MCID: BNG025
MIFTS: 26

Benign Mammary Dysplasia malady

Reproductive diseases category

Summaries for Benign Mammary Dysplasia

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MalaCards based summary: Benign Mammary Dysplasia is related to breast cancer and breast fibroadenosis. An important gene associated with Benign Mammary Dysplasia is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are TWEAK Pathway and Apoptosis and Autophagy. The compounds sanguinarine and gossypol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Benign Mammary Dysplasia

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Benign Mammary Dysplasia, Aliases & Descriptions:

Name: Benign Mammary Dysplasia 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology9 DOID:9504
ICD9CM27 610.8
ICD1025 N60

Related Diseases for Benign Mammary Dysplasia

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Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to benign mammary dysplasia

Symptoms for Benign Mammary Dysplasia

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Drugs & Therapeutics for Benign Mammary Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Benign Mammary Dysplasia

Search NIH Clinical Center for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

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Anatomical Context for Benign Mammary Dysplasia

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MalaCards organs/tissues related to Benign Mammary Dysplasia:

31
Breast

Animal Models for Benign Mammary Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Benign Mammary Dysplasia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BAK1, BCL2

Publications for Benign Mammary Dysplasia

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Articles related to Benign Mammary Dysplasia:

idTitleAuthorsYear
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. (15478112)
2004
2
Modern management of benign mammary dysplasia. (470733)
1979
3
Benign mammary dysplasia. (514166)
1979
4
Benign mammary dysplasia. (514167)
1979
5
Aspiration biopsy cytology in proliferating benign mammary dysplasia. (277037)
1978
6
Fibrocystic disease of the breast (benign mammary dysplasia). (1165420)
1975
7
Periductal foam cells in benign mammary dysplasia. (1195061)
1975
8
Neural invasion in benign mammary dysplasia. (4719773)
1973
9
Benign mammary dysplasia. (5073961)
1972

Variations for Benign Mammary Dysplasia

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Expression for genes affiliated with Benign Mammary Dysplasia

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Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for genes affiliated with Benign Mammary Dysplasia

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Pathways related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.1BAK1, BCL2
29.1BAK1, BCL2
39.1BCL2, BAK1
49.1BAK1, BCL2
5
Show member pathways
9.1BAK1, BCL2
6
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
9.1BAK1, BCL2
7
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.1BAK1, BCL2
8
Show member pathways
9.1BCL2, BAK1
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.1BAK1, BCL2
10
Show member pathways
9.1BAK1, BCL2
11
Show member pathways
9.1BCL2, BAK1
12
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1BAK1, BCL2
139.1BAK1, BCL2
149.1BAK1, BCL2
15
Show member pathways
9.1BAK1, BCL2

Compounds for genes affiliated with Benign Mammary Dysplasia

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Compounds related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sanguinarine439.5BAK1, BCL2
2gossypol439.5BAK1, BCL2
3chlorambucil43 1210.5BCL2, BAK1
4noxa439.5BAK1, BCL2
5dutp439.5BCL2, BAK1
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.5BCL2, BAK1
7fludarabine43 49 1211.5BAK1, BCL2
8flavopiridol43 1210.5BAK1, BCL2
9celecoxib43 59 28 49 24 1214.5BCL2, BAK1
10bortezomib43 49 1211.5BAK1, BCL2
11adpribose439.5BAK1, BCL2
12resveratrol43 59 24 1212.5BAK1, BCL2
13troglitazone43 28 59 1212.5BCL2, BAK1
14camptothecin43 59 1211.5BAK1, BCL2
15docetaxel43 49 59 1212.5BAK1, BCL2
16quercetin43 59 24 1212.5BAK1, BCL2
17curcumin439.4BCL2, BAK1
18thapsigargin43 5910.4BAK1, BCL2
19ceramide439.4BAK1, BCL2
20phosphatidylserine43 28 1211.4BAK1, BCL2
215fluorouracil439.4BCL2, BAK1
22retinoid439.4BAK1, BCL2
23etoposide43 49 59 1212.4BAK1, BCL2
24butyrate439.4BAK1, BCL2
25paclitaxel43 49 1211.3BCL2, BAK1
26doxorubicin43 49 1211.3BAK1, BCL2
27actinomycin d439.3BAK1, BCL2
28paraffin439.2BAK1, BCL2
29cisplatin43 49 59 1212.2BCL2, BAK1
30cycloheximide439.1BAK1, BCL2
31phosphatidylinositol439.1BAK1, BCL2
32h2o2439.0BAK1, BCL2
33dexamethasone43 49 28 1211.8BAK1, BCL2

GO Terms for genes affiliated with Benign Mammary Dysplasia

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Cellular components related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:00057839.1BAK1, BCL2
2pore complexGO:00469309.0BAK1, BCL2
3mitochondrial outer membraneGO:00057418.8BAK1, BCL2

Biological processes related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein homodimerization activityGO:00434969.4BAK1, BCL2
2regulation of protein heterodimerization activityGO:00434979.4BAK1, BCL2
3endoplasmic reticulum calcium ion homeostasisGO:00324699.4BAK1, BCL2
4regulation of mitochondrial membrane permeabilityGO:00469029.4BCL2, BAK1
5B cell homeostasisGO:00017829.4BAK1, BCL2
6regulation of mitochondrial membrane potentialGO:00518819.4BAK1, BCL2
7intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:00700599.3BAK1, BCL2
8release of cytochrome c from mitochondriaGO:00018369.3BCL2, BAK1
9response to gamma radiationGO:00103329.3BAK1, BCL2
10extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.2BAK1, BCL2
11response to hydrogen peroxideGO:00425429.2BAK1, BCL2
12intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.1BCL2, BAK1
13apoptotic processGO:00069159.1BAK1, BCL2
14intrinsic apoptotic signaling pathwayGO:00971939.0BAK1, BCL2
15response to drugGO:00424938.8BAK1, BCL2

Molecular functions related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428039.1BAK1, BCL2
2protein heterodimerization activityGO:00469829.0BAK1, BCL2
3identical protein bindingGO:00428028.8BAK1, BCL2

Products for genes affiliated with Benign Mammary Dysplasia

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  • Antibodies
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Sources for Benign Mammary Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet