MCID: BHC002
MIFTS: 68

Behcet's Disease malady

Rare diseases, Neuronal diseases, Eye diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Aliases & Classifications for Behcet's Disease

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Sources:
30LifeMap Discovery®, 8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 21Genetics Home Reference, 61UMLS, 44Novoseek, 48Orphanet, 32MedlinePlus, 33MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Behcet's Disease:

Name: Behcet's Disease 30 8 42 43
Behcet Syndrome 8 42 21 61
Behcet's Syndrome 42 21 32
Behçet Disease 42 21 48
Behcet Disease 42 21 44
Adamantiades-Behcet Disease 8 21
 
Triple Symptom Complex 8 21
Behcet Triple Symptom Complex 21
Old Silk Route Disease 21
Behet's Syndrome 8
Bd 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000 (Japan),>1/1000 (Turkey); Age of onset: Adolescent,Adult,Childhood; Age of death: adult


External Ids:

Disease Ontology8 DOID:13241
MeSH33 D001528
NCIt39 C34416
ICD9CM27 136.1
Orphanet48 117
MESH via Orphanet34 D001528
ICD10 via Orphanet26 M35.2
UMLS via Orphanet62 C0004943

Summaries for Behcet's Disease

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MedlinePlus:32 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Behcet's Disease, also known as behcet syndrome, is related to aphthous stomatitis and retinal vasculitis, and has symptoms including abnormality of the oral cavity, photophobia and meningitis. An important gene associated with Behcet's Disease is MEFV (Mediterranean fever), and among its related pathways are Immune response IL 12 signaling pathway and OX40 Pathway. The drug thalidomide and the compounds polyinosinic-polycytidylic acid and 2,5-oligoadenylate have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are skeleton and liver/biliary system.

Disease Ontology:8 A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

NIH Rare Diseases:42 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is unknown.  treatment is symptomatic and supportive. last updated: 12/4/2009

NINDS:43 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Genetics Home Reference:21 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.

Wikipedia:64 Beh more...

Related Diseases for Behcet's Disease

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Diseases related to Behcet's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1aphthous stomatitis30.9HLA-B
2retinal vasculitis30.7SAG
3vasculitis30.7HLA-B, SAG, MEFV, IFNA2, RBP3, CTLA4
4stomatitis30.6IFNA2
5tuberculosis29.7TLR4, SAG, IL18, IL10, NOD2
6atherosclerosis29.4TLR4, STAT4, CCR5, IL18, IL10, NOD2
7panuveitis10.6IFNA2
8chorioretinitis10.5RBP3, SAG
9pleurisy10.5MEFV
10cinca syndrome10.5MEFV, IL18
11rheumatic disease10.5CTLA4, IL18, MEFV
12polymyositis10.5HLA-B, CCR5, CTLA4
13acquired immunodeficiency syndrome10.5HLA-B, CCR5, KIR3DL1
14pulmonary sarcoidosis10.5LTA, IL18, CCR5
15primary biliary cirrhosis10.5HLA-B, CTLA4, LTA
16thrombocytopenic purpura, autoimmune10.4IL18, IFNA2
17filariasis10.4TLR4
18graves' disease10.4HLA-B, CCR5, CTLA4, LTA
19polyarteritis nodosa10.4IFNA2, MEFV
20felty's syndrome10.4C4A
21lupus erythematosus10.4C4A, IL18
22blau syndrome10.4NOD2, MEFV
23hepatitis10.4HLA-B, IFNA2, IL18, CTLA4, LTA
24psoriatic arthritis10.4NOD2, LTA
25chronic lymphocytic leukemia10.4LTA, CTLA4, CCR5
26periodontal disease10.4CTLA4, IL18, TLR4
27pyoderma gangrenosum10.3NOD2, MEFV
28spondylitis10.3NOD2
29iga glomerulonephritis10.3MEFV, CCR5, C4A
30bipolar disorder10.3
31binswanger's disease10.3
32dementia - subcortical10.3
33subcortical arteriosclerotic encephalopathy10.3
34mastitis10.3TLR4
35coronary artery disease10.3TLR4, CCR5, IL18, LTA
36nephritis10.3C4A, LTA, IL18
37hepatitis b10.3HLA-B, TLR4, SAG, IFNA2, KIR3DL1
38familial mediterranean fever, ar10.3NOD2, MEFV
39hiv-110.3HLA-B, TLR4, CCR5, KIR3DL1, LTA
40dermatitis10.3IL18, NOD2, CTLA4
41bd syndrome10.3
42periodontitis10.3TLR4
43pouchitis10.3NOD2, TLR4
44sezary's disease10.2IFNA2, STAT4
45primary hyperoxaluria10.2MEFV, IL18, CTLA4, LTA, C4A
46malaria10.2IL10, HLA-B
47spondyloarthropathy 110.2NOD2, TLR4, HLA-B
48selective iga deficiency disease10.2LTA, IL10
49cervicitis10.2
50lepromatous leprosy10.2IL10, LTA

Graphical network of the top 20 diseases related to Behcet's Disease:



Diseases related to behcet's disease

Symptoms for Behcet's Disease

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Symptoms:

 48 (show all 67)
  • photophobia
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • vascularitis/vasculitides/arteritis
  • testes inflammation/orchitis
  • facial pain/cephalalgia/migraine
  • meningitis/meningeal syndrome
  • myalgia/muscular pain
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • asthenia/fatigue/weakness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • acne/acnea
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • venous thrombosis/phlebitis/thrombophlebitis
  • abnormal gait
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • obnubilation/coma/lethargia/desorientation
  • articular/joint pain/arthralgia
  • severe allergic reaction/atopy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • xerophthalmia/dry eyes
  • cataract/lens opacification
  • retinopathy
  • visual loss/blindness/amblyopia
  • dizziness
  • malabsorption/chronic diarrhea/steatorrhea
  • intestinal perforation
  • pancreatitis
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • hemoptysis
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • endocardium anomalies/fibroelastosis/endocarditis
  • angor pectoris/myocardial infarction
  • arterial embolism/thrombosis
  • pulmonary thromboembolism
  • gangrena/necrosis
  • lymphadenopathy/polyadenopathies
  • renal glomerular defect/glomerulopathy
  • renal failure
  • cranial nerves palsy
  • retrobulbar optic neuritis
  • neuritis/polyneuritis/multineuritis
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • encephalitis
  • ataxia/incoordination/trouble of the equilibrium
  • pyramidal syndrome
  • hypereflexia
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • psychic/psychomotor regression/dementia/intellectual decline
  • troubles of memory/amnesia/hypermnesia
  • psychic/behavioural troubles
  • anorexia
  • myositis
  • osteonecrosis/bone infarction
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration

HPO human phenotypes related to Behcet's Disease:

(show all 69)
id Description Frequency HPO Source Accession
1 abnormality of the oral cavity hallmark (90%) HP:0000163
2 photophobia hallmark (90%) HP:0000613
3 meningitis hallmark (90%) HP:0001287
4 arthritis hallmark (90%) HP:0001369
5 nausea and vomiting hallmark (90%) HP:0002017
6 migraine hallmark (90%) HP:0002076
7 vasculitis hallmark (90%) HP:0002633
8 myalgia hallmark (90%) HP:0003326
9 abnormality of temperature regulation hallmark (90%) HP:0004370
10 orchitis hallmark (90%) HP:0100796
11 acne typical (50%) HP:0001061
12 gait disturbance typical (50%) HP:0001288
13 abdominal pain typical (50%) HP:0002027
14 gastrointestinal hemorrhage typical (50%) HP:0002239
15 arthralgia typical (50%) HP:0002829
16 reduced consciousness/confusion typical (50%) HP:0004372
17 hemiplegia/hemiparesis typical (50%) HP:0004374
18 thrombophlebitis typical (50%) HP:0004418
19 abnormal blistering of the skin typical (50%) HP:0008066
20 immunologic hypersensitivity typical (50%) HP:0100326
21 renal insufficiency occasional (7.5%) HP:0000083
22 retinopathy occasional (7.5%) HP:0000488
23 visual impairment occasional (7.5%) HP:0000505
24 cataract occasional (7.5%) HP:0000518
25 keratoconjunctivitis sicca occasional (7.5%) HP:0001097
26 seizures occasional (7.5%) HP:0001250
27 polyneuropathy occasional (7.5%) HP:0001271
28 hyperreflexia occasional (7.5%) HP:0001347
29 abnormality of the mitral valve occasional (7.5%) HP:0001633
30 abnormality of the myocardium occasional (7.5%) HP:0001637
31 abnormality of the aortic valve occasional (7.5%) HP:0001646
32 coronary artery disease occasional (7.5%) HP:0001677
33 abnormality of the pericardium occasional (7.5%) HP:0001697
34 pancreatitis occasional (7.5%) HP:0001733
35 splenomegaly occasional (7.5%) HP:0001744
36 weight loss occasional (7.5%) HP:0001824
37 malabsorption occasional (7.5%) HP:0002024
38 anorexia occasional (7.5%) HP:0002039
39 abnormality of the pleura occasional (7.5%) HP:0002103
40 hemoptysis occasional (7.5%) HP:0002105
41 pulmonary infiltrates occasional (7.5%) HP:0002113
42 pulmonary embolism occasional (7.5%) HP:0002204
43 incoordination occasional (7.5%) HP:0002311
44 vertigo occasional (7.5%) HP:0002321
45 memory impairment occasional (7.5%) HP:0002354
46 developmental regression occasional (7.5%) HP:0002376
47 encephalitis occasional (7.5%) HP:0002383
48 increased intracranial pressure occasional (7.5%) HP:0002516
49 cerebral ischemia occasional (7.5%) HP:0002637
50 lymphadenopathy occasional (7.5%) HP:0002716
51 paresthesia occasional (7.5%) HP:0003401
52 abnormality of the endocardium occasional (7.5%) HP:0004306
53 arterial thrombosis occasional (7.5%) HP:0004420
54 cranial nerve paralysis occasional (7.5%) HP:0006824
55 aseptic necrosis occasional (7.5%) HP:0010885
56 myositis occasional (7.5%) HP:0100614
57 retrobulbar optic neuritis occasional (7.5%) HP:0100654
58 gangrene occasional (7.5%) HP:0100758
59 glomerulopathy occasional (7.5%) HP:0100820
60 epididymitis HP:0000031
61 oral ulcer HP:0000155
62 irritability HP:0000737
63 iridocyclitis HP:0001094
64 iritis HP:0001101
65 arthritis HP:0001369
66 alopecia areata HP:0002229
67 superficial thrombophlebitis HP:0002638
68 genital ulcers HP:0003249
69 erythema HP:0010783

Drugs & Therapeutics for Behcet's Disease

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Drug clinical trials:

Search ClinicalTrials for Behcet's Disease

Search NIH Clinical Center for Behcet's Disease

Inferred drug relations via UMLS61/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637

Genetic Tests for Behcet's Disease

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Anatomical Context for Behcet's Disease

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MalaCards organs/tissues related to Behcet's Disease:

31
Eye, Skin, Bone, Testes, T cells, Lung, Monocytes, Brain, Neutrophil, Whole blood, Heart, Colon, Liver, Myeloid, Endothelial, Thalamus

Animal Models for Behcet's Disease or affiliated genes

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MGI Mouse Phenotypes related to Behcet's Disease:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.7CTLA4, NOD2, IL10, MEFV, LTA, TLR4
2MP:00053709.6CCR5, IL12RB2, IL10, CTLA4, LTA, MEFV
3MP:00053819.6NOD2, CCR5, TLR4, CTLA4, IL12RB2, IL18
4MP:00053919.5SAG, IL18, IL10, RBP3, LTA, CCR5
5MP:00020069.5IL10, TLR4, CCR5, IL12RB2, IL23R
6MP:00053859.4TLR4, LTA, CTLA4, IL10, IL18, IL12RB2
7MP:00036319.2HLA-B, TLR4, SAG, CCR5, IL18, IL10
8MP:00107689.1HLA-B, STAT4, TLR4, IL10, NOD2, CTLA4
9MP:00053769.1IL10, IL23R, CCR5, MEFV, STAT4, TLR4
10MP:00053979.1CCR5, LTA, CTLA4, NOD2, IL10, IL23R
11MP:00053879.1IL12RB2, IL18, IL23R, IL10, NOD2, CTLA4

Publications for Behcet's Disease

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Articles related to Behcet's Disease:

(show top 50)    (show all 288)
idTitleAuthorsYear
1
The saga of diagnostic/classification criteria in Behcet's disease. (25879654)
2015
2
Behcet's disease presenting with recurrent ocular, oral, and scrotal inflammatory lesions in a young Tanzanian man: a case report. (25356270)
2014
3
Acute inferior myocardial infarction in a young male patient associated with Behcet's disease and sildenafil. (24448432)
2014
4
A case of Behcet's disease complicated by carotid-oesophageal fistula. (23776286)
2014
5
The impact of personality on quality of life and disease activity in patients with Behcet's disease: a pilot study. (24342057)
2013
6
Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease. (23325038)
2013
7
Anakinra treatment in drug-resistant Behcet's disease: a case series. (24305945)
2013
8
Behcet's disease presenting with sudden-onset paraplegia due to anterior spinal artery involvement: 1-year follow-up of rehabilitation in conjunction with medication. (22193225)
2013
9
Incidence, prevalence and clinical characteristics of Behcet's disease in southern Sweden. (23012468)
2013
10
Autoantibodies against complement C1q in patients with Behcet's disease: association with vascular involvement. (23564409)
2013
11
Impact of the positive pathergy test on the performance of classification/diagnosis criteria for Behcet's disease. (22476858)
2013
12
Successful long-term triple disease control by ustekinumab in a patient with Behcet's disease, psoriasis and hidradenitis suppurativa. (23148307)
2013
13
Does Behcet's disease associate with neuropathic pain syndrome and impaired well-being? (23001467)
2013
14
Acute meningitis in Behcet's disease. (23660120)
2013
15
Subclinical left and right ventricular systolic dysfunction in Behcet's disease: a combined tissue doppler and velocity vector imaging study. (22941470)
2013
16
Relationships of HLA-B51 or B5 genotype with Behcet's disease clinical characteristics: systematic review and meta-analyses of observational studies. (22240504)
2012
17
Visfatin levels in Behcet's disease. (21494798)
2012
18
CC chemokine receptor 5 polymorphism in Italian patients with Behcet's disease. (22966075)
2012
19
Mediterranean fever gene mutations in Greek patients with Behcet's disease. (22808562)
2012
20
Behcet's disease with aneurysm of internal iliac artery and percutaneous treatment. (22159243)
2012
21
Association of amyotrophic lateral sclerosis and Behcet's disease: is there a relationship? A multi-national case series. (22234492)
2012
22
Musculoskeletal Findings in Behcet's Disease. (21961082)
2012
23
Clinical characteristics of neuro-Behcet's disease in Japan: a multicenter retrospective analysis. (21935641)
2012
24
The frequency of MEFV gene mutations in Behcet's disease and their relation with clinical findings. (21901355)
2012
25
CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (22722994)
2012
26
Bilateral Knee Pain Associated with Bone Infarction in a Patient with Behcet's Disease. (23198245)
2012
27
Recurrent vulval ulceration: could it be Behcet's disease? (23033529)
2012
28
Cognitive impairment in neuro-Behcet's disease and multiple sclerosis: a comparative study. (22720779)
2012
29
Associations between eNOS polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (21957880)
2012
30
Management of extensive venous thrombosis following cardiac surgery in a patient with Behcet's disease. (22825866)
2012
31
Urokinase plasminogen activator receptor levels in Behcet's disease. (21470667)
2011
32
Obstruction of the superior vena cava and stenosis of the right brachiocephalic vein in a patient with Adamantiades-Behcet's disease. (24391429)
2011
33
Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran. (21816027)
2011
34
Endocardial fibroelastosis of the right ventricle and tricuspid valve in a young adult with Behcet's disease. (20202032)
2010
35
Narcolepsy and Behcet's disease: report of a Chinese-Taiwanese case. (20022557)
2010
36
Lack of association of two polymorphisms of IRF5 with Behcet's disease. (19816589)
2009
37
Inhibition of Behcet's disease by calcitonin. (19299090)
2009
38
TNF-alpha gene polymorphisms in Iranian Azeri Turkish patients with Behcet's Disease. (19774383)
2009
39
Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. (18411217)
2008
40
Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. (17343851)
2007
41
Oxidative stress in patients with Behcet's disease: I correlation with severity and clinical parameters. (17408439)
2007
42
Cytochrome P450 polymorphisms in patients with Behcet's disease. (17269966)
2007
43
Selective anterograde amnesia with thalamus and hippocampal lesions in neuro-Behcet's disease. (17412491)
2007
44
A case of Behcet's disease with scleromalacia perforans. (15840606)
2005
45
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
46
Rapidly-progressive glomerulonephritis in a patient with Behcet's disease: successful treatment with intravenous cyclophosphamide. (15986085)
2005
47
Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. (15654837)
2005
48
HLA class I and class II genotyping in patients with Behcet's disease: a regional study of eastern part of Turkey. (15304011)
2004
49
Association of MICA polymorphism with HLA-B51 and disease severity in Korean patients with Behcet's disease. (12068141)
2002
50
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000

Variations for Behcet's Disease

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Expression for genes affiliated with Behcet's Disease

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Search GEO for disease gene expression data for Behcet's Disease.

Pathways for genes affiliated with Behcet's Disease

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Pathways related to Behcet's Disease according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2STAT4, IL12RB2
210.2IL10, LTA
3
Show member pathways
10.1IL23R, STAT4, TLR4
410.1C4A, TLR4, IL10
5
Show member pathways
10.1NOD2, IL18, MEFV
6
Show member pathways
10.1NOD2, IL18, TLR4
710.1IL10, IL18, TLR4
810.0TLR4, CTLA4, IL18
9
Show member pathways
10.0IFNA2, NOD2, IL18
10
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.9IL10, IL23R, IL18, STAT4
11
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.9IL10, STAT4, IFNA2, TLR4
129.9HLA-B, KIR2DL1, KIR3DL1, MICB
13
Show member pathways
9.9IFNA2, NOD2, HLA-B, IL18
14
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.9TLR4, NOD2, IFNA2, IL18
15
Show member pathways
Immune response IL 12 induced IFN gamma production59
9.9IL18, STAT4, CCR5, IL12RB2
169.8IFNA2, IL18, IL10, LTA
17
Show member pathways
Type III interferon signaling36
9.8IL23R, IL12RB2, IL10, IFNA2, STAT4
189.7IL10, NOD2, IFNA2, TLR4, IL18
19
Show member pathways
9.7MICB, KIR3DL1, HLA-B, CTLA4, KIR2DL1
20
Show member pathways
9.7HLA-B, LTA, IFNA2, TLR4, IL18
21
Show member pathways
Immune response CD16 signaling in NK cells59
9.7HLA-B, KIR2DL1, MICB, KIR3DL1, IFNA2
22
Show member pathways
IL27-mediated signaling events36
9.6LTA, IL12RB2, IL10, IL18, STAT4, TLR4
23
Show member pathways
9.6STAT4, IFNA2, IL12RB2, LTA, IL10, IL18
24
Show member pathways
9.6IL18, IL23R, IL10, LTA, CCR5, IL12RB2
25
Show member pathways
9.4STAT4, CCR5, IL10, LTA, IL18, IL12RB2
26
Show member pathways
9.4CCR5, IL12RB2, STAT4, TLR4, NOD2, IL23R
27
Show member pathways
9.3TLR4, LTA, IL10, IL23R, IL18, IL12RB2
28
Show member pathways
9.3IL23R, IL18, IL12RB2, IFNA2, CCR5, TLR4
29
Show member pathways
9.0CTLA4, C4A, LTA, KIR2DL1, KIR3DL1, IL10

Compounds for genes affiliated with Behcet's Disease

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Compounds related to Behcet's Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1polyinosinic-polycytidylic acid4410.4TLR4, HLA-B, IL10, IL18
22,5-oligoadenylate4410.3HLA-B, IL10, IFNA2, TLR4
3il-124410.3IL18, STAT4, IL10
4imiquimod44 60 28 1113.3TLR4, IFNA2, IL18, IL10
5indoleamine4410.3IL10, CTLA4, IL18
6ifn-alpha4410.2IFNA2, IL18, IL10, TLR4
7ccl344 2811.2IL10, IL18, TLR4, CCR5
8con a4410.2CTLA4, IL10, IL18, IFNA2
9lipoteichoic acid4410.2IL10, IL18, HLA-B, TLR4, LTA
10mycophenolate mofetil44 50 1112.2IL18, LTA, CTLA4, IL10
11allergens4410.2IL18, IL10, STAT4, TLR4, CTLA4
12ivig4410.2IL10, LTA, SAG, CCR5
13groalpha4410.2IL10, IL18, CCR5
14etanercept44 50 1112.2LTA, IL18, IFNA2, IL10
15latex4410.2HLA-B, IL18, CCR5, TLR4
16neopterin4410.2IL10, LTA, IL18, IFNA2
17thalidomide44 50 60 1113.2IFNA2, IL18, IL10, CTLA4
18ribavirin44 50 1112.1IL18, IFNA2, CCR5, HLA-B, IL10
19tgf beta14410.1TLR4, IL18, CTLA4, LTA, IL10
20tacrolimus44 50 1112.1HLA-B, TLR4, IL18, IL10, NOD2, CTLA4
21prednisolone44 28 1112.1IFNA2, IL18, IL10, NOD2, LTA
22simvastatin44 50 60 28 24 1115.1IL10, CCR5, IL18, TLR4
23mannose4410.1CCR5, NOD2, LTA, TLR4
24methionine4410.0MEFV, CCR5, IFNA2, RBP3, CTLA4
25vitamin d4410.0LTA, TLR4, IL10, CTLA4, CCR5
26ionomycin4410.0IL10, IL18, LTA, CTLA4
27cimetidine44 28 1112.0IL18, IL10, HLA-B
28diaminopimelic acid449.9NOD2, TLR4
29histamine44 28 2411.9TLR4, IL10, IFNA2, CCR5, IL18
30methotrexate50 44 1111.9IL10, IL18, TLR4, CTLA4
31endotoxin449.9MEFV, TLR4, LTA, HLA-B, IL10, C4A
32pge2449.9TLR4, SAG, IL18, CCR5, HLA-B, IL10
33rantes449.9HLA-B, TLR4, CCR5, IL18, CTLA4, LTA
34infliximab44 50 1111.9IL18, LTA, CTLA4, NOD2, IL10, IFNA2
35il 10449.9CTLA4, TLR4, CCR5, IL18, IL10, NOD2
36nitric oxide44 24 1111.8IL10, IL18, TLR4, HLA-B, LTA, NOD2
37aspartate449.8IFNA2, TLR4, IL10, HLA-B, CCR5, IL18
38vitamin a44 24 1111.8RBP3, IL18, IFNA2, SAG
39cholesterol44 28 24 1112.8LTA, IL18, HLA-B, TLR4, CCR5, CTLA4
40steroid449.8SAG, CTLA4, IL18, HLA-B, C4A, LTA
41oxygen44 2410.8IFNA2, SAG, IL18, HLA-B, NOD2, LTA
42zinc44 2410.7IFNA2, RBP3, KIR3DL1, IL18, HLA-B, TLR4
43dexamethasone44 50 28 1112.7IL10, HLA-B, LTA, CTLA4, IL18, CCR5
44cyclosporin a44 28 6011.7CCR5, LTA, IL10, IL18, HLA-B, TLR4
45retinoic acid44 2410.7HLA-B, TLR4, CCR5, IFNA2, RBP3, LTA
46threonine449.7SAG, C4A, CCR5, LTA, NOD2, CTLA4
47alanine449.6TLR4, SAG, CCR5, IFNA2, IL18, CTLA4
48lipid449.5CTLA4, KIR2DL1, LTA, KIR3DL1, HLA-B, SAG
49serine449.5TLR4, HLA-B, SAG, STAT4, CCR5, C4A
50tyrosine449.0IFNA2, LTA, HLA-B, CTLA4, KIR2DL1, KIR3DL1

GO Terms for genes affiliated with Behcet's Disease

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Cellular components related to Behcet's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.9NOD2, MICB, CCR5, HLA-B
2external side of plasma membraneGO:00098979.8TLR4, CCR5, IL12RB2, CTLA4
3integral component of plasma membraneGO:00058879.5CTLA4, KIR2DL1, KIR3DL1, IL12RB2, CCR5, TLR4
4plasma membraneGO:00058868.9HLA-B, TLR4, CCR5, MICB, KIR3DL1, KIR2DL1

Biological processes related to Behcet's Disease according to GeneCards Suite gene sharing:

(show all 33)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:004534810.5IL10, TLR4
2negative regulation of interleukin-12 productionGO:003269510.5NOD2, IL10, MEFV
3positive regulation of granulocyte macrophage colony-stimulating factor productionGO:003272510.5IL23R, IL18
4type 2 immune responseGO:004209210.5IL10, IL18
5positive regulation of interleukin-12 productionGO:003273510.5IL23R, TLR4, NOD2
6interferon-gamma productionGO:003260910.5IL12RB2, TLR4
7positive regulation of nitric-oxide synthase biosynthetic processGO:005177010.5NOD2, TLR4
8positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.5NOD2, LTA
9positive regulation of natural killer cell proliferationGO:003281910.5IL18, IL23R
10negative regulation of interferon-gamma productionGO:003268910.5TLR4, IL10, NOD2
11negative regulation of tumor necrosis factor productionGO:003272010.5TLR4, NOD2, IL10
12positive regulation of interleukin-17 productionGO:003274010.4IL18, IL23R, NOD2
13negative regulation of growth of symbiont in hostGO:004413010.4IL10, NOD2, LTA
14T-helper 1 type immune responseGO:004208810.4IL18, TLR4
15detection of bacteriumGO:001604510.4HLA-B, NOD2
16negative regulation of B cell proliferationGO:003088910.4IL10, CTLA4
17positive regulation of interleukin-10 productionGO:003273310.4NOD2, TLR4
18defense response to bacteriumGO:004274210.3NOD2, TLR4, IL10
19cellular response to lipopolysaccharideGO:007122210.3TLR4, CCR5, IL10
20regulation of immune responseGO:005077610.3KIR3DL1, MICB, HLA-B, KIR2DL1
21defense response to Gram-negative bacteriumGO:005082910.3TLR4, IL23R
22positive regulation of NF-kappaB import into nucleusGO:004234610.3IL18, TLR4
23cytokine-mediated signaling pathwayGO:001922110.3IL12RB2, HLA-B, STAT4, IFNA2
24negative regulation of interleukin-6 productionGO:003271510.2IL10, TLR4
25response to lipopolysaccharideGO:003249610.2NOD2, LTA, IL23R, IL12RB2, TLR4
26positive regulation of interferon-gamma productionGO:003272910.2TLR4, LTA, IL12RB2, IL18, IL23R
27cell surface receptor signaling pathwayGO:000716610.2CCR5, SAG, IL12RB2, IFNA2
28positive regulation of activated T cell proliferationGO:004210410.1IL23R, IL18
29innate immune responseGO:004508710.1HLA-B, TLR4, MEFV, IFNA2, NOD2, C4A
30cell-cell signalingGO:000726710.0IL10, IFNA2, CCR5, LTA, IL18
31positive regulation of T cell mediated cytotoxicityGO:000191610.0IL23R, HLA-B
32inflammatory responseGO:00069549.8MEFV, CCR5, IFNA2, IL18, IL23R, C4A
33immune responseGO:00069559.8HLA-B, TLR4, CCR5, IL18, KIR3DL1, KIR2DL1

Molecular functions related to Behcet's Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.8LTA, IL10, IL18, IFNA2

Sources for Behcet's Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet