Behcet's Disease malady

MedlinePlus: Behcet's syndrome is a disease that involves inflammation of the blood vessels. it causes problems in many parts of the body. the most common symptoms are sores in the mouth sores on the sex organs other skin sores swelling of parts of the eye pain, swelling and stiffness of the joints more serious problems can include meningitis, blood clots, inflammation of the digestive system and blindness. doctors aren't sure what causes behcet's. it is rare in the united states, but is common in the middle east and asia. it mainly affects people in their 20s and 30s. diagnosing behcet's can take a long time, because symptoms may come and go, and it may take months or even years to have all of the symptoms. there is no cure. treatment focuses on reducing pain and preventing serious problems. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Behcet's Disease, also known as behcet's syndrome, is related to familial mediterranean fever and ankylosing spondylitis. An important gene associated with Behcet's Disease is C9orf174 (chromosome 9 open reading frame 174), and among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response_Role of DAP12 receptors in NK cells. The drug thalidomide and the compounds ivig and nadph have been mentioned in the context of this disorder. Affiliated tissues include whole blood, skin and myeloid, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Disease Ontology: An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.⁶

NIH Rare Diseases: Behcet's disease is a chronic multisystem inflammatory disorder characterized by ulcers affecting the mouth and genitals, various skin lesions, and abnormalities affecting the eyes. Although it can happen at any age, symptoms generally begin when individuals are in their 20s or 30s. The disease is common in Japan, Turkey and Israel, and less common in the United States. The exact cause of Behcet's disease is unknown.  Treatment is symptomatic and supportive.³⁰

NINDS: Behcet's disease is a rare, chronic inflammatory disorder. The cause of Behcet's disease is unknown, but current research suggests that both genetic and ³¹

Genetics Home Reference: Behçet disease is an inflammatory condition that affects many parts of the body. The health problems associated with Behçet disease result from widespread inflammation of blood vessels (vasculitis). This inflammation most commonly affects the mouth, genitals, skin, and eyes.¹⁷

Aliases & Descriptions:

behcet's disease 6 30 31 behcet's syndrome 30 17 23 behcet syndrome 6 30 43 adamantiades-behcet disease 6 17 triple symptom complex 6 17 behcet disease 30 32

behet's syndrome (disorder) 6 old silk route disease 17 behçet disease 17 behcets disease 8 bd 30

Diseases related to behcet's disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 968)

id	Related Disease	Score	Top Affiliating Genes
1	familial mediterranean fever	30.9	MEFV, TNF, TNFRSF1A, NLRP3
2	ankylosing spondylitis	30.8	IL17A, IL1RN, HSPD1, HLA-B, TNF, TNFRSF1A
3	periodic fever	30.4	MVK, SAA1, MEFV, IL1B, IL1RN, IFNG
4	deep vein thrombosis	30.2	VWF, SELP, SERPINC1, SERPINE1, MTHFR, APOH
5	retinal vasculitis	30.2	SAG, ARR3, APOH, CCL4, IFNA2, TNF
6	venous thrombosis	30.0	VWF, SELP, SERPINC1, SERPINE1, MTHFR, ITGB2
7	arthritis	29.8	SELL, IL17A, IL1A, IL1B, IL6, IL8
8	multiple sclerosis	29.7	MICB, MICA, IL1A, IL1B, IL1RN, IL2RA
9	antithrombin iii deficiency	29.6	SERPINC1, MTHFR, APOH, F5, F2
10	anterior uveitis	29.4	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR2DS4
11	myelodysplastic syndrome	29.2	KIR3DL1, SELL, MPO, CD69, IRF1, GSTM1
12	periodontitis	28.6	MPO, MMP9, FCGR3A, IL10, IL17A, IL1A
13	uveitis	28.1	KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1, KIR2DS4
14	aphthous stomatitis	28.1	MVK, CD69, MEFV, IL10, IL1A, IL1B
15	stomatitis	28.0	CD69, MICB, MICA, MEFV, IL10, IL1A
16	crohn's disease	27.5	MPO, IRF1, IL10, IL12B, IL17A, IL18
17	systemic lupus erythematosus	27.1	LRP2, VWF, SELE, NAT2, LBR, S100A8
18	connective tissue disease	27.1	VWF, SELE, SELL, S100A8, MPO, MICA
19	immunodeficiency	26.5	KIR3DL1, RBP3, SELL, SAG, CD28, CD69
20	amyloidosis	26.3	VWF, SERPINC1, LPA, SAA1, SAA4, MMP9
21	hyperhomocysteinemia	26.2	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
22	cholera	25.4	MPO, ITGB2, IL10, IL12B, IL17A, IL1A
23	homocysteine	25.3	VWF, SELE, SELP, SERPINC1, SERPINE1, NAT2
24	vasculitis	25.2	VWF, RBP3, SELE, SELL, SELP, SERPINC1
25	thrombosis	24.6	VWF, SELE, SELL, SELP, SERPINC1, SERPINE1
26	major depressive disorder	24.1	SELP, SERPINE1, VEGFA, LEP, MTHFR, MPO
27	spondylitis	23.2	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
28	insulin resistance	21.9	VWF, SELE, SELL, SELP, SERPINE1, VEGFA
29	retinitis	20.7	LRP2, VWF, RBP3, SELE, SELP, SERPINC1
30	lupus erythematosus	20.1	LRP2, KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR2DL4
31	cervicitis	19.1	KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3, KIR2DL4, KIR2DS4
32	leukemia	17.9	KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DL1, KIR2DL3
33	neuronitis	16.7	LRP2, KIR2DS4, VWF, SELE, SELP, SERPINC1
34	birdshot chorioretinopathy	14.4	KIR2DS3, KIR2DL1, KIR3DS1, KIR2DS4, KIR3DL1, KIR2DS2
35	primary biliary cirrhosis	14.2	SELL, LBR, MBL2, ENO1, F2, HSPG2
36	posterior uveitis	14.1	RBP3, SAG, IL2RA, FASLG, FAS, IFNA1
37	adult respiratory distress syndrome	14.1	SELE, IL8, TNF, THBD, CP
38	intermediate uveitis	14.1	IL2RA, CCR4, CCR5, CXCR3
39	allergic contact dermatitis of eyelid	14.1	SELE, NAT2, IL17A, CCR4, ICAM1, CXCR3
40	periodic fever, familial, autosomal dominant	14.0	MVK, MEFV, TNF, TNFRSF1A
41	acute interstitial pneumonia	14.0	CCR4, HSPG2, SRF, NOD2, THBD, CXCR3
42	chronic inflammatory demyelinating polyneuropathy	14.0	CD28, IFNA1, IFNA2, TNF, CTLA4, NGF
43	panniculitis	14.0	IL2RA, APOH, FAS, IFNG, TRD@, TRG@
44	amyloidosis, secondary	14.0	LPA, SAA1, SAA4, MEFV, APOA1, CRP
45	addison's disease	14.0	MICB, MICA, FCGR2A, FCGR3A, FCGR3B, CCR5
46	hyper-igd syndrome	14.0	MVK, SAA1, IL1RN, TNF, TNFRSF1A, CRP
47	spondylarthropathy	14.0	S100A8, CD163, TNF, CRP, TLR4
48	htlv-1 associated myelopathy	14.0	IL2, IL2RA, FASLG, FAS, CCL3, IFNA1
49	pityriasis rosea	14.0	IFNA2, HLA-A, HLA-B, HLA-C, HLA-DRB1
50	schnitzler syndrome	14.0	IL18, IL1A, IL1RN, TNF, CRP, NLRP3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 thalidomide

MalaCards organs/tissues related to behcet's disease:

²²

MGI Mouse Phenotypes related to behcet's disease:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	9.9	LRP2, SELP, UACA, APOE, TNFRSF1B, NOS3
2	no phenotypic analysis	MP:0003012	9.9	CCR5, HLA-C, TRG@, CYP1A1, SRF, KTN1
3	respiratory system phenotype	MP:0005388	9.8	LRP2, SELL, SELP, UACA, IL12B, IL17F
4	hematopoietic system phenotype	MP:0005397	9.6	TAP1, CXCR2, SOD2, SLC11A1, ADA, TLR9
5	endocrine/exocrine gland phenotype	MP:0005379	9.3	TLR2, LTA, CTLA4, IFNG, FASLG, IL2
6	integument phenotype	MP:0010771	8.8	SELP, LBR, XDH, UACA, KRT16, TLR2
7	nervous system phenotype	MP:0003631	8.5	TLR2, G3BP1, EDN1, LTA, NGF, TNFRSF1B
8	immune system phenotype	MP:0005387	8.5	VWF, F2, HSPG2, HLA-C, TXK, TRD@
9	digestive/alimentary phenotype	MP:0005381	8.2	LRP2, VWF, VEGFA, LGALS3, LEP, LBR
10	skeleton phenotype	MP:0005390	8.0	IL6, FAS, MAPK14, CALCA, TNFRSF1A, TNFRSF1B
11	liver/biliary system phenotype	MP:0005370	7.9	NLRP3, TLR2, TLR4, PROS1, SOD1, ADA
12	growth/size phenotype	MP:0005378	7.9	KRT16, NFKB1, NGF, NLRP3, NOS3, SRF
13	adipose tissue phenotype	MP:0005375	7.9	TNFRSF1A, TNFRSF1B, NOS2, NOS3, ACE, TLR2
14	normal phenotype	MP:0002873	7.5	NFKB1, NLRP3, CTLA4, SRF, CYP1A1, TRG@
15	mortality/aging	MP:0010768	6.5	SERPINC1, SERPINE1, VEGFA, LGALS3, LEP, LBR
16	reproductive system phenotype	MP:0005389	6.2	CCR5, IFNG, HSPD1, TNF, TNFRSF1A, NOS2
17	vision/eye phenotype	MP:0005391	5.9	IL6, CXCR2, SOD1, SOD2, CP, TGFB1
18	tumorigenesis	MP:0002006	5.7	SELL, SERPINE1, LEP, UACA, MMP2, MMP9
19	muscle phenotype	MP:0005369	5.3	NOS2, SRF, TNFRSF1B, TNFRSF1A, TNF, TRIM63
20	behavior/neurological phenotype	MP:0005386	5.1	NOS3, NOS2, SRF, TNFRSF1B, TNFRSF1A, TNF
21	homeostasis/metabolism phenotype	MP:0005376	4.8	APOH, TNFRSF1A, TNFRSF1B, TEC, PTPN22, DARC
22	cellular phenotype	MP:0005384	4.0	TLR4, TLR9, THBD, TGFB1, TGFBR1, TAP1
23	cardiovascular system phenotype	MP:0005385	3.4	CXCR3, SOD1, SOD2, PON1, CP, CXCR2

Articles related to behcet's disease:

(show top 50)    (show all 236)

id	Title	Authors	Year	Affiliating Genes
1	Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. (18411217)	Do J.E.... Lee E.S.	2008	TLR2, TLR4
2	Serum BAFF levels and skin mRNA expression in patients with Behcet's disease. (19026118)	Hamzaoui K.... Hamzaoui A.	2008	TNFSF13B, TNFRSF13C
3	IL-6 receptor, IL-8 receptor and TNF-alpha238 (G/A) polymorphisms are not associated with Behcet's disease in patients of German or Turkish origin. (19026125)	Storz K.... Kotter I.	2008	TNF, IL8, IL6R
4	Association of the toll-like receptor 4 gene polymorphisms with Behcet's disease. (18408113)	Meguro A.... Mizuki N.	2008	TLR4
5	Cytomegalovirus colitis in a patient with Behcet's disease receiving tumor necrosis factor alpha inhibitory treatment. (18473420)	Sari I.... Akkoc N.	2008	TNF, IFNG
6	Relationship between thiolactonase activity and hyperhomocysteinemia according to MTHFR gene polymorphism in Tunisian Behcet's disease patients. (18076365)	Koubaa N.... Hammami M.	2008	MTHFR
7	The functional role of nuclear factor kappa-kappaB1 -94 ins/del ATTG promotor gene polymorphism in Behcet's disease: an exploratory study. (18616724)	Yalcin B.... Alli N.	2008	NFKB1
8	Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behcet's disease. (17983454)	Kose O.... Fortune F.	2008	KRT16, KRT15
9	New insights of HLA class I association to Behcet's disease in Portuguese patients. (18627572)	Bettencourt A.... Silva B.M.	2008	HLA-C, HLA-B
10	Differential expression of toll-like receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. (17934735)	Yavuz S.... Direskeneli H.	2008	TLR1, TLR2, TLR6
11	Endothelial nitric oxide synthase gene polymorphism is associated with Behcet's disease in Tunisian population. (18718857)	Ben Dhifallah I.... Hamzaoui K.	2008	NOS3
12	Serum galectin-3 and galectin-3 binding protein levels in Behcet's disease and their association with disease activity. (17949550)	Lee Y.J.... Song Y.W.	2007	LGALS3, LGALS3BP, G3BP1
13	Efficacy and safety of interferon-alpha in the treatm ent of corticodependent uveitis of paediatric Behcet's disease. (17702770)	Guillaume-Czitrom S.... Kone-Paut I.	2007	IFNA2
14	Increased endothelin-1 levels of BAL fluid in patients with Behcet's disease. (17497041)	Hamzaoui K.... Hamzaoui A.	2007	EDN1
15	Serum MMP-2 and MMP-9 in patients with Behcet's disease: do their higher levels correlate to vasculo-Behcet's disease associated with aneurysm formation? (17949555)	Pay S.... Dinc A.	2007	MMP2, MMP9
16	Lack of association between leptin G2548A gene polymorphism and Behcet's disease. (17207170)	Aydin F.... Turanli A.Y.	2007	LEP
17	Tumor necrosis factor gene polymorphisms in Tunisian patients with Behcet's disease. (17349875)	Kamoun M.... Hamzaoui K.	2007	TNF, LTA
18	Intracellular cytokine patterns in Behcet's disease in comparison to ankylosing spondylitis--influence of treatment with interferon-alpha2a. (17949552)	Amberger M.... Kotter I.	2007	IL2
19	Lack of association of the -463 G/A myeloperoxidase promoter polymorphism with Behcet's disease in Italian patients. (17855424)	Atzeni F.... Salvarani C.	2007	MPO
20	Single nucleotide polymorphisms of Ficolin 2 gene in Behcet's disease. (16839748)	Chen X.... Mizuki N.	2006	FCN2
21	Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with Behcet's disease. (17067432)	Oksel F.... Doganavsargil E.	2006	NOS3
22	TNF-alpha gene 1031 T/C polymorphism in Turkish patients with Behcet's disease. (16882174)	Akman A.... Yegin O.	2006	TNF
23	Association of TNFA promoter region haplotype in Behcet's Disease. (16891799)	Park K.... Lee E.S.	2006	TNF
24	SLC11A1 gene polymorphisms in Korean patients with Behcet's disease. (17062442)	Kim S.K.... Chang H.K.	2006	SLC11A1
25	Fas (CD95) and bcl-2 expression in active skin lesions of Behcet's disease. (16164710)	Baris Y.S.... Kandemir B.	2005	FAS
26	CTLA-4 gene 49A/G polymorphism in Turkish patients with Behcet's disease. (16045690)	Sallakci N.... Yegin O.	2005	CTLA4
27	Serum interleukin 18 and tumour necrosis factor-alpha levels are increased in Behcet's disease. (15663506)	Oztas M.O.... Sancak B.	2005	TNF, IL18
28	Interleukin-18 gene polymorphisms in Korean patients with Behcet's disease. (16273766)	Jang W.C.... Chang H.K.	2005	IL18
29	Thrombin activatable fibrinolysis inhibitor in Behcet's disease. (15668188)	Donmez A.... Doganavsargil E.	2005	CPB2
30	Cytochrome P450 1A1 and manganese superoxide dismutase gene polymorphisms in Behcet's disease. (15088300)	Yen J.H.... Liu H.W.	2004	SOD2, CYP1A1
31	Class I and class II MHC polymorphisms in Mexican patients with Behcet's disease. (15158619)	Soto-Vega E.... Granados J.	2004	HLA-DRB1, HLA-B
32	The MCP-1 promoter -2518 polymorphism in Behcet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients. (15115316)	Cho M.L.... Hwang S.Y.	2004	CCL2
33	Vascular endothelial growth factor gene polymorphisms in Behcet's disease. (15338501)	Salvarani C.... Pulsatelli L.	2004	VEGFA
34	New insights into the pathogenesis and therapy of Behcet's disease. (15063364)	Arayssi T.... Hamdan A.	2004	HLA-B
35	Expression of KIR and C-type lectin receptors in Behcet's disease. (14679294)	Saruhan-Direskeneli G.... Gul A.	2004	KIR3DL1, KLRD1, CLEC4D
36	Association of transporter associated with antigen processing genes with Behcet's disease in Japanese. (12911283)	Takizawa K.... Yamamoto K.	2003	TAP1, HLA-B, TAP2
37	T-gammadelta receptor restriction in peripheral lymphocytes of patients with Behcet's disease. (12918704)	van Hagen P.M.... Baarsma G.S.	2003	TRD@, TRG@
38	Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease. (12730545)	Karasneh J.... Gul A.	2003	IL1B, IL1A, IL1RN
39	Factor V gene (1691A and 4070G) and prothrombin gene 20210A mutations in patients with Behcet's disease. (15170396)	Ates A.... Akar N.	2003	F2, F5
40	Factor V Leiden mutation and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease. (12632020)	Gurgey A.... Boyvat A.	2003	SERPINE1, F5
41	Low serum mannose-binding lectin levels in Behcet's disease. (12918709)	Inanc N.... Direskeneli H.	2003	MBL2
42	Serum levels of soluble TNF-alpha receptor-II (P75), circulating gammadelta T-cells and Adamantiades-Behcet's disease activity. (12918703)	Elezoglou A.V.... Kaklamanis P.G.	2003	TNFRSF1B
43	Mapping the HLA association in Behcet's disease: a role for tumor necrosis factor polymorphisms? (12632436)	Ahmad T.... Jewell D.P.	2003	TNF, HLA-B
44	Sequencing-based typing of HLA-B*51 alleles and the significant association of HLA-B*5101 and -B*5108 with Behcet's disease in Greek patients. (12028538)	Mizuki N.... Inoko H.	2002	HLA-B
45	Activation of extracellular signal regulated kinase 1/2 in human dermal microvascular endothelial cells stimulated by anti-endothelial cell antibodies in sera of patients with Behcet's disease. (12354421)	Lee K.H.... Bang D.	2002	ICAM1, MAPK8, MAPK14
46	Lack of association of HLA-B*51 with a severe disease course in Behcet's disease. (11426025)	Gul A.... Saruhan-Direskeneli G.	2001	HLA-B
47	Macrophage migration inhibitory factor in the cerebrospinal fluid of patients with conventional and optic-spinal forms of multiple sclerosis and neuro-Behcet's disease. (11054496)	Niino M.... Nishihira J.	2000	S100A8
48	Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece. (10440244)	Yabuki K.... Ohno S.	1999	HLA-B
49	Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease. (10513813)	Mizuki N.... Inoko H.	1999	HLA-B
50	Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behcet's disease. (7591872)	Mizuki N.... Inoko H.	1995	TNF, HSPA1L, HLA-B

Genes related to behcet's disease according to GeneCards:

(show top 50)    (show all 185)

id	Symbol	Description	Score	GeneCards Section Context
1	C9orf174	chromosome 9 open reading frame 174	11.1	Aliases & Descriptions
2	RBP3	retinol binding protein 3, interstitial	11.0	Publications
3	MEFV	Mediterranean fever	11.0	Publications
4	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
5	TXK	TXK tyrosine kinase	11.0	Publications
6	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications
7	MICB	MHC class I polypeptide-related sequence B	11.0	Publications
8	KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	11.0	Publications
9	SAG	S-antigen; retina and pineal gland (arrestin)	11.0	Publications
10	CXCR2	chemokine (C-X-C motif) receptor 2	11.0	Publications
11	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0	Publications
12	TEC	tec protein tyrosine kinase	11.0	Publications
13	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
14	ENO1	enolase 1, (alpha)	11.0	Publications
15	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
16	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
17	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
18	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
19	SELL	selectin L	11.0	Publications
20	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
21	LBR	lamin B receptor	11.0
22	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
23	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
24	ADA	adenosine deaminase	11.0	Publications
25	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
26	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
27	TNF	tumor necrosis factor	11.0	Publications
28	SELE	selectin E	11.0	Publications
29	THBD	thrombomodulin	11.0	Publications
30	CP	ceruloplasmin (ferroxidase)	11.0	Publications
31	HSPD1	heat shock 60kDa protein 1 (chaperonin)	11.0	Publications
32	CCL3	chemokine (C-C motif) ligand 3	11.0	Publications
33	IFNA2	interferon, alpha 2	11.0	Publications
34	HSPG2	heparan sulfate proteoglycan 2	11.0
35	LRP2	low density lipoprotein receptor-related protein 2	11.0
36	CRP	C-reactive protein, pentraxin-related	11.0	Publications
37	PON1	paraoxonase 1	11.0
38	IL8	interleukin 8	11.0	Publications
39	IL2RA	interleukin 2 receptor, alpha	11.0
40	IFNA1	interferon, alpha 1	11.0	Publications
41	MBL3P	mannose-binding lectin family member 3, pseudogene	11.0	Publications
42	SUMO4	SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)	11.0	Publications
43	MICA	MHC class I polypeptide-related sequence A	11.0	Functions, Publications
44	UFSP1	UFM1-specific peptidase 1 (non-functional)	11.0
45	KIR2DS3	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3	11.0	Publications
46	KLRC2	killer cell lectin-like receptor subfamily C, member 2	11.0	Publications
47	KIR2DS2	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2	11.0	Publications
48	RNF39	ring finger protein 39	11.0
49	PROZ	protein Z, vitamin K-dependent plasma glycoprotein	11.0	Publications
50	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications

Pathways related to behcet's disease according to GeneDecks:

(show top 50)    (show all 138)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of DAP12 receptors in NK cells10	11.1	KLRD1, KLRC2, KLRC1, HLA-E, HLA-C, HLA-B
2	Immune response_Role of DAP12 receptors in NK cells41	11.0	KIR2DL1, KIR2DL3, KIR2DL4, KIR2DL5A, KLRD1, KLRC2
3	Immune System38	10.9	KIR2DL2, KIR2DS1, KIR2DS2, KIR3DL1, KIR2DS4, KIR3DS1
4	Natural killer cell mediated cytotoxicity20	10.9	IFNA1, KIR3DL2, KIR2DS5, KIR2DS3, KIR2DL1, KIR2DL3
5	Antigen processing and presentation20	10.7	TAP2, KIR2DL3, KIR2DL1, KIR3DL3, KIR3DL2, KIR2DS5
6	Graft-versus-host disease20	10.7	IL2, IL1A, CD28, KIR2DL2, KIR2DL5A, KIR3DL1
7	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.5	TNFRSF1A, CCL3, CCL4, FASLG, IL2RA, IL2
8	Bacterial infections in CF airways41	10.4	TLR2, TLR1, IRF1
9	IL-6 Pathway36	10.0	TNFSF13B, CCL3, CCL2, CCL4, IL8, IL6R
10	NFAT Signaling and Lymphocyte Interactions36	10.0	CCL2, CCL4, IL4, IL23A, IL2, IL1A
11	Th1 Differentiation37	9.9	TLR9, TLR6, TLR4, TLR2, TLR1, LTA
12	RAR-Gamma-RXR-Alpha Degradation36	9.9	LTA, TNFSF13B, CCL18, CCL3, CCL4, IL23A
13	PGC1Alpha Pathway36	9.8	CCL4, MAPK14, IL8, IL4, IL23A, IL2
14	Type I diabetes mellitus20	9.7	IL12B, CD28, TNF, HLA-G, HLA-E, HLA-DRB1
15	TRAF Pathway36	9.6	LTA, NFKB1, TNFSF13B, TNFRSF1B, TNFRSF1A, TNF
16	Autoimmune thyroid disease20	9.6	HLA-G, HLA-E, HLA-DRB1, HLA-C, HLA-B, HLA-A
17	THC Differentiation Pathway36	9.5	CD28, TNFRSF1B, TNFRSF1A, TNF, HLA-DRB1, IFNG
18	Allograft rejection20	9.3	TNF, CD28, HLA-G, HLA-E, HLA-DRB1, HLA-C
19	Th17 Differentiation37	9.2	IL1B, IL17F, IL17A, IL12RB1, IL12B, CD28
20	African trypanosomiasis20	9.2	TLR9, TNF, ICAM1, IFNG, FAS, FASLG
21	Cytokine Network36	9.1	LTA, IL10, TNF, IFNG, IFNA2, IFNA1
22	Akt Signaling36	9.0	CXCR3, LTA, TNFSF13B, TNFRSF1A, TNF, CCL18
23	Toll-like receptor signaling pathway20	9.0	TLR9, TLR6, TLR4, TLR2, TLR1, NFKB1
24	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.9	TGFB1, TLR9, TLR6, TLR4, TLR2, TLR1
25	Endothelin-1 Signaling Pathway36	8.9	EDN1, TNFSF13B, CCL18, CCL3, IL6, IL4
26	Regulation of eIF4 and p70S6K36	8.8	TNFSF13B, CCL18, CCL3, CCL4, MAPK14, MAPK8
27	Malaria20	8.7	TGFB1, TLR9, TLR4, TLR2, DARC, TNF
28	Immune response_IL-1 signaling pathway41	8.6	CP, EDN1, NFKB1, NOS2, TNF, HMOX1
29	Immune response IL-1 signaling pathway10	8.6	SERPINE1, IRF1, IL1A, CP, EDN1, NFKB1
30	MIF Mediated Glucocorticoid Regulation36	8.5	NFKB1, IL12B, IL10, IL15, IL18, IL1A
31	Measles20	8.5	IL2RA, IL2, IL1B, IL1A, IL12B, CD28
32	Molecular Mechanisms of Cancer36	8.5	TGFBR1, TGFB1, LTA, TNFSF13B, TNFRSF1B, TNFRSF13C
33	Pertussis20	8.4	IL12B, IL10, IRF1, ITGB2, IL1A, IL1B
34	all-trans-Retinoic Acid Signaling in Brain36	8.3	IL10, LTA, TNFSF13B, TNF, CCL3, CCL18
35	STAT3 Pathway36	8.2	CCL4, MAPK14, MAPK8, IL8, IL6R, IL6
36	PEDF Induced Signaling36	8.2	TNF, CCL18, CCL3, CCL2, CCL4, IL8
37	Influenza A20	8.1	HLA-DRB1, HSPA1L, ICAM1, IFNG, IFNA2, IFNA1
38	Rheumatoid arthritis20	8.0	CCL2, IL8, IL6, IL23A, IL1B, IL1A
39	Leishmaniasis20	8.0	NFKB1, NOS2, TNF, HLA-DRB1, IFNG, MAPK14
40	MIF Regulation of Innate Immune Cells36	8.0	CCL4, MAPK8, IL8, IL6, IL4, IL23A
41	Glucocorticoid Receptor Signaling36	7.8	IL8, IL6R, IL6, IL4, IL2RA, IL23A
42	Tec Kinases Signaling36	7.8	CXCR3, TGFB1, TLR9, TLR6, TLR4, TLR2
43	Cytokine-cytokine receptor interaction20	7.7	IL12B, IL10, LEP, VEGFA, CXCR3, CXCR2
44	TGF-Beta Pathway36	7.7	TGFBR1, TGFB1, TNFSF13B, TNFRSF1B, TNFRSF1A, IL1A
45	JAK-STAT Pathway36	7.5	CCL18, CCL3, CCL2, CCL4, IL8, IL6R
46	Antioxidant Action of Vitamin-C36	7.5	MAPK8, CD28, FGF2, IL10, IL12B, IL8
47	p38 Signaling36	7.4	CCL18, IL15, IL12RB1, IL12B, IL10, FGF2
48	Tuberculosis20	7.3	NOS2, NOD2, TNFRSF1A, TNF, HLA-DRB1, HSPD1
49	MAPK Family Pathway36	7.2	IL1A, IL18, IL15, IL12RB1, IL12B, IL10
50	Chagas disease (American trypanosomiasis)20	6.8	TGFBR1, TGFB1, TLR9, TLR6, TLR4, TLR2

Compounds related to behcet's disease according to GeneDecks:

(show top 50)    (show all 472)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.8	VWF, SAG, FCGR3A, FASLG, CCL4, CCR5
2	nadph32 18	11.7	SAG, FCGR3B, CYP1A1, CYP2C19
3	mannose32	10.5	KIR2DL2, CLEC4D, LGALS3, CD69, CD163, FCGR2A
4	p00232	10.2	LPA, LEP, MTHFR, MMP9, GSTM1, GSTT1
5	uric acid32 18	10.9	SERPINE1, LPA, LEP, MTHFR, SAA4, XDH
6	glutamate32	9.9	LGALS3, LEP, MTHFR, S100A8, ITGB2, MMP2
7	sulfasalazine32 9 9	11.9	SELE, NAT2, MTHFR, MPO, IL12B, IL1A
8	egcg32	9.9	IL1A, MAPK8, MAPK14, HSPG2, SOD1
9	peptidoglycan32	9.9	IL10, IL12B, IL15, IL1B, IL1RN, IL8
10	n acetylcysteine32	9.9	VWF, SELE, SELP, SERPINC1, MMP2, MMP9
11	epinephrine32 9 18 9	12.8	SELE, SELL, SELP, LEP, LBR, CD69
12	heparin32 9 18 9	12.8	LRP2, VWF, SERPINE1, LPA, LGALS3, LBR
13	con a32	9.8	LBR, CD28, CD69, ITGB2, MMP2, IL10
14	fmlp32	9.7	SELL, SELP, MPO, CD69, ITGB2, FCGR2A
15	calcium32 9 18 9	12.6	VWF, LPA, LGALS3, LBR, SAA1, SAA4
16	gabexate mesilate32	9.4	SELE, SERPINC1, XDH, MMP9, IL10, IL6
17	h2o232	9.4	VWF, SELL, LPA, LGALS3, LEP, LBR
18	valine32	9.3	MTHFR, SAA1, MPO, GSTM1, GSTP1, GSTT1
19	warfarin32 34 9 18 9	13.3	VWF, SELP, SERPINC1, NAT2, LPA, MTHFR
20	betacarotene32	9.2	VWF, NAT2, LEP, MTHFR, GSTM1, IL10
21	fenofibrate32 9 9	11.2	SELE, SELP, SERPINE1, LPA, LEP, MMP9
22	lipoteichoic acid32	9.2	SELE, IL10, IL12B, IL18, IL1B, IL1RN
23	leukotriene b432 42 18	11.1	SELL, SELP, MPO, ITGB2, MMP9, FCGR3B
24	fibrinogen32	9.1	VWF, SELE, SELP, SERPINC1, SERPINE1, LPA
25	neopterin32	9.0	LGALS3BP, LBR, SAA4, IL10, IL18, IL1A
26	wortmannin32 42	10.0	LGALS3, LEP, CD28, ITGB2, MMP2, MMP9
27	poly(i-c)32	8.9	CD69, IRF1, IL12B, IL15, IL18, IL1B
28	losartan32 34 9 9	11.9	VWF, SELE, SELP, SERPINE1, LEP, XDH
29	cholesterol32 9 18 9	11.9	LRP2, VWF, SELE, SELP, SERPINE1, NAT2
30	estrogen32	8.9	VWF, SERPINC1, SERPINE1, NAT2, LPA, LGALS3
31	taurine chloramine32	8.8	MPO, IL1B, IL2, IL6, IL8, IFNG
32	prednisolone32 9 9	10.5	VWF, SELL, MPO, ITGB2, MMP2, GSTM1
33	arginine32	8.5	KIR2DL4, VWF, SERPINC1, LPA, LEP, LBR
34	ciglitazone32	8.4	SERPINE1, MMP2, MMP9, IL1B, IL6, IL8
35	lipid32	8.3	LRP2, KIR2DL1, KIR3DL1, SELE, SERPINE1, LPA
36	ccl332	8.3	MMP9, IL10, IL15, IL18, IL1A, IL1B
37	infliximab32 9 9	10.0	SELE, VEGFA, LBR, FGF2, IL10, IL15
38	4-hydroxynonenal32 18	8.9	XDH, MPO, GSTM1, GSTP1, IL10, APOE
39	il 1032	7.9	IL10, IL12B, IL15, IL18, IL1A, IL1B
40	thalidomide32 42 9 9	10.9	SELL, VEGFA, ITGB2, FGF2, IL10, IL18
41	atorvastatin32 34 9 18 9	11.6	VWF, SELE, SELL, SELP, SERPINE1, VEGFA
42	methotrexate32 34 42 9 9	11.6	SELE, SERPINE1, NAT2, LEP, MTHFR, S100A8
43	thymidine32 18	8.5	LBR, MTHFR, CD69, IRF1, FGF2, IL10
44	cyclosporin a32 42	8.3	VWF, SELP, LEP, LBR, MTHFR, SAG
45	alanine32	7.2	VWF, SELE, SELL, SERPINC1, LGALS3, MVK
46	pdtc32	7.1	SELE, XDH, MMP2, MMP9, IRF1, IL18
47	herbimycin a32 42	8.0	SELE, SELL, CD28, CD69, ITGB2, MMP2
48	retinoic acid32 42 18	8.9	LRP2, KIR2DS4, VWF, RBP3, SELL, SELP
49	indomethacin32 9 9	8.2	SELL, LEP, MPO, ITGB2, IL17A, IL18
50	genistein32 9 18 9	9.0	SELE, SELL, SELP, SERPINE1, VEGFA, LBR

Cellular components related to behcet's disease according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I protein complex	GO:042612	10.8	HLA-G, HLA-E, HLA-C, HLA-B, HLA-A, MICA
2	phagocytic vesicle membrane	GO:030670	10.6	SLC11A1, TLR6, TLR1, HLA-G, HLA-E, HLA-C
3	high-density lipoprotein particle	GO:034364	10.2	PON1, APOH, APOE, APOA1, SAA4, SAA1
4	integral to plasma membrane	GO:005887	10.2	KIR2DS3, SLC11A1, CXCR3, CXCR2, THBD, TLR6
5	ER to Golgi transport vesicle membrane	GO:012507	10.1	HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-E, HLA-G
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	9.8	HLA-G, HLA-E, HLA-DRB1, HLA-C, HLA-B, HLA-A
7	cell surface	GO:009986	9.6	NOD2, TLR2, THBD, TGFB1, CXCR2, ADA
8	external side of plasma membrane	GO:009897	9.0	ADA, IL12RB1, FCGR3A, CD69, CD28, SELP
9	plasma membrane	GO:005886	8.7	TLR4, TXK, HLA-G, HLA-E, HLA-DRB1, HLA-C
10	extracellular region	GO:005576	5.2	CP, F5, IFNG, IFNA2, CCL3, CCL2
11	extracellular space	GO:005615	4.9	ADA, CPB2, CP, PON1, SOD3, SOD1

Biological processes related to behcet's disease according to GeneDecks:

(show top 50)    (show all 90)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of immune response	GO:050776	10.9	HLA-C, KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1
2	cellular defense response	GO:006968	10.7	KLRC2, HLA-G, CCR5, IL4, LGALS3BP, CCR6
3	positive regulation of interferon-gamma production	GO:032729	10.5	IL12B, SLC11A1, TLR4, LTA, IL12RB1, IL18
4	chemokine-mediated signaling pathway	GO:070098	10.5	CCR4, CCL2, CCR6, CXCR1, CCR5, DARC
5	positive regulation of tumor necrosis factor production	GO:032760	10.5	CCL3, IFNG, TNFRSF1A, TLR9, NOD2, TLR2
6	positive regulation of interleukin-12 production	GO:032735	10.4	HSPD1, HLA-G, TLR2, TLR4, IL23A, TLR9
7	positive regulation of interleukin-10 production	GO:032733	10.4	NOD2, TLR4, TLR9, HSPD1, IL4, IL23A
8	positive regulation of tissue remodeling	GO:034105	10.4	IL18, IL15, IL12B, IL2, IL23A
9	positive regulation of NF-kappaB import into nucleus	GO:042346	10.4	IL1B, IL12B, TLR4, TLR9, TLR2, TNF
10	negative regulation of growth of symbiont in host	GO:044130	10.3	IL10, IL12B, IFNG, MBL2, TNF, TLR2
11	positive regulation of inflammatory response	GO:050729	10.3	TLR4, IL18, IL23A, IL15, IL12B, SERPINE1
12	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	GO:002480	10.3	HLA-A, HLA-B, HLA-C, HLA-E, HLA-G
13	positive regulation of interleukin-17 production	GO:032740	10.2	IL2, TGFB1, IL23A, IL18, IL15, NOD2
14	cellular response to interferon-gamma	GO:071346	10.2	NOS2, CCL3, CCL2, IL18, IL12RB1, IL12B
15	interferon-gamma-mediated signaling pathway	GO:060333	10.1	IRF1, IRF5, IFNG, HLA-B, HLA-E, HLA-G
16	cell surface receptor signaling pathway	GO:007166	10.1	KLRD1, IL2RA, MAPK14, CCL2, IFNA2, IFNG
17	neutrophil chemotaxis	GO:030593	10.1	IFNG, CXCR2, SAA1, ITGB2, IL1B, IL8
18	positive regulation of activated T cell proliferation	GO:042104	10.1	IL12B, IL2, IL23A, IL12RB1, IL4, IL18
19	positive regulation of interleukin-8 production	GO:032757	10.1	IL1B, TLR4, TLR9, SERPINE1, CALCA, IL18
20	acute-phase response	GO:006953	10.1	SAA1, CD163, IL1RN, IL6, IL6R, MBL2
21	positive regulation of chemokine production	GO:032722	10.1	TNF, TLR4, TLR9, IL6R, IL6, IL18
22	cellular response to interleukin-1	GO:071347	10.0	NFKB1, ICAM1, CCL3, CCL2, IL8, IL17A
23	immune response	GO:006955	10.0	CCL18, IL18, IL17A, IL15, FCGR3B, FCGR3A
24	response to lipopolysaccharide	GO:032496	9.9	FAS, TNFRSF1A, NGF, SELE, LTA, EDN1
25	lipopolysaccharide-mediated signaling pathway	GO:031663	9.9	TLR2, NOS3, IL1B, CCL3, TGFB1, CCL2
26	positive regulation of nitric oxide biosynthetic process	GO:045429	9.9	IFNG, IL1B, TLR4, TLR2, EDN1, TNF
27	chemotaxis	GO:006935	9.8	S100A8, FGF2, IL4, MAPK14, CCL4, CCR6
28	innate immune response	GO:045087	9.8	LGALS3, MEFV, IL23A, MBL2, NLRP3, IFNA2
29	defense response to bacterium	GO:042742	9.8	SLC11A1, TLR6, TLR1, TLR4, TNFRSF1A, NOS2
30	positive regulation of interleukin-6 production	GO:032755	9.8	IL6, TLR9, HSPD1, IL6R, NOD2, IL1A
31	positive regulation of chemokine biosynthetic process	GO:045080	9.8	HMOX1, TNF, IFNG, IL4, IL1B
32	humoral immune response	GO:006959	9.8	CCL2, IFNG, TREM1, TNF, LTA, CD28
33	negative regulation of inflammatory response	GO:050728	9.7	TNFRSF1B, TNFRSF1A, ADA, APOE, APOA1, IL2
34	response to heat	GO:009408	9.7	CPB2, MICA, CALCA, CCL2, IL1B, MICB
35	cellular response to lipopolysaccharide	GO:071222	9.7	SERPINE1, TLR4, IFNG, GSTP1, IL12B, CCR5
36	cell-cell signaling	GO:007267	9.6	IL15, EDN1, IL17A, LTA, IL18, IL10
37	defense response to Gram-negative bacterium	GO:050829	9.5	NOS2, SLC11A1, TLR4, IL6, IL23A, IL12B
38	cellular response to mechanical stimulus	GO:071260	9.5	TLR4, NFKB1, TNFRSF1A, FAS, IL1B, IL18
39	positive regulation of T cell proliferation	GO:042102	9.4	TNFRSF13C, IL6, IL23A, IL4, CD28, IL12B
40	signal transduction	GO:007165	9.2	TRIM63, CCL18, CCL2, CCR6, CCL4, MAPK14
41	cytokine-mediated signaling pathway	GO:019221	9.1	TNFRSF1A, IL1B, HLA-E, HLA-B, HLA-DRB1, ICAM1
42	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.0	TGFB1, TLR4, ICAM1, TLR9, TLR2, NFKB1
43	response to hypoxia	GO:001666	8.7	MMP9, IL18, IL1A, IL1B, FAS, CCL2
44	positive regulation of angiogenesis	GO:045766	8.7	IL1B, HMOX1, IL1A, FGF2, VEGFA, TNFRSF1A
45	response to drug	GO:042493	8.4	EDN1, CCL2, CPB2, SOD1, TGFB1, LTA
46	blood coagulation	GO:007596	8.4	F5, TREM1, NOS2, IFNA2, F2, SELL
47	inflammatory response	GO:006954	8.4	TLR1, NFKB1, NGF, NLRP3, CRP, DARC
48	anti-apoptosis	GO:006916	8.3	IL1A, IL1B, APOE, FAS, IL2, MPO
49	platelet activation	GO:030168	8.0	VWF, VEGFA, F2, SERPINE1, SELP, SAA1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.1	IL23A, FGF2, SLC11A1, TGFB1, TLR9, TLR4

Molecular functions related to behcet's disease according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class I receptor activity	GO:032393	10.8	HLA-G, HLA-E, HLA-C, HLA-B, HLA-A, MR1
2	transmembrane signaling receptor activity	GO:004888	10.6	KLRD1, TLR1, TLR2, TLR4, TLR6, THBD
3	chemokine receptor activity	GO:004950	10.6	CXCR3, CXCR1, DARC, CCR5, CCR4, CCR6
4	carbohydrate binding	GO:030246	10.3	KLRD1, KLRC2, KLRC1, IL2, FCN2, CD69
5	receptor activity	GO:004872	10.2	THBD, TLR6, TLR4, TLR2, TLR1, DARC
6	protease binding	GO:002020	10.0	TNFRSF1A, TNF, CD28, SERPINE1, SERPINC1, SELL
7	receptor binding	GO:005102	9.6	HLA-A, HLA-B, HLA-G, TNFSF13B, NOS2, LTA
8	heparin binding	GO:008201	8.9	SOD3, CCL2, APOH, APOE, FGF2, MPO
9	protein homodimerization activity	GO:042803	7.7	CRP, NOS2, NFKB1, TGFB1, TAP1, SOD1
10	cytokine activity	GO:005125	7.6	EDN1, IL4, IL6, FASLG, CCL4, IFNA2
11	growth factor activity	GO:008083	7.3	IL4, IL6, F2, NGF, TGFB1, IL2
12	protein binding	GO:005515	4.6	TNFRSF1A, TNFRSF1B, TNFSF13B, DUSP2, PTPN22, SRF