MCID: BLL003
MIFTS: 56

Bell's Palsy malady

Neuronal diseases category

Summaries for Bell's Palsy

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards: Bell's Palsy, also known as bell palsy, is related to adenoma and hyperthyroidism. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Cellular roles of Anthrax toxin and Alpha-defensins. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are skeleton and mortality/aging.

MedlinePlus:33 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:43 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:63 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 33MedlinePlus, 60UMLS, 10DISEASES, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bell's palsy 8 42 43 33
bell palsy 42 60
facial cranial nerve paralysis 42
facial nerve diseases 60
facial nerve palsy 42
facial paralysis 60
bell's palsy 8
antoni's palsy 42
facial palsy 42
bells palsy 10


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Disease Ontology8 DOID:12506
MeSH34 D020330
ICD9CM27 351.0
ICD1025 G51.0

Related Diseases for Bell's Palsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.1GHR, IGF1
2hyperthyroidism30.1IGF1, GHR
3multiple sclerosis30.1MX1, TNF, IFNA1
4lupus erythematosus29.9MX1
5leukemia29.9PARK2, GHR, TNF, IFNA1
6diabetes mellitus29.8IGF1, GHR, TNF
7facial paralysis11.3
8otitis media10.5
9bone fracture10.4
10ectropion10.3
11wegener's granulomatosis10.3
12parotitis10.3
13herpes simplex10.3
14melkersson-rosenthal syndrome10.3
15acoustic neuroma10.3
16cholesteatoma10.3
17hypertension10.3
18neuroma10.3
19carotid artery dissection10.2
20hyperostosis10.2
21familial recurrent peripheral facial palsy10.2
22deafness - ear malformation - facial palsy10.2
23meningitis10.2
24hereditary congenital facial paresis 310.2
25isolated hereditary congenital facial paralysis10.2
26tolosa-hunt syndrome10.2
27anotia facial palsy cardiac defect10.2
28deafness conductive stapedial ear malformation facial palsy10.2
29recurrent peripheral facial palsy10.2
30middle ear adenoma10.1
31petrositis10.1
32amyloidosis10.1
33glomus tumor10.1
34lagophthalmos10.1
35neuritis10.1
36neuroblastoma10.1
37skull base neoplasm10.1
38suppurative otitis media10.1
39tuberculosis10.1
40moebius syndrome10.1
41familial amyloidosis, finnish type10.1
42wernicke-korsakoff syndrome10.1
43treacher collins syndrome10.1
44myofascial pain syndrome10.1
45rosacea10.1
46malignant otitis externa10.1
47polyarteritis nodosa10.1
48lepromatous leprosy10.1
49appendicitis10.1
50cleft palate10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Clinical Features for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Bell's Palsy

Drug clinical trials:

Search ClinicalTrials for Bell's Palsy

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Search CenterWatch for Bell's Palsy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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32MalaCards
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MalaCards organs/tissues related to Bell's Palsy:

32
Eye, Brain, Testes, T cells, Bone, Salivary gland

Animal Models for Bell's Palsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bell's Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.5PARK2, CSGALNACT1, TNF, GHR, IGF1, HOXB1
2MP:00107687.0TNF, GHR, NRBP1, IGF1, HOXB1, HOXB2

Publications for Bell's Palsy

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50PubMed
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Articles related to Bell's Palsy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Combination therapy for Bell's palsy. (24262737)
2013
2
Unilateral rosacea in a patient with Bell's palsy. (23442008)
2013
3
A systematic review of validated methods for identifying Bell's palsy using administrative or claims data. (24331076)
2013
4
Bell's palsy following primary tooth extraction. A case report. (22803274)
2012
5
The effect of prednisolone on sequelae in Bell's palsy. (22652942)
2012
6
Surgical interventions for the early management of Bell's palsy. (21328293)
2011
7
Surgical treatment of Bell's palsy: current attitudes. (22024853)
2011
8
Bell's palsy. A prospective, longitudinal, descriptive, and observational analysis of prognosis factors for recovery in Mexican patients. (22364035)
2011
9
Bell's palsy: Treatment guidelines. (21847333)
2011
10
Effect of acupuncture combined with blood-letting by a three-edged needle on 50 cases of Bell's palsy at the acute stage. (20653168)
2010
11
Is the width of the labyrinthine portion of the fallopian tube implicated in the pathophysiology of Bell's palsy?: a prospective clinical study using computed tomography. (20513040)
2010
12
Acupuncture for Bell's palsy. (20687071)
2010
13
Prescribe prednisolone alone for Bell's palsy diagnosed within 72 hours of symptom onset. (19201807)
2009
14
Association of herpes simplex virus infection and Bell's palsy. (20201172)
2009
15
Familial recurrent Bell's palsy. (20139511)
2009
16
Bell's palsy before Bell: Evert Jan Thomassen A Thuessink and idiopathic peripheral facial paralysis. (19607737)
2009
17
Remarks on the early history of Bell's palsy. (18704476)
2008
18
Prediction of the prognosis of Bell's palsy using multivariate analyses. (18199959)
2008
19
For Bell's palsy, start steroids early; no need for an antiviral. (18171565)
2008
20
Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. (18849193)
2008
21
Treatment for Bell's palsy. (19094950)
2008
22
Bell's palsy--is glucocorticoid treatment enough? (17942879)
2007
23
Recruitment and retention in a multicentre randomised controlled trial in Bell's palsy: a case study. (17391510)
2007
24
Early treatment with prednisolone or acyclovir in Bell's palsy. (17942873)
2007
25
The phenomenon of the late recovered Bell's palsy: treatment options to improve facial symmetry. (15861048)
2005
26
Aciclovir or valaciclovir for Bell's palsy (idiopathic facial paralysis). (15266457)
2004
27
Differential presence of fibrillation in mimic muscles in Bell's palsy. (15559073)
2004
28
Frequent detection of Mycoplasma pneumoniae in Bell's palsy. (14576947)
2004
29
Recent developments in Bell's palsy: does a more recent single research paper trump a systematic review? (15528634)
2004
30
Diagnosis and management of Bell's palsy. (12602224)
2003
31
Chiropractic care of a patient with vertebral subluxation and Bell's palsy. (12750660)
2003
32
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and acyclovir. (12101147)
2002
33
Bell's palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. (12482166)
2002
34
Oculostapedial synkinesis following Bell's palsy. (10748832)
2000
35
Prognostic factors in patients with idiopathic facial paralysis (Bell's palsy): A prospective study. (10450056)
1999
36
Reactivation of herpes simplex virus type 1 in patients with Bell's palsy. (9515763)
1998
37
The prognostic value of facial nerve conduction velocity in patients with Bell's palsy. (9884805)
1998
38
Bell's palsy and visualization of the facial nerve by MRI. (7569382)
1995
39
Auditory brain-stem response audiometry in patients with Bell's palsy. (7634519)
1995
40
Bell's palsy after onset of insulin-like growth factor I therapy in a patient with growth hormone receptor deficiency. (7949603)
1994
41
Retinal videofluorescence-angiographic findings in Bell's palsy. (10774426)
1994
42
Hysterical hemiparesis accompanying Bell's palsy. (8351026)
1993
43
Acute stage Bell's palsy and narrowing of the palpebral fissure caused by drooping of the eyebrow and the upper eyelid. (1431967)
1992
44
Magnetic facial nerve stimulation in Bell's palsy. (1604998)
1992
45
Bell's palsy. A diagnosis of exclusion. (1862038)
1991
46
Auditory-evoked brain-stem responses and auditory disorders in patients with Bell's palsy. (1747252)
1991
47
Development of Bell's palsy despite treatment of post-traumatic headache by stellate ganglion block. (1673437)
1991
48
Ethics and the care of persons with Bell's palsy. (2017724)
1991
49
Gadolinium-enhanced magnetic resonance imaging in Bell's palsy. (2243515)
1990
50
Significance of taste and electrogustometry in assessing the prognosis of Bell's (idiopathic) facial palsy. (4430866)
1974

Genetic Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DEFA1, TNF
29.5DEFA1, DEFA3
3
Hide members
8.4MX1, DEFA1, DEFA3, GHR, IFNA1

Compounds for genes affiliated with Bell's Palsy

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ghrp4410.1GHR, IGF1
2hexarelin44 2811.1IGF1, GHR
3pegvisomant44 1111.1IGF1, GHR
4rebif4410.0MX1, IFNA1
5lanreotide44 2811.0GHR, IGF1
6avonex4410.0MX1, IFNA1
7leuprolide acetate4410.0GHR, IGF1
8polaprezinc4410.0IGF1, IFNA1
9betaseron4410.0IFNA1, MX1
10rantes449.9IFNA1, TNF
11serine449.9MX1, TNF
12hbd2449.7DEFA1, DEFA3
13levodopa44 1110.7GHR, IGF1, PARK2
14imiquimod44 28 59 1112.7MX1, TNF, IFNA1
15lactacystin449.7PARK2, GHR, TNF
162,5-oligoadenylate449.7IFNA1, TNF, MX1
17poly(i-c)449.7MX1, TNF, IFNA1
18neopterin449.6MX1, TNF, IFNA1
19ifn-alpha449.6PARK2, MX1, IFNA1
20cabergoline28 44 1111.6IGF1, GHR
21mg 13244 5910.5PARK2, GHR, TNF
22il-12449.5TNF, IFNA1
23calcitriol44 59 11 2412.5IGF1, GHR, TNF
24cycloheximide449.0MX1, IGF1, GHR, TNF, IFNA1
25thymidine44 2410.0IFNA1, TNF, GHR, IGF1
26vegf448.5IFNA1, TNF, IGF1, HOXB2, PARK2
27retinoic acid44 249.4IFNA1, TNF, GHR, IGF1, HOXB1, HOXB2

GO Terms for genes affiliated with Bell's Palsy

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16Gene Ontology
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Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate proteoglycan biosynthetic processGO:05065010.0IGF1, CSGALNACT1
2proteoglycan biosynthetic processGO:0301669.9IGF1, CSGALNACT1
3insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8IGF1, PARK2
5rhombomere 4 developmentGO:0215709.8HOXB2, HOXB1
6positive regulation of mitosisGO:0458409.8IGF1, TNF
7facial nerve structural organizationGO:0216129.8HOXB2, HOXB1
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, GHR
9regulation of multicellular organism growthGO:0400149.6IGF1, GHR

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet