BD
MCID: BHC002
MIFTS: 76

Behcet's Disease (BD) malady

Neuronal diseases, Eye diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Summaries for Behcet's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 46OMIM, 32MalaCards
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MedlinePlus:33 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Behcet's Disease, also known as behcet syndrome, is related to vasculitis and multiple sclerosis, and has symptoms including retrobulbar optic neuritis, neuritis/polyneuritis/multineuritis and transient cerebral ischemia/stroke. An important gene associated with Behcet's Disease is MEFV (Mediterranean fever), and among its related pathways are Leishmaniasis and Akt Signaling. The drug thalidomide and the compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

Genetics Home Reference:21 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.

NIH Rare Diseases:42 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is unknown.  treatment is symptomatic and supportive. last updated: 12/4/2009

NINDS:43 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Description from OMIM:46 109650

Aliases & Classifications for Behcet's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

behcet's disease 8 42 43 30
behcet syndrome 8 42 21 60
behcet's syndrome 42 21 33
behçet disease 21 48 46
behcet disease 42 21 44
adamantiades-behcet disease 8 21
triple symptom complex 8 21
behcet triple symptom complex 21
old silk route disease 21
behet's syndrome 8
bd 42


External Ids:

Disease Ontology8 DOID:13241
MeSH34 D001528
OMIM46 109650
ICD9CM27 136.1
NCIt39 C34416
MESH via Orphanet35 D001528
ICD10 via Orphanet26 M35.2
SNOMED-CT via Orphanet57 310701003
UMLS via Orphanet61 C0004943

Related Diseases for Behcet's Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Behcet's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.1SAG, MBL2, CTLA4, HLA-B, MEFV, RBP3
2multiple sclerosis30.1IL18, IL10, LTA, STAT4, HLA-B, CTLA4
3encephalomyelitis30.1CCR5, CTLA4, IL10, LTA, STAT4
4glomerulonephritis29.9CCR5, MBL2
5atherosclerosis29.9MBL2, STAT4, IL10, IL18, NOD2, CCR5
6retinitis29.9SAG
7aphthous stomatitis29.9HLA-B
8meningitis29.9HLA-B, MBL2
9encephalitis29.9HLA-B, CCR5
10influenza29.9MBL2, CCR5, LTA, HLA-B
11adenocarcinoma29.9CCR5, HLA-B
12familial mediterranean fever29.9NOD2, MEFV
13tuberculosis29.9SAG, TLR4, IL10, IL18, NOD2, MBL2
14vascular disease29.8IL10
15binswanger's disease10.3
16dementia - subcortical10.3
17subcortical arteriosclerotic encephalopathy10.3
18diamond-blackfan anemia10.2
19bipolar disorder10.2
20cervicitis10.2
21myelitis10.1
22ulcerative stomatitis10.1
23rheumatoid arthritis10.0CCR5, TLR4, MBL2, CTLA4, STAT4, MEFV
24viral infectious disease10.0IL10, IL18, KIR3DL1, TLR4, CCR5, MBL2
25melanoma10.0HLA-B, CTLA4, KIR2DL1, SAG, TLR4, KIR3DL1
26arthritis10.0CTLA4, CCR5, TLR4, LTA, MEFV, HLA-B
27uveitis10.0CCR5, SAG, CTLA4, RBP3, LTA, IL10
28graves' disease10.0LTA, CTLA4, CCR5, HLA-B
29leukemia10.0MBL2, TLR4, HLA-B, LTA, KIR3DL1
30hepatitis10.0LTA, IL18, CTLA4, HLA-B
31asthma10.0STAT4, IL10, IL18, HLA-B, CTLA4, TLR4
32psoriasis10.0NOD2, KIR3DL1, CTLA4, HLA-B, LTA, IL10
33immunodeficiency with hyper igm type 210.0TLR4, LTA, KIR3DL1, HLA-B, CCR5
34sarcoidosis10.0LTA, IL12RB2, IL18, CCR5, NOD2
35primary biliary cirrhosis10.0MBL2, CTLA4, HLA-B, LTA
36graft versus host disease10.0IL18, IL10, LTA, CTLA4, KIR3DL1, CCR5
37coronary heart disease10.0TLR4, CCR5, IL18, LTA
38celiac disease10.0MICB, CTLA4
39polymyositis10.0CCR5, CTLA4, HLA-B
40adenoma10.0HLA-B, SAG, CTLA4, TLR4
41dermatitis10.0CTLA4, IL18, NOD2
42myeloma10.0HLA-B, LTA
43wegener's granulomatosis10.0CCR5, CTLA4
44diabetes mellitus10.0HLA-B, CTLA4
45myeloid leukemia10.0KIR3DL1, LTA, TLR4
46vitiligo10.0CTLA4, HLA-B
47myasthenia gravis10.0IL10, LTA, HLA-B, CTLA4, CCR5
48lupus nephritis10.0IL18, IL10, MBL2, CCR5, LTA
49pulmonary sarcoidosis10.0LTA, IL18, CCR5
50atopy10.0NOD2, IL18, IL10, IL12RB2, LTA, CTLA4

Graphical network of the top 20 diseases related to Behcet's Disease:



Diseases related to behcet's disease

Clinical Features for Behcet's Disease

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

109650

Clinical synopsis from OMIM:

109650

Symptoms:

48 (show all 67)
  • retrobulbar optic neuritis
  • neuritis/polyneuritis/multineuritis
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • cranial nerves palsy
  • renal failure
  • renal glomerular defect/glomerulopathy
  • lymphadenopathy/polyadenopathies
  • gangrena/necrosis
  • pulmonary thromboembolism
  • arterial embolism/thrombosis
  • angor pectoris/myocardial infarction
  • encephalitis
  • ataxia/incoordination/trouble of the equilibrium
  • pyramidal syndrome
  • arthritis/synovitis/synovial proliferation
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • early death/lethality
  • osteonecrosis/bone infarction
  • myositis
  • anorexia
  • psychic/behavioural troubles
  • psychic/psychomotor regression/dementia/intellectual decline
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hypereflexia
  • troubles of memory/amnesia/hypermnesia
  • endocardium anomalies/fibroelastosis/endocarditis
  • asthenia/fatigue/weakness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • acne/acnea
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • venous thrombosis/phlebitis/thrombophlebitis
  • abnormal gait
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • fever/chilling
  • myalgia/muscular pain
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • vascularitis/vasculitides/arteritis
  • testes inflammation/orchitis
  • facial pain/cephalalgia/migraine
  • meningitis/meningeal syndrome
  • obnubilation/coma/lethargia/desorientation
  • articular/joint pain/arthralgia
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • hemoptysis
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • pancreatitis
  • intestinal perforation
  • severe allergic reaction/atopy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • xerophthalmia/dry eyes
  • cataract/lens opacification
  • retinopathy
  • visual loss/blindness/amblyopia
  • dizziness
  • malabsorption/chronic diarrhea/steatorrhea
  • photophobia

Drugs & Therapeutics for Behcet's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Behcet's Disease

Drug clinical trials:

Search ClinicalTrials for Behcet's Disease

Search NIH Clinical Center for Behcet's Disease

Search CenterWatch for Behcet's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637

Genetic Tests for Behcet's Disease

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Anatomical Context for Behcet's Disease

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32MalaCards
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MalaCards organs/tissues related to Behcet's Disease:

32
Eye, Skin, Bone, Testes, T cells, Lung, Monocytes, Brain, Myeloid, Whole blood, Heart, Colon, Thalamus, Endothelial

Animal Models for Behcet's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Behcet's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5NOD2, CCR5, TLR4, MBL2, CTLA4, HLA-B
2MP:000538711.4HLA-B, CTLA4, MBL2, TLR4, CCR5, STAT4
3MP:000538411.3STAT4, HLA-B, CTLA4, TLR4, CCR5, MEFV
4MP:000537611.2STAT4, CTLA4, MBL2, TLR4, CCR5, MEFV
5MP:000537010.8CCR5, TLR4, CTLA4, MEFV, LTA, IL12RB2
6MP:000539110.7RBP3, SAG, TLR4
7MP:000538110.6CCR5, TLR4, CTLA4, IL12RB2, IL10, IL18

Publications for Behcet's Disease

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Sources:
50PubMed
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Articles related to Behcet's Disease:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Behcet's disease presenting with sudden-onset paraplegia due to anterior spinal artery involvement: 1-year follow-up of rehabilitation in conjunction with medication. (22193225)
2013
2
Incidence, prevalence and clinical characteristics of Behcet's disease in southern Sweden. (23012468)
2013
3
Autoantibodies against complement C1q in patients with Behcet's disease: association with vascular involvement. (23564409)
2013
4
Successful treatment of extensive intestinal perforations from Behcet's disease involving the whole gut: a case report. (24164849)
2013
5
Acute meningitis in Behcet's disease. (23660120)
2013
6
FUT2: filling the gap between genes and environment in Behcet's disease? (24326010)
2013
7
A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis. (23928854)
2013
8
Genetic and non-genetic factors affecting the visual outcome of ocular Behcet's disease. (23831258)
2013
9
Behcet's disease associated with malignancy: a report of 41 Chinese cases. (24354961)
2013
10
The role of TLR2 and 4 in Behcet's disease pathogenesis. (23940075)
2013
11
Expression of regulatory receptors on I^I' T Cells and their cytokine production in Behcet's disease. (23336215)
2013
12
Genetic variants in the JAK1 gene confer higher risk of Behcet's disease with ocular involvement in Han Chinese. (23674219)
2013
13
Clinical characteristics of neuro-Behcet's disease in Japan: a multicenter retrospective analysis. (21935641)
2012
14
Cognitive impairment in neuro-Behcet's disease and multiple sclerosis: a comparative study. (22720779)
2012
15
Behcet's disease and IgA nephropathy. (21785954)
2012
16
Left atrial volume and function in patients with Behcet's disease assessed by real-time three-dimensional echocardiography. (22271104)
2012
17
Regression of severe Behcet's eye disease with infliximab therapy; .first two cases treated in Pakistan. (23866421)
2012
18
Association analysis of TGFBR3 gene with Vogt-Koyanagi-Harada disease and Behcet's disease in the Chinese Han population. (22440163)
2012
19
Evaluation of endothelial functions in patients with Behcet's disease without overt vascular involvement. (23363898)
2012
20
Multifocal venous thrombosis in Behcet's disease. (23146858)
2012
21
Correlation of DEFA1 gene copy number variation with intestinal involvement in Behcet's disease. (22219625)
2012
22
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease. (23082245)
2012
23
Obstruction of the superior vena cava and stenosis of the right brachiocephalic vein in a patient with Adamantiades-Behcet's disease. (24391429)
2011
24
There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations. (21873313)
2011
25
The determination of matrix metalloproteinase 9 activity and gene expression levels in Behcet's disease patients with aneurysmal complications. (20842516)
2011
26
Pentoxifylline for the treatment of anterior uveitis in Behcet's disease: possible alternative for TNF blockers. (20013266)
2011
27
Lack of an association of PD-1 and its ligand genes with Behcet's disease in a Chinese Han population. (22039410)
2011
28
CTLA4 gene polymorphisms and soluble CTLA4 protein in Behcet's disease. (19563524)
2009
29
Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-alpha level in patients with mucocutaneous type of Behcet's disease. (19434815)
2009
30
A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. (19614861)
2009
31
Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behcet's disease. (19208889)
2009
32
HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease. (17257316)
2007
33
LPS-stimulated production of TNF-alpha by peripheral blood monocytes in patients with Behcet's disease. (16897113)
2007
34
Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease. (17349875)
2007
35
Analysis of CD28 and CTLA-4 gene polymorphisms in Turkish patients with Behcet's disease. (17284227)
2007
36
Role of IL-12B promoter polymorphism in Adamantiades-Behcet's disease susceptibility: An involvement of Th1 immunoreactivity against Streptococcus Sanguinis antigen. (16514412)
2006
37
Four-digit allele genotyping of the HLA-A and HLA-B genes in Japanese patients with Behcet's disease by a PCR-SSOP-Luminex method. (16671946)
2006
38
Evaluation of leptin level and Ob gene polymorphism in patients with Behcet's disease. (16786343)
2006
39
Transverse myelitis after lumbar steroid injection in a patient with Behcet's disease. (16010282)
2005
40
A case of Behcet's disease with scleromalacia perforans. (15637046)
2005
41
Lipid profile and anticardiolipin antibodies in Behcet's disease. (15950080)
2005
42
Behcet's disease. (15599660)
2004
43
Secondary Amyloidosis, a Fatal Complication of Behcet's Disease: Three Case Reports. (18202468)
2004
44
Expression of KIR and C-type lectin receptors in Behcet's disease. (14679294)
2004
45
Cytokine production profile in patients with Behcet's disease treated with infliximab. (14596817)
2003
46
A case of nodular scleritis in association with Behcet's disease. (11417306)
2001
47
Characterization of T cells specific for an epitope of human 60-kD heat shock protein (hsp) in patients with Behcet's disease (BD) in Japan. (9158087)
1997
48
Behcet's disease: presentation with sagittal sinus thrombosis diagnosed noninvasively. (8742686)
1996
49
Multiple pulmonary arterial aneurysms in Behcet's disease and Hughes-Stovin syndrome. (7282759)
1981
50
Behcet's disease presenting as chronic aphthous stomatitis in a child. (693157)
1978

Genetic Variations for Behcet's Disease

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Expression for genes affiliated with Behcet's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Behcet's Disease

Search GEO for disease gene expression data for Behcet's Disease.

Pathways for genes affiliated with Behcet's Disease

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Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
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Pathways related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0NOD2, CCR5, TLR4, STAT4, IL12RB2, IL10
2
Hide members
11.0CCR5, TLR4, STAT4, LTA, IL12RB2, IL10
3
Hide members
11.0TLR4, MBL2, CTLA4, C4A, HLA-B, MEFV
4
Hide members
10.9CCR5, STAT4, LTA, IL12RB2, IL10, IL18
5
Hide members
10.9TLR4, STAT4, LTA, IL12RB2, IL10, IL18
6
Hide members
10.9CTLA4, HLA-B, LTA, IL12RB2, IL10, IL18
7
Hide members
10.8STAT4, LTA, IL12RB2, IL10, IL18
810.7IL23R, IL10, IL12RB2, STAT4
9
Hide members
10.7CCR5, TLR4, IL12RB2, IL23R
10
Development PDGF signaling via STATs and NF-kB
Hide members
10.7IL23R, IL18, IL10, STAT4
1110.7TLR4, IL10, IL18, NOD2
12
Hide members
10.7KIR3DL1, KIR2DL1, MICB, HLA-B
13
Hide members
10.7TLR4, HLA-B, LTA, IL18
14
Hide members
10.7CCR5, LTA, IL12RB2, IL23R
15
Hide members
10.7IL18, IL12RB2, STAT4, CCR5
1610.7TLR4, C4A, IL10
17
Hide members
10.7MEFV, IL18, NOD2
18
Hide members
10.7HLA-B, C4A, MBL2
19
Hide members
10.7KIR3DL1, KIR2DL1, MICB
2010.7IL18, CTLA4, TLR4
2110.7IL10, C4A, MBL2
2210.7LTA, IL10, IL18
23
Hide members
10.6IL23R, STAT4
2410.6IL18, TLR4

Compounds for genes affiliated with Behcet's Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Behcet's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.7SAG, MBL2, HLA-B, STAT4, CCR5, TLR4
2lipid4411.4TLR4, LTA, CTLA4, KIR3DL1, KIR2DL1, IL18
3nitric oxide44 11 2413.4MBL2, IL18, RBP3, HLA-B, TLR4, IL10
4il 104411.4NOD2, CTLA4, CCR5, TLR4, LTA, IL10
5serine4411.3NOD2, TLR4, CCR5, CTLA4, HLA-B, LTA
6lipoteichoic acid4411.3TLR4, IL18, IL10, LTA, HLA-B, MBL2
7infliximab44 49 1113.3NOD2, IL10, TLR4, CTLA4, LTA, IL18
8cholesterol44 28 11 2414.3HLA-B, LTA, CTLA4, MBL2, TLR4, IL18
9steroid4411.3IL18, C4A, LTA, HLA-B, CTLA4, SAG
10zinc44 2412.3KIR3DL1, HLA-B, CCR5, IL18, RBP3, TLR4
11vitamin d4411.3LTA, IL10, MBL2, CTLA4, CCR5, TLR4
12ribavirin44 49 1113.2HLA-B, IL10, MBL2, CCR5, IL18
13allergens4411.2IL10, IL18, TLR4, CTLA4, STAT4
14latex4411.2MBL2, TLR4, CCR5, HLA-B, IL18
15prednisolone44 28 1113.2MBL2, NOD2, IL18, IL10, LTA
16tgf beta14411.2TLR4, LTA, IL18, IL10, CTLA4
17mannose4411.2NOD2, MBL2, TLR4, CCR5, LTA
18rantes4411.2MBL2, TLR4, HLA-B, LTA
19cyclosporin a44 28 5913.2CTLA4, SAG, LTA, HLA-B
20con a4411.1IL10, IL18, MBL2, CTLA4
21polyinosinic-polycytidylic acid4411.1HLA-B, TLR4, IL10, IL18
22aspartate4411.1HLA-B, MBL2, SAG, CCR5
23peptidoglycan44 2812.1IL10, MBL2, NOD2, TLR4
24calcium44 49 11 2414.1NOD2, IL18, CTLA4, CCR5, TLR4, SAG
25polysaccharide4411.1TLR4, IL18, MBL2, CCR5, HLA-B
26ivig4411.1CCR5, LTA, SAG, IL10
27ccl344 2812.1CCR5, TLR4, IL18, IL10
28dexamethasone44 49 28 1114.1CTLA4, TLR4, LTA
29neopterin4411.1IL18, IL10, MBL2, LTA
30endotoxin4411.1C4A, MEFV
31paraffin4411.0SAG, MBL2, HLA-B, LTA, IL10
32tuberculin4411.0MBL2, IL10, IL18
33simvastatin44 49 59 28 11 2416.0IL10, TLR4, CCR5, IL18
34il-124411.0IL18, IL10, STAT4
35imiquimod44 28 59 1114.0IL10, TLR4, IL18
36polymyxin b4411.0IL10, MBL2, TLR4
37pge24411.0SAG
38oxygen44 2412.0SAG, MBL2, C4A
39groalpha4410.9IL18, CCR5, IL10
40ionomycin4410.9IL10, IL18, LTA, CTLA4
41tacrolimus44 49 1112.9CTLA4
42etanercept44 49 1112.9IL10, LTA, IL18
432,5-oligoadenylate4410.9HLA-B, TLR4
44mycophenolate mofetil44 49 1112.8IL10, CTLA4, IL18
45cimetidine44 28 1112.8HLA-B, IL18, IL10
46diaminopimelic acid4410.8TLR4, NOD2
47threonine4410.8CTLA4, NOD2, LTA, CCR5, SAG, C4A
48tarc4410.7IL18, IL10, CCR5
49pentoxifylline44 1111.7IL18, IL10, LTA
50isoleucine4410.4CCR5, MEFV, KIR3DL1

GO Terms for genes affiliated with Behcet's Disease

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16Gene Ontology
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Cellular components related to Behcet's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9IL18, IL10, LTA, RBP3, C4A, MBL2
2integral to plasma membraneGO:00588710.8KIR3DL1, KIR2DL1, IL12RB2, HLA-B, CTLA4, TLR4
3external side of plasma membraneGO:00989710.4CCR5, TLR4, CTLA4, IL12RB2

Biological processes related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.3CCR5, TLR4, CTLA4, HLA-B, IL18, KIR2DL1
2inflammatory responseGO:00695411.2CCR5, C4A, MEFV, IL10, IL18, IL23R
3positive regulation of interferon-gamma productionGO:03272911.2IL23R, IL18, IL12RB2, LTA, TLR4
4response to lipopolysaccharideGO:03249611.2TLR4, LTA, IL12RB2, IL23R, NOD2
5innate immune responseGO:04508711.1TLR4, MBL2, C4A, HLA-B, MEFV, NOD2
6negative regulation of growth of symbiont in hostGO:04413011.1MBL2, LTA, IL10, NOD2
7regulation of immune responseGO:05077611.1HLA-B, MICB, KIR2DL1, KIR3DL1
8defense response to bacteriumGO:04274211.1TLR4, MBL2, IL10, NOD2
9positive regulation of interleukin-17 productionGO:03274011.0IL18, IL23R, NOD2
10negative regulation of interleukin-12 productionGO:03269511.0NOD2, IL10, MEFV
11positive regulation of interleukin-12 productionGO:03273511.0NOD2, IL23R, TLR4
12negative regulation of interferon-gamma productionGO:03268911.0TLR4, IL10, NOD2
13negative regulation of tumor necrosis factor productionGO:03272011.0NOD2, IL10, TLR4
14positive regulation of tumor necrosis factor productionGO:03276011.0TLR4, IL18, NOD2
15defense response to Gram-positive bacteriumGO:05083011.0NOD2, LTA, MBL2
16type 2 immune responseGO:04209210.9IL18, IL10
17positive regulation of natural killer cell proliferationGO:03281910.9IL18, IL23R
18cellular response to lipopolysaccharideGO:07122210.8CCR5, TLR4, IL10
19positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.8IL18, IL23R
20positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, NOD2
21positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, TLR4
22cell-cell signalingGO:00726710.8CCR5, LTA, IL10, IL18
23interferon-gamma productionGO:03260910.8IL12RB2, TLR4
24positive regulation of interleukin-1 beta productionGO:03273110.7NOD2, IL18
25positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.6NOD2, TLR4
26detection of bacteriumGO:01604510.6NOD2, HLA-B
27T-helper 1 type immune responseGO:04208810.5TLR4, IL18
28negative regulation of B cell proliferationGO:03088910.3CTLA4, IL10

Products for genes affiliated with Behcet's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
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40NDF-RT
43NINDS
44Novoseek
46OMIM
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50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet