MCID: BLL003
MIFTS: 64

Bell's Palsy malady

Rare diseases, Neuronal diseases categories
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Summaries for Bell's Palsy

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NIH Rare Diseases:42 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards based summary: Bell's Palsy, also known as bell palsy, is related to essential tremor and hepatitis. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Endochondral Ossification. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are limbs/digits/tail and muscle.

Disease Ontology:8 A facial paralysis resulting from dysfunction in the cranial nerve vii (facial nerve).

MedlinePlus:33 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:43 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:65 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 10DISEASES, 48Orphanet, 33MedlinePlus, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Bell's Palsy, Aliases & Descriptions:

Name: Bell's Palsy 8 42 43 33 62
Bell Palsy 8 42 48 62
Idiopathic Facial Palsy 42 48
Facial Paralysis 42 62
Facial Palsy 42 62
Facial Cranial Nerve Paralysis 42
Facial Paralysis, Idiopathic 62
 
Facial Nerve Diseases 62
Refrigeration Palsy 42
Facial Nerve Palsy 42
Antoni's Palsy 42
Bell's Palsy 8
Bells Palsy 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
bell palsy:
Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:12506
MeSH34 D020330
ICD9CM27 351.0
ICD10 via Orphanet26 G51.0
UMLS via Orphanet63 C0376175
ICD1025 G51, G51.0, G51.8

Related Diseases for Bell's Palsy

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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1essential tremor30.4HS1BP3, PARK2
2hepatitis30.3MX1, GHR, IFNA1
3multiple sclerosis30.2IFNA1, MX1, TNF
4hyperthyroidism30.1GHR, IGF1
5herpes simplex30.1MX1, PARK2, IFNA1
6systemic lupus erythematosus30.0MX1, TNF, IFNA1
7myopathy29.7PARK2, IGF1, PMP22
8diabetes mellitus29.6IGF1, PMP22, TNF, GHR
9leukemia29.5GHR, IFNA1, PARK2, TNF
10lagophthalmos10.5
11recurrent peripheral facial palsy10.4
12skin disease10.4IFNA1
13ectropion10.4
14periodontal disease10.4TNF
15chickenpox10.4
16ramsay-hunt syndrome10.4
17moebius syndrome10.3
18subacute sclerosing panencephalitis10.3MX1, IFNA1
19melkersson-rosenthal syndrome10.3
20tolosa-hunt syndrome10.3
21carotid artery dissection10.3
22arachnoiditis10.3
23malignant otitis externa10.3
24cerebritis10.3
25hyperostosis10.3
26otitis externa10.3
27arachnoid cysts10.3
28relapsing-remitting multiple sclerosis10.3IFNA1, MX1
29deafness - ear malformation - facial palsy10.3
30biliary atresia10.2MX1, GHR
31isolated hereditary congenital facial paralysis10.2
32hepatitis b10.2MX1, IFNA1
33anotia facial palsy cardiac defect10.2
34deafness conductive stapedial ear malformation facial palsy10.2
35viral hepatitis10.2IFNA1, MX1
36behcet's disease10.2IFNA1, TNF
37insulin-like growth factor i deficiency10.2IGF1, GHR
38laron syndrome10.2GHR, IGF1
39panhypopituitarism10.2IGF1, GHR
40middle ear adenoma10.1
41petrositis10.1
42adenoma10.1
43labyrinthitis10.1
44neuroblastoma10.1
45sarcoma10.1
46skull base neoplasm10.1
47tuberculosis10.1
48familial amyloidosis, finnish type10.1
49abducens palsy10.1
50influenza10.1MX1, IFNA1, DEFA1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Symptoms for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Drug clinical trials:

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Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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MalaCards organs/tissues related to Bell's Palsy:

32
Eye, Testes, Brain, T cells, Bone, Cortex, Salivary gland, Neutrophil

Animal Models for Bell's Palsy or affiliated genes

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MGI Mouse Phenotypes related to Bell's Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.8GHR, TNF, PMP22, IGF1
2MP:00053698.1GHR, PARK2, TNF, PMP22, IGF1

Publications for Bell's Palsy

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Articles related to Bell's Palsy:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
A case of Bell's palsy associated with blepharospasm. (22494605)
2013
2
The use of the facial clinimetric evaluation scale as a patient-based grading system in Bell's palsy. (23553515)
2013
3
Acupuncture for Bell's palsy: a systematic review and meta-analysis. (21994030)
2012
4
Hyperbaric oxygen therapy for Bell's palsy. (22336830)
2012
5
Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome. (22737966)
2012
6
Comparative study between combination of famciclovir and prednisolone with prednisolone alone in acute Bell's palsy. (22081178)
2011
7
Early deterioration in Bell's palsy: prognosis and effect of prednisolone. (20818286)
2010
8
Epidemiology of Bell's palsy in an Italian Health District: incidence and case-control study. (21253285)
2010
9
Do either corticosteroids or antiviral agents reduce the risk of long-term facial paresis in patients with new-onset Bell's palsy? (19846267)
2010
10
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
11
Correlates of degree of nerve involvement in early Bell's palsy. (19500424)
2009
12
Bell's palsy may have relations to bacterial infection. (18951723)
2009
13
Recovery of facial movement and facial synkinesis in Bell's palsy patients. (19574944)
2009
14
Bell's palsy and Lyme disease. (19843426)
2009
15
Comparative advantages and shortcomings of corticosteroids in comparison with xylocaine-based perineural blocks in treatment of Bell's palsy. (20088181)
2009
16
Recurrent Bell's palsy in a young woman. (18946598)
2008
17
Prednisolone or acyclovir in Bell's palsy. (18199872)
2008
18
Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. (17414047)
2007
19
On call. Last month I developed severe weakness on the whole left side of my face. My doctor diagnosed Bell's palsy and referred me to a neurologist. I recovered before I got to see her, so I didn't keep the appointment. Although my face is now back to normal, I'd like to know more about the condition. What can you tell me? (17278299)
2006
20
Nuclear bilateral Bell's palsy and ageusia associated with Mycoplasma pneumoniae pulmonary infection. (15770030)
2005
21
Familial Bell's palsy in females: a phenotype with a predilection for eyelids and lacrimal gland. (16191801)
2005
22
Nasal vaccination, Escherichia coli enterotoxin, and Bell's palsy. (14985482)
2004
23
Efficacy of acupuncture and moxibustion in treating Bell's palsy: a multicenter randomized controlled trial in China. (15498373)
2004
24
The strong relation between Yanagihara's scores and electroneurography in the acute stage of bell's palsy. (12806311)
2003
25
Diagnosis and management of Bell's palsy. (12602224)
2003
26
Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. (12218634)
2002
27
Bell's palsy. (12230732)
2002
28
Influence of early high-dose steroid treatment on Bell's palsy evolution. (12391494)
2002
29
Effects of climate, latitude, and season on the incidence of Bell's palsy in the US Armed Forces, October 1997 to September 1999. (12076886)
2002
30
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and acyclovir. (12101147)
2002
31
Bell's palsy: electrodiagnostics are not indicative of cerebrospinal fluid abnormalities. (11407851)
2001
32
Unique case of eleven Bell's palsy episodes. (11913337)
2001
33
Detection of human herpesvirus 6 and varicella-zoster virus in tear fluid of patients with Bell's palsy by PCR. (10878079)
2000
34
Magnetic resonance imaging findings in bilateral Bell's palsy. (11147402)
2000
35
House-Brackmann and Yanagihara grading scores in relation to electroneurographic results in the time course of Bell's palsy. (9870620)
1998
36
Medical management of Bell's palsy. (9360798)
1997
37
Idiopathic facial nerve paralysis (Bell's Palsy) in the Asir Region. (17338006)
1997
38
Bell's Palsy-associated blepharospasm relieved by aiding eyelid closure. (8967759)
1996
39
Bell's palsy treatment with acyclovir and prednisone compared with prednisone alone: a double-blind, randomized, controlled trial. (8651631)
1996
40
Bell's palsy and visualization of the facial nerve by MRI. (7569382)
1995
41
Auditory brain-stem response audiometry in patients with Bell's palsy. (7634519)
1995
42
Bell's palsy after onset of insulin-like growth factor I therapy in a patient with growth hormone receptor deficiency. (7949603)
1994
43
Immunological findings in Bell's palsy. (10774419)
1994
44
Bell's palsy: an eponym that often leads to confusion. (8264695)
1994
45
Management of Bell's palsy accompanied by diabetes mellitus. (10774435)
1994
46
Bell's palsy: synopsis by an otologist. (10774315)
1994
47
Bell's palsy in pregnancy and the puerperium. (8482941)
1993
48
Virus-associated demyelination in the pathogenesis of Bell's palsy. (1338291)
1992
49
Comments regarding prognostic significance of stapes reflex in Bell's palsy, application of electroneuronography in managing Bell's palsy, and tuberculosis of the middle ear in facial paralysis, management of an injured facial nerve following middle ear surgery. (1805644)
1991
50
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978

Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
10.0TNF
29.7GHR, IGF1
3
Show member pathways
9.6MX1, IFNA1
49.5TNF, IGF1
59.4TNF, IFNA1
6
Show member pathways
9.3GHR, IFNA1, MX1
7
Show member pathways
9.2IGF1, GHR, TNF
89.2IFNA1, GHR, IGF1
99.1DEFA1, TNF
10
Show member pathways
9.1TNF, IFNA1, MX1
11
Show member pathways
9.0DEFA1, DEFA3
129.0DEFA3, DEFA1
13
Show member pathways
8.6IGF1, TNF, IFNA1, GHR

Compounds for genes affiliated with Bell's Palsy

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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ghrp4410.1IGF1, GHR
2hexarelin44 2811.1GHR, IGF1
3pegvisomant44 1111.1GHR, IGF1
4leuprolide acetate4410.1IGF1, GHR
5lanreotide44 2811.1GHR, IGF1
6rebif4410.1MX1, IFNA1
7avonex4410.1IFNA1, MX1
8betaseron4410.1MX1, IFNA1
9cabergoline44 28 1112.0GHR, IGF1
10polaprezinc4410.0IGF1, IFNA1
11bromocriptine44 28 1112.0GHR, IGF1
12dehydroepiandrosterone sulfate449.9IGF1, GHR
13clonidine44 50 28 1112.8GHR, IGF1
14il-12449.8TNF, IFNA1
15indoleamine449.8IFNA1, TNF
16dihydrotestosterone44 28 24 1112.8GHR, IGF1, PMP22
17l-nmma449.7IGF1, TNF
18ribavirin44 50 1111.7IFNA1, MX1
19polyinosinic-polycytidylic acid449.7TNF, IFNA1
20c-peptide449.7GHR, IGF1
21levodopa44 1110.7IGF1, GHR, PARK2
22mycophenolate mofetil44 50 1111.7IFNA1, TNF
23ifn-alpha449.6MX1, IFNA1, PARK2
24octreotide44 61 28 1112.6GHR, IGF1
25imiquimod44 61 28 1112.6IFNA1, MX1, TNF
262,5-oligoadenylate449.6IFNA1, TNF, MX1
27poly(i-c)449.6IFNA1, MX1, TNF
28calcitriol44 61 24 1112.5TNF, IGF1, GHR
29lactacystin449.5PARK2, GHR, TNF
30neopterin449.5MX1, IFNA1, TNF
31protamine449.5GHR, DEFA1
32mg 13244 6110.5GHR, PARK2, TNF
33ccl344 2810.5IFNA1, TNF
34tamoxifen44 50 28 1112.5GHR, IFNA1, IGF1
35hbd2449.4DEFA1, DEFA3
36actinomycin d449.3IFNA1, TNF, IGF1
37steroid449.3PMP22, IGF1, GHR, PARK2
38glutamine449.2PARK2, IGF1, GHR
39anti-fungal449.2DEFA3, DEFA1
40melphalan44 50 1111.1IFNA1, TNF
41alanine449.1MX1, GHR, IFNA1, PARK2
42thymidine44 2410.1TNF, GHR, IGF1, IFNA1
43arginine449.1GHR, DEFA3, IGF1, PMP22
44dexamethasone44 50 28 1112.0TNF, GHR, IFNA1, IGF1
45vegf448.9IGF1, IFNA1, TNF, PARK2
46cycloheximide448.8IFNA1, GHR, MX1, TNF, IGF1
47rantes448.7IFNA1, DEFA1, TNF, MX1
48retinoic acid44 249.7PMP22, IGF1, TNF, IFNA1, GHR
49glucose448.7IGF1, DEFA1, GHR, PARK2
50serine448.0TNF, IGF1, PMP22, PARK2, IFNA1, GHR

GO Terms for genes affiliated with Bell's Palsy

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Cellular components related to Bell's Palsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.5GHR, TNF, IGF1, DEFA3

Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor signaling pathwayGO:0480099.9GHR, IGF1
2positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.9IGF1, GHR
3regulation of multicellular organism growthGO:0400149.9GHR, IGF1
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8PARK2, IGF1
5negative regulation of viral genome replicationGO:0450719.7TNF, MX1
6positive regulation of mitosisGO:0458409.7TNF, IGF1
7positive regulation of smooth muscle cell proliferationGO:0486619.6TNF, IGF1
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.6IGF1, GHR
9response to glucocorticoidGO:0513849.6GHR, TNF
10positive regulation of protein kinase B signalingGO:0518979.2TNF, IGF1
11negative regulation of cell proliferationGO:0082859.2TNF, PMP22, IGF1

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet