Behcet's Disease malady
Rare diseases, Neuronal diseases, Eye diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Skin diseases categories
Aliases & Descriptions for Behcet's Disease:
MalaCards categories: See all MalaCards categories (disease lists)
Global: Rare diseases
Anatomical: Neuronal diseases, Eye diseases, Cardiovascular diseases, Nephrological diseases, Bone diseases, Skin diseases
Rare neurological diseases
Rare eye diseases
Rare circulatory system diseases
Rare renal diseases
Rare systemic and rhumatological diseases
Rare skin diseases
Characteristics (Orphanet epidemiological data):51
Inheritance: Multigenic/multifactorial; Prevalence: 1-5/10000 (Japan),>1/1000 (Turkey); Age of onset: Adolescent,Adult,Childhood; Age of death: adult
NIH Rare Diseases:45 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. in some people, the disease also results in arthritis (swollen, painful, stiff joints), skin problems, and inflammation of the digestive tract, brain, and spinal cord. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is still unknown. treatment is symptomatic and supportive. experience is evolving with the use of interferon-alpha and with agents which inhibit tumor necrosis factor (tnf) in the treatment of behçet’s disease. behcet's disease is a lifelong disorder that comes and goes. spontaneous remission over time is common for individuals with behçet’s disease but permanent remission of symptoms has not been reported. last updated: 5/25/2015
MalaCards based summary: Behcet's Disease, also known as behcet syndrome, is related to vulvovaginal candidiasis and diabetes mellitus, insulin-dependent, and has symptoms including photophobia, meningitis and arthritis. An important gene associated with Behcet's Disease is HLA-B (Major Histocompatibility Complex, Class I, B), and among its related pathways are Th17 Differentiation and IL-10 Pathway. The drug thalidomide has been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related mouse phenotypes are liver/biliary system and hematopoietic system.
Disease Ontology:10 A vasculitis that is characterized by an autoimmune mediated inflammation of the blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.
MedlinePlus:35 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases
NINDS:46 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and
Genetics Home Reference:23 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.
Wikipedia:68 Behçet\'s disease or Behçet disease (/bɛˈtʃɛt/), sometimes called Behçet\'s syndrome, Morbus... more...
Symptoms:51 (show all 67)
HPO human phenotypes related to Behcet's Disease:(show all 70)
Drugs for Behcet's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 44)
Interventional clinical trials:(show top 50) (show all 60)
Search NIH Clinical Center for Behcet's Disease
Inferred drug relations via UMLS65/NDF-RT43:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
MalaCards organs/tissues related to Behcet's Disease:33
Skin, Eye, Brain, Spinal cord, Bone, Testes, T cells
MGI Mouse Phenotypes related to Behcet's Disease:38
Articles related to Behcet's Disease:(show top 50) (show all 304)
Search GEO for disease gene expression data for Behcet's Disease.
Pathways related to Behcet's Disease according to GeneCards Suite gene sharing:(show all 28)
Cellular components related to Behcet's Disease according to GeneCards Suite gene sharing:
Biological processes related to Behcet's Disease according to GeneCards Suite gene sharing:(show all 44)
Molecular functions related to Behcet's Disease according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet