsy in Duchenne and Becker muscular dystrophies. (10728205)
1997
25
Cardiac function, metabolism and perfusion in Duchenne and Becker muscular dystrophy. (8887952)
1996
26
PCR techniques for deletion, linkage, and mutation analysis in duchenne/becker muscular dystrophy. (21374510)
1996
27
Accurate diagnosis of carriers of deletions and duplications in Duchenne/Becker muscular dystrophy by fluorescent dosage analysis. (8818939)
1996
28
An unusual association: celiac disease and Becker muscular dystrophy. (8678019)
1996
29
In utero fetal muscle biopsy alters diagnosis and carrier risks in Duchenne and Becker muscular dystrophy. (7794517)
1995
30
Variability in clinical, genetic and protein abnormalities in manifesting carriers of Duchenne and Becker muscular dystrophy. (8329890)
1993
31
Duchenne/Becker muscular dystrophy carrier detection using quantitative PCR and fluorescence-based strategies. (7510932)
1993
32
Effects of electrical stimulation on muscles of children with Duchenne and Becker muscular dystrophy. (8232775)
1993
33
Verification of carrier status for Becker muscular dystrophy from analysis of a blighted ovum. (8284293)
1993
34
Carrier detection of Duchenne/Becker muscular dystrophy: computer-assisted direct quantitation of gene amplification products. (1621929)
1992
35
Delayed expression of dystrophin on regenerating muscle from two siblings with Becker muscular dystrophy. (1506856)
1992
36
Dystrophin in frameshift deletion patients with Becker muscular dystrophy. (1496988)
1992
37
Carrier detection of Duchenne and Becker muscular dystrophy using muscle dystrophin immunohistochemistry. (1309152)
1992
38
Detection of Duchenne and Becker muscular dystrophy carriers by quantitative multiplex polymerase chain reaction analysis. (1513470)
1992
39
Dystrophin as a diagnostic marker in Duchenne and Becker muscular dystrophy. Correlation of immunofluorescence and western blot. (1944822)
1991
40
Analysis of Scottish Duchenne and Becker muscular dystrophy families with dystrophin cDNA probes. (2191136)
1990
41
Quadriceps myopathy: forme fruste of Becker muscular dystrophy. (2260849)
1990
42
An unusual variant of Becker muscular dystrophy. (2193611)
1990
43
Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies. (2261642)
1990
44
Dystrophin abnormalities in Duchenne/Becker muscular dystrophy. (2696500)
1989
45
Detection of Duchenne/Becker muscular dystrophy carriers by densitometric scanning. (2731350)
1989
46
The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion. (2491009)
1989
47
Direct method for prenatal diagnosis and carrier detection in Duchenne/Becker muscular dystrophy using the entire dystrophin cDNA. (2897793)
1988
48
The application of linkage analysis to genetic counselling in families with Duchenne or Becker muscular dystrophy. (3572997)
1987
49
Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy. (2993158)
1985
50
Definitive localization of Becker muscular dystrophy in Xp by linkage to a cluster of DNA polymorphisms (DXS43 and DXS9). (2993155)
1985

Variations for Becker Muscular Dystrophy

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UniProtKB/Swiss-Prot genetic disease variations for Becker Muscular Dystrophy:

63
id Symbol AA change Variation ID SNP ID
1DMDp.Ala168AspVAR_005149
2DMDp.Tyr231AsnVAR_005150
3DMDp.His2921ArgVAR_005170rs1800279
4DMDp.Ala3421ValVAR_005172
5DMDp.Ala171ProVAR_023539

Clinvar genetic disease variations for Becker Muscular Dystrophy:

7 (show all 14)
id Gene Name Type Significance SNP ID Assembly Location
1DMDDMD, IVS19, A-C, +3single nucleotide variantPathogenic
2DMDDMD, IVS57, G-C, -1single nucleotide variantPathogenic
3DMDNM_004006.2(DMD): c.503C> A (p.Ala168Asp)single nucleotide variantPathogenicrs128626236GRCh37Chr X, 32834612: 32834612
4DMDDMD, IVS2, G-T, -1single nucleotide variantPathogenic
5DMDNM_004006.2(DMD): c.691T> A (p.Tyr231Asn)single nucleotide variantPathogenicrs128626237GRCh37Chr X, 32717369: 32717369
6DMDBMD, IVS13, G-T, -1single nucleotide variantPathogenic
7DMDNM_004006.2(DMD): c.8762A> G (p.His2921Arg)single nucleotide variantPathogenicrs1800279GRCh37Chr X, 31496398: 31496398
8DMDNM_004006.2(DMD): c.10262C> T (p.Ala3421Val)single nucleotide variantPathogenicrs104894791GRCh37Chr X, 31196049: 31196049
9DMDDMD, 1-BP DEL, 10683CdeletionPathogenic
10DMDNM_004006.2(DMD): c.3631G> T (p.Glu1211Ter)single nucleotide variantPathogenicrs267606771GRCh37Chr X, 32466728: 32466728
11DMDNM_004006.2(DMD): c.3940C> T (p.Arg1314Ter)single nucleotide variantPathogenicrs5030730GRCh37Chr X, 32456489: 32456489
12DMDNM_004006.2(DMD): c.9225-285A> Gsingle nucleotide variantPathogenicGRCh37Chr X, 31279418: 31279418
13DMDDMD, IVS25, A-G, +2036single nucleotide variantPathogenic
14DMDNM_004006.2(DMD): c.9G> A (p.Trp3Ter)single nucleotide variantPathogenicrs398122853GRCh37Chr X, 33229421: 33229421

Expression for genes affiliated with Becker Muscular Dystrophy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Becker Muscular Dystrophy patients vs. healthy controls: 31 (show all 188)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MYH3myosin, heavy chain 3, skeletal muscle, embryonicSkeletal Muscle+4.140.000
2MALAT1metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)Skeletal Muscle-2.870.000
3COL1A1collagen, type I, alpha 1Skeletal Muscle+2.850.000
4COL3A1collagen, type III, alpha 1Skeletal Muscle+2.650.000
5COL1A2collagen, type I, alpha 2Skeletal Muscle+2.580.000
6MYH8myosin, heavy chain 8, skeletal muscle, perinatalSkeletal Muscle+2.530.000
7S100A4S100 calcium binding protein A4Skeletal Muscle+2.390.000
8FRZBfrizzled-related proteinSkeletal Muscle+2.260.000
9DCLK1doublecortin-like kinase 1Skeletal Muscle+2.110.000
10LYZlysozymeSkeletal Muscle+2.090.000
11ACTC1actin, alpha, cardiac muscle 1Skeletal Muscle+2.060.000
12HLA-DPB1major histocompatibility complex, class II, DP beta 1Skeletal Muscle+2.020.000
13PRUNE2prune homolog 2 (Drosophila)Skeletal Muscle+2.000.000
14TIMP1TIMP metallopeptidase inhibitor 1Skeletal Muscle+1.970.000
15AQP4aquaporin 4Skeletal Muscle-1.960.000
16MYL5myosin, light chain 5, regulatorySkeletal Muscle+1.930.000
17PPP1R3Aprotein phosphatase 1, regulatory subunit 3ASkeletal Muscle-1.880.000
18CMYA5cardiomyopathy associated 5Skeletal Muscle-1.880.000
19CLIC4chloride intracellular channel 4Skeletal Muscle+1.870.000
20COL6A2collagen, type VI, alpha 2Skeletal Muscle+1.860.000
21NNMTnicotinamide N-methyltransferaseSkeletal Muscle+1.850.000
22THBS4thrombospondin 4Skeletal Muscle+1.830.000
23PPIBpeptidylprolyl isomerase B (cyclophilin B)Skeletal Muscle+1.820.000
24TUBA1Atubulin, alpha 1aSkeletal Muscle+1.800.000
25USO1USO1 vesicle transport factorSkeletal Muscle-1.790.000
26MXRA5matrix-remodelling associated 5Skeletal Muscle+1.760.000
27TUBB6tubulin, beta 6 class VSkeletal Muscle+1.740.000
28TUBB2Atubulin, beta 2A class IIaSkeletal Muscle+1.730.000
29CD44CD44 molecule (Indian blood group)Skeletal Muscle+1.730.000
30S100A11S100 calcium binding protein A11Skeletal Muscle+1.700.000
31ASPNasporinSkeletal Muscle+1.690.000
32COL6A3collagen, type VI, alpha 3Skeletal Muscle+1.690.000
33COL4A2collagen, type IV, alpha 2Skeletal Muscle+1.680.000
34SPP1secreted phosphoprotein 1Skeletal Muscle+1.670.000
35TTNtitinSkeletal Muscle-1.630.000
36NESnestinSkeletal Muscle+1.570.000
37S100A6S100 calcium binding protein A6Skeletal Muscle+1.570.000
38COL4A1collagen, type IV, alpha 1Skeletal Muscle+1.540.000
39TNCtenascin CSkeletal Muscle+1.520.000
40CCDC80coiled-coil domain containing 80Skeletal Muscle+1.520.000
41MLLT11myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11Skeletal Muscle+1.500.000
42HLA-DRAmajor histocompatibility complex, class II, DR alphaSkeletal Muscle+1.500.000
43NPY6Rneuropeptide Y receptor Y6 (pseudogene)Skeletal Muscle+1.480.000
44HLA-DPA1major histocompatibility complex, class II, DP alpha 1Skeletal Muscle+1.480.000
45S100A10S100 calcium binding protein A10Skeletal Muscle+1.480.000
46COL5A2collagen, type V, alpha 2Skeletal Muscle+1.470.000
47VCANversicanSkeletal Muscle+1.470.000
48SSPNsarcospanSkeletal Muscle-1.460.000
49IGF2insulin-like growth factor 2 (somatomedin A)Skeletal Muscle+1.440.000
50DPTdermatopontinSkeletal Muscle+1.440.000
51CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)Skeletal Muscle+1.430.000
52MAP4microtubule-associated protein 4Skeletal Muscle-1.430.000
53COL5A1collagen, type V, alpha 1Skeletal Muscle+1.420.000
54TYROBPTYRO protein tyrosine kinase binding proteinSkeletal Muscle+1.420.000
55IFI16interferon, gamma-inducible protein 16Skeletal Muscle+1.420.000
56SPARCsecreted protein, acidic, cysteine-rich (osteonectin)Skeletal Muscle+1.410.000
57SRRM2serine/arginine repetitive matrix 2Skeletal Muscle-1.410.000
58ANGPTL2angiopoietin-like 2Skeletal Muscle+1.410.000
59GJA1gap junction protein, alpha 1, 43kDaSkeletal Muscle+1.400.000
60CILPcartilage intermediate layer protein, nucleotide pyrophosphohydrolaseSkeletal Muscle+1.400.000
61EMP3epithelial membrane protein 3Skeletal Muscle+1.400.000
62MARCKSmyristoylated alanine-rich protein kinase C substrateSkeletal Muscle+1.390.000
63EFEMP1EGF containing fibulin-like extracellular matrix protein 1Skeletal Muscle+1.380.000
64TAGLNtransgelinSkeletal Muscle+1.380.000
65A2Malpha-2-macroglobulinSkeletal Muscle+1.350.000
66PLTPphospholipid transfer proteinSkeletal Muscle+1.340.000
67PTGFRNprostaglandin F2 receptor inhibitorSkeletal Muscle+1.340.000
68FN1fibronectin 1Skeletal Muscle+1.330.000
69C1QCcomplement component 1, q subcomponent, C chainSkeletal Muscle+1.330.000
70CD14CD14 moleculeSkeletal Muscle+1.330.000
71SRPXsushi-repeat containing protein, X-linkedSkeletal Muscle+1.330.000
72TMSB10thymosin beta 10Skeletal Muscle+1.320.000
73LUC7L3LUC7-like 3 (S. cerevisiae)Skeletal Muscle-1.310.000
74TGFBItransforming growth factor, beta-induced, 68kDaSkeletal Muscle+1.310.000
75NXPE3neurexophilin and PC-esterase domain family, member 3Skeletal Muscle-1.300.000
76ICMTisoprenylcysteine carboxyl methyltransferaseSkeletal Muscle+1.290.000
77IGFBP4insulin-like growth factor binding protein 4Skeletal Muscle+1.280.000
78MLECmalectinSkeletal Muscle-1.280.000
79ATP9AATPase, class II, type 9ASkeletal Muscle+1.280.000
80FBN1fibrillin 1Skeletal Muscle+1.280.000
81GPAMglycerol-3-phosphate acyltransferase, mitochondrialSkeletal Muscle-1.270.000
82SONSON DNA binding proteinSkeletal Muscle-1.270.000
83ASH1Lash1 (absent, small, or homeotic)-like (Drosophila)Skeletal Muscle-1.260.000
84COL6A1collagen, type VI, alpha 1Skeletal Muscle+1.260.000
85AXLAXL receptor tyrosine kinaseSkeletal Muscle+1.260.000
86MESTmesoderm specific transcriptSkeletal Muscle+1.250.000
87EIF5Beukaryotic translation initiation factor 5BSkeletal Muscle-1.250.000
88OLFML2Bolfactomedin-like 2BSkeletal Muscle+1.240.000
89SLC25A36solute carrier family 25 (pyrimidine nucleotide carrier ), member 36Skeletal Muscle-1.230.000
90FNDC1fibronectin type III domain containing 1Skeletal Muscle+1.230.000
91UBXN4UBX domain protein 4Skeletal Muscle-1.230.000
92ANXA2annexin A2Skeletal Muscle+1.220.000
93ASB8ankyrin repeat and SOCS box containing 8Skeletal Muscle-1.220.000
94COL15A1collagen, type XV, alpha 1Skeletal Muscle+1.220.000
95HLA-DRB1major histocompatibility complex, class II, DR beta 1Skeletal Muscle+1.220.000
96MGPmatrix Gla proteinSkeletal Muscle+1.210.000
97C1Rcomplement component 1, r subcomponentSkeletal Muscle+1.210.000
98IGFBP5insulin-like growth factor binding protein 5Skeletal Muscle-1.210.000
99ADIRFadipogenesis regulatory factorSkeletal Muscle+1.210.000
100DPYSL2dihydropyrimidinase-like 2Skeletal Muscle+1.200.000
101FSTL1follistatin-like 1Skeletal Muscle+1.200.000
102DDNdendrinSkeletal Muscle+1.200.000
103EZRezrinSkeletal Muscle+1.200.000
104MSNmoesinSkeletal Muscle+1.200.000
105IL17Dinterleukin 17DSkeletal Muscle-1.200.000
106F13A1coagulation factor XIII, A1 polypeptideSkeletal Muscle+1.190.000
107SNX7sorting nexin 7Skeletal Muscle+1.190.000
108LAPTM5lysosomal protein transmembrane 5Skeletal Muscle+1.190.000
109LGALS3BPlectin, galactoside-binding, soluble, 3 binding proteinSkeletal Muscle+1.190.000
110MIR1245AmicroRNA 1245aSkeletal Muscle+1.190.000
111MYBPHmyosin binding protein HSkeletal Muscle+1.180.000
112SH3BGRL3SH3 domain binding glutamate-rich protein like 3Skeletal Muscle+1.180.000
113GPSM2G-protein signaling modulator 2Skeletal Muscle+1.170.000
114ITGB6integrin, beta 6Skeletal Muscle-1.170.000
115ARHGAP36Rho GTPase activating protein 36Skeletal Muscle+1.170.000
116PTGDSprostaglandin D2 synthase 21kDa (brain)Skeletal Muscle+1.170.000
117WWTR1WW domain containing transcription regulator 1Skeletal Muscle+1.170.000
118THY1Thy-1 cell surface antigenSkeletal Muscle+1.160.000
119CD74CD74 molecule, major histocompatibility complex, class II invariant chainSkeletal Muscle+1.160.000
120PNISRPNN-interacting serine/arginine-rich proteinSkeletal Muscle-1.160.000
121UCP2uncoupling protein 2 (mitochondrial, proton carrier)Skeletal Muscle+1.150.000
122ART3ADP-ribosyltransferase 3Skeletal Muscle-1.150.000
123CAP1CAP, adenylate cyclase-associated protein 1 (yeast)Skeletal Muscle+1.150.000
124MYL9myosin, light chain 9, regulatorySkeletal Muscle+1.150.000
125CTGFconnective tissue growth factorSkeletal Muscle+1.140.000
126PPIGpeptidylprolyl isomerase G (cyclophilin G)Skeletal Muscle-1.140.000
127NID1nidogen 1Skeletal Muscle+1.140.000
128LAMP1lysosomal-associated membrane protein 1Skeletal Muscle+1.130.000
129CALRcalreticulinSkeletal Muscle+1.130.000
130DAB2Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)Skeletal Muscle+1.130.000
131COTL1coactosin-like F-actin binding protein 1Skeletal Muscle+1.120.000
132HLA-Emajor histocompatibility complex, class I, ESkeletal Muscle+1.120.000
133LAMA4laminin, alpha 4Skeletal Muscle+1.120.000
134MYADMmyeloid-associated differentiation markerSkeletal Muscle+1.120.000
135IGFBP7insulin-like growth factor binding protein 7Skeletal Muscle+1.120.000
136ZFP36L2ZFP36 ring finger protein-like 2Skeletal Muscle+1.110.000
137SMOC2SPARC related modular calcium binding 2Skeletal Muscle+1.110.000
138C1Scomplement component 1, s subcomponentSkeletal Muscle+1.110.000
139DYNLL1dynein, light chain, LC8-type 1Skeletal Muscle+1.110.000
140CD163CD163 moleculeSkeletal Muscle+1.110.000
141LOXL2lysyl oxidase-like 2Skeletal Muscle+1.100.000
142TIMP2TIMP metallopeptidase inhibitor 2Skeletal Muscle+1.100.000
143SPIN1spindlin 1Skeletal Muscle+1.100.000
144SLC47A1solute carrier family 47 (multidrug and toxin extrusion), member 1Skeletal Muscle-1.100.000
145CD9CD9 moleculeSkeletal Muscle+1.100.000
146WISP2WNT1 inducible signaling pathway protein 2Skeletal Muscle+1.100.000
147CSF1Rcolony stimulating factor 1 receptorSkeletal Muscle+1.090.000
148SAT1spermidine/spermine N1-acetyltransferase 1Skeletal Muscle+1.090.000
149LPIN1lipin 1Skeletal Muscle-1.090.000
150RPL3ribosomal protein L3Skeletal Muscle+1.090.000
151ENO1enolase 1, (alpha)Skeletal Muscle+1.080.000
152NEAT1nuclear paraspeckle assembly transcript 1 (non-protein coding)Skeletal Muscle-1.070.000
153PERPPERP, TP53 apoptosis effectorSkeletal Muscle+1.070.000
154VIMvimentinSkeletal Muscle+1.070.000
155MPEG1macrophage expressed 1Skeletal Muscle+1.070.000
156SERPINH1serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)Skeletal Muscle+1.070.000
157CES2carboxylesterase 2Skeletal Muscle+1.060.000
158IAH1isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)Skeletal Muscle+1.060.000
159SH3BP5SH3-domain binding protein 5 (BTK-associated)Skeletal Muscle+1.060.000
160PLNphospholambanSkeletal Muscle-1.060.000
161C1QAcomplement component 1, q subcomponent, A chainSkeletal Muscle+1.050.000
162MRC1mannose receptor, C type 1Skeletal Muscle+1.050.000
163RNASE1ribonuclease, RNase A family, 1 (pancreatic)Skeletal Muscle+1.050.000
164C3complement component 3Skeletal Muscle+1.050.000
165ANXA1annexin A1Skeletal Muscle+1.040.000
166THRBthyroid hormone receptor, betaSkeletal Muscle-1.040.000
167CTHRC1collagen triple helix repeat containing 1Skeletal Muscle+1.040.000
168MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)Skeletal Muscle+1.040.000
169CTNNA3catenin (cadherin-associated protein), alpha 3Skeletal Muscle-1.040.000
170PDLIM5PDZ and LIM domain 5Skeletal Muscle-1.040.000
171PPP1R16Aprotein phosphatase 1, regulatory subunit 16ASkeletal Muscle-1.040.000
172ASXL2additional sex combs like 2 (Drosophila)Skeletal Muscle+1.040.000
173GPNMBglycoprotein (transmembrane) nmbSkeletal Muscle+1.030.000
174TNFRSF21tumor necrosis factor receptor superfamily, member 21Skeletal Muscle+1.030.000
175PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1Skeletal Muscle-1.030.000
176HNRNPU-AS1HNRNPU antisense RNA 1Skeletal Muscle-1.020.000
177PFN1profilin 1Skeletal Muscle+1.020.000
178RAB31RAB31, member RAS oncogene familySkeletal Muscle+1.020.000
179TTC3tetratricopeptide repeat domain 3Skeletal Muscle-1.020.000
180USP16ubiquitin specific peptidase 16Skeletal Muscle-1.020.000
181CFHcomplement factor HSkeletal Muscle+1.010.000
182LGMNlegumainSkeletal Muscle+1.010.000
183GOLGA4golgin A4Skeletal Muscle-1.010.000
184ACTN1actinin, alpha 1Skeletal Muscle+1.010.000
185ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDaSkeletal Muscle+1.010.000
186HECTD1HECT domain containing E3 ubiquitin protein ligase 1Skeletal Muscle-1.000.000
187TGFBR2transforming growth factor, beta receptor II (70/80kDa)Skeletal Muscle+1.000.000
188MYOFmyoferlinSkeletal Muscle+1.000.000

Expression patterns in normal tissues for genes affiliated with Becker Muscular Dystrophy

Search GEO for disease gene expression data for Becker Muscular Dystrophy.

Pathways for genes affiliated with Becker Muscular Dystrophy

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Compounds for genes affiliated with Becker Muscular Dystrophy

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Sources:
44Novoseek, 25HMDB, 29IUPHAR, 12DrugBank, 50PharmGKB
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Compounds related to Becker Muscular Dystrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1succinate449.7DMD, CHKB
2ornithine44 2510.6CHKB, DMD
3prednisolone44 29 1211.6CHKB, DMD
4urea44 25 1211.6DMD, CHKB
5agarose449.5CHKB, DMD
6polyacrylamide449.5CHKB, DMD
7glycerol44 25 1211.4CHKB, DMD
8tacrolimus44 50 1211.2CHKB, DMD
9creatinine448.3CHKB, FKRP, MYF6, DMD

GO Terms for genes affiliated with Becker Muscular Dystrophy

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Cellular components related to Becker Muscular Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:0423839.4FKRP, DMD
2dystrophin-associated glycoprotein complexGO:0160109.1FKRP, DMD

Products for genes affiliated with Becker Muscular Dystrophy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Becker Muscular Dystrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet