MCID: BLL003
MIFTS: 56

Bell's Palsy malady

Neuronal diseases category

Summaries for Bell's Palsy

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42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards: Bell's Palsy, also known as bell palsy, is related to adenoma and hyperthyroidism. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Cellular roles of Anthrax toxin and Alpha-defensins. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotypes are skeleton and mortality/aging.

MedlinePlus:33 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:43 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:63 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

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8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 33MedlinePlus, 60UMLS, 10DISEASES, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

bell's palsy 8 42 43 33
bell palsy 42 60
facial cranial nerve paralysis 42
facial nerve diseases 60
facial nerve palsy 42
facial paralysis 60
bell's palsy 8
antoni's palsy 42
facial palsy 42
bells palsy 10


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Disease Ontology8 DOID:12506
MeSH34 D020330
ICD9CM27 351.0
ICD1025 G51.0

Related Diseases for Bell's Palsy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.1GHR, IGF1
2hyperthyroidism30.1IGF1, GHR
3multiple sclerosis30.1MX1, TNF, IFNA1
4lupus erythematosus29.9MX1
5leukemia29.9PARK2, GHR, TNF, IFNA1
6diabetes mellitus29.8IGF1, GHR, TNF
7facial paralysis11.3
8otitis media10.5
9bone fracture10.4
10ectropion10.3
11wegener's granulomatosis10.3
12parotitis10.3
13herpes simplex10.3
14melkersson-rosenthal syndrome10.3
15acoustic neuroma10.3
16cholesteatoma10.3
17hypertension10.3
18neuroma10.3
19carotid artery dissection10.2
20hyperostosis10.2
21familial recurrent peripheral facial palsy10.2
22deafness - ear malformation - facial palsy10.2
23meningitis10.2
24hereditary congenital facial paresis 310.2
25isolated hereditary congenital facial paralysis10.2
26tolosa-hunt syndrome10.2
27anotia facial palsy cardiac defect10.2
28deafness conductive stapedial ear malformation facial palsy10.2
29recurrent peripheral facial palsy10.2
30middle ear adenoma10.1
31petrositis10.1
32amyloidosis10.1
33glomus tumor10.1
34lagophthalmos10.1
35neuritis10.1
36neuroblastoma10.1
37skull base neoplasm10.1
38suppurative otitis media10.1
39tuberculosis10.1
40moebius syndrome10.1
41familial amyloidosis, finnish type10.1
42wernicke-korsakoff syndrome10.1
43treacher collins syndrome10.1
44myofascial pain syndrome10.1
45rosacea10.1
46malignant otitis externa10.1
47polyarteritis nodosa10.1
48lepromatous leprosy10.1
49appendicitis10.1
50cleft palate10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Clinical Features for Bell's Palsy

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Drugs & Therapeutics for Bell's Palsy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Bell's Palsy

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Bell's Palsy

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Anatomical Context for Bell's Palsy

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32MalaCards
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MalaCards organs/tissues related to Bell's Palsy:

32
Eye, Brain, Testes, T cells, Bone, Salivary gland

Animal Models for Bell's Palsy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Bell's Palsy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.5PARK2, CSGALNACT1, TNF, GHR, IGF1, HOXB1
2MP:00107687.0TNF, GHR, NRBP1, IGF1, HOXB1, HOXB2

Publications for Bell's Palsy

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50PubMed
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Articles related to Bell's Palsy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Combination therapy of steroids and antivirals improves the recovery rate in patients with severe Bell's palsy. (23918692)
2014
2
Isolated Bell's palsy - an unusual presentation of dengue infection. (23317893)
2013
3
Do Oral Steroids Aid Recovery in Children With Bell's Palsy? (24141272)
2013
4
Seasonal Effects on Bell's Palsy: Four-Year Study and Review of the Literature. (23105992)
2012
5
Rowhani-Rahbar et al. Respond to "Immunization and Bell's Palsy in Children" (22411863)
2012
6
Bell's palsy and partial hypoglossal to facial nerve transfer: Case presentation and literature review. (22574255)
2012
7
Do children with Bell's palsy benefit from steroid treatment? A systematic review. (22503409)
2012
8
Prednisolone in Bell's palsy related to treatment start and age. (21099725)
2011
9
Bell's palsy: the answer to the riddle of Leonardo da Vinci's 'Mona Lisa'. (20929717)
2011
10
Bell's palsy in a 3-month-old infant: recommendations for management of pediatric cases. (21323304)
2011
11
Evaluation of the early phase of Bell's palsy using 3A T MRI. (21298392)
2011
12
Epidemiology of Bell's palsy in an Italian Health District: incidence and case-control study. (21253285)
2010
13
Correlates of degree of nerve involvement in early Bell's palsy. (19500424)
2009
14
Bell's palsy may have relations to bacterial infection. (18951723)
2009
15
Recovery of facial movement and facial synkinesis in Bell's palsy patients. (19574944)
2009
16
Idiopathic diaphragmatic paralysis: Bell's palsy of the diaphragm? (19277778)
2009
17
Epidemiology and treatment of Bell's palsy in children in northern Taiwan. (19949760)
2009
18
Outcome of patients presenting with idiopathic facial nerve paralysis (Bell's palsy) in a tertiary centre--a five year experience. (20058577)
2009
19
Effects of exercises on Bell's palsy: systematic review of randomized controlled trials. (18520590)
2008
20
Clinical significance of quantitative analysis of facial nerve enhancement on MRI in Bell's palsy. (18618345)
2008
21
Effect of acupuncture in a patient with 7-year-history of Bell's palsy. (18721078)
2008
22
Bell's palsy and pregnancy. (18036410)
2007
23
Correlation between MRI and operative findings in Bell's palsy and Ramsay Hunt syndrome. (18159587)
2007
24
Denervation pattern of three mimic muscles in Bell's palsy. (17095415)
2006
25
Bell's palsy and parenteral inactivated influenza vaccine. (17012908)
2006
26
Hepatitis E infection with Bell's palsy. (16909746)
2006
27
Recent developments in Bell's palsy: who should provide the care? (15528633)
2004
28
Facial electroneurography on the contralateral side in unilateral Bell's palsy. (12115084)
2002
29
Waveform changes in antidromic facial nerve responses in patients with Bell's palsy. (11860064)
2002
30
Outcome of Bell's palsy in children. (12117022)
2002
31
Lifetime prevalence of Bell's palsy in rural Bolivia: a door-to-door survey. (11901280)
2002
32
Bell's palsy: electrodiagnostics are not indicative of cerebrospinal fluid abnormalities. (11407851)
2001
33
Mouse model of Bell's palsy induced by reactivation of herpes simplex virus type 1. (11398838)
2001
34
Posttraumatic Bell's palsy. (11156823)
2001
35
Bell's palsy: a 10-year experience with antiphlogistic-rheologic infusion therapy. (10821559)
2000
36
Bell's palsy and HSV-1 infection. (10514225)
1999
37
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bell's palsy and prednisolone. (10572822)
1999
38
Does the stapes reflex remain the same after Bell's palsy? (9391674)
1997
39
The clinical problem of Bell's palsy: is treatment with steroids effective? (8995858)
1996
40
Bell's palsy as a sign of Burkitt's lymphoma in children. (7655035)
1995
41
Gd-DPTA enhanced MRI in Bell's palsy and herpes zoster oticus: an overview and implications for future studies. (8928627)
1995
42
Facial nerve enhancement in Gd-MRI in patients with Bell's palsy. (8203223)
1994
43
The possible contributing factors for the success of steroid therapy in Bell's palsy: a clinical and electrophysiological study. (7829945)
1994
44
Lack of association of Bell's palsy and Borrelia burgdorferi antibodies. (8333811)
1993
45
Inflammatory paranasal sinus disease in Bell's palsy demonstrated by magnetic resonance imaging. (8372929)
1993
46
Lyme borreliosis in Bell's palsy. Long Island Neuroborreliosis Collaborative Study Group. (1620330)
1992
47
Bell's palsy in Moebius syndrome. (1911524)
1991
48
Lip-length and snout indices in Bell's palsy. A comparison with the House grading system. (1763627)
1991
49
Medical management of idiopathic (Bell's) palsy. (1762782)
1991
50
Bell's palsy and secondary syphilis: CSF spirochetes detected by immunofluorescence. (365078)
1978

Genetic Variations for Bell's Palsy

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Expression for genes affiliated with Bell's Palsy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DEFA1, TNF
29.5DEFA1, DEFA3
3
Hide members
8.4MX1, DEFA1, DEFA3, GHR, IFNA1

Compounds for genes affiliated with Bell's Palsy

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44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ghrp4410.1GHR, IGF1
2hexarelin44 2811.1IGF1, GHR
3pegvisomant44 1111.1IGF1, GHR
4rebif4410.0MX1, IFNA1
5lanreotide44 2811.0GHR, IGF1
6avonex4410.0MX1, IFNA1
7leuprolide acetate4410.0GHR, IGF1
8polaprezinc4410.0IGF1, IFNA1
9betaseron4410.0IFNA1, MX1
10rantes449.9IFNA1, TNF
11serine449.9MX1, TNF
12hbd2449.7DEFA1, DEFA3
13levodopa44 1110.7GHR, IGF1, PARK2
14imiquimod44 28 59 1112.7MX1, TNF, IFNA1
15lactacystin449.7PARK2, GHR, TNF
162,5-oligoadenylate449.7IFNA1, TNF, MX1
17poly(i-c)449.7MX1, TNF, IFNA1
18neopterin449.6MX1, TNF, IFNA1
19ifn-alpha449.6PARK2, MX1, IFNA1
20cabergoline28 44 1111.6IGF1, GHR
21mg 13244 5910.5PARK2, GHR, TNF
22il-12449.5TNF, IFNA1
23calcitriol44 59 11 2412.5IGF1, GHR, TNF
24cycloheximide449.0MX1, IGF1, GHR, TNF, IFNA1
25thymidine44 2410.0IFNA1, TNF, GHR, IGF1
26vegf448.5IFNA1, TNF, IGF1, HOXB2, PARK2
27retinoic acid44 249.4IFNA1, TNF, GHR, IGF1, HOXB1, HOXB2

GO Terms for genes affiliated with Bell's Palsy

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16Gene Ontology
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Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate proteoglycan biosynthetic processGO:05065010.0IGF1, CSGALNACT1
2proteoglycan biosynthetic processGO:0301669.9IGF1, CSGALNACT1
3insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8IGF1, PARK2
5rhombomere 4 developmentGO:0215709.8HOXB2, HOXB1
6positive regulation of mitosisGO:0458409.8IGF1, TNF
7facial nerve structural organizationGO:0216129.8HOXB2, HOXB1
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, GHR
9regulation of multicellular organism growthGO:0400149.6IGF1, GHR

Products for genes affiliated with Bell's Palsy

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Sources for Bell's Palsy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet