MCID: BLL003
MIFTS: 60

Bell's Palsy malady

Rare diseases, Neuronal diseases categories
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Summaries for Bell's Palsy

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43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards: Bell's Palsy, also known as bell palsy, is related to hepatitis and essential tremor. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Endochondral Ossification. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are limbs/digits/tail and muscle.

MedlinePlus:34 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:44 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:65 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 34MedlinePlus, 49Orphanet, 62UMLS, 10DISEASES, 58SNOMED-CT, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
bell palsy:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

bell's palsy 8 43 44 34
bell palsy 8 43 49 62
idiopathic facial palsy 43 49
facial paralysis 43 62
facial cranial nerve paralysis 43
facial nerve diseases 62
refrigeration palsy 43
facial nerve palsy 43
bell's palsy 8
antoni's palsy 43
facial palsy 43
bells palsy 10


External Ids:

Disease Ontology8 DOID:12506
ICD9CM27 351.0
MeSH35 D020330
ICD10 via Orphanet26 G51.0
SNOMED-CT via Orphanet59 193093009
UMLS via Orphanet63 C0376175
ICD1025 G51.0

Related Diseases for Bell's Palsy

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17GeneCards, 18GeneDecks
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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.2MX1, GHR, IFNA1
2essential tremor30.2HS1BP3, PARK2
3multiple sclerosis30.2IFNA1, MX1, TNF
4hyperthyroidism30.2GHR, IGF1
5herpes simplex30.1MX1, PARK2, IFNA1
6systemic lupus erythematosus30.0MX1, TNF, IFNA1
7myopathy29.9PARK2, IGF1, PMP22
8diabetes mellitus29.8IGF1, PMP22, TNF, GHR
9leukemia29.8GHR, IFNA1, PARK2, TNF
10otitis media10.5
11recurrent peripheral facial palsy10.4
12hemifacial spasm10.4
13bone fracture10.4
14ectropion10.4
15parotitis10.3
16wegener's granulomatosis10.3
17melkersson-rosenthal syndrome10.3
18acoustic neuroma10.3
19cholesteatoma10.3
20hypertension10.3
21neuroma10.3
22ramsay-hunt syndrome10.3
23carotid artery dissection10.3
24hyperostosis10.3
25deafness - ear malformation - facial palsy10.3
26meningitis10.2
27hereditary congenital facial paresis 310.2
28isolated hereditary congenital facial paralysis10.2
29anotia10.2
30tolosa-hunt syndrome10.2
31anotia facial palsy cardiac defect10.2
32deafness conductive stapedial ear malformation facial palsy10.2
33petrositis10.1
34middle ear adenoma10.1
35adenoma10.1
36amyloidosis10.1
37lagophthalmos10.1
38neuritis10.1
39neuroblastoma10.1
40skull base neoplasm10.1
41suppurative otitis media10.1
42tuberculosis10.1
43familial amyloidosis, finnish type10.1
44moebius syndrome10.1
45abducens palsy10.1
46rosacea10.1
47myofascial pain syndrome10.1
48treacher collins syndrome10.1
49wernicke-korsakoff syndrome10.1
50lepromatous leprosy10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Symptoms for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Bell's Palsy

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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33MalaCards
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MalaCards organs/tissues related to Bell's Palsy:

33
Eye, Brain, Testes, T cells, Bone, Salivary gland

Animal Models for Bell's Palsy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Bell's Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8GHR, TNF, PMP22, IGF1
2MP:00053698.1GHR, PARK2, TNF, PMP22, IGF1

Publications for Bell's Palsy

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52PubMed
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Articles related to Bell's Palsy:

(show top 50)    (show all 499)
idTitleAuthorsYear
1
A case of Bell's palsy associated with blepharospasm. (22494605)
2013
2
The use of the facial clinimetric evaluation scale as a patient-based grading system in Bell's palsy. (23553515)
2013
3
Acupuncture for Bell's palsy: a systematic review and meta-analysis. (21994030)
2012
4
Hyperbaric oxygen therapy for Bell's palsy. (22336830)
2012
5
Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome. (22737966)
2012
6
Comparative study between combination of famciclovir and prednisolone with prednisolone alone in acute Bell's palsy. (22081178)
2011
7
Early deterioration in Bell's palsy: prognosis and effect of prednisolone. (20818286)
2010
8
Epidemiology of Bell's palsy in an Italian Health District: incidence and case-control study. (21253285)
2010
9
Do either corticosteroids or antiviral agents reduce the risk of long-term facial paresis in patients with new-onset Bell's palsy? (19846267)
2010
10
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
11
Correlates of degree of nerve involvement in early Bell's palsy. (19500424)
2009
12
Bell's palsy may have relations to bacterial infection. (18951723)
2009
13
Recovery of facial movement and facial synkinesis in Bell's palsy patients. (19574944)
2009
14
Bell's palsy and Lyme disease. (19843426)
2009
15
Prednisolone or acyclovir in Bell's palsy. (18199872)
2008
16
Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. (17414047)
2007
17
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
18
Nuclear bilateral Bell's palsy and ageusia associated with Mycoplasma pneumoniae pulmonary infection. (15770030)
2005
19
Familial Bell's palsy in females: a phenotype with a predilection for eyelids and lacrimal gland. (16191801)
2005
20
Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. (14985482)
2004
21
Efficacy of acupuncture and moxibustion in treating Bell's palsy: a multicenter randomized controlled trial in China. (15498373)
2004
22
The strong relation between Yanagihara's scores and electroneurography in the acute stage of bell's palsy. (12806311)
2003
23
Diagnosis and management of Bell's palsy. (12602224)
2003
24
Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. (12218634)
2002
25
Bell's palsy. (12230732)
2002
26
Influence of early high-dose steroid treatment on Bell's palsy evolution. (12391494)
2002
27
Effects of climate, latitude, and season on the incidence of Bell's palsy in the US Armed Forces, October 1997 to September 1999. (12076886)
2002
28
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and acyclovir. (12101147)
2002
29
Bell's palsy: electrodiagnostics are not indicative of cerebrospinal fluid abnormalities. (11407851)
2001
30
Unique case of eleven Bell's palsy episodes. (11913337)
2001
31
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. (10878079)
2000
32
Magnetic resonance imaging findings in bilateral Bell's palsy. (11147402)
2000
33
House-Brackmann and Yanagihara grading scores in relation to electroneurographic results in the time course of Bell's palsy. (9870620)
1998
34
Medical management of Bell's palsy. (9360798)
1997
35
Idiopathic facial nerve paralysis (Bell's Palsy) in the Asir Region. (17338006)
1997
36
Bell's Palsy-associated blepharospasm relieved by aiding eyelid closure. (8967759)
1996
37
Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. (8651631)
1996
38
Bell's palsy and visualization of the facial nerve by MRI. (7569382)
1995
39
Auditory brain-stem response audiometry in patients with Bell's palsy. (7634519)
1995
40
Bell's palsy after onset of insulin-like growth factor I therapy in a patient with growth hormone receptor deficiency. (7949603)
1994
41
Immunological findings in Bell's palsy. (10774419)
1994
42
Bell's palsy: an eponym that often leads to confusion. (8264695)
1994
43
Management of Bell's palsy accompanied by diabetes mellitus. (10774435)
1994
44
Bell's palsy: synopsis by an otologist. (10774315)
1994
45
Incidence and risk factors for Bell's palsy in Laredo, Texas: 1974-1982. (8309506)
1993
46
Bell's palsy in pregnancy and the puerperium. (8482941)
1993
47
Virus-associated demyelination in the pathogenesis of Bell's palsy. (1338291)
1992
48
Magnetic stimulation in Bell's palsy. (1800656)
1991
49
Comments regarding prognostic significance of stapes reflex in Bell's palsy, application of electroneuronography in managing Bell's palsy, and tuberculosis of the middle ear in facial paralysis, management of an injured facial nerve following middle ear surgery. (1805644)
1991
50
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978

Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 53QIAGEN, 12EMD Millipore
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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.0TNF
29.7GHR, IGF1
3
Show member pathways
9.6MX1, IFNA1
49.5TNF, IGF1
59.4IFNA1, TNF
6
Show member pathways
9.3MX1, GHR, IFNA1
7
Show member pathways
9.2GHR, TNF, IGF1
89.2GHR, IFNA1, IGF1
99.1TNF, DEFA1
10
Show member pathways
9.1TNF, IFNA1, MX1
11
Show member pathways
9.0DEFA1, DEFA3
129.0DEFA1, DEFA3
13
Show member pathways
8.6GHR, IFNA1, TNF, IGF1

Compounds for genes affiliated with Bell's Palsy

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience
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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ghrp4510.1GHR, IGF1
2hexarelin45 2911.1IGF1, GHR
3pegvisomant45 1111.1GHR, IGF1
4lanreotide45 2911.1IGF1, GHR
5leuprolide acetate4510.1IGF1, GHR
6rebif4510.1IFNA1, MX1
7avonex4510.1MX1, IFNA1
8betaseron4510.1MX1, IFNA1
9cabergoline45 29 1112.0IGF1, GHR
10polaprezinc4510.0IGF1, IFNA1
11bromocriptine45 29 1112.0IGF1, GHR
12dehydroepiandrosterone sulfate459.9GHR, IGF1
13clonidine45 51 29 1112.8GHR, IGF1
14il-12459.8IFNA1, TNF
15indoleamine459.8TNF, IFNA1
16l-nmma459.7IGF1, TNF
17dihydrotestosterone45 29 24 1112.7IGF1, PMP22, GHR
18ribavirin45 51 1111.7IFNA1, MX1
19polyinosinic-polycytidylic acid459.7TNF, IFNA1
20c-peptide459.7GHR, IGF1
21levodopa45 1110.7GHR, PARK2, IGF1
22mycophenolate mofetil45 51 1111.7IFNA1, TNF
23ifn-alpha459.6MX1, IFNA1, PARK2
24octreotide45 61 29 1112.6GHR, IGF1
25imiquimod45 61 29 1112.6TNF, IFNA1, MX1
262,5-oligoadenylate459.6TNF, IFNA1, MX1
27poly(i-c)459.6TNF, IFNA1, MX1
28calcitriol45 61 24 1112.5GHR, TNF, IGF1
29lactacystin459.5GHR, PARK2, TNF
30neopterin459.5TNF, IFNA1, MX1
31protamine459.5GHR, DEFA1
32mg 13245 6110.5TNF, PARK2, GHR
33ccl345 2910.5IFNA1, TNF
34tamoxifen45 51 29 1112.5GHR, IFNA1, IGF1
35hbd2459.4DEFA3, DEFA1
36actinomycin d459.3IFNA1, TNF, IGF1
37steroid459.3IGF1, PMP22, PARK2, GHR
38glutamine459.2IGF1, PARK2, GHR
39anti-fungal459.2DEFA3, DEFA1
40melphalan45 51 1111.1IFNA1, TNF
41alanine459.1PARK2, IFNA1, GHR, MX1
42thymidine45 2410.1IGF1, TNF, IFNA1, GHR
43arginine459.1DEFA3, IGF1, PMP22, GHR
44dexamethasone45 51 29 1112.0IGF1, TNF, IFNA1, GHR
45vegf458.9IFNA1, PARK2, TNF, IGF1
46cycloheximide458.8MX1, GHR, IFNA1, TNF, IGF1
47rantes458.7MX1, IFNA1, TNF, DEFA1
48retinoic acid45 249.7IGF1, PMP22, TNF, IFNA1, GHR
49glucose458.7GHR, PARK2, IGF1, DEFA1
50serine458.0MX1, GHR, IFNA1, PARK2, TNF, PMP22

GO Terms for genes affiliated with Bell's Palsy

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16Gene Ontology
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Cellular components related to Bell's Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GHR, TNF, IGF1, DEFA3

Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:0480099.9GHR, IGF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IGF1, GHR
3regulation of multicellular organism growthGO:0400149.9GHR, IGF1
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8PARK2, IGF1
5negative regulation of viral genome replicationGO:0450719.7TNF, MX1
6positive regulation of mitosisGO:0458409.7TNF, IGF1
7positive regulation of smooth muscle cell proliferationGO:0486619.6TNF, IGF1
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6IGF1, GHR
9response to glucocorticoidGO:0513849.6GHR, TNF
10positive regulation of protein kinase B signalingGO:0518979.2TNF, IGF1
11negative regulation of cell proliferationGO:0082859.2TNF, PMP22, IGF1

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet