MCID: BNG025
MIFTS: 33

Benign Mammary Dysplasia malady

Reproductive diseases, Cancer diseases categories
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Summaries for Benign Mammary Dysplasia

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Fibrocystic breast or fibrocystic breast disease is a condition of breast tissue affecting an estimated... more...

MalaCards: Benign Mammary Dysplasia is related to breast cancer and breast fibroadenosis. An important gene associated with Benign Mammary Dysplasia is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are TWEAK Pathway and Apoptosis and Autophagy. The compounds sanguinarine and gossypol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Benign Mammary Dysplasia

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8Disease Ontology, 62UMLS, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

benign mammary dysplasia 8 62


External Ids:

Disease Ontology8 DOID:9504
ICD9CM27 610.8
ICD1025 N60

Related Diseases for Benign Mammary Dysplasia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to benign mammary dysplasia

Symptoms for Benign Mammary Dysplasia

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Drugs & Therapeutics for Benign Mammary Dysplasia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Benign Mammary Dysplasia

Search NIH Clinical Center for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

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Anatomical Context for Benign Mammary Dysplasia

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33MalaCards
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MalaCards organs/tissues related to Benign Mammary Dysplasia:

33
Breast

Animal Models for Benign Mammary Dysplasia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Benign Mammary Dysplasia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BAK1, BCL2

Publications for Benign Mammary Dysplasia

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52PubMed
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Articles related to Benign Mammary Dysplasia:

idTitleAuthorsYear
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. (15478112)
2004
2
Modern management of benign mammary dysplasia. (470733)
1979
3
Benign mammary dysplasia. (514166)
1979
4
Benign mammary dysplasia. (514167)
1979
5
Aspiration biopsy cytology in proliferating benign mammary dysplasia. (277037)
1978
6
Fibrocystic disease of the breast (benign mammary dysplasia). (1165420)
1975
7
Periductal foam cells in benign mammary dysplasia. (1195061)
1975
8
Neural invasion in benign mammary dysplasia. (4719773)
1973
9
Benign mammary dysplasia. (5073961)
1972

Variations for Benign Mammary Dysplasia

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Expression for genes affiliated with Benign Mammary Dysplasia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Mammary Dysplasia

Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for genes affiliated with Benign Mammary Dysplasia

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Sources:
50PathCards, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 30KEGG, 57SinoBiological, 54R&D Systems
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Pathways related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.1BAK1, BCL2
29.1BAK1, BCL2
39.1BCL2, BAK1
49.1BAK1, BCL2
5
Show member pathways
9.1BAK1, BCL2
6
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
9.1BAK1, BCL2
7
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.1BAK1, BCL2
8
Show member pathways
9.1BCL2, BAK1
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.1BAK1, BCL2
10
Show member pathways
9.1BAK1, BCL2
11
Show member pathways
9.1BCL2, BAK1
12
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.1BAK1, BCL2
139.1BAK1, BCL2
149.1BAK1, BCL2
15
Show member pathways
9.1BAK1, BCL2

Compounds for genes affiliated with Benign Mammary Dysplasia

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sanguinarine459.5BAK1, BCL2
2gossypol459.5BAK1, BCL2
3chlorambucil45 1110.5BCL2, BAK1
4noxa459.5BAK1, BCL2
5dutp459.5BCL2, BAK1
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5BCL2, BAK1
7fludarabine45 51 1111.5BAK1, BCL2
8flavopiridol45 1110.5BAK1, BCL2
9celecoxib45 61 29 51 24 1114.5BCL2, BAK1
10bortezomib45 51 1111.5BAK1, BCL2
11adpribose459.5BAK1, BCL2
12resveratrol45 61 24 1112.5BAK1, BCL2
13troglitazone45 29 61 1112.5BCL2, BAK1
14camptothecin45 61 1111.5BAK1, BCL2
15docetaxel45 51 61 1112.5BAK1, BCL2
16quercetin45 61 24 1112.5BAK1, BCL2
17curcumin459.4BCL2, BAK1
18thapsigargin45 6110.4BAK1, BCL2
19ceramide459.4BAK1, BCL2
20phosphatidylserine45 29 1111.4BAK1, BCL2
215fluorouracil459.4BCL2, BAK1
22retinoid459.4BAK1, BCL2
23etoposide45 51 61 1112.4BAK1, BCL2
24butyrate459.4BAK1, BCL2
25paclitaxel45 51 1111.3BCL2, BAK1
26doxorubicin45 51 1111.3BAK1, BCL2
27actinomycin d459.3BAK1, BCL2
28paraffin459.2BAK1, BCL2
29cisplatin45 51 61 1112.2BCL2, BAK1
30cycloheximide459.1BAK1, BCL2
31phosphatidylinositol459.1BAK1, BCL2
32h2o2459.0BAK1, BCL2
33dexamethasone45 51 29 1111.8BAK1, BCL2

GO Terms for genes affiliated with Benign Mammary Dysplasia

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16Gene Ontology
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Cellular components related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.1BAK1, BCL2
2pore complexGO:0469309.0BAK1, BCL2
3mitochondrial outer membraneGO:0057418.8BAK1, BCL2

Biological processes related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein homodimerization activityGO:0434969.4BAK1, BCL2
2regulation of protein heterodimerization activityGO:0434979.4BAK1, BCL2
3endoplasmic reticulum calcium ion homeostasisGO:0324699.4BAK1, BCL2
4regulation of mitochondrial membrane permeabilityGO:0469029.4BCL2, BAK1
5B cell homeostasisGO:0017829.4BAK1, BCL2
6regulation of mitochondrial membrane potentialGO:0518819.4BAK1, BCL2
7intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.3BAK1, BCL2
8release of cytochrome c from mitochondriaGO:0018369.3BCL2, BAK1
9response to gamma radiationGO:0103329.3BAK1, BCL2
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.2BAK1, BCL2
11response to hydrogen peroxideGO:0425429.2BAK1, BCL2
12intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1BCL2, BAK1
13apoptotic processGO:0069159.1BAK1, BCL2
14intrinsic apoptotic signaling pathwayGO:0971939.0BAK1, BCL2
15response to drugGO:0424938.8BAK1, BCL2

Molecular functions related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1BAK1, BCL2
2protein heterodimerization activityGO:0469829.0BAK1, BCL2
3identical protein bindingGO:0428028.8BAK1, BCL2

Products for genes affiliated with Benign Mammary Dysplasia

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Sources for Benign Mammary Dysplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet