MCID: BHC003
MIFTS: 61

Behcet Syndrome malady

Categories: Rare diseases, Neuronal diseases, Eye diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Skin diseases

Aliases & Classifications for Behcet Syndrome

About this section
Sources:
11Disease Ontology, 13DISEASES, 25Genetics Home Reference, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 35LifeMap Discovery®, 38MedlinePlus, 39MeSH, 40MESH via Orphanet, 45NCIt, 48NIH Rare Diseases, 49NINDS, 50Novoseek, 52OMIM, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Behcet Syndrome:

Name: Behcet Syndrome 52 11 48 25 39 35 68
Behcet's Disease 35 11 48 49 13
Behcet's Syndrome 11 48 25 38
Behçet Disease 48 25 54
Adamantiades-Behcet Disease 11 25
Triple Symptom Complex 11 25
Behcet Disease 25 50
Behcet Triple Symptom Complex 25
 
Old Silk Route Disease 25
Behçet’s Disease 48
Behçet's Syndrome 48
Behçet's Disease 48
Behet's Syndrome 11
Behçet Syndrome 48
Bd 48

Characteristics:

Orphanet epidemiological data:

54
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000 (Japan),>1/1000 (Turkey); Age of onset: Adolescent,Adult,Childhood; Age of death: adult

Classifications:



External Ids:

OMIM52 109650
Disease Ontology11 DOID:13241
ICD1030 M35.2
ICD9CM32 136.1
MeSH39 D001528
NCIt45 C34416
Orphanet54 ORPHA117
MESH via Orphanet40 D001528
UMLS via Orphanet69 C0004943
ICD10 via Orphanet31 M35.2

Summaries for Behcet Syndrome

About this section
NIH Rare Diseases:48 Behçet disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. In some people, the disease also results in arthritis (swollen, painful, stiff joints), skin problems, and inflammation of the digestive tract, brain, and spinal cord. Although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. The disease is common in Japan, Turkey and Israel, and less common in the United States. The exact cause of Behçet disease is still unknown.  Treatment is symptomatic and supportive. Research is being conducted on the use of interferon-alpha and with agents which inhibit tumor necrosis factor (TNF) for the treatment of Behçet disease. Behçet disease is a lifelong disorder that comes and goes. Spontaneous remission over time is common for individuals with Behçet disease but permanent remission of symptoms has not been reported. Last updated: 11/2/2016

MalaCards based summary: Behcet Syndrome, also known as behcet's disease, is related to dementia - subcortical and bd syndrome, and has symptoms including photophobia, meningitis and arthritis. An important gene associated with Behcet Syndrome is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways are Canonical NF-kappaB pathway and Th2 Differentiation Pathway. The drug thalidomide has been mentioned in the context of this disorder. Affiliated tissues include eye, skin and spinal cord, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm.

Disease Ontology:11 A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

Genetics Home Reference:25 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.

MedlinePlus:38 Behcet's syndrome is a disease that involves vasculitis, which is inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

NINDS:49 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Wikipedia:71 Behçet\'s disease is a rare immune-mediated small-vessel systemic vasculitis that often presents with... more...

Description from OMIM:52 109650

Related Diseases for Behcet Syndrome

About this section

Diseases related to Behcet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1dementia - subcortical32.8FAS, IL10, TNF
2bd syndrome11.9
3juvenile spondyloarthropathy11.1MEFV, NOD2, PSTPIP1
4pulmonary interstitial glycogenosis11.1IL10, NOD2, TLR4
5autosomal recessive secondary polycythemia not associated with vhl gene11.1MEFV, TNFRSF1A
6adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency11.1MEFV, TNFRSF1A
712p12.1 microdeletion syndrome11.1FAS, IL10, TNF
8piepkorn karp hickok syndrome11.1IL10, TNF
9multiple sclerosis 511.0MEFV, TNF, TNFRSF1A
10benign adult familial myoclonic epilepsy11.0FAS, IL10, STAT4
11hernia of ovary and fallopian tube11.0HLA-B, IL10, TNF
12lipodermatosclerosis11.0HLA-B, IL10, TNF
13oropharynx cancer11.0NOD2, PSTPIP1, TNF
14sensorineural hearing loss11.0HLA-B, IL10, TNF
15hemophagocytic lymphohistiocytosis11.0HLA-B, IL10, TNF
16uterine corpus endometrial stromal sarcoma11.0NOD2, PSTPIP1, TNF
17allergic hypersensitivity disease11.0HLA-B, IL10, TNF
18meier-gorlin syndrome 311.0MEFV, NOD2, TNF
19senile cataract11.0IL10, MEFV, TNF
20antigen-peptide-transporter 2 deficiency11.0HLA-B, TLR4, TNF
21pyloric stenosis, infantile hypertrophic, 211.0MEFV, PSTPIP1, TNF, TNFRSF1A
22benign renovascular hypertension11.0HLA-B, IL10, NOD2, TNF
23psoriasis susceptibility 111.0HLA-B, NOD2, TNF, TNFRSF1A
24neurotic excoriation11.0IL10, LTA, TNF
25gastric dilatation11.0HLA-B, IL10, TNF
26panuveitis11.0IL10, LTA, TNF
27hypospadias11.0IL10, IL12RB2, TNF
28hodgkin's lymphoma, mixed cellularity11.0HLA-B, IL10, MEFV, TNF
29accessory nerve disease11.0IL10, TLR4, TNF
30gastroduodenal crohn's disease11.0NOD2, TLR4, TNF
31keratosis11.0IL10, NOD2, TLR4, TNF
32corneal intraepithelial neoplasm11.0HLA-B, IL10, TLR4, TNF
33nephrosclerosis11.0MEFV, TNF, TNFRSF1A
34bartonellosis11.0IL10, TLR4, TNF
35orbital periostitis11.0HLA-B, IL10, TNF
36uterine inversion11.0IL10, TLR4, TNF, TNFRSF1A
37binocular vision disease11.0IL10, TLR4, TNF
38primary biliary cirrhosis11.0IL10, LTA, TNF, TNFRSF1A
39perianal skin paget's disease11.0IL10, NOD2, TLR4, TNF
40alopecia11.0IL10, TNF, TNFRSF1A
416q terminal deletion syndrome11.0IL10, TNF
42lacrimal system cancer11.0FAS, NOD2, TNF
43mediastinum seminoma11.0CCR1, IL10, LTA
44benign peritoneal mesothelioma11.0MEFV, TNF, TNFRSF1A
45retinal vasculitis11.0
46magic syndrome11.0
47retroperitoneal fibrosis11.0IL10, TLR4, TNF
48subendocardial infarction acute myocardial infarction11.0IL10, IL12RB2, TNF
49neonatal period electroclinical syndrome11.0IL10, TLR4, TNF
50esophagus melanoma11.0IL10, TLR4, TNF

Graphical network of the top 20 diseases related to Behcet Syndrome:



Diseases related to behcet syndrome

Symptoms & Phenotypes for Behcet Syndrome

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Symptoms by clinical synopsis from OMIM:

109650

Clinical features from OMIM:

109650

Human phenotypes related to Behcet Syndrome:

 64 54 (show all 89)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia64 54 hallmark (90%) Very frequent (99-80%) HP:0000613
2 meningitis64 54 hallmark (90%) Very frequent (99-80%) HP:0001287
3 arthritis64 54 hallmark (90%) Very frequent (99-80%) HP:0001369
4 nausea and vomiting64 54 hallmark (90%) Very frequent (99-80%) HP:0002017
5 migraine64 54 hallmark (90%) Very frequent (99-80%) HP:0002076
6 vasculitis64 54 hallmark (90%) Very frequent (99-80%) HP:0002633
7 myalgia64 54 hallmark (90%) Very frequent (99-80%) HP:0003326
8 abnormality of temperature regulation64 hallmark (90%) HP:0004370
9 orchitis64 54 hallmark (90%) Very frequent (99-80%) HP:0100796
10 acne64 54 typical (50%) Frequent (79-30%) HP:0001061
11 gait disturbance64 54 typical (50%) Frequent (79-30%) HP:0001288
12 abdominal pain64 54 typical (50%) Frequent (79-30%) HP:0002027
13 gastrointestinal hemorrhage64 54 typical (50%) Frequent (79-30%) HP:0002239
14 arthralgia64 54 typical (50%) Frequent (79-30%) HP:0002829
15 reduced consciousness/confusion64 typical (50%) HP:0004372
16 hemiplegia/hemiparesis64 typical (50%) HP:0004374
17 thrombophlebitis64 typical (50%) HP:0004418
18 abnormal blistering of the skin64 54 typical (50%) Frequent (79-30%) HP:0008066
19 immunologic hypersensitivity64 54 typical (50%) Frequent (79-30%) HP:0100326
20 renal insufficiency64 54 occasional (7.5%) Occasional (29-5%) HP:0000083
21 retinopathy64 54 occasional (7.5%) Occasional (29-5%) HP:0000488
22 visual impairment64 occasional (7.5%) HP:0000505
23 cataract64 54 occasional (7.5%) Occasional (29-5%) HP:0000518
24 keratoconjunctivitis sicca64 54 occasional (7.5%) Occasional (29-5%) HP:0001097
25 seizures64 54 occasional (7.5%) Occasional (29-5%) HP:0001250
26 polyneuropathy64 occasional (7.5%) HP:0001271
27 hyperreflexia64 54 occasional (7.5%) Occasional (29-5%) HP:0001347
28 abnormality of the mitral valve64 occasional (7.5%) HP:0001633
29 abnormality of the myocardium64 54 occasional (7.5%) Occasional (29-5%) HP:0001637
30 abnormality of the aortic valve64 occasional (7.5%) HP:0001646
31 coronary artery disease64 occasional (7.5%) HP:0001677
32 abnormality of the pericardium64 occasional (7.5%) HP:0001697
33 pancreatitis64 54 occasional (7.5%) Occasional (29-5%) HP:0001733
34 splenomegaly64 54 occasional (7.5%) Occasional (29-5%) HP:0001744
35 weight loss64 54 occasional (7.5%) Occasional (29-5%) HP:0001824
36 malabsorption64 54 occasional (7.5%) Occasional (29-5%) HP:0002024
37 anorexia64 54 occasional (7.5%) Occasional (29-5%) HP:0002039
38 abnormality of the pleura64 occasional (7.5%) HP:0002103
39 hemoptysis64 54 occasional (7.5%) Occasional (29-5%) HP:0002105
40 pulmonary infiltrates64 54 occasional (7.5%) Occasional (29-5%) HP:0002113
41 pulmonary embolism64 54 occasional (7.5%) Occasional (29-5%) HP:0002204
42 incoordination64 occasional (7.5%) HP:0002311
43 vertigo64 54 occasional (7.5%) Occasional (29-5%) HP:0002321
44 memory impairment64 54 occasional (7.5%) Occasional (29-5%) HP:0002354
45 developmental regression64 54 occasional (7.5%) Occasional (29-5%) HP:0002376
46 encephalitis64 54 occasional (7.5%) Occasional (29-5%) HP:0002383
47 increased intracranial pressure64 54 occasional (7.5%) Occasional (29-5%) HP:0002516
48 cerebral ischemia64 54 occasional (7.5%) Occasional (29-5%) HP:0002637
49 lymphadenopathy64 54 occasional (7.5%) Occasional (29-5%) HP:0002716
50 paresthesia64 54 occasional (7.5%) Occasional (29-5%) HP:0003401
51 abnormality of the endocardium64 occasional (7.5%) HP:0004306
52 arterial thrombosis64 54 occasional (7.5%) Occasional (29-5%) HP:0004420
53 cranial nerve paralysis64 54 occasional (7.5%) Occasional (29-5%) HP:0006824
54 abnormal pyramidal signs64 54 occasional (7.5%) Occasional (29-5%) HP:0007256
55 aseptic necrosis64 54 occasional (7.5%) Occasional (29-5%) HP:0010885
56 myositis64 54 occasional (7.5%) Occasional (29-5%) HP:0100614
57 retrobulbar optic neuritis64 54 occasional (7.5%) Occasional (29-5%) HP:0100654
58 gangrene64 54 occasional (7.5%) Occasional (29-5%) HP:0100758
59 glomerulopathy64 54 occasional (7.5%) Occasional (29-5%) HP:0100820
60 epididymitis64 HP:0000031
61 oral ulcer64 54 Very frequent (99-80%) HP:0000155
62 irritability64 54 Occasional (29-5%) HP:0000737
63 iridocyclitis64 HP:0001094
64 iritis64 HP:0001101
65 alopecia areata64 HP:0002229
66 superficial thrombophlebitis64 HP:0002638
67 genital ulcers64 HP:0003249
68 erythema64 HP:0010783
69 chorioretinitis64 HP:0012424
70 behavioral abnormality54 Occasional (29-5%)
71 ataxia54 Occasional (29-5%)
72 hemiparesis54 Frequent (79-30%)
73 subcutaneous nodule54 Very frequent (99-80%)
74 mitral regurgitation54 Occasional (29-5%)
75 aortic regurgitation54 Occasional (29-5%)
76 pericarditis54 Occasional (29-5%)
77 pleuritis54 Occasional (29-5%)
78 pleural effusion54 Occasional (29-5%)
79 venous thrombosis54 Frequent (79-30%)
80 recurrent aphthous stomatitis54 Very frequent (99-80%)
81 fatigue54 Very frequent (99-80%)
82 increased inflammatory response54 Frequent (79-30%)
83 optic neuritis54 Occasional (29-5%)
84 blindness54 Occasional (29-5%)
85 confusion54 Frequent (79-30%)
86 myocardial infarction54 Occasional (29-5%)
87 fever54 Very frequent (99-80%)
88 endocarditis54 Occasional (29-5%)
89 papule54 Very frequent (99-80%)

UMLS symptoms related to Behcet Syndrome:


vasculitic rash, discharge from eye, snoring, pruritus, oral manifestations, halitosis, exanthema, chest pain

GenomeRNAi Phenotypes related to Behcet Syndrome according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-3510.3C4A, CCR1, IL10, TLR4

MGI Mouse Phenotypes related to Behcet Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.5FAS, IL10, IL12A, IL12RB2, IL23R, TLR4
2MP:000538810.5CCR1, FAS, IL10, IL12A, LTA, TLR4
3MP:000537910.5ERAP1, FAS, IL10, IL12RB2, IL23R, LTA
4MP:000537010.5CCR1, FAS, IL10, IL12RB2, LTA, MEFV
5MP:000536710.4CCR1, ERAP1, FAS, IL12RB2, STAT4, TLR4
6MP:000538110.3CCR1, FAS, IL10, IL12RB2, IL23R, NOD2
7MP:000538710.2CCR1, ERAP1, FAS, IL10, IL12A, IL12RB2
8MP:000539710.2CCR1, ERAP1, FAS, IL10, IL12A, IL12RB2
9MP:000537610.2CCR1, FAS, IL10, IL12A, IL12RB2, IL23R

Drugs & Therapeutics for Behcet Syndrome

About this section

Drugs for Behcet Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 76)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Prednisoloneapproved, vet_approvedPhase 4, Phase 3, Phase 2115350-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
2
Methylprednisoloneapproved, vet_approvedPhase 4, Phase 3, Phase 2115383-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
3
Fluocinolone Acetonideapproved, investigational, vet_approvedPhase 44067-73-26215
Synonyms:
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
4b,12-Difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
6-alpha,9-alpha-Difluoro-16-alpha-hydroxyprednisolone 16,17-acetonide
6.Alpha., 9.alpha.-Difluoro-16.alpha.-h
6.Alpha.,9-Difluoro
6.alpha.,9-Difluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
6.alpha.,9.alpha.-Difluoro-16.alpha.-hydroxyprednisolone 16,17-acetonide
6.alpha.-Fluorotriamcinolone acetonide
67-73-2
6a,9a-difluoro-16a-hydroxyprednisolone 16,17-acetonide
6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone
6alpha,9alpha-Difluoro-11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
6alpha,9alpha-Difluoro-11beta,16alpha,17alpha,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-Acetonide
6alpha,9alpha-Difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
6alpha,9alpha-difluoro-16alpha-hydroxyprednisolone 16,17-acetonide
6alpha-Fluorotriamcinolone acetonide
6alpha-fluorotriamcinolone acetonide
6α,9α-difluoro-16α-hydroxyprednisolone 16,17-acetonide
6α-fluorotriamcinolone acetonide
AC-429
AC1L1M1L
AC1Q6ACL
AR-1H0758
Acetonida de fluocinolona
Acetonida de fluocinolona [INN-Spanish]
Acetonide de fluocinolone
Acetonide de fluocinolone [INN-French]
C24H30F2O6
CCRIS 3250
CHEMBL989
CID6215
CPD000058329
Coriphate
Cortiplastol
D01825
DB00591
Derma-smoothe/fs
Dermalar
Dermatin (steroid)
EINECS 200-668-5
F0657
F8880_FLUKA
F8880_SIGMA
FLUOCINOLONE ACETONIDE
FS
Flucinar
Flucinolone
Flucort
Fluocet
Fluocet (TN)
Fluocinolonacetonidum
Fluocinolone 16,17-acetonide
Fluocinolone acetonide (JP15/USP/INN)
Fluocinolone acetonide [DCIT]
Fluocinolone acetonide [USAN:INN:JAN]
Fluocinoloni acetonidum
Fluocinoloni acetonidum [INN-Latin]
 
Fluonid
Fluortriamcinolone Acetonide
Fluotrex
Fluovitif
Flupollon
Fs Shampoo
HMS2090I14
HSDB 3083
Jellin
LS-118443
Localyn
Localyn Syntex
MLS000028545
MLS001076276
Medidur
MolPort-002-528-328
NCGC00021301-04
NCI60_042042
NSC 92339
NSC92339
Neo-Synalar
Omniderm
Percutina
Pregna-1,4-diene-3,20-dione, 6.alpha.,9-difluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone (8CI)
Prodermin
RS 1401AT
RS-1401 AT
Radiocin
Retisert
Retisert (TN)
S2470_Selleck
SAM002564208
SMR000058329
STOCK1N-55828
Sinalar
Synalar
Synalar (TN)
Synalar-HP
Synamol
Synandone
Synandrone
Synemol
Synotic
Synsac
Tefunote
UNII-0CD5FD6S2M
WLN: T F5 E5 B666 GO IO RV AHTTTT&J A BF CQ E FVIQ H H OF -A&BHO -B&ACEF
ZINC03977981
acetónido de fluocinolona
acétonide de fluocinolone
component of Neo-Synalar
flucinolone
fluocinolon acetonid
fluocinolone 16,17-acetonide
fluocinoloni acetonidum
ydroxyprednisolone 16,17-acetonide
4Neuroprotective AgentsPhase 41672
5Methylprednisolone HemisuccinatePhase 4, Phase 3, Phase 21153
6Prednisolone acetatePhase 4, Phase 3, Phase 21153
7Prednisolone hemisuccinatePhase 4, Phase 3, Phase 21153
8Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 210355
9Protective AgentsPhase 47190
10Prednisolone phosphatePhase 4, Phase 3, Phase 21153
11Methylprednisolone acetatePhase 4, Phase 3, Phase 21153
12Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
13Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 412767
14HormonesPhase 413979
15Hormone AntagonistsPhase 412778
16AntiemeticsPhase 43888
17Antineoplastic Agents, HormonalPhase 45407
18Autonomic AgentsPhase 49774
19glucocorticoidsPhase 44920
20Gastrointestinal AgentsPhase 4, Phase 3, Phase 1, Phase 28109
21Omega 3 Fatty AcidNutraceuticalPhase 4969
22
Cyclosporineapproved, investigational, vet_approvedPhase 391579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
23
Etanerceptapproved, investigationalPhase 3397185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
24
Miconazoleapproved, investigational, vet_approvedPhase 3362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
25
AdalimumabapprovedPhase 3478331731-18-116219006
Synonyms:
331731-18-1
Adalimumab
Adalimumab (USAN/INN)
Adalimumab (genetical recombination)
 
Adalimumab (genetical recombination) (JAN)
D02597
Humira
Humira (TN)
Humira Pen
Ig gamma-1 chain C region
26
Apremilastapproved, investigationalPhase 3, Phase 264608141-41-911561674
Synonyms:
Apremilast
Apremilast (USAN)
Apremilastum
Aprémilast
CC-10004
 
CHEBI:558773
CHEMBL514800
CID11561674
D08860
N-[2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethyl]-1,3-dioxo-isoindol-4-yl]acetamide
N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
27
InfliximabapprovedPhase 3, Phase 1, Phase 2378170277-31-3
Synonyms:
 
Ig gamma-1 chain C region
Remicade
28AnalgesicsPhase 3, Phase 211287
29Anti-Inflammatory Agents, Non-SteroidalPhase 3, Phase 24295
30Pharmaceutical SolutionsPhase 3, Phase 17793
31Analgesics, Non-NarcoticPhase 3, Phase 26260
32Antirheumatic AgentsPhase 3, Phase 2, Phase 110627
33Calcineurin InhibitorsPhase 31597
34Anti-Infective AgentsPhase 3, Phase 221402
35Antifungal AgentsPhase 33615
36interferonsPhase 3, Phase 22137
37Dermatologic AgentsPhase 3, Phase 1, Phase 25674
38Antiviral AgentsPhase 3, Phase 29732
39Immunosuppressive AgentsPhase 3, Phase 212770
40Interferon-alphaPhase 3, Phase 21139
41Antibodies, MonoclonalPhase 3, Phase 23795
42Angiogenesis InhibitorsPhase 3, Phase 24143
43ImmunoglobulinsPhase 3, Phase 26045
44AntibodiesPhase 3, Phase 26045
45Anti-Bacterial AgentsPhase 3, Phase 210884
46Angiogenesis Modulating AgentsPhase 3, Phase 24072
47
MethotrexateapprovedPhase 215181959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
48
rituximabapprovedPhase 21654174722-31-710201696
Synonyms:
AntiCD20
IDEC-102
IDEC-C2B8
 
Ig gamma-1 chain C region
MabThera
Mabthera
Rituxan
rituximab
49
Daclizumabapproved, investigationalPhase 298152923-56-3
Synonyms:
 
Dacliximab
Daclizumab beta
50
AzathioprineapprovedPhase 2165446-86-62265
Synonyms:
446-86-6
55774-33-9 (hydrochloride salt)
6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine
6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine
6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine
6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin
6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]
6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine
6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine
6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine
6-(Methyl-p-nitro-5-imidazolyl)-thiopurine
6-(Methyl-p-nitro-5-imidazolyl)thiopurine
6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine
6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine
6-[(1-Methyl-4-nitroimidazol-5-yl)- thio] purine
6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine
6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine
A 4638
A2593_SIAL
A4638_SIAL
A4638_SIGMA
AB00443544
AB00443544-03
AC-4230
AC1L1DAL
AC1Q3Z1F
AI-981/34845012
AI3-50290
Azamun
Azamun [Czech]
Azanin
Azasan
Azasan (TN)
Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine
Azathioprin
Azathioprine (JP15/USP/INN)
Azathioprine Sodium
Azathioprine [USAN:INN:BAN:JAN]
Azathioprine sodium
Azathioprinum
Azathioprinum [INN-Latin]
Azathiopurine
Azatioprin
Azatioprina
Azatioprina [INN-Spanish]
Azothioprine
B. W. 57-322
BPBio1_000054
BRD-K32821942-001-05-6
BRD-K60324116-001-01-5
BSPBio_000048
BSPBio_001876
BW 57-322
BW 57322
BW-57-322
C06837
C9H7N7O2S
CAS-446-86-6
CBDivE_013132
CCRIS 62
CHEBI:2948
CHEMBL1542
CID2265
CPD000427366
Ccucol
ChemDiv1_002659
Cytostatics
D00238
DB00993
DivK1c_000586
EINECS 207-175-4
EU-0100027
FT-0083532
HMS1568C10
HMS1920E17
 
HMS2091K19
HMS501N08
HMS594I19
HSDB 7084
IDI1_000586
Immuran
Imuran
Imuran (TN)
Imuran (tn)
Imurek
Imurel
KBio1_000586
KBio2_000464
KBio2_002427
KBio2_003032
KBio2_004995
KBio2_005600
KBio2_007563
KBio3_001376
KBio3_002906
KBioGR_000646
KBioGR_002427
KBioSS_000464
KBioSS_002433
LS-123
Lopac-A-4638
Lopac0_000027
MLS001049307
Methylnitroimidazolylmercaptopurine
MolPort-000-745-914
MolPort-000-764-262
MolPort-003-665-485
Muran
NCGC00015060-01
NCGC00015060-02
NCGC00015060-04
NCGC00015060-12
NCGC00090836-01
NCGC00090836-02
NCGC00090836-03
NCGC00090836-04
NCGC00090836-05
NCGC00090836-06
NCGC00094593-01
NCGC00094593-02
NCGC00094593-03
NCI-C03474
NINDS_000586
NSC 39084
NSC-39084
NSC39084
Oprea1_375441
Oprea1_533384
Oprea1_633462
Prestwick0_000094
Prestwick1_000094
Prestwick2_000094
Prestwick3_000094
Prestwick_41
S1721_Selleck
SAM002589938
SDCCGMLS-0065415.P001
SMR000427366
SPBio_000255
SPBio_001987
SPECTRUM1500133
STK831906
STOCK1S-20293
STOCK1S-27186
Spectrum2_000068
Spectrum3_000308
Spectrum4_000243
Spectrum5_000848
Spectrum_000064
Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl)
UNII-MRK240IY2L
WLN: T56 BM DN FN HNJ IS- ET5N CNJ A1 DNW
ZINC04258316
[Methyl(nitroimidazolyl)mercaptopurine]
azathioprine
azatiopr in
cMAP_000046

Interventional clinical trials:

(show top 50)    (show all 55)
idNameStatusNCT IDPhase
1Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's DiseaseUnknown statusNCT00720928Phase 4
2The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's DiseaseUnknown statusNCT01306955Phase 4
3Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein LevelsTerminatedNCT00578578Phase 4
4Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB)Unknown statusNCT00167583Phase 3
5A Study of Adalimumab in Japanese Subjects With Intestinal Behçet's DiseaseCompletedNCT01243671Phase 3
6Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special LesionsCompletedNCT01532570Phase 3
7Phase III Study in Refractory Behcet's DiseaseCompletedNCT00995709Phase 3
8Efficacy of Humira in Behcet Patients With ArthritisCompletedNCT01497717Phase 3
9Phase 3b Safety and Efficacy Study of Apremilast to Treat Moderate to Severe Plaque-plaque PsoriasisCompletedNCT01690299Phase 3
10A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's DiseaseRecruitingNCT02505568Phase 3
11A Phase 3 Randomized, Double-blind Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in Subjects With Active Behcet's DiseaseRecruitingNCT02307513Phase 3
12Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease UveitisTerminatedNCT02258867Phase 3
13Efficacy of Gevokizumab in the Treatment of Patients With Behçet's Disease Uveitis (EYEGUARD™-B)TerminatedNCT01965145Phase 3
14Long-term Safety of Gevokizumab in the Treatment of Patients With Chronic Non-infectious Uveitis (EYEGUARD-X)TerminatedNCT02375685Phase 3
15An Open-label, Rollover Study Providing Continued Dosing of Gevokizumab in Order to Assess Long-term Gevokizumab Safety DataTerminatedNCT02258854Phase 3
16Colchicine Randomized Double-Blind Controlled Crossover Study in Behcet's DiseaseCompletedNCT00700297Phase 2
17A Study to Evaluate the Efficacy and Safety of Apremilast (CC-10004) in the Treatment of Behçet DiseaseCompletedNCT00866359Phase 2
18Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's DiseaseCompletedNCT00664599Phase 2
19Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's DiseaseCompletedNCT00483184Phase 2
20Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical StudyCompletedNCT02620618Phase 1, Phase 2
21HAT in Eye Complications of Behcet's DiseaseCompletedNCT00001865Phase 2
22Anakinra for Behcet s DiseaseCompletedNCT01441076Phase 1, Phase 2
23Ilaris (Canakinumab) in the Schnitzler SyndromeCompletedNCT01245127Phase 2
24Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) In Japanese Subjects With Moderate-To-Severe Plaque-Type PsoriasisCompletedNCT01988103Phase 2
251 Year Canakinumab Treatment in Behcet's Disease Patients With Neurologic or Vascular InvolvementRecruitingNCT02756650Phase 2
26Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory DiseasesRecruitingNCT01988506Phase 2
27Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet DiseaseNot yet recruitingNCT02648581Phase 2
28A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's DiseaseWithdrawnNCT01211977Phase 1, Phase 2
29Stem Cell Transplantation for the Treatment of Knee OsteoarthritisUnknown statusNCT00550524Phase 1
30Stem Cell Transplantation in Ocular Lesions of Behcet's DiseaseTerminatedNCT00550498Phase 1
31Hematopoietic Stem Cell Support in VasculitisTerminatedNCT00278512Phase 1
32Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's DiseaseUnknown statusNCT00931957
33Psychological Symptoms in Patients With Behcet's Disease by SCL90-RCompletedNCT00699985
34Behçet's Disease and Eosinophil Cationic ProteinCompletedNCT01584778
35MEVALONATE KINASE GENE MUTATIONS AND THEIR CLINICAL CORRELATIONS IN BEHÇET'S DISEASECompletedNCT01780363
36The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's DiseaseCompletedNCT01720628
37Biological Markers in Retinal VasculitisCompletedNCT00050492
38Educational Needs of Patients With Systemic VasculitisCompletedNCT02190929
39Uveitis Gene-Expression ProfilingCompletedNCT00874471
40Impact of Vasculitis on Employment and IncomeCompletedNCT02476292
41Vasculitis Illness Perception (VIP) StudyCompletedNCT02190916
42Reproductive Health in Men and Women With VasculitisCompletedNCT02176070
43Evaluation and Treatment of Patients With Inflammatory Eye DiseasesCompletedNCT00006188
44A Prospective, Mono-Country and Multi-center Study to Observe Safety and Effectiveness of Adalimumab in KoREan Intestinal Behcet's Disease(BD) PatientsRecruitingNCT02687828
45Immunogenetic Mechanisms in Behcet's DiseaseRecruitingNCT01109433
46Studies of the Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID / CAPS, DIRA, CANDLE, SAVI, CRMO, Still's Disease, Behcet's Disease, and Other Undifferentiated Autoinflammatory Diseases)RecruitingNCT00059748
47Vasculitis Pregnancy RegistryRecruitingNCT02593565
48Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin DiseasesRecruitingNCT01952275
49Uveitis/Intraocular Inflammatory Disease Biobank (iBank)RecruitingNCT02656381
50The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious UveitisRecruitingNCT02627209

Search NIH Clinical Center for Behcet Syndrome

Inferred drug relations via UMLS68/NDF-RT46:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Behcet Syndrome cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet Syndrome:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet Syndrome:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637


Cochrane evidence based reviews: behcet syndrome

Genetic Tests for Behcet Syndrome

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Anatomical Context for Behcet Syndrome

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MalaCards organs/tissues related to Behcet Syndrome:

36
Eye, Skin, Spinal cord, Brain, Bone, Neutrophil, T cells

Publications for Behcet Syndrome

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Articles related to Behcet Syndrome:

idTitleAuthorsYear
1
Delayed Vasospasm after Aneurysmal Subarachnoid Hemorrhage in Behcet Syndrome. (27114963)
2016
2
Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome: An Observational Study. (26554787)
2015
3
JAK2 (V617F) mutation is not associated with thrombosis in Behcet syndrome. (22203033)
2012
4
Summary of workshop on recurrent aphthous stomatitis and Behcet syndrome. (281401)
1978

Variations for Behcet Syndrome

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Clinvar genetic disease variations for Behcet Syndrome:

5
id Gene Variation Type Significance SNP ID Assembly Location
1NOD2NM_022162.2(NOD2): c.2446G> ASNVPathogenicrs886040969GRCh37Chr 16, 50746268: 50746268
2TNFRSF1ANM_001065.3(TNFRSF1A): c.463C> TSNVPathogenicrs886039866GRCh37Chr 12, 6442542: 6442542
3NOD2NM_022162.2(NOD2): c.2197G> TSNVPathogenicrs746055479GRCh38Chr 16, 50712108: 50712108
4NOD2NM_022162.2(NOD2): c.241C> GSNVPathogenicrs34936594GRCh37Chr 16, 50733566: 50733566
5NOD2NM_022162.2(NOD2): c.1045C> T (p.Leu349Phe)SNVPathogenicrs752615209GRCh38Chr 16, 50710956: 50710956
6PSTPIP1NM_003978.4(PSTPIP1): c.364G> A (p.Val122Ile)SNVPathogenicrs886041107GRCh37Chr 15, 77320202: 77320202
7PSTPIP1NM_003978.4(PSTPIP1): c.865G> C (p.Asp289His)SNVPathogenicrs774164456GRCh38Chr 15, 77032888: 77032888

Copy number variations for Behcet Syndrome from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1241985868351706856724Copy numberDEFA1Behcet''s disease

Expression for genes affiliated with Behcet Syndrome

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Search GEO for disease gene expression data for Behcet Syndrome.

Pathways for genes affiliated with Behcet Syndrome

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Pathways related to Behcet Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathwaysScoreTop Affiliating Genes
110.4NOD2, TNF, TNFRSF1A
210.4IL10, IL12RB2, STAT4
310.3FAS, TNF, TNFRSF1A
4
Show member pathways
10.3IL12A, IL12RB2, STAT4
510.3IL10, TLR4, TNF
610.3IL10, IL12A, TNF
7
Show member pathways
10.3LTA, TNF, TNFRSF1A
8
Show member pathways
10.3MEFV, NOD2, PSTPIP1, TNF
910.3IL12A, TLR4, TNF
1010.3IL12A, TLR4, TNF
1110.3IL10, IL12A, IL12RB2, STAT4
12
Show member pathways
10.3IL10, IL23R, STAT4, TNF
1310.3HLA-B, LTA, TNF, TNFRSF1A
1410.3IL10, IL12A, TLR4, TNF
1510.3IL10, IL12A, TLR4, TNF
1610.3LTA, TLR4, TNF, TNFRSF1A
1710.3LTA, TLR4, TNF, TNFRSF1A
1810.3FAS, IL10, IL12A, TNF
1910.3IL10, LTA, TLR4, TNF
2010.3IL10, IL12A, LTA, TNF
2110.3FAS, IL10, STAT4, TNF, TNFRSF1A
22
Show member pathways
10.3IL10, IL12A, IL12RB2, TNF, TNFRSF1A
23
Show member pathways
10.3IL10, IL12A, TLR4, TNF, TNFRSF1A
2410.3FAS, LTA, NOD2, TNF, TNFRSF1A
25
Show member pathways
10.3FAS, IL10, IL12A, TNF, TNFRSF1A
26
Show member pathways
10.2HLA-B, IL10, IL12A, LTA, TNF
27
Show member pathways
10.2FAS, LTA, TLR4, TNF, TNFRSF1A
2810.2C4A, IL10, IL12A, TLR4, TNF
2910.2IL10, IL12A, NOD2, TLR4, TNF, TNFRSF1A
3010.2IL10, IL12A, IL12RB2, IL23R, LTA, TNF
31
Show member pathways
10.2FAS, IL12A, LTA, TLR4, TNF, TNFRSF1A
32
Show member pathways
10.2FAS, IL10, IL12A, STAT4, TLR4, TNF
33
Show member pathways
10.1FAS, HLA-B, IL12A, LTA, TLR4, TNF
34
Show member pathways
10.1IL10, IL12A, IL12RB2, IL23R, LTA, STAT4
35
Show member pathways
10.1CCR1, FAS, IL10, IL12A, IL12RB2, IL23R
36
Show member pathways
10.0CCR1, FAS, IL10, IL12A, IL12RB2, IL23R
37
Show member pathways
10.0CCR1, FAS, IL10, IL12A, IL12RB2, IL23R
38
Show member pathways
10.0CCR1, FAS, IL10, IL12A, IL12RB2, IL23R
39
Show member pathways
9.9C4A, ERAP1, HLA-B, IL12A, IL12RB2, IL23R
40
Show member pathways
9.9C4A, FAS, HLA-B, IL10, IL12A, IL12RB2

GO Terms for genes affiliated with Behcet Syndrome

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Cellular components related to Behcet Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:000998611.0FAS, HLA-B, NOD2, TLR4, TNF, TNFRSF1A
2external side of plasma membraneGO:000989711.0CCR1, FAS, IL12RB2, TLR4, TNF
3extracellular spaceGO:000561510.9C4A, ERAP1, FAS, IL10, IL12A, LTA
4plasma membraneGO:00058869.9C4A, CCR1, ERAP1, FAS, HLA-B, IL12RB2

Biological processes related to Behcet Syndrome according to GeneCards Suite gene sharing:

(show all 44)
idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complex assemblyGO:007155011.1TNF, TNFRSF1A
2defense responseGO:000695211.1NOD2, TNF, TNFRSF1A
3negative regulation of interleukin-12 productionGO:003269511.1IL10, MEFV
4cellular response to mechanical stimulusGO:007126011.1FAS, TLR4, TNFRSF1A
5interferon-gamma productionGO:003260911.1IL12RB2, TLR4
6negative regulation of cytokine secretion involved in immune responseGO:000274011.1IL10, TNF
7positive regulation of ceramide biosynthetic processGO:200030411.1TNF, TNFRSF1A
8negative regulation of inflammatory responseGO:005072811.1IL10, MEFV, TNFRSF1A
9I-kappaB kinase/NF-kappaB signalingGO:000724911.1TLR4, TNF, TNFRSF1A
10extrinsic apoptotic signaling pathway via death domain receptorsGO:000862511.1FAS, TNF, TNFRSF1A
11necroptotic signaling pathwayGO:009752711.1FAS, TNF
12apoptotic signaling pathwayGO:009719011.1FAS, TLR4, TNF
13negative regulation of interleukin-17 productionGO:003270011.1IL12A, TLR4
14positive regulation of interleukin-17 productionGO:003274011.1IL23R, NOD2
15positive regulation of chronic inflammatory response to antigenic stimulusGO:000287611.1LTA, TNF
16extrinsic apoptotic signaling pathwayGO:009719111.1FAS, IL12A, TNF
17defense response to Gram-positive bacteriumGO:005083011.1IL12A, LTA, TNF
18positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292511.1LTA, TNF
19positive regulation of nitric-oxide synthase biosynthetic processGO:005177011.0NOD2, TLR4
20positive regulation of MHC class II biosynthetic processGO:004534811.0IL10, TLR4
21cellular response to lipopolysaccharideGO:007122211.0IL10, IL12A, TLR4, TNF
22positive regulation of NIK/NF-kappaB signalingGO:190122411.0NOD2, TNF
23negative regulation of interleukin-6 productionGO:003271511.0IL10, TLR4, TNF
24negative regulation of growth of symbiont in hostGO:004413011.0IL10, LTA, TNF
25positive regulation of interleukin-8 biosynthetic processGO:004541611.0TLR4, TNF
26positive regulation of NK T cell activationGO:005113511.0IL12A, IL23R
27regulation of establishment of endothelial barrierGO:190314011.0TNF, TNFRSF1A
28defense response to bacteriumGO:004274211.0IL10, NOD2, TLR4, TNF, TNFRSF1A
29positive regulation of lymphocyte proliferationGO:005067111.0IL12A, TLR4
30receptor biosynthetic processGO:003280011.0IL10, TNF
31positive regulation of T cell mediated cytotoxicityGO:000191611.0IL12A, IL23R
32positive regulation of tyrosine phosphorylation of Stat4 proteinGO:004252011.0IL12A, IL23R
33positive regulation of interleukin-6 productionGO:003275511.0NOD2, TLR4, TNF
34positive regulation of interleukin-8 productionGO:003275711.0NOD2, TLR4, TNF
35positive regulation of JNK cascadeGO:004633011.0NOD2, TLR4, TNF
36positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312311.0NOD2, TLR4, TNF, TNFRSF1A
37positive regulation of ERK1 and ERK2 cascadeGO:007037411.0CCR1, NOD2, TLR4, TNF
38positive regulation of osteoclast differentiationGO:004567211.0CCR1, IL23R, TNF
39response to glucocorticoidGO:005138411.0FAS, IL10, TNF
40immune responseGO:000695510.9CCR1, FAS, IL10, IL12A, TLR4, TNFRSF1A
41positive regulation of interferon-gamma productionGO:003272910.8IL12A, IL12RB2, IL23R, LTA, TLR4, TNF
42inflammatory responseGO:000695410.8C4A, CCR1, FAS, IL10, IL23R, MEFV
43response to lipopolysaccharideGO:003249610.7FAS, IL10, IL12A, IL12RB2, IL23R, LTA
44tumor necrosis factor-mediated signaling pathwayGO:003320910.3FAS, LTA, TNF, TNFRSF1A

Molecular functions related to Behcet Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 receptor bindingGO:000514310.8IL12A, IL23R
2cytokine activityGO:000512510.7IL10, IL12A, LTA, TNF
3tumor necrosis factor receptor bindingGO:000516410.3ERAP1, LTA, TNF

Sources for Behcet Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet