MCID: BNG025
MIFTS: 26

Benign Mammary Dysplasia malady

Reproductive diseases category

Aliases & Classifications for Benign Mammary Dysplasia

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Aliases & Descriptions for Benign Mammary Dysplasia:

Name: Benign Mammary Dysplasia 8 61


Classifications:



External Ids:

Disease Ontology8 DOID:9504
ICD9CM27 610.8
ICD1025 N60

Summaries for Benign Mammary Dysplasia

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MalaCards based summary: Benign Mammary Dysplasia is related to breast cancer and breast fibroadenosis. An important gene associated with Benign Mammary Dysplasia is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are TWEAK Pathway and Apoptosis and Autophagy. The compounds sanguinarine and gossypol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype hearing/vestibular/ear.

Related Diseases for Benign Mammary Dysplasia

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Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to benign mammary dysplasia

Symptoms for Benign Mammary Dysplasia

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Drugs & Therapeutics for Benign Mammary Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Benign Mammary Dysplasia

Search NIH Clinical Center for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

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Anatomical Context for Benign Mammary Dysplasia

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MalaCards organs/tissues related to Benign Mammary Dysplasia:

31
Breast

Animal Models for Benign Mammary Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Benign Mammary Dysplasia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BAK1, BCL2

Publications for Benign Mammary Dysplasia

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Articles related to Benign Mammary Dysplasia:

idTitleAuthorsYear
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. (15478112)
2004
2
Modern management of benign mammary dysplasia. (470733)
1979
3
Benign mammary dysplasia. (514166)
1979
4
Benign mammary dysplasia. (514167)
1979
5
Aspiration biopsy cytology in proliferating benign mammary dysplasia. (277037)
1978
6
Fibrocystic disease of the breast (benign mammary dysplasia). (1165420)
1975
7
Periductal foam cells in benign mammary dysplasia. (1195061)
1975
8
Neural invasion in benign mammary dysplasia. (4719773)
1973
9
Benign mammary dysplasia. (5073961)
1972

Variations for Benign Mammary Dysplasia

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Expression for genes affiliated with Benign Mammary Dysplasia

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Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for genes affiliated with Benign Mammary Dysplasia

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Pathways related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.1BAK1, BCL2
29.1BAK1, BCL2
39.1BCL2, BAK1
49.1BAK1, BCL2
5
Show member pathways
9.1BAK1, BCL2
6
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
9.1BAK1, BCL2
7
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.1BAK1, BCL2
8
Show member pathways
9.1BCL2, BAK1
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways59
9.1BAK1, BCL2
10
Show member pathways
9.1BAK1, BCL2
11
Show member pathways
9.1BCL2, BAK1
12
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.1BAK1, BCL2
139.1BAK1, BCL2
149.1BAK1, BCL2
15
Show member pathways
9.1BAK1, BCL2

Compounds for genes affiliated with Benign Mammary Dysplasia

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Compounds related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sanguinarine449.5BCL2, BAK1
2gossypol449.5BAK1, BCL2
3chlorambucil44 1110.5BAK1, BCL2
4noxa449.5BCL2, BAK1
5dutp449.5BAK1, BCL2
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5BCL2, BAK1
7fludarabine44 50 1111.5BAK1, BCL2
8flavopiridol44 1110.5BCL2, BAK1
9celecoxib44 60 28 50 24 1114.5BAK1, BCL2
10bortezomib44 50 1111.5BAK1, BCL2
11adpribose449.5BCL2, BAK1
12resveratrol44 60 24 1112.5BAK1, BCL2
13troglitazone44 28 60 1112.5BAK1, BCL2
14camptothecin44 60 1111.5BAK1, BCL2
15docetaxel44 50 60 1112.5BCL2, BAK1
16quercetin44 60 24 1112.5BCL2, BAK1
17curcumin449.4BAK1, BCL2
18thapsigargin44 6010.4BAK1, BCL2
19ceramide449.4BCL2, BAK1
20phosphatidylserine44 28 1111.4BCL2, BAK1
215fluorouracil449.4BCL2, BAK1
22retinoid449.4BCL2, BAK1
23etoposide44 50 60 1112.4BCL2, BAK1
24butyrate449.4BAK1, BCL2
25paclitaxel44 50 1111.3BCL2, BAK1
26doxorubicin44 50 1111.3BCL2, BAK1
27actinomycin d449.3BAK1, BCL2
28paraffin449.2BAK1, BCL2
29cisplatin44 50 60 1112.2BCL2, BAK1
30cycloheximide449.1BAK1, BCL2
31phosphatidylinositol449.1BCL2, BAK1
32h2o2449.0BAK1, BCL2
33dexamethasone44 50 28 1111.8BCL2, BAK1

GO Terms for genes affiliated with Benign Mammary Dysplasia

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Cellular components related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:00057839.1BAK1, BCL2
2pore complexGO:00469309.0BAK1, BCL2
3mitochondrial outer membraneGO:00057418.8BAK1, BCL2

Biological processes related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein homodimerization activityGO:00434969.4BAK1, BCL2
2regulation of protein heterodimerization activityGO:00434979.4BAK1, BCL2
3endoplasmic reticulum calcium ion homeostasisGO:00324699.4BAK1, BCL2
4regulation of mitochondrial membrane permeabilityGO:00469029.4BCL2, BAK1
5B cell homeostasisGO:00017829.4BAK1, BCL2
6regulation of mitochondrial membrane potentialGO:00518819.4BAK1, BCL2
7intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:00700599.3BAK1, BCL2
8release of cytochrome c from mitochondriaGO:00018369.3BCL2, BAK1
9response to gamma radiationGO:00103329.3BAK1, BCL2
10extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.2BAK1, BCL2
11response to hydrogen peroxideGO:00425429.2BAK1, BCL2
12intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.1BCL2, BAK1
13apoptotic processGO:00069159.1BAK1, BCL2
14intrinsic apoptotic signaling pathwayGO:00971939.0BAK1, BCL2
15response to drugGO:00424938.8BAK1, BCL2

Molecular functions related to Benign Mammary Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:00428039.1BAK1, BCL2
2protein heterodimerization activityGO:00469829.0BAK1, BCL2
3identical protein bindingGO:00428028.8BAK1, BCL2

Sources for Benign Mammary Dysplasia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet