MCID: BLL003
MIFTS: 52

Bell's Palsy malady

Neuronal category

Summaries for Bell's Palsy

Sources:
43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Bell's palsy is a nonprogressive neurological disorder of one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that may be preceded by a slight fever, pain behind the ear on the affected side, a stiff neck, and weakness and/or stiffness on one side of the face. paralysis results from decreased blood supply (ischemia) and/or compression of the 7th cranial nerve. the exact cause of bell's palsy is not known. viral (e.g., herpes zoster virus) and immune disorders are frequently implicated as a cause for this disorder. there may also be an inherited tendency toward developing bell's palsy. while there is no cure or standard course of treatment for bell's palsy, eliminating the source of the nerve damage typically results in a good prognosis. last updated: 1/12/2010

MalaCards: Bell's Palsy, also known as bell palsy, is related to adenoma and idiopathic facial palsy. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 binding protein 3), and among its related pathways are Cellular roles of Anthrax toxin and Alpha-defensins. The drugs scopolamine and scopolamine hydrobromide and the compounds ghrp and hexarelin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and salivary gland, and related mouse phenotypes are skeleton and mortality/aging.

MedlinePlus:34 Bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

NINDS:44 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to one of the facial nerves.

Wikipedia:64 Bell\'s palsy is a form of facial paralysis resulting from a dysfunction of the cranial nerve VII (the... more...

Aliases & Classifications for Bell's Palsy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 34MedlinePlus, 61UMLS, 10DISEASES, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

bell's palsy 8 43 44 34
bell palsy 43 61
facial cranial nerve paralysis 43
facial nerve diseases 61
facial nerve palsy 43
facial paralysis 61
bell's palsy 8
antoni's palsy 43
facial palsy 43
bells palsy 10


External Ids:

Disease Ontology8 DOID:12506
MeSH35 D020330
ICD9CM27 351.0
ICD1025 G51.0

Related Diseases for Bell's Palsy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.1GHR, IGF1
2idiopathic facial palsy10.6
3recurrent peripheral facial palsy10.4
4bone fracture10.4
5hemifacial spasm10.4
6familial recurrent peripheral facial palsy10.4
7parotitis10.3
8melkersson-rosenthal syndrome10.3
9acoustic neuroma10.3
10moebius syndrome10.3
11ramsay-hunt syndrome10.3
12carotid artery dissection10.3
13deafness - ear malformation - facial palsy10.2
14hereditary congenital facial paresis 310.2
15isolated hereditary congenital facial paralysis10.2
16anotia10.2
17tolosa-hunt syndrome10.2
18anotia facial palsy cardiac defect10.2
19deafness conductive stapedial ear malformation facial palsy10.2
20malignant otitis externa10.1
21amyloidosis10.1
22skull base neoplasm10.1
23suppurative otitis media10.1
24tuberculosis10.1
25familial amyloidosis, finnish type10.1
26abducens palsy10.1
27wernicke-korsakoff syndrome10.1
28treacher collins syndrome10.1
29myofascial pain syndrome10.1
30rosacea10.1
31polyarteritis nodosa10.1
32lepromatous leprosy10.1
33appendicitis10.1
34cleft palate10.1
35hepatitis b10.1
36legionnaires' disease10.1
37kawasaki disease10.1
38fibrous dysplasia10.1
39hepatitis a10.1
40alopecia10.1
41toxoplasmosis10.1
42west nile encephalitis10.1
43arachnoid cysts10.1
44hyperostosis corticalis generalisata10.1
45lymphoblastic lymphoma10.1
46neurofibromatosis10.1
47leptospirosis10.1
48urofacial syndrome10.1
49cutaneous anthrax10.1
50chickenpox10.1

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to bell's palsy

Clinical Features for Bell's Palsy

Drugs & Therapeutics for Bell's Palsy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Bell's Palsy

Drug clinical trials:

Search ClinicalTrials for Bell's Palsy

Search NIH Clinical Center for Bell's Palsy

Search CenterWatch for Bell's Palsy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Bell's Palsy

Anatomical Context for Bell's Palsy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Bell's Palsy:

33
Whole blood, Brain, Salivary gland, T cells, Trigeminal ganglion

Animal Models for Bell's Palsy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Bell's Palsy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.5PARK2, CSGALNACT1, TNF, GHR, IGF1, HOXB1
2MP:00107687.0TNF, GHR, NRBP1, IGF1, HOXB1, HOXB2

Publications for Bell's Palsy

Sources:
51PubMed
See all sources

Articles related to Bell's Palsy:

(show top 50)    (show all 212)
idTitleAuthorsYear
1
Combination therapy of steroids and antivirals improves the recovery rate in patients with severe Bell's palsy. (23918692)
2014
2
Prognostic factors of Bell's palsy: prospective patient collected observational study. (23995770)
2013
3
Surgical interventions for the early management of Bell's palsy. (24132718)
2013
4
Steroid-antiviral treatment improves the recovery rate in patients with severe Bell's palsy. (23394867)
2013
5
Value of electroneurography as a prognostic indicator for recovery in acute severe inflammatory facial paralysis: a prospective study of Bell's palsy and Ramsay Hunt syndrome. (23918352)
2013
6
Uncertainties around antivirals in severe Bell's palsy trial. (24262740)
2013
7
Do Oral Steroids Aid Recovery in Children With Bell's Palsy? (24141272)
2013
8
Seasonal Effects on Bell's Palsy: Four-Year Study and Review of the Literature. (23105992)
2012
9
Increased risk of cancer after Bell's palsy: a 5-year follow-up study. (22890970)
2012
10
Re: Prognostic value of electroneurography in Bell's palsy and Ramsay-Hunt's syndrome. (21414163)
2011
11
Increased seroprevalence of Toxoplasma gondii in a population of patients with Bell's palsy: a sceptical interpretation of the results regarding the pathogenesis of facial nerve palsy. (21305313)
2011
12
Bell's palsy: a review of three systematic reviews of steroid and anti-viral therapy. (20447166)
2010
13
Esmail Jorjani (1042-1137) and his descriptions of trigeminal neuralgia, hemifacial spasm, and bell's palsy. (20644430)
2010
14
Varicella zoster virus in Bell's palsy: a prospective study. (20658018)
2010
15
Prescribe prednisolone alone for Bell's palsy diagnosed within 72 hours of symptom onset. (19201807)
2009
16
Simultaneous bilateral Bell's palsy during pregnancy. (19916721)
2009
17
Mouth movement disturbance as a sequela of bilateral Bell's palsy. (19471166)
2009
18
Independent role of hypertension in Bell's palsy: a case-control study. (18756090)
2008
19
For Bell's palsy, start steroids early; no need for an antiviral. (18171565)
2008
20
Clinical prognostic factors for treatment outcome in Bell's palsy: a prospective study. (18788688)
2008
21
Bell's palsy in children: role of the school nurse in early recognition and referral. (19114470)
2008
22
Steroid and antiviral treatment for Bell's palsy. (18514714)
2008
23
Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. (17414047)
2007
24
Long-standing Bell's palsy and ipsilateral conjunctival maltoma. (14755381)
2004
25
Chiropractic care of a patient with vertebral subluxation and Bell's palsy. (12750660)
2003
26
The use of nerve conduction studies in determining the short-term outcome of Bell's palsy. (14556328)
2003
27
Serologic examinations of hepatitis, cytomegalovirus, and rubella in patients with Bell's palsy. (12510182)
2003
28
Secretion and dynamics of herpes simplex virus in tears and saliva of patients with Bell's palsy. (12218634)
2002
29
Annualized incidence and spectrum of illness from an outbreak investigation of Bell's palsy. (12207155)
2002
30
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Electrical stimulation and Bell's palsy. (12204991)
2002
31
Practice parameter: Steroids, acyclovir, and surgery for Bell's palsy (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. (11294918)
2001
32
SjAPgren's syndrome: an unusual cause of Bell's palsy. (11436865)
2001
33
Bell's Palsy - herpes simplex virus type-1 a possible causative agent. (23119516)
1999
34
Geriatrics photo quiz. Bell's palsy (seventh nerve palsy). (9413248)
1997
35
Serial gadolinium-enhanced magnetic resonance imaging and assessment of facial nerve function in Bell's palsy. (9374184)
1997
36
The clinical problem of Bell's palsy: is treatment with steroids effective? (8995858)
1996
37
Bell's palsy: can't whistle, can't spit. (9516249)
1995
38
Salivary flow rate and acute-phase proteins in Bell's palsy. (7530609)
1994
39
Correlation between gadolinium-enhanced MRI and neurophysiology in Bell's palsy: a preliminary study. (10774388)
1994
40
Acyclovir versus steroids in the treatment of Bell's palsy. (10774433)
1994
41
Magnetic transcranial and electrical stylomastoidal stimulation of the facial motor pathways in Bell's palsy: time course and relevance of electrophysiological parameters. (7512917)
1994
42
Treatment of facial muscles affected by Bell's palsy with high-voltage electrical muscle stimulation. (8345319)
1993
43
Case 1: Bell's palsy and persistent loss of taste. Case 2: Bell's palsy, dramatic recovery with high dose steroid therapy. (1443087)
1992
44
Magnetic stimulation in Bell's palsy. (1800656)
1991
45
Comments regarding prognostic significance of stapes reflex in Bell's palsy, application of electroneuronography in managing Bell's palsy, and tuberculosis of the middle ear in facial paralysis, management of an injured facial nerve following middle ear surgery. (1805644)
1991
46
Bell's palsy in Moebius syndrome. (1911524)
1991
47
Conservative treatment of Bell's palsy with steroids and dextran-pentoxiphylline combined therapy. (1709354)
1991
48
Auditory-evoked brain-stem responses and auditory disorders in patients with Bell's palsy. (1747252)
1991
49
Progressive facial nerve fibrosis--recurrent or slowly progressive facial paralysis: atypical Bell's palsy (lima bean in a pea pod) (2285069)
1990
50
Bell's (idiopathic facial) palsy: The nerve excitability test in selection of cases for early treatment. (4430865)
1974

Genetic Variations for Bell's Palsy

Expression for genes affiliated with Bell's Palsy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for genes affiliated with Bell's Palsy

Sources:
38NCBI BioSystems Database, 54Reactome
See all sources

Pathways related to Bell's Palsy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6DEFA1, TNF
29.5DEFA1, DEFA3
3
Hide members
8.4MX1, DEFA1, DEFA3, GHR, IFNA1

Compounds for genes affiliated with Bell's Palsy

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1ghrp4510.1GHR, IGF1
2hexarelin45 2911.1IGF1, GHR
3pegvisomant45 1111.1IGF1, GHR
4rebif4510.0MX1, IFNA1
5lanreotide45 2911.0GHR, IGF1
6avonex4510.0MX1, IFNA1
7leuprolide acetate4510.0GHR, IGF1
8polaprezinc4510.0IGF1, IFNA1
9betaseron4510.0IFNA1, MX1
10rantes459.9IFNA1, TNF
11serine459.9MX1, TNF
12hbd2459.7DEFA1, DEFA3
13levodopa45 1110.7GHR, IGF1, PARK2
14imiquimod45 29 60 1112.7MX1, TNF, IFNA1
15lactacystin459.7PARK2, GHR, TNF
162,5-oligoadenylate459.7IFNA1, TNF, MX1
17poly(i-c)459.7MX1, TNF, IFNA1
18neopterin459.6MX1, TNF, IFNA1
19ifn-alpha459.6PARK2, MX1, IFNA1
20cabergoline29 45 1111.6IGF1, GHR
21mg 13245 6010.5PARK2, GHR, TNF
22il-12459.5TNF, IFNA1
23calcitriol45 60 11 2412.5IGF1, GHR, TNF
24cycloheximide459.0MX1, IGF1, GHR, TNF, IFNA1
25thymidine45 2410.0IFNA1, TNF, GHR, IGF1
26vegf458.5IFNA1, TNF, IGF1, HOXB2, PARK2
27retinoic acid45 249.4IFNA1, TNF, GHR, IGF1, HOXB1, HOXB2

GO Terms for genes affiliated with Bell's Palsy

Sources:
16Gene Ontology
See all sources

Biological processes related to Bell's Palsy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1chondroitin sulfate proteoglycan biosynthetic processGO:05065010.0IGF1, CSGALNACT1
2proteoglycan biosynthetic processGO:0301669.9IGF1, CSGALNACT1
3insulin-like growth factor receptor signaling pathwayGO:0480099.9IGF1, GHR
4negative regulation of release of cytochrome c from mitochondriaGO:0902019.8IGF1, PARK2
5rhombomere 4 developmentGO:0215709.8HOXB2, HOXB1
6positive regulation of mitosisGO:0458409.8IGF1, TNF
7facial nerve structural organizationGO:0216129.8HOXB2, HOXB1
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.8IGF1, GHR
9regulation of multicellular organism growthGO:0400149.6IGF1, GHR

Products for genes affiliated with Bell's Palsy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Bell's Palsy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet