MCID: BNG025
MIFTS: 33

Benign Mammary Dysplasia malady

Reproductive diseases, Cancer diseases categories

Summaries for Benign Mammary Dysplasia

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Sources:
66Wikipedia, 34MalaCards
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Wikipedia:66 Fibrocystic breast or fibrocystic breast disease is a condition of breast tissue affecting an estimated... more...

MalaCards: Benign Mammary Dysplasia is related to breast cancer and breast fibroadenosis. An important gene associated with Benign Mammary Dysplasia is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are TWEAK Pathway and Apoptosis and Autophagy. The compounds sanguinarine and gossypol have been mentioned in the context of this disorder. Affiliated tissues include breast, and related mouse phenotype hearing/vestibular/ear.

Aliases & Classifications for Benign Mammary Dysplasia

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9Disease Ontology, 63UMLS, 28ICD9CM, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Reproductive diseases


Aliases & Descriptions:

benign mammary dysplasia 9 63


External Ids:

Disease Ontology9 DOID:9504
ICD9CM28 610.8
ICD1026 N60

Related Diseases for Benign Mammary Dysplasia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Benign Mammary Dysplasia:



Diseases related to benign mammary dysplasia

Symptoms for Benign Mammary Dysplasia

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Drugs & Therapeutics for Benign Mammary Dysplasia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Benign Mammary Dysplasia

Drug clinical trials:

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Search NIH Clinical Center for Benign Mammary Dysplasia

Search CenterWatch for Benign Mammary Dysplasia

Genetic Tests for Benign Mammary Dysplasia

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Anatomical Context for Benign Mammary Dysplasia

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34MalaCards
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MalaCards organs/tissues related to Benign Mammary Dysplasia:

34
Breast

Animal Models for Benign Mammary Dysplasia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Benign Mammary Dysplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1BAK1, BCL2

Publications for Benign Mammary Dysplasia

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53PubMed
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Articles related to Benign Mammary Dysplasia:

idTitleAuthorsYear
1
Expression of the apoptotic markers in normal breast epithelium, benign mammary dysplasia and in breast cancer. (15478112)
2004
2
Modern management of benign mammary dysplasia. (470733)
1979
3
Benign mammary dysplasia. (514166)
1979
4
Benign mammary dysplasia. (514167)
1979
5
Aspiration biopsy cytology in proliferating benign mammary dysplasia. (277037)
1978
6
Fibrocystic disease of the breast (benign mammary dysplasia). (1165420)
1975
7
Periductal foam cells in benign mammary dysplasia. (1195061)
1975
8
Neural invasion in benign mammary dysplasia. (4719773)
1973
9
Benign mammary dysplasia. (5073961)
1972

Variations for Benign Mammary Dysplasia

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Expression for genes affiliated with Benign Mammary Dysplasia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Benign Mammary Dysplasia

Search GEO for disease gene expression data for Benign Mammary Dysplasia.

Pathways for genes affiliated with Benign Mammary Dysplasia

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 31KEGG, 58SinoBiological, 55R&D Systems
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Pathways related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
9.1BAK1, BCL2
29.1BAK1, BCL2
39.1BCL2, BAK1
49.1BAK1, BCL2
5
Show member pathways
9.1BAK1, BCL2
6
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
9.1BAK1, BCL2
7
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.1BAK1, BCL2
8
Show member pathways
9.1BCL2, BAK1
9
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways61
9.1BAK1, BCL2
10
Show member pathways
9.1BAK1, BCL2
11
Show member pathways
9.1BCL2, BAK1
12
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.1BAK1, BCL2
139.1BAK1, BCL2
149.1BAK1, BCL2
15
Show member pathways
9.1BAK1, BCL2

Compounds for genes affiliated with Benign Mammary Dysplasia

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 25HMDB
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Compounds related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1sanguinarine469.5BAK1, BCL2
2gossypol469.5BAK1, BCL2
3chlorambucil46 1210.5BCL2, BAK1
4noxa469.5BAK1, BCL2
5dutp469.5BCL2, BAK1
63-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.5BCL2, BAK1
7fludarabine46 52 1211.5BAK1, BCL2
8flavopiridol46 1210.5BAK1, BCL2
9celecoxib46 62 30 52 25 1214.5BCL2, BAK1
10bortezomib46 52 1211.5BAK1, BCL2
11adpribose469.5BAK1, BCL2
12resveratrol46 62 25 1212.5BAK1, BCL2
13troglitazone46 30 62 1212.5BCL2, BAK1
14camptothecin46 62 1211.5BAK1, BCL2
15docetaxel46 52 62 1212.5BAK1, BCL2
16quercetin46 62 25 1212.5BAK1, BCL2
17curcumin469.4BCL2, BAK1
18thapsigargin46 6210.4BAK1, BCL2
19ceramide469.4BAK1, BCL2
20phosphatidylserine46 30 1211.4BAK1, BCL2
215fluorouracil469.4BCL2, BAK1
22retinoid469.4BAK1, BCL2
23etoposide46 52 62 1212.4BAK1, BCL2
24butyrate469.4BAK1, BCL2
25paclitaxel46 52 1211.3BCL2, BAK1
26doxorubicin46 52 1211.3BAK1, BCL2
27actinomycin d469.3BAK1, BCL2
28paraffin469.2BAK1, BCL2
29cisplatin46 52 62 1212.2BCL2, BAK1
30cycloheximide469.1BAK1, BCL2
31phosphatidylinositol469.1BAK1, BCL2
32h2o2469.0BAK1, BCL2
33dexamethasone46 52 30 1211.8BAK1, BCL2

GO Terms for genes affiliated with Benign Mammary Dysplasia

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Sources:
17Gene Ontology
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Cellular components related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulumGO:0057839.1BAK1, BCL2
2pore complexGO:0469309.0BAK1, BCL2
3mitochondrial outer membraneGO:0057418.8BAK1, BCL2

Biological processes related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of protein homodimerization activityGO:0434969.4BAK1, BCL2
2regulation of protein heterodimerization activityGO:0434979.4BAK1, BCL2
3endoplasmic reticulum calcium ion homeostasisGO:0324699.4BAK1, BCL2
4regulation of mitochondrial membrane permeabilityGO:0469029.4BCL2, BAK1
5B cell homeostasisGO:0017829.4BAK1, BCL2
6regulation of mitochondrial membrane potentialGO:0518819.4BAK1, BCL2
7intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0700599.3BAK1, BCL2
8release of cytochrome c from mitochondriaGO:0018369.3BCL2, BAK1
9response to gamma radiationGO:0103329.3BAK1, BCL2
10extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.2BAK1, BCL2
11response to hydrogen peroxideGO:0425429.2BAK1, BCL2
12intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1BCL2, BAK1
13apoptotic processGO:0069159.1BAK1, BCL2
14intrinsic apoptotic signaling pathwayGO:0971939.0BAK1, BCL2
15response to drugGO:0424938.8BAK1, BCL2

Molecular functions related to Benign Mammary Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:0428039.1BAK1, BCL2
2protein heterodimerization activityGO:0469829.0BAK1, BCL2
3identical protein bindingGO:0428028.8BAK1, BCL2

Products for genes affiliated with Benign Mammary Dysplasia

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Sources for Benign Mammary Dysplasia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet