MCID: BLL003
MIFTS: 54

Bell's Palsy malady

Rare diseases, Neuronal diseases categories

Aliases & Classifications for Bell's Palsy

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 47Orphanet, 32MedlinePlus, 60UMLS, 27ICD9CM, 55SNOMED-CT, 33MeSH, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Bell's Palsy, Aliases & Descriptions:

Name: Bell's Palsy 9 41 42 32
Bell Palsy 9 41 47 60
Idiopathic Facial Palsy 41 47
Facial Paralysis 41 60
Facial Cranial Nerve Paralysis 41
Facial Nerve Diseases 60
 
Refrigeration Palsy 41
Facial Nerve Palsy 41
Antoni's Palsy 41
Bell's Palsy 9
Facial Palsy 41
Bells Palsy 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
bell palsy:
Inheritance: Not applicable; Prevalence: 1-5/10000 (United States),1-5/10000 (Worldwide),1-5/10000 (Italy),1-5/10000 (Spain),1-5/10000 (Canada),1-5/10000 (Denmark),1-5/10000 (Europe); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy


External Ids:

Disease Ontology9 DOID:12506
ICD9CM27 351.0
MeSH33 D020330
Orphanet47 2810
ICD10 via Orphanet26 G51.0
UMLS via Orphanet61 C0376175
ICD1025 G51.0

Summaries for Bell's Palsy

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NIH Rare Diseases:41 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards based summary: Bell's Palsy, also known as bell palsy, is related to essential tremor and hepatitis. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Endochondral Ossification. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are limbs/digits/tail and muscle.

Disease Ontology:9 A facial paralysis resulting from dysfunction in the cranial nerve vii (facial nerve).

MedlinePlus:32 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:42 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:63 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Related Diseases for Bell's Palsy

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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 309)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor30.4HS1BP3, PARK2
2hepatitis30.3MX1, GHR, IFNA1
3hyperthyroidism30.1GHR, IGF1
4herpes simplex30.0PARK2, IFNA1, MX1
5systemic lupus erythematosus30.0MX1, IFNA1, TNF
6myopathy29.7IGF1, PMP22, PARK2
7leukemia29.5TNF, PARK2, IFNA1, GHR
8lagophthalmos10.5
9recurrent peripheral facial palsy10.5
10skin disease10.4IFNA1
11periodontal disease10.4TNF
12chickenpox10.4
13moebius syndrome10.4
14deafness - ear malformation - facial palsy10.3
15subacute sclerosing panencephalitis10.3IFNA1, MX1
16relapsing-remitting multiple sclerosis10.3MX1, IFNA1
17melkersson-rosenthal syndrome10.3
18van buchem disease10.3
19tolosa-hunt syndrome10.3
20carotid artery dissection10.3
21malignant otitis externa10.3
22cerebritis10.3
23arachnoiditis10.3
24hyperostosis10.3
25otitis externa10.3
26arachnoid cysts10.3
27craniometaphyseal dysplasia10.3
28anotia facial palsy cardiac defect10.3
29deafness conductive stapedial ear malformation facial palsy10.3
30biliary atresia10.2MX1, GHR
31hepatitis b10.2MX1, IFNA1
32isolated hereditary congenital facial paralysis10.2
33viral hepatitis10.2MX1, IFNA1
34urofacial syndrome 110.2
35osteopathia striata with cranial sclerosis10.2
36neurofibromatosis, type 210.2
37johnson neuroectodermal syndrome10.2
38behcet's disease10.2IFNA1, TNF
39growth retardation with deafness and mental retardation due to igf1 deficiency10.2GHR, IGF1
40laron dwarfism10.1GHR, IGF1
41pituitary hormone deficiency, combined, 210.1GHR, IGF1
42influenza10.1DEFA1, IFNA1, MX1
43noonan syndrome 110.1GHR, IGF1
44neuroblastoma10.1
45petrositis10.1
46middle ear adenoma10.1
47adenoma10.1
48labyrinthitis10.1
49sarcoma10.1
50skull base neoplasm10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Symptoms for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Drug clinical trials:

Search ClinicalTrials for Bell's Palsy

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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MalaCards organs/tissues related to Bell's Palsy:

31
Eye, Testes, Brain, Cortex, T cells, Bone, Salivary gland, Cingulate cortex, Neutrophil

Animal Models for Bell's Palsy or affiliated genes

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MGI Mouse Phenotypes related to Bell's Palsy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8GHR, TNF, PMP22, IGF1
2MP:00053698.1GHR, PARK2, TNF, PMP22, IGF1

Publications for Bell's Palsy

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Articles related to Bell's Palsy:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Bell's palsy: aetiology, clinical features and multidisciplinary care. (25857657)
2015
2
Nerve growth factor for Bell's palsy: A meta-analysis. (25574223)
2015
3
Increasing functional connectivity of the anterior cingulate cortex during the course of recovery from Bell's palsy. (25426823)
2015
4
A case of Bell's palsy associated with blepharospasm. (22494605)
2013
5
The use of the facial clinimetric evaluation scale as a patient-based grading system in Bell's palsy. (23553515)
2013
6
Acupuncture for Bell's palsy: a systematic review and meta-analysis. (21994030)
2012
7
Hyperbaric oxygen therapy for Bell's palsy. (22336830)
2012
8
Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome. (22737966)
2012
9
Early deterioration in Bell's palsy: prognosis and effect of prednisolone. (20818286)
2010
10
Epidemiology of Bell's palsy in an Italian Health District: incidence and case-control study. (21253285)
2010
11
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
12
Correlates of degree of nerve involvement in early Bell's palsy. (19500424)
2009
13
Bell's palsy may have relations to bacterial infection. (18951723)
2009
14
Recovery of facial movement and facial synkinesis in Bell's palsy patients. (19574944)
2009
15
Bell's palsy and Lyme disease. (19843426)
2009
16
Recurrent Bell's palsy in a young woman. (18946598)
2008
17
Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. (17414047)
2007
18
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
19
Nuclear bilateral Bell's palsy and ageusia associated with Mycoplasma pneumoniae pulmonary infection. (15770030)
2005
20
Familial Bell's palsy in females: a phenotype with a predilection for eyelids and lacrimal gland. (16191801)
2005
21
Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. (14985482)
2004
22
Efficacy of acupuncture and moxibustion in treating Bell's palsy: a multicenter randomized controlled trial in China. (15498373)
2004
23
The strong relation between Yanagihara's scores and electroneurography in the acute stage of bell's palsy. (12806311)
2003
24
Diagnosis and management of Bell's palsy. (12602224)
2003
25
Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. (12218634)
2002
26
Bell's palsy. (12230732)
2002
27
Influence of early high-dose steroid treatment on Bell's palsy evolution. (12391494)
2002
28
Effects of climate, latitude, and season on the incidence of Bell's palsy in the US Armed Forces, October 1997 to September 1999. (12076886)
2002
29
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and acyclovir. (12101147)
2002
30
Bell's palsy: electrodiagnostics are not indicative of cerebrospinal fluid abnormalities. (11407851)
2001
31
Unique case of eleven Bell's palsy episodes. (11913337)
2001
32
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. (10878079)
2000
33
Magnetic resonance imaging findings in bilateral Bell's palsy. (11147402)
2000
34
House-Brackmann and Yanagihara grading scores in relation to electroneurographic results in the time course of Bell's palsy. (9870620)
1998
35
Medical management of Bell's palsy. (9360798)
1997
36
Idiopathic facial nerve paralysis (Bell's Palsy) in the Asir Region. (17338006)
1997
37
Bell's Palsy-associated blepharospasm relieved by aiding eyelid closure. (8967759)
1996
38
Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. (8651631)
1996
39
Bell's palsy and visualization of the facial nerve by MRI. (7569382)
1995
40
Auditory brain-stem response audiometry in patients with Bell's palsy. (7634519)
1995
41
Bell's palsy after onset of insulin-like growth factor I therapy in a patient with growth hormone receptor deficiency. (7949603)
1994
42
Immunological findings in Bell's palsy. (10774419)
1994
43
Bell's palsy: an eponym that often leads to confusion. (8264695)
1994
44
Management of Bell's palsy accompanied by diabetes mellitus. (10774435)
1994
45
Incidence and risk factors for Bell's palsy in Laredo, Texas: 1974-1982. (8309506)
1993
46
Bell's palsy in pregnancy and the puerperium. (8482941)
1993
47
Virus-associated demyelination in the pathogenesis of Bell's palsy. (1338291)
1992
48
Magnetic stimulation in Bell's palsy. (1800656)
1991
49
Comments regarding prognostic significance of stapes reflex in Bell's palsy, application of electroneuronography in managing Bell's palsy, and tuberculosis of the middle ear in facial paralysis, management of an injured facial nerve following middle ear surgery. (1805644)
1991
50
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978

Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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Pathways related to Bell's Palsy according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
10.0TNF
29.7GHR, IGF1
3
Show member pathways
9.6MX1, IFNA1
49.5TNF, IGF1
59.4IFNA1, TNF
6
Show member pathways
9.3MX1, GHR, IFNA1
7
Show member pathways
9.2GHR, TNF, IGF1
89.2GHR, IFNA1, IGF1
99.1TNF, DEFA1
10
Show member pathways
9.1TNF, IFNA1, MX1
11
Show member pathways
9.0DEFA1, DEFA3
12
Show member pathways
8.6GHR, IFNA1, TNF, IGF1

Compounds for genes affiliated with Bell's Palsy

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Compounds related to Bell's Palsy according to GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ghrp4310.1GHR, IGF1
2hexarelin43 2811.1IGF1, GHR
3pegvisomant43 1211.1GHR, IGF1
4lanreotide43 2811.1IGF1, GHR
5leuprolide acetate4310.1IGF1, GHR
6rebif4310.1IFNA1, MX1
7avonex4310.1MX1, IFNA1
8betaseron4310.1MX1, IFNA1
9cabergoline43 28 1212.0IGF1, GHR
10polaprezinc4310.0IGF1, IFNA1
11bromocriptine43 28 1212.0IGF1, GHR
12dehydroepiandrosterone sulfate439.9GHR, IGF1
13clonidine43 49 28 1212.8GHR, IGF1
14il-12439.8IFNA1, TNF
15indoleamine439.8TNF, IFNA1
16l-nmma439.7IGF1, TNF
17dihydrotestosterone43 28 24 1212.7IGF1, PMP22, GHR
18ribavirin43 49 1211.7IFNA1, MX1
19polyinosinic-polycytidylic acid439.7TNF, IFNA1
20c-peptide439.7GHR, IGF1
21levodopa43 1210.7GHR, PARK2, IGF1
22mycophenolate mofetil43 49 1211.7IFNA1, TNF
23ifn-alpha439.6MX1, IFNA1, PARK2
24octreotide43 59 28 1212.6GHR, IGF1
25imiquimod43 59 28 1212.6TNF, IFNA1, MX1
262,5-oligoadenylate439.6TNF, IFNA1, MX1
27poly(i-c)439.6TNF, IFNA1, MX1
28calcitriol43 59 24 1212.5GHR, TNF, IGF1
29lactacystin439.5GHR, PARK2, TNF
30neopterin439.5TNF, IFNA1, MX1
31protamine439.5GHR, DEFA1
32mg 13243 5910.5TNF, PARK2, GHR
33ccl343 2810.5IFNA1, TNF
34tamoxifen43 49 28 1212.5GHR, IFNA1, IGF1
35hbd2439.4DEFA3, DEFA1
36actinomycin d439.3IFNA1, TNF, IGF1
37steroid439.3IGF1, PMP22, PARK2, GHR
38glutamine439.2IGF1, PARK2, GHR
39anti-fungal439.2DEFA3, DEFA1
40melphalan43 49 1211.1IFNA1, TNF
41alanine439.1PARK2, IFNA1, GHR, MX1
42thymidine43 2410.1IGF1, TNF, IFNA1, GHR
43arginine439.1DEFA3, IGF1, PMP22, GHR
44dexamethasone43 49 28 1212.0IGF1, TNF, IFNA1, GHR
45vegf438.9IFNA1, PARK2, TNF, IGF1
46cycloheximide438.8MX1, GHR, IFNA1, TNF, IGF1
47rantes438.7MX1, IFNA1, TNF, DEFA1
48retinoic acid43 249.7IGF1, PMP22, TNF, IFNA1, GHR
49glucose438.7GHR, PARK2, IGF1, DEFA1
50serine438.0MX1, GHR, IFNA1, PARK2, TNF, PMP22

GO Terms for genes affiliated with Bell's Palsy

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Cellular components related to Bell's Palsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5GHR, TNF, IGF1, DEFA3

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:00480099.9GHR, IGF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9IGF1, GHR
3regulation of multicellular organism growthGO:00400149.9GHR, IGF1
4negative regulation of release of cytochrome c from mitochondriaGO:00902019.8PARK2, IGF1
5negative regulation of viral genome replicationGO:00450719.7TNF, MX1
6positive regulation of mitosisGO:00458409.7TNF, IGF1
7positive regulation of smooth muscle cell proliferationGO:00486619.6TNF, IGF1
8positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6IGF1, GHR
9response to glucocorticoidGO:00513849.6GHR, TNF
10positive regulation of protein kinase B signalingGO:00518979.2TNF, IGF1
11negative regulation of cell proliferationGO:00082859.2TNF, PMP22, IGF1

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet