MCID: BLL003
MIFTS: 48

Bell's Palsy malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Bell's Palsy

Aliases & Descriptions for Bell's Palsy:

Name: Bell's Palsy 12 50 51 41 14
Bell Palsy 12 50 42 69
Facial Paralysis 50 69
Facial Cranial Nerve Paralysis 50
Idiopathic Facial Palsy 50
Refrigeration Palsy 50
Facial Nerve Palsy 50
Bell's Palsy 12
Antoni's Palsy 50
Facial Palsy 50

Classifications:



External Ids:

Disease Ontology 12 DOID:12506
ICD10 33 G51.0
ICD9CM 35 351.0
MeSH 42 D020330
UMLS 69 C0376175

Summaries for Bell's Palsy

NINDS : 51 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the 7th cranial nerve, one of the facial nerves.  It is the most common cause of facial paralysis. Generally, Bell's palsy affects only one side of the face, however, in rare cases, it can affect both sides.  Symptoms usually begin suddenly and reach their peak within 72 hours, and can range in severity from mild weakness to total paralysis.  Symptoms vary among individuals and include sudden weakness on one side of the face, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, altered taste, and excessive tearing in the eye. Bell’s palsy can cause significant facial distortion. The exact cause of Bell's palsy isn't known, but many scientists believe that reactivation of a dormant viral infection can cause the facial nerve to swell and becomes inflamed.  Several other conditions can cause facial paralysis that might be diagnosed as Bell's palsy.

MalaCards based summary : Bell's Palsy, also known as bell palsy, is related to recurrent peripheral facial palsy and deafness, conductive stapedial, with ear malformation and facial palsy, and has symptoms including hemiplegia, ophthalmoplegia and oral manifestations. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 Binding Protein 3), and among its related pathways/superpathways are Calcineurin-regulated NFAT-dependent transcription in lymphocytes and IgA-Producing B Cells in the Intestine. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and neutrophil.

NIH Rare Diseases : 50 bell's palsy is a form of temporary facial paralysis which results from damage or trauma to one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that often affects just one side and can cause significant facial distortion. symptoms vary, but may include twitching, weakness, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, impairment of taste, and excessive tearing in the eye. while the exact cause is unknown, many researchers believe that a virus may lead to swelling of the 7th cranial nerve. steroids, such as prednisone, may reduce the inflammation and swelling. other medications used to treat bell's palsy include acyclovir (to fight viral infections) and aspirin, acetaminophen, or ibuprofen (to relieve pain). physical therapy, facial massage and acupuncture have also been used. last updated: 1/22/2016

MedlinePlus : 41 bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

Disease Ontology : 12 A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).

Wikipedia : 71 Bell\'s palsy is a type of facial paralysis that results in an inability to control the facial muscles... more...

Related Diseases for Bell's Palsy

Diseases related to Bell's Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 recurrent peripheral facial palsy 12.0
2 deafness, conductive stapedial, with ear malformation and facial palsy 11.9
3 facial paralysis 11.5
4 van buchem disease 11.3
5 geniculate herpes zoster 11.3
6 sclerosteosis 2 10.8
7 sclerosteosis 1 10.8
8 infundibulocystic basal cell carcinoma 10.1 CD40LG MX1
9 vaginal mullerian papilloma 10.1 CD40LG MX1
10 lipomatosis, multiple symmetric 10.1 CD40LG MX1
11 pseudohypoaldosteronism, type iic 10.1 CD40LG IL2RA
12 benign mediastinal neurilemmoma 10.1 DEFA1 DEFA3
13 lagophthalmos 10.1
14 glomangiosarcoma 10.1 CD40LG PMP22
15 powassan encephalitis 10.1 CD40LG MX1
16 central nervous system origin vertigo 10.1 CD40LG IL2RA
17 sarcomatoid transitional cell carcinoma 10.1 DEFA1 DEFA3
18 female breast nipple and areola cancer 10.1 CD40LG PMP22
19 squamous cell papilloma of skin 10.1 CD40LG IL2RA
20 facial palsy, familial recurrent peripheral 10.1
21 immunoglobulin g deficiency 10.1 CD40LG IL2RA
22 myiasis 10.0 CD40LG IL2RA
23 heart conduction disease 10.0 CD40LG IL2RA
24 anterior foramen magnum meningioma 10.0 CD40LG IL2RA
25 advanced sleep phase syndrome, familial, 1 10.0 CD40LG IL2RA MX1
26 bone fracture 10.0
27 choreatic disease 9.9 CD40LG PMP22
28 relapsing-remitting multiple sclerosis 9.9 CD40LG DEFA1 DEFA3
29 trachoma 9.9 CD40LG MX1
30 otitis externa 9.9
31 melkersson-rosenthal syndrome 9.9
32 chickenpox 9.9
33 benign paroxysmal positional nystagmus 9.7 CD40LG HOXB1 LIPN
34 cardiovascular cancer 9.7 CD40LG HOXB1 LIPN
35 essential tremor 9.7
36 tremor 9.7
37 otitis media 9.7
38 lyme disease 9.7
39 herpes simplex 9.7
40 trichuriasis 8.8 CD40LG DEFA1 DEFA3 HOXB1 HS1BP3 IL2RA

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to Bell's Palsy

Symptoms & Phenotypes for Bell's Palsy

UMLS symptoms related to Bell's Palsy:


hemiplegia, ophthalmoplegia, oral manifestations, sciatica, facial paresis, facial palsy, upper motor neuron, facial palsy, lower motor neuron, hemifacial paralysis, back pain, headache, flaccid muscle tone, pain, seizures, syncope, tremor, chronic pain, muscle weakness, vertigo/dizziness, generalized muscle weakness, sleeplessness

Drugs & Therapeutics for Bell's Palsy

Drugs for Bell's Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4
27 Botulinum Toxins Phase 4
28 Botulinum Toxins, Type A Phase 4
29 Cholinergic Agents Phase 4
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 onabotulinumtoxinA Phase 4
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 Central Nervous System Depressants Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41 Pulmonary Surfactants Phase 3
42 Respiratory System Agents Phase 3
43
Imidacloprid Phase 2 105827-78-9 86418
44 alpha-methyltyrosine Phase 2
45
Prednisone Approved, Vet_approved 53-03-2 5865
46
Menthol Approved Early Phase 1 2216-51-5 16666
47
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
48
Salicylic acid Approved, Vet_approved 69-72-7 338
49 Antifungal Agents
50 Dermatologic Agents

Interventional clinical trials:

(show all 44)
id Name Status NCT ID Phase
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Transfusion of Prematures Trial Recruiting NCT01702805 Phase 3
8 Surfactant Positive Airway Pressure and Pulse Oximetry Trial Active, not recruiting NCT00233324 Phase 3
9 Darbepoetin Trial to Improve Red Cell Mass and Neuroprotection in Preterm Infants Not yet recruiting NCT03169881 Phase 3
10 Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Terminated NCT01192776 Phase 3
11 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
12 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3
13 Benefits of Applying Neuroprosthesis to Improve Grasping and Reaching in Spinal Cord Injury Patients Completed NCT00221117 Phase 2
14 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2
15 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
16 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642
17 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464
18 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
19 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
20 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106
21 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079
22 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
23 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
24 Myofunctional Therapy in Facial Palsy Completed NCT00989209
25 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
26 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
27 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
28 Complications in Parotid Surgery Completed NCT02486393
29 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
30 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
31 Clinical Research Core Dental Screening Protocol Completed NCT00090818
32 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
33 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
34 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
35 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
36 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
37 R. I. S. POS. T. A Recruiting NCT01991665
38 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Recruiting NCT02741609
39 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
40 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Recruiting NCT02856958
41 Magnetic Correction of Eye Lid Paralysis Active, not recruiting NCT02988856
42 Surgery or Clincial Follow up, in Patients With Bell' s Palsy Enrolling by invitation NCT02179684
43 Virtual Rehabilitation Program in Peripheral Facial Paralysis Not yet recruiting NCT02892864
44 Two Different Surgical Methods of Blepharospasm Not yet recruiting NCT02765113 Early Phase 1

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bell palsy

Genetic Tests for Bell's Palsy

Anatomical Context for Bell's Palsy

MalaCards organs/tissues related to Bell's Palsy:

39
Eye, Testes, Neutrophil, Brain, Cortex, T Cells, Cingulate Cortex

Publications for Bell's Palsy

Articles related to Bell's Palsy:

(show top 50) (show all 599)
id Title Authors Year
1
Erratum to: Association Between Statin Use and Bell's Palsy: A Population-Based Study. ( 28083785 )
2017
2
Benefits of High-dose Steroida88+a88Hespandera88+a88Mannitol Administration in the Treatment of Bell's Palsy. ( 28068304 )
2017
3
Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. ( 28079835 )
2017
4
Diagnostic and prognostic value of procalcitonin levels in patients with Bell's palsy. ( 26894418 )
2016
5
Steroid/Antiviral for the treatment of Bell's palsy: Double blind randomized clinical trial. ( 27689547 )
2016
6
Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker. ( 27383276 )
2016
7
Efficacy of Low-Dose Corticosteroid Therapy Versus High-Dose Corticosteroid Therapy in Bell's Palsy in Children. ( 27686096 )
2016
8
Erratum to: Comparison of acyclovir and famciclovir for the treatment of Bell's palsy. ( 27501992 )
2016
9
Bell's palsy. ( 27344096 )
2016
10
Rhinoscintigraphic analysis of nasal mucociliary function in patients with Bell's palsy. ( 27022800 )
2016
11
Bell's palsy at high altitude -- an unsuspected finding. ( 27182447 )
2016
12
Needle Sensation and Personality Factors Influence Therapeutic Effect of Acupuncture for Treating Bell's Palsy: A Secondary Analysis of a Multicenter Randomized Controlled Trial. ( 27453226 )
2016
13
Do Antiviral Medications Improve Symptoms in the Treatment of Bell's Palsy? ( 27350020 )
2016
14
Corticosteroids for Bell's palsy (idiopathic facial paralysis). ( 27428352 )
2016
15
Comparison of acyclovir and famciclovir for the treatment of Bell's palsy. ( 26873601 )
2016
16
The role of facial canal diameter in pathogenesis and grade of Bell's palsy: a study by high resolution computed tomography. ( 27217008 )
2016
17
A Case of Bell's Palsy with an Incidental Finding of a Cerebellopontine Angle Lipoma. ( 27733958 )
2016
18
Bell's palsy syndrome: mimics and chameleons. ( 27034243 )
2016
19
Kabat rehabilitation for Bell's palsy in the elderly. ( 27967288 )
2016
20
Functional Connectivity Modulation by Acupuncture in Patients with Bell's Palsy. ( 27293461 )
2016
21
Role of Kabat rehabilitation in facial nerve palsy: a randomised study on severe cases of Bell's palsy. ( 27734980 )
2016
22
Are corticosteroids useful in all degrees of severity and rapid recovery of Bell's palsy? ( 27003272 )
2016
23
Letter to the Editor concerning "New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio". ( 27994931 )
2016
24
Help Desk Answers: Do corticosteroids relieve Bell's palsy? ( 27158696 )
2016
25
Facial nerve palsy including Bell's palsy: Case definitions and guidelines for collection, analysis, and presentation of immunisation safety data. ( 27235092 )
2016
26
Association between recovery from Bell's palsy and body mass index. ( 27886463 )
2016
27
Infections in the differential diagnosis of Bell's palsy: a plea for performing CSF analysis. ( 27530390 )
2016
28
Bell's Palsy. ( 26611696 )
2016
29
Mandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer. ( 28025626 )
2016
30
A general practice approach to Bell's palsy. ( 27806447 )
2016
31
Ocular vestibular evoked myogenic potential testing for the prognosis of Bell's palsy. ( 27609665 )
2016
32
The Effectiveness of Neural Therapy in Patients With Bell's Palsy. ( 27547166 )
2016
33
Prevalence of Bell's palsy in Qena Governorate, Egypt. ( 27238882 )
2016
34
Synkinesis in Bell's palsy in a randomised controlled trial. ( 27882653 )
2016
35
Prognostic factors for recovery in Portuguese patients with Bell's palsy. ( 27426639 )
2016
36
Neutrophil to lymphocyte ratio in Bell's palsy. ( 27368462 )
2016
37
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. ( 26889221 )
2016
38
Antiviral treatment for Bell's palsy? ( 25907275 )
2015
39
Delayed surgical management is not effective for severe Bell's palsy after two months of onset. ( 26514341 )
2015
40
Reply to the Letter to the Editor: Intratympanic Steroid Injection for Bell's Palsy: Some Issues Highlighted. ( 26375983 )
2015
41
Rehabilitation of Bell's palsy patient with complete dentures. ( 26538967 )
2015
42
Involvement of MAPK ERK Activation in Upregulation of Water Channel Protein Aquaporin 1 in a Mouse Model of Bell's Palsy. ( 25527444 )
2015
43
Guillain-BarrAc syndrome presenting as Bell's palsy with crossed hemiparesis. ( 25810972 )
2015
44
Effects of Wind Chill Factor, Temperature and Other Meteorological Parameters on the Incidence of Bell's Palsy: Results Based on a Retrospective, 7-Year Long, Greek Population Study. ( 26227431 )
2015
45
Antiviral treatment for Bell's palsy (idiopathic facial paralysis). ( 26517150 )
2015
46
Bell's palsy in association with a cerebellar arachnoid cyst. ( 25878242 )
2015
47
Prosthodontic Rehabilitation of Patients with Bell's Palsy: Our Experience. ( 26668488 )
2015
48
Antiviral agents convey added benefit over steroids alone in Bell's palsy; decompression should be considered in patients who are not recovering. ( 25907276 )
2015
49
Antiviral treatment for Bell's palsy (idiopathic facial paralysis). ( 26559436 )
2015
50
New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio. ( 26167340 )
2015

Variations for Bell's Palsy

Expression for Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for Bell's Palsy

Pathways related to Bell's Palsy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.04 CD40LG IL2RA
2 10.8 CD40LG IL2RA
3 10.14 CD40LG IL2RA

GO Terms for Bell's Palsy

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.48 DEFA1 DEFA3
2 positive regulation of T cell proliferation GO:0042102 9.46 CD40LG IL2RA
3 antimicrobial humoral response GO:0019730 9.43 DEFA1 DEFA3
4 antibacterial humoral response GO:0019731 9.4 DEFA1 DEFA3
5 killing of cells of other organism GO:0031640 9.37 DEFA1 DEFA3
6 defense response to virus GO:0051607 9.33 DEFA1 DEFA3 MX1
7 defense response to fungus GO:0050832 9.32 DEFA1 DEFA3
8 innate immune response in mucosa GO:0002227 9.26 DEFA1 DEFA3
9 intracellular estrogen receptor signaling pathway GO:0030520 8.96 DEFA1 DEFA3
10 defense response GO:0006952 8.8 DEFA1 DEFA3 MX1

Sources for Bell's Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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