BD
MCID: BHC002
MIFTS: 76

Behcet's Disease (BD) malady

Rare diseases, Neuronal diseases, Eye diseases, Nephrological diseases, Bone diseases, Skin diseases, Cardiovascular diseases categories

Summaries for Behcet's Disease

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Behcet's Disease, also known as behcet syndrome, is related to vasculitis and aphthous stomatitis, and has symptoms including retrobulbar optic neuritis, neuritis/polyneuritis/multineuritis and transient cerebral ischemia/stroke. An important gene associated with Behcet's Disease is MEFV (Mediterranean fever), and among its related pathways are Immune response IL 12 signaling pathway and OX40 Pathway. The drug thalidomide and the compounds polyinosinic-polycytidylic acid and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are skeleton and liver/biliary system.

Disease Ontology:9 A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

NIH Rare Diseases:44 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is unknown.  treatment is symptomatic and supportive. last updated: 12/4/2009

NINDS:45 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Wikipedia:66 Beh more...

Description from OMIM:48 109650

Aliases & Classifications for Behcet's Disease

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 32LifeMap Discovery™, 22Genetics Home Reference, 63UMLS, 46Novoseek, 35MedlinePlus, 50Orphanet, 48OMIM, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

50
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

behcet's disease 9 44 45 32
behcet syndrome 9 44 22 63
behcet's syndrome 44 22 35
behçet disease 22 50 48
behcet disease 44 22 46
adamantiades-behcet disease 9 22
triple symptom complex 9 22
behcet triple symptom complex 22
old silk route disease 22
behet's syndrome 9
bd 44


External Ids:

Disease Ontology9 DOID:13241
ICD9CM28 136.1
NCIt41 C34416
OMIM48 109650
MeSH36 D001528
MESH via Orphanet37 D001528
ICD10 via Orphanet27 M35.2
SNOMED-CT via Orphanet60 310701003
UMLS via Orphanet64 C0004943

Related Diseases for Behcet's Disease

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Behcet's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.3RBP3, HLA-B, CTLA4, IFNA2, MEFV, SAG
2aphthous stomatitis30.2HLA-B
3encephalomyelitis30.1CCR5, IL10, STAT4, CTLA4, LTA
4stomatitis30.1IFNA2
5retinal vasculitis30.1SAG
6multiple sclerosis30.1SAG, LTA, CTLA4, IL10, IL18, CCR5
7familial mediterranean fever30.0NOD2, MEFV
8tuberculosis29.9IL10, SAG, TLR4, NOD2, IL18
9atherosclerosis29.8STAT4, TLR4, IL18, IL10, NOD2, CCR5
10binswanger's disease10.3
11dementia - subcortical10.3
12subcortical arteriosclerotic encephalopathy10.3
13bipolar disorder10.2
14cervicitis10.2
15panuveitis10.1IFNA2
16chorioretinitis10.1RBP3, SAG
17pleurisy10.1MEFV
18chronic infantile neurological cutaneous articular syndrome10.1IL18, MEFV
19rheumatic disease10.1CTLA4, MEFV, IL18
20polymyositis10.1CTLA4, CCR5, HLA-B
21acquired immunodeficiency syndrome10.1CCR5, HLA-B, KIR3DL1
22pulmonary sarcoidosis10.1LTA, CCR5, IL18
23primary biliary cirrhosis10.1HLA-B, CTLA4, LTA
24autoimmune thrombocytopenic purpura10.1IFNA2, IL18
25diamond-blackfan anemia10.1
26acute mountain sickness10.1
27bd syndrome10.1
28spasticity10.1
29filariasis10.1TLR4
30graves' disease10.1CTLA4, CCR5, HLA-B, LTA
31felty's syndrome10.1C4A
32polyarteritis nodosa10.1MEFV, IFNA2
33lupus erythematosus10.1IL18, C4A
34blau syndrome10.1NOD2, MEFV
35myelitis10.1
36hepatitis10.1IFNA2, IL18, HLA-B, LTA, CTLA4
37psoriatic arthritis10.1LTA, NOD2
38chronic lymphocytic leukemia10.1CTLA4, LTA, CCR5
39periodontal disease10.1TLR4, IL18, CTLA4
40pyoderma gangrenosum10.1MEFV, NOD2
41iga glomerulonephritis10.1C4A, CCR5, MEFV
42spondylitis10.1NOD2
43nephritis10.1IL18, LTA, C4A
44coronary artery disease10.1TLR4, IL18, LTA, CCR5
45mastitis10.1TLR4
46hepatitis b10.1IFNA2, SAG, KIR3DL1, HLA-B, TLR4
47dermatitis10.1CTLA4, IL18, NOD2
48immunodeficiency with hyper igm type 210.1LTA, CCR5, TLR4, HLA-B, KIR3DL1
49periodontitis10.1TLR4
50pouchitis10.1NOD2, TLR4

Graphical network of the top 20 diseases related to Behcet's Disease:



Diseases related to behcet's disease

Symptoms for Behcet's Disease

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Sources:
48OMIM, 50Orphanet
See all sources

Symptoms by clinical synopsis from OMIM:

109650

Clinical features from OMIM:

109650

Symptoms:

50 (show all 67)
  • retrobulbar optic neuritis
  • neuritis/polyneuritis/multineuritis
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • cranial nerves palsy
  • renal failure
  • renal glomerular defect/glomerulopathy
  • lymphadenopathy/polyadenopathies
  • gangrena/necrosis
  • pulmonary thromboembolism
  • arterial embolism/thrombosis
  • angor pectoris/myocardial infarction
  • encephalitis
  • ataxia/incoordination/trouble of the equilibrium
  • pyramidal syndrome
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • early death/lethality
  • osteonecrosis/bone infarction
  • myositis
  • anorexia
  • psychic/behavioural troubles
  • psychic/psychomotor regression/dementia/intellectual decline
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hypereflexia
  • troubles of memory/amnesia/hypermnesia
  • endocardium anomalies/fibroelastosis/endocarditis
  • asthenia/fatigue/weakness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • acne/acnea
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • venous thrombosis/phlebitis/thrombophlebitis
  • abnormal gait
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • fever/chilling
  • myalgia/muscular pain
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • vascularitis/vasculitides/arteritis
  • testes inflammation/orchitis
  • facial pain/cephalalgia/migraine
  • meningitis/meningeal syndrome
  • obnubilation/coma/lethargia/desorientation
  • articular/joint pain/arthralgia
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • hemoptysis
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • pancreatitis
  • intestinal perforation
  • severe allergic reaction/atopy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • xerophthalmia/dry eyes
  • cataract/lens opacification
  • retinopathy
  • visual loss/blindness/amblyopia
  • dizziness
  • malabsorption/chronic diarrhea/steatorrhea
  • photophobia

Drugs & Therapeutics for Behcet's Disease

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discovery™, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Behcet's Disease

Drug clinical trials:

Search ClinicalTrials for Behcet's Disease

Search NIH Clinical Center for Behcet's Disease

Search CenterWatch for Behcet's Disease

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637

Genetic Tests for Behcet's Disease

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Anatomical Context for Behcet's Disease

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Sources:
34MalaCards
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MalaCards organs/tissues related to Behcet's Disease:

34
Eye, Skin, Bone, Testes, T cells, Lung, Monocytes, Brain, Myeloid, Whole blood, Heart, Colon, Thalamus, Endothelial

Animal Models for Behcet's Disease or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Behcet's Disease:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7LTA, CTLA4, NOD2, IL10, MEFV, TLR4
2MP:00053709.6TLR4, MEFV, CCR5, IL12RB2, IL10, CTLA4
3MP:00053819.6TLR4, CCR5, IL12RB2, IL18, IL10, NOD2
4MP:00053919.5TLR4, SAG, CCR5, IL18, IL10, RBP3
5MP:00020069.5TLR4, CCR5, IL12RB2, IL23R, IL10
6MP:00053859.4TLR4, CCR5, IL12RB2, IL18, IL10, CTLA4
7MP:00036319.2HLA-B, TLR4, SAG, CCR5, IL18, IL10
8MP:00107689.1HLA-B, TLR4, STAT4, MEFV, CCR5, IL18
9MP:00053769.1TLR4, STAT4, MEFV, CCR5, IL12RB2, IL18
10MP:00053979.1LTA, HLA-B, TLR4, STAT4, MEFV, CCR5
11MP:00053879.1CCR5, MEFV, STAT4, TLR4, HLA-B, IL12RB2

Publications for Behcet's Disease

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Sources:
53PubMed
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Articles related to Behcet's Disease:

(show top 50)    (show all 281)
idTitleAuthorsYear
1
A case of Behcet's disease complicated by carotid-oesophageal fistula. (23776286)
2014
2
The impact of personality on quality of life and disease activity in patients with Behcet's disease: a pilot study. (24342057)
2013
3
Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease. (23325038)
2013
4
Anakinra treatment in drug-resistant Behcet's disease: a case series. (24305945)
2013
5
Behcet's disease presenting with sudden-onset paraplegia due to anterior spinal artery involvement: 1-year follow-up of rehabilitation in conjunction with medication. (22193225)
2013
6
Incidence, prevalence and clinical characteristics of Behcet's disease in southern Sweden. (23012468)
2013
7
Autoantibodies against complement C1q in patients with Behcet's disease: association with vascular involvement. (23564409)
2013
8
Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet's disease. (22476858)
2013
9
Successful long-term triple disease control by ustekinumab in a patient with Behcet's disease, psoriasis and hidradenitis suppurativa. (23148307)
2013
10
Does Behcet's disease associate with neuropathic pain syndrome and impaired well-being? (23001467)
2013
11
Successful treatment of extensive intestinal perforations from Behcet's disease involving the whole gut: a case report. (24164849)
2013
12
Acute meningitis in Behcet's disease. (23660120)
2013
13
Subclinical left and right ventricular systolic dysfunction in Behcet's disease: a combined tissue doppler and velocity vector imaging study. (22941470)
2013
14
Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: systematic review and meta-analyses of observational studies. (22240504)
2012
15
Visfatin levels in Behcet's disease. (21494798)
2012
16
CC chemokine receptor 5 polymorphism in Italian patients with Behcet's disease. (22966075)
2012
17
Mediterranean fever gene mutations in Greek patients with Behcet's disease. (22808562)
2012
18
Behcet's disease with aneurysm of internal iliac artery and percutaneous treatment. (22159243)
2012
19
Association of amyotrophic lateral sclerosis and Behcet's disease: is there a relationship? A multi-national case series. (22234492)
2012
20
Musculoskeletal Findings in Behcet's Disease. (21961082)
2012
21
Clinical characteristics of neuro-Behcet's disease in Japan: a multicenter retrospective analysis. (21935641)
2012
22
The frequency of MEFV gene mutations in Behcet's disease and their relation with clinical findings. (21901355)
2012
23
CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (22722994)
2012
24
Bilateral Knee Pain Associated with Bone Infarction in a Patient with Behcet's Disease. (23198245)
2012
25
Recurrent vulval ulceration: could it be Behcet's disease? (23033529)
2012
26
Cognitive impairment in neuro-Behcet's disease and multiple sclerosis: a comparative study. (22720779)
2012
27
Associations between eNOS polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (21957880)
2012
28
Management of extensive venous thrombosis following cardiac surgery in a patient with Behcet's disease. (22825866)
2012
29
Urokinase plasminogen activator receptor levels in Behcet's disease. (21470667)
2011
30
Obstruction of the superior vena cava and stenosis of the right brachiocephalic vein in a patient with Adamantiades-Behcet's disease. (24391429)
2011
31
Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran. (21816027)
2011
32
Endocardial fibroelastosis of the right ventricle and tricuspid valve in a young adult with Behcet's disease. (20202032)
2010
33
Narcolepsy and Behcet's disease: report of a Chinese-Taiwanese case. (20022557)
2010
34
Lack of association of two polymorphisms of IRF5 with Behcet's disease. (19816589)
2009
35
Inhibition of Behcet's disease by calcitonin. (19299090)
2009
36
TNF-alpha gene polymorphisms in Iranian Azeri Turkish patients with Behcet's Disease. (19774383)
2009
37
Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. (18411217)
2008
38
Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. (17343851)
2007
39
Oxidative stress in patients with Behcet's disease: I correlation with severity and clinical parameters. (17408439)
2007
40
Cytochrome P450 polymorphisms in patients with Behcet's disease. (17269966)
2007
41
Selective anterograde amnesia with thalamus and hippocampal lesions in neuro-Behcet's disease. (17412491)
2007
42
A case of Behcet's disease with scleromalacia perforans. (15840606)
2005
43
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
44
Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: successful treatment with intravenous cyclophosphamide. (15986085)
2005
45
Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. (15654837)
2005
46
HLA class I and class II genotyping in patients with Behcet's disease: a regional study of eastern part of Turkey. (15304011)
2004
47
Conn's syndrome associated with Behcet's disease. (12589107)
2003
48
Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease. (12068141)
2002
49
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
50
Anticardiolipin and anti-beta2-glycoprotein I antibodies in Behcet's disease. (9741545)
1998

Variations for Behcet's Disease

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Expression for genes affiliated with Behcet's Disease

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Behcet's Disease

Search GEO for disease gene expression data for Behcet's Disease.

Pathways for genes affiliated with Behcet's Disease

About this section
Sources:
51PathCards, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 31KEGG, 56Reactome, 39NCBI BioSystems Database
See all sources

Pathways related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2STAT4, IL12RB2
210.2IL10, LTA
3
Show member pathways
10.1IL23R, STAT4, TLR4
410.1C4A, TLR4, IL10
5
Show member pathways
10.1NOD2, IL18, MEFV
6
Show member pathways
10.1NOD2, IL18, TLR4
710.1IL10, IL18, TLR4
810.0TLR4, CTLA4, IL18
9
Show member pathways
10.0IFNA2, NOD2, IL18
10
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.9IL10, IL23R, IL18, STAT4
11
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.9IL10, STAT4, IFNA2, TLR4
129.9HLA-B, KIR2DL1, KIR3DL1, MICB
13
Show member pathways
9.9IFNA2, NOD2, HLA-B, IL18
14
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.9TLR4, NOD2, IFNA2, IL18
15
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.9IL18, STAT4, CCR5, IL12RB2
169.8IFNA2, IL18, IL10, LTA
17
Show member pathways
Type III interferon signaling39
9.8IL23R, IL12RB2, IL10, IFNA2, STAT4
189.7IL10, NOD2, IFNA2, TLR4, IL18
19
Show member pathways
9.7MICB, KIR3DL1, HLA-B, CTLA4, KIR2DL1
20
Show member pathways
9.7HLA-B, LTA, IFNA2, TLR4, IL18
21
Show member pathways
Immune response CD16 signaling in NK cells61
9.7HLA-B, KIR2DL1, MICB, KIR3DL1, IFNA2
22
Show member pathways
IL27-mediated signaling events39
9.6LTA, IL12RB2, IL10, IL18, STAT4, TLR4
23
Show member pathways
9.6STAT4, IFNA2, IL12RB2, LTA, IL10, IL18
24
Show member pathways
9.6IL18, IL23R, IL10, LTA, CCR5, IL12RB2
25
Show member pathways
9.4STAT4, CCR5, IL10, LTA, IL18, IL12RB2
26
Show member pathways
9.4CCR5, IL12RB2, STAT4, TLR4, NOD2, IL23R
27
Show member pathways
9.3TLR4, LTA, IL10, IL23R, IL18, IL12RB2
28
Show member pathways
9.3IL23R, IL18, IL12RB2, IFNA2, CCR5, TLR4
29
Show member pathways
9.0CTLA4, C4A, LTA, KIR2DL1, KIR3DL1, IL10

Compounds for genes affiliated with Behcet's Disease

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
See all sources

Compounds related to Behcet's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1polyinosinic-polycytidylic acid4610.4TLR4, HLA-B, IL10, IL18
22,5-oligoadenylate4610.3HLA-B, IL10, IFNA2, TLR4
3il-124610.3IL18, STAT4, IL10
4imiquimod46 62 30 1213.3TLR4, IFNA2, IL18, IL10
5indoleamine4610.3IL10, CTLA4, IL18
6ifn-alpha4610.2IFNA2, IL18, IL10, TLR4
7ccl346 3011.2IL10, IL18, TLR4, CCR5
8con a4610.2CTLA4, IL10, IL18, IFNA2
9lipoteichoic acid4610.2IL10, IL18, HLA-B, TLR4, LTA
10mycophenolate mofetil46 52 1212.2IL18, LTA, CTLA4, IL10
11allergens4610.2IL18, IL10, STAT4, TLR4, CTLA4
12ivig4610.2IL10, LTA, SAG, CCR5
13groalpha4610.2IL10, IL18, CCR5
14etanercept46 52 1212.2LTA, IL18, IFNA2, IL10
15latex4610.2HLA-B, IL18, CCR5, TLR4
16neopterin4610.2IL10, LTA, IL18, IFNA2
17thalidomide46 52 62 1213.2IFNA2, IL18, IL10, CTLA4
18ribavirin46 52 1212.1IL18, IFNA2, CCR5, HLA-B, IL10
19tgf beta14610.1TLR4, IL18, CTLA4, LTA, IL10
20tacrolimus46 52 1212.1HLA-B, TLR4, IL18, IL10, NOD2, CTLA4
21prednisolone46 30 1212.1IFNA2, IL18, IL10, NOD2, LTA
22simvastatin46 52 62 30 25 1215.1IL10, CCR5, IL18, TLR4
23mannose4610.1CCR5, NOD2, LTA, TLR4
24methionine4610.0MEFV, CCR5, IFNA2, RBP3, CTLA4
25vitamin d4610.0LTA, TLR4, IL10, CTLA4, CCR5
26ionomycin4610.0IL10, IL18, LTA, CTLA4
27cimetidine46 30 1212.0IL18, IL10, HLA-B
28diaminopimelic acid469.9NOD2, TLR4
29histamine46 30 2511.9TLR4, IL10, IFNA2, CCR5, IL18
30methotrexate52 46 1211.9IL10, IL18, TLR4, CTLA4
31endotoxin469.9MEFV, TLR4, LTA, HLA-B, IL10, C4A
32pge2469.9TLR4, SAG, IL18, CCR5, HLA-B, IL10
33rantes469.9HLA-B, TLR4, CCR5, IL18, CTLA4, LTA
34infliximab46 52 1211.9IL18, LTA, CTLA4, NOD2, IL10, IFNA2
35il 10469.9CTLA4, TLR4, CCR5, IL18, IL10, NOD2
36nitric oxide46 25 1211.8IL10, IL18, TLR4, HLA-B, LTA, NOD2
37aspartate469.8IFNA2, TLR4, IL10, HLA-B, CCR5, IL18
38vitamin a46 25 1211.8RBP3, IL18, IFNA2, SAG
39cholesterol46 30 25 1212.8LTA, IL18, HLA-B, TLR4, CCR5, CTLA4
40steroid469.8SAG, CTLA4, IL18, HLA-B, C4A, LTA
41oxygen46 2510.8IFNA2, SAG, IL18, HLA-B, NOD2, LTA
42zinc46 2510.7IFNA2, RBP3, KIR3DL1, IL18, HLA-B, TLR4
43dexamethasone46 52 30 1212.7IL10, HLA-B, LTA, CTLA4, IL18, CCR5
44cyclosporin a46 30 6211.7CCR5, LTA, IL10, IL18, HLA-B, TLR4
45retinoic acid46 2510.7HLA-B, TLR4, CCR5, IFNA2, RBP3, LTA
46threonine469.7SAG, C4A, CCR5, LTA, NOD2, CTLA4
47alanine469.6TLR4, SAG, CCR5, IFNA2, IL18, CTLA4
48lipid469.5CTLA4, KIR2DL1, LTA, KIR3DL1, HLA-B, SAG
49serine469.5TLR4, HLA-B, SAG, STAT4, CCR5, C4A
50tyrosine469.0IFNA2, LTA, HLA-B, CTLA4, KIR2DL1, KIR3DL1

GO Terms for genes affiliated with Behcet's Disease

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Behcet's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.9NOD2, MICB, CCR5, HLA-B
2external side of plasma membraneGO:0098979.8CTLA4, IL12RB2, CCR5, TLR4
3integral component of plasma membraneGO:0058879.5IL12RB2, KIR2DL1, CTLA4, CCR5, TLR4, HLA-B
4plasma membraneGO:0058868.9C4A, HLA-B, CTLA4, NOD2, KIR2DL1, KIR3DL1

Biological processes related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.5IL10, TLR4
2negative regulation of interleukin-12 productionGO:03269510.5NOD2, IL10, MEFV
3positive regulation of natural killer cell proliferationGO:03281910.5IL18, IL23R
4type 2 immune responseGO:04209210.5IL10, IL18
5positive regulation of interleukin-12 productionGO:03273510.5NOD2, IL23R, TLR4
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.5IL18, IL23R
7interferon-gamma productionGO:03260910.5IL12RB2, TLR4
8positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.5NOD2, TLR4
9positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.5NOD2, LTA
10negative regulation of interferon-gamma productionGO:03268910.5TLR4, IL10, NOD2
11negative regulation of tumor necrosis factor productionGO:03272010.5NOD2, IL10, TLR4
12positive regulation of interleukin-17 productionGO:03274010.4IL18, IL23R, NOD2
13negative regulation of growth of symbiont in hostGO:04413010.4LTA, NOD2, IL10
14T-helper 1 type immune responseGO:04208810.4TLR4, IL18
15detection of bacteriumGO:01604510.4HLA-B, NOD2
16negative regulation of B cell proliferationGO:03088910.4IL10, CTLA4
17positive regulation of interleukin-10 productionGO:03273310.4NOD2, TLR4
18defense response to bacteriumGO:04274210.3NOD2, IL10, TLR4
19cellular response to lipopolysaccharideGO:07122210.3TLR4, CCR5, IL10
20regulation of immune responseGO:05077610.3HLA-B, MICB, KIR3DL1, KIR2DL1
21defense response to Gram-negative bacteriumGO:05082910.3IL23R, TLR4
22positive regulation of NF-kappaB import into nucleusGO:04234610.3IL18, TLR4
23cytokine-mediated signaling pathwayGO:01922110.3HLA-B, STAT4, IFNA2, IL12RB2
24response to lipopolysaccharideGO:03249610.2LTA, NOD2, IL23R, IL12RB2, TLR4
25positive regulation of activated T cell proliferationGO:04210410.2IL18, IL23R
26positive regulation of interferon-gamma productionGO:03272910.2LTA, IL23R, IL18, IL12RB2, TLR4
27cell surface receptor signaling pathwayGO:00716610.2SAG, CCR5, IFNA2, IL12RB2
28negative regulation of interleukin-6 productionGO:03271510.1TLR4, IL10
29innate immune responseGO:04508710.1HLA-B, TLR4, MEFV, IFNA2, NOD2, C4A
30cell-cell signalingGO:00726710.0CCR5, IFNA2, IL18, IL10, LTA
31positive regulation of T cell mediated cytotoxicityGO:00191610.0HLA-B, IL23R
32inflammatory responseGO:0069549.8MEFV, CCR5, IFNA2, IL18, IL23R, IL10
33immune responseGO:0069559.8HLA-B, TLR4, CCR5, IL18, KIR3DL1, KIR2DL1

Molecular functions related to Behcet's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.8LTA, IL10, IL18, IFNA2

Products for genes affiliated with Behcet's Disease

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Sources for Behcet's Disease

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet