MCID: BNG025
MIFTS: 27

Benign Mammary Dysplasia malady

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Benign Mammary Dysplasia

Aliases & Descriptions for Benign Mammary Dysplasia:

Name: Benign Mammary Dysplasia 12 69

Classifications:



External Ids:

Disease Ontology 12 DOID:9504
ICD9CM 35 610.8
ICD10 33 N60
UMLS 69 C0156319

Summaries for Benign Mammary Dysplasia

MalaCards based summary : Benign Mammary Dysplasia is related to solitary cyst of breast and breast fibroadenosis. An important gene associated with Benign Mammary Dysplasia is BCL2 (BCL2, Apoptosis Regulator), and among its related pathways/superpathways are TNFR1 Pathway and Apoptosis Modulation and Signaling. The drugs Tamoxifen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include breast.

Related Diseases for Benign Mammary Dysplasia

Diseases related to Benign Mammary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 solitary cyst of breast 10.3
2 breast fibroadenosis 10.3
3 fibrosclerosis of breast 10.3
4 breast cyst 10.1
5 lassa fever 9.8 BAK1 BCL2
6 breast cancer 9.7

Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to Benign Mammary Dysplasia

Symptoms & Phenotypes for Benign Mammary Dysplasia

Drugs & Therapeutics for Benign Mammary Dysplasia

Drugs for Benign Mammary Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tamoxifen Approved Phase 4 10540-29-1 2733526
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antimetabolites Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Antirheumatic Agents Phase 4
9 Bone Density Conservation Agents Phase 4
10 Dermatologic Agents Phase 4
11 Efamol Phase 4
12 Estrogen Antagonists Phase 4
13 Estrogen Receptor Modulators Phase 4
14 Estrogens Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Hypolipidemic Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Selective Estrogen Receptor Modulators Phase 4
22 Evening Primrose Nutraceutical Phase 4
23 Omega 3 Fatty Acid Nutraceutical Phase 2
24
Ethanol Approved 64-17-5 702
25
Progesterone Approved, Vet_approved 57-83-0 5994
26
Zinc Approved 7440-66-6 32051 23994
27
Cholecalciferol Approved, Nutraceutical 67-97-0 6221 10883523 5280795
28
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
29
Iodine 7553-56-2 807
30 Antibodies
31 Immunoglobulins
32 Ergocalciferols
33 Micronutrients
34 Trace Elements
35 vitamin d
36 Vitamins
37 Calciferol Nutraceutical
38 Vitamin D2 Nutraceutical

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Effects of Tamoxifen in Premenopausal Women With Benign Breast Disease Not at High-Risk of Developing Breast Cancer Completed NCT00999921 Phase 4
2 Diet and Breast Cancer Prevention Trial Completed NCT00148057 Phase 3
3 Docosahexaenoic Acid in Preventing Recurrence in Breast Cancer Survivors Active, not recruiting NCT01849250 Phase 2
4 China CellSearch Study Unknown status NCT01116869
5 Clinical Trial of Quantitative Detection Kit for Hsp90α in Breast Cancer Unknown status NCT02324101
6 Women At Risk: The High Risk Breast Cancer Program Unknown status NCT01034891
7 Prolactin Receptor and Breast Diseases Completed NCT00842465
8 Genetics of Mammographic Appearances and Patterns (The GenMap Study) Completed NCT01160510
9 Nuclear Morphology of Breast Cells in Ductal Lavage Completed NCT00259597
10 The Ghana Breast Health Study Completed NCT01661023
11 Markers for Breast Cancer Completed NCT00339248
12 Breast Cancer, Breast Disease, and Pesticides Completed NCT00341315
13 The Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA-15-3 is a Reliable Biomarker of Breast Cancer Completed NCT01643148
14 A Comparison of Breast Tomosynthesis Mammography and Conventional Breast Imaging in the Characterization of Breast Masses Completed NCT00826488 Early Phase 1
15 Study of Urine Samples From Women With Newly Diagnosed Breast Cancer Enrolled on Clinical Trial UNMC-08105 Completed NCT00959244
16 Comparison of MRI and Molecular Breast Imaging in Breast Diagnostic Evaluation Completed NCT00591864
17 Johns Hopkins Breast Cancer Program Longitudinal Repository Recruiting NCT01937039
18 Diagnostic Performance of an Automated Breast Ultrasound System (ABUS) Recruiting NCT02661204
19 Studying Blood and Tumor Tissue Samples in Women With Invasive Breast Cancer, Ductal or Lobular Carcinoma in Situ, or Benign Breast Disease Active, not recruiting NCT00898508
20 VITamin D and OmegA-3 TriaL: Effects on Mammographic Density and Breast Tissue Enrolling by invitation NCT02239874
21 Cystic Breast Masses by Contrast Enhanced Ultrasound (CEUS) Not yet recruiting NCT02887937
22 Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease Terminated NCT00813878

Search NIH Clinical Center for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

Anatomical Context for Benign Mammary Dysplasia

MalaCards organs/tissues related to Benign Mammary Dysplasia:

39
Breast

Publications for Benign Mammary Dysplasia

Articles related to Benign Mammary Dysplasia:

id Title Authors Year
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. ( 15478112 )
2004
2
Benign mammary dysplasia. ( 514166 )
1979
3
Benign mammary dysplasia. ( 514167 )
1979
4
Modern management of benign mammary dysplasia. ( 470733 )
1979
5
Aspiration biopsy cytology in proliferating benign mammary dysplasia. ( 277037 )
1978
6
Fibrocystic disease of the breast (benign mammary dysplasia). ( 1165420 )
1975
7
Periductal foam cells in benign mammary dysplasia. ( 1195061 )
1975
8
Neural invasion in benign mammary dysplasia. ( 4719773 )
1973
9
Benign mammary dysplasia. ( 5073961 )
1972

Variations for Benign Mammary Dysplasia

Expression for Benign Mammary Dysplasia

Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for Benign Mammary Dysplasia

Pathways related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 BAK1 BCL2
2
Show member pathways
12.26 BAK1 BCL2
3 12.01 BAK1 BCL2
4 11.79 BAK1 BCL2
5 11.73 BAK1 BCL2
6 11.68 BAK1 BCL2
7 11.61 BAK1 BCL2
8 11.58 BAK1 BCL2
9
Show member pathways
11.53 BAK1 BCL2
10 11.46 BAK1 BCL2
11
Show member pathways
11.29 BAK1 BCL2
12 11.18 BAK1 BCL2
13 10.86 BAK1 BCL2
14
Show member pathways
10.81 BAK1 BCL2
15 10.32 BAK1 BCL2

GO Terms for Benign Mammary Dysplasia

Cellular components related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrial outer membrane GO:0005741 9.16 BAK1 BCL2
2 mitochondrial membrane GO:0031966 8.96 BAK1 BCL2
3 pore complex GO:0046930 8.62 BAK1 BCL2

Biological processes related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.56 BAK1 BCL2
2 cell proliferation GO:0008283 9.55 BAK1 BCL2
3 response to drug GO:0042493 9.54 BAK1 BCL2
4 regulation of apoptotic process GO:0042981 9.52 BAK1 BCL2
5 regulation of cell cycle GO:0051726 9.51 BAK1 BCL2
6 response to hydrogen peroxide GO:0042542 9.49 BAK1 BCL2
7 response to gamma radiation GO:0010332 9.48 BAK1 BCL2
8 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.46 BAK1 BCL2
9 regulation of mitochondrial membrane potential GO:0051881 9.43 BAK1 BCL2
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.4 BAK1 BCL2
11 release of cytochrome c from mitochondria GO:0001836 9.37 BAK1 BCL2
12 B cell homeostasis GO:0001782 9.32 BAK1 BCL2
13 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.26 BAK1 BCL2
14 regulation of mitochondrial membrane permeability GO:0046902 9.16 BAK1 BCL2
15 regulation of protein heterodimerization activity GO:0043497 8.96 BAK1 BCL2
16 regulation of protein homodimerization activity GO:0043496 8.62 BAK1 BCL2

Molecular functions related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.62 BAK1 BCL2

Sources for Benign Mammary Dysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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