MCID: BLL003
MIFTS: 63

Bell's Palsy malady

Rare diseases, Neuronal diseases categories

Summaries for Bell's Palsy

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NIH Rare Diseases:43 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards based summary: Bell's Palsy, also known as bell palsy, is related to hepatitis and essential tremor. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Endochondral Ossification. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are limbs/digits/tail and muscle.

Disease Ontology:10 A facial paralysis resulting from dysfunction in the cranial nerve vii (facial nerve).

MedlinePlus:34 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:44 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:65 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 44NINDS, 12DISEASES, 49Orphanet, 34MedlinePlus, 62UMLS, 29ICD9CM, 57SNOMED-CT, 35MeSH, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Bell's Palsy, Aliases & Descriptions:

Name: Bell's Palsy 10 43 44 34 62
Bell Palsy 10 43 49 62
Idiopathic Facial Palsy 43 49
Facial Paralysis 43 62
Facial Palsy 43 62
Facial Cranial Nerve Paralysis 43
Facial Paralysis, Idiopathic 62
 
Facial Nerve Diseases 62
Refrigeration Palsy 43
Facial Nerve Palsy 43
Antoni's Palsy 43
Bell's Palsy 10
Bells Palsy 12


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
bell palsy:
Inheritance: Not applicable; Prevalence: 1-5/10000 (United States),1-5/10000 (Worldwide),1-5/10000 (Italy),1-5/10000 (Spain),1-5/10000 (Canada),1-5/10000 (Denmark),1-5/10000 (Europe); Age of onset: Adolescent,Adult,Elderly; Age of death: normal life expectancy


External Ids:

Disease Ontology10 DOID:12506
ICD9CM29 351.0
MeSH35 D020330
Orphanet49 2810
ICD10 via Orphanet28 G51.0
UMLS via Orphanet63 C0376175
ICD1027 G51, G51.0, G51.8

Related Diseases for Bell's Palsy

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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 309)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.2MX1, GHR, IFNA1
2essential tremor30.2HS1BP3, PARK2
3hyperthyroidism30.2GHR, IGF1
4herpes simplex30.1PARK2, IFNA1, MX1
5leukemia30.1TNF, PARK2, IFNA1, GHR
6systemic lupus erythematosus29.9MX1, IFNA1, TNF
7myopathy29.9IGF1, PMP22, PARK2
8lagophthalmos10.5
9recurrent peripheral facial palsy10.4
10chickenpox10.4
11moebius syndrome10.4
12melkersson-rosenthal syndrome10.3
13van buchem disease10.3
14tolosa-hunt syndrome10.3
15carotid artery dissection10.3
16malignant otitis externa10.3
17cerebritis10.3
18arachnoiditis10.3
19hyperostosis10.3
20otitis externa10.3
21arachnoid cysts10.3
22craniometaphyseal dysplasia10.3
23deafness - ear malformation - facial palsy10.3
24urofacial syndrome 110.2
25osteopathia striata with cranial sclerosis10.2
26neurofibromatosis, type 210.2
27anotia facial palsy cardiac defect10.2
28deafness conductive stapedial ear malformation facial palsy10.2
29johnson neuroectodermal syndrome10.2
30neuroblastoma10.1
31petrositis10.1
32middle ear adenoma10.1
33adenoma10.1
34labyrinthitis10.1
35sarcoma10.1
36skull base neoplasm10.1
37tuberculosis10.1
38familial amyloidosis, finnish type10.1
39abducens palsy10.1
40isolated hereditary congenital facial paralysis10.1
41kawasaki disease10.1
42leprosy10.1
43alopecia10.1
44bone fracture10.1
45keratopathy10.1
46lymphoblastic lymphoma10.1
47rosacea10.1
48myofascial pain syndrome10.1
49wernicke-korsakoff syndrome10.1
50lepromatous leprosy10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Symptoms for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Drug clinical trials:

Search ClinicalTrials for Bell's Palsy

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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MalaCards organs/tissues related to Bell's Palsy:

33
Eye, Testes, Brain, Cortex, T cells, Bone, Salivary gland, Cingulate cortex, Neutrophil

Animal Models for Bell's Palsy or affiliated genes

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MGI Mouse Phenotypes related to Bell's Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8GHR, TNF, PMP22, IGF1
2MP:00053698.1GHR, PARK2, TNF, PMP22, IGF1

Publications for Bell's Palsy

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Articles related to Bell's Palsy:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Bell's palsy: aetiology, clinical features and multidisciplinary care. (25857657)
2015
2
Nerve growth factor for Bell's palsy: A meta-analysis. (25574223)
2015
3
Increasing functional connectivity of the anterior cingulate cortex during the course of recovery from Bell's palsy. (25426823)
2015
4
A case of Bell's palsy associated with blepharospasm. (22494605)
2013
5
The use of the facial clinimetric evaluation scale as a patient-based grading system in Bell's palsy. (23553515)
2013
6
Acupuncture for Bell's palsy: a systematic review and meta-analysis. (21994030)
2012
7
Hyperbaric oxygen therapy for Bell's palsy. (22336830)
2012
8
Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome. (22737966)
2012
9
Early deterioration in Bell's palsy: prognosis and effect of prednisolone. (20818286)
2010
10
Epidemiology of Bell's palsy in an Italian Health District: incidence and case-control study. (21253285)
2010
11
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
12
Correlates of degree of nerve involvement in early Bell's palsy. (19500424)
2009
13
Bell's palsy may have relations to bacterial infection. (18951723)
2009
14
Recovery of facial movement and facial synkinesis in Bell's palsy patients. (19574944)
2009
15
Bell's palsy and Lyme disease. (19843426)
2009
16
Recurrent Bell's palsy in a young woman. (18946598)
2008
17
Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. (17414047)
2007
18
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
19
Nuclear bilateral Bell's palsy and ageusia associated with Mycoplasma pneumoniae pulmonary infection. (15770030)
2005
20
Familial Bell's palsy in females: a phenotype with a predilection for eyelids and lacrimal gland. (16191801)
2005
21
Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. (14985482)
2004
22
Efficacy of acupuncture and moxibustion in treating Bell's palsy: a multicenter randomized controlled trial in China. (15498373)
2004
23
The strong relation between Yanagihara's scores and electroneurography in the acute stage of bell's palsy. (12806311)
2003
24
Diagnosis and management of Bell's palsy. (12602224)
2003
25
Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. (12218634)
2002
26
Bell's palsy. (12230732)
2002
27
Influence of early high-dose steroid treatment on Bell's palsy evolution. (12391494)
2002
28
Effects of climate, latitude, and season on the incidence of Bell's palsy in the US Armed Forces, October 1997 to September 1999. (12076886)
2002
29
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and acyclovir. (12101147)
2002
30
Bell's palsy: electrodiagnostics are not indicative of cerebrospinal fluid abnormalities. (11407851)
2001
31
Unique case of eleven Bell's palsy episodes. (11913337)
2001
32
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. (10878079)
2000
33
Magnetic resonance imaging findings in bilateral Bell's palsy. (11147402)
2000
34
House-Brackmann and Yanagihara grading scores in relation to electroneurographic results in the time course of Bell's palsy. (9870620)
1998
35
Medical management of Bell's palsy. (9360798)
1997
36
Idiopathic facial nerve paralysis (Bell's Palsy) in the Asir Region. (17338006)
1997
37
Bell's Palsy-associated blepharospasm relieved by aiding eyelid closure. (8967759)
1996
38
Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. (8651631)
1996
39
Bell's palsy and visualization of the facial nerve by MRI. (7569382)
1995
40
Auditory brain-stem response audiometry in patients with Bell's palsy. (7634519)
1995
41
Bell's palsy after onset of insulin-like growth factor I therapy in a patient with growth hormone receptor deficiency. (7949603)
1994
42
Immunological findings in Bell's palsy. (10774419)
1994
43
Bell's palsy: an eponym that often leads to confusion. (8264695)
1994
44
Management of Bell's palsy accompanied by diabetes mellitus. (10774435)
1994
45
Incidence and risk factors for Bell's palsy in Laredo, Texas: 1974-1982. (8309506)
1993
46
Bell's palsy in pregnancy and the puerperium. (8482941)
1993
47
Virus-associated demyelination in the pathogenesis of Bell's palsy. (1338291)
1992
48
Magnetic stimulation in Bell's palsy. (1800656)
1991
49
Comments regarding prognostic significance of stapes reflex in Bell's palsy, application of electroneuronography in managing Bell's palsy, and tuberculosis of the middle ear in facial paralysis, management of an injured facial nerve following middle ear surgery. (1805644)
1991
50
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978

Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.0TNF
29.7GHR, IGF1
3
Show member pathways
9.6MX1, IFNA1
49.5TNF, IGF1
59.4IFNA1, TNF
6
Show member pathways
9.3MX1, GHR, IFNA1
7
Show member pathways
9.2GHR, TNF, IGF1
89.2GHR, IFNA1, IGF1
99.1TNF, DEFA1
10
Show member pathways
9.1TNF, IFNA1, MX1
11
Show member pathways
9.0DEFA1, DEFA3
129.0DEFA1, DEFA3
13
Show member pathways
8.6GHR, IFNA1, TNF, IGF1

Compounds for genes affiliated with Bell's Palsy

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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ghrp4510.1GHR, IGF1
2hexarelin45 3011.1IGF1, GHR
3pegvisomant45 1311.1GHR, IGF1
4lanreotide45 3011.1IGF1, GHR
5leuprolide acetate4510.1IGF1, GHR
6rebif4510.1IFNA1, MX1
7avonex4510.1MX1, IFNA1
8betaseron4510.1MX1, IFNA1
9cabergoline45 30 1312.0IGF1, GHR
10polaprezinc4510.0IGF1, IFNA1
11bromocriptine45 30 1312.0IGF1, GHR
12dehydroepiandrosterone sulfate459.9GHR, IGF1
13clonidine45 51 30 1312.8GHR, IGF1
14il-12459.8IFNA1, TNF
15indoleamine459.8TNF, IFNA1
16l-nmma459.7IGF1, TNF
17dihydrotestosterone45 30 26 1312.7IGF1, PMP22, GHR
18ribavirin45 51 1311.7IFNA1, MX1
19polyinosinic-polycytidylic acid459.7TNF, IFNA1
20c-peptide459.7GHR, IGF1
21levodopa45 1310.7GHR, PARK2, IGF1
22mycophenolate mofetil45 51 1311.7IFNA1, TNF
23ifn-alpha459.6MX1, IFNA1, PARK2
24octreotide45 61 30 1312.6GHR, IGF1
25imiquimod45 61 30 1312.6TNF, IFNA1, MX1
262,5-oligoadenylate459.6TNF, IFNA1, MX1
27poly(i-c)459.6TNF, IFNA1, MX1
28calcitriol45 61 26 1312.5GHR, TNF, IGF1
29lactacystin459.5GHR, PARK2, TNF
30neopterin459.5TNF, IFNA1, MX1
31protamine459.5GHR, DEFA1
32mg 13245 6110.5TNF, PARK2, GHR
33ccl345 3010.5IFNA1, TNF
34tamoxifen45 51 30 1312.5GHR, IFNA1, IGF1
35hbd2459.4DEFA3, DEFA1
36actinomycin d459.3IFNA1, TNF, IGF1
37steroid459.3IGF1, PMP22, PARK2, GHR
38glutamine459.2IGF1, PARK2, GHR
39anti-fungal459.2DEFA3, DEFA1
40melphalan45 51 1311.1IFNA1, TNF
41alanine459.1PARK2, IFNA1, GHR, MX1
42thymidine45 2610.1IGF1, TNF, IFNA1, GHR
43arginine459.1DEFA3, IGF1, PMP22, GHR
44dexamethasone45 51 30 1312.0IGF1, TNF, IFNA1, GHR
45vegf458.9IFNA1, PARK2, TNF, IGF1
46cycloheximide458.8MX1, GHR, IFNA1, TNF, IGF1
47rantes458.7MX1, IFNA1, TNF, DEFA1
48retinoic acid45 269.7IGF1, PMP22, TNF, IFNA1, GHR
49glucose458.7GHR, PARK2, IGF1, DEFA1
50serine458.0MX1, GHR, IFNA1, PARK2, TNF, PMP22

GO Terms for genes affiliated with Bell's Palsy

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Cellular components related to Bell's Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.5GHR, TNF, IGF1, DEFA3

Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:00480099.9GHR, IGF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.9IGF1, GHR
3regulation of multicellular organism growthGO:00400149.9GHR, IGF1
4negative regulation of release of cytochrome c from mitochondriaGO:00902019.8PARK2, IGF1
5negative regulation of viral genome replicationGO:00450719.7TNF, MX1
6positive regulation of mitosisGO:00458409.7TNF, IGF1
7positive regulation of smooth muscle cell proliferationGO:00486619.6TNF, IGF1
8positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.6IGF1, GHR
9response to glucocorticoidGO:00513849.6GHR, TNF
10positive regulation of protein kinase B signalingGO:00518979.2TNF, IGF1
11negative regulation of cell proliferationGO:00082859.2TNF, PMP22, IGF1

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet