MCID: BLL003
MIFTS: 56

Bell's Palsy malady

Neuronal diseases category

Summaries for Bell's Palsy

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards: Bell's Palsy, also known as bell palsy, is related to adenoma and hyperthyroidism. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Cellular roles of Anthrax toxin and Alpha-defensins. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are skeleton and mortality/aging.

MedlinePlus:33 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:43 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:63 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 33MedlinePlus, 60UMLS, 10DISEASES, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bell's palsy 8 42 43 33
bell palsy 42 60
facial cranial nerve paralysis 42
facial nerve diseases 60
facial nerve palsy 42
facial paralysis 60
bell's palsy 8
antoni's palsy 42
facial palsy 42
bells palsy 10


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Disease Ontology8 DOID:12506
MeSH34 D020330
ICD9CM27 351.0
ICD1025 G51.0

Related Diseases for Bell's Palsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.1GHR, IGF1
2hyperthyroidism30.1IGF1, GHR
3multiple sclerosis30.1MX1, TNF, IFNA1
4lupus erythematosus29.9MX1
5leukemia29.9PARK2, GHR, TNF, IFNA1
6diabetes mellitus29.8IGF1, GHR, TNF
7facial paralysis11.3
8otitis media10.5
9bone fracture10.4
10ectropion10.3
11wegener's granulomatosis10.3
12parotitis10.3
13herpes simplex10.3
14melkersson-rosenthal syndrome10.3
15acoustic neuroma10.3
16cholesteatoma10.3
17hypertension10.3
18neuroma10.3
19carotid artery dissection10.2
20hyperostosis10.2
21familial recurrent peripheral facial palsy10.2
22deafness - ear malformation - facial palsy10.2
23meningitis10.2
24hereditary congenital facial paresis 310.2
25isolated hereditary congenital facial paralysis10.2
26tolosa-hunt syndrome10.2
27anotia facial palsy cardiac defect10.2
28deafness conductive stapedial ear malformation facial palsy10.2
29recurrent peripheral facial palsy10.2
30middle ear adenoma10.1
31petrositis10.1
32amyloidosis10.1
33glomus tumor10.1
34lagophthalmos10.1
35neuritis10.1
36neuroblastoma10.1
37skull base neoplasm10.1
38suppurative otitis media10.1
39tuberculosis10.1
40moebius syndrome10.1
41familial amyloidosis, finnish type10.1
42wernicke-korsakoff syndrome10.1
43treacher collins syndrome10.1
44myofascial pain syndrome10.1
45rosacea10.1
46malignant otitis externa10.1
47polyarteritis nodosa10.1
48lepromatous leprosy10.1
49appendicitis10.1
50cleft palate10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Clinical Features for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Bell's Palsy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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32MalaCards
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MalaCards organs/tissues related to Bell's Palsy:

32
Eye, Brain, Testes, T cells, Bone, Salivary gland

Animal Models for Bell's Palsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bell's Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.5PARK2, CSGALNACT1, TNF, GHR, IGF1, HOXB1
2MP:00107687.0TNF, GHR, NRBP1, IGF1, HOXB1, HOXB2

Publications for Bell's Palsy

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50PubMed
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Articles related to Bell's Palsy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Bell's palsy presenting after a case of Campylobacter enteritis. (23713220)
2013
2
Correlation between the incidence and severity of Bell's palsy and seasonal variations in Taiwan. (23293978)
2013
3
Surgical interventions for the early management of Bell's palsy. (24132718)
2013
4
Comparison of Transcranial Magnetic Stimulation and Electroneuronography Between Bell's Palsy and Ramsay Hunt Syndrome in Their Acute Stages. (23525840)
2013
5
Epidemiologic and clinical features of Bell's palsy among children in Northern California. (22678408)
2012
6
Antiphospholipid antibody-related Bell's palsy in young women. (22434306)
2012
7
Comparative study between combination of famciclovir and prednisolone with prednisolone alone in acute Bell's palsy. (22081178)
2011
8
Clinical characteristics and cerebrospinal fluid parameters in patients with peripheral facial palsy caused by Lyme neuroborreliosis compared with facial palsy of unknown origin (Bell's palsy). (21831262)
2011
9
Re: Prognostic value of electroneurography in Bell's palsy and Ramsay-Hunt's syndrome. (21414163)
2011
10
Increased seroprevalence of Toxoplasma gondii in a population of patients with Bell's palsy: a sceptical interpretation of the results regarding the pathogenesis of facial nerve palsy. (21305313)
2011
11
Prednisolone and acupuncture in Bell's palsy: study protocol for a randomized, controlled trial. (21693007)
2011
12
When the bell tolls on Bell's palsy: finding occult malignancy in acute-onset facial paralysis. (20015776)
2010
13
A comparison of facial nerve disability between patients with Bell's palsy and vestibular schwannoma. (20570521)
2010
14
Case study of Bell's palsy applying complementary treatment within an occupational therapy model. (19222052)
2009
15
Bell's palsy in children: role of the school nurse in early recognition and referral. (19114470)
2008
16
Acupuncture for Bell's palsy. (17943775)
2007
17
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
18
Equilibrium test findings in patients with Bell's palsy. (16457977)
2006
19
Recurrent Bell's palsy in children - Report of two cases. (23120292)
2006
20
The management of Bell's palsy. (16097504)
2005
21
Efficacy of acupuncture and moxibustion in treating Bell's palsy: a multicenter randomized controlled trial in China. (15498373)
2004
22
Long-standing Bell's palsy and ipsilateral conjunctival maltoma. (14755381)
2004
23
The spectrum of cranial neuropathy in patients with Bell's palsy. (15557420)
2004
24
Efficacy of early treatment of Bell's palsy with oral acyclovir and prednisolone. (14600480)
2003
25
Outcome of treatment with valacyclovir and prednisone in patients with Bell's palsy. (12656408)
2003
26
The use of nerve conduction studies in determining the short-term outcome of Bell's palsy. (14556328)
2003
27
Treatment controversies in Bell's palsy. (14870820)
2003
28
Use of electroneurography as a prognostic indicator of Bell's palsy in Chinese patients. (12170167)
2002
29
Bell's palsy: what is the prognostic value of measurements of signal intensity increases with contrast enhancement on MRI? (12012129)
2002
30
Unique case of eleven Bell's palsy episodes. (11913337)
2001
31
Practice parameter: Steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. (11294918)
2001
32
Aciclovir for Bell's palsy (idiopathic facial paralysis). (11406014)
2001
33
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. (10878079)
2000
34
Assessment and management of idiopathic facial (Bell's) palsy: comparison of Nova Scotia family physicians and otolaryngologists. (10709167)
2000
35
Bell's palsy and herpes viruses: to (acyclo)vir or not to (acyclo)vir? (10540031)
1999
36
Atypical Epstein-Barr virus infection associated with Gianotti-Crosti syndrome and Bell's palsy. (10365586)
1999
37
Bell's Palsy-associated blepharospasm relieved by aiding eyelid closure. (8967759)
1996
38
Soluble interleukin 2 receptors in patients with Bell's palsy. (8766741)
1996
39
Peripartum Bell's palsy. (8602097)
1996
40
Differential diagnosis of facial paralysis and Bell's palsy identifiable for dental surgeons--a review of the literature. (9520700)
1996
41
Immunological findings in Bell's palsy. (10774419)
1994
42
Idiopathic facial nerve palsy (Bell's palsy): morphological changes in MRI. (10774391)
1994
43
Distribution of facial nerve conduction velocities in patients with Bell's palsy. (10774437)
1994
44
Diagnosis and treatment for Bell's palsy associated with diabetes mellitus. (7515552)
1994
45
Correlation between gadolinium-enhanced MRI and neurophysiology in Bell's palsy: a preliminary study. (10774388)
1994
46
Gadolinium-enhanced MRI and positron emission tomography in Bell's palsy: a preliminary report. (10774387)
1994
47
Activation of intravascular coagulation in Bell's palsy. (10774425)
1994
48
Cephalic tetanus presenting with incomplete Bell's palsy. (8056552)
1994
49
Inadequacy of transcranial magnetic stimulation in the neurophysiologic assessment of Bell's palsy. (1446584)
1992
50
Treatment for facial neuronitis: a new approach to Bell's palsy. (1716859)
1991

Genetic Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DEFA1, TNF
29.5DEFA1, DEFA3
3
Hide members
8.4MX1, DEFA1, DEFA3, GHR, IFNA1

Compounds for genes affiliated with Bell's Palsy

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ghrp4410.1GHR, IGF1
2hexarelin44 2811.1IGF1, GHR
3pegvisomant44 1111.1IGF1, GHR
4rebif4410.0MX1, IFNA1
5lanreotide44 2811.0GHR, IGF1
6avonex4410.0MX1, IFNA1
7leuprolide acetate4410.0GHR, IGF1
8polaprezinc4410.0IGF1, IFNA1
9betaseron4410.0IFNA1, MX1
10rantes449.9IFNA1, TNF
11serine449.9MX1, TNF
12hbd2449.7DEFA1, DEFA3
13levodopa44 1110.7GHR, IGF1, PARK2
14imiquimod44 28 59 1112.7MX1, TNF, IFNA1
15lactacystin449.7PARK2, GHR, TNF
162,5-oligoadenylate449.7IFNA1, TNF, MX1
17poly(i-c)449.7MX1, TNF, IFNA1
18neopterin449.6MX1, TNF, IFNA1
19ifn-alpha449.6PARK2, MX1, IFNA1
20cabergoline28 44 1111.6IGF1, GHR
21mg 13244 5910.5PARK2, GHR, TNF
22il-12449.5TNF, IFNA1
23calcitriol44 59 11 2412.5IGF1, GHR, TNF
24cycloheximide449.0MX1, IGF1, GHR, TNF, IFNA1
25thymidine44 2410.0IFNA1, TNF, GHR, IGF1
26vegf448.5IFNA1, TNF, IGF1, HOXB2, PARK2
27retinoic acid44 249.4IFNA1, TNF, GHR, IGF1, HOXB1, HOXB2

GO Terms for genes affiliated with Bell's Palsy

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16Gene Ontology
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Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate proteoglycan biosynthetic processGO:05065010.0IGF1, CSGALNACT1
2proteoglycan biosynthetic processGO:0301669.9IGF1, CSGALNACT1
3insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8IGF1, PARK2
5rhombomere 4 developmentGO:0215709.8HOXB2, HOXB1
6positive regulation of mitosisGO:0458409.8IGF1, TNF
7facial nerve structural organizationGO:0216129.8HOXB2, HOXB1
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, GHR
9regulation of multicellular organism growthGO:0400149.6IGF1, GHR

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet