BD
MCID: BHC002
MIFTS: 68

Behcet's Disease (BD) malady

Neuronal, Eye, Nephrological, Bone, Skin categories

Summaries for Behcet's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 21Genetics Home Reference, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Behcet's Disease, also known as behcet syndrome, is related to vasculitis and atherosclerosis, and has symptoms including photophobia, follicular/erythematous/edematous papules/milium and enanthema/aphtosa/aphta/leukoplakia. An important gene associated with Behcet's Disease is MEFV (Mediterranean fever), and among its related pathways are Leishmaniasis and Akt Signaling. The drug thalidomide and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

NIH Rare Diseases:43 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is unknown.  treatment is symptomatic and supportive. last updated: 12/4/2009

NINDS:44 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Genetics Home Reference:21 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.

Description from OMIM:47 109650

Aliases & Classifications for Behcet's Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 31LifeMap Discovery™, 21Genetics Home Reference, 61UMLS, 45Novoseek, 34MedlinePlus, 49Orphanet, 47OMIM, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Eye, Nephrological, Bone, Skin


Characteristics (Orphanet epidemiological data):

49
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

behcet's disease 8 43 44 31
behcet syndrome 8 43 21 61
behcet's syndrome 43 21 34
behcet disease 43 21 45
adamantiades-behcet disease 8 21
triple symptom complex 8 21
behçet disease 49 47
behcet triple symptom complex 21
old silk route disease 21
behet's syndrome 8
beh�et disease 21
bd 43


External Ids:

Disease Ontology8 DOID:13241
MeSH35 D001528
OMIM47 109650
ICD9CM27 136.1
NCIt40 C34416
MESH via Orphanet36 D001528
ICD10 via Orphanet26 M35.2
SNOMED-CT via Orphanet58 310701003
UMLS via Orphanet62 C0004943

Related Diseases for Behcet's Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Behcet's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.2SAG, MBL2, CTLA4, HLA-B, MEFV, RBP3
2atherosclerosis30.0CCR5, TLR4, MBL2, STAT4, IL10, IL18
3aphthous stomatitis29.9HLA-B
4adenocarcinoma29.9CCR5, HLA-B, NAT2
5tuberculosis29.9TLR4, SAG, MBL2, NAT2, IL10, IL18
6familial mediterranean fever29.9NOD2, MEFV
7vascular disease29.9IL10
8binswanger's disease10.3
9dementia - subcortical10.3
10subcortical arteriosclerotic encephalopathy10.3
11diamond-blackfan anemia10.2
12bipolar disorder10.2
13clostridium difficile10.2
14myelitis10.1
15acute mountain sickness10.1
16allergic encephalomyelitis10.1
17spasticity10.1
18rheumatoid arthritis10.0KIR2DL1, IL23R, IL18, IL10, NAT2, MICB
19viral infectious disease10.0CCR5, TLR4, MBL2, CTLA4, HLA-B, LTA
20type 1 diabetes10.0CCR5, CTLA4, HLA-B, LTA, IL18, KIR3DL1
21multiple sclerosis10.0CCR5, IL18, IL10, LTA, STAT4, HLA-B
22melanoma10.0CCR5, TLR4, SAG, CTLA4, HLA-B, MEFV
23hepatitis10.0CTLA4, HLA-B, LTA, NAT2, IL18
24ulcerative colitis10.0NOD2, IL23R, IL18, IL10, NAT2, MICB
25immunodeficiency with hyper igm type 210.0CCR5, TLR4, HLA-B, LTA, NAT2, KIR3DL1
26ipex syndrome10.0CCR5, MBL2, HLA-B, STAT4, LTA, NAT2
27asthma10.0CCR5, TLR4, MBL2, CTLA4, HLA-B, STAT4
28systemic lupus erythematosus10.0CCR5, TLR4, MBL2, CTLA4, STAT4, LTA
29arthritis10.0NOD2, IL18, IL10, LTA, MEFV, HLA-B
30leukemia10.0TLR4, MBL2, HLA-B, LTA, KIR3DL1
31psoriasis10.0KIR3DL1, IL23R, IL18, IL10, NAT2, LTA
32uveitis10.0NOD2, IL10, LTA, RBP3, HLA-B, CTLA4
33graves' disease10.0CCR5, CTLA4, HLA-B, LTA
34influenza10.0CCR5, MBL2, HLA-B, LTA
35adenoma10.0TLR4, SAG, CTLA4, HLA-B, NAT2
36sarcoidosis10.0CCR5, LTA, IL12RB2, IL18, NOD2
37breast cancer10.0CCR5, CTLA4, HLA-B, NAT2, KIR3DL1, NOD2
38primary biliary cirrhosis10.0MBL2, CTLA4, HLA-B, LTA
39primary hyperoxaluria10.0IL18, NAT2, LTA, MEFV, CTLA4
40sepsis10.0CCR5, TLR4, MBL2, RBP3, LTA, IL10
41coronary heart disease10.0CCR5, TLR4, LTA, IL18
42diabetes mellitus10.0CTLA4, HLA-B, NAT2
43graft versus host disease10.0CCR5, CTLA4, LTA, IL10, IL18, KIR3DL1
44hepatocellular carcinoma10.0KIR3DL1, NAT2, CTLA4, TLR4
45stomach cancer10.0TLR4, MBL2, LTA, NAT2
46celiac disease10.0MICB, CTLA4
47polymyositis10.0CCR5, CTLA4, HLA-B
48atopy10.0IL10, IL12RB2, NAT2, LTA, CTLA4, TLR4
49lupus erythematosus10.0NAT2, IL18
50endometriosis10.0NAT2, KIR3DL1

Graphical network of the top 20 diseases related to Behcet's Disease:



Diseases related to behcet's disease

Clinical Features for Behcet's Disease

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

109650

Clinical synopsis from OMIM:

109650

Symptoms:

49 (show all 67)
  • photophobia
  • follicular/erythematous/edematous papules/milium
  • enanthema/aphtosa/aphta/leukoplakia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • vascularitis/vasculitides/arteritis
  • testes inflammation/orchitis
  • facial pain/cephalalgia/migraine
  • meningitis/meningeal syndrome
  • myalgia/muscular pain
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • asthenia/fatigue/weakness
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • acne/acnea
  • acute abdominal pain/colic
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • venous thrombosis/phlebitis/thrombophlebitis
  • abnormal gait
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • obnubilation/coma/lethargia/desorientation
  • articular/joint pain/arthralgia
  • severe allergic reaction/atopy
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • xerophthalmia/dry eyes
  • cataract/lens opacification
  • retinopathy
  • visual loss/blindness/amblyopia
  • dizziness
  • malabsorption/chronic diarrhea/steatorrhea
  • intestinal perforation
  • pancreatitis
  • splenomegaly
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • hemoptysis
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • endocardium anomalies/fibroelastosis/endocarditis
  • angor pectoris/myocardial infarction
  • arterial embolism/thrombosis
  • pulmonary thromboembolism
  • gangrena/necrosis
  • lymphadenopathy/polyadenopathies
  • renal glomerular defect/glomerulopathy
  • renal failure
  • cranial nerves palsy
  • retrobulbar optic neuritis
  • neuritis/polyneuritis/multineuritis
  • transient cerebral ischemia/stroke
  • cranial hypertension
  • encephalitis
  • ataxia/incoordination/trouble of the equilibrium
  • pyramidal syndrome
  • hypereflexia
  • seizures/epilepsy/absences/spasms/status epilepticus
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • psychic/psychomotor regression/dementia/intellectual decline
  • troubles of memory/amnesia/hypermnesia
  • psychic/behavioural troubles
  • anorexia
  • myositis
  • osteonecrosis/bone infarction
  • early death/lethality
  • weight loss/loss of appetite/break in weight curve/general health alteration

Drugs & Therapeutics for Behcet's Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Behcet's Disease

Drug clinical trials:

Search ClinicalTrials for Behcet's Disease

Search NIH Clinical Center for Behcet's Disease

Search CenterWatch for Behcet's Disease

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637

Genetic Tests for Behcet's Disease

Anatomical Context for Behcet's Disease

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Behcet's Disease:

33
Bone marrow, Whole blood, Brain, Skin, Myeloid, Monocytes, T cells, B cells, Thalamus

Animal Models for Behcet's Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Behcet's Disease

Sources:
51PubMed
See all sources

Articles related to Behcet's Disease:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Mean platelet volume in recurrent aphthous stomatitis and behcet disease. (23766348)
2014
2
Anakinra treatment in drug-resistant Behcet's disease: a case series. (24305945)
2013
3
Behcet's disease presenting with sudden-onset paraplegia due to anterior spinal artery involvement: 1-year follow-up of rehabilitation in conjunction with medication. (22193225)
2013
4
Does Behcet's disease associate with neuropathic pain syndrome and impaired well-being? (23001467)
2013
5
A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis. (23928854)
2013
6
Behcet's disease simulating secondary syphilis in an HIV-infected patient. (23919062)
2013
7
Kimura's disease and Behcet's syndrome in the same family--are they associated? (22749664)
2013
8
Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease. (23472940)
2013
9
Successful Treatment of Vasculo-Behcet's Disease Presenting as Recurrent Pseudoaneurysms: the Importance of Medical Treatment. (23888260)
2013
10
Polymorphisms in the tumor necrosis factor gene and susceptibility to Behcet's disease: an updated meta-analysis. (24049437)
2013
11
Serum prolactin levels in BehAset's disease. Is there a relationship between Behcet's disease and prolactin as in other autoimmune diseases? (23683488)
2013
12
Psychiatric disorders and MRI brain findings in patients with systemic lupus erythematosus and Behcet's disease: A cross sectional study. (24435030)
2013
13
Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia. (24322831)
2013
14
Mean Platelet Volume: An Emerging Diagnostic Factor of Recurrent Aphthous Stomatitis and Behcet Disease. (24327766)
2013
15
CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (22722994)
2012
16
Cognitive impairment in neuro-Behcet's disease and multiple sclerosis: a comparative study. (22720779)
2012
17
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population. (22483685)
2012
18
Behcet's disease and focal segmental glomerulosclerosis: an unusual association. (21833522)
2012
19
Behcet's disease with superior vena cava syndrome related to pacemaker leads: a case report. (22600024)
2012
20
Regression of severe Behcet's eye disease with infliximab therapy; .first two cases treated in Pakistan. (23866421)
2012
21
Contribution of Hla-B51 in the susceptibility and specific clinical features of Behcet's disease in Tunisian patients. (22560383)
2012
22
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease. (23082245)
2012
23
Behcet's disease with active uveitis: detection of serum protein biomarkers using MALDI-TOF-MS. (22641412)
2012
24
Genome-wide pathway analysis of a genome-wide association study on psoriasis and Behcet's disease. (22201026)
2012
25
Investigation of bacterial and viral agents and immune status in Behcet's disease patients from Iran. (21816027)
2011
26
There is no association of CCR6 polymorphisms with susceptibility to Behcet's disease in two Chinese Han populations. (21873313)
2011
27
TIRAP Ser180Leu polymorphism is associated with Behcet's disease. (21705416)
2011
28
IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population. (20375120)
2010
29
Aortitis with severe aortic regurgitation in Behcet's disease: a case report. (20123590)
2010
30
Significance of serum interleukin-8 levels in patients with Behcet's disease: high levels may indicate vascular involvement. (19261013)
2009
31
A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. (19614861)
2009
32
Sister cases of Behcet's disease and Vogt-Koyanagi-Harada disease. (18303174)
2008
33
T cell large granular lymphocyte (LGL) leukemia associated with Behcet's disease: high expression of sFasL and IL-18 of CD8 LGL. (18236044)
2008
34
Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. (17343851)
2007
35
Selective anterograde amnesia with thalamus and hippocampal lesions in neuro-Behcet's disease. (17412491)
2007
36
LPS-stimulated production of TNF-alpha by peripheral blood monocytes in patients with Behcet's disease. (16897113)
2007
37
Efficacy and safety of interferon-alpha in the treatment of corticodependent uveitis of paediatric Behcet's disease. (17702770)
2007
38
Budd-Chiari syndrome in the course of Behcet's disease: clinical and laboratory analysis of four cases. (17369069)
2007
39
The assessment of oral health-related quality of life by factor analysis in patients with Behcet's disease and recurrent aphthous stomatitis. (17305636)
2007
40
Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD. (17343257)
2006
41
A case of Behcet's disease with scleromalacia perforans. (15840606)
2005
42
Are erythema nodosum-like lesions and superficial thrombophlebitis prodromal in terms of visceral involvement in Behcet's disease? (15707468)
2005
43
Superior vena cava syndrome: a rare clinical manifestation of Behcet's disease. (15349796)
2005
44
Constitutional trisomy 8 mosaicism with myelodysplastic syndrome complicated by intestinal Behcet disease and antithrombin III deficiency. (16213367)
2005
45
HLA class I and class II genotyping in patients with Behcet's disease: a regional study of eastern part of Turkey. (15304011)
2004
46
Influence of human recombinant interferon-alpha2a (rhIFN-alpha2a) on altered lymphocyte subpopulations and monocytes in Behcet's disease. (15252211)
2004
47
Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease. (15196263)
2004
48
The absence of disease-specific polymorphisms within the HLA-B51 gene that is the susceptible locus for Behcet's disease. (11696219)
2001
49
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
50
Behcet's disease presenting as chronic aphthous stomatitis in a child. (693157)
1978

Genetic Variations for Behcet's Disease

Expression for genes affiliated with Behcet's Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Behcet's Disease

Search GEO for disease gene expression data for Behcet's Disease.

Pathways for genes affiliated with Behcet's Disease

Sources:
30KEGG, 52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore
See all sources

Pathways related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0NOD2, CCR5, TLR4, STAT4, IL12RB2, IL10
2
Hide members
11.0CCR5, TLR4, STAT4, LTA, IL12RB2, IL10
3
Hide members
10.9TLR4, MBL2, CTLA4, HLA-B, MEFV, MICB
4
Hide members
10.9CCR5, STAT4, LTA, IL12RB2, IL10, IL18
5
Hide members
10.9TLR4, STAT4, LTA, IL12RB2, IL10, IL18
6
Hide members
10.9CTLA4, HLA-B, LTA, IL12RB2, IL10, IL18
7
Hide members
10.8STAT4, LTA, IL12RB2, IL10, IL18
810.7STAT4, IL12RB2, IL10, IL23R
9
Hide members
10.7CCR5, TLR4, IL12RB2, IL23R
10
Development PDGF signaling via STATs and NF-kB
Hide members
10.7STAT4, IL10, IL18, IL23R
1110.7TLR4, IL10, IL18, NOD2
12
Hide members
10.7HLA-B, MICB, KIR2DL1, KIR3DL1
13
Hide members
10.7IL18, LTA, HLA-B, TLR4
14
Hide members
10.7IL23R, IL12RB2, LTA, CCR5
15
Hide members
10.7IL18, IL12RB2, STAT4, CCR5
16
Hide members
10.7MEFV, IL18, NOD2
17
Hide members
10.7KIR3DL1, KIR2DL1, MICB
1810.7IL18, CTLA4, TLR4
1910.7LTA, IL10, IL18
20
Hide members
10.6STAT4, IL23R
2110.6IL18, TLR4

Compounds for genes affiliated with Behcet's Disease

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Behcet's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.7IL12RB2, IL18, KIR2DL1, CTLA4, KIR3DL1, LTA
2nitric oxide45 11 2413.5IL18, IL10, RBP3, HLA-B, NAT2, TLR4
3lipid4511.4KIR3DL1, MBL2, SAG, TLR4, HLA-B, LTA
4cholesterol45 29 11 2414.4HLA-B, NAT2, TLR4, CTLA4, MBL2, LTA
5il 104511.4CCR5, NOD2, TLR4, CTLA4, LTA, IL18
6serine4511.3LTA, IL18, CTLA4, TLR4, CCR5, NOD2
7lipoteichoic acid4511.3IL18, IL10, LTA, HLA-B, MBL2, TLR4
8infliximab45 50 1113.3NOD2, IL18, TLR4, IL10, LTA, CTLA4
9zinc45 2412.2IL18, KIR3DL1, RBP3, HLA-B, MBL2, TLR4
10vitamin d4511.2MBL2, CCR5, TLR4, CTLA4, LTA, IL10
11ribavirin45 50 1113.2IL18, CCR5, MBL2, IL10, HLA-B
12allergens4511.2TLR4, STAT4, CTLA4, IL10, IL18
13latex4511.2IL18, MBL2, TLR4, HLA-B, CCR5
14prednisolone45 29 1113.2MBL2, LTA, NOD2, IL18, IL10
15tgf beta14511.2IL18, TLR4, CTLA4, LTA, IL10
16rantes4511.2TLR4, MBL2, HLA-B, LTA
17mannose4511.2LTA, NOD2, MBL2, TLR4, CCR5
18dexamethasone45 50 29 1114.2NAT2, LTA, CTLA4, TLR4
19cyclosporin a45 29 6013.2HLA-B, LTA, CTLA4, SAG
20polyinosinic-polycytidylic acid4511.1IL10, HLA-B, TLR4, IL18
21con a4511.1CTLA4, IL10, IL18, MBL2
22aspartate4511.1HLA-B, MBL2, SAG, CCR5
23peptidoglycan45 2912.1IL10, NOD2, MBL2, TLR4
24steroid4511.1CTLA4, HLA-B, IL18, LTA, SAG, MBL2
25isoleucine4511.1KIR3DL1, MEFV, CCR5, NAT2
26polysaccharide4511.1IL18, MBL2, TLR4, CCR5, HLA-B
27ivig4511.1CCR5, IL10, LTA, SAG
28ccl345 2912.1CCR5, TLR4, IL10, IL18
29neopterin4511.1MBL2, IL18, IL10, LTA
30thalidomide45 50 60 1114.1IL18, NAT2, CTLA4, IL10
31calcium45 50 11 2414.0NOD2, LTA, HLA-B, CTLA4, MBL2, SAG
32paraffin4511.0IL10, LTA, SAG, MBL2, HLA-B
33tuberculin4511.0MBL2, IL18, IL10
34simvastatin45 50 60 29 11 2416.0CCR5, TLR4, IL10, IL18
35il-124511.0IL18, IL10, STAT4
36endotoxin4511.0MEFV
37imiquimod45 29 60 1114.0TLR4, IL10, IL18
38pge24511.0SAG
39polymyxin b4511.0TLR4, MBL2, IL10
40groalpha4510.9IL10, IL18, CCR5
41ionomycin4510.9CTLA4, LTA, IL10, IL18
42tacrolimus45 50 1112.9CTLA4
43etanercept45 50 1112.9IL18, LTA, IL10
442,5-oligoadenylate4510.8TLR4, HLA-B
45mycophenolate mofetil45 50 1112.8IL18, IL10, CTLA4
46cimetidine45 29 1112.7HLA-B, IL10, IL18
47methotrexate45 50 1112.7CTLA4, NAT2, IL10, IL18
48diaminopimelic acid4510.7NOD2, TLR4
49tarc4510.6IL18, IL10, CCR5
50vitamin a45 11 2412.4NAT2, RBP3, SAG

GO Terms for genes affiliated with Behcet's Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Behcet's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7IL12RB2, CTLA4, TLR4, CCR5
2integral to plasma membraneGO:00588710.6KIR3DL1, CCR5, TLR4, CTLA4, HLA-B, IL12RB2

Biological processes related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.3CCR5, CTLA4, TLR4, HLA-B, IL18, KIR2DL1
2positive regulation of interferon-gamma productionGO:03272911.2IL23R, IL12RB2, IL18, TLR4, LTA
3response to lipopolysaccharideGO:03249611.2NOD2, LTA, IL12RB2, IL23R, TLR4
4inflammatory responseGO:00695411.1IL23R, MEFV, IL18, IL10, CCR5
5negative regulation of growth of symbiont in hostGO:04413011.1NOD2, IL10, LTA, MBL2
6regulation of immune responseGO:05077611.1KIR3DL1, KIR2DL1, MICB, HLA-B
7defense response to bacteriumGO:04274211.1NOD2, MBL2, TLR4, IL10
8positive regulation of interleukin-17 productionGO:03274011.0IL18, NOD2, IL23R
9negative regulation of interleukin-12 productionGO:03269511.0MEFV, NOD2, IL10
10positive regulation of interleukin-12 productionGO:03273511.0NOD2, TLR4, IL23R
11negative regulation of interferon-gamma productionGO:03268911.0TLR4, IL10, NOD2
12negative regulation of tumor necrosis factor productionGO:03272011.0IL10, NOD2, TLR4
13positive regulation of tumor necrosis factor productionGO:03276011.0TLR4, IL18, NOD2
14defense response to Gram-positive bacteriumGO:05083011.0MBL2, LTA, NOD2
15type 2 immune responseGO:04209210.9IL10, IL18
16positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.9IL23R, IL18
17cellular response to lipopolysaccharideGO:07122210.9IL10, TLR4, CCR5
18positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.9LTA, NOD2
19positive regulation of natural killer cell proliferationGO:03281910.8IL23R, IL18
20cell-cell signalingGO:00726710.8LTA, IL10, IL18, CCR5
21positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, TLR4
22interferon-gamma productionGO:03260910.8IL12RB2, TLR4
23positive regulation of interleukin-1 beta productionGO:03273110.8NOD2, IL18
24positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.7NOD2, TLR4
25detection of bacteriumGO:01604510.6NOD2, HLA-B
26negative regulation of B cell proliferationGO:03088910.6IL10, CTLA4
27T-helper 1 type immune responseGO:04208810.5IL18, TLR4
28innate immune responseGO:04508710.5MBL2, HLA-B, MEFV, NOD2, TLR4

Products for genes affiliated with Behcet's Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Behcet's Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet