MCID: BLL003
MIFTS: 45

Bell's Palsy

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Bell's Palsy

MalaCards integrated aliases for Bell's Palsy:

Name: Bell's Palsy 12 50 51 41 14
Bell Palsy 12 50 42 69
Facial Paralysis 50 69
Facial Cranial Nerve Paralysis 50
Idiopathic Facial Palsy 50
Refrigeration Palsy 50
Facial Nerve Palsy 50
Bell's Palsy 12
Antoni's Palsy 50
Facial Palsy 50

Classifications:



External Ids:

Disease Ontology 12 DOID:12506
ICD10 33 G51.0
ICD9CM 35 351.0
MeSH 42 D020330
UMLS 69 C0376175

Summaries for Bell's Palsy

NINDS : 51 Bell's palsy is a form of temporary facial paralysis resulting from damage or trauma to the 7th cranial nerve, one of the facial nerves.  It is the most common cause of facial paralysis. Generally, Bell's palsy affects only one side of the face, however, in rare cases, it can affect both sides.  Symptoms usually begin suddenly and reach their peak within 72 hours, and can range in severity from mild weakness to total paralysis.  Symptoms vary among individuals and include sudden weakness on one side of the face, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, altered taste, and excessive tearing in the eye. Bell’s palsy can cause significant facial distortion. The exact cause of Bell's palsy isn't known, but many scientists believe that reactivation of a dormant viral infection can cause the facial nerve to swell and becomes inflamed.  Several other conditions can cause facial paralysis that might be diagnosed as Bell's palsy.

MalaCards based summary : Bell's Palsy, also known as bell palsy, is related to recurrent peripheral facial palsy and deafness, conductive stapedial, with ear malformation and facial palsy, and has symptoms including hemiplegia, ophthalmoplegia and oral manifestations. An important gene associated with Bell's Palsy is HS1BP3 (HCLS1 Binding Protein 3). The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Disease Ontology : 12 A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve).

NIH Rare Diseases : 50 bell's palsy is a form of temporary facial paralysis which results from damage or trauma to one of the facial nerves. this disorder is characterized by the sudden onset of facial paralysis that often affects just one side and can cause significant facial distortion. symptoms vary, but may include twitching, weakness, drooping eyelid or corner of the mouth, drooling, dry eye or mouth, impairment of taste, and excessive tearing in the eye. while the exact cause is unknown, many researchers believe that a virus may lead to swelling of the 7th cranial nerve. steroids, such as prednisone, may reduce the inflammation and swelling. other medications used to treat bell's palsy include acyclovir (to fight viral infections) and aspirin, acetaminophen, or ibuprofen (to relieve pain).physical therapy, facial massage and acupuncture have also been used. last updated: 1/22/2016

MedlinePlus : 41 bell's palsy is the most common cause of facial paralysis. it usually affects just one side of the face. symptoms appear suddenly and are at their worst about 48 hours after they start. they can range from mild to severe and include twitching weakness paralysis drooping eyelid or corner of mouth drooling dry eye or mouth excessive tearing in the eye impaired ability to taste scientists think that a viral infection makes the facial nerve swell or become inflamed. you are most likely to get bell's palsy if you are pregnant, diabetic or sick with a cold or flu. three out of four patients improve without treatment. with or without treatment, most people begin to get better within 2 weeks and recover completely within 3 to 6 months. nih: national institute of neurological disorders and stroke

Wikipedia : 72 Bell\'s palsy is a type of facial paralysis that results in an inability to control the facial muscles... more...

Related Diseases for Bell's Palsy

Graphical network of the top 20 diseases related to Bell's Palsy:



Diseases related to Bell's Palsy

Symptoms & Phenotypes for Bell's Palsy

UMLS symptoms related to Bell's Palsy:


hemiplegia, ophthalmoplegia, oral manifestations, sciatica, facial paresis, facial palsy, upper motor neuron, facial palsy, lower motor neuron, hemifacial paralysis, back pain, headache, flaccid muscle tone, pain, seizures, syncope, tremor, chronic pain, muscle weakness, vertigo/dizziness, generalized muscle weakness, sleeplessness

Drugs & Therapeutics for Bell's Palsy

Drugs for Bell's Palsy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Antiemetics Phase 4,Phase 3
6 Anti-Inflammatory Agents Phase 4,Phase 3
7 Antineoplastic Agents, Hormonal Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 Gastrointestinal Agents Phase 4,Phase 3
10 glucocorticoids Phase 4,Phase 3
11 Hormone Antagonists Phase 4,Phase 3
12 Hormones Phase 4,Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
14 Methylprednisolone acetate Phase 4,Phase 3
15 Methylprednisolone Hemisuccinate Phase 4,Phase 3
16 Neuroprotective Agents Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Prednisolone acetate Phase 4,Phase 3
19 Prednisolone hemisuccinate Phase 4,Phase 3
20 Prednisolone phosphate Phase 4,Phase 3
21 Protective Agents Phase 4,Phase 3
22 Acyclovir Phase 4
23 Anti-Infective Agents Phase 4,Phase 3
24 Antiviral Agents Phase 4
25 valacyclovir Phase 4
26 abobotulinumtoxinA Phase 4
27 Botulinum Toxins Phase 4
28 Botulinum Toxins, Type A Phase 4
29 Cholinergic Agents Phase 4
30 incobotulinumtoxinA Phase 4
31 Neuromuscular Agents Phase 4
32 Neurotransmitter Agents Phase 4
33 onabotulinumtoxinA Phase 4
34 Vaccines Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Anti-Arrhythmia Agents Phase 4
38 Central Nervous System Depressants Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Sodium Channel Blockers Phase 4
41 alpha-methyltyrosine Phase 2
42
Prednisone Approved, Vet_approved 53-03-2 5865
43
Menthol Approved Early Phase 1 2216-51-5 16666
44
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
45
Salicylic acid Approved, Vet_approved 69-72-7 338
46 Antifungal Agents
47 Dermatologic Agents
48 Keratolytic Agents

Interventional clinical trials:

(show all 40)

id Name Status NCT ID Phase Drugs
1 Scandinavian Bell's Palsy Study Completed NCT00510263 Phase 4 Prednisolone + placebo;Valaciclovir + placebo;Prednisolone + valaciclovir;Placebo + placebo
2 Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis Completed NCT03048383 Phase 4 OnabotulinumtoxinA Injectable Product;AbobotulinumtoxinA Injectable Product;Incobotulinumtoxin A Injectable Product
3 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
4 Reinnervation of Facial Muscles After Lengthening Temporalis Myoplasty Terminated NCT01833221 Phase 4 injection of 1% lidocaine, 2mL for facial nerve block
5 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
6 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
7 Quadrant Versus Superficial Parotidectomy Withdrawn NCT01607866 Phase 2, Phase 3
8 Comparison of Antibiotic Therapy Alone or Combined With Corticosteroids for the Treatment of Nontuberculous Mycobacterial Cervicofacial Lymphadenitis in Children: A Randomized Double-Blind Placebo-Controlled Study Withdrawn NCT01614977 Phase 3 Methylprednisoline
9 Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome Terminated NCT01127503 Phase 2 Metyrosine;Placebo
10 The Relationship Between Psychological Factors and Bell's Palsy Unknown status NCT01377766
11 Prednisone and Acupuncture for the Treatment of Facial Neuritis: a Multiple Center, CER in China Unknown status NCT01201642 Prednisolone
12 A Clinical Study on the Combined Magnetic and Oxygen Treatment for Bell's Palsy Completed NCT01686464 prednisone and valacyclovir treatments
13 Acupuncture With Deqi And Psychological Effects in Treatment of Bell's Palsy Completed NCT00685789
14 Randomized Controlled Trial of Acupuncture to Treat Bell's Palsy According to Different Stages Completed NCT00608660
15 Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy Completed NCT00561106 prednisone- valacyclovir;prednisone-placebo
16 Steroid-Antiviral Treatment in Rehabilitation of Facial Palsy Completed NCT02328079 Steroids (Prednisolone) and Steroids plus Antiviral (Prednisolone + acyclovir)
17 Microbiologic Findings of Acute Facial Palsy in Children Completed NCT01537952
18 Anthropometric Angular Measurement to Determine Muscle Tonus in Patients With Peripheral Facial Paralysis Completed NCT00903669
19 Myofunctional Therapy in Facial Palsy Completed NCT00989209 Botulinum Toxin Type A
20 Assessment of the Cross-face Nerve Graft in the Treatment of Facial Paralysis Completed NCT03006783
21 Cognitive Function and Emotional Possessing in Bilateral Facial Palsy Completed NCT02179450
22 Study of a New Technique to Improve the Symptoms of Orofacial Discomfort in Patients With Peripheral Facial Paralysis Completed NCT01327157
23 Complications in Parotid Surgery Completed NCT02486393
24 Retrospective Clinical Outcome of Parotid Tumor Surgery Completed NCT01983176
25 Post-parotidectomy Facial Paresis: Intraoperative and Postoperative Factors Completed NCT02527226
26 Clinical Research Core Dental Screening Protocol Completed NCT00090818
27 Ultrasound Evaluation of Tongue Movements in Speech and Swallowing Completed NCT00001167
28 Morphometric Study of the Muscles of the Skin in MRI 3 Tesla in Patients With Facial Paralysis. Recruiting NCT03115203
29 The Role of a Device to Evaluate the Neuromuscular Function in Assessing Muscle in Facial Paralysis Patients Recruiting NCT02489162
30 The Prehospital Selection of Acute Stroke Patients Recruiting NCT03072524
31 Magnetic Correction of Eye Lid Paralysis Recruiting NCT02988856
32 Quantification, Analysis and Simulation of Facial Mimics Movements Recruiting NCT02002572
33 R. I. S. POS. T. A Recruiting NCT01991665
34 A Multicenter Study to Evaluate a Borrelia Diagnostic Test in Subjects With Early Stage or Late Stage Lyme Disease Recruiting NCT02741609
35 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
36 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Recruiting NCT02856958
37 Surgery or Clincial Follow up, in Patients With Bell' s Palsy Enrolling by invitation NCT02179684
38 Virtual Rehabilitation Program in Peripheral Facial Paralysis Not yet recruiting NCT02892864
39 Lengthening Temporalis Myoplasty and Improvement of Primary Swallowing Disorders in Facial Paralysis Not yet recruiting NCT03284125
40 Two Different Surgical Methods of Blepharospasm Not yet recruiting NCT02765113 Early Phase 1

Search NIH Clinical Center for Bell's Palsy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bell palsy

Genetic Tests for Bell's Palsy

Anatomical Context for Bell's Palsy

MalaCards organs/tissues related to Bell's Palsy:

39
Eye, Testes, Skin, Neutrophil, Tongue, Brain, Cortex

Publications for Bell's Palsy

Articles related to Bell's Palsy:

(show top 50) (show all 620)
id Title Authors Year
1
Management of Bell's palsy. ( 28798513 )
2017
2
Onset of bell's palsy in late pregnancy and early puerperium is associated with worse long-term outcomes. ( 28349542 )
2017
3
Role of low-level laser therapy added to facial expression exercises in patients with idiopathic facial (Bell's) palsy. ( 28337563 )
2017
4
Proposal of a Video-recording System for the Assessment of Bell's Palsy: Methodology and Preliminary Results. ( 28708795 )
2017
5
Bell's palsy: excluding serious illness in urgent and emergency care settings. ( 28403702 )
2017
6
Bell's palsy in children: Current treatment patterns in Australia and New Zealand. A PREDICT study. ( 28177168 )
2017
7
Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell's Palsy. ( 28299208 )
2017
8
Disrupted functional connectivity of striatal sub-regions in Bell's palsy patients. ( 28180070 )
2017
9
Bell's Palsy in Children (BellPIC): protocol for a multicentre, placebo-controlled randomized trial. ( 28193257 )
2017
10
Development of Bell's Palsy After Treatment With Ipilimumab and Nivolumab for Metastatic Melanoma: A Case Report. ( 28926356 )
2017
11
High-dose corticosteroids improve the prognosis of Bell's palsy compared with low-dose corticosteroids: A propensity score analysis. ( 28947095 )
2017
12
Prognostic factors of Bell's palsy and Ramsay Hunt syndrome. ( 28079835 )
2017
13
Effect of Age and Severity of Facial Palsy on Taste Thresholds in Bell's Palsy Patients. ( 28417103 )
2017
14
Oxidative Stress and Antioxidant Status in Patients with Bell's Palsy. ( 28680345 )
2017
15
Bell's palsy and influenza(H1N1)pdm09 containing vaccines: A self-controlled case series. ( 28467420 )
2017
16
Bidirectional association between Bell's palsy and anxiety disorders: A nationwide population-based retrospective cohort study. ( 28359982 )
2017
17
Bell's Palsy. ( 28375913 )
2017
18
Progression of Lyme disease to Bell's Palsy despite treatment with doxycycline. ( 28705754 )
2017
19
Concurrent pityriasis rosea and Bell's palsy. ( 28115404 )
2017
20
PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy. ( 28831749 )
2017
21
Lyme disease and Bell's palsy: an epidemiological study of diagnosis and risk in England. ( 28396367 )
2017
22
Benefits of High-dose Steroida88+a88Hespandera88+a88Mannitol Administration in the Treatment of Bell's Palsy. ( 28068304 )
2017
23
Invasive fungal rhinosinusitis presenting as Bell's palsy in a kidney and liver transplant recipient. ( 28495416 )
2017
24
A Case of Bell's Palsy with an Incidental Finding of a Cerebellopontine Angle Lipoma. ( 27733958 )
2016
25
Neutrophil to lymphocyte ratio in Bell's palsy. ( 27368462 )
2016
26
Kabat rehabilitation for Bell's palsy in the elderly. ( 27967288 )
2016
27
Association between recovery from Bell's palsy and body mass index. ( 27886463 )
2016
28
Needle Sensation and Personality Factors Influence Therapeutic Effect of Acupuncture for Treating Bell's Palsy: A Secondary Analysis of a Multicenter Randomized Controlled Trial. ( 27453226 )
2016
29
Prevalence of Bell's palsy in Qena Governorate, Egypt. ( 27238882 )
2016
30
High-frequency ultrasound as an adjunct to neural electrophysiology: Evaluation and prognosis of Bell's palsy. ( 26889221 )
2016
31
Functional Connectivity Modulation by Acupuncture in Patients with Bell's Palsy. ( 27293461 )
2016
32
Mandibular Canal Widening and Bell's Palsy: Sequelae of Perineural Invasion in Oral Cancer. ( 28025626 )
2016
33
Bell's palsy at high altitude -- an unsuspected finding. ( 27182447 )
2016
34
Facial nerve palsy including Bell's palsy: Case definitions and guidelines for collection, analysis, and presentation of immunisation safety data. ( 27235092 )
2016
35
Rhinoscintigraphic analysis of nasal mucociliary function in patients with Bell's palsy. ( 27022800 )
2016
36
Bell's palsy syndrome: mimics and chameleons. ( 27034243 )
2016
37
Bell's Palsy. ( 26611696 )
2016
38
Infections in the differential diagnosis of Bell's palsy: a plea for performing CSF analysis. ( 27530390 )
2016
39
Prognostic factors for recovery in Portuguese patients with Bell's palsy. ( 27426639 )
2016
40
The Effectiveness of Neural Therapy in Patients With Bell's Palsy. ( 27547166 )
2016
41
Efficacy of Low-Dose Corticosteroid Therapy Versus High-Dose Corticosteroid Therapy in Bell's Palsy in Children. ( 27686096 )
2016
42
Ocular vestibular evoked myogenic potential testing for the prognosis of Bell's palsy. ( 27609665 )
2016
43
Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker. ( 27383276 )
2016
44
Corticosteroids for Bell's palsy (idiopathic facial paralysis). ( 27428352 )
2016
45
Diagnostic and prognostic value of procalcitonin levels in patients with Bell's palsy. ( 26894418 )
2016
46
Steroid/Antiviral for the treatment of Bell's palsy: Double blind randomized clinical trial. ( 27689547 )
2016
47
Role of Kabat rehabilitation in facial nerve palsy: a randomised study on severe cases of Bell's palsy. ( 27734980 )
2016
48
Letter to the Editor concerning "New Predictive Parameters of Bell's Palsy: Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio". ( 27994931 )
2016
49
A general practice approach to Bell's palsy. ( 27806447 )
2016
50
Do Antiviral Medications Improve Symptoms in the Treatment of Bell's Palsy? ( 27350020 )
2016

Variations for Bell's Palsy

Expression for Bell's Palsy

Search GEO for disease gene expression data for Bell's Palsy.

Pathways for Bell's Palsy

GO Terms for Bell's Palsy

Cellular components related to Bell's Palsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 azurophil granule lumen GO:0035578 8.62 DEFA1 DEFA3

Biological processes related to Bell's Palsy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.5 DEFA1 DEFA3 MX1
2 defense response to Gram-positive bacterium GO:0050830 9.48 DEFA1 DEFA3
3 antimicrobial humoral response GO:0019730 9.46 DEFA1 DEFA3
4 killing of cells of other organism GO:0031640 9.43 DEFA1 DEFA3
5 antibacterial humoral response GO:0019731 9.4 DEFA1 DEFA3
6 defense response to fungus GO:0050832 9.37 DEFA1 DEFA3
7 innate immune response in mucosa GO:0002227 9.26 DEFA1 DEFA3
8 intracellular estrogen receptor signaling pathway GO:0030520 9.16 DEFA1 DEFA3
9 mitochondrial fission GO:0000266 8.96 MX1 PRKN
10 defense response GO:0006952 8.8 DEFA1 DEFA3 MX1

Sources for Bell's Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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