MCID: BLL003
MIFTS: 49

Bell's Palsy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Bell's Palsy

MalaCards integrated aliases for Bell's Palsy:

Name: Bell's Palsy 12 72 49 50 40 14
Bell Palsy 12 49 41 69
Facial Paralysis 49 69
Facial Cranial Nerve Paralysis 49
Idiopathic Facial Palsy 49
Refrigeration Palsy 49
Facial Nerve Palsy 49
Bell's Palsy 12
Antoni's Palsy 49
Facial Palsy 49

Classifications:



External Ids:

Disease Ontology 12 DOID:12506
ICD10 32 G51.0
ICD9CM 34 351.0
MeSH 41 D020330
UMLS 69 C0376175

Summaries for Bell's Palsy

NINDS : 50 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the 7th cranial nerve, one of the facial nerves.  It is the most common cause of facial paralysis. Generally, Bell's palsy affects only one side of the face, however, in rare cases, it can affect both sides.  Symptoms usually begin suddenly and reach their peak within 72 hours, and can range in severity from mild weakness to total paralysis.  Symptoms vary among individuals and include sudden weakness on one side of the face, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, altered taste, and excessive tearing in the eye. Bell’s palsy can cause significant facial distortion. The exact cause of Bell's palsy isn't known, but many scientists believe that reactivation of a dormant viral infection can cause the facial nerve to swell and becomes inflamed.  Several other conditions can cause facial paralysis that might be diagnosed as Bell's palsy.

MalaCards based summary : Bell's Palsy, also known as bell palsy, is related to facial paralysis and essential tremor, and has symptoms including sleeplessness, generalized muscle weakness and vertigo/dizziness. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 Binding Protein 3). The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

NIH Rare Diseases : 49 Bell's palsy is a form of temporary facial paralysis which results from damage or trauma to one of the facial nerves. This disorder is characterized by the sudden onset of facial paralysis that often affects just one side and can cause significant facial distortion. Symptoms vary, but may include twitching, weakness, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, impairment of taste, and excessive tearing in the eye. While the exact cause is unknown, many researchers believe that a virus may lead to swelling of the 7th cranial nerve. Steroids, such as prednisone, may reduce the inflammation and swelling. Other medications used to treat Bell's palsy include acyclovir (to fight viral infections) and aspirin, acetaminophen, or ibuprofen (to relieve pain).Physical therapy, facial massage and acupuncture have also been used. Last updated: 1/22/2016

MedlinePlus : 40 Bell's palsy is the most common cause of facial paralysis. It usually affects just one side of the face. Symptoms appear suddenly and are at their worst about 48 hours after they start. They can range from mild to severe and include Twitching Weakness Paralysis Drooping eyelid or corner of mouth Drooling Dry eye or mouth Excessive tearing in the eye Impaired ability to taste Scientists think that a viral infection makes the facial nerve swell or become inflamed. You are most likely to get Bell's palsy if you are pregnant, diabetic or sick with a cold or flu. Three out of four patients improve without treatment. With or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. NIH: National Institute of Neurological Disorders and Stroke

Disease Ontology : 12 A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).

Wikipedia : 72 Bell\'s palsy is a type of facial paralysis that results in an inability to control the facial muscles... more...

Related Diseases for Bell's Palsy

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to Bell's Palsy

Symptoms & Phenotypes for Bell's Palsy

UMLS symptoms related to Bell's Palsy:


sleeplessness, generalized muscle weakness, vertigo/dizziness, facial paresis, muscle weakness, chronic pain, tremor, syncope, seizures, sciatica, pain, oral manifestations, flaccid muscle tone, headache, back pain, hemifacial paralysis, facial palsy, lower motor neuron, facial palsy, upper motor neuron, ophthalmoplegia, hemiplegia

Drugs & Therapeutics for Bell's Palsy

Drugs for Bell's Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4
27 Botulinum Toxins Phase 4
28 Botulinum Toxins, Type A Phase 4
29 Cholinergic Agents Phase 4
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 onabotulinumtoxinA Phase 4
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 Central Nervous System Depressants Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41 alpha-methyltyrosine Phase 2
42
Prednisone Approved, Vet_approved 53-03-2 5865
43
Menthol Approved Early Phase 1 2216-51-5 16666
44
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
45
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
46
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
47 Antifungal Agents
48 Dermatologic Agents
49 Keratolytic Agents
50 BB 1101

Interventional clinical trials:

(show all 40)

# Name Status NCT ID Phase Drugs
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4 injection of 1% lidocaine, 2mL for facial nerve block
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
10 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
11 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Prednisolone
12 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464 prednisone and valacyclovir treatments
13 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
14 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
15 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106 prednisone- valacyclovir;prednisone-placebo
16 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
17 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
18 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
19 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
20 Myofunctional Therapy in Facial Palsy Completed NCT00989209 Botulinum Toxin Type A
21 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
22 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
23 Complications in Parotid Surgery Completed NCT02486393
24 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
25 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
26 Clinical Research Core Dental Screening Protocol Completed NCT00090818
27 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
28 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
29 Virtual Rehabilitation Program in Peripheral Facial Paralysis Recruiting NCT02892864
30 Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis Recruiting NCT03284125
31 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
32 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
33 Magnetic Correction of Eye Lid Paralysis Recruiting NCT02988856
34 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
35 R. I. S. POS. T. A Recruiting NCT01991665
36 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
37 Surgery or Clincial Follow up, in Patients With Bell' s Palsy Enrolling by invitation NCT02179684
38 Intratympanic Stereoidal Injections for Facial Nerve Palsy Not yet recruiting NCT03371589 Dexamethasone
39 Two Different Surgical Methods of Blepharospasm Not yet recruiting NCT02765113 Early Phase 1
40 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Terminated NCT02741609

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: bell palsy

Genetic Tests for Bell's Palsy

Anatomical Context for Bell's Palsy

MalaCards organs/tissues related to Bell's Palsy:

38
Eye, Testes, Skin, Tongue, Neutrophil, Brain, Cortex

Publications for Bell's Palsy

Articles related to Bell's Palsy:

(show top 50) (show all 635)
# Title Authors Year
1
A Case of Bell's Palsy Complicated by Subsequent Herpes Simplex Virus Encephalitis. ( 29144221 )
2018
2
Delayed facial nerve decompression for severe refractory cases of Bell's palsy: a 25-year experience. ( 29301560 )
2018
3
Prevalence and characteristics of hearing loss in patients diagnosed with Bell's Palsy. ( 29164322 )
2018
4
Prognostic value of the blink reflex test in Bell's palsy and Ramsay-Hunt syndrome. ( 29402606 )
2018
5
Pontine haemorrhage disguised as Bell's palsy. ( 29437741 )
2018
6
The effect of metabolic syndrome on Bell's palsy recovery rate. ( 29374993 )
2018
7
Bell's Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trial. ( 28193257 )
2017
8
Usefulness of High-Resolution 3D Multi-Sequences for Peripheral Facial Palsy: Differentiation Between Bell's Palsy and Ramsay Hunt Syndrome. ( 29135869 )
2017
9
Bell's Palsy. ( 28375913 )
2017
10
Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy. ( 28299208 )
2017
11
High Incidence of Bell's Palsy After Mastoidectomy: A Longitudinal Follow-up Study. ( 29065089 )
2017
12
Management of Bell's palsy. ( 28798513 )
2017
13
A View of the Therapy for Bell's Palsy Based on Molecular Biological Analyses of Facial Muscles. ( 29283103 )
2017
14
Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell's) palsy. ( 28337563 )
2017
15
Onset of bell's palsy in late pregnancy and early puerperium is associated with worse long-term outcomes. ( 28349542 )
2017
16
PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy. ( 28831749 )
2017
17
Does Type 2 Diabetes Mellitus Affect the Healing of Bell's Palsy in Adults? ( 29284561 )
2017
18
Bell's palsy and influenza(H1N1)pdm09 containing vaccines: A self-controlled case series. ( 28467420 )
2017
19
Concurrent pityriasis rosea and Bell's palsy. ( 28115404 )
2017
20
Effect of Age and Severity of Facial Palsy on Taste Thresholds in Bell's Palsy Patients. ( 28417103 )
2017
21
Bell's palsy in children: Current treatment patterns in Australia and New Zealand. A PREDICT study. ( 28177168 )
2017
22
Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient. ( 28495416 )
2017
23
Oxidative Stress and Antioxidant Status in Patients with Bell's Palsy. ( 28680345 )
2017
24
Bell's palsy: excluding serious illness in urgent and emergency care settings. ( 28403702 )
2017
25
Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. ( 28079835 )
2017
26
Proposal of a Video-recording System for the Assessment of Bell's Palsy: Methodology and Preliminary Results. ( 28708795 )
2017
27
Benefits of High-dose Steroida88+a88Hespandera88+a88Mannitol Administration in the Treatment of Bell's Palsy. ( 28068304 )
2017
28
Development of Bell's Palsy After Treatment With Ipilimumab and Nivolumab for Metastatic Melanoma: A Case Report. ( 28926356 )
2017
29
Recurrent Bell's palsy following ventriculoperitoneal shunt insertion: an unusual case to face. ( 29191062 )
2017
30
Increased risk of peripheral arterial occlusive disease in patients with Bell's palsy using population data. ( 29216223 )
2017
31
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. ( 28180070 )
2017
32
Bidirectional association between Bell's palsy and anxiety disorders: A nationwide population-based retrospective cohort study. ( 28359982 )
2017
33
High-dose corticosteroids improve the prognosis of Bell's palsy compared with low-dose corticosteroids: A propensity score analysis. ( 28947095 )
2017
34
Progression of Lyme disease to Bell's Palsy despite treatment with doxycycline. ( 28705754 )
2017
35
Lyme disease and Bell's palsy: an epidemiological study of diagnosis and risk in England. ( 28396367 )
2017
36
Acupuncture and Kinesio Taping for the acute management of Bell's palsy: A case report. ( 29154053 )
2017
37
A Case of Bell's Palsy with an Incidental Finding of a Cerebellopontine Angle Lipoma. ( 27733958 )
2016
38
Do Antiviral Medications Improve Symptoms in the Treatment of Bell's Palsy? ( 27350020 )
2016
39
The role of facial canal diameter in pathogenesis and grade of Bell's palsy: a study by high resolution computed tomography. ( 27217008 )
2016
40
Kabat rehabilitation for Bell's palsy in the elderly. ( 27967288 )
2016
41
Needle Sensation and Personality Factors Influence Therapeutic Effect of Acupuncture for Treating Bell's Palsy: A Secondary Analysis of a Multicenter Randomized Controlled Trial. ( 27453226 )
2016
42
Infections in the differential diagnosis of Bell's palsy: a plea for performing CSF analysis. ( 27530390 )
2016
43
Prevalence of Bell's palsy in Qena Governorate, Egypt. ( 27238882 )
2016
44
Facial nerve palsy including Bell's palsy: Case definitions and guidelines for collection, analysis, and presentation of immunisation safety data. ( 27235092 )
2016
45
Diagnostic and prognostic value of procalcitonin levels in patients with Bell's palsy. ( 26894418 )
2016
46
A general practice approach to Bell's palsy. ( 27806447 )
2016
47
Bell's palsy. ( 27344096 )
2016
48
Bell's Palsy. ( 26611696 )
2016
49
Bell's palsy syndrome: mimics and chameleons. ( 27034243 )
2016
50
Ocular vestibular evoked myogenic potential testing for the prognosis of Bell's palsy. ( 27609665 )
2016

Variations for Bell's Palsy

Expression for Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for Bell's Palsy

GO Terms for Bell's Palsy

Cellular components related to Bell's Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 DEFA1 DEFA3

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.5 DEFA1 DEFA3 MX1
2 antimicrobial humoral response GO:0019730 9.48 DEFA1 DEFA3
3 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.46 DEFA1 DEFA3
4 killing of cells of other organism GO:0031640 9.43 DEFA1 DEFA3
5 antibacterial humoral response GO:0019731 9.4 DEFA1 DEFA3
6 defense response to fungus GO:0050832 9.37 DEFA1 DEFA3
7 innate immune response in mucosa GO:0002227 9.26 DEFA1 DEFA3
8 mitochondrial fission GO:0000266 9.16 MX1 PRKN
9 intracellular estrogen receptor signaling pathway GO:0030520 8.96 DEFA1 DEFA3
10 defense response GO:0006952 8.8 DEFA1 DEFA3 MX1

Sources for Bell's Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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