MCID: BCK001
MIFTS: 62

Becker Muscular Dystrophy malady

Genetic diseases, Rare diseases, Neuronal diseases, Muscle diseases categories

Summaries for Becker Muscular Dystrophy

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OMIM:47 The muscular dystrophy that carries the Becker eponym is similar to Duchenne muscular dystrophy in the distribution of... (300376) more...

MalaCards based summary: Becker Muscular Dystrophy, also known as benign pseudohypertrophic muscular dystrophy, is related to muscular dystrophy and duchenne muscular dystrophy, and has symptoms including hyporeflexia, muscle weakness and x-linked recessive inheritance. An important gene associated with Becker Muscular Dystrophy is DMD (dystrophin). The compounds succinate and ornithine have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, heart and testes, and related mouse phenotypes are vision/eye and muscle.

NIH Rare Diseases:43 Becker muscular dystrophy (bmd) is an inherited condition that primarily affects males and causes progressive weakness and wasting of the skeletal and cardiac (heart) muscles. the age of onset and rate of progression can vary among affected people. muscle weakness usually becomes apparent between the ages of 5 and 15. in some cases, heart involvement (cardiomyopathy) is the first sign. bmd is caused by a mutation in the dmd gene and is inherited in an x-linked recessive manner. bmd is very similar to duchenne muscular dystrophy, except that symptoms begin later and progress at a slower rate. there is no cure for this condition, and treatment aims to relieve symptoms to help quality of life. people with bmd may survive into their 40s or beyond. last updated: 3/5/2014

Aliases & Classifications for Becker Muscular Dystrophy

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Sources:
47OMIM, 32LifeMap Discovery®, 10Disease Ontology, 11diseasecard, 43NIH Rare Diseases, 22GeneTests, 12DISEASES, 45Novoseek, 49Orphanet, 24GTR, 62UMLS, 57SNOMED-CT, 29ICD9CM, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Becker Muscular Dystrophy, Aliases & Descriptions:

Name: Becker Muscular Dystrophy 47 32 10 11 43 12 49 62
Benign Pseudohypertrophic Muscular Dystrophy 10 43 62
Muscular Dystrophy, Becker Type 47 43
Becker's Muscular Dystrophy 43 22
Benign Congenital Myopathy 10 62
 
Muscular Dystrophy Becker 45 24
Becker Dystrophinopathy 43 49
Bmd 43 49
Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Muscle diseases


Characteristics (Orphanet epidemiological data):

49
becker muscular dystrophy:
Inheritance: X-linked recessive; Prevalence: 1-9/100000 (Europe); Age of onset: Childhood; Age of death: any age


External Ids:

OMIM47 300376
Disease Ontology10 DOID:9883
ICD9CM29 359.0
Orphanet49 98895
MESH via Orphanet36 C537666
ICD10 via Orphanet28 G71.0
UMLS via Orphanet63 C0917713

Related Diseases for Becker Muscular Dystrophy

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Diseases related to Becker Muscular Dystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1muscular dystrophy32.3CHKB, FKRP, DMD
2duchenne muscular dystrophy31.3CHKB, DMD
3myopathy31.0CHKB, FKRP, DMD
4dilated cardiomyopathy30.9DMD, FKRP, CHKB
5limb-girdle muscular dystrophy30.7FKRP, DMD
6myotonic dystrophy30.6DMD, CHKB
7neuromuscular disease30.4DMD, CHKB
8myositis30.4DMD, CHKB
9neuropathy30.4DMD, FKRP
10mental retardation30.4FKRP, DMD
11spinal muscular atrophy10.5
12muscular atrophy10.5
13osteoporosis10.5
14muscle hypertrophy10.5
15malignant hyperthermia10.5
16klinefelter's syndrome10.4
17ischemia10.4
18muscular dystrophy, duchenne and becker types10.4
19myotonia10.4
20osteoporotic fracture10.3
21schizophrenia10.2
22bethlem myopathy10.2
23pulmonary function10.2
24wolff-parkinson-white syndrome10.2
25angelman syndrome10.2
26glycerol kinase deficiency10.2
27celiac disease10.2
28arthritis10.2
29liver disease10.2
30fatty liver disease10.2
31neuronitis10.2
32cerebritis10.2
33atrioventricular block10.2
34sleep apnea10.2
35mitochondrial disorders10.2
36growth hormone deficiency10.2
37left ventricular noncompaction10.2
38nondystrophic myotonia10.2
39sarcoglycanopathies10.2
40anorexia nervosa10.2
41obesity10.1
42bone fracture10.1
43best vitelliform macular dystrophy10.1
44gas gangrene10.0DMD
45myopathy, centronuclear10.0DMD
46distal muscular dystrophy10.0DMD, CHKB
47myopathy congenital10.0DMD, CHKB
48turner syndrome10.0DMD, SHOX
49muscular dystrophy, limb-girdle, type 2g10.0FKRP, DMD
50muscle eye brain disease10.0DMD, FKRP

Graphical network of the top 20 diseases related to Becker Muscular Dystrophy:



Diseases related to becker muscular dystrophy

Symptoms for Becker Muscular Dystrophy

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Symptoms by clinical synopsis from OMIM:

300376

Clinical features from OMIM:

300376

HPO human phenotypes related to Becker Muscular Dystrophy:

(show all 9)
id Description Frequency HPO Source Accession
1 hyporeflexia HP:0001265
2 muscle weakness HP:0001324
3 x-linked recessive inheritance HP:0001419
4 cardiomyopathy HP:0001638
5 elevated serum creatine phosphokinase HP:0003236
6 myalgia HP:0003326
7 adult onset HP:0003581
8 calf muscle pseudohypertrophy HP:0003707
9 arrhythmia HP:0011675

Drugs & Therapeutics for Becker Muscular Dystrophy

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Drug clinical trials:

Search ClinicalTrials for Becker Muscular Dystrophy

Search NIH Clinical Center for Becker Muscular Dystrophy

Genetic Tests for Becker Muscular Dystrophy

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Genetic tests related to Becker Muscular Dystrophy:

id Genetic test Affiliating Genes
1 Becker Muscular Dystrophy22 24

Anatomical Context for Becker Muscular Dystrophy

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MalaCards organs/tissues related to Becker Muscular Dystrophy:

33
Skeletal muscle, Heart, Testes, Myeloid, Brain, Lung, Thyroid, Colon, Liver

Animal Models for Becker Muscular Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Becker Muscular Dystrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.6FKRP, MYF6, DMD
2MP:00053698.1CHKB, FKRP, MYF6, DMD
3MP:00053908.0DMD, MYF6, FKRP, CHKB
4MP:00053767.8CHKB, FKRP, MYF6, DMD

Publications for Becker Muscular Dystrophy

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Articles related to Becker Muscular Dystrophy:

(show top 50)    (show all 471)
idTitleAuthorsYear
1
Early-progressive dilated cardiomyopathy in a family with Becker muscular dystrophy related to a novel frameshift mutation in the dystrophin gene exon 27. (25537791)
2015
2
Diagnosis of Becker muscular dystrophy: Results of re-analysis of DNA samples. (25900853)
2015
3
Psychological and practical difficulties among parents and healthy siblings of children with Duchenne vs. Becker muscular dystrophy: an Italian comparative study. (25873782)
2014
4
Genetic testing for Duchenne/Becker muscular dystrophy in Johannesburg, South Africa. (24300647)
2013
5
Genetic analysis of dystrophin gene for affected male and female carriers with Duchenne/Becker muscular dystrophy in Korea. (22379338)
2012
6
Novel mutation in spectrin-like repeat 1 of dystrophin central domain causes protein misfolding and mild Becker muscular dystrophy. (22453924)
2012
7
Prenatal diagnosis of Duchenne/Becker muscular dystrophy by short tandem repeat segregation analysis in Argentine families. (21305566)
2011
8
Becker muscular dystrophy patients with deletions around exon 51; a promising outlook for exon skipping therapy in Duchenne patients. (20153965)
2010
9
The 6-minute walk test in Duchenne/Becker muscular dystrophy: longitudinal observations. (21038378)
2010
10
Commentary on 'Mutation spectrum of the dystrophin gene in 442 Duchenne/Becker muscular dystrophy cases from one Japanese referral center'. (20555341)
2010
11
Cardiac involvement in Becker muscular dystrophy. (18841259)
2008
12
Life expectancy and death from cardiomyopathy amongst carriers of Duchenne and Becker muscular dystrophy in Scotland. (17932095)
2008
13
Patterns of dystrophin gene deletion in Egyptian Duchenne/Becker muscular dystrophy patients. (18646563)
2007
14
Late gadolinium enhanced cardiovascular magnetic resonance in Becker muscular dystrophy. (15310728)
2004
15
Valley sign in Becker muscular dystrophy and outliers of Duchenne and Becker muscular dystrophy. (15269471)
2004
16
Electroretinographic findings in Duchenne/Becker muscular dystrophy and correlation with genotype. (12324874)
2002
17
Carrier detection of Duchenne/Becker muscular dystrophy by analysis of STRs loci linked to the gene of dystrophin in Venezuelan families]. (12520997)
2002
18
Carrier detection and prenatal diagnosis in Duchenne/Becker muscular dystrophy. (11418728)
2001
19
Absence of brain Dp140 isoform and cognitive impairment in Becker muscular dystrophy. (10093987)
1999
20
Statistically significant differences in the number of CD24 positive muscle fibers and satellite cells between sarcoglycanopathy and age-matched Becker muscular dystrophy patients. (10397078)
1999
21
Genetic polymorphism in muscle biopsies of Duchenne and Becker muscular dystrophy patients. (10514583)
1999
22
Deletion patterns in Argentine patients with Duchenne and Becker muscular dystrophy. (9664586)
1998
23
Pilot study of myoblast transfer in the treatment of Becker muscular dystrophy. (9710042)
1998
24
Epilepsy in Duchenne and Becker muscular dystrophies. (10728205)
1997
25
Cardiac function, metabolism and perfusion in Duchenne and Becker muscular dystrophy. (8887952)
1996
26
PCR techniques for deletion, linkage, and mutation analysis in duchenne/becker muscular dystrophy. (21374510)
1996
27
Accurate diagnosis of carriers of deletions and duplications in Duchenne/Becker muscular dystrophy by fluorescent dosage analysis. (8818939)
1996
28
An unusual association: celiac disease and Becker muscular dystrophy. (8678019)
1996
29
In utero fetal muscle biopsy alters diagnosis and carrier risks in Duchenne and Becker muscular dystrophy. (7794517)
1995
30
Variability in clinical, genetic and protein abnormalities in manifesting carriers of Duchenne and Becker muscular dystrophy. (8329890)
1993
31
Duchenne/Becker muscular dystrophy carrier detection using quantitative PCR and fluorescence-based strategies. (7510932)
1993
32
Effects of electrical stimulation on muscles of children with Duchenne and Becker muscular dystrophy. (8232775)
1993
33
Verification of carrier status for Becker muscular dystrophy from analysis of a blighted ovum. (8284293)
1993
34
Carrier detection of Duchenne/Becker muscular dystrophy: computer-assisted direct quantitation of gene amplification products. (1621929)
1992
35
Delayed expression of dystrophin on regenerating muscle from two siblings with Becker muscular dystrophy. (1506856)
1992
36
Dystrophin in frameshift deletion patients with Becker muscular dystrophy. (1496988)
1992
37
Carrier detection of Duchenne and Becker muscular dystrophy using muscle dystrophin immunohistochemistry. (1309152)
1992
38
Detection of Duchenne and Becker muscular dystrophy carriers by quantitative multiplex polymerase chain reaction analysis. (1513470)
1992
39
Dystrophin as a diagnostic marker in Duchenne and Becker muscular dystrophy. Correlation of immunofluorescence and western blot. (1944822)
1991
40
Analysis of Scottish Duchenne and Becker muscular dystrophy families with dystrophin cDNA probes. (2191136)
1990
41
Quadriceps myopathy: forme fruste of Becker muscular dystrophy. (2260849)
1990
42
An unusual variant of Becker muscular dystrophy. (2193611)
1990
43
Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies. (2261642)
1990
44
Dystrophin abnormalities in Duchenne/Becker muscular dystrophy. (2696500)
1989
45
Detection of Duchenne/Becker muscular dystrophy carriers by densitometric scanning. (2731350)
1989
46
The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion. (2491009)
1989
47
Direct method for prenatal diagnosis and carrier detection in Duchenne/Becker muscular dystrophy using the entire dystrophin cDNA. (2897793)
1988
48
The application of linkage analysis to genetic counselling in families with Duchenne or Becker muscular dystrophy. (3572997)
1987
49
Genetic linkage relationships of seven DNA probes with Duchenne and Becker muscular dystrophy. (2993158)
1985
50
Definitive localization of Becker muscular dystrophy in Xp by linkage to a cluster of DNA polymorphisms (DXS43 and DXS9). (2993155)
1985

Variations for Becker Muscular Dystrophy

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UniProtKB/Swiss-Prot genetic disease variations for Becker Muscular Dystrophy:

64
id Symbol AA change Variation ID SNP ID
1DMDp.Ala168AspVAR_005149
2DMDp.Tyr231AsnVAR_005150
3DMDp.His2921ArgVAR_005170rs1800279
4DMDp.Ala3421ValVAR_005172
5DMDp.Ala171ProVAR_023539

Clinvar genetic disease variations for Becker Muscular Dystrophy:

7 (show all 14)
id Gene Variation Type Significance SNP ID Assembly Location
1DMDDMD, IVS19, A-C, +3single nucleotide variantPathogenic
2DMDDMD, IVS57, G-C, -1single nucleotide variantPathogenic
3DMDNM_004006.2(DMD): c.503C> A (p.Ala168Asp)single nucleotide variantPathogenicrs128626236GRCh37Chr X, 32834612: 32834612
4DMDDMD, IVS2, G-T, -1single nucleotide variantPathogenic
5DMDNM_004006.2(DMD): c.691T> A (p.Tyr231Asn)single nucleotide variantPathogenicrs128626237GRCh37Chr X, 32717369: 32717369
6DMDBMD, IVS13, G-T, -1single nucleotide variantPathogenic
7DMDNM_004006.2(DMD): c.8762A> G (p.His2921Arg)single nucleotide variantPathogenicrs1800279GRCh37Chr X, 31496398: 31496398
8DMDNM_004006.2(DMD): c.10262C> T (p.Ala3421Val)single nucleotide variantPathogenicrs104894791GRCh37Chr X, 31196049: 31196049
9DMDDMD, 1-BP DEL, 10683CdeletionPathogenic
10DMDNM_004006.2(DMD): c.3631G> T (p.Glu1211Ter)single nucleotide variantPathogenicrs267606771GRCh37Chr X, 32466728: 32466728
11DMDNM_004006.2(DMD): c.3940C> T (p.Arg1314Ter)single nucleotide variantPathogenicrs5030730GRCh37Chr X, 32456489: 32456489
12DMDNM_004006.2(DMD): c.9225-285A> Gsingle nucleotide variantPathogenicGRCh37Chr X, 31279418: 31279418
13DMDDMD, IVS25, A-G, +2036single nucleotide variantPathogenic
14DMDNM_004006.2(DMD): c.9G> A (p.Trp3Ter)single nucleotide variantPathogenicrs398122853GRCh37Chr X, 33229421: 33229421

Expression for genes affiliated with Becker Muscular Dystrophy

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LifeMap Discovery
Genes differentially expressed in tissues of Becker Muscular Dystrophy patients vs. healthy controls: 32 (show all 188)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MYH8myosin, heavy chain 8, skeletal muscle, perinatalSkeletal Muscle+3.890.000
2PRUNE2prune homolog 2 (Drosophila)Skeletal Muscle+3.830.001
3CHRNA1cholinergic receptor, nicotinic, alpha 1 (muscle)Skeletal Muscle+3.820.000
4COL19A1collagen, type XIX, alpha 1Skeletal Muscle+3.770.000
5LRRK2leucine-rich repeat kinase 2Skeletal Muscle+3.670.001
6FSTfollistatinSkeletal Muscle+3.470.001
7CERKLceramide kinase-likeSkeletal Muscle+3.460.000
8RMDN2regulator of microtubule dynamics 2Skeletal Muscle+3.440.005
9MUSKmuscle, skeletal, receptor tyrosine kinaseSkeletal Muscle+3.220.001
10SESN3sestrin 3Skeletal Muscle+3.190.007
11CPNE8copine VIIISkeletal Muscle+3.060.001
12LOC100506082uncharacterized LOC100506082Blood-3.030.006
13TNXBtenascin XBBlood-3.020.012
14IL17Ainterleukin 17ABlood-3.010.005
15CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 5Blood-3.010.040
16IQUBIQ motif and ubiquitin domain containingBlood-3.010.026
17COL4A5collagen, type IV, alpha 5Blood-3.010.002
18CSPG4chondroitin sulfate proteoglycan 4Blood-3.000.024
19GADD45Agrowth arrest and DNA-damage-inducible, alphaSkeletal Muscle+3.000.009
20CHRNGcholinergic receptor, nicotinic, gamma (muscle)Skeletal Muscle+2.980.001
21ALDOBaldolase B, fructose-bisphosphateBlood-2.970.047
22MTMR1myotubularin related protein 1Blood-2.960.001
23EFCAB13EF-hand calcium binding domain 13Blood-2.960.034
24CASD1CAS1 domain containing 1Blood-2.950.019
25IQCA1IQ motif containing with AAA domain 1Blood-2.940.045
26SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Blood-2.930.002
27PDE4Aphosphodiesterase 4A, cAMP-specificBlood-2.900.003
28FLJ90680FLJ90680 proteinBlood-2.900.001
29ACTC1actin, alpha, cardiac muscle 1Skeletal Muscle+2.900.002
30SULT1E1sulfotransferase family 1E, estrogen-preferring, member 1Blood-2.890.012
31SPANXA2-OT1SPANXA2 overlapping transcript 1 (non-protein coding)Blood-2.880.011
32PPP1R14Bprotein phosphatase 1, regulatory (inhibitor) subunit 14BBlood-2.880.004
33ARHGAP28Rho GTPase activating protein 28Skeletal Muscle+2.880.004
34GSTA3glutathione S-transferase alpha 3Blood-2.880.013
35CYMPchymosin pseudogeneBlood-2.870.001
36LOC100287808uncharacterized LOC100287808Blood-2.870.008
37SLC30A7solute carrier family 30 (zinc transporter), member 7Blood-2.850.008
38DLEU7deleted in lymphocytic leukemia, 7Blood-2.850.004
39LAYNlayilinBlood-2.830.007
40FAM64Afamily with sequence similarity 64, member ABlood-2.830.026
41TPD52L1tumor protein D52-like 1Blood-2.810.003
42LOC283788FSHD region gene 1 pseudogeneBlood-2.800.021
43CXADRcoxsackie virus and adenovirus receptorBlood-2.790.035
44CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1Blood-2.790.001
45MYO7Bmyosin VIIBBlood-2.780.022
46C1orf220chromosome 1 open reading frame 220Blood-2.780.038
47ZNF233zinc finger protein 233Blood-2.770.005
48SPON1spondin 1, extracellular matrix proteinBlood-2.770.011
49KRT19P2keratin 19 pseudogene 2Blood-2.760.038
50PMEPA1prostate transmembrane protein, androgen induced 1Blood-2.760.047
51ZNF81zinc finger protein 81Blood-2.730.009
52APOA2apolipoprotein A-IIBlood-2.730.042
53GPR98G protein-coupled receptor 98Skeletal Muscle+2.720.000
54TMEM217transmembrane protein 217Blood-2.720.005
55ZNF519zinc finger protein 519Blood-2.720.014
56MAN1A2mannosidase, alpha, class 1A, member 2Blood-2.710.032
57PCSK2proprotein convertase subtilisin/kexin type 2Blood-2.710.028
58NELL1NEL-like 1 (chicken)Blood-2.710.037
59TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)Blood-2.700.009
60TONSLtonsoku-like, DNA repair proteinBlood-2.700.012
61SRRM5serine/arginine repetitive matrix 5Blood-2.690.009
62PWRN1Prader-Willi region non-protein coding RNA 1Blood-2.690.014
63CLLU1chronic lymphocytic leukemia up-regulated 1Skeletal Muscle+2.680.006
64INADLInaD-like (Drosophila)Blood-2.640.038
65ANXA1annexin A1Skeletal Muscle+2.620.040
66PREPLprolyl endopeptidase-likeSkeletal Muscle+2.600.001
67LRRTM1leucine rich repeat transmembrane neuronal 1Blood-2.590.030
68ZIC5Zic family member 5Blood-2.590.012
69FAM161Afamily with sequence similarity 161, member ABlood-2.570.041
70CRNNcornulinBlood-2.570.012
71WNT5Awingless-type MMTV integration site family, member 5ABlood-2.570.022
72PGM5phosphoglucomutase 5Blood-2.550.001
73TNP2transition protein 2 (during histone to protamine replacement)Blood-2.550.046
74GXYLT2glucoside xylosyltransferase 2Skeletal Muscle+2.540.045
75TMPRSS5transmembrane protease, serine 5Blood-2.540.001
76CCKARcholecystokinin A receptorBlood-2.530.022
77CRISP1cysteine-rich secretory protein 1Blood-2.530.012
78VWA3Avon Willebrand factor A domain containing 3ABlood-2.530.039
79GUSBP4glucuronidase, beta pseudogene 4Blood-2.520.040
80ACVR1Bactivin A receptor, type IBBlood-2.520.022
81CFHcomplement factor HSkeletal Muscle+2.510.016
82LINC00521long intergenic non-protein coding RNA 521Blood-2.510.039
83AMFRautocrine motility factor receptor, E3 ubiquitin protein ligaseBlood-2.510.025
84CETN1centrin, EF-hand protein, 1Blood-2.500.018
85CCNYcyclin YBlood-2.500.025
86NDST4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4Blood-2.490.030
87EFCAB6EF-hand calcium binding domain 6Blood-2.480.034
88CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)Blood-2.470.018
89COL10A1collagen, type X, alpha 1Blood-2.470.018
90NKAPP1NFKB activating protein pseudogene 1Blood-2.470.012
91SLC44A1solute carrier family 44 (choline transporter), member 1Blood-2.470.038
92MAGEA4melanoma antigen family A, 4Blood-2.470.003
93MAP1Bmicrotubule-associated protein 1BBlood-2.470.005
94CNTN4contactin 4Blood-2.460.047
95RNU5D-1RNA, U5D small nuclear 1Skeletal Muscle+2.460.003
96LACE1lactation elevated 1Blood-2.460.027
97SLC2A12solute carrier family 2 (facilitated glucose transporter), member 12Blood-2.450.048
98M1APmeiosis 1 associated proteinBlood-2.440.012
99ARR3arrestin 3, retinal (X-arrestin)Blood-2.440.013
100TMC6transmembrane channel-like 6Blood-2.440.007
101MUC3Bmucin 3B, cell surface associatedBlood-2.430.019
102CSRP2cysteine and glycine-rich protein 2Blood-2.430.006
103RASEFRAS and EF-hand domain containingBlood-2.420.018
104ZNF264zinc finger protein 264Blood-2.410.030
105TM4SF20transmembrane 4 L six family member 20Blood-2.410.002
106CACNA1Bcalcium channel, voltage-dependent, N type, alpha 1B subunitBlood-2.400.008
107RIPPLY1ripply transcriptional repressor 1Blood-2.400.042
108LOC730101uncharacterized LOC730101Blood-2.390.016
109VSTM4V-set and transmembrane domain containing 4Blood-2.390.043
110SPATA9spermatogenesis associated 9Blood-2.380.038
111PER2period circadian clock 2Blood-2.370.035
112CEP70centrosomal protein 70kDaBlood-2.360.026
113ZNF595zinc finger protein 595Blood-2.360.036
114MEGF10multiple EGF-like-domains 10Skeletal Muscle+2.350.001
115DENND5BDENN/MADD domain containing 5BBlood-2.350.031
116GIPC3GIPC PDZ domain containing family, member 3Blood-2.320.005
117FOXP3forkhead box P3Blood-2.320.026
118SLNsarcolipinBlood-2.320.042
119KIAA1549KIAA1549Blood-2.320.029
120JUNjun proto-oncogeneBlood-2.310.021
121TBC1D16TBC1 domain family, member 16Blood-2.310.015
122C2CD2LC2CD2-likeBlood-2.310.006
123RGSL1regulator of G-protein signaling like 1Blood-2.310.042
124VWA1von Willebrand factor A domain containing 1Blood-2.300.041
125PTGFRprostaglandin F receptor (FP)Skeletal Muscle+2.290.003
126PDE6Bphosphodiesterase 6B, cGMP-specific, rod, betaBlood-2.290.044
127SLC47A2solute carrier family 47 (multidrug and toxin extrusion), member 2Skeletal Muscle+2.290.002
128CROCCP2ciliary rootlet coiled-coil, rootletin pseudogene 2Blood-2.280.043
129NOX1NADPH oxidase 1Blood-2.280.024
130POU3F2POU class 3 homeobox 2Blood-2.270.014
131OSBPL8oxysterol binding protein-like 8Skeletal Muscle+2.260.050
132OPALINoligodendrocytic myelin paranodal and inner loop proteinBlood-2.250.049
133LIPJlipase, family member JSkeletal Muscle+2.250.004
134EPS8L2EPS8-like 2Blood-2.250.021
135EFCAB7EF-hand calcium binding domain 7Skeletal Muscle+2.250.015
136LIMK1LIM domain kinase 1Blood-2.240.031
137ADCY10adenylate cyclase 10 (soluble)Blood-2.240.007
138TXNRD3thioredoxin reductase 3Blood-2.230.044
139PDE4Dphosphodiesterase 4D, cAMP-specificBlood-2.220.047
140ZNF385Dzinc finger protein 385DSkeletal Muscle+2.220.000
141PER4period circadian clock 3 pseudogeneBlood-2.200.018
142ATXN7L1ataxin 7-like 1Blood-2.200.013
143CAPRIN2caprin family member 2Skeletal Muscle+2.200.007
144PLEKHB1pleckstrin homology domain containing, family B (evectins) member 1Blood-2.200.010
145FOXI1forkhead box I1Blood-2.190.028
146REG3Gregenerating islet-derived 3 gammaBlood-2.190.047
147LINC00612long intergenic non-protein coding RNA 612Blood-2.190.040
148CABP2calcium binding protein 2Blood-2.180.030
149ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Blood-2.180.005
150FRZBfrizzled-related proteinSkeletal Muscle+2.170.003
151SERTAD4SERTA domain containing 4Blood-2.170.004
152SPAG17sperm associated antigen 17Skeletal Muscle+2.170.015
153RGS2regulator of G-protein signaling 2, 24kDaSkeletal Muscle+2.170.008
154PPARGC1Bperoxisome proliferator-activated receptor gamma, coactivator 1 betaBlood-2.160.033
155LOC154872putative uncharacterized protein LOC154872Blood-2.160.027
156PHKG1phosphorylase kinase, gamma 1 (muscle)Blood-2.160.043
157ZNF709zinc finger protein 709Blood-2.140.037
158SLC16A6solute carrier family 16, member 6Skeletal Muscle+2.140.003
159RCBTB2regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2Blood-2.140.008
160MAGOHBmago-nashi homolog B (Drosophila)Blood-2.120.049
161PNPLA3patatin-like phospholipase domain containing 3Skeletal Muscle+2.100.031
162C9orf116chromosome 9 open reading frame 116Blood-2.100.036
163CYTIPcytohesin 1 interacting proteinSkeletal Muscle+2.090.002
164MIR133BmicroRNA 133bSkeletal Muscle+2.090.008
165SPATA45spermatogenesis associated 45Blood-2.070.017
166FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)Blood-2.070.041
167IGFBP2insulin-like growth factor binding protein 2, 36kDaBlood-2.070.008
168ITGA11integrin, alpha 11Blood-2.070.015
169MAGI1membrane associated guanylate kinase, WW and PDZ domain containing 1Blood-2.050.031
170CEP152centrosomal protein 152kDaBlood-2.050.005
171LAMA4laminin, alpha 4Blood-2.050.036
172CENPAcentromere protein ABlood-2.040.038
173BTN1A1butyrophilin, subfamily 1, member A1Blood-2.030.008
174P2RX6purinergic receptor P2X, ligand-gated ion channel, 6Blood-2.030.021
175FLRT3fibronectin leucine rich transmembrane protein 3Blood-2.020.029
176ZNF214zinc finger protein 214Blood-2.010.042
177DYNC1H1dynein, cytoplasmic 1, heavy chain 1Blood-1.990.033
178NUB1negative regulator of ubiquitin-like proteins 1Blood-1.980.028
179PIEZO2piezo-type mechanosensitive ion channel component 2Blood-1.980.037
180BDH23-hydroxybutyrate dehydrogenase, type 2Blood-1.970.017
181LZTS3leucine zipper, putative tumor suppressor family member 3Blood-1.950.034
182CSMD2CUB and Sushi multiple domains 2Blood-1.920.044
183FXYD1FXYD domain containing ion transport regulator 1Blood-1.890.016
184CDRT1CMT1A duplicated region transcript 1Blood-1.800.021
185EXOSC2exosome component 2Blood-1.770.034
186HNRNPMheterogeneous nuclear ribonucleoprotein MBlood-1.720.046
187RPL10ribosomal protein L10Blood-1.660.019
188ZNF460zinc finger protein 460Blood-1.650.037


Search GEO for disease gene expression data for Becker Muscular Dystrophy.

Pathways for genes affiliated with Becker Muscular Dystrophy

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Compounds for genes affiliated with Becker Muscular Dystrophy

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Sources:
45Novoseek, 26HMDB, 30IUPHAR, 13DrugBank, 51PharmGKB
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Compounds related to Becker Muscular Dystrophy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1succinate459.7DMD, CHKB
2ornithine45 2610.6CHKB, DMD
3prednisolone45 30 1311.6CHKB, DMD
4urea45 26 1311.6DMD, CHKB
5agarose459.5CHKB, DMD
6polyacrylamide459.5CHKB, DMD
7glycerol45 26 1311.4CHKB, DMD
8tacrolimus45 51 1311.2CHKB, DMD
9creatinine458.3CHKB, FKRP, MYF6, DMD

GO Terms for genes affiliated with Becker Muscular Dystrophy

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Cellular components related to Becker Muscular Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sarcolemmaGO:00423839.4FKRP, DMD
2dystrophin-associated glycoprotein complexGO:00160109.1FKRP, DMD

Products for genes affiliated with Becker Muscular Dystrophy

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  • Antibodies
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Sources for Becker Muscular Dystrophy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet