MCID: BNG025
MIFTS: 29

Benign Mammary Dysplasia malady

Reproductive diseases category

Summaries for Benign Mammary Dysplasia

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Fibrocystic breast or fibrocystic breast disease is a condition of breast tissue affecting an estimated... more...

MalaCards: Benign Mammary Dysplasia is related to breast fibroadenosis and fibrosclerosis of breast. An important gene associated with Benign Mammary Dysplasia is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are Wnt Signaling Pathway and Integrated Breast Cancer Pathway. The compounds sanguinarine and gossypol have been mentioned in the context of this disorder. Affiliated tissues include breast.

Aliases & Classifications for Benign Mammary Dysplasia

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8Disease Ontology, 60UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

benign mammary dysplasia 8 60


External Ids:

Disease Ontology8 DOID:9504
ICD9CM27 610.8
ICD1025 N60

Related Diseases for Benign Mammary Dysplasia

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Benign Mammary Dysplasia:



Diseases related to benign mammary dysplasia

Clinical Features for Benign Mammary Dysplasia

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Drugs & Therapeutics for Benign Mammary Dysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Benign Mammary Dysplasia

Drug clinical trials:

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Search NIH Clinical Center for Benign Mammary Dysplasia

Search CenterWatch for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

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Anatomical Context for Benign Mammary Dysplasia

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32MalaCards
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MalaCards organs/tissues related to Benign Mammary Dysplasia:

32
Breast

Animal Models for Benign Mammary Dysplasia or affiliated genes

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Publications for Benign Mammary Dysplasia

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50PubMed
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Articles related to Benign Mammary Dysplasia:

idTitleAuthorsYear
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. (15478112)
2004
2
Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. (2456993)
1988
3
Modern management of benign mammary dysplasia. (470733)
1979
4
Benign mammary dysplasia. (514166)
1979
5
Benign mammary dysplasia. (514167)
1979
6
Aspiration biopsy cytology in proliferating benign mammary dysplasia. (277037)
1978
7
Fibrocystic disease of the breast (benign mammary dysplasia). (1165420)
1975
8
Periductal foam cells in benign mammary dysplasia. (1195061)
1975
9
Neural invasion in benign mammary dysplasia. (4719773)
1973
10
Benign mammary dysplasia. (5073961)
1972

Genetic Variations for Benign Mammary Dysplasia

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Expression for genes affiliated with Benign Mammary Dysplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Mammary Dysplasia

Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for genes affiliated with Benign Mammary Dysplasia

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 55SinoBiological, 53Reactome, 52R&D Systems, 51QIAGEN, 12EMD Millipore
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Pathways related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1BCL2, BAK1
29.1BAK1, BCL2
39.1BCL2, BAK1
49.1BAK1, BCL2
59.1BAK1, BCL2
6
Hide members
9.1BCL2, BAK1
79.1BAK1, BCL2
8
Hide members
9.1BAK1, BCL2
9
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.1BAK1, BCL2
10
Hide members
9.1BCL2, BAK1
11
Hide members
9.1BAK1, BCL2
129.1BAK1, BCL2

Compounds for genes affiliated with Benign Mammary Dysplasia

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1sanguinarine449.5BAK1, BCL2
2gossypol449.5BCL2, BAK1
3chlorambucil44 1110.5BCL2, BAK1
4noxa449.5BCL2, BAK1
5dutp449.5BAK1, BCL2
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5BCL2, BAK1
7fludarabine44 1110.5BAK1, BCL2
8flavopiridol44 1110.5BAK1, BCL2
9celecoxib44 59 28 49 11 2414.5BCL2, BAK1
10bortezomib44 1110.5BCL2, BAK1
11adpribose449.5BCL2, BAK1
12resveratrol44 59 11 2412.5BCL2, BAK1
13troglitazone44 28 59 1112.4BCL2, BAK1
14docetaxel44 49 59 1112.4BAK1, BCL2
15camptothecin44 59 1111.4BAK1, BCL2
16quercetin44 59 11 2412.4BAK1, BCL2
17curcumin449.4BAK1, BCL2
18thapsigargin44 5910.4BCL2, BAK1
19ceramide449.4BCL2, BAK1
20phosphatidylserine44 28 1111.4BAK1, BCL2
215fluorouracil449.3BCL2, BAK1
22retinoid449.3BCL2, BAK1
23etoposide44 49 59 1112.3BCL2, BAK1
24butyrate449.2BCL2, BAK1
25paclitaxel44 49 1111.2BCL2, BAK1
26doxorubicin44 49 1111.1BCL2, BAK1
27cisplatin44 49 59 1112.1BCL2, BAK1
28actinomycin d449.0BAK1, BCL2
29paraffin448.8BAK1, BCL2

GO Terms for genes affiliated with Benign Mammary Dysplasia

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Sources:
16Gene Ontology
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Cellular components related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial outer membraneGO:0057419.1BCL2, BAK1
2pore complexGO:0469308.8BCL2, BAK1

Biological processes related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein homodimerization activityGO:0434969.4BAK1, BCL2
2regulation of protein heterodimerization activityGO:0434979.4BAK1, BCL2
3regulation of mitochondrial membrane permeabilityGO:0469029.3BAK1, BCL2
4regulation of mitochondrial membrane potentialGO:0518819.3BAK1, BCL2
5B cell homeostasisGO:0017829.3BCL2, BAK1
6intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.2BAK1, BCL2
7release of cytochrome c from mitochondriaGO:0018369.2BAK1, BCL2
8response to gamma radiationGO:0103329.1BAK1, BCL2
9response to drugGO:0424939.1BCL2, BAK1
10response to hydrogen peroxideGO:0425429.0BAK1, BCL2
11intrinsic apoptotic signaling pathwayGO:0971938.8BCL2, BAK1

Molecular functions related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428029.1BCL2, BAK1
2protein heterodimerization activityGO:0469828.8BCL2, BAK1

Products for genes affiliated with Benign Mammary Dysplasia

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Sources for Benign Mammary Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet