BD
MCID: BHC002
MIFTS: 76

Behcet's Disease (BD) malady

Neuronal diseases, Eye diseases, Nephrological diseases, Bone diseases, Skin diseases categories

Summaries for Behcet's Disease

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 46OMIM, 32MalaCards
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MedlinePlus:33 Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. most people can control symptoms with treatment. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Behcet's Disease, also known as behcet syndrome, is related to vasculitis and multiple sclerosis, and has symptoms including mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly, paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness and renal glomerular defect/glomerulopathy. An important gene associated with Behcet's Disease is MEFV (Mediterranean fever), and among its related pathways are Leishmaniasis and Akt Signaling. The drug thalidomide and the compounds tyrosine and lipid have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and bone, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

Genetics Home Reference:21 Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.

NIH Rare Diseases:42 Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. the disease is common in japan, turkey and israel, and less common in the united states. the exact cause of behcet's disease is unknown.  treatment is symptomatic and supportive. last updated: 12/4/2009

NINDS:43 Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and

Description from OMIM:46 109650

Aliases & Classifications for Behcet's Disease

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 44Novoseek, 48Orphanet, 46OMIM, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:



Characteristics (Orphanet epidemiological data):

48
behçet disease:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Adult


Aliases & Descriptions:

behcet's disease 8 42 43 30
behcet syndrome 8 42 21 60
behcet's syndrome 42 21 33
behçet disease 21 48 46
behcet disease 42 21 44
adamantiades-behcet disease 8 21
triple symptom complex 8 21
behcet triple symptom complex 21
old silk route disease 21
behet's syndrome 8
bd 42


External Ids:

Disease Ontology8 DOID:13241
MeSH34 D001528
OMIM46 109650
ICD9CM27 136.1
NCIt39 C34416
MESH via Orphanet35 D001528
ICD10 via Orphanet26 M35.2
SNOMED-CT via Orphanet57 310701003
UMLS via Orphanet61 C0004943

Related Diseases for Behcet's Disease

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Behcet's Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.1SAG, MBL2, CTLA4, HLA-B, MEFV, RBP3
2multiple sclerosis30.1IL18, IL10, LTA, STAT4, HLA-B, CTLA4
3encephalomyelitis30.1CCR5, CTLA4, IL10, LTA, STAT4
4glomerulonephritis29.9CCR5, MBL2
5atherosclerosis29.9MBL2, STAT4, IL10, IL18, NOD2, CCR5
6retinitis29.9SAG
7aphthous stomatitis29.9HLA-B
8meningitis29.9HLA-B, MBL2
9encephalitis29.9HLA-B, CCR5
10influenza29.9MBL2, CCR5, LTA, HLA-B
11adenocarcinoma29.9CCR5, HLA-B
12familial mediterranean fever29.9NOD2, MEFV
13tuberculosis29.9SAG, TLR4, IL10, IL18, NOD2, MBL2
14vascular disease29.8IL10
15binswanger's disease10.3
16dementia - subcortical10.3
17subcortical arteriosclerotic encephalopathy10.3
18diamond-blackfan anemia10.2
19bipolar disorder10.2
20cervicitis10.2
21myelitis10.1
22ulcerative stomatitis10.1
23rheumatoid arthritis10.0CCR5, TLR4, MBL2, CTLA4, STAT4, MEFV
24viral infectious disease10.0IL10, IL18, KIR3DL1, TLR4, CCR5, MBL2
25melanoma10.0HLA-B, CTLA4, KIR2DL1, SAG, TLR4, KIR3DL1
26arthritis10.0CTLA4, CCR5, TLR4, LTA, MEFV, HLA-B
27uveitis10.0CCR5, SAG, CTLA4, RBP3, LTA, IL10
28graves' disease10.0LTA, CTLA4, CCR5, HLA-B
29leukemia10.0MBL2, TLR4, HLA-B, LTA, KIR3DL1
30hepatitis10.0LTA, IL18, CTLA4, HLA-B
31asthma10.0STAT4, IL10, IL18, HLA-B, CTLA4, TLR4
32psoriasis10.0NOD2, KIR3DL1, CTLA4, HLA-B, LTA, IL10
33immunodeficiency with hyper igm type 210.0TLR4, LTA, KIR3DL1, HLA-B, CCR5
34sarcoidosis10.0LTA, IL12RB2, IL18, CCR5, NOD2
35primary biliary cirrhosis10.0MBL2, CTLA4, HLA-B, LTA
36graft versus host disease10.0IL18, IL10, LTA, CTLA4, KIR3DL1, CCR5
37coronary heart disease10.0TLR4, CCR5, IL18, LTA
38celiac disease10.0MICB, CTLA4
39polymyositis10.0CCR5, CTLA4, HLA-B
40adenoma10.0HLA-B, SAG, CTLA4, TLR4
41dermatitis10.0CTLA4, IL18, NOD2
42myeloma10.0HLA-B, LTA
43wegener's granulomatosis10.0CCR5, CTLA4
44diabetes mellitus10.0HLA-B, CTLA4
45myeloid leukemia10.0KIR3DL1, LTA, TLR4
46vitiligo10.0CTLA4, HLA-B
47myasthenia gravis10.0IL10, LTA, HLA-B, CTLA4, CCR5
48lupus nephritis10.0IL18, IL10, MBL2, CCR5, LTA
49pulmonary sarcoidosis10.0LTA, IL18, CCR5
50atopy10.0NOD2, IL18, IL10, IL12RB2, LTA, CTLA4

Graphical network of the top 20 diseases related to Behcet's Disease:



Diseases related to behcet's disease

Clinical Features for Behcet's Disease

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

109650

Clinical synopsis from OMIM:

109650

Symptoms:

48 (show all 67)
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • renal glomerular defect/glomerulopathy
  • dizziness
  • pulmonary thromboembolism
  • anorexia
  • pancreatitis
  • transient cerebral ischemia/stroke
  • facial pain/cephalalgia/migraine
  • venous thrombosis/phlebitis/thrombophlebitis
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • troubles of memory/amnesia/hypermnesia
  • endocardium anomalies/fibroelastosis/endocarditis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • vascularitis/vasculitides/arteritis
  • cataract/lens opacification
  • testes inflammation/orchitis
  • retrobulbar optic neuritis
  • severe allergic reaction/atopy
  • xerophthalmia/dry eyes
  • neuritis/polyneuritis/multineuritis
  • intestinal perforation
  • lymphadenopathy/polyadenopathies
  • hemoptysis
  • arterial embolism/thrombosis
  • meningitis/meningeal syndrome
  • enanthema/aphtosa/aphta/leukoplakia
  • myocardium anomalies/myocarditis
  • psychic/behavioural troubles
  • cranial hypertension
  • osteonecrosis/bone infarction
  • arthritis/synovitis/synovial proliferation
  • malabsorption/chronic diarrhea/steatorrhea
  • obnubilation/coma/lethargia/desorientation
  • visual loss/blindness/amblyopia
  • photophobia
  • splenomegaly
  • early death/lethality
  • pyramidal syndrome
  • hypereflexia
  • seizures/epilepsy/absences/spasms/status epilepticus
  • abnormal gait
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • encephalitis
  • psychic/psychomotor regression/dementia/intellectual decline
  • asthenia/fatigue/weakness
  • retinopathy
  • gangrena/necrosis
  • myalgia/muscular pain
  • acute abdominal pain/colic
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • angor pectoris/myocardial infarction
  • myositis
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • lung/pulmonary infiltrates
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • acne/acnea
  • renal failure
  • cranial nerves palsy
  • fever/chilling
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • follicular/erythematous/edematous papules/milium
  • vesicles/bullous/exsudative lesions/bullous/cutaneous/mucosal detachment
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Behcet's Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Behcet's Disease

Drug clinical trials:

Search ClinicalTrials for Behcet's Disease

Search NIH Clinical Center for Behcet's Disease

Search CenterWatch for Behcet's Disease

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Behcet's Disease cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Behcet's Disease:
Bone marrow-derived stem cells for treatment of ocular lesions Behcet's disease
Embryonic/Adult Cultured Cells Related to Behcet's Disease:
Bone marrow-derived stem cells, PMIDs: 21199472, 23773637

Genetic Tests for Behcet's Disease

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Anatomical Context for Behcet's Disease

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32MalaCards
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MalaCards organs/tissues related to Behcet's Disease:

32
Eye, Skin, Bone, Testes, T cells, Lung, Monocytes, Brain, Thalamus, Whole blood, Colon, Endothelial, Myeloid, Heart

Animal Models for Behcet's Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Behcet's Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5NOD2, CCR5, TLR4, MBL2, CTLA4, HLA-B
2MP:000538711.4HLA-B, CTLA4, MBL2, TLR4, CCR5, STAT4
3MP:000538411.3STAT4, HLA-B, CTLA4, TLR4, CCR5, MEFV
4MP:000537611.2STAT4, CTLA4, MBL2, TLR4, CCR5, MEFV
5MP:000537010.8CCR5, TLR4, CTLA4, MEFV, LTA, IL12RB2
6MP:000539110.7RBP3, SAG, TLR4
7MP:000538110.6CCR5, TLR4, CTLA4, IL12RB2, IL10, IL18

Publications for Behcet's Disease

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Sources:
50PubMed
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Articles related to Behcet's Disease:

(show top 50)    (show all 285)
idTitleAuthorsYear
1
Is there a relation between clinical disease activity and acute phase response in Behcet's disease? (24261602)
2014
2
Pro-inflammatory cytokine and caspase-1 responses to pattern recognition receptor activation of neutrophils and dendritic cells in Behcet's disease. (23325038)
2013
3
Does Behcet's disease associate with neuropathic pain syndrome and impaired well-being? (23001467)
2013
4
Behcet's disease seen in China: analysis of 334 cases. (22527133)
2013
5
Could increased IgA induced by BAFF be the cause of IgA nephropathy development in Behcet's disease? : Comment on: Behcet's disease and IgA nephropathy (Rheumatol Int. 2012 Jul; 32(7):2227-9). (23334375)
2013
6
Methotrexate in ocular manifestations of Behcet's disease: a longitudinal study up to 15 years. (24164845)
2013
7
Higher expression of Toll-like receptors 2, 3, 4, and 8 in ocular Behcet's disease. (23908180)
2013
8
Behcet's disease: systemic and ocular manifestations. (24199188)
2013
9
Clinical course of intestinal Behcet's disease during the first five years. (22899244)
2013
10
Successful Treatment of Vasculo-Behcet's Disease Presenting as Recurrent Pseudoaneurysms: the Importance of Medical Treatment. (23888260)
2013
11
Recurrent aortic aneurysm due to Behcet's disease: a case report from China. (22971707)
2013
12
Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia. (24322831)
2013
13
Serum level of interleukin-33 and soluble ST2 and their association with disease activity in patients with Behcet's disease. (23960440)
2013
14
Peripheral arterial involvement in Behcet's disease: an analysis of the results from a Korean referral center. (23417141)
2013
15
CTLA-4 polymorphisms and susceptibility to Behcet's disease: a meta-analysis. (22722994)
2012
16
Bilateral Knee Pain Associated with Bone Infarction in a Patient with Behcet's Disease. (23198245)
2012
17
No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. (22396730)
2012
18
Tocilizumab treatment for neuro-Behcet's disease, the first report. (22078418)
2012
19
Behcet's disease and focal segmental glomerulosclerosis: an unusual association. (21833522)
2012
20
Behcet's disease with superior vena cava syndrome related to pacemaker leads: a case report. (22600024)
2012
21
Subpopulations of regulatory T cells in rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease. (22969245)
2012
22
Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease. (23155319)
2012
23
Cerebral abscesses in Behcet's disease: a case report. (22274984)
2012
24
Streptococcal hypersensitivity reloaded: severe inflammatory syndrome in Behcet's disease following 23-valent polysaccharide Streptococcus pneumoniae vaccine. (22157598)
2012
25
eComment. Behcet's disease or Adamantiades-Behcet's disease? (22354911)
2012
26
Salivary levels of antimicrobial peptides Hnp 1-3, Ll-37 and S100 in Behcet's disease. (22153317)
2012
27
Association of the toll-like receptor 9 gene polymorphisms with Behcet's disease in a Japanese population. (23237868)
2012
28
Behcet's disease with active uveitis: detection of serum protein biomarkers using MALDI-TOF-MS. (22641412)
2012
29
Anti-cardiolipin and anti-Neutrophil Cytoplasmic Antibodies in Iranian patients with Behcet's disease. (23268290)
2012
30
Associations between the HLA-A polymorphism and the clinical manifestations of Behcet's disease. (21429233)
2011
31
Tibial neuropathy associated with Behcet's disease. (20881584)
2011
32
TIRAP Ser180Leu polymorphism is associated with Behcet's disease. (21705416)
2011
33
Endocardial fibroelastosis of the right ventricle and tricuspid valve in a young adult with Behcet's disease. (20202032)
2010
34
Pulmonary alveolar proteinosis in a patient with Behcet's disease. (19210651)
2009
35
Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. (18408113)
2008
36
Two cases of SAPHO syndrome accompanied by classic features of Behcet's disease and review of the literature. (17717714)
2008
37
Proteomic surveillance of autoimmunity in Behcet's disease with uveitis: selenium binding protein is a novel autoantigen in Behcet's disease. (17343851)
2007
38
Cytochrome P450 polymorphisms in patients with Behcet's disease. (17269966)
2007
39
Common FMF alleles may predispose to development of Behcet's disease with increased risk for venous thrombosis. (17454935)
2007
40
No association of KIR genes with Behcet's disease. (17868255)
2007
41
Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. (16809408)
2006
42
Evaluation of the association between null genotypes of glutathione-S-transferases and Behcet's disease. (16283344)
2006
43
Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. (15654837)
2005
44
Are erythema nodosum-like lesions and superficial thrombophlebitis prodromal in terms of visceral involvement in Behcet's disease? (15707468)
2005
45
Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease. (15654836)
2005
46
Plasma and whole-blood chemokine levels in patients with Behcet's disease. (12712358)
2003
47
Disturbed expression of Fas/FasL on CD4(+) and CD8(+)T cells in Behcet's disease, Vogt-Koyanagi-Harada syndrome, and idiopathic anterior uveitis. (11815887)
2001
48
The absence of disease-specific polymorphisms within the HLA-B51 gene that is the susceptible locus for Behcet's disease. (11696219)
2001
49
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
50
Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behcet's disease. (9174150)
1997

Genetic Variations for Behcet's Disease

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Expression for genes affiliated with Behcet's Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Behcet's Disease

Search GEO for disease gene expression data for Behcet's Disease.

Pathways for genes affiliated with Behcet's Disease

About this section
Sources:
29KEGG, 51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore
See all sources

Pathways related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0NOD2, CCR5, TLR4, STAT4, IL12RB2, IL10
2
Hide members
11.0CCR5, TLR4, STAT4, LTA, IL12RB2, IL10
3
Hide members
11.0TLR4, MBL2, CTLA4, C4A, HLA-B, MEFV
4
Hide members
10.9CCR5, STAT4, LTA, IL12RB2, IL10, IL18
5
Hide members
10.9TLR4, STAT4, LTA, IL12RB2, IL10, IL18
6
Hide members
10.9CTLA4, HLA-B, LTA, IL12RB2, IL10, IL18
7
Hide members
10.8STAT4, LTA, IL12RB2, IL10, IL18
810.7IL23R, IL10, IL12RB2, STAT4
9
Hide members
10.7CCR5, TLR4, IL12RB2, IL23R
10
Development PDGF signaling via STATs and NF-kB
Hide members
10.7IL23R, IL18, IL10, STAT4
1110.7TLR4, IL10, IL18, NOD2
12
Hide members
10.7KIR3DL1, KIR2DL1, MICB, HLA-B
13
Hide members
10.7TLR4, HLA-B, LTA, IL18
14
Hide members
10.7CCR5, LTA, IL12RB2, IL23R
15
Hide members
10.7IL18, IL12RB2, STAT4, CCR5
1610.7TLR4, C4A, IL10
17
Hide members
10.7MEFV, IL18, NOD2
18
Hide members
10.7HLA-B, C4A, MBL2
19
Hide members
10.7KIR3DL1, KIR2DL1, MICB
2010.7IL18, CTLA4, TLR4
2110.7IL10, C4A, MBL2
2210.7LTA, IL10, IL18
23
Hide members
10.6IL23R, STAT4
2410.6IL18, TLR4

Compounds for genes affiliated with Behcet's Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Behcet's Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.7CCR5, TLR4, SAG, MBL2, CTLA4, HLA-B
2lipid4411.4TLR4, SAG, MBL2, CTLA4, HLA-B, LTA
3nitric oxide44 11 2413.4TLR4, MBL2, HLA-B, RBP3, LTA, IL10
4il 104411.4NOD2, IL18, IL10, LTA, CTLA4, TLR4
5serine4411.3CCR5, TLR4, CTLA4, HLA-B, LTA, IL18
6lipoteichoic acid4411.3IL18, IL10, LTA, HLA-B, MBL2, TLR4
7infliximab44 49 1113.3TLR4, CTLA4, LTA, IL10, IL18, NOD2
8cholesterol44 28 11 2414.3IL18, LTA, HLA-B, CTLA4, MBL2, TLR4
9steroid4411.3SAG, MBL2, CTLA4, C4A, HLA-B, LTA
10zinc44 2412.3CCR5, TLR4, MBL2, HLA-B, RBP3, IL18
11vitamin d4411.3CCR5, TLR4, MBL2, CTLA4, LTA, IL10
12ribavirin44 49 1113.2CCR5, MBL2, HLA-B, IL10, IL18
13allergens4411.2TLR4, CTLA4, STAT4, IL10, IL18
14latex4411.2CCR5, TLR4, MBL2, HLA-B, IL18
15prednisolone44 28 1113.2MBL2, LTA, IL10, IL18, NOD2
16tgf beta14411.2TLR4, CTLA4, LTA, IL10, IL18
17mannose4411.2CCR5, TLR4, MBL2, LTA, NOD2
18rantes4411.2TLR4, MBL2, HLA-B, LTA
19cyclosporin a44 28 5913.2SAG, CTLA4, HLA-B, LTA
20con a4411.1IL18, IL10, CTLA4, MBL2
21polyinosinic-polycytidylic acid4411.1TLR4, HLA-B, IL10, IL18
22aspartate4411.1CCR5, SAG, MBL2, HLA-B
23peptidoglycan44 2812.1NOD2, IL10, MBL2, TLR4
24calcium44 49 11 2414.1CCR5, TLR4, SAG, MBL2, CTLA4, HLA-B
25polysaccharide4411.1IL18, HLA-B, MBL2, TLR4, CCR5
26ivig4411.1CCR5, SAG, LTA, IL10
27ccl344 2812.1IL18, IL10, TLR4, CCR5
28dexamethasone44 49 28 1114.1LTA, CTLA4, TLR4
29neopterin4411.1MBL2, LTA, IL10, IL18
30endotoxin4411.1C4A, MEFV
31paraffin4411.0SAG, MBL2, HLA-B, LTA, IL10
32tuberculin4411.0IL18, IL10, MBL2
33simvastatin44 49 59 28 11 2416.0CCR5, TLR4, IL10, IL18
34il-124411.0IL18, IL10, STAT4
35imiquimod44 28 59 1114.0TLR4, IL10, IL18
36polymyxin b4411.0TLR4, MBL2, IL10
37pge24411.0SAG
38oxygen44 2412.0C4A, MBL2, SAG
39groalpha4410.9IL18, IL10, CCR5
40ionomycin4410.9CTLA4, LTA, IL10, IL18
41tacrolimus44 49 1112.9CTLA4
42etanercept44 49 1112.9IL18, IL10, LTA
432,5-oligoadenylate4410.9HLA-B, TLR4
44mycophenolate mofetil44 49 1112.8IL18, IL10, CTLA4
45cimetidine44 28 1112.8IL18, IL10, HLA-B
46diaminopimelic acid4410.8TLR4, NOD2
47threonine4410.8CCR5, SAG, CTLA4, C4A, LTA, NOD2
48tarc4410.7CCR5, IL10, IL18
49pentoxifylline44 1111.7IL18, IL10, LTA
50isoleucine4410.4KIR3DL1, MEFV, CCR5

GO Terms for genes affiliated with Behcet's Disease

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16Gene Ontology
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Cellular components related to Behcet's Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9IL18, IL10, LTA, RBP3, C4A, MBL2
2integral to plasma membraneGO:00588710.8KIR3DL1, KIR2DL1, IL12RB2, HLA-B, CTLA4, TLR4
3external side of plasma membraneGO:00989710.4CCR5, TLR4, CTLA4, IL12RB2

Biological processes related to Behcet's Disease according to GeneCards/GeneDecks:

(show all 28)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.3CCR5, TLR4, CTLA4, HLA-B, IL18, KIR2DL1
2inflammatory responseGO:00695411.2CCR5, C4A, MEFV, IL10, IL18, IL23R
3positive regulation of interferon-gamma productionGO:03272911.2IL23R, IL18, IL12RB2, LTA, TLR4
4response to lipopolysaccharideGO:03249611.2TLR4, LTA, IL12RB2, IL23R, NOD2
5innate immune responseGO:04508711.1TLR4, MBL2, C4A, HLA-B, MEFV, NOD2
6negative regulation of growth of symbiont in hostGO:04413011.1MBL2, LTA, IL10, NOD2
7regulation of immune responseGO:05077611.1HLA-B, MICB, KIR2DL1, KIR3DL1
8defense response to bacteriumGO:04274211.1TLR4, MBL2, IL10, NOD2
9positive regulation of interleukin-17 productionGO:03274011.0IL18, IL23R, NOD2
10negative regulation of interleukin-12 productionGO:03269511.0NOD2, IL10, MEFV
11positive regulation of interleukin-12 productionGO:03273511.0NOD2, IL23R, TLR4
12negative regulation of interferon-gamma productionGO:03268911.0TLR4, IL10, NOD2
13negative regulation of tumor necrosis factor productionGO:03272011.0NOD2, IL10, TLR4
14positive regulation of tumor necrosis factor productionGO:03276011.0TLR4, IL18, NOD2
15defense response to Gram-positive bacteriumGO:05083011.0NOD2, LTA, MBL2
16type 2 immune responseGO:04209210.9IL18, IL10
17positive regulation of natural killer cell proliferationGO:03281910.9IL18, IL23R
18cellular response to lipopolysaccharideGO:07122210.8CCR5, TLR4, IL10
19positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.8IL18, IL23R
20positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, NOD2
21positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, TLR4
22cell-cell signalingGO:00726710.8CCR5, LTA, IL10, IL18
23interferon-gamma productionGO:03260910.8IL12RB2, TLR4
24positive regulation of interleukin-1 beta productionGO:03273110.7NOD2, IL18
25positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.6NOD2, TLR4
26detection of bacteriumGO:01604510.6NOD2, HLA-B
27T-helper 1 type immune responseGO:04208810.5TLR4, IL18
28negative regulation of B cell proliferationGO:03088910.3CTLA4, IL10

Products for genes affiliated with Behcet's Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet